@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : F8JLQ4_STREN: (2019-01-28 )
MLAERGRLLLTVVGELLAAEVCAAGTRIRGPDERARRERQRALRIRTALERLGPLYVKAGQVLSTREDLVPPAVARELESLHDRAAPCPFDRMSAVLEAELGPDWRRRFRHFDTERPLGCASIAQAYAAVLDDGRSVVVKVQRPGIAAQMTTDMRLLRGMTRTLARRTPVLSETIDFEAMLAVIFEAVRNELDLTLEAANMDEARAAVTAVPGIDVPGVVHATERVLIQRRAPGTSVRDADPAAFDDAERERVGTGLLTVMYQGYFIDHRFHADPHPGNVFVCPGGPTTLIDWGMIGRLDRHLSSTLLMTLLGLANNDAHAVARAWSEMGRPTPWADIGAFEQDMSVVVPRLASIPLDRLRFGASLATLLRLSTRRGIRTNPMIGLLGKSFANMEGTVRHLAPHLSATDVLVRQTGRVLGEYAAQSLSQQQLGFTALQLLSGLETLLPHARAVGRSLSGGDLTLQHTAVTRPFSLVDHRSSARIRRAEHHLLGAAALVWLLRRRGRG
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50.--------.....----..60.....----------..-.-70....---..-..80........90.------.......100..--------...--------.--.110...-....120--..-......130-.-......140..-.....150.......160---.........170.......180----......----..190.......200.......210...--..-..220-.--...-------....230...----....240..-..-.-----...250-.........260.----------...--...270.......280..-..-...290....--...----------------------300.......310-------------.......--------.------.320..---.-....330-...---------...--..-.------340..---...-------..350--...-------..--..-..360.....-----------..370.......380-----------.....-...390.......400..--.....410--..-...--.--...420.......430.-......440---........-450---...-......460-.-----------------------......470----.........480.......490.......500.....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLAER
G
R
L
L
L
T
V
V
G
E
L
L
A
A
E
V
C
AAGTRIRG
P
D
E
R
A
R
R
E
R
Q
R
A
L
R
I
R
T
A
L
E
RL--------G
P
L
Y
V
----KAGQVLS
T
R
----------ED-L-V
P
P
A
V
A
---
R
E
-
L
E
S
L
H
DRAAPC
P
F
D
R
------
M
S
A
V
L
E
AELG
P
D
--------
W
R
R
--------
R
--
F
R
HFDTE-RPL
G
C
A
---
S
I
-
A
Q
A
Y
A
A
V
LD-D-G
R
S
V
V
V
K
V
QRP-GI
A
A
Q
M
T
T
D
M
R
L
L
R
G
M
-----
T
R
T
L
A
RRTPVLSETI
D
F
E
A
M
L
-----
A
V
I
F
E
A
----
V
R
NEL
D
L
T
L
EAA
N
M
D
E
A
R
A
A
VTAVPGID--VP-
G
V
V
H
--
A
--
T
E
R
-------
V
L
IQRRAPGT----SVRDA-DPA-AF-
D
-----
D
A
E
R
---
E
R
V
G
T
G
L
L
T
V
M
YQ----------
G
Y
F
--
I
D
H
R
FHADPHPG
N
V
F
VCP-GG-
P
T
T
L
I
D
W
G
M
I
--
G
R
L
----------------------
D
R
H
L
S
S
T
L
L
M
T
---------------
L
L
GLANN--------
D
------
A
H
A
V
A
R
---
A
-
W
S
EMG---RPT---------PW
A
--
D
I
-
G
------
A
F
E
Q
D
---
M
S
V
-------
V
V
P
----
R
L
A
-------SI--
P
L
-
D
R
L
R
F
G
A
S
L
A
-----------
T
L
L
R
L
S
TRRGIRTN------------P
M
I
G
L
-
L
G
K
S
FA
N
M
E
G
T
V
R
H
LAPH--
L
S
A
T
D
V
----
L
V
-
R
Q
T
--
G
--
R
V
L
G
E
Y
A
A
Q
S
L
S
Q
Q
Q
L
G
-
F
T
A
L
Q
L
L
S
----
G
L
E
T
L
L
P
H
-
A
-----
R
A
V-GRSLSGG
D
L
-
T
-----------------------
L
Q
H
TAVT------RP
F
S
L
VDHRSS
A
R
I
R
R
A
E
H
H
L
L
G
A
A
A
L
V
W
L
L
R
RRGRG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
82.96
22%
-13
- C5 -
-
4PED
-
COQ8A_HUMAN
A:
[4-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
--------
R
G
A
A
L
----
K
L
G
Q
M
L
S
I
Q
----------
D
D
-
A
F
I
N
P
H
