@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKS6: (2017-10-29 )
MDGAMQGSYATALLKQQQLPESFQFYFKQKQHLSNTQELHQLHELVRPRLKIAIVTETWPPEINGVALSLLQLCQGLQKQGHKILLVRPEQKAKCHDFLPEQECLVMSQAIPKYPTLQFGWPQYLKVSKAFEKFVPDVVHIVTEGPLGLTAMQAAKAKDIPVSSGFHSPFQDFSRFFDLAFLVKPIQKYLCWFHNNTQVTCVPSKDTEEALRGFGITCPLVVVGRGVDTTRFSPKHRSENLRQQWGVDSDTRVMLYVGRLSPEKEVQLIVESYAAMQNIQQQKTKLVVVGDGPDLARLKALPEAKNVIFTGSLCGHDLAVAYASADVFVFASQVETFGNVVLEAMASGLPVIAYDYACAHQYLIHGVNGWLSPLGHKNHFIQQIYQLPSIQQLREMGIQACHKVQQSGWQLPVQQLEQAFYQVVKELSADFT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60---........70........80......-..90.....-.----------------------.---.-------------------100--........---------110-----.---.---------.-..-..--------120-.-..-......--130-.......140-........-150....--...160......----------.170....-.---.---.--180-------..----......190.......200.......210-.-.----.--------...-.-220.......230..--...-------.------------------.240.....--..250.......260-.-.......270.......-280--.......290--..-----.----.--.-------...300--...----.--.------.-..-310------........320.......330-------.-------.-.....340.......350.......360....---------...370...------------------....380.....-.---.-390..-.....-.400..-...-..410.......420.......430----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDGAMQ
G
S
Y
A
T
A
L
L
K
Q
Q
QL
P
E
S
F
Q
F
Y
F
K
Q
K
Q
HLS
N
T
Q
E
L
H
Q
L
H
E
L
V
RPR
L
K
I
A
I
V
TETWPP---EIN
G
V
A
L
S
L
L
Q
L
C
Q
G
L
Q
KQG
H
K
I
L
L
V-RPEQKA
K
C
H-D----------------------F---L-------------------
P
E
---
Q
E
C
L
V
M
S
Q---------AIP-----K---Y---------P-TL-QF--------G---
W
-
P
Q
-
Y
L
K
V
S
K
--
A
F
E
-
K
F
V
P
D
V
V
H
I
--VTEGPL
G
L
-
T
A
M
QAAK--AKDIPVSSGFH
S
----------
P
F
Q
D
F
S
R
F
-
F
---
D
---
L
--
A
F
--------
L
V
----
K
P
I
Q
K
Y
L
C
WFHNN
T
Q
V
T
C
VPSK
D
T
E
E
A
L
R
-G-F----G--------ITC-P-
L
V
V
VGRGVDTTRFSP--
K
H
R
-------
S
------------------
E
N
L
R
Q
QWGV--DSD
T
R
V
M
L
Y
V
GRL-S-
P
-
E
K
E
V
Q
L
I
V
E
S
Y
A
A
M
Q
N
I
-
Q
Q
Q--K
T
K
L
V
V
VGD---GP-----
D
----
L
--
A
-------
R
L
KA-L--PEA----K--
N
------
V
-
I
F
-TG-------SLCGH
D
L
A
V
A
YAS
A
D
V
F
V
F
A
S
-------
Q
-------
V
-
E
T
F
G
N
V
V
L
E
A
M
ASGL
P
V
I
A
Y
D
Y
A
C
A
H
Q
Y
L
I
HG---------
V
N
G
W
L
SPLG------------------H
K
N
H
F
I
Q
Q
I
Y
QL-P---
S
-
I
-
Q
Q
L
-
R
E
M
G
I
-
Q
A
C
H
K
V
-
Q
Q
S-GWQL
P
V
Q
Q
L
E
Q
A
F
Y
Q
V
V
K
E
LSADFT----
9
PsiBlast_PDB
75.55
24%
-
- C1 -
-
4NC9
-
PIMA_MYCS2
A:
[15-363]
------------------------------------------------------------------
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
---
A
S
P
H
-
V
----------------------
K
---
L
-------------------
P
D
---
Y
-
V
V
S
G
G
K
---------
A
V
--------------------
A
-
R
L
-
R
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
-
L
A
L
Q
A
A
E
--
G
---
P
I
V
A
T
F
H
T
-------------
S
T
T
K
S
-
L
---
T
---
L
--
S
V
--------
F
Q
----
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
R
W
Q
M
E
A
L
G
-
S
-
D
----
A
--------
V
E
I
-
P
------
