@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : R5LFF7_9FIRM: (2019-02-01 )
MVSDYVDDESSVRINRKMELIKVPDESAGNAMIGISYLTREDGKIIADRIKELCNESRYNNSFWEEALYIKDKMMVSAKTVSSKDVIEINTYEQLREIDENSDQLDTDAISVICEAFKINKNDIYNITVLKKGMTNRSFLFECKGKKYIMRIPGEGTDMLINRREEAEVYNVVNKEKICDNVIYINPDNGYKITEFIENSRVCDPFNEDDVKRCMDKLRTFHNLKLKVNHEFNILGQMKFYESLWNEKSVYDDYELTKANVLSLKKYVEDNVSEKVLTHIDAVPDNFLFAGDEIRLIDWEYAGMHDPHVDIAXXAGMQDPHVDIAMFAIYSLYDREQTDRLIDAYFTGNCDKKTRLKIYCYIAMCGLLWSNWCEYKRQLGVEFGEYSLRQYRYAKDFYRIFINESEQIKEELK
Atome Classification :
(20 SA)
.........10........20......-..30........40-----........50........60........70........80...-----.....90........100...--....110..--.....120---........130-........140.--.--.----------....150.......160......--...170-.......180...----.-....--190.......-200.--.--.--.----....210.....----..220......----.230-------------.----.----....---------------..240.....-.--------------.------------250--.--------------.......260.....----------------.------.270.......280.......---290------.-.......300.......310--.-.-..-----...320..-----.....330--------.------------------.......340.......----------350------------.----------.----...---....360.......370..---.....--380-.---........390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVSDYVDDESS
V
R
I
N
R
K
M
E
L
I
KVPDES-AG
N
A
M
I
G
I
S
Y
L
TRE-----D
G
K
I
I
A
D
R
I
K
E
L
C
NESRYN
N
S
F
W
E
E
A
L
Y
I
K
D
K
M
M
V
S
A
KTVSSK-----
D
V
I
E
IN
T
Y
E
Q
L
R
E
IDENSDQL--
D
T
D
A
I
S
V
I
C
--
E
A
F
KINK----N
D
I
Y
N
I
T
V
L
K--KGMTNR
S
F
L
F
E
C--K--G----------
K
K
Y
I
M
RIPGEGT
D
M
L
--INRR
E
E
--
A
E
V
Y
N
V
-
V
N
K
E
KICD-
N
V
I
Y
----I-NPDN--GY
K
I
T
E
F
IEN-S-RV--C--D--P----F
N
E
D
D
V
K
R
C
M
D
K
----
L
R
T
F
H
N
L
K
L
K
V
----NHE--------------
F
----
N
----
I
L
G
Q
---------------
M
K
F
Y
E
S
L
WNE-K--------------S------------VY---D--------------DYEL
T
K
A
N
V
L
S
L
K
K
Y
----------------
V
------
E
DN
V
S
E
K
V
L
T
H
I
DAVPDN
F
L
F---AG-------
D
-
E
I
R
L
I
D
W
E
YAGMHDPHV
D
I
A
--
X
-X-AG-----MQDPH
V
D
I
-----
A
M
F
A
I
Y
S
---------
L
------------------
Y
D
R
E
Q
T
D
R
L
I
D
A
YFTGN----------C--------------D----------K----
K
T
R
---
L
K
I
Y
C
Y
I
A
M
C
G
L
L
W
S
N
W
C
E
---
Y
K
R
Q
L--G---V---
E
F
G
E
Y
S
L
R
Q
Y
R
Y
A
K
D
F
Y
R
I
FINE
S
E
Q
I
K
E
ELK
3
PsiBlast_PDB
97.40
31%
0
- C- -
-
4R7B
-
?
A:
[47-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
N
Q
N
Y
L
A
K
T
--
T
--
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
--
K
--
Y
N
L
E
L
L
K
D
L
G
L
D
-
V
K
N
Y
----
L
F
D
I
E
A
--
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
--
L
--
D
--
S
----
T
S
---
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
----
R
G
E
--------------
F
----
A
----
P
F
E
E
---------------
I
K
K
Y
E
S
L
I
E
E
-
Q
--------------
I
------------
P
Y
---
A
--------------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
---
S
P
-------
Q
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
--------------------------
A
L
F
L
E
S
E
---------
F
------------------
T
S
Q
E
E
E
T
F
L
--
S
H
Y
E
S
D
----------
Q
--------------
T
----------
P
----
V
S
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
---
Y
K
E
E
Q
--
G
---
E
---
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
-------------------
2
PsiBlast_PDB
97.40
31%
0
- C- -
-
4R78
2
?
