@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4277: (2016-02-25 )
MAKEKFERNKPHVNVGTIGHVDHGKTTLTAALTKVCSDTWGGSARAFDQIDNAPEEKARGITINTSHVEYDSAVRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADMVDDAELLELVEMEVRDLLNTYDFPGDDTPIIIGSALMALEGKDDNGIGVSAVQKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRVERGIIKVQEEVEIVGIKATTKTTCTGVEMFRKLLDEGRAGENVGILLRGTKREDVERGQVLAKPGTIKPHTKFECEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIKMVVTLIAPIAMEDGLRFAIREGGRTVGAGVVAKIIE
Atome Classification :
(56 SA)
.........10........20........30.--------------...-..--..40-------.-......-.-.50-------.........60........70........80........90........100.......110..-------.....120.......130.......140---.---.-......150.......160....--...170......--.180--------.----...-------....190.------....--..200...---....210.......220.......230.......240.......250..-.----.....260---........270.......280.......290...---...----.300----....---...310.......320.......330.......340-------------....-------------...-------------.350....---------------...360.......370..------..------...380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKEKFERNKPHVNV
G
T
I
GHVDHG
K
T
T
L
T
A
A
L
--------------
T
K
V
-
C
S--DTW--------G-GSA
R
A
F
-
D
-QI--------DNA
P
E
E
KAR
G
I
T
I
NTSHV
E
Y
D
S
A
V
R
H
Y
A
HVDCPG
H
A
D
Y
V
K
N
M
I
TGAAQMD
G
A
I
L
V
CSAADGPMP-------Q
T
R
E
H
I
L
L
SRQVGV
P
Y
I
V
V
F
LNKADMV----
D
---
D
-
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
N
TYDFPGD--DT
P
I
I
I
G
S
A
L
M
A
--LEG---------K----DDN-------GI
G
V
S
A
V
Q
------
K
L
V
E
--
T
L
D
S
YIP
E
---
P
V
R
A
IDQPFLM
P
I
E
D
V
FSISGR
G
T
V
V
TGRVER
G
I
I
K
V
Q
E
E
V
E
I
V
G
I
-
K
A-T----TKTTC
T
G
----
V
E
M
F
R
K
L
L
DEGRAGE
N
V
G
I
L
L
RGT
K
R
E
D
VERG
Q
V
---LAK----PGTI----KPHT---
K
F
E
C
E
V
Y
V
L
SKEEGGRHTPFFKGYR
P
Q
F
Y
F
R
TTDV--------------TGNC-------------ELP-------------EG
V
E
M
V
MP---------------GDN
I
K
M
V
V
T
L
I
A
P
I
A
M
ED------GL------
R
F
A
I
R
EGGRTV
G
A
G
V
V
A
K
IIE
1
PsiBlast_PDB
96.20
87%
-114
- C2 -
4IW3
3
EFTU1_PSEPK
B:
[46-433]
---------
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
R
V
-
C
S
--
E
V
F
--------
G
-
S
--------
K
I
--------
D
S
A
P
E
E
K
A
R
G
I
T
I
N
T
A
H
V
E
Y
N
S
T
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
----------
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
S
T
Y
D
F
P
G
D
--
D
T
P
I
I
I
G
S
A
R
M
A
--
L
E
G
---------
K
----
D
D
N
-------
E
M
G
T
T
A
V
K
------
K
L
V
E
--
T
L
D
S
Y
I
P
E
---
P
V
R
A
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
-
T
----
T
T
T
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
G
T
K
R
D
D
V
E
R
G
Q
V
---
L
V
K
----
P
G
S
V
----
K
P
H
T
---
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
N
C
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
I
I
E
28
PsiBlast_CBE
96.16
84%
-118
- C2 -
4PC3
2
EFTU1_ECOLI
B:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
------------------------
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
27
PsiBlast_CBE
95.50
84%
-119
- C2 -
4PC6
2
?
B:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
------------------------
K
A
R
G
I
----
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
16
PsiBlast_PDB
95.42
84%
-105
- C2 -
1D8T
22
EFTU1_ECOLI
A:
[3-392]
---
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
25
PsiBlast_CBE
94.94
84%
-107
- C2 -
3U6K
3
?
B:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
5
PsiBlast_PDB
94.91
84%
-110
- C2 -
1DG1
2
EFTU2_ECOLI
G:
[10-393]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
29
PsiBlast_CBE
94.88
84%
-118
- C2 -
4PC2
3
?
B:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
--------------------
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
24
PsiBlast_CBE
94.87
87%
-119
- C2 -
4IW3
4
EFTU1_PSEPK
K:
[46-433]
---------
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
R
V
-
C
S
--
E
V
F
--------
G
----------
K
I
--------
D
S
A
P
E
E
K
A
-
G
I
T
I
N
T
A
H
V
E
Y
N
S
T
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
----------
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
S
T
Y
D
F
P
G
D
--
D
T
P
I
I
I
G
S
A
R
M
A
--
L
E
G
---------
K
----
D
D
N
-------
E
M
G
T
T
A
V
K
------
K
L
V
E
--
T
L
D
S
Y
I
P
E
---
P
V
R
A
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
-
T
----
T
T
T
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
G
T
K
R
D
D
V
E
R
G
Q
V
---
L
V
K
----
P
G
S
V
----
K
P
H
T
---
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
N
C
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
I
I
E
23
PsiBlast_CBE
94.77
87%
-114
- C2 -
4J0Q
4
EFTU1_PSEPK
B:
[45-433]
--------
S
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
R
V
-
C
S
--
E
V
F
--------
G
-
S
-------------------------
A
R
G
I
T
I
N
T
A
H
V
E
Y
N
S
T
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
----
D
---
D
-
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
S
T
Y
D
F
P
G
D
--
D
T
P
I
I
I
G
S
A
R
M
A
--
L
E
G
---------
K
----
D
D
N
-------
E
M
G
T
T
A
V
K
------
K
L
V
E
--
T
L
D
S
Y
I
P
E
---
P
V
R
A
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
-
T
----
T
T
T
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
G
T
K
R
D
D
V
E
R
G
Q
V
---
L
V
K
----
P
G
S
V
----
K
P
H
T
---
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
N
C
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
I
I
E
9
PsiBlast_PDB
94.50
84%
-106
- C2 -
1EFC
2
EFTU1_ECOLI
A:
[8-392]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
34
PsiBlast_CBE
94.42
84%
-112
- C2 -
1D8T
6
EFTU1_ECOLI
B:
[9-392]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
4
PsiBlast_PDB
94.13
84%
-103
- C2 -
4G5G
5
EFTU1_ECOLI
A:
[4-393]
---
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
26
PsiBlast_CBE
94.02
84%
-108
- C2 -
1DG1
2
EFTU2_ECOLI
H:
[10-393]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
2
PsiBlast_PDB
93.91
84%
-110
- C2 -
3U6K
3
EFTU1_ECOLI
A:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
32
PsiBlast_CBE
93.87
84%
-104
- C2 -
1EFC
2
EFTU1_ECOLI
B:
[8-392]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
30
PsiBlast_CBE
93.83
84%
-124
- C2 -
4PC1
1
?
B:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
---------------------------------
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
21
PsiBlast_CBE
93.50
87%
-117
- C2 -
4J0Q
4
EFTU1_PSEPK
E:
[45-433]
--------
S
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
R
V
-
C
S
--
E
V
F
--------
G
-
S
-----------------------------
T
I
N
T
A
H
V
E
Y
N
S
T
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
----
D
---
D
-
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
S
T
Y
D
F
P
G
D
--
D
T
P
I
I
I
G
S
A
R
M
A
--
L
E
G
---------
K
----
D
D
N
-------
E
M
G
T
T
A
V
K
------
K
L
V
E
--
T
L
D
S
Y
I
P
E
---
P
V
R
A
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
-
T
----
T
T
T
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
G
T
K
R
D
D
V
E
R
G
Q
V
---
L
V
K
----
P
G
S
V
----
K
P
H
T
---
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
N
C
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
I
I
E
19
PsiBlast_PDB
93.47
84%
-123
- C2 -
4Q7J
2
EFTU1_ECOLI
B:
[8-392]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-----------------------------------
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
22
PsiBlast_CBE
93.40
87%
-114
- C2 -
4J0Q
3
EFTU1_PSEPK
D:
[45-433]
--------
S
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
R
V
-
C
S
--
E
V
F
--------
G
-
S
----------------------------
I
T
I
N
T
A
H
V
E
Y
N
S
T
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
----
D
---
D
-
A
E
L
L
E
L
V
E
M
E
V
R
D
L
L
S
T
Y
D
F
P
G
D
--
D
T
P
I
I
I
G
S
A
R
M
A
--
L
E
G
---------
K
----
D
D
N
-------
E
M
G
T
T
A
V
K
------
K
L
V
E
--
T
L
D
S
Y
I
P
E
---
P
V
R
A
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
-
T
----
T
T
T
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
G
T
K
R
D
D
V
E
R
G
Q
V
---
L
V
K
----
P
G
S
V
----
K
P
H
T
---
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
N
C
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
I
I
E
6
PsiBlast_PDB
93.03
84%
-120
- C2 -
4PC6
2
?
A:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
---------------------------------
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
3
PsiBlast_PDB
92.85
84%
-109
- C2 -
3U2Q
3
?
A:
[7-393]
------
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
---
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
17
PsiBlast_PDB
92.81
84%
-104
- C2 -
2FX3
2
EFTU1_ECOLI
A:
[7-392]
-------
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
8
PsiBlast_PDB
91.21
84%
-102
- C2 -
1OB2
4
EFTU2_ECOLI
A:
[1-392]
-
A
K
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
A
A
R
A
F
-
D
-
Q
I
--------
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
7
PsiBlast_PDB
88.86
84%
-113
- C2 -
4PC7
3
EFTU1_ECOLI
A:
[9-393]
--------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
-
G
-----------------------------
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
63
PsiBlast_CBE
87.71
84%
-120
- C2 -
2HCJ
7
EFTU1_ECOUT
B:
[1-334]
-----------------------------------------------------------------------------------------------
G
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
E
---
P
E
R
A
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
G
R
G
T
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
-
T
----
Q
K
S
T
C
T
G
----
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
G
I
K
R
E
E
I
E
R
G
Q
V
---
L
A
K
----
P
G
T
I
----
K
P
H
T
---
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
T
I
-------------
E
L
P
-------------
E
G
V
E
M
V
M
P
---------------
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
A
K
V
L
-
41
PsiBlast_CBE
87.55
71%
-99
- C2 -
1EXM
2
EFTU1_THETH
A:
[3-405]
---
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
F
V
T
A
A
--
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
36
PsiBlast_CBE
87.28
71%
-101
* C2 *
4H9G
12
EFTU1_THETH
A:
[2-405]
--
K
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
55
PsiBlast_CBE
87.25
71%
-100
- C2 -
4LBW
11
EFTU1_THETH
A:
[2-404]
---
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
110
HHSearch
87.03
73%
-108
- C2 -
2C78
3
EFTU1_THET8
A:
[9-405]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
--
A
E
N
--------
P
N
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
M
H
R
NPKTRR
G
----
E
N
E
-------
W
V
--
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
-
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
56
PsiBlast_CBE
86.86
71%
-100
- C2 -
4LBV
12
EFTU1_THETH
A:
[2-404]
---
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
42
PsiBlast_CBE
86.84
71%
-105
- C2 -
1TUI
2
EFTU_THEAQ
C:
[9-405]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
E
---------
M
----
H
K
N
PKTKRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