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------
D
------
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
---
A
A
L
P
K
L
-
V
A
R
F
P
D
V
E
I
L
I
V
G
R
---
G
D
E
----
D
----
E
--
L
-------
R
E
Q
A
-
G
--
D
L
A
----
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
L------
G
-------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
-
D
-
D
Q
L
-
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
-------------
41
HHSearch
73.56
22%
-
- C1 -
-
4NC9
-
PIMA_MYCS2
A:
[-1-368]
------------------------------------------------
A
M
R
I
G
M
V
C
P
Y
S
F
D
---
V
P
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
A
S
P
H
V
K
L
P
D
----------------------
Y
V--
V
-------------------
S
G
G--
K
A
V
------------------------------------
A
-
R
L
-
R
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
--
H
E
P
N
A
P
S
L
--
S
M
L
A
L
Q
--
A
A
E
G
P
I
V
A
T
F
H
T
----------
S
T
T
K
S
L
T
L
----------------------------
S
V
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
R
W
Q
M
-
E
-
A
----
L
--------
G
S
--
D
-
A
V
E
I
P
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------------
D
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
A
A
L
P
K
L
V
A
R
--
F
P
--
D
V
E
I
L
I
V
G
R
---
G
D
-----
E
----
D
----------
E
L
R
E
-
Q
--
A
G
D
LA--
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
-------
L
G------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
D
D
-
Q
L
R
-
A
G
Y
V
A
-
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
--------
65
Fugue
70.93
21%
-27
- C1 -
-
3OKP
1
PIMB_CORGL
A:
[4-381]
------------------------------------------------
S
R
K
T
L
V
V
T
N
D
F
P
P
---
R
I
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
S
I
V
V
F
A
S
T
Q
N
A
E
E
A
H
A
Y
-
D
----------------------
K
---
T
-------------------
L
D
---
Y
E
V
I
R
W
P
R
-------------------------------
S
-
V
M
-
L
P
--------
T
---
P
-
T
T
-
A
H
A
M
A
E
--
I
I
R
-
E
R
E
I
D
N
V
W
F
--
G
A
A
A
P
L
A
L
-
M
A
G
T
A
K
Q
--
A
G
A
S
K
V
I
A
S
T
H
G
----------
H
E
V
G
W
S
M
L
-
P
---
G
---
S
--
R
Q
--------
S
L
----
R
K
I
G
T
E
V
------
D
V
L
T
Y
I
S
Q
Y
T
L
R
R
F
K
S
-
A
-
F
----
G
--------
S
H
P
-
T
-
F
E
H
L
P
S
G
V
D
V
K
R
F
T
P
A
T
P
E
D
-------
K
------------------
S
A
T
R
K
K
L
G
F
--
T
D
T
T
P
V
I
A
C
N
S
R
L
-
V
-
P
-
R
K
G
Q
D
S
L
I
K
A
M
P
Q
V
I
A
A
-
R
P
---
D
A
Q
L
L
I
V
G
S
---
G
R
-----
Y
----
E
--
S
-------
T
L
R
R
-
L
A
T
D
V
S
----
Q
--
N
------
V
-
K
F
-
L
G
-------
R
L
E
Y
Q
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
R
T
R
GGGL
D
-------
V
-
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
S
G
G
A
P
E
T
V
T
P
A
----------
T
G
L
V
V
E
G
S
------------------
D
V
D
K
L
S
E
L
L
I
E
L
L
D
---
D
-
P
-
I
R
R
-
A
A
M
G
A
-
A
G
R
A
H
V
-
E
A
E
W
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
-----------
46
HHSearch
70.44
22%
-48
- C1 -
-
3OKA
2
PIMB_CORGL
A:
[4-380]
------------------------------------------------
S
R
K
T
L
V
V
T
N
D
F
P
P
---
R
I
