@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4920: (2016-03-02 )
MQQIQRDIAQALQVQPPFQSEADVQAQIARRIAFIQQCLKDSGLKTLVLGISGGVDSLTAGLLAQRAVEQLREQTGDQAYRFIAVRLPYQVQQDEADAQASLATIRADEEQTVNIGPSVKALAEQLEALEGLEPAKSDFVIGNIKARIRMVAQYAIAGARGGLVIGTDHAAEAVMGFFTKFGDGACDLAPLSGLAKHQVRALARALGAPENLVEKIPTADLEDLRPGHPDEASHGVTYAEIDAFLHGQPLREEAARVIVDTYHKTQHKRELPKAP
Atome Classification :
(36 SA)
.........10........20........30........40.-.-...----...50........60........70........80........90--........100..-...--..110.......120---.......130---.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250----------------........260.......270...----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
Q
I
Q
R
D
I
A
Q
A
LQVQPPFQSE
A
D
V
Q
A
Q
I
A
R
R
I
A
F
I
Q
Q
C
L
K
DS-G-
L
K
T
----
L
V
L
GISG
G
V
D
S
L
T
A
G
L
L
A
Q
R
A
V
E
Q
L
R
E
QTGDQ
A
Y
R
F
I
A
V
RL
P
Y
Q
V--QQDEADAQA
S
L
A
T
-
I
RA--DEE
Q
T
VNIGP
S
V
K
A
L
---
A
E
Q
L
E
A
LEGL---EPAKS
D
F
V
I
G
N
I
K
A
R
I
R
M
V
A
Q
Y
A
IAGARG
G
L
V
I
GT
D
H
A
A
E
A
V
M
G
F
F
T
KFGDGACDLA
P
L
S
G
L
A
K
H
Q
V
R
A
L
A
R
A
LGA
P
E
N
L
V
E
KIPTA
D
L
E
DLRPGHPDEASHG
V
T
Y
A
E
I
D
A
F
LHGQ
P
L
R
-----------------
E
E
A
A
R
V
I
V
D
T
Y
H
K
T
Q
H
K
RELPKAP----------
1
PsiBlast_PDB
98.88
100%
-108
- C6 -
4XFD
-
NADE_PSEAE
A:
[9-283]
M
Q
Q
I
Q
R
D
I
A
Q
A
L
Q
V
Q
P
P
F
Q
S
E
A
D
V
Q
A
Q
I
A
R
R
I
A
F
I
Q
Q
C
L
K
D
S
-
G
-
L
K
T
----
L
V
L
G
I
S
G
G
V
D
S
L
T
A
G
L
L
A
Q
R
A
V
E
Q
L
R
E
Q
T
G
D
Q
A
Y
R
F
I
A
V
R
L
P
Y
Q
V
--
Q
Q
D
E
A
D
A
Q
A
S
L
A
T
-
I
R
A
--
D
E
E
Q
T
V
N
I
G
P
S
V
K
A
L
---
A
E
Q
L
E
A
L
E
G
L
---
E
P
A
K
S
D
F
V
I
G
N
I
K
A
R
I
R
M
V
A
Q
Y
A
I
A
G
A
R
G
G
L
V
I
G
T
D
H
A
A
E
A
V
M
G
F
F
T
K
F
G
D
G
A
C
D
L
A
P
L
S
G
L
A
K
H
Q
V
R
A
L
A
R
A
L
G
A
P
E
N
L
V
E
K
------------------
H
G
V
T
Y
A
E
I
D
A
F
L
H
G
Q
P
L
R
-----------------
E
E
A
A
R
V
I
V
D
T
Y
H
K
T
Q
H
K
R
E
L
P
K
A
P
----------
32
PsiBlast_CBE
83.70
51%
-92
- C6 -
4Q16
2
NADE_DEIRA
B:
[8-274]
L
S
P
L
R
S
H
I
I
R
E
L
H
V
Q
P
----
D
I
D
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
T
-
P
-
T
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
A
D
E
A
D
A
Q
Q
A
L
D
F
-
I
Q
A
--
D
R
E
V
T
V
N
I
K
E
A
A
D
A
S
---
V
A
A
A
Q
A
A
L
G
S
---
E
--
V
R
D
F
V
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
R
K
-------
D
D
R
P
G
L
P
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
-----------------
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
----------
13
PsiBlast_PDB
83.37
51%
-87
- C6 -
4Q16
2
NADE_DEIRA
A:
[8-274]
L
S
P
L
R
S
H
I
I
R
E
L
H
V
Q
P
----
D
I
D
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
T
-
P
-
T
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
A
D
E
A
D
A
Q
Q
A
L
D
F
-
I
Q
A
--
D
R
E
V
T
V
N
I
K
E
A
A
D
A
S
---
V
A
A
A
Q
A
A
L
G
S
---
E
--
V
R
D
F
V
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
R
K
V
P
T
A
D
L
----
P
G
L
P
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
-----------------
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
----------
30
PsiBlast_CBE
82.73
51%
-87
- C6 -
4Q16
2
NADE_DEIRA
D:
[8-274]
L
S
P
L
R
S
H
I
I
R
E
L
H
V
Q
P
----
D
I
D