L
A
---
K
I
-
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
------
M
M
K
T
L
N
N
D
L
G
P
N
--------
W
R
D
--------
K
--
L
E
Y
F
E
E
--
R
P
F
A
A
A
---
S
I
-
G
Q
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
K
I
Q
Y
P
-
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
-----
L
N
M
S
N
M
L
-
P
---
E
G
L
F
P
E
H
L
I
-----
D
V
L
R
R
E
----
L
A
L
E
C
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
--
V
P
-
E
I
V
D
--
E
LC
S
P
H
-------
V
L
T
T
E
L
V
S
G
F
----
P
L
D
Q
A
-
E
G
L
----
S
-----
Q
E
I
R
---
N
E
I
C
Y
N
I
L
V
L
C
L
R
----------
E
L
F
--
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
D
P
Q
Q
H
-
K
V
A
L
L
D
F
G
A
T
--
R
E
Y
----------------------
D
R
S
F
T
D
L
Y
I
Q
I
---------------
I
R
A
A
A
D
R
--------
D
------
R
E
T
V
R
A
---
K
-
S
I
E
M
K
---
F
L
T
---------
G
Y
---
E
V
-
K
------
V
M
E
D
A
H
L
D
A
I
L
-------
I
L
G
----
E
A
F
A
S-----
D
E
PF
D
F
-
G
T
Q
S
T
T
E
K
I
H
-----------
N
L
I
P
V
M
L
R
H
R
L
V
P
P
------------
P
E
E
T
Y
S
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
--
F
P
C
K
A
M
----
F
E
-
E
A
Y
--
S
--
N
Y
C
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
75.68
24%
-4
- C5 -
-
5YK0
4
?
A:
[52-445]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
E
L
M
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
E
A
A
I
------
P
D
-
E
-
F
G
E
P
Y
R
---
E
A
-
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
D
--
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
L
S
P
----
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
--
T
-----
T
E
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
R
L
A
R
E
K
--------
N
------
Y
D
L
L
L
P
---
T
-
M
E
K
A
G
---
L
I
Q
---------
R
G
R
QV
S
V
-
R
------
E
I
D
E
M
---
L
R
Q
-------
Y
V
E
----
P
I
Q
VE
V
F
H
Y
T
R
K
--
W
L
-
Q
K
M
T
V
S
Q
I
D
R
-----------
S
V
A
Q
I
R
T
A
R
Q
M
D
L
P
------------
A
K
L
A
I
-
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
--
V
P
I
K
A
L
----
S
E
-
E
L
I
--
P
--
G
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.66
24%
-4
- C5 -
-
5YK1
2
?
A:
[52-445]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
E
L
M
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
E
A
A
I
------
P
D
-
E
-
F
G
E
P
Y
R
---
E
A
-
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
D
--
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
L
S
P
----
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
--
T
-----
T
E
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
R
L
A
R
E
K
--------
N
------
Y
D
L
L
L
P
---
T
-
M
E
K
A
G
---
L
I
Q
---------
R
G
R
QV
S
V
-
R
------
E
I
D
E
M
---
L
R
Q
-------
Y
V
E
----
P
I
Q
VE
V
F
H
Y
T
R
K
--
W
L
-
Q
K
M
T
V
S
Q
I
D
R
-----------
S
V
A
Q
I
R
T
A
R
Q
M
D
L
P
------------
A
K
L
A
I
-
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
--
V
P
I
K
A
L
----
S
E
-
E
L
I
--
P
--
G
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.25
31%
-5
- C5 -
-
5YJZ
2
?