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
S
--
I
V
V
F
-
A
S
T
Q
N
A
E
E
A
-
H
----------------------
A
---
Y
-------------------
D
----
K
T
L
D
Y
E
V
I
---------
R
W
P
-----
R
---
S
-----------
V
M
-
L
P
--------
T
---
P
-
T
T
-
A
H
A
M
A
E
--
I
I
R
-
E
R
E
I
D
N
V
W
F
--
G
A
A
A
P
L
A
L
-
M
A
G
T
A
K
Q
--
A
G
A
S
K
V
I
A
S
T
H
G
----------
H
E
V
G
W
S
M
------------------------
L
----
P
G
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
S
Q
Y
T
L
R
R
F
K
-
S
A
F
----
G
--------
S
H
P
-
T
-
F
E
H
L
P
S
G
V
D
V
K
R
F
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--
A
T
P
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D
-----
K
------------------
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A
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K
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D
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A
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D
A
Q
L
L
I
V
G
S
---
G
R
-----
Y
----
E
--
S
-------
T
L
R
R
-
L
--
A
T
D
VS--
Q
--
N
------
V
-
K
F
-
L
G
-------
R
L
E
Y
Q
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
-------
R
T
R
GGGLD
V
-
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
S
G
G
A
P
E
T
V
T
P
----------
A
T
G
L
V
V
E
G
S
------------------
D
V
D
K
L
S
E
L
L
I
E
L
-
L
---
D
D
P
-
I
R
R
-
A
A
M
G
A
-
A
G
R
A
H
V
E
A
E
W
-
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
------------
44
HHSearch
69.98
22%
-51
- C1 -
-
3OKP
1
PIMB_CORGL
A:
[4-381]
------------------------------------------------
S
R
K
T
L
V
V
T
N
D
F
P
P
---
R
I
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
--
S
I
V
V
F
-
A
S
T
Q
N
A
E
E
A
-
H
----------------------
A
---
Y
-------------------
D
K
----
T
L
D
Y
E
V
I
---------
R
W
P
-----
R
---
S
-----------
V
M
-
L
P
--------
T
---
P
-
T
T
-
A
H
A
M
A
E
--
I
I
R
-
E
R
E
I
D
N
V
W
F
--
G
A
A
A
P
L
A
L
-
M
A
G
T
A
K
Q
--
A
G
A
S
K
V
I
A
S
T
H
G
----------
H
E
V
G
W
S
M
L
----------------------------
P
G
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
S
Q
Y
T
L
R
R
F
K
-
S
A
F
----
G
--------
S
H
P
-
T
-
F
E
H
L
P
S
G
V
D
V
K
R
F
T
P
--
A
T
P
E
D
-----
K
------------------
S
A
T
R
K
K
L
G
F
--
T
D
T
T
P
V
I
A
C
N
S
R
L
-
V
-
P
-
R
K
G
Q
D
S
L
I
K
A
M
P
Q
V
I
A
A
--
R
P
--
D
A
Q
L
L
I
V
G
S
---
G
R
-----
Y
----
E
--
S
-------
T
L
R
R
-
L
--
A
T
D
----
V
SQ
N
------
V
-
K
F
-
L
G
-------
R
L
E
Y
Q
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
-------
R
T
R
GGGLD
V
-
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
S
G
G
A
P
E
T
V
T
P
----------
A
T
G
L
V
V
E
G
S
------------------
D
V
D
K
L
S
E
L
L
I
E
L
-
L
---
D
D
P
-
I
R
R
-
A
A
M
G
A
-
A
G
R
A
H
V
E
A
E
W
-
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
-----------
2
PsiBlast_PDB
68.76
23%
-1
- C1 -
-
3MBO
6
BSHA_BACAN
A:
[35-408]
------------------------------------------------
K
L
K
I
G
I
---
T
C
Y
P
---
S
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
-
T