R
L
P
-------------
Q
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
53
PsiBlast_CBE
86.68
71%
-98
- C2 -
4LBZ
10
EFTU1_THETH
A:
[2-404]
---
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
54
PsiBlast_CBE
86.61
71%
-100
- C2 -
4LBY
9
EFTU1_THETH
A:
[4-404]
-----
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
52
PsiBlast_CBE
86.54
71%
-100
- C2 -
4LC0
10
EFTU1_THETH
A:
[2-404]
---
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
44
PsiBlast_CBE
86.39
71%
-107
- C2 -
1TUI
2
EFTU_THEAQ
A:
[9-405]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
E
---------
M
----
H
K
N
PKTKRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
R
L
P
-------------
Q
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
38
PsiBlast_CBE
86.22
71%
-99
- C2 -
1EFT
2
EFTU_THEAQ
A:
[1-405]
-
A
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
F
V
T
A
A
--
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
E
---------
M
----
H
K
N
PKTKRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
R
L
P
-------------
Q
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
37
PsiBlast_CBE
86.14
71%
-105
- C2 -
2C78
3
EFTU1_THET8
A:
[9-405]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A
-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
43
PsiBlast_CBE
86.13
71%
-104
- C2 -
1TUI
2
EFTU_THEAQ
B:
[9-405]
---------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
E
---------
M
----
H
K
N
PKTKRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
R
L
P
-------------
Q
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
51
PsiBlast_CBE
86.11
71%
-100
- C2 -
1B23
5
EFTU_THEAQ
P:
[1-405]
-
A
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
-
A
A
A-
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
E
---------
M
----
H
K
N
PKTKRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
R
L
P
-------------
Q
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
35
PsiBlast_CBE
85.57
71%
-100
- C2 -
2C77
4
EFTU2_THET8
A:
[2-405]
--
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
--------------
T
Y
V
T
A
A
--
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
Y
E
T
A
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
----
D
---
D
-
P
E
L
L
D
L
V
E
M
E
V
R
D
L
L
N
Q
Y
E
F
P
G
D
--
E
V
P
V
I
R
G
S
A
L
L
A
--
L
E
Q
---------
M
----
H
R
N
PKTRRGE
N
E
W
V
D
K
I
W
------
E
L
L
D
--
A
I
D
E
Y
I
P
T
---
P
V
R
D
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
G
R
G
T
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
-
A
P
E
T
----
R
K
T
V
V
T
G
----
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
G
V
S
R
E
E
V
E
R
G
Q
V
---
L
A
K
----
P
G
S
I
----
T
P
H
T