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
T
-
P
-
T
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
A
D
E
A
D
A
Q
Q
A
L
D
F
-
I
Q
A
--
D
R
E
V
T
V
N
I
K
E
A
A
D
A
S
---
V
A
A
A
Q
A
A
L
G
S
---
E
--
V
R
D
F
V
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
R
K
V
P
T
A
D
----
R
P
G
L
P
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
-----------------
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
----------
46
HHSearch
82.20
49%
-94
- C6 -
1WXI
4
NADE_ECOLI
A:
[2-268]
--
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
A
D
E
Q
D
C
Q
D
A
I
A
F
I
Q
-
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
S
---
E
Q
A
L
R
E
A
------
G
I
E
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
K
A
-------------
D
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
-----------------
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
----------
3
PsiBlast_PDB
82.14
55%
-92
- C6 -
3Q4G
3
NADE_VIBCH
A:
[19-272]
----------------------
D
P
Q
F
E
I
E
R
R
V
A
F
I
K
R
K
L
T
E
A
-
R
-
Y
K
S
----
L
V
L
G
I
S
G
G
V
D
S
T
T
C
G
R
L
A
Q
L
A
V
E
E
L
N
Q
Q
H
N
T
T
E
Y
Q
F
I
A
V
R
L
P
Y
G
E
--
Q
K
D
E
D
E
A
Q
L
A
L
S
F
-
I
R
P
--
T
H
S
V
S
V
N
I
K
A
G
V
D
G
L
H
A
A
S
H
H
A
L
A
N
T
G
L
IPS
D
P
A
K
V
D
F
I
K
G
N
V
K
A
R
A
R
M
V
A
Q
Y
E
I
A
G
Y
V
G
G
L
V
L
G
T
D
H
S
A
E
N
I
T
G
F
Y
T
K
F
G
D
G
A
C
D
L
A
P
L
F
G
L
N
K
R
Q
V
R
L
L
A
K
T
L
G
A
P
E
Q
L
V
Y
K
T
P
T
A
D
-------------
L
N
L
T
Y
E
Q
I
D
D
F
L
E
G
K
A
V
P
-----------------
A
E
V
S
Q
R
L
V
A
I
Y
H
A
T
Q
H
K
R
Q
---------------
2
PsiBlast_PDB
81.70
55%
-99
- C6 -
3DPI
1
NADE_BURP1
A:
[18-274]
-----------
L
H
V
S
P
T
F
----
D
A
R
D
E
A
E
R
R
I
G
F
V
A
D
Y
L
R
T
A
-
G
-
L
R
A
----
C
V
L
G
I
S
G
G
I
D
S
S
T
A
G
R
L
A
Q
L
A
V
E
R
L
R
A
S
G
Y
D
A
--
R
F
V
A
M
R
L
P
Y
G
A
-----
E
A
D
A
R
R
A
L
A
F
-
V
R
A
--
D
E
T
L
T
V
D
V
K
P
A
A
D
A
M
---
L
A
A
L
A
A
G
G
L
A
YL-
D
H
A
Q
Q
D
F
V
L
G
N
I
K
A
R
E
R
M
I
A
Q
Y
A
V
A
G
A
R
N
G
V
V
I
G
T
D
H
A
A
E
S
V
M
G
F
F
T
K
F
G
D
G
G
A
D
V
L
P
L
A
G
L
T
K
R
R
V
R
A
L
A
R
M
L
G
A
D
E
P
L
V
L
K
T
P
T
A
D
L
E
T
L
R
P
Q
R
P
--
H
A
Y
G
I
T
Y
E
Q
I
D
D
F
L
E
G
K
P
M
D
-----------------
D
A
V
A
E
T
V
L
R
F
Y
D
A
T
R
H
K
R
A
L
P
-------------
6
PsiBlast_PDB
81.55
52%
-86
- C6 -
3HMQ
8
NADE_SALTY
A:
[3-265]
---
L
Q
Q
E
I
I
Q
A
L
G
A
K
P
H
I
N
P
E
E
E
I
R
----
R
S
V
D
F
L
K
A
Y
L
K
T
Y
-
P
F
L
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
S
Q
M
A
I
A
E
L
R
E
E
T
G
D
N
A
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
A
D
E
Q
D
C
Q
D
A
I
A
F
-
I
Q
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
----
S
E
Q
A
L
R
E
A
G
I
---
E
--
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
H
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
H
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
G
C
P
E
H
L
Y
K
K
-------------
P
D
E
A
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
T
L
D
-----------------
P
A
I
A
K
T
I
E
G
W
Y
V
K
T
E
H
K
R
R
L
P
-------------
4
PsiBlast_PDB
81.47
51%
-83
- C6 -
2PZ8
3
NADE_BACAN
A:
[3-263]
---
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
K
D
E
D
D
A
Q
