@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K0HVN5_9BURK: (2019-01-30 )
MHPTPSPDTILFASHTTATAASVAQWVERHYDLPVQQCYLIRRNLNDNYAVRAADGSRYVARLCAIRPRGPFNVDFEVALLAHLEAQGVGVASPVLAANGATSVALPFPEGPRVLVLFRHCEGSVPDTPEDLHLTGATLAQIHSAAQSYTGPASRYVLDGHHLAGRTLDYLAAHPELAPSVLDAYRELIHRLLGELANVEDTLTRVMCHGDTHGFNNHVYSDAEGARRAAFFDFDDAGPGFLAYDLCVWLWSNLPRKAPMEPDEALLQRWQQYLAGYRAGGGHVTDADLAALPLFVQLRHLWNMGEGVARIHHWGANMMSVDWIKKQLEVMAAWARLDLPA
Atome Classification :
(20 SA)
----.........10........20........30.-----.-------.--.....40.---..-.-...--.50..-..--------.--------.-..60..-.--.....-70....-.....80.....-..-.90.........100......--.110........120.-.--...-----..--130-....-...140.......150.--.--.-------.-.-.----.---160--.-.---..-..-..170---..-.------.-.-----------.---.------.------.------180-----........190.....-----.------.--200----..-----.--------------.--....210.......220-.---.--......230.......240....--..-.250-------.......--------260--.----.--------....-...-270-......-----.--280..-------------.-----....290...-.....300......-----..-310.--..--...---.320.......330.....--..340-------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MHPTPSP
D
T
I
L
F
ASHTT
A
T
A
A
S
V
A
Q
W
V
E
R
HYD-----L-------
P
--
V
Q
Q
C
Y
L
I
R
---RN-L-NDN--
Y
A
V
R
A-AD--------G--------
S
-
R
Y
V
A
R
L
-
C
--AIRPR-G-PFNV-
D
F
E
V
A
L
L
A
H
L
EA-QG-VG-VASPVLAANGA
T
S
V
A
L
PF--PEG-
P
R
V
L
V
L
F
RHCEG-S--VPD-----TP--EDL-HL
T
G
-
A
T
L
A
Q
I
H
S
A
A
Q
SYTGPA--S--
R
-------
Y
-
V
-L----D---GH---H-L---AG-R
T
-
L
D
Y
-----
L
A-A------H-P-----------E---L------
A
------
P
------
S
V
------
L
D
A
Y
R
E
L
I
H
R
L
L
G
E
L
A
-----
N
------
V
--
E
D
-----
T
L
-----
T
--------------
R
--
V
MCHGDTHGFNNHVYS--D---A--EGA
R
R
A
A
F
F
DFDDAGP
G
F
L
A
Y
D
L
--
C
V
-
W
L
W
S-------NLPRKAP--------M----E----
P
--------
D
E
A
L
-
L
Q
R
-
W
Q
Q
-
Y
L
A
G
YR-----A--GGGHV-------------T-----
D
A
D
L
A
A
-
L
P
L
-
F
V
Q
L
R
H
L
-
W
NM
G
E
G
-----
V
A
-
R
I
H
H--WG--ANM---
M
S
V
D
W
I
K
K
Q
L
E
V
M
A
A
W
A
RL--DLPA--------------------
1
PsiBlast_PDB
90.85
27%
-64
- C3 -
-
6EF6
2
?
A:
[29-307]
-------------------------
T
I
A
Q
Q
A
L
T
H
Y
D
-----
V
-------
S
---
D
N
A
S
L
R
L
---
L
N
-
L
-
S
E
N
--
A
T
Y
L
V
-
E
D
--------
G
--------
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H
Q
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R
V
-
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--
R
Q
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Y
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-
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-
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H
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S
E
L
D
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L
A
A
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R
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-
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S
D
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T
-
V
P
T
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
--
A
D
-V
P
R
H
V
V
H
F
E
M
V
G
G
-
A
--
E
P
D
EESL-
T
L
--
D
D
F
-
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
S
Q
R
W
T
R
P
A
--
G
F
G
R
-------
F
-
S
-
W
----
D
---
W
E
---
H
-
C
---
L
G
-
D
T
-
P
R
W
GRWQD
A
E
-
G
------
V
-
G
-----------
A
---
S
------
E
------
T
------
A
L
------
L
T
R
A
Q
D
L
L
H
R
K
L
E
E
Y
G
-----
S
------
G
--
P
D
-----
R
Y
-----
G
------------------
L
I
H
A
D
L
R
-
L
A
N
L
L
V
D
--
S
---
S
--
T
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
-
S
F
I
E
-------
H
D
P
R
-----------------------------------
L
G
E
-
W
Q
E
S
W
V
A
G
Y
R
-----
S
---
R
R
E
L
-------------
P
-----
A
A
D
E
A
M
-
L
P
S
-
F
V
---------------------------------------------------------------------------------
30
HHSearch
81.55
26%
-30
- C3 -
-
6EF6
2
?