---
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
--------------
T
G
V
V
-------------
Q
L
P
-------------
P
G
V
E
M
V
M
P
---------------
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
------
G
L
------
R
F
A
I
R
E
G
G
R
T
V
G
A
G
V
V
T
K
I
L
E
70
PsiBlast_CBE
69.07
34%
-97
- C2 -
3WY9
1
EF1A_PYRHO
A:
[5-424]
---------
K
P
H
V
N
I
V
F
I
G
H
V
D
H
G
K
S
T
T
I
G
R
L
--------------
L
Y
D
-
T
G
--
N
I
P
--------
E
-
T
I
I
K
K
F
-
E
---SFK
F
A
W
V
M
D
R
L
K
E
E
R
E
R
G
I
T
I
D
V
A
H
T
K
F
E
T
P
H
R
Y
I
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
V
L
V
V
A
A
T
D
G
V
M
P
-------
Q
T
K
E
H
A
F
L
A
R
T
L
G
I
K
H
I
I
V
T
I
N
K
M
D
M
V
----
N
Y--
D
-
Q
K
V
F
E
K
V
K
A
Q
V
E
K
L
L
K
T
L
G
Y
--
K
--
D
F
P
V
I
P
T
S
A
W
N
G
DN
V
V
K
---------
K
----
S
D
K
-------
M
P
W
Y
N
G
-
P
------
T
L
I
E
--
A
L
D
Q
-
I
P
E
---
P
E
K
P
I
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
K
G
V
G
T
V
P
V
G
R
V
E
T
G
K
L
K
V
G
D
V
V
I
F
E
P
A
-
S
T
-
I
----
F
H
K
P
I
Q
G
E
V
K
S
I
E
M
H
H
E
P
L
Q
E
A
L
P
G
D
N
I
G
F
N
V
R
G
V
S
K
N
D
I
K
R
G
D
V
---
A
G
H
TDKP
P
T
V
V
----
R
T
K
D
---
T
F
K
A
Q
I
I
V
L
N
H
P
-----
T
A
I
T
V
G
Y
S
P
V
L
H
A
H
T
A
Q
I
P
V
R
FEQIL
A
K
V
D
PR
T
G
N
I
--------------
V
E
-------------
E
N
P
Q
F
I
K
T
---------------
G
D
S
A
I
V
V
L
R
P
M
K
P
V
V
L
E
P
------
V
K
EIPQLG
R
F
A
I
R
D
M
G
M
T
I
A
A
G
M
V
I
S
I
--
113
HHSearch
68.76
38%
-91
- C2 -
3WY9
1
EF1A_PYRHO
A:
[5-425]
---------
K
P
H
V
N
I
V
F
I
G
H
V
D
H
G
K
S
T
T
I
G
R
L
--------------
L
Y
D
-
T
G
--
N
I
P
E
T
I
I
K
K
F
E----
S
F
K
F
A
W
-
V
M
--------
D
R
L
K
E
E
R
E
R
G
I
T
I
D
V
A
H
T
K
F
E
T
P
H
R
Y
I
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
V
L
V
V
A
A
T
D
G
V
M
P
-------
Q
T
K
E
H
A
F
L
A
R
T
L
G
I
K
H
I
I
V
T
I
N
K
M
D
M
V
----
N
---
Y
D
Q
K
V
F
E
K
V
K
A
Q
V
E
K
L
L
K
T
L
G
Y
--
K
--
D
F
P
V
I
P
T
S
A
W
N
G
--
D
N
V
---------
V
KKSD
K
M
P
-------
W
Y
N
G
P
---------
T
L
I
E
--
A
L
D
Q
-
I
P
E
---
P
E
K
P
I
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
K
G
V
G
T
V
P
V
G
R
V
E
T
G
K
L
K
V
G
D
V
V
I
F
E
P
A
-
S
T
-
I
F
HKP
I
Q
G
E
V
K
S
----
I
E
M
H
H
E
P
L
Q
E
A
L
P
G
D
N
I
G
F
N
V
R
G
V
S
K
N
D
I
K
R
G
D
V
---
A
G
H
----
T
D
K
P
P
T
V
V
R
T
K
D
---
T
F
K
A
Q
I
I
V
L
N
H
P
-----
T
A
I
T
V
G
Y
S
P
V
L
H
A
H
T
A
Q
I
--------------
P
V
R
F
-------------
E
Q
I
L
A
K
V
D
PRTGNIVE
E
N
P
Q
F
I
K
T
---------------
G
D
S
A
I
V
V
L
R
P
M
K
P
V
V
L
E
P
VKEIPQ
L
G
------
R
F
A
I
R
D
M
G
M
T
I
A
A
G
M
V
I
S
I
Q
-
81
PsiBlast_CBE
68.56
31%
-104
- C2 -
1JNY
1
EF1A_SULSO
A:
[4-427]
---------
K
P
H
L
N
L
I
V
I
G
H
V
D
H
G
K
S
T
L
V
G
R
L
L
M
D
RGFID
E
K
T
V
K
E
A
E
E
-
A
A
--
K
K
L
--------
G
-
K
E
S
E
K
F
-
A
F
L
L
