@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3644: (2016-02-19 )
MSLIDPRAIIDPSARLAADVQVGPWSIVGAEVEIGEGTVIGPHVVLKGPTKIGKHNRIYQFSSVGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRAETTIGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVDDWAILSGYTLVHQYCRIGAHSFSGMGSAIGKDVPAYVTVFGNPAEARSMNFEGMRRRGFSSEAIHALRRAYKVVYRQGHTVEEALAELAESAAQFPEVAVFRDSIQSATRGITR
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70......-..80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220......-.230-.......240---........250......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLIDPRAIIDPSA
R
L
A
A
D
V
QVG
P
W
S
I
V
G
A
E
V
EIGE
G
T
V
IGP
H
V
V
L
KGPTKIGKHN
R
I
Y
Q
FSSVGEDTPDLKYKGEP-
T
R
L
V
IGD
H
N
V
I
R
EG
V
T
I
HRGTVQDRAETTIGDH
N
L
I
M
A
Y
A
HIGHDSVIGN
H
C
I
L
VNNT
A
L
A
G
H
V
H
VDD
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
IGAHSFSG
M
G
S
A
IGKDV
P
A
Y
V
T
V
FGNP
A
E
ARSM
N
F
E
G
M
R
RRGF
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
YRQGH
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
QFP
E
----
V
A
V
F
R
D
S
I
Q
S
A
TRGITR
26
PsiBlast_CBE
98.53
100%
-127
- C3 -
5DEP
2
?
E:
[2-258]
-
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
21
PsiBlast_CBE
97.97
100%
-124
- C3 -
5DG3
2
?
E:
[3-258]
--
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
27
PsiBlast_CBE
97.65
100%
-127
- C3 -
5DEP
4
?
D:
[1-258]
M
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
25
PsiBlast_CBE
97.64
100%
-124
- C3 -
5DEP
4
?
F:
[3-258]
--
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
23
PsiBlast_CBE
97.46
100%
-122
- C3 -
5DG3
1
?
C:
[3-258]
--
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
2
PsiBlast_PDB
97.38
100%
-124
- C3 -
5DEP
2
?
A:
[1-258]
M
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
1
PsiBlast_PDB
97.30
100%
-126
- C3 -
5DEM
-
?
A:
[2-258]
-
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
28
PsiBlast_CBE
97.12
100%
-123
- C3 -
5DEP
4
?
B:
[2-258]
-
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
29
PsiBlast_CBE
97.10
100%
-125
- C3 -
5DEM
1
?
B:
[2-258]
-
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
3
PsiBlast_PDB
97.10
100%
-127
- C3 -
5DG3
1
?
A:
[3-258]
--
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
24
PsiBlast_CBE
96.60
100%
-121
- C3 -
5DG3
2
?
B:
[2-258]
-
S
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
D
L
K
Y
K
G
E
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
22
PsiBlast_CBE
96.32
100%
-131
- C3 -
5DG3
1
?
D:
[3-258]
--
L
I
D
P
R
A
I
I
D
P
S
A
R
L
A
A
D
V
Q
V
G
P
W
S
I
V
G
A
E
V
E
I
G
E
G
T
V
I
G
P
H
V
V
L
K
G
P
T
K
I
G
K
H
N
R
I
Y
Q
F
S
S
V
G
E
D
T
P
-------
P
-
T
R
L
V
I
G
D
H
N
V
I
R
E
G
V
T
I
H
R
G
T
V
Q
D
R
A
E
T
T
I
G
D
H
N
L
I
M
A
Y
A
H
I
G
H
D
S
V
I
G
N
H
C
I
L
V
N
N
T
A
L
A
G
H
V
H
V
D
D
W
A
I
L
S