S
G
L
P
F
---------------------------
V
---
Y
-------------------
P
N
I
Y
F
H
E
V
T
V
N
Q
Y
---------
S
V
F
-----
Q
---
Y
---------
P
-
P
Y
-
D
L
--------
A
---
L
-
A
S
---
K
M
A
E
--
V
A
Q
-
R
E
N
L
D
I
L
H
V
--
H
Y
A
I
P
H
A
I
-
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
TDITVLGSDP
S
L
N
N
L
I
R
F
G
I
---
E
---
Q
--
S
D
--------
V
V
----
T
A
V
S
H
S
L
I
---
N
E
T
H
E
L
V
K
P
N
K
D
I
Q
-----------------------------
T
V
Y
N
F
I
D
E
-
R
V
Y
F
--
K
R
D
-------
M
------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
--
V
-
T
E
V
--
D
A
K
L
L
L
V
G
D
---
G
P
-----
E
F
C
T
I
L
--
Q
-------
L
V
K
N
-
L
--
H
I
E
----
D
--
R
------
V
-
L
F
-
L
G
-------
K
--
Q
D
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
------------------
D
T
T
G
V
A
D
Q
A
I
Q
L
-
L
---
K
-
D
-
E
E
L
H
R
N
M
G
E
-
R
A
R
E
S
V
Y
E
Q
F
-
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
L
R
D
----------
63
Fugue
68.10
21%
-80
- C1 -
-
2GEK
1
PIMA_MYCS2
A:
[21-393]
-------------------------------------------------
M
R
I
G
M
V
C
P
Y
S
F
D
---
V
P
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
A
S
P
H
V
K
L
-
P
----------------------------------------------------------
D
---------
Y
V
V
-----
S
---
G
---------
G
-
K
A
-
V
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
--
H
E
P
N
A
P
S
--
L
S
M
L
A
L
Q
--
A
A
E
G
P
I
V
A
T
F
H
T
----------
S
T
T
K
S
L
T
L
-
S
---
V
---
F
--
Q
-------------------
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
R
W
Q
M
-
E
-
A
----
L
--------
G
S
--
D
-
A
V
E
I
P
N
G
V
D
V
A
S
F
A
D
---------------------------------
A
P
L
L
D
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
D
E
-
P
-
R
K
G
M
A
V
L
L
A
A
L
P
K
L
V
A
--
R
F
P
--
D
V
E
I
L
I
V
G
R
---
G
D
-----
E
----
D
--
E
-------
L
R
E
Q
A
G
--
D
L
A
----
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
-------
L
G------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
E
--
D
-
D
-
Q
L
R
-
A
G
Y
V
A
-
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
K
V
Q
V
S---
45
HHSearch
65.49
19%
-8
- C1 -
-
3C48
-
MSHA_CORGL
B:
[21-431]
-------------------------------------------------
M
R
V
A
M
I
S
M
H
T
S
P
LQQ---
G
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
G
I
E
V
D
I
Y
-
T
R
A
T
R
P
S
Q
G
-
E
----------------------
I
VRV
A
-------------------
E
N
L
--
R
V
I
N
I
A
A
G
---------
P
Y
E
-----
G
L--
S
---------
K
E
E
L
-
P
T
--------
Q
---
L
-
A
A
F
T
G
G
M
L
S
F
T
R
R
E
-
K
V
T
Y
D
L
I
H
S
--
H
Y
W
L
S
G
Q
--
V
G
W
L
L
R
D
--
L
W
R
I
P
L
I
H
T
A
H
T
----------
L
A
A
V
K
---------------
T
P
--------
E
S
----
E
A
R
R
I
C
E
Q
Q
L
V
D
N
A
D
V
L
A
V
N
T
Q
E
E
M
Q
D
L
M
-
H
H
Y
----
D
--------
A
D
P
D
R
-
I
S
V
V
S
P
G
A
D
V
E
L
Y
S
P
--
G
N
D
R
A
-----
T
------------------
E
R
S
R
R
E
L
G
I
--
P
L
H
T
K
V
V
A
F
V
G
R
L
-
Q
-
P
-
F
K
G
P
Q
V
L
I
K
A
V
A
A
L
F
D
R
--
D
P
DR
N
L
R
V
I
I
C
G
G
---
P
S
---------------------
T
Y
R
H
-
M
--
A
E
E
L
GVE
K
--
R
------
I
-
R
F
-
L
D