--------
D
R
L
K
E
E
-----------
M
R
F
E
T
K
K
Y
F
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
K
K
G
E
Y
E
A
G
M
SVEG
Q
T
R
E
H
I
I
L
A
K
T
M
G
L
D
Q
L
I
V
A
V
N
K
M
D
L
T
EPPY
D
---
E
-
K
R
Y
K
E
I
V
D
-
Q
V
S
K
F
M
R
S
Y
G
F
N
T
N
--
K
V
R
F
V
---
P
V
V
A
--
P
S
G
---------------
D
N
-------
I
T
H
K
S
E
N
M
------
K
W
Y
N
GP
T
L
E
E
Y
L
D
Q
LEL
P
P
K
P
V
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
S
G
V
G
T
V
P
V
G
R
V
E
S
G
V
L
K
V
G
D
--
K
I
V
F
M
-
P
A
-
G
----
K
V
G
E
V
R
S
----
I
E
T
H
H
T
K
M
D
K
A
E
P
G
D
N
I
G
F
N
V
R
G
V
E
K
K
D
I
K
R
G
D
V
---
V
G
H
----
P
N
N
------
P
P
T
VAD
E
F
T
A
R
I
I
V
V
-----
W
H
P
T
A
L
A
N
G
Y
T
P
V
L
H
V
H
T
A
S
V
--------------
A
--
C
-------------
R
V
S
-------------
E
L
V
S
K
L
D
P
RTGQEAEKNPQFLKQ
G
D
V
A
I
V
K
F
K
P
I
K
P
L
C
V
E
K
------
Y
N
EFPPLG
R
F
A
M
R
D
M
G
K
T
V
G
V
G
I
I
V
D
V
--
79
PsiBlast_CBE
68.30
31%
-101
- C2 -
1SKQ
2
EF1A_SULSO
A:
[4-427]
---------
K
P
H
L
N
L
I
V
I
G
H
V
D
H
G
K
S
T
L
V
G
R
L
L
M
D
RGFID
E
K
T
V
K
E
A
E
E
-
A
A
--
K
K
L
--------
G
-
K
E
S
E
K
F
-
A
F
L
L
--------
D
R
L
K
E
E
-----------
M
R
F
E
T
K
K
Y
F
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
K
K
G
E
Y
E
A
G
M
SVEG
Q
T
R
E
H
I
I
L
A
K
T
M
G
L
D
Q
L
I
V
A
V
N
K
M
D
L
T
EPPY
D
---
E
-
K
R
Y
K
E
I
V
D
-
Q
V
S
K
F
M
R
S
Y
G
F
N
T
N
--
K
V
R
F
V
---
P
V
V
A
--
P
S
G
---------------
D
N
-------
I
T
H
K
S
E
N
M
------
K
W
Y
N
GP
T
L
E
E
Y
L
D
Q
L
E
L
P
P
K
P
V
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
S
G
V
G
T
V
P
V
G
R
V
E
S
G
V
L
K
V
G
D
--
K
I
V
F
M
-
P
A
-
G
----
K
V
G
E
V
R
S
----
I
E
T
H
H
T
K
M
D
K
A
E
P
G
D
N
I
G
F
N
V
R
G
V
E
K
K
D
I
K
R
G
D
V
---
V
G
H
----
P
N
N
------
P
P
T
VAD
E
F
T
A
R
I
I
V
V
-----
W
H
P
T
A
L
A
N
G
Y
T
P
V
L
H
V
H
T
A
S
V
--------------
A
--
C
-------------
R
V
S
-------------
E
L
V
S
K
L
D
P
RTGQEAEKNPQFLKQ
G
D
V
A
I
V
K
F
K
P
I
K
P
L
C
V
E
K
------
Y
N
EFPPLG
R
F
A
M
R
D
M
G
K
T
V
G
V
G
I
I
V
D
V
--
78
PsiBlast_CBE
67.12
31%
-99
- C2 -
1SKQ
1
EF1A_SULSO
B:
[4-427]
---------
K
P
H
L
N
L
I
V
I
G
H
V
D
H
G
K
S
T
L
V
G
R
L
LMDRGFIDEKTVKE
A
E
E
-
A
A
--
K
K
L
--------
G
-
K
E
S
E
K
F
-
A
F
L
L
--------
D
R
L
K
E
E
-----------
M
R
F
E
T
K
K
Y
F
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
K
K
G
E
Y
E
AGMSVEG
Q
T
R
E
H
I
I
L
A
K
T
M
G
L
D
Q
L
I
V
A
V
N
K
M
D
L
T
EPPY
D
---
E
-
K
R
Y
K
E
I
V
D
-
Q
V
S
K
F
M
R
S
Y
G
F
N
T
N
--
K
V
R
F
V
---
P
V
V
A
--
P
S
G
---------------
D
N
-------
I
T
H
K
S
E
N
M
------
K
W
Y
N
GP
T
L
E
E
Y
L
D
Q
LEL
P
P
K
P
V
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
S
G
V
G
T
V
P
V
G
R
V
E
S
G
V
L
K
V
G
D
--
K
I
V
F
M
-
P
A
-
G
----
K
V
G
E
V
R
S
----
I
E
T
H
H
T
K
M
D
K
A