L
A
L
Q
F
-
I
Q
A
--
D
Q
S
V
A
F
D
I
A
S
T
V
D
A
F
---
S
N
Q
Y
E
N
L
--
L
---
D
E
S
L
T
D
F
N
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
-----------------
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
-------------
68
Fugue
81.23
49%
-79
* C6 *
2NSY
8
NADE_BACSU
A:
[1-271]
--
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
-----
D
Q
L
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
FDDWWK----
10
PsiBlast_PDB
81.17
48%
-85
- C6 -
1FYD
3
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
27
PsiBlast_CBE
81.16
48%
-99
- C6 -
1IH8
1
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
------
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
--------------------
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
22
PsiBlast_CBE
81.04
51%
-82
- C6 -
2PZA
5
NADE_BACAN
B:
[3-263]
---
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
K
D
E
D
D
A
Q
L
A
L
Q
F
-
I
Q
A
--
D
Q
S
V
A
F
D
I
A
S
T
V
D
A
F
---
S
N
Q
Y
E
N
L
--
L
---
D
E
S
L
T
D
F
N
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
-----------------
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
-------------
17
PsiBlast_PDB
81.02
49%
-93
- C6 -
1WXH
1
NADE_ECOLI
A:
[3-265]
---
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
N
A
E
E
E
I
R
----
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
-
P
F
I
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
-----
E
Q
D
C
Q
D
A
I
A
F
-
I
Q
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
----
S
E
Q
A
L
R
E
A
G
I
---
E
--
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
-----------------
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
-------------
29
PsiBlast_CBE
81.00
48%
-99
- C6 -
1EE1
2
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
------
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
5
PsiBlast_PDB
80.96
51%
-82
- C6 -
2PZA
5
NADE_BACAN
A:
[3-263]
---
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
K
D
E
D
D
A
Q
L
A
L
Q
F
-
I
Q
A
--
D
Q
S
V
A
F
D
I
A
S
T
V
D
A
F
---
S
N
Q
Y
E
N
L
--
L
---
D
E
S
L
T
D
F
N
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
-----------------
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
-------------
31
PsiBlast_CBE
80.92
51%
-96
- C6 -
4Q16
2
NADE_DEIRA
C:
[11-274]
---
L
R
S
H
I
I
R
E
L
H
V
Q
P
----
D
I
D
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
T
-
P
-
T
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
A
D
E
A
D
A
Q
Q
A
L
D
F
-
I
Q
A
--
D
R
E
V
T
V
N
I
K
E
A
A
D
A
S
---
V
A
A
A
Q
A
A
L
G
S
---
E
--
V
R
D
F
V
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
----------------
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
-----------------
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
----------
28
PsiBlast_CBE
80.79
48%
-102
- C6 -
1IFX
2
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
-------
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
23
PsiBlast_CBE
80.79
51%
-85
- C6 -
2PZ8
3
NADE_BACAN
B:
[3-263]
---
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
K
D
E
D
D
A
Q
L
A
L
Q
F
-
I
Q
A
--
D
Q
S
V
A
F
D
I
A
S