A:
[61-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
----------
E
A
-
A
-
I
P
D
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
-
D
-
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
----
L
S
P
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
T
-
T
-----
E
-
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.23
31%
-4
- C5 -
-
5YK1
2
?
A:
[61-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
----------
E
A
-
A
-
I
P
D
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
-
D
-
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
----
L
S
P
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
T
-
T
-----
E
-
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
68.23
31%
-5
- C5 -
-
5YK0
4
?
A:
[61-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
----------
E
A
-
A
-
I
P
D
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
-
D
-
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
----
L
S
P
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
T
-
T
-----
E
-
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.78
31%
-3
- C5 -
-
5YK2
1
?
A:
[61-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
Q
L
F
T
V
L
G
E
L
--------
K
G
G
A
M
----
K
V
G
Q
A
L
S
V
M
----------
E
A
-
A
-
I
P
D
E
F
G
EP
Y
R
E
A
L
T
K
L
---
A
P
P
L
P
A
S
K
------
V
H
R
V
L
D
G
Q
L
G
T
K
--------
W
R
E
--------
R
--
F
S
S
F
N
-
D
-
T
P
V
A
S
A
---
S
I
-
G
Q
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
K
I
Q
Y
P
-
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
-----
V
G
V
L
K
Q
----
L
S
P
G
A
D
V
Q
G
V
V
-----
D
E
L
V
E
R
----
T
E
M
E
L
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
--
V
P
-
H
V
V
A
--
S
--
A
P
K
-------
V
V
I
Q
E
W
I
E
G
V
----
P
M
A
E
I
-
I
R
H
-
G
T
-
T
-----
E
-
Q
R
---
D
L
I
G
T
L
L
A
E
L
T
F
D
----------
A
P
R
--
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
L
P
-
D
G
-
R
M
G
I
I
D
F
G
A
V
--
A
P
M
----------------------
P
G
G
F
P
I
E
L
G
M
T
---------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.33
26%
7
- C5 -
-
5I35
1
COQ8A_HUMAN
A:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
K
L
G
Q
M
L
S
I
Q
----------
D
D
A
F
-
I
N
P
H
L
A
---
K
I
-
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
------
M
M
K
T
L
N
N
D
L
G
P
N
--------
W
R
D
--------
K
--
L
E
Y
F
E
-
E
-
R
P
F
A
A
A
---
S
I
-
G
Q
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
K
I
Q
Y
P
-
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
-----
L
N
M
----
S
N
M
L
P
E
G
L
F
P
E
H
L
I
-----
D
V
L
R
R
E
----
L
A
L
E
C
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
--
V
P
-
E
I
V
D
EL
C
--
S
P
H
-------
V
L
T
T
E
L
V
S
G
F
----
P
L
D
Q
A
-
E
---
G
L
-
S
-----
Q
E
I
R
---
N
E
I
C
Y
N
I
L
V
L
C
L
R
----------
E
L
F
--
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
D
P
-
Q
Q
H
K
V
A
L
L
D
F
G
A
T
--
R
E
Y
----------------------
D
R
S
F
T
D
L
Y
I
Q
I
---------------
I
R
A
A
A
D
R
--------
D
------
R
E
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.16
26%
14
- C5 -
-
4PED
-
COQ8A_HUMAN
A:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
K
L
G
Q
M
L
S
I
Q
----------
D
D
A
F
-
I
N
P
H
L
A
---
K
I
-
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
------
M
M
K
T
L
N
N
D
L
G
P
N
--------
W
R
D
--------
K
--
L
E
Y
F
E
-
E
-
R
P
F
A
A
A
---
S
I
-
G
Q
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
K
I
Q
Y
P
-
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
-----
L
N
M
----
S
N
M
L
P
E
G
L
F
P
E
H
L
I
-----
D
V
L
R
R
E
----
L
A
L
E
C
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
--
V
P
-
E
I
V
D
EL
C
--
S
P
H
-------
V
L
T
T
E
L
V
S
G
F
----
P
L
D
Q
A
-
E
---
G
L
-
S
-----
Q
E
I
R
---
N
E
I
C
Y
N
I
L
V
L
C
L
R
----------
E
L
F
--
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
D
P
-
Q
Q
H
K
V
A
L
L
D
F
G
A
T
--
R
E
Y
----------------------
D
R
S
F
T
D
L
Y
I
Q
I
---------------
I
R
A
A
A
D
R
--------
D
------
R
E
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
59.04
20%
-20
- C5 -
-
5HC3
-
?