E
P
G
D
N
I
G
F
N
V
R
G
V
E
K
K
D
I
K
R
G
D
V
---
V
G
H
----
P
N
N
------
P
P
T
VAD
E
F
T
A
R
I
I
V
V
-----
W
H
P
T
A
L
A
N
G
Y
T
P
V
L
H
V
H
T
A
S
V
--------------
A
--
C
-------------
R
V
S
-------------
E
L
V
S
K
L
D
P
RTGQEAEKNPQFLKQ
G
D
V
A
I
V
K
F
K
P
I
K
P
L
C
V
E
K
------
Y
N
EFPPLG
R
F
A
M
R
D
M
G
K
T
V
G
V
G
I
I
V
D
V
--
80
PsiBlast_CBE
66.31
31%
-100
- C2 -
1JNY
1
EF1A_SULSO
B:
[4-427]
---------
K
P
H
L
N
L
I
V
I
G
H
V
D
H
G
K
S
T
L
V
G
R
L
L
M
D
RGFIDE
K
T
V
K
E
A
E
E
-
A
A
--
K
K
L
--------
G
-
K
E
S
E
K
F
-
A
F
L
L
--------
D
R
---------------
M
R
F
E
T
K
K
Y
F
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
K
K
G
E
Y
E
A
G
M
SVEG
Q
T
R
E
H
I
I
L
A
K
T
M
G
L
D
Q
L
I
V
A
V
N
K
M
D
L
T
EPPY
D
---
E
-
K
R
Y
K
E
I
V
D
-
Q
V
S
K
F
M
R
S
Y
G
F
N
T
N
--
K
V
R
F
V
---
P
V
V
A
--
P
S
G
---------------
D
N
-------
I
T
H
K
S
E
N
M
------
K
W
Y
N
GP
T
L
E
E
Y
L
D
Q
LEL
P
P
K
P
V
D
K
P
L
R
I
P
I
Q
D
V
Y
S
I
S
G
V
G
T
V
P
V
G
R
V
E
S
G
V
L
K
V
G
D
--
K
I
V
F
M
-
P
A
-
G
----
K
V
G
E
V
R
S
----
I
E
T
H
H
T
K
M
D
K
A
E
P
G
D
N
I
G
F
N
V
R
G
V
E
K
K
D
I
K
R
G
D
V
---
V
G
H
----
P
N
N
------
P
P
T
V
A
D
E
F
T
A
R
I
I
V
V
-----
W
H
P
T
A
L
A
N
G
Y
T
P
V
L
H
V
H
T
A
S
V
--------------
A
--
C
-------------
R
V
S
-------------
E
L
V
S
K
L
D
P
RTGQEAEKNPQFLKQ
G
D
V
A
I
V
K
F
K
P
I
K
P
L
C
V
E
K
------
Y
N
EFPPLG
R
F
A
M
R
D
M
G
K
T
V
G
V
G
I
I
V
D
V
--
73
PsiBlast_CBE
65.24
31%
-78
- C2 -
3VMF
3
EF1A_AERPE
A:
[7-430]
---------
K
P
H
M
N
L
V
V
I
G
H
V
D
H
G
K
S
T
L
V
G
H
L
L
Y
R
L
GYIE
E
K
K
L
K
E
L
E
E
-
Q
A
--
K
S
R
--------
G
-
K
E
S
F
K
F
-
A
-
W
I
L-------
D
K
M
K
E
E
R
E
R
G
I
T
I
D
L
T
F
M
K
F
E
T
K
K
Y
V
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
R
K
G
E
F
E
A
G
M
STEG
Q
T
R
E
H
L
L
L
A
R
T
M
G
I
E
Q
I
I
V
A
V
N
K
M
D
A
P
----
D
VNY
D
-
Q
K
R
Y
E
F
V
V
S
V
L
K
K
F
M
K
G
L
G
Y
Q
V
D
--
K
I
P
F
I
P
V
S
A
W
----------------
K
----
G
D
N
-------
L
I
E
R
S
P
N
M
PWYNGP
T
L
V
E
--
A
L
D
Q
L
Q
P
----
P
A
K
P
V
D
K
P
L
R
I
P
V
Q
N
V
Y
S
I
P
G
A
G
T
V
P
V
G
R
V
E
T
G
V
L
R
V
G
D
K
V
--
V
F
M
-
P
P
-
G
----
V
V
G
E
V
R
S
----
I
E
M
H
Y
Q
Q
L
Q
Q
A
E
P
G
D
N
I
G
F
A
V
R
G
V
S
K
S
D
I
K
R
G
D
V
A
G
H
L
D
K
----
P
P
T
V
----
A
--
E
---
E
F
E
A
R
I
F
V
I
W
H
P
S
A
-----
I
T
V
G
Y
T
P
V
I
H
V
H
T
A
S
V
--------------
S
S
R
I
IEIKAKLDPKTGQ
V
V
E
-------------
Q
N
P
Q
F
L
K
A
---------------
G
D
A
A
I
V
R
F
K
P
V
K
P
L
V
V
E
K
------
F
S
EIPQLG
R
F
A
M
R
D
M
N
R
T
V
G
I
G
I
V
T
D
V
--
18
PsiBlast_PDB
61.20
84%
-122
- C2 -
1ETU
2
EFTU1_ECOLI
A:
[5-200]
-----
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
--------------
T
T
V
-
L
A
--
K
T
Y
--------
G
------------------------------
I
T
I
N
T
S
H
V
E
Y
D
T