A:
[47-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
N
Q
N
Y
L
A
K
T
--
T
--
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
--
K
--
Y
N
L
E
L
L
K
D
L
G
L
D
-
V
K
N
Y
----
L
F
D
I
E
A
--
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
--
L
--
D
--
S
----
T
S
---
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
----
R
G
E
--------------
F
----
A
----
P
F
E
E
---------------
I
K
K
Y
E
S
L
I
E
E
-
Q
--------------
I
------------
P
Y
---
A
--------------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
---
S
P
-------
Q
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
--------------------------
A
L
F
L
E
S
E
---------
F
------------------
T
S
Q
E
E
E
T
F
L
--
S
H
Y
E
S
D
----------
Q
--------------
T
----------
P
----
V
S
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
---
Y
K
E
E
Q
--
G
---
E
---
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
-------------------
1
PsiBlast_PDB
97.40
31%
0
- C- -
-
4R77
-
?
B:
[27-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
N
Q
N
Y
L
A
K
T
--
T
--
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
--
K
--
Y
N
L
E
L
L
K
D
L
G
L
D
-
V
K
N
Y
----
L
F
D
I
E
A
--
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
--
L
--
D
--
S
----
T
S
---
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
----
R
G
E
--------------
F
----
A
----
P
F
E
E
---------------
I
K
K
Y
E
S
L
I
E
E
-
Q
--------------
I
------------
P
Y
---
A
--------------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
---
S
P
-------
Q
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
--------------------------
A
L
F
L
E
S
E
---------
F
------------------
T
S
Q
E
E
E
T
F
L
--
S
H
Y
E
S
D
----------
Q
--------------
T
----------
P
----
V
S
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
---
Y
K
E
E
Q
--
G
---
E
---
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
-------------------
31
HHSearch
97.07
27%
0
- C- -
-
4R7B
-
?
A:
[23-304]
-----------------------------------------------------------------------------------------------------------------------
K
I
I
K
E
K
I
S
--
S
L
L
S
Q
E
-----
E
E
V
L
S
V
E
Q
L
---
G
G
M
T
N
Q
N
Y
L
A
K
T
--
T
--
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
--
K
Y
N
L
E
L
-
L
K
D
L
G
L
D
V
-
K
N
Y
L
----
F
-
D
I
E
A
--
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
--
L
--
D
S
-
T
----
S
I
K
T
K
F
D
K
I
A
P
I
----
L
Q
T
I
H
T
S
A
K
E
L
----
R
G
E
--------------
F
----
A
----
P
F
E
E
---------------
I
K
K
Y
E
S
L
I
E
E
-
Q
--------------
I
------------
P
Y
---
A
--------------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
---
S
P
Q------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
----------------------
P
M
W
D
L
-----
A
A
L
F
L
E
S
---------
E
------------------
F
T
S
Q
E
E
E
T
F
L
S
H
Y
E
S
D
Q
-------------------------
T
----------
P
----
V
S
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
---
Y
K
E
E
Q
--
G
---
E
---
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
-----------
30
HHSearch
97.07
27%
0
- C- -
-
4R78
2
?