A:
[22-365]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
N
K
I
A
-
E
D
P
R
I
D
------
P
R
I
K
A
I
F
S
G
M
--------
D
---
L
----
G
G
G
G
D
V
E
S
R
----------
E
A
-
M
-
L
E
A
A
S
S
---
E
E
-
A
T
A
V
R
D
G
L
R
----
V
F
------
L
D
A
C
D
N
E
E
I
A
P
S
--------
A
G
L
--------
K
--
I
E
D
Y
E
F
T
S
E
P
D
G
N
I
---
A
K
-
I
Q
Y
I
R
P
D
S
T
-
D
-
K
L
P
C
V
Y
Y
I
H
G
G
-
G
M
Q
-
S
L
S
C
Y
Y
G
N
Y
R
A
W
-----
G
K
I
I
A
S
N
G
V
---------
A
V
A
-----
M
V
E
F
R
N
----
A
L
V
P
S
A
L
P
E
V
A
P
Y
P
A
G
L
N
D
C
V
S
G
V
K
W
V
A
A
H
A
D
-
E
L
G
I
--
D
--
A
S
R
-------
I
I
I
A
G
E
S
G
G
G
----
N
L
T
L
A
-
A
G
L
-
R
L
-
K
-----
Q
E
G
S
---
Q
D
L
I
Q
G
L
Y
A
L
C
-------------------------
P
Y
I
A
G
S
W
P
S
E
-
D
S
-
P
S
S
T
E
N
N
G
I
L
----
L
----------------------
D
L
H
---------------------------
N
N
Q
--------
G
------
A
M
G
Y
G
I
---
E
-
A
Y
E
M
R
---
D
P
L
---------
A
W
P
--
G
F
--------
A
T
E
E
D
---
V
S
G
-------
L
V
P
----
T
F
I
-------
S
V
--
N
E
C
D
P
L
R
D
E
G
--
I
-----------
N
F
Y
R
L
L
L
R
A
G
V
S
A
K
------------
C
R
Q
V
M
----------
G
T
I
H
G
T
E
I
F
--
P
I
A
C
P
D
----
V
S
-
R
D
T
--
A
--
A
S
I
A
N
F
C
K
----------------------------------------------
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
56.94
23%
24
- C2 -
-
3LMM
-
?
B:
[9-574]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
R
R
E
Q
L
I
A
Q
V
E
S
I
L
A
S
A
A
D
G
R
V
Q
K
T
K
E
T
Q
S
V
D
F
K
E
E
A
G
R
R
N
G
P
Q
I
E
P
G
K
P
E
N
P
E
A
A
D
K
L
A
D
E
V
A
C
M
A
N
TPG
G
G
A
L
I
V
GIED
K
T
G
R
I
I
G
T
------------
E
-
L
-
D
I
D
W
L
R
---
Q
G
-
I
F
T
R
I
D
V
A
P
D
V
V
A
K
R
V
LG
Q
R
V
L
A
I
Y
V
A
A
A
A
E
P
I
E
D
TSD
R
L
R
W
R
V
G
D
S
C
R
P
V
D
R
--
A
E
W
W
E
Y
Q
-
R
A
Q
S
G
F
---
D
P
M
A
Q
V
T
T
A
T
L
G
-
D
-
A
R
P
A
A
L
A
L
A
R
K
W
D
P
A
F
A
E
L
T
D
E
E
L
L
R
G
I
GALDA
E
G
F
L
S
Q
A
G
K
L
L
F
T
S
L
D
R
T
A
I
E
-----
L
S
I
F
D
V
HGGQ
V
L
N
R
V
V
P
E
P
E
K
S
C
L
E
Q
L
D
Y
L
E
Q
A
L
N
V
V
N
KN
V
P
-
E
I
------------------------
P
R
L
----
A
V
R
E
A
M
L
N
A
M
I
H
-
R
-----
D
W
N
R
---
S
E
P
-------------------------
I
D
V
R
W
I
-
E
L
D
S
T
L
I
V
R
S
P
-
G
G
-
F
P
A
A
I
T
S
E
N
V
LS
N
R
A
----------------------
A
R
Y
P
A
L
A
D
L
Y
R
---------------
A
L
G
L
V
D
K
--------
Q
------
G
V
G
V
D
R
M
Y
Q
A
M
I
A
L
G
H
---
R
P
P
---------
T
I
E
--
E
I
A
G
------
P
F
V
E
T
---
T
L
V
G
G
RPV
L
P
V
L
E
----
L
V
S
-------
S
I
--
V
P
-
E
A
R
Q
D
D
Y
R
I
A
-----------
I
V
L
Y
L
L
F
Q
R
P
F
I
T
---------------
I
D
V