P
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
-------
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
----
D
---
D
-
E
E
L
L
E
L
V
E
M
E
V
R
E
L
L
S
Q
Y
D
F
P
G
D
--
D
T
P
I
V
R
G
S
A
L
K
A
--
L
E
G
---------
D
----
A
E
----------
W
E
A
K
I
L
------
E
L
A
G
--
F
L
D
S
Y
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
41.72
32%
-73
- C2 -
4ZCM
3
?
B:
[41-302]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
QL
D
F
P
I
V
Y
A
S
A
L
N
G
--
I
A
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
41.50
32%
-72
- C2 -
4ZCL
2
?
B:
[41-302]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
QL
D
F
P
I
V
Y
A
S
A
L
N
G
--
I
A
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
41.20
32%
-73
- C2 -
4ZCM
3
?
A:
[41-302]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
QL
D
F
P
I
V
Y
A
S
A
L
N
G
--
I
A
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
41.19
32%
-69
- C2 -
4ZCL
2
?
A:
[41-302]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
--
I
A
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
38.00
32%
-80
- C2 -
5A9W
1
?
A:
[7-265]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
T
----------------------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
---
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
QL
D
F
P
I
V
Y
A
S
A
L
N
-----
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
36.67
32%
-70
- C2 -
5A9X
1
?
A:
[7-272]
-------------
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
--------------
L
Q
--
Q
S
--
G
-------------------------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
----
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
-------
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
-
I
N
K
V
D
R
---------
P
-
G
A
R
P
D
W
V
V
D
Q
V
F
D
L
F
V
N
L
D
A
T
D
E
QL
D
F
P
I
V
Y
A
S
A
L
N
-----
G
---------
L
----
D
H
E
-------
D
M
A
-
E
D
M
T
------
P
L
Y
Q
--
A
I
V
D
H
V
P
A
---
P
D
V
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
-
E
G
-
K
----
T
R
N
A
K
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
25.04
35%
-48
- C2 -
3J25
1
TET1_ENTFL
A:
[3-130]
------------
I
N
I
G
V
L
A
H
V
D
A
G
K
T
T
L
T
E
S
L
--------------
L
Y
N
-
S
G
A
I
T
E
L
--------
G
-
S
V
D
K
G
T
-
T
-
R
T
--------
D
N
T
L
L
E
R
Q
R
G
I
T
I
Q
T
G
I
T
S
F
Q
W
E
N
T
K
V
N
I
I
D
T
P
G
H
M
D
F
L
A
E
V
Y
R
S
L
S
V
L
D
G
A
I
L
L
I
S
A
K
D
G
V
Q
A
-------
Q
T
R
I
L
F
H
A
L
R
K
M
G
I
P
-
T
I
F
F
I
N
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
3.39
48%
160
- C2 -
2P8W
1
S:
[1-35]
------------------------------------------------
T
-
A
A
--
E
N
P
--------
N
-
V
E
V
K
D
Y
-
G
-
D
I
--------
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------