A:
[23-304]
-----------------------------------------------------------------------------------------------------------------------
K
I
I
K
E
K
I
S
--
S
L
L
S
Q
E
-----
E
E
V
L
S
V
E
Q
L
---
G
G
M
T
N
Q
N
Y
L
A
K
T
--
T
--
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
--
K
Y
N
L
E
L
-
L
K
D
L
G
L
D
V
-
K
N
Y
L
----
F
-
D
I
E
A
--
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
--
L
--
D
S
-
T
----
S
I
K
T
K
F
D
K
I
A
P
I
----
L
Q
T
I
H
T
S
A
K
E
L
----
R
G
E
--------------
F
----
A
----
P
F
E
E
---------------
I
K
K
Y
E
S
L
I
E
E
-
Q
--------------
I
------------
P
Y
---
A
--------------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
---
S
P
Q------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
----------------------
P
M
W
D
L
-----
A
A
L
F
L
E
S
---------
E
------------------
F
T
S
Q
E
E
E
T
F
L
S
H
Y
E
S
D
Q
-------------------------
T
----------
P
----
V
S
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
---
Y
K
E
E
Q
--
G
---
E
---
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
-----------
43
HHSearch
88.67
19%
0
- C- -
-
5FUT
10
CHKA_HUMAN
A:
[10-373]
-----------------------------------------------------------------------------------------------------------------------
R
R
A
Y
L
W
C
K
--
E
F
L
P
G
A
W
RGLR
E
D
E
F
H
I
S
V
I
R
--
G
G
L
S
N
M
L
F
Q
C
S
L
--
P
--
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
--
S
V
M
F
A
I
-
L
A
E
R
S
L
G
P
-
K
L
Y
G
----
I
-
F
P
----
Q
G
R
L
E
Q
F
I
P
S
-
R
-
R
L
--
D
--
T
EE
L
----
S
L
P
D
I
S
A
E
I
A
E
K
----
M
A
T
F
H
G
M
K
M
P
F
----
N
K
E
--------------
P
----
K
W---
L
F
G
T
---------------
M
E
K
Y
L
K
E
V
L
R
I
K
F-------------
T
------------
E
E
S
R
I
K
K
L
H
K
L
---------
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
------
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
---
L
E
GRENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
----------------------
R
G
F
D
I
-----
G
N
H
F
C
E
W
---------
M
YDYSYEKYPF
F
R
A
N
IRKY
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
----------
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
----
E
M
L
---
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
---
V
Q
A
K
I
--
S
---
S
IEF
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
---------------
44
HHSearch
88.09
19%
0
- C- -
-
5FTG
11
CHKA_HUMAN
A:
[10-373]
-----------------------------------------------------------------------------------------------------------------------
R
R
A
Y
L
W
C
K
--
E
F
L
P
G
A
W
RGLR
E
D
E
F
H
I
S
V
I
R
--
G
G
L
S
N
M
L
F
Q
C
S
L
--
P
--
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
--
S
V
M
F
A
I
-
L
A
E
R
S
L
G
P
-
K
L
Y
G
----
I
-
F
P
----
Q
G
R
L
E
Q
F
I
P
S
-
R
-
R
L
--
D
--
T
EE
L
----
S
L
P
D
I
S
A
E
I
A
E
K
----
M
A
T
F
H
G
M
K
M
P
F
----
N
K
E
--------------
P
----
K
W---
L
F
G
T
---------------
M
E
K
Y
L
K
E
V
L
R
I
K
F-------------
T
------------
E
E
S
R
I
K
K
L
H
K
L
---------
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
------
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
---
L
E
GRENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
----------------------
R
G
F
D
I
-----
G
N
H
F
C
E
W
---------
M
YDYSYEKYPF
F
R
A
N
IRKY
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
----------
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
----
E
M
L
---
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
---
V
Q
A
K
I
--
S
---
S
IEF
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
---------------
15
Fugue
87.36
20%
1
- C4 -
-
2QG7
-
?
A:
[50-458]
-------------------------------
Y
P
I
T
E
S
N
L
R
I
L
-----
E
G
E
D
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
--------------------------------------------
N
P
----
N
E
V
D
S
L
E
F
Q
I
--
I
N
G
T
N
I
L
I
K
V
K
D
MS
K
--
Q
----------
A
K
Y
L
I
R
L
Y
G
P
-
T
D
E
I
--
I
N
R
E
R
E
--
K
K
I
S
C
I
-
L
Y
N
K
N
I
A
K
-
K
I
Y
V
----
F
-
F
T
N
G
----
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
R
E
D
--
I
----
K
N
P
K
F
Q
K
L
I
A
K
N
----
L
K
L
L
H
D
I
K
L
N
E
----
N
L
Y
--------------
K
----
E
----
L
Q
V
T
QKVPGTRPSF
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
-
R
--------------
K
KICSFDAKA
N
I
L
K
L
---
I
--------------
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
------
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VG
E
G
-------
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
--
N
H
F
-
N
E
-----
Y
A
G
F
N
C
D
W
-----
D
L
T
P
--------------------------------
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
----------
D
--------------
E
----------
E
----
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
---
L
Q
G
M
H
--
S
---
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
---------
P
I
F
R
S
K
V
-
32
HHSearch
84.44
23%
0
- C- -
-
3DXQ
-
?