A:
[27-323]
-----------------------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
-----
V
-------
S
D-
N
A
S
L
R
L
L
N
---
L
S
-
E
-
N
A
T
--
Y
L
V
E
--
D
G
--------
E
--------
H
-
Q
S
I
L
R
V
-
H
--
R
Q
D
Y
H
-
Q
-
P
H
E
I
-
E
S
E
L
D
W
L
A
A
L
R
T
D
S
D
-
V
T
-
V
P
T
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
D--
V
-
P
R
H
V
V
H
F
E
M
V
G
G
-
A
--
E
P
D
EESL-
T
L
--
D
D
F
-
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
S
Q
R
W
T
R
P
A
G
F
G
--
R
-------
F
-
S
-
W
----
D
---
W
E
---
H
-
C
---
L
G
-
D
T
--
P
R
-----
W
G
-
R
------
W
-
Q
-----------
D
---
A
------
E
GVG---
A
------
S
E
------
T
A
L
L
T
R
A
Q
D
L
L
H
R
K
L
E
-----
E
------
Y
G-
S
G
-----
P
D
-----
R
--------------
Y
--
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
--
S
TPQ
R
------
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
--
G
T
-
A
V
S
F
-------
I
E
H
D
-------------------------------
P
R
L
-
G
E
W
-
Q
E
S
-
W
V
A
G
Y
R
-----
S
--
R
-
R
E
L
-------------
P
-----
A
A
D
E
A
M
-
L
P
S
-
F
V
F
L
R
R
L
-
L
L
L
A
W
M
-----
G
S
-
H
T
H
----------------------------------------------------------
63
Fugue
80.97
18%
-13
- C3 -
-
4OCV
2
?
A:
[24-378]
----------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
G
T
V
D
S
I
E
P
Y
G
D
-----
G
-------
H
--
I
N
T
T
Y
L
V
T
---
T
----------------
D
--------
G
--------
P
-
R
Y
I
L
Q
R
-
M
NT
G
I
F
P
D
-
T
-
V
N
L
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
I
D
---
G
G
A
-
W
R
V
Y
K
F
I
E
H
T
M
S
-
Y
NL
V
P
N
------
P
--
D
V
F
-
R
E
A
G
-
R
A
F
G
D
F
Q
N
F
L
S
G
F
D
A
N
Q
--
L
--
T
-------
E
-
T
-
I
----
A
---
H
F
---
H
D
T
---
P
H
-
R
F
-
E
D
F
-----
K
K
-
A
------
L
-
A
-----------
A
---
D
------
E
LGR---
A
------
A
G
------
C
G
P
E
I
E
F
Y
L
S
H
A
D
Q
Y
A
-----
V
------
V
--
M
D
-----
G
L
R
D
GSI
P
--------------
L
--
R
V
T
H
N
D
T
K
--
L
N
N
I
L
M
--
D
---
A
--
T
T
G
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
--
G
D
-
S
I
R
F
GASTALE
D
E
R
D
L
D
K
--------
V
----
H
----
F
--------
S
T
E
L
-
F
R
A
-
Y
T
E
-
G
F
V
G
E
L
R
DSIT
A
--
R
E
A
E
L
-------------
L
-----
P
F
S
G
N
L
-
L
T
M
-
E
C
G
M
R
F
L
-
A
D
Y
L
E
G
DVYFA
T
K
-
Y
P
E
H
--
N
L
--
V
R
S
---
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
--
I
V
A
D
V
M
E
T
T---------------
32
HHSearch
74.33
21%
-32
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-285]
-------------------
T
D
I
T
E
D
E
L
R
N
F
L
-
T
Q
Y
D
-----
V
-------
G
S-
L
T
S
Y
K
G
I
A
---
E
----
N
S
N
--
F
L
L
H
--
T
T
--------
K
--------
D
-
P
L
I
L
T
L
-
Y
--
E
K
------
K
N
D
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
-
L
S
-
C
P
L
P
L
P
R
K
D
G
E
L
L
G
E
L
------
S
-
G
R
P
A
A
L
I
S
F
L
E
G
-
M
--
W
L
R
KP---
E
A
--
K
H
C
-
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
E
G
F
E
I
K
R
--
P
--
N
-------
A
L
S
V
D
----
G
---
W
K
---
V
-
L
---
W
D
-
K
S
-
E
E
R
-----
A
D
-
E
------
V
----------------------------------------------
E
K
G
L
R
E
E
I
R
P
E
I
D
Y
L
A
-----
A
------
H
W-
P