G
Y
T
L
V
H
Q
Y
C
R
I
G
A
H
S
F
S
G
M
G
S
A
I
G
K
D
V
P
A
Y
V
T
V
F
G
N
P
A
E
A
R
S
M
N
F
E
G
M
R
R
R
G
F
S
S
E
A
I
H
A
L
R
R
A
Y
K
V
V
Y
R
Q
G
H
T
V
E
E
A
-
L
A
E
L
-
A
E
S
A
A
Q
F
P
E
----
V
A
V
F
R
D
S
I
Q
S
A
T
R
G
I
T
R
9
PsiBlast_PDB
82.70
54%
-115
- C3 -
4J09
7
LPXA_ECOLI
A:
[6-262]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
4
PsiBlast_PDB
82.43
54%
-116
- C3 -
2AQ9
26
LPXA_ECOLI
A:
[6-262]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
72
HHSearch
81.66
54%
-114
* C3 *
2QIA
1
LPXA_ECOLI
A:
[5-262]
S
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
8
PsiBlast_PDB
81.65
54%
-114
- C3 -
2QIV
1
LPXA_ECOLI
X:
[6-262]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
7
PsiBlast_PDB
81.63
54%
-114
- C3 -
2QIA
1
LPXA_ECOLI
A:
[6-262]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
10
PsiBlast_PDB
81.53
54%
-114
- C3 -
2JF2
2
LPXA_ECOLI
A:
[8-264]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
5
PsiBlast_PDB
81.38
54%
-115
- C3 -
2JF3
1
LPXA_ECOLI
A:
[6-262]
-
A
F
V
H
P
T
A
I
V
E
E
G
A
S
I
G
A
N
A
H
I
G
P
F
C
I
V
G
P
H
V
E
I
G
E
G
T
V
L
K
S
H
V
V
V
N
G
H
T
K
I
G
R
D
N
E
I
Y
Q
F
A
S
I
G
E
V
N
Q
D
L
K
Y
A
G
E
P
-
T
R
V
E
I
G
D
R
N
R
I
R
E
S
V
T
I
H
R
G
T
V
Q
G
G
G
L
T
K
V
G
S
D
N
L
L
M
I
N
A
H
I
A
H
D
C
T
V
G
N
R
C
I
L
A
N
N
A
T
L
A
G
H
V
S
V
D
D
F
A
I
I
G
G
M
T
A
V
H
Q
F
C
I
I
G
A
H
V
M
V
G
G
C
S
G
V
A
Q
D
V
P
P
Y
V
I
A
Q
G
N
H
A
T
P
F
G
V
N
I
E
G
L
K
R
R
G
F
S
R
E
A
I
T
A
I
R
N
A
Y
K
L
I
Y
R
S
G
K
T
L
D
E
V
-
K
P
E
I
-
A
E
L
A
E
T
Y
P
E
----
V
K
A
F
T
D
F
F
A
R
S
T
R
G
L
I
R
13
PsiBlast_PDB
80.17
52%
-117
- C3 -
4EQY
-
LPXA_BURTA
A:
[23-283]
-
S
R
I
H
P
T
A
I
I
E
P
G
A
Q
L
H
E
T
V
E
V
G
P
Y
A
I
V
G
S
N
V
T
I
G
A
R
T
T
I
G
S
H
S
V
I
E
G
H
T
T
I
G
E
D
N
R
I
G
H
Y
A
S
V
G
G
R
P
Q
D
M
K
Y
K
D
E
P
-
T
R
L
V
I
G
D
R
N
T
I
R
E
F
T
T
I
H
T
G
T
V
Q
D
A
G
V
T
T
L
G
D
D
N
W
I
M
A
Y
V
H
I
G
H
D
C
R
V
G
S
H
V
V
L
S
S
N
A
Q
M
A
G
H
V
E
I
G
D
W
A
I
V
G
G
M
S
G
V
H
Q
Y
V
R
I
G
A
H
S
M
L
G
G
A
S
A
L
V
Q
D
I
P
P
F
V
I
A
A
G
N
K
A
E
P
H
G
I
N
V
E
G
L
R
R
R
G
F
S
P
D
A
I
S
A
L
R
S
A
Y
R
I
L
Y
K
N
S
L
S
L
E
E
A
-
K
V
Q
L
-
S
E
L
A
Q
A
G
G
D
G
D
A
A
V
K
A
L
V
D
F
V
E
S
S
Q
R
G
I
I
R
30
PsiBlast_CBE
79.32
50%
-110
- C3 -
4E6T
2
?
C:
[38-294]
--
L
I
H
S
T
A
I
I
D
P
S
A
V
I
A
S
D
V
Q
I
G
P
Y
C
I
I
G
P
Q
V
T
I
G
A
G
T
K
L
H
S
H
V
V
V
G
G
F
T
R
I
G
Q
N
N
E
I
F
Q
F
A
S
V
G
E
V
C
Q
D
L
K
Y
K
G
E
E
-
T
W
L
E
I
G
N
N
N
L
I
R
E
H
C
S
L
H
R
G
T
V
Q
D
N
A
L
T
K
I
G
S
H
N
L
L
M
V
N
T
H
I
A
H
D
C
I
V
G
D
H
N
I
F
A
N
N
V
G
V
A
G
H
V
H
I
G
D
H
V
I
V
G
G
N
S
G
I
H
Q
F
C
K
I
D
S
Y
S
M
I
G
G
A
S
L
I
L
K
D
V
P
A
Y
V
M
A
S
G
N
P
A
H
A
F
G
I
N
I
E
G
M
R
R
K
G
W
S
K
N
T
I
Q
G
L
R
E
A
Y
K
L
I
F
K
S
G
L
T
S
V
Q
A
-
I
D
Q
I
K
S
E
I
L
P
S
V
P
E
----
A
Q
L
L
I
D
S
L
E
Q
S
E
R
G
I
V
R
31
PsiBlast_CBE
79.24
50%
-110
- C3 -
4E6T
1
?