B:
[21-287]
------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
E
R
L
--
G
G
L
T
N
L
V
F
R
A
------------------
G
D
L
C
L
R
I
P
----------
N
R
A
N
E
--
A
V
A
A
R
E
-
A
A
K
A
G
V
S
P
-
E
V
L
H
----
V
-
D
P
A
T
--
G
V
M
V
T
R
Y
I
A
G
-
A
Q
T
M
--
S
--
P
--
E
K
F
K
-
T
R
P
G
S
P
A
R
A
G
E
A
----
F
R
K
L
H
G
S
G
A
V
F
----
P
F
R
--------------
F
----
E
----
L
F
A
M
---------------
I
D
D
Y
L
K
V
L
S
T
K
N
V
-------------
T
------------
L
P
---
A
--------------
G
Y
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
---
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
----------------------
P
L
W
D
L
-----
G
D
L
S
V
E
G
---------
K
------------------
F
N
A
N
Q
D
E
E
L
M
R
A
Y
F
G
G
E
----------
A
--------------
R
----------
P
----
A
E
R
---
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
---
I
Q
L
A
N
--
D
NPV
D
---
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
T
-------------
33
HHSearch
84.34
23%
0
- C- -
-
3DXQ
-
?
A:
[21-287]
------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
E
R
L
--
G
G
L
T
N
L
V
F
R
A
------------------
G
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
--
A
V
A
A
R
E
-
A
A
K
A
G
V
S
P
-
E
V
L
H
----
V
-
D
P
A
T
--
G
V
M
V
T
R
Y
I
A
G
-
A
Q
T
M
--
S
--
P
--
E
K
F
K
-
T
R
P
G
S
P
A
R
A
G
E
A
----
F
R
K
L
H
G
S
G
A
V
F
----
P
F
R
--------------
F
----
E
----
L
F
A
M
---------------
I
D
D
Y
L
K
V
L
S
--
N
V-------------
T
------------
L
P
---
A
--------------
G
Y
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
---
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
----------------------
P
L
W
D
L
-----
G
D
L
S
V
E
G
---------
K
------------------
F
N
A
N
Q
D
E
E
L
M
R
A
Y
F
G
G
E
----------
A
--------------
R
----------
P
----
A
E
R
---
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
---
I
Q
L
A
N
--
D
NPV
D
---
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
T
-------------
17
Fugue
81.34
12%
-33
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
---------------
G
M
K
E
L
L
S
T
M
D
L
D
---------------------------------
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
P
L
-----
E
H
L
R
I
S
R
I
K
G
G
M
----------------------------
S
----
N
M
L
F
L
C
R
L
S
E
--
V
Y
P
P
I
R
N
-------
E
--
P
----------
N
K
V
L
L
R
V
Y
F
-
N
P
E
T
E
--
S
H
L
V
A
E
--
S
V
I
F
T
L
-
L
S
E
R
H
L
G
P
-
K
L
Y
G
----
I
-
F
S
----
G
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
--
E
--
I
----
S
L
A
H
M
S
T
K
I
A
K
R
----
V
A
K
V
H
Q
L
E
V
P
I
----
W
K
E
P-------------
D
----
Y
----
L
C
E
A
---------------
L
Q
R
W
L
K
Q
L
T
G
-
T
--------------
V
------------
D
A
---
E
H
R
F
D
L
PEECGVSSV
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
---
P
--------
K
-
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
--
N
-
H
-
F
I
E
W
T
ID
Y
D
I
D
E
A
P
F
-----
Y
K
I
Q
T
E
N
---------
F
------------------
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
----------
G
--------------
N
TRENE
L
Y
K
K
S
E
----
D
L
V
---
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
---
L
Q
V
E
L
--
S
---
P
---
V
----
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-
39
HHSearch
78.68
24%
0
- C- -
-
3C5I
3
?
D:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
R
V
K
Q
I
L
----
L
T
N
Q
L
F
E
V
G
L
--
K
--
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
I
Y
G
K
H
V
D
E
L
--
Y
N
T
I
S
E
--
F
E
V
Y
K
T
-
M
S
K
Y
K
I
A
P
-
Q
L
L
N
----
T
-
F
--
N
--
G
G
R
I
E
E
W
L
Y
G
-
D
-
P
L
--
R
--
I
D
D
L
----
K
N
P
T
I
L
I
G
I
A
N
V
----
L
G
K
F
H
T
L
S
R
K
R
----
H
L
P
EH------------
W
DRTP
C
----
I
F
K
M
---------------
M
E
K
W
K
N
Q
L
F
K
Y
K
NIE-----------
K
------------
Y
N
---
C
--------------
D
I
H
K
Y
I
K
E
S
D
K
F
I
K
F
----------------
M
K
V
Y
S
KS
D
N
L
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
---
T
N
-------
K
-
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
----------------------
L
A
T
D
I
-----
A
N
F
F
I
E
T
---------
S
IDYSVSSYPF
F
E
I
D
KKKY
I
S
Y
E
N
R
K
L
F
I
T
A
Y
L
S
N
Y
L
DKVV-----
P
--------------
T
----------
P
K
L
I
D
E
I
L
---
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
---
I
R
G
Y
Q
--
T
---------------------------------------
4
PsiBlast_PDB
76.26
23%
0
- C- -
-
3DXQ
-
?
A:
[28-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
N
L
V
F
------
R
--
A
----------
G
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
--
A
V
A
A
R
E
-
A
A
K
A
G
V
S
P
-
E
V
L
H
----
V
-
D
P
A
T
--
G
V
M
V
T
R
Y
I
A
G
-
A
-
Q
T
--
M
--
S
--
P
E
K
F
K
T
R
P
G
S
P
A
R
A
G
E
A
----
F
R
K
L
H
G
S
G
A
V
F
----
P
F
R
--------------
F
----
E
----
L
F
A
M
---------------
I
D
D
Y
L
K
V
L
S
-----------------
N
------------
V
T
LP-
A
--------------
G
Y
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
---
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
--
D
-------------------------
L
S
V
E
G
---------
K
------------------
F
N
A
N
Q
D
E
E
L
M
R
A
Y
F
G
G
E
----------
A
--------------
R
----------
P
----
A
E
R
---
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
----------------------------------------------------
52
SP3
74.07
11%
-13
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------------------------------------------------------------------------
G
M
K
E
L
L
S
T
---------
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
--
H
M
L
C
A
R
F
L
G
--
G
A
W
K
T
V
P
----
L
E
H
L
R
I
S
R
I
K
--
G
G
M
S
N
M
L
F
L
C
R
L
--
S
--
E
VYPPIRNEP-
N
K
V
L
L
R
V
Y
F
-
N
P
E
T
E
--
S
H
L
V
A
E
--
S
V
I
F
T
L
-
L
S
E
R
H
L
G
P
-
K
L
Y
G
----
I
-
F
S
G
----
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
--
E
--
I
----
S
L
A
H
M
S
T
K
I
A
K
R
----
V
A
K
V
H
Q
L
E
V
P
I
----
W
K
E
--------------
P
----
D
Y
---
L
C
E
A
---------------
L
Q
R
W
L
K
Q
L
T
G
-
T
V
DAE
H
R
F
D
L
PEECG
V
------------
S
S
---
V
--------------
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
---
P
--------
K
-
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
-
I
-
E
W
-----
T
I
D
Y
D
I
D
E
APF
Y
K
I
Q
T
E
N
F
P
---------
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
TRENE
L
Y
K
K
S
E
--------------
D
----------
L
----
V
Q
E
---
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
EL
S
P
V
G
F
--
G
---
F
---
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
--------
37
HHSearch
68.71
21%
0
- C- -
-
2QG7
-
?
E:
[109-448]
---------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
F
Q
I
I
N
--
G
-
I
T
N
I
L
I
K
V
K
D
--
M
SK
Q
----------
A
K
Y
L
I
R
L
Y
G
P
K
T
D
E
I
--
I
N
R
E
R
E
--
K
K
I
S
C
I
-
L
Y
N
K
N
I
A
K
-
K
I
Y
V
----
F
-
F
T
-
N
--
G
-
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
--
R
ED
I
----
K
N
P
K
F
Q
K
L
I
A
K
N
----
L
K
L
L
H
D
I
K
L
N
E
----
N
L
Y
KELQVTQKVPGTRP
S
----
F
----
L
W
N
T
---------------
I
W
K
Y
F
H
L
L
N
E
E
R
K-------------
K
ICSFDAKANIL-
K
L
---
I
--------------
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
------
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
---
T
V
GG-----
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
----------------------
R
A
Y
D
I
-----
A
N
H
F
N
E
Y
AGFNCDWDL
T
------------------
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
----------
D
--------------
E
ELI-------
N
----
Q
L
I
---
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
---
L
Q
G
M
H
--
S
SD-
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
--------------------
40
HHSearch
61.70
17%
0
- C- -
-
3MES
3
?