K
-----
D
L
-----
P
--------------
A
--
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
------
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
--
S
I
-
C
L
N
A
-------
W
C
F
E
K
--------------------
D
--------
G
A
Y
N
-
V
T
K
-
G
K
A
-
L
L
E
G
Y
Q
-----
S
--
V
-
R
P
L
-------------
S
-----
E
A
E
L
E
A
-
L
P
L
-
L
S
R
G
S
A
L
-
R
F
F
L
T
R
-----
L
Y
-
D
W
L
----------------------------------------------------------
51
Fugue
73.97
14%
-48
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-------
S
A
F
T
-------
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
-----
R
-------
V
--
D
S
G
L
T
P
L
N
---
S
Y
-
E
-
N
R
V
--
Y
Q
F
Q
D
-
E
D
--------
R
--------
R
-
R
F
V
V
K
F
-
Y
--
R
P
E
R
W
-
T
-
A
D
Q
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
-
V
P
-
V
A
A
P
V
A
F
N
G
Q
T
-----
L
L
--
N
H
Q
-
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
--
Q
F
E
-----
A
D
N
I
D
Q
M
-
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
R
K
Q
L
-
F
I
--
H
--
R
-------
P
-
T
-
I
----
G
---
L
N
---
E
-
Y
---
L
I
-
E
P
-
R
K
L
-----
F
E
-
D
------
A
-
T
-----------
L
---
I
------
P
------
S
------
G
L
------
K
A
A
F
L
K
A
T
D
E
L
I
A
A
V
T
-----
A
------
H
W-
R
E
-----
D
F
-----
T
--------------
V
--
L
R
L
H
G
D
C
H
A
G
N
-----------
I
--
L
W
R
D
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
--
W
M
-
L
L
N
G
-------
D
--
K
A
E
Q
--------
R
----
M
----
Q
--------
L
E
T
I
-
I
E
A
-
Y
E
E
-
F
S
E
---------------
F
-------------
D
-----
T
A
E
I
G
L
-
I
E
P
-
L
R
A
M
R
L
V
-
Y
Y
L
A
W
------
L
M
-
R
R
W
A
--
D
P
--
A
F
P
---
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
--
I
E
Q
A
K
V
L
Q
EPPLQLTPMY------
31
HHSearch
72.69
16%
-35
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[6-315]
----------------
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
-
H
G
-----
I
-------
R
V-
D
S
G
L
T
P
L
N
---
S
Y
-
E
-
N
R
V
--
Y
Q
F
Q
D
-
E
D
--------
R
--------
R
-
R
F
V
V
K
F
-
Y
--
R
P
E
R
W
-
T
-
A
D
Q
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
-
V
P
-
V
A
A
P
V
A
F
-
N
G
Q
T
L
L
N
------
H
Q
-
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
--
Q
F
E
AD---
N
I
--
D
Q
M
-
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
R
K
Q
L
F
I
H
-----
R
-------
P
-
T
-
I
----
G
---
L
N
---
E
-
Y
---
L
I
-
E
P
-
R
K
L
-----
F
E
-
D
------
A
-
T
-----------
L
---
I
------
P
------
S
------
G
L
------
K
A
A
F
L
K
A
T
D
E
L
I
A
A
V
T
-----
A
------
H
W-
R
E
-----
D
F
-----
T
--------------
V
--
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-------------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
--
W
M
-
L
L
N
G
-------
D
K
A
---------------------------------
E
Q
-
R
M
Q
-
L
E
T
-
I
I
E
A
Y
E
-----
E
--
F
-
S
E
F
-------------
D
-----
T
A
E
I
G
L
-
I
E
P
-
L
R
A
M
R
L
V
-
Y
Y
L
A
W
L
-----
M
R
-
R
W
A
D
P
A
F
P
--
K
N
F
PWL
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
---------------------------
33
HHSearch
67.53
22%
-26
- C3 -
-
4PDY
1
?