-
V
A
R
G
L
Q
S
G
K
E
A
A
R
N
A
L
E
A
--
A
R
Q
T
T
V
AGAP
L
I
-
I
A
H
--
D
GV
W
L
L
G
N
A
C
R
E
I
L
R
K
V
E
P
S
P
F
S
P
V
R
Y
L
S
----
T
D
Q
A
E
L
T
N
-
A
A
M
L
W
L
S
E
V
-
G
-
D
L
A
T
S
D
L
M
A
M
----------------------
C
G
V
S
R
G
T
------
A
K
A
C
V
D
G
L
V
D
E
E
R
V
V
A
V
G
----
G
G
R
S
R
R
Y
R
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
54.78
18%
-2
- C4 -
-
5L9W
1
APCD_AROAE
A:
[2-684]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIPT
L
E
Q
K
L
T
W
L
KPAPAS
S
R
E
L
D
L
A
A
Q
ID
P
A
Q
F
E
I
G
F
Q
R
T
N
D
I
L
D
E
G
M
D
V
F
V
R
S
C
R
C
A
M
G
V
A
G
D
S
L
V
A
I
M
T
A
D
G
D
I
V
N
G
S
C
G
T
Y
L
H
A
V
I
P
P
L
I
I
K
Y
I
L
E
T
Y
--------
G
D
E
-
I
----
R
D
G
D
L
W
F
A
N
DAVYGGVHNP
D
Q
-
M
-
V
C
M
P
V
Y
---
Y
E
-
G
K
L
V
A
W
T
A
A
L
V
H
T
T
E
------
T
G
A
I
E
P
G
G
M
P
V
S
--------
A
T
T
--------
R
--
F
E
E
G
M
N
L
-
P
P
M
R
I
G
ENF
K
L
-
R
E
D
V
V
S
M
F
V
-
A
-
F
G
L
R
A
P
S
M
I
A
V
-
D
L
K
A
R
C
T
T
A
D
R
V
R
T
R
I
-----
I
E
L
C
E
R
E
-----
G
A
D
Y
V
T
G
L
F
-----
R
K
M
L
Q
V
----
A
E
A
G
A
R
E
L
I
E
Q
W
P
-
D
G
K
Y
R
C
V
T
F
S
D
A
V
G
--
L
K
Q
G
L
V
R
--
S
--
C
Y
M
-------
T
L
E
K
K
G
--
D
R
----
M
L
V
D
L
-
S
E
T
-
G
P
-
E
TPSPY
N
A
H
P
---
Q
A
A
I
A
H
F
S
N
Y
I
Y
E
YLFHSLPISN
G
T
F
AN
I
D
F
K
F
G
K
N
T
C
L
S
P
D
P
R
A
A
-
T
S
-
C
S
V
M
I
S
T
G
V
M
--
S
A
V
----------------------
H
N
A
C
A
K
A
M
F
S
T
SLWKQSGASMGNGGN
A
L
V
L
A
G
Q
--------
N
QWG
S
S
F
A
D
M
L
A
Y
---
S
-
I
N
T
E
G
Q
GA
R
P
T
EDGMDAFGF
P
W
C
--
V
F
-
G
R
A
P
N
T
E
S
V
E
N
E
---
F
P
L
-------
L
V
P
LSNH
W
K
D
-------
S
C
--
G
H
-
G
K
Y
R
G
G
V
G
T
A
Q
V
W
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AHHVP
E
L
Y
M
M
A
I
A
D
N
T
K
L
Q
T
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Q
P
L
FG
G
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A
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T
V
P
G
I
G
I
-
R
N
A
N
I
K
E
L
M
A
E
G
S
D
-
K
I
K
--
L
D
V
E
T
L
----
L
A
-
E
R
T
ID
G
--
K
Y
E
I
E
F
Q
G
R
S
V
R
P
Y
S
N
G
-
E
V
V
T
F
A
F
S
C
G
G
T
G
Y
G
D
P
L
D
R
D
P
-----
K
S
V
-
E
V
D
L
L
K
G
V
L
-
T
-----------------------
E
Q
T
A
Q
N
I
YKVKWD
A
N
L
R
R
V
D
L
D
E
T
S
R
L
R
A
A
E
H
D
A
R
R
K
R
G
V
P
Y
E
Q
F
E
R
E
W
L
K
QRPDDEILKYYGTWPDAKVAQPLLRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
54.72
12%
-103
- C5 -
-
5CKW
1
?
B:
[6-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
K
L
L
R
F
H
E
L
K
S
---
L
P
G
M
D
E
K
A
L
E
L
L
I
K
V
L
G
N
K
G
I
R
K
L
I
--------