B:
[38-294]
--
L
I
H
S
T
A
I
I
D
P
S
A
V
I
A
S
D
V
Q
I
G
P
Y
C
I
I
G
P
Q
V
T
I
G
A
G
T
K
L
H
S
H
V
V
V
G
G
F
T
R
I
G
Q
N
N
E
I
F
Q
F
A
S
V
G
E
V
C
Q
D
L
K
Y
K
G
E
E
-
T
W
L
E
I
G
N
N
N
L
I
R
E
H
C
S
L
H
R
G
T
V
Q
D
N
A
L
T
K
I
G
S
H
N
L
L
M
V
N
T
H
I
A
H
D
C
I
V
G
D
H
N
I
F
A
N
N
V
G
V
A
G
H
V
H
I
G
D
H
V
I
V
G
G
N
S
G
I
H
Q
F
C
K
I
D
S
Y
S
M
I
G
G
A
S
L
I
L
K
D
V
P
A
Y
V
M
A
S
G
N
P
A
H
A
F
G
I
N
I
E
G
M
R
R
K
G
W
S
K
N
T
I
Q
G
L
R
E
A
Y
K
L
I
F
K
S
G
L
T
S
V
Q
A
-
I
D
Q
I
K
S
E
I
L
P
S
V
P
E
----
A
Q
L
L
I
D
S
L
E
Q
S
E
R
G
I
V
R
11
PsiBlast_PDB
79.10
50%
-112
- C3 -
4E6U
11
?
A:
[9-265]
--
L
I
H
S
T
A
I
I
D
P
S
A
V
I
A
S
D
V
Q
I
G
P
Y
C
I
I
G
P
Q
V
T
I
G
A
G
T
K
L
H
S
H
V
V
V
G
G
F
T
R
I
G
Q
N
N
E
I
F
Q
F
A
S
V
G
E
V
C
Q
D
L
K
Y
K
G
E
E
-
T
W
L
E
I
G
N
N
N
L
I
R
E
H
C
S
L
H
R
G
T
V
Q
D
N
A
L
T
K
I
G
S
H
N
L
L
M
V
N
T
H
I
A
H
D
C
I
V
G
D
H
N
I
F
A
N
N
V
G
V
A
G
H
V
H
I
G
D
H
V
I
V
G
G
N
S
G
I
H
Q
F
C
K
I
D
S
Y
S
M
I
G
G
A
S
L
I
L
K
D
V
P
A
Y
V
M
A
S
G
N
P
A
H
A
F
G
I
N
I
E
G
M
R
R
K
G
W
S
K
N
T
I
Q
G
L
R
E
A
Y
K
L
I
F
K
S
G
L
T
S
V
Q
A
-
I
D
Q
I
K
S
E
I
L
P
S
V
P
E
----
A
Q
L
L
I
D
S
L
E
Q
S
E
R
G
I
V
R
36
PsiBlast_CBE
76.17
41%
-113
- C3 -
3I3A
2
?
B:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
33
PsiBlast_CBE
75.73
41%
-110
- C3 -
3I3X
1
?
C:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
15
PsiBlast_PDB
75.57
41%
-111
- C3 -
3I3A
2
?
A:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
16
PsiBlast_PDB
75.56
41%
-109
- C3 -
3I3X
1
?
A:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
34
PsiBlast_CBE
75.37
41%
-109
- C3 -
3I3X
1
?
B:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
35
PsiBlast_CBE
74.70
41%
-110
- C3 -
3I3A
1
?
C:
[3-257]
---
I
H
P
T
A
I
I
D
P
K
A
E
L
H
E
S
V
E
V
G
P
Y
S
I
I
E
G
N
V
S
I
Q
E
G
T
I
I
E
G
H
V
K
I
C
A
G
S
E
I
G
K
F
N
R
F
H
Q
G
A
V
I
G
V
M
P
Q
D
L
G
F
N
Q
Q
L
L
T
K
T
V
I
G
D
H
N
I
F
R
E
Y
S
N
I
H
K
G
T
K
E
D
-
S
P
T
V
I
G
N
K
N
Y
F
M
G
N
S
H
V
G
H
D
C
I
L
G
N
N
N
I
L
T
H
G
A
V
L
A
G
H
V
T
L
G
N
F
A
F
I
S
G
L
V
A
V
H
Q
F
C
F
V
G
D
Y
S
M
V
A
G
L
A
K
V
V
Q
D
V
P
P
Y
S
T
V
D
G
N
P
S
T
V
V
G
L
N
S
V
G
M
K
R
A
G
F
S
P
E
V
R
N
A
I
K
H
A
Y
K
V
I
Y
H
S
G
I
S
T
R
K
A
-
L
D
E
L
-
E
A
S
G
N
L
I
E
Q
----
V
K
Y
I
I
K
F
F
R
D
S
D
R
G
V
T
N
18
PsiBlast_PDB
74.33
36%
-107
- C3 -
4R37
5
?