A:
[21-306]
------------------------
P
L
I
P
Q
A
V
V
S
K
Y
D
-----
L
-------
A
--
I
Q
Q
R
--------
H
-
A
-
D
G
N
--
I
E
V
W
T
-
D
S
K-------
G
--------
R
-
R
Y
A
A
K
R
-
S
--
S
I
A
-----
P
A
H
C
-
R
I
M
V
Q
C
L
R
H
A
Q
E
-
Q
G
-
F
T
K
F
A
R
F
V
T
T
S
S
N
A
P
Y
V
R
H
------
G
-
D
F
T
Y
Y
V
T
E
W
V
S
G
-
Q
--
P
A
N
FG---
L
P
--
E
H
V
-
A
Q
T
A
-
Y
T
L
A
Q
F
H
E
A
T
R
S
F
R
T
D
W
--
K
------------------------
D
---
D
-
V
F
G
L
F
Q
-
A
R
-
W
R
D
-----
L
R
-
Q
------
M
-
W
L
G
A
--------
D
R
K-
R
EK----
D
A
F
D
Q
L
L
L
------
S
M
------
R
D
E
L
H
R
D
A
A
E
S
L
A
L
F
E
-----
D
R
D
V
I
A
Y
L
E
-
A
E
-----
R
S
-----
S
--------------
G
--
G
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
--
Q
---
H
------
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
L
D
M
--
A
H
-
L
L
R
R
-------
S
L
E
R
------------------------------
G
N
W
D
-
G
H
L
-
A
Y
A
-
C
F
L
H
F
D
-----
A
--
V
-
R
N
I
-------------
P
-----
K
S
E
Y
R
A
-
V
E
A
-
I
L
R
F
P
Y
L
-
P
W
-------------------------------------------------------------------------
34
HHSearch
65.48
16%
-55
- C3 -
-
2Q83
4
COTI_BACSU
A:
[18-307]
----------------------
K
L
T
E
L
A
E
N
V
L
Q
G
W
D
-----
V
-------
Q
--
A
E
K
I
D
V
I
Q
--------
A
L
V
--
W
K
V
H
--
T
D
--------
S
--------
G
-
A
V
C
L
K
R
-
I
--
H
R
P
-----
E
K
K
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
-
M
N
-
V
P
G
I
L
P
N
K
K
G
S
L
Y
S
K
H
------
G
-
S
F
L
F
V
V
Y
D
W
I
E
G
-
R
--
P
F
E
LT---
V
K
--
Q
D
L
-
E
F
I
M
-
K
G
L
A
D
F
H
T
A
S
V
G
Y
Q
P
P
N
--
G
--
V
-------
P
-
I
-
F
T
KLG
R
---
W
P
---
N
-
H
---
Y
T
-
K
R
-
C
K
Q
-----
M
E
-
T
------
W
-
K
-----------
L
---
M
A
E
A
E
KE
D
------
P
F
S
Q
L
Y
L
Q
E
------
I
D
G
F
I
E
D
G
L
R
I
K
D
R
L
L
Q
ST
Y
V
P
------
W
T
E
Q
L
-----
K
K
-----
S
--------------
P
--
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
--
N
---
E
------
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
--
R
K
-
M
I
I
P
-------
L
L
D
T
T
-----------------------------
G
V
W
D
-
D
E
T
-
F
N
V
-
M
L
N
A
Y
E
-----
S
--
R
-
A
P
L
-------------
T
-----
E
E
Q
K
Q
V
-
M
F
I
-
D
M
L
F
P
Y
-----------------------------------------------------------------------------
37
HHSearch
64.53
17%
-11
- C3 -
-
4WH3
8
NAHK_BIFL2
A:
[8-306]
---------------------------
L
F
G
I
A
S
H
F
A
-----
L
EG-----
A
--
V
T
G
I
E
P
Y
G
---
D
G
H
I
-
N
T
T
--
Y
L
V
T
--
T
D
--------
G
--------
P
-
R
Y
I
L
Q
Q
-
M
--
N
T
S
I
F
P
D
T
V
N
L
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
L
D
I
V
P
T
T
S
G
A
T
W
A
E
I
------
D
-
G
G
A
W
R
V
Y
K
F
I
E
H
-
T
--
V
S
Y
NLVP-
N
P
--
D
V
F
-
R
E
A
G
-
S
A
F
G
D
F
Q
N
F
L
S
E
F
D
A
S
Q
--
L
--
T
E------
T
-
I
-
A
----
H
---
F
H
D
T
P
H
-
R
---
F
E
-
D
F
-
K
A
A
-----
L
A
-
A
DKLG--
R
-
A
-----------
A
---
A
------
C
------
Q
------
P
E
------
I
D
F
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
-----
G
------
L
R
-