-------
P
R
P
P
S
E
L
V
A
V
Y
R
A
A
D
I
V
A
V
P
S
-------
F
-------
N
-
E
S
F
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
A
R
V
G
G
L
P
I
A
V
A
E
G
---------
E
T
G
L
L
V
D
G
H
------------------
S
P
H
A
W
A
D
A
L
A
T
L
-
L
---
D
D
D
-
E
T
R
-
I
R
M
G
E
-
D
A
V
E
H
A
-
R
T
F
-
S
W
A
A
T
A
A
Q
L
S
S
L
Y
N
D
A
I
A
N
E
N
V
-------
1
PsiBlast_PDB
64.94
23%
-12
- C1 -
-
2JJM
-
BSHA_BACAN
A:
[2-373]
------------------------------------------------
K
L
K
I
G
I
---
T
C
Y
P
-----
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
-
T
S
G
L
P
-----
K
----------------------
V
---
Y
-------------------
P
N
I
Y
F
H
E
V
T
V
N
-------------
F
-----
Q
---
Y
---------
P
-
P
Y
-
D
L
--------
A
---
L
-
A
S
---
K
M
A
E
--
V
A
Q
-
R
E
N
L
D
I
L
H
V
--
H
Y
A
I
P
H
A
I
-
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
TDITVLGSDP
S
L
N
N
L
I
R
F
G
I
---
E
---
Q
--
S
D
--------
V
V
----
T
A
V
S
H
S
L
I
---
N
E
T
H
E
L
V
K
P
N
K
D
I
Q
-----------------------------
T
V
Y
N
F
I
D
E
-
R
V
Y
F
--
K
R
D
-------
M
------------------
T
Q
L
K
K
E
Y
G
I
--
S
---
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
--
V
-
T
E
V
--
D
A
K
L
L
L
V
G
D
---
G
P
-----
E
F
C
T
I
L
--
Q
-------
L
V
K
N
-
L
--
H
I
E
----
D
--
R
------
V
-
L
F
-
L
G
-------
K
--
Q
D
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
------------------
D
T
T
G
V
A
D
Q
A
I
Q
L
-
L
---
K
-
D
-
E
E
L
H
R
N
M
G
E
-
R
A
R
E
S
V
Y
E
Q
F
-
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
L
------------
71
Fugue
64.35
21%
-62
- C1 -
-
4XSO
2
?
A:
[7-384]
-------------------------------------------------
M
K
I
L
F
L
D
Q
S
--
G
---
K
P
G
G
A
E
L
C
L
I
D
I
A
K
P
Y
R
D
R
A
L
V
G
L
F
-----
A
D
G
A
F
K
-
T
----------------------
L
---
L
-------------------
E
Q
---
H
H
I
P
V
E
V
-----------
F
T
-----
N
---
Q
---------
P
-
S
L
-
G
Q
--------
L
---
A
-
P
L
-
V
A
K
V
V
Q
--
T
A
H
-
E
Y
--
D
L
I
Y
A
--
N
T
Q
K
A
L
V
V
-
G
A
I
A
S
F
I
--
A
R
R
-
P
L
V
Y
H
L
H
D
----------
I
L
S
P
E
H
---------------
F
--------
S
Q
----
T
N
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
S
Q
A
S
Q
T
A
F
I
-
Q
-
A
----
G
G-------
R
A
E
-
L
-
T
K
V
I
Y
N
G
F
D
I
N
L
Y
K
T
S-
P
S
D
-------
I
------------------
S
K
L
R
Q
Q
L
G
V
--
A
N
N
F
V
V
G
H
F
-
S
R
L
-
S
-
P
-
W
K
G
Q
H
I
L
I
D
A
L
A
Q
C
P
-----
P
--
Q
V
T
A
I
L
V
G
D
ALF
G
E
-----
Q
----
D
--
Y
-------
V
K
E
L
-
H
--
Q
Q
I
----
T
--
R
L
GLENR
V
-
K
F
-
L
G
-------
F
--
R
A
D
I
P
Q
L
M
A
A
C
D
L
V
A
H
T
S
-------
T
-------
A
P
E
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
A
A
K
A
G
G
A
M
E
L
V
E
H
G
---------
V
N
G
F
L
T
T
P
G
------------------
E
S
Q
E
L
A
N
I
I
N
T
C
-
I
---
E
-
D
-
T
Q
K
-
T
A
T
I
A
-
S
N
A
Q
A
I
-
A
S
Q
-
R
F
--
D
V
V
T
I
N
Q
Q
I
A
E
T
L
S
S
L
---------
64
Fugue
63.89
20%
-16
- C1 -
-
3C48
-
MSHA_CORGL
A:
[19-438]
-----------------------------------------------
S
H
M
R
V
A
M
I
S
M
H
T
S
P
---
L
Q
Q
G
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
G
I
E
V