T
V
D
A
F
---
S
N
Q
Y
E
N
L
--
L
---
D
E
S
L
T
D
F
N
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
-----------------
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
-------------
15
PsiBlast_PDB
80.76
49%
-91
- C6 -
1WXF
-
NADE_ECOLI
A:
[3-265]
---
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
N
A
E
E
E
I
R
----
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
-
P
F
I
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
-----
E
Q
D
C
Q
D
A
I
A
F
-
I
Q
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
----
S
E
Q
A
L
R
E
A
G
I
---
E
--
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
-----------------
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
-------------
24
PsiBlast_CBE
80.41
48%
-80
- C6 -
2NSY
8
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
18
PsiBlast_PDB
80.32
49%
-87
- C6 -
1WXI
4
NADE_ECOLI
A:
[3-265]
---
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
N
A
E
E
E
I
R
----
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
-
P
F
I
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
A
D
E
Q
D
C
Q
D
A
I
A
F
-
I
Q
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
----
S
E
Q
A
L
R
E
A
G
I
---
E
--
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
K
A
-------------
D
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
-----------------
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
-------------
8
PsiBlast_PDB
79.87
48%
-80
- C6 -
2NSY
8
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
14
PsiBlast_PDB
79.85
49%
-91
- C6 -
1WXE
3
NADE_ECOLI
A:
[3-265]
---
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
N
A
E
E
E
I
R
----
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
-
P
F
I
K
S
----
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
A
D
E
Q
D
C
Q
D
A
I
A
F
-
I
Q
P
--
D
R
V
L
T
V
N
I
K
G
A
V
L
A
----
S
E
Q
A
L
R
E
A
G
I
---
E
--
L
S
D
F
V
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
-----------------
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
-------------
25
PsiBlast_CBE
79.78
48%
-80
- C6 -
1NSY
5
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
26
PsiBlast_CBE
79.76
48%
-79
- C6 -
1KQP
14
NADE_BACSU
B:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
11
PsiBlast_PDB
79.72
48%
-102
- C6 -
1IFX
2
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
-------
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
9
PsiBlast_PDB
79.68
48%
-77
- C6 -
1EE1
4
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
12
PsiBlast_PDB
79.30
48%
-79
- C6 -
1IH8
3
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
7
PsiBlast_PDB
78.46
48%
-78
- C6 -
1NSY
5
NADE_BACSU
A:
[2-262]
---
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
-
G
-
A
K
G
----
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
-
I
K
P
--
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
---
S
D
Q
Y
Q
Q
E
T
G
D
---
Q
L
--
T
D
F
N
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
-----------------
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
-------------
47
HHSearch
69.50
35%
-72
- C6 -
3FIU
5
?