A:
[73-410]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
K
Q
I
F
--
S
G
L
T
N
Q
L
F
V
V
S
I
--
V
--
N
ELKH------
P
R
I
L
F
R
I
Y
G
K
H
V
-
K
F
--
Y
D
S
K
V
E
--
L
D
V
F
R
Y
-
L
S
N
I
N
I
A
P
-
N
I
I
A
----
D
-
F
P
----
E
G
R
I
E
E
F
I
D
G
-
E
-
P
L
--
T
--
T
--
K
Q
L
--
Q
L
T
H
I
C
V
E
V
A
K
N
----
M
G
S
L
H
I
I
N
S
K
R
----
A
D
F
PSR-----------
F
----
D
KEPI
L
F
K
R
---------------
I
Y
L
W
R
E
E
A
K
I
Q
V
S
K
NN----------
I
------------
D
K
---
E
--------------
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
------
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
---
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
----------------------
A
G
A
D
I
-----
A
N
Y
F
C
E
Y
---------
I
YDYCSEKQPY
F
K
F
K
YEDY
P
C
E
E
L
R
K
L
F
I
S
V
Y
L
S
Q
T
----------
L
--------------
Q
EQVMPS----
Q
Q
I
V
H
I
M
T
---
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
---
A
----V-
E
---
F
---
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
-----------
36
HHSearch
60.13
21%
0
- C- -
-
2QG7
-
?
D:
[109-448]
---------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
F
Q
I
I
N
--
G
G
-
T
N
I
L
I
K
V
K
D
--
M
SK
Q
----------
A
K
Y
L
I
R
L
Y
G
P
K
T
D
-----
N
R
E
R
E
--
K
K
I
S
C
I
-
L
Y
N
K
N
I
A
K
-
K
I
Y
V
----
F
-
F
T
-
N
--
G
-
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
--
R
E
D
I
----
K
N
P
K
F
Q
K
L
I
A
K
N
----
L
K
L
L
H
D
I
K
L
N
E
----
N
L
Y
K
E
L
Q
V
T
Q
K
V
P
G
T
R
P
S
----
F
----
L
W
N
T
---------------
I
W
K
Y
F
H
L
L
N
E
E
R
K
-------------
K
I
C
S
F
D
A
KANIL-
K
L
---
I
--------------
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
------
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
---
T
V
G
------
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
----------------------
R
A
Y
D
I
-----
A
N
H
F
N
E
Y
A
G
F
N
CDWDL
T
------------------
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
----------
D
--------------
E
ELI-------
N
----
Q
L
I
---
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
---
L
Q
G
M
H
--
S
S
D
-
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
--------------------
41
HHSearch
59.89
17%
0
- C- -
-
3MES
2
?
B:
[73-410]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
K
Q
I
F
--
S
G
L
T
N
Q
L
F
V
V
S
I
--
V
--
N
ELKH------
P
R
I
L
F
R
I
Y
G
K
H
V
--
F
--
Y
D
S
K
V
E
--
L
D
V
F
R
Y
-
L
S
N
I
N
I
A
P
-
N
I
I
A
----
D
-
F
P
----
E
G
R
I
E
E
F
I
D
G
-
E
-
P
L
--
T
--
T
--
K
Q
L
--
Q
L
T
H
I
C
V
E
V
A
K
N
----
M
G
S
L
H
I
I
N
S
K
R
----
A
D
F
PSR-----------
F
----
D
KEPI
L
F
K
R
---------------
I
Y
L
W
R
E
E
A
K
I
Q
V
S
K
NNQ---------
I
------------
D
K
---
E
--------------
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
------
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
---
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
----------------------
A
G
A
D
I
-----
A
N
Y
F
C
E
Y
---------
I
YDYCSEKQPY
F
K
F
K
YEDY
P
C
E
E
L
R
K
L
F
I
S
V
Y
L
S
Q
T
----------
L
--------------
Q
EQVMPS----
Q
Q
I
V
H
I
M
T
---
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
---
A
----SV
E
---
F
---
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
-----------
26
Fugue
55.24
16%
28
- C1 -
-
4FDT
1
?