D
G
-----
S
I
-----
P
--------------
L
--
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
------
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
--
G
D
-
S
I
R
F
-------
G
A
S
T
A
L
E
--------
D
----
E
KDLS
K
--------
V
H
F
S
-
T
E
L
-
F
R
A
-
Y
T
E
G
F
V
-----
G
E
L
R
-
G
S
I
-------------
T
-----
A
R
E
A
E
L
-
L
P
F
-
S
G
N
L
L
T
M
-
E
C
G
M
R
----------------------------------------------------------------------
39
HHSearch
63.04
11%
-23
- C3 -
-
5FUT
10
CHKA_HUMAN
A:
[9-375]
-----------------------
R
R
R
A
Y
L
W
C
K
E
F
L
P
-----
G
AWRGLRE
D
--
E
F
H
I
S
V
I
R
---
G
G
L
S
-
N
M
L
--
F
Q
C
S
L
-
P
D
TTATLGDE
P
--------
R
-
K
V
L
L
R
L
-
Y
--
G
------G
A
E
A
M
-
V
L
E
S
V
M
F
A
I
L
A
E
-
R
S
-
L
G
--
P
K
L
Y
G
I
F
P
Q
-----------------
G
R
L
E
Q
F
I
P
S
-
R
--
R
L
D
TEELS
L
P
--
D
I
S
-
A
E
I
A
-
E
K
M
A
T
F
H
G
M
K
M
P
F
N
K
E
P
--
K
--
W
-------
L
-
F
-
G
----
T
---
M
E
---
K
-
Y
---
L
K
-
E
V
-
L
R
I
-----
K
F
-
T
------
E
-
E
-----------
S
---
R
------
I
------
K
------
K
L
------
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
-----
S
------
L
L
E
S
T
-----
P
S
-----
P
--------------
V
--
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
--
G
---
R
EN
S
E
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
--
G
N
-
H
F
C
E
-------
W
M
Y
D
Y
S
Y
EKYPF
F
R
A
N
----
I
----
R
--------
K
Y
P
T
-
K
K
Q
-
Q
L
H
-
F
I
S
S
Y
L
-----
P
--
A
-
F
Q
N
DFENLS
T
E
E
K
S
I
I
K
-----
E
E
M
L
L
E
-
V
N
R
-
F
A
L
A
S
H
F
-
L
W
G
L
W
S
-----
I
V
-
Q
A
K
I
--
S
S
--
I
E
F
---
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
--------------------------
54
Fugue
60.41
13%
-28
- C3 -
-
3I1A
2
?
A:
[3-330]
------------------
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
-----
I
-------
D
--
I
H
T
A
Q
F
I
Q
G--
G
A
-
D
-
T
N
A
--
F
A
Y
Q
A
D
S
E
--------
S
--------
K
-
S
Y
F
I
K
L
-----
K
Y
G
Y
-
H
-
D
E
I
N
-
L
S
I
I
R
L
L
H
D
S
G
I
-
K
E
-
I
I
-
F
P
I
H
T
L
E
A
K
L
F
Q
Q
--------
L
K
-
H
F
K
I
I
A
Y
P
F
I
H
A
-
P
--
N
G
F
T
Q
N
L
-
T
G
--
K
Q
W
-
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
V
P
-
I
S
I
Q
--
Q
--
Q
-------
L
-
R
-
K
----
E
---
I
Y
---
S
-
P
---
K
W
-
R
E
-
I
V
R
-----
S
F
-
Y
------
N
-
Q
IEFDNSDD
K
L
T
A
---
A
------
F
------
K
------
S
F
------
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
-----
K
------
L
--
S
K
K
IQPD
L
D
-----
K
--------------
Y
--
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---------
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
--
M
F
-
I
G
G
G
-------
V
G
N
V
W
N
K
--------
P
----
H
----
E
--------
I
Q
Y
F
-
Y
E
G
-
Y
G
E
-
I
----------------
N
V
-------------
D
-----
K
T
I
L
S
Y
-
Y
R
H
-
E
R
I
V
E
D
I
-
A
V
Y
G
Q
D
-----
L
L
S
R
N
Q
N
--
N
Q
--
S
R
L
---
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
--
F
A
T
E
--------------------
35
HHSearch
60.06
16%
-9
- C3 -
-
4OCV
2
?