A:
[6-247]
--------------------
D
F
S
P
K
E
Y
S
Q
K
L
V
N
W
L
S
D
S
C
M
N
Y
-
P
-
A
E
G
----
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
T
-
G
----------
L
P
T
T
A
L
I
L
P
S
D
N
NQ
H
Q
D
M
Q
D
A
L
E
L
I
E
M
-
L
-
N
--
I
E
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
---
L
A
S
T
Q
S
F
T
---------
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
---
Q
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
-----------------
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
----------
69
Fugue
67.26
31%
-70
- C6 -
1XNG
4
NADE_HELPY
B:
[3-264]
---------------------
K
D
Y
Q
K
L
I
V
Y
L
C
D
F
L
E
K
E
V
Q
K
R
-
G
-
F
K
K
----
V
V
Y
G
L
S
G
G
L
D
S
A
V
V
G
V
L
C
Q
K
V
F
K
E
N
----------
A
H
A
L
L
M
P
S
S
V
--
S
M
P
E
N
K
T
D
A
L
N
L
C
-
E
K
--------
F
S
I
P
Y
T
E
Y
S
I
---
A
P
Y
D
A
I
F
S
S
H
---
F
K
D
A
S
L
T
R
K
G
N
F
C
A
R
L
R
M
A
F
L
Y
D
Y
S
L
K
S
D
S
L
V
I
G
T
S
N
K
S
E
R
M
L
G
Y
G
T
L
F
G
D
L
A
C
A
I
N
P
I
G
E
L
F
K
T
E
V
Y
E
L
A
R
R
L
N
I
P
K
K
I
L
N
K
P
P
S
A
D
L
---
F
V
G
Q
S
D
E
K
D
L
G
Y
P
Y
S
V
I
D
P
L
L
K
D
I
E
A
L
FQTKPIDTETLAQLGYD
E
I
L
V
K
N
I
T
S
R
I
Q
K
N
A
F
K
L
E
L
P
A
I
A
KRFNPELEHH
33
PsiBlast_CBE
63.85
36%
-58
- C6 -
3FIU
5
?
D:
[18-247]
------------------------------------
N
W
L
S
D
S
-
C
-
M
N
Y
PAEG
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
--------
T
G
L
P
T
---
T
A
L
I
L
P
S
D
N
--
N
Q
H
Q
-
D
M
Q
D
A
L
E
L
-
I
E
M
LN
I
E
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
---
L
A
S
T
Q
S
F
T
---------
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
-----------------
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
----------
35
PsiBlast_CBE
63.64
36%
-55
- C6 -
3FIU
5
?
B:
[18-247]
------------------------------------
N
W
L
S
D
S
-
C
-
M
N
Y
PAEG
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
--------
T
G
L
P
T
---
T
A
L
I
L
P
S
D
N
--
N
Q
H
Q
-
D
M
Q
D
A
L
E
L
-
I
E
M
LN
I
E
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
---
L
A
S
T
Q
S
F
T
---------
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
-----------------
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
----------
34
PsiBlast_CBE
63.47
36%
-57
- C6 -
3FIU
5
?
C:
[18-247]
------------------------------------
N
W
L
S
D
S
-
C
-
M
N
Y
PAEG
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
--------
T
G
L
P
T
---
T
A
L
I
L
P
S
D
N
--
N
Q
H
Q
-
D
M
Q
D
A
L
E
L
-
I
E
M
LN
I
E
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
---
L
A
S
T
Q
S
F
T
---------
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
-----------------
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
----------
19
PsiBlast_PDB
63.21
36%
-57
- C6 -
3FIU
5
?
A:
[18-247]
------------------------------------
N
W
L
S
D
S
-
C
-
M
N
Y
PAE
G
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
--------
T
G
L
P
T
---
T
A
L
I
L
P
S
D
N
--
N
Q
H
Q
-
D
M
Q
D
A
L
E
L
-
I
E
M
L
N
I
E
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
---
L
A
S
T
Q
S
F
T
---------
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
-----------------
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
----------