K
S
-------
A
D
G
K
--
P
I
S
----------
R
E
-
I
-
M
I
H
E
F
G
---
I
D
-
C
Q
I
L
F
I
T
T
E
A
---
S
L
------
K
P
I
I
V
P
T
E
N
K
I
S
--------
Y
C
E
--------
Q
--
F
K
V
Y
A
----------------------
L
D
-
D
-
G
K
T
Y
F
L
K
S
V
K
I
-
D
-----
A
E
S
L
T
E
F
T
N
E
-----
K
D
T
L
S
K
L
G
R
L
V
G
T
F
F
N
E
Q
T
Q
V
-----
H
Y
I
L
T
T
----
F
I
K
G
I
D
L
S
R
Y
K
N
A
L
P
L
N
V
N
L
K
H
F
W
E
V
L
G
--
I
M
-
I
S
V
C
--
H
--
Q
V
K
-------
Q
F
H
E
L
G
L
-----------------------------------------------------------------
I
H
R
D
L
K
P
G
N
I
M
L
D
A
-
D
M
-
Q
C
H
L
V
D
F
G
S
S
--
S
S
D
----------------------
K
E
P
K
P
A
S
W
--------------------
G
T
A
S
Y
--------
L
------
A
P
E
L
N
A
---
Q
--
E
D
F
I
---
A
F
S
---------
Q
V
S
--
D
L
-
F
------
A
L
A
Y
S
---
L
D
E
-------
L
F
N
----
P
F
R
-------
Q
V
--
K
F
-
A
K
V
D
I
G
I
K
N
K
-----------
H
L
V
L
L
H
A
E
I
---
E
A
------------
C
I
T
G
L
-
M
S
N
E
T
S
V
R
T
L
Y
F
S
R
I
L
Q
L
--
Q
R
V
P
E
S
----
F
---
K
S
--
R
--
P
E
A
F
T
Y
L
I
M
L
L
T
Q
W
K
S
C
-
Y
E
A
P
E
M
N
K
----
E
L
D
E
I
I
A
E
-
I
-----
K
V
A
-
Y
E
N
--------------------------------
H
E
Q
D
A
V
------
K
I
I
T
L
L
E
Q
L
S
K
A
D
G
L
L
N
S
H
K
A
L
L
S
V
L
I
K
S
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
SP3
43.73
5%
-10
- C5 -
-
1APM
1
KAPCA_MOUSE
E:
[10-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-
Q
E
S
V
K
E
F
-----
L
A
K
------
A
K
E
D
F
L
K
K
W
E
T
P
--------
S
Q
N
--------
T
AQ
L
D
Q
F
D
R
I
-
K
T
L
G
T
G
---
S
F
-
G
R
V
M
L
V
K
H
K
-
E
S
G
N
H
Y
A
M
K
I
L
---------------------------------------
D
K
Q
K
V
V
-----
K
----------------
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
--
L
V
-
K
L
E
F
--
S
--
F
K
D
NSNL---
Y
M
V
M
E
Y
V
A
G
G
----
E
M
F
S
H
-
L
R
R
-
I
G
-
R
F----
A
E
P
H
---
A
R
F
Y
A
A
Q
I
V
L
T
F
E
----------
Y
L
H
--
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
-
Q
G
-
Y
I
Q
V
T
D
F
G
F
A
--
K
R
V
----------------------
K
G
------------------------------------------------------------------
R
T
---------
W
T
L
--
C
G
-
T
------
P
E
Y
L
A
---
P
E
I
-------
I
L
S
----
K
G
Y
-------
N
K
--
A
V
-
D
W
W
A
L
G
V
L
I
Y
-----------
E
M
A
A
------
G
Y
P
P
FFA---------
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
G
K
---
V
R
F
P
S
H
--
F
S
--
S
D
----
L
K
-
D
L
L
--
R
--
N
L
L
Q
V
D
--
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
----
H
-----
K
W
-
F
-----
A
T
T
D
W
I
A
I
Y
Q
R
K
V
-
E
APFIPKFKGPGDTSNFDDYEEEE
I
R
V