A:
[21-425]
M
Q
T
K
I
Q
K
Y
A
G
T
A
--------
M
P
Y
P
N
R
T
-
D
G
M
T
P
F
Y
I
N
H
L
G
R
H
GARFP
T
S
R
K
A
L
D
K
V
E
K
V
L
V
S
A
Q
Q
E
N
G
L
T
S
E
G
M
A
L
L
S
M
I
R
R
L
S
R
L
F
D
G
Q
WGKLS
K
L
G
E
T
E
Q
E
G
I
A
G
R
M
I
R
N
Y
P
Q
L
FS
N
S
A
K
I
E
A
I
A
T
Y
V
P
R
S
I
N
S
----
M
D
A
F
L
S
C
M
I
R
--
H
N
P
A
L
Q
V
Q
R
S
E
G
--
K
--
Q
----------
Y
N
H
I
L
R
F
F
D
L
N
K
S
Y
V
--
N
Y
K
E
K
G
D
W
L
P
I
Y
K
A
-
F
V
H
K
K
I
S
P
-
V
P
I
M
K
K
F
L
L
-
N
P
E
Q
YL
D
K
E
A
E
E
F
V
M
A
L
F
-
S
V
--
A
--
A
--
I
----
L
P
D
T
S
I
P
L
N
L
E
D
----
L
F
T
------------
L
D
E
--------------
W
----
H
----
R
Y
W
Q
---------------
T
Q
N
L
R
Q
Y
M
S
K
-
S
--------------
S
------------
A
P
---
V
--------------
G
K
M
L
P
V
A
I
A
W
P
L
L
S
E
----------------
F
------
I
R
S
A
Q
E
V
I
S
G
K
S
D
Y
-
Q
A
N
F
R
F
---
A
H
-------
A
-
E
T
V
I
P
F
V
S
L
M
G
I
E
K
T
D
V
Q
V
C
--
R
-
P
-
D
S
-----
V
S
V
Y
W
K
D
Y
-----
E
I
S
P
M
A
A
------------------------------------
N
V
Q
W
L
F
Y
R
D
----------
R
--------------
D
----------
Q
----
R
I
W
---
V
K
I
L
L
N
E
E
A
A
A
L
P
I
S
T
A
C
--------------------
F
P
Y
Y
S
---
W
E
K
T
R
I
F
F
N
Q
R
I
E
M
A
K
K
T
L
S
V
F
N
23
Fugue
54.48
19%
-2
- C3 -
-
4Q05
-
?
A:
[34-360]
--------
E
N
S
W
Q
I
G
P
R
----
T
L
P
A
P
S
G
A
S
D
V
L
Y
N
I
I
S
K
T
P
T
-----
P
V
P
T
I
N
L
N
L
V
------
P
R
T
E
S
E
W
R
A
A
I
T
Q
L
D
E
---------------------
G
K
V
D
M
A
R
E
I
S
K
Q
L
----------
S
V
S
V
--
E
H
G
V
I
E
G
----
V
S
V
Y
Y
V
T
P
V
E
VA
P
D
L
E
D
K
L
F
V
H
T
H
--
G
--
G
-----------------------
A
F
--
V
L
N
G
G
E
--
A
G
T
I
E
A
-
I
V
I
A
T
L
A
K
V
R
V
L
S
----
I
-
D
-----------
Y
R
M
P
-
P
-
S
H
--
P
--
A
--
P
----
A
A
R
D
D
V
F
T
V
Y
Q
H
----
L
L
K
Q
G
S
A
Q
K
I
A
L
G
G
S
S
G
G
--------------
A
----
N
----
L
T
-----------------
M
G
L
V
Q
H
L
I
E
Q
---------------------------------------------------
E
V
D
L
P
G
A
L
F
L
G
T
P
----------------
G
------
A
D
M
S
K
T
G
D
S
Y
Y
I
N
D
G
I
D
R
N
L
V
---
T
------------------
Y
D
G
F
L
E
A
A
V
R
L
Y
--
A
-
N
G
R
D
-----
L
K
D
P
L
V
S
P
-----
L
Y
G
D
L
H
G
---------
F
------------------
P
P
--------
T
F
L
I
T
G
T
----------
R
--------------
D
LL--------
L
----
S
A
T
---
V
R
T
H
I
K
L
R
Q
S
G
V
V
-
A
D
L
F
V
---
Y
E
-----
G
---
I
---
A
H
G
D
Y
A
V
D
L
T
--
A
P
E
T
Q
H
A
F
A
E
L
N
A
F
L
L
Q
H
L
R