A:
[24-326]
----------------------
T
N
E
A
L
F
D
-
V
A
S
H
F
A
-----
L
-------
E
GT
V
D
S
I
E
P
Y
G
---
D
G
H
I
-
N
T
T
--
Y
L
V
T
--
T
D
--------
G
--------
P
-
R
Y
I
L
Q
R
-
M
--
N
T
G
I
F
P
D
-
T
V
N
L
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
I
------
D
-
G
G
A
W
R
V
Y
K
F
I
E
H
-
T
--
M
S
Y
NLVP-
N
P
--
D
V
F
-
R
E
A
G
-
R
A
F
G
D
F
Q
N
F
L
S
G
F
D
A
N
Q
--
L
--
T
-------
E
T
I
-
A
----
H
FHD
T
P
---
H
-
R
---
F
E
-
D
F
-
K
K
A
-----
L
A
-
A
------
D
E
L
-----------
G
RAA
G
------
C
------
G
------
P
E
------
I
E
F
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
-----
G
------
L
R
-
D
G
-----
S
I
-----
P
--------------
L
--
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
------
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
--
G
D
-
S
I
R
F
-------
G
A
S
T
A
L
E
--------
D
ERDL
D
----
K
--------
V
H
F
S
-
T
E
L
-
F
R
A
-
Y
T
E
G
F
V
-----
G
E
L
R
-
D
S
I
-------------
T
-----
A
R
E
A
E
L
-
L
P
F
-
S
G
N
L
L
T
M
-
E
C
G
M
R
----------------------------------------------------------------------
38
HHSearch
59.64
11%
-29
* C3 *
-
5FTG
11
CHKA_HUMAN
A:
[9-375]
-----------------------
R
R
R
A
Y
L
W
C
K
E
F
L
P
-----
G
AWRGLRE
D
--
E
F
H
I
S
V
I
R
---
G
G
L
S
-
N
M
L
--
F
Q
C
S
L
-
P
D
TTATLGDE
P
--------
R
-
K
V
L
L
R
L
-
Y
--
G
--------
E
A
M
-
V
L
E
S
V
M
F
A
I
L
A
E
-
R
S
-
L
G
--
P
K
L
Y
G
I
F
P
Q
-----------------
G
R
L
E
Q
F
I
P
S
-
R
--
R
L
D
TEELS
L
P
--
D
I
S
-
A
E
I
A
-
E
K
M
A
T
F
H
G
M
K
M
P
F
N
K
E
P
--
K
--
W
-------
L
-
F
-
G
----
T
---
M
E
---
K
-
Y
---
L
K
-
E
V
-
L
R
I
-----
K
F
-
T
------
E
-
E
-----------
S
---
R
------
I
------
K
------
K
L
------
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
-----
S
------
L
L
E
S
T
-----
P
S
-----
P
--------------
V
--
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
--
G
---
R
EN
S
E
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
--
G
N
-
H
F
C
E
-------
W
M
Y
D
Y
S
Y
EKYPF
F
R
A
N
----
I
----
R
--------
K
Y
P
T
-
K
K
Q
-
Q
L
H
-
F
I
S
S
Y
L
-----
P
--
A
-
F
Q
N
DFENLS
T
E
E
K
S
I
I
K
-----
E
E
M
L
L
E
-
V
N
R
-
F
A
L
A
S
H
F
-
L
W
G
L
W
S
-----
I
V
-
Q
A
K
I
--
S
S
--
I
E
F
---
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
--------------------------
52
Fugue
59.11
13%
-23
- C3 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
---------------
L
S
A
E
D
A
K
K
L
T
E
L
A
E
N
V
L
Q
G
W
D
-----
V
-------
Q
--
A
E
---
K
I
D
---
V
I
-
Q
-
A
L
V
--
W
K
V
H
T
-
D
S
--------
G
--------
A
-
V
C
L
K
R
I
-------
H
R
-
P
-
E
K
K
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
M
N
--
V
P
G
I
L
P
N
K
K
G
S
L
Y
S
K
H
------
G
-
S
F
L
F
V
V
Y
D
W
I
E
G
R
P
--
F
E
L
-----
T
V
--
K
Q
D
-
L
E
F
I
M
K
G
L
A
D
F
H
T
A
S
V
G
Y
Q
P
P
N
--
G
--
V
P
I
F
T
KLG
R
-
W
-
P
----
N
---
H
Y
---
T
-
K
---
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C
-
K
Q
M
E
T
W
-----
K
L
M
A
------
E
-
A
-----------
E
---
K
------
E
------
D
------
P
F
------
S
Q
L
Y
L
Q
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I
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G
F
I
E
D
G
L
-----
R
------
I
--
K
D
-----
R
L
-----
L
Q
ST
Y
V
P
W
T
E
Q
L
K
K
S
P
--
N
L
C
H
Q
D
Y
G
--
T
G
N
T
L
L
--
G
---
E
--
N
E
--
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
--
R
K
M
I
I
P
L
-------
L
D
T
T
G
V
W
--------
D
----
D
----
E
--------
T
F
N
V
M
L
N
A
-
Y
E
S
-
R
---------------
A
P
L
-------------
T
-----
E
E
Q
K
Q
V
M
F
I
D
M
L
F
P
Y
E
L
Y
-
D
V
I
R
E
K
-----
Y
V
-
R
K
S
A
--
L
P
--
K
E
E
---
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
--------------------------
36
HHSearch
58.50
15%
-18
- C3 -
-
3I1A
4
?