S
I
N
E
------
K
C
G
K
E
F
T
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
43.57
15%
-62
- C5 -
-
5H0B
1
HCK_HUMAN
A:
[119-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
--------
G
G
F
Y
I
----
S
P
R
S
T
F
S
T
L
----------
Q
E
-
L
-
V
D
H
Y
K
K
---
G
N
-
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
------
P
Q
K
P
W
E
K
D
A
W
E
I
--------
P
R
E
--------
S
--
L
K
---
L
E
-
K
K
L
G
A
G
---
Q
F
-
G
E
V
W
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
-
G
S
M
S
V
--------------------------------------------------------
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
----
D
K
L
V
K
--
L
H
-
A
V
V
T
--
K
--
E
P
I
-------
Y
I
I
T
E
F
M
A
K
G
----
S
L
L
D
F
-
L
K
S
-
D
E
-
G
S
----
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
-
M
A
----------
F
I
E
--
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
-
S
L
-
V
C
K
I
A
D
F
G
L
A
--
R
V
I
----------------------
E
D
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
43.14
13%
-85
- C4 -
-
1B6R
-
PURK_ECOLI
A:
[1-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
A
A
V
P
F
Q
Q
S
V
I
T
A
E
I
E
--------
R
W
P
E
T
----
A
L
T
R
Q
L
A
R
H
----------
P
A
-
F
-
V
N
R
D
V
F
---
P
I
-
I
A
-----------
D
R
------
L
T
Q
K
Q
L
F
D
K
L
H
L
--------
P
T
A
--------
P
--
W
Q
L
L
A
E
R
-
S
--------
E
W
-
P
A
V
F
D
R
L
-----
G
E
L
A
I
V
K
R
R
T
G
-
Q
W
R
L
R
A
N
E
T
E
Q
L
P
A
E
C
----------
Y
G
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
-----
S
L
V
G
A
R
----
G
F
D
G
---------------
S
T
V
F
Y
P
L
T
H
--
N
L
-
H
Q
D
G
--
I
--
L
R
T
-------
S
V
A
F
P
Q
A
N
A
Q
----
Q
Q
A
R
A
-
E
E
M
-
L
S
-
A
-----
I
M
Q
E
---
L
G
Y
-
V
G
V
M
A
M
E
C
F
----------
V
T
-------------
P
Q
G
L
L
I
N
E
-
L
A
-
P
R
V
-----------------------------------------------------------------
H
N
--------
S
------
G
H
W
T
Q
N
---
G
-----------------------
A
--
S
I
-
S
------
Q
F
E
L
H
---
L
R
A
-------
I
T
D
--------------------------------------------
L
P
L
P
Q
P
V
V
N
N
P
S
------------
V
M
I
N
L
-
I
G
S
D
------------------
V
N
Y
D
----
W
L
-
K
L
P
--
L
--
V
H
L
H
W
Y
D
K
E
V
R
P
G
R
K
V
G
-
H
L
N
L
T
D
-
S
----
D
T
S
R
L
T
A
T
-
L
-----
E
A
L
-
I
P
L
L
P
--------------------------------------------------------------
P
E
Y
A
S
G
V
I
W
A
Q
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
42.24
15%
-69
- C5 -
-
1AD5
1
HCK_HUMAN
A:
[116-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
H
Y
K
I
R
T
L