D
I
Y
-
T
R
A
T
R
P
S
Q
G
-
E
----------------------
I
---
V
-------------------
R
V
---
A
E
N
L
R
V
I
N
I
A
A
G
PYEGL
S
K
E
-----
E
---
L
---------
P
-
T
Q
-
L
A
--------
A
---
F
-
T
G
-
G
M
L
S
F
T
--
R
R
E
-
K
V
T
Y
D
L
I
H
S
--
H
Y
-
W
L
S
G
Q
-
V
G
W
L
L
R
D
--
L
W
R
I
P
L
I
H
T
A
H
T
L---------
A
A
V
K
N
S
Y
D
-
T
---
P
---
E
--
S
E
--------
A
R
----
R
I
C
E
Q
Q
L
V
D
N
A
D
--
V
L
A
V
N
T
Q
E
E
M
Q
D
L
M
H
-
H
-
Y
----
D
--------
A
D
P
-
D
R
I
S
V
V
S
P
G
A
D
V
E
L
Y
S
P
--
G
---------
T
------------------
E
R
S
R
R
E
L
G
I
--
P
L
H
T
K
V
V
A
F
V
G
R
L
-
Q
-
P
-
F
K
G
P
Q
V
L
I
K
A
V
A
A
L
F
D
R
-
D
P
---
D
R
N
L
R
V
I
I
C
---
G
G
-----
P
----
S
--
D
-------
T
Y
R
H
-
M
--
A
E
E
----
L
--
G
VEKR--
I
-
R
F
-
L
D
-------
P
R
P
P
S
E
L
V
A
V
Y
R
A
A
D
I
V
A
V
P
S
-------
F
-------
N
-
E
S
F
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
A
R
V
G
G
L
P
I
A
V
A
E
G
---------
E
T
G
L
L
V
D
G
H
------------------
S
P
H
A
W
A
D
A
L
A
T
L
-
L
D
--
D
-
D
-
E
T
R
-
I
R
M
G
E
-
D
A
V
E
H
A
-
R
T
F
-
S
W
A
A
T
A
A
Q
L
S
S
L
Y
N
D
A
I
A
N
E
N
V
D
G
E
THHG
60
HHSearch
63.41
18%
6
- C1 -
-
3FRO
2
?
A:
[1-435]
-----------------------------------------------
R
H
M
K
V
L
L
L
G
F
E
F
L
P
V--
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
-
T
P
S
H
G
R
F
Q
G
-
E
----------------------
E
---
I
G
K
I
R
V
FG
E
E
V
Q
V
K
V
S
Y
E
E
R
G
N
L
--
R
I
Y
R
I
G
G
G
---------
L
L
D
-----
S
EDV
Y
G--------
P
-
G
W
-
D
G
L
I
R
K
A
V
T
F
G
---
R
-
A
S
-
V
L
L
L
N
D
--
L
L
R
E
E
P
L
P
D
V
V
H
F
--
H
D
W
H
T
V
F
--
A
G
A
L
I
K
K
--
Y
F
K
I
P
A
V
F
T
I
H
R
----------
L
N
K
S
K
L
P
A
-
F
---
Y
---
F
H
E
A
G
--------
L
S
ELAP
Y
P
D
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
S
R
G
Y
L
I
D
E
W
G
F
-
F
----
R
--------
N
F
E
G
K
-
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
E
--
S
Y
L
TGS
R
D
E
R
K
------------------
K
S
L
L
S
K
F
G
---
M
D
E
G
V
T
F
M
F
I
G
R
F
-
D
-
R
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
K
K
E
F
Q
--
E
M
R
F
I
I
I
G
K
---
G
D
-----
P
----
E
L
E
G
-------
W
A
R
S
-
L
--
E
E
K
H
---
G
--
N
------
V
-
K
V
I
T
E
-------
M
L
S
R
E
F
V
R
E
L
Y
G
S
V
D
F
V
I
I
P
S
-------
Y
-------
F
-
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
N
----------
E
T
G
I
L
V
K
A
G
------------------
D
P
G
E
L
A
N
A
I
L
K
A
-
L
---
E
L
S
R
S
D
L
-
S
K
F
R
E
-
N
C
K
K
R
A
-
M
S
F
-
S
W
E
K
S
A
E
R
Y
V
K
A
Y
T
G
S
I
D
R
A
F
--------
40
HHSearch
62.26
22%
-25
- C1 -
-
4N9W
2
PIMA_MYCS2
A:
[4-372]
------------------------------------------------
A
M
R
I
G
M
V
C
P
Y
S
F
D
---
V
P
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
A
S
P
H
V
K
L
P
D
----------------------
Y
V--
V
-------------------
S
G
G
--
K
A
V
P
I
P
Y
N
---------
G
-------
S
---
V
---------
A
-
R
L
-
R
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
--
H
E
P
N
A
P
S
L
--
S
M
L
A
L
Q
--
A
A
E
G
P
I
V
A
T
F
H
T
----------
S
T
T
K
S
L
T
L
----------------------------
S
V