B:
[4-292]
-------------------
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
-----
I
-------
D
--
I
H
T
A
Q
F
I
Q
---
G
G
-
A
D
T
N
A
F
A
Y
Q
A
D
--
S
E
--------
S
--------
K
-
S
Y
F
I
K
L
-
K
--
Y
G
Y
H
-------
D
-
E
I
N
L
S
I
I
R
L
L
H
D
-
S
G
-
I
K
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
------
K
-
H
F
K
I
I
A
Y
P
F
I
H
A
-
P
--
N
G
F
T
Q
N
L
-
T
G
--
K
Q
W
-
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
--
Q
LR
K
-------
E
-
I
-
Y
SP--
K
---
W
R
---
E
-
I
---
V
R
-
S
F
-
Y
N
Q
-----
I
E
-
F
DNSDD
K
L
-
T
-----------
A
---
A
------
F
------
K
------
S
F
------
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
-----
K
L
S
K
K
--
I
Q-
P
D
-----
L
D
-----
K
--------------
Y
--
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
------
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
--
M
F
-
I
G
G
G
-------
V
G
N
V
W
-------------------------------
N
K
-
P
H
E
-
I
Q
Y
-
F
Y
E
G
Y
G
-----
E
--
I
-
N
V
----------------------
D
K
T
I
-
L
S
Y
-
Y
R
H
E
R
I
V
-
E
D
I
A
V
Y
---------------------------------------------------------------------
60
Fugue
58.00
17%
-19
- C3 -
-
3CSV
11
?
A:
[4-333]
---------------------
S
R
E
D
E
I
R
D
F
L
A
T
H
G
-----------------------
Y
A
---
D
W
-
N
-
R
T
P
--
R
Y
Q
R
L
-
R
S
--------
P
--------
T
-
G
A
K
A
V
L
M
D
--
W
S
P
E
E
-
G
-
G
-
D
T
-
Q
P
F
V
D
L
A
Q
Y
L
R
N
-
L
D
-
I
--
S
A
P
E
I
Y
A
E
E
H
A
R
G
L
L
L
I
E
--
D
L
G
-
D
A
------
L
F
T
E
-
V
--
I
N
N
-----
D
P
--
A
Q
E
M
P
L
Y
R
-
A
A
V
D
L
L
I
H
L
H
D
A
Q
T
P
E
L
--
A
--
R
-------
L
--------
D
---
P
E
---
T
-
L
---
S
E
M
T
R
-
L
A
F
-----
S
E
-
Y
------
R
-
Y
-----------
A
---
I
------
L
------
G
------
D
A
------
A
E
D
N
R
K
R
F
E
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R
F
A
Q
I
L
-----
S
------
A
--
Q
L
-----
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------
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--------------
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M-
V
F
V
H
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F
H
A
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N
L
L
W
L
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--
E
---
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--
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G
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
--
V
S
-
L
L
------------
Q
D
A
R
--------
R
----
D
----
V
--------
P
A
Q
V
-
E
A
Q
M
I
D
H
-
Y
I
Q
A
T
------------
G
V
-------------
D
-----
E
S
H
F
R
S
-
A
Y
A
-
V
I
A
V
Q
R
N
M
R
I
L
G
I
F
-----
A
R
-
L
S
Q
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--
F
G
KR
H
Y
I
---
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F
V
P
R
V
W
A
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F
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R
G
L
A
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P
A
L
--
A
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
69
SP3
57.91
10%
-39
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
--
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
GAWKT
V
-------
P
--
L
E
H
L
R
I
S
R
I
K
G
G
M
-
S
-
N
M
L
--
F
L
C
R
L
-
S
E
--------
V
YPPIRNEP
N
-
K
V
L
L
R
V
-
Y
---
F
N
P
E
-
T
-
E
S
H
L
-
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
-
L
--
G
P
K
L
Y
G
I
F
S
G
-----------------
G
R
L
E
E
Y
I
P
S
-
R
--
P
L
S
C
H
E
I
S
L
A
--
H
M
S
-
T
K
I
A
-
K
R
V
A
K
V
H
----
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L
E
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P
I
--
W
--
K
-------
E
-
P
-
D
----
Y
---
L
C
---
E
-
A
---
L
Q
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R
W
-
L
K
Q
-----
L
T
-
G
------
T
-
V
DAE
H
R
F
-----
D
---
L
------
P
------
E
------
E
C
GVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
S
-----
L
------
S
---------
K
S
-----
P
--------------
V
--
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
--
R
-----------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
--
A
N
-
H
F
I
E
-------
W
T
I
D
Y
D
I
--------
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----
E
----
A
PF
Y
K
I
Q
TE
N
F
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E
-
N
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Q
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M
L
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-
F
F
L
N
Y
L
-----
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--
E
Q
G
N
T
-------------
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L
Y
K
K
S
E
D
L
-
V
Q
E
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T
L
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F
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P
V
-
S
H
F
F
W
G
-----
V
W
-
G
L
L
Q
--
V
E
--
L
S
P
---
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA------------------
42
HHSearch
56.19
15%
-16
- C3 -
-
4R78
2
?