D
N
--------
G
G
F
Y
I
----
S
P
R
S
T
F
S
T
L
----------
Q
E
-
L
-
V
D
H
Y
K
K
---
G
N
-
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
------
P
Q
K
P
W
E
K
D
A
W
-----------
E
I
--------
P
--
R
E
S
L
K
L
E
-
K
K
L
G
A
G
---
Q
F
-
G
E
V
W
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
-
G
S
M
S
V
-----
E
---------------------------------------------------
A
F
L
A
E
A
N
V
M
K
T
L
Q
----
H
D
K
L
V
K
--
L
H
-
A
V
V
T
--
K
--
E
P
I
-------
Y
I
I
T
E
F
M
A
K
G
----
S
L
L
D
F
-
L
K
S
-
D
E
G
S
-----
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
-
M
A
----------
F
I
E
--
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
-
S
L
-
V
C
K
I
A
D
F
G
L
A
--
R
V
G
----------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
SP3
40.89
7%
-7
- C5 -
-
1PMN
1
MK10_HUMAN
A:
[8-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
Q
F
Y
S
V
E
V
G
D
S
--------
T
F
T
--------
V
--
L
K
R
Y
Q
N
L
-
K
P
I
G
S
G
---
A
Q
-
G
I
V
C
A
A
Y
D
A
V
L
-
D
R
N
V
A
I
K
K
L
S
R
-
P
F
Q
N
-------------------------------------------
Q
T
H
A
K
R
----
A
Y
R
E
L
V
L
M
K
C
----------
V
N
H
K
N
I
I
S
--
L
L
-
N
V
F
T
--
P
--
Q
K
T
LEEF
Q
D
V
Y
L
V
M
E
L
M
D
-
A
----
N
L
C
Q
V
-
I
Q
--
M
E
-
L
-----
D
H
E
R
---
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
----------
H
L
H
--
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
-
D
C
-
T
L
K
I
L
D
F
G
L
A
--
S
F
M
MTP
Y
V
V
T
RYYRA
P
E
V
I
L
GMGYK
E
N
V
D
I
W
S
V
G
C
I
---------------
M
G
E
M
V
R
H
KILFPGRD
Y
------
I
D
Q
W
N
K
---
V
-
I
E
Q
L
G
---
T
P
C
---------
P
E
F
M
K
K
L
-
Q
------
P
T
V
R
N
---
Y
V
E
-------
N
R
P
----
K
Y
A
-------
G
L
--
T
F
-
P
K
L
----
F
P
D
-----------
S
L
F
P
A
D
S
E
H
N
K
L
K
A
------------
S
Q
A
R
D
-
L
L
S
K
M
L
-------
V
I
D
P
A
KR
I
S
V
D
D
A
----
L
Q
H
P
Y
I
--
N
--
V
W
Y
D
P
A
E
V
E
A
P
Q
L
D
E
R
E
-
H
T
I
E
E
W
K
E
----
L
I
Y
K
E
V
M
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
40.39
15%
-10
- C6 -
-
3QMZ
-
DYHC_YEAST
A:
[1364-4092]
E
F
V
I
E
K
S
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M
32
Fugue
39.52
16%
-6
- C3 -
-
4U6D
20
?
A:
[28-409]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
F
P
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------------------------------------
T
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------
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R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------