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
-------------------------------
A
V
E
I
P
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------------
D
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
A
A
L
P
K
L
V
A
R
--
F
P
--
D
V
E
I
L
I
V
G
R
---
G
D
-----
E
----
D
----------
E
L
R
E
-
Q
--
A
G
D
LA--
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
-------
L
G------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
D
D
-
Q
L
R
-
A
G
Y
V
A
-
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
--------
7
PsiBlast_PDB
61.57
24%
-24
- C1 -
-
2GEK
1
PIMA_MYCS2
A:
[35-383]
------------------------------------------------------------------
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
---
A
S
P
H
-
V
----------------------
K
---
L
-------------------
P
D
---
Y
-
V
V
S
G
G
K
---------
A
V
--------------------------
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
-
L
A
L
Q
A
A
E
--
G
---
P
I
V
A
T
F
H
T
-------------
S
T
T
K
S
-
L
---
T
---
L
--
S
V
--------
F
Q
----
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
R
W
Q
M
E
A
L
G
-
S
-
D
----
A
--------
V
E
I
-
P
------
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------
D
------
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
---
A
A
L
P
K
L
-
V
A
R
FP
D
V
E
I
L
I
V
G
R
---
G
D
E
----
D
----
E
--
L
-------
R
E
Q
A
-
G
--
D
L
A
----
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
L------
G
-------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
-
D
-
D
Q
L
-
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
-------------
6
PsiBlast_PDB
61.34
24%
-23
- C1 -
-
2GEJ
1
PIMA_MYCS2
A:
[35-383]
------------------------------------------------------------------
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
---
A
S
P
H
-
V
----------------------
K
---
L
-------------------
P
D
---
Y
-
V
V
S
G
G
K
---------
A
V
--------------------------
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
-
L
A
L
Q
A
A
E
--
G
---
P
I
V
A
T
F
H
T
-------------
S
T
T
K
S
-
L
---
T
---
L
--
S
V
--------
F
Q
----
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
R
W
Q
M
E
A
L
G
-
S
-
D
----
A
--------
V
E
I
-
P
------
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------
D
------
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
---
A
A
L
P
K
L
-
V
A
R
FP
D
V
E
I
L
I
V
G
R
---
G
D
E
----
D
----
E
--
L
-------
R
E
Q
A
-
G
--
D
L
A
----
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
L------
G
-------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
-
D
-
D
Q
L
-
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
-------------
8
PsiBlast_PDB
61.08
24%
-23
- C1 -
-
4N9W
2
PIMA_MYCS2
A:
[19-367]
------------------------------------------------------------------
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
-
A
P
---
A
S
P
H
-
V
----------------------
K
---
L
-------------------
P
D
---
Y
-
V
V
S
G
G
K
---------
A
V
P
IPYNG
S
---
V
---------
A
-
R
L
-
R
F
--------
G
---