A:
[21-275]
--
M
I
S
P
L
A
Y
I
H
P
E
A
K
I
G
E
N
V
E
I
A
P
F
V
Y
I
D
R
N
V
V
I
G
D
N
N
K
I
M
A
N
A
N
I
L
Y
G
S
R
I
G
N
G
N
T
I
F
P
G
A
V
I
G
A
I
P
Q
D
L
K
F
K
G
E
E
-
S
T
A
E
I
G
D
N
N
L
I
R
E
N
V
T
I
N
R
G
T
A
A
-
K
G
R
T
I
V
G
N
N
N
L
L
M
E
G
V
H
V
A
H
D
A
L
I
G
N
G
C
I
V
G
N
S
T
K
M
A
G
E
I
I
I
D
D
N
A
I
I
S
A
N
V
L
M
H
Q
F
C
R
V
G
G
Y
V
M
I
Q
G
G
C
R
F
S
K
D
I
P
P
Y
I
I
A
G
R
E
P
I
A
Y
S
G
I
N
I
I
G
L
R
R
R
G
F
S
N
E
I
I
E
N
I
H
N
A
Y
R
I
I
Y
Q
S
G
L
N
T
S
D
A
-
L
T
K
V
-
E
A
E
V
P
A
S
P
E
----
I
E
Y
I
V
D
F
I
R
N
S
E
R
G
I
I
R
20
PsiBlast_PDB
73.79
39%
-110
- C3 -
1J2Z
4
LPXA_HELPY
A:
[2-255]
-
S
K
I
A
K
T
A
I
I
S
P
K
A
E
I
N
K
G
V
E
I
G
E
F
C
V
I
G
D
G
V
K
L
D
E
G
V
K
L
H
N
N
V
T
L
Q
G
H
T
F
V
G
K
N
T
E
I
F
P
F
A
V
L
G
T
Q
P
Q
D
L
K
Y
K
G
E
Y
-
S
E
L
I
I
G
E
D
N
L
I
R
E
F
C
M
I
N
P
G
T
E
G
G
I
K
K
T
L
I
G
D
K
N
L
L
M
A
Y
V
H
V
A
H
D
C
V
I
G
S
H
C
I
L
A
N
G
V
T
L
A
G
H
I
E
I
G
D
Y
V
N
I
G
G
L
T
A
I
H
Q
F
V
R
I
A
K
G
C
M
I
A
G
K
S
A
L
G
K
D
V
P
P
Y
C
T
V
E
G
N
R
A
F
I
R
G
L
N
R
H
R
M
R
Q
L
-
L
E
S
K
D
I
D
F
I
Y
A
L
Y
K
R
L
F
R
P
I
P
S
L
R
E
S
-
A
K
L
E
-
L
E
E
H
A
N
N
P
F
----
V
K
E
I
C
S
F
I
L
E
S
S
R
G
V
--
73
HHSearch
71.88
40%
-104
- C3 -
1J2Z
4
LPXA_HELPY
A:
[2-257]
-
S
K
I
A
K
T
A
I
I
S
P
K
A
E
I
N
K
G
V
E
I
G
E
F
C
V
I
G
D
G
V
K
L
D
E
G
V
K
L
H
N
N
V
T
L
Q
G
H
T
F
V
G
K
N
T
E
I
F
P
F
A
V
L
G
T
Q
P
Q
D
L
K
Y
K
G
E
Y
-
S
E
L
I
I
G
E
D
N
L
I
R
E
F
C
M
I
N
P
G
T
E
G
G
I
K
K
T
L
I
G
D
K
N
L
L
M
A
Y
V
H
V
A
H
D
C
V
I
G
S
H
C
I
L
A
N
G
V
T
L
A
G
H
I
E
I
G
D
Y
V
N
I
G
G
L
T
A
I
H
Q
F
V
R
I
A
K
G
C
M
I
A
G
K
S
A
L
G
K
D
V
P
P
Y
C
T
V
E
G
N
R
A
F
I
R
G
L
N
R
H
R
M
R
Q
-
L
L
E
S
K
D
I
D
F
I
Y
A
L
Y
K
R
L
F
R
P
I
P
S
L
R
E
S
A
K
L
E
L
-
E
E
-
H
A
N
N
P
F
----
V
K
E
I
C
S
F
I
L
E
S
S
R
G
V
A
Y