A:
[23-279]
------------------------
K
I
I
K
E
K
I
S
S
L
L
S
-----
Q
EE-----
E
--
V
L
S
V
E
Q
L
----
G
G
M
T
-
N
Q
N
--
Y
L
A
K
--
T
T
--------
N
--------
K
-
Q
Y
I
V
K
F
-
F
--
G
K
G
T
E
-
K
-
L
I
N
R
-
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
G
-
L
D
-
V
K
N
Y
L
F
D
I
----------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
-
T
L
D
S
T
S
--
I
K
--
T
K
F
-
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
A
K
E
L
R
G
E
F
--
A
----------
P
-
F
-
E
----
E
---
I
K
---
K
-
Y
---
E
------
S
L
-----
I
E
-
E
------
Q
-
I
-----------
P
---
Y
------
A
--------------
N
------
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
L
A
---------------
D
L
-----
G
V
-----
D
--------------
R
--
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
--
Q
---
G
------
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
--
A
A
-
L
F
L
E
-------
S
E
F
----------------------------------
T
-
S
Q
E
-
E
E
T
-
F
L
S
H
Y
E
-----
S
--
D
-
Q
T
P
-------------
V
-------
S
H
E
K
-
I
A
I
-
Y
K
I
L
Q
D
T
-
I
W
S
L
W
T
-----
V
Y
-
K
E
-----------------------------------------------------------
43
HHSearch
55.62
15%
-17
- C3 -
-
4R7B
-
?
A:
[23-279]
------------------------
K
I
I
K
E
K
I
S
S
L
L
S
-----
Q
EE-----
E
--
V
L
S
V
E
Q
L
----
G
G
M
T
-
N
Q
N
--
Y
L
A
K
--
T
T
--------
N
--------
K
-
Q
Y
I
V
K
F
-
F
--
G
K
G
T
E
-
K
-
L
I
N
R
-
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
G
-
L
D
-
V
K
N
Y
L
F
D
I
----------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
-
T
L
D
S
T
S
--
I
K
--
T
K
F
-
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
A
K
E
L
R
G
E
F
--
A
----------
P
-
F
-
E
----
E
---
I
K
---
K
-
Y
---
E
------
S
L
-----
I
E
-
E
------
Q
-
I
-----------
P
---
Y
------
A
--------------
N
------
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
L
A
---------------
D
L
-----
G
V
-----
D
--------------
R
--
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
--
Q
---
G
------
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
--
A
A
-
L
F
L
E
-------
S
E
F
----------------------------------
T
-
S
Q
E
-
E
E
T
-
F
L
S
H
Y
E
-----
S
--
D
-
Q
T
P
-------------
V
-------
S
H
E
K
-
I
A
I
-
Y
K
I
L
Q
D
T
-
I
W
S
L
W
T
-----
V
Y
-
K
E
-----------------------------------------------------------
57
Fugue
54.73
12%
-55
- C3 -
-
3HAM
3
?
A:
[1-299]
----------------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
-----
Q
-------
I
--
K
I
N
E
L
R
Y
L
---
S
S
-
G
-
D
D
S
--
D
T
F
L
C
-----------
N
--------
E
-
Q
Y
V
V
K
V
-
P
--
K
-
R
D
S
-
V
-
R
I
S
Q
-
K
R
E
F
E
L
Y
R
F
L
E
N
-
C
K
-
L
S
-
Y
Q
I
P
A
V
V
Y
Q
S
D
R
F
N
I
M
K
Y
--
I
K
G
-
E
R
-
I
T
Y
E
Q
Y
H
K
L
-
S
--
E
K
E
-----
K
D
--
A
L
A
-
Y
D
E
A
-
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
--
F
--
S
-------
D
A
L
-
V
----
N
---
K
K
---
D
-
K
---
F
L
-
Q
D
-
K
K
L
-----
L
I
-
S
------
I
-
L
-----------
E
---
K
------
E
------
Q
------
L
L
------
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
-----
N
------
N
--
A
V
-----
L
F
-----
K
--------------
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
-----------
N
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
--
L
C
--
L
L
D
-------
C
S
T
D
D
F
----------------------------
G
K
E
F
-
G
R
K
-
V
L
K
-
Y
Y
Q
H
K
A
-----
P
--
E
V
A
E
R
-------------
K
-----
A
E
L
N
D
V
-
Y
W
S
-
I
D
Q
I
I
Y
G
-
Y
E
R
K
---------------------------
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
--
M
F
I
F
--------------------