P
-
A
T
-
H
R
K
V
K
K
--
W
I
A
-
E
G
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
-
L
A
L
Q
A
A
E
--
G
---
P
I
V
A
T
F
H
T
-------------
S
T
T
K
S
-
L
---
T
---
L
--
S
V
--------
F
Q
----
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
--------------------
A
--------
V
E
I
-
P
------
N
G
V
D
V
A
S
F
A
D
--
A
P
L
-------
L
------------------
D
------
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
---
A
A
L
P
K
L
-
V
A
R
F
P
D
V
E
I
L
I
V
G
R
---
G
D
E
----
D
----
E
--
L
-------
R
E
Q
A
-
G
--
D
L
A
----
G
--
H
------
L
-
R
F
-
L
G
-------
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
L------
G
-------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
------------------
D
A
D
G
M
A
A
A
L
I
G
I
-
L
---
E
-
D
-
D
Q
L
-
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
-
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
-------------
47
HHSearch
58.49
21%
-14
- C1 -
-
2JJM
-
BSHA_BACAN
I:
[9-373]
----------------------------------------------------------
C
Y
P
-----
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
-
T
S
G
L
P
-----
K
----------------------
V
---
Y
-------------------
P
N
I--
Y
F
H
E
V
T
V
N
---------------------
F
---------
Q
-
Y
P
-
P
Y
--------
D
---
L
-
A
L
-
A
S
K
M
A
E
--
V
A
Q
-
R
E
N
L
D
I
L
H
V
--
H
Y
A
I
P
H
A
I
-
C
A
Y
L
A
K
Q
MI
G
E
R
I
K
I
V
T
T
L
H
G
----------
T
D
I
T
V
L
G
S
-----------------------
D
----
P
S
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
S
H
S
L
I
N
E
T
H
-
E
-
L
----
V
--------
K
P
N
K
D
-
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
K
--
R
D
M
--------------------------
T
Q
L
K
K
E
Y
G
I
--
S
---
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
E
---
V
--
D
A
K
L
L
L
V
G
D
---
G
P
-----
E
----
F
--
C
-------
T
I
L
Q
-
L
--
V
K
N
LHIE
D
--
R
------
V
-
L
F
-
L
G
-------
K
Q
--
D
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
------------------
D
T
T
G
V
A
D
Q
A
I
Q
L
-
L
---
K
D
E
-
E
L
H
-
R
N
M
G
E
-
R
A
R
E
S
V
Y
E
Q
F
-
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
L
------------
62
HHSearch
57.08
20%
-26
- C1 -
-
4XSO
2
?
B:
[7-384]
-------------------------------------------------
M
K
I
L
F
L
D
Q
S
--
G
---
K
P
G
G
A
E
L
C
L
I
D
I
A
K
P
Y
R
D
-
R
A
L
V
G
L
F
-
A
D
G
A
F
K
T
L
L
-
E
--------------------------
Q
-------------------
H
H
I--
P
V
E
V
F
T
N
Q
---------
P
------------------------------------
S
---
L
G
Q
L
-
A
P
L
V
A
K
--
V
V
Q
T
A
H
E
Y
D
L
I
Y
A
--
N
T
Q
K
A
L
V
--
V
G
A
I
A
S
F
--
I
A
R
R
P
L
V
Y
H
L
H
D
----------
I
L
S
P
E
H
F
S
-----------------------
Q
----
T
N
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
S
Q
A
S
Q
T
A
F
I
-
Q
-
A
----
G
--------
G
R
A
E
L
-
T
K
V
I
Y
N
G
F
D
I
N
L
Y
K
T
--
S
P
S
D------
I
------------------
S
K
L
R
Q
Q
L
G
V
---
A
N
N
F
V
V
G
H
F
S
R
L
-
S
-
P
-
W
K
G
Q
H
I
L
I
D
A
L
A
Q
C
P
-----
P
--
Q
V
T
A
I
L
V
G
D
---
A
L
FGEQD
Y
----
V
--
K
-------
E
L
H
Q
-
Q
--
I
T
R
LGLE
N
--
R
------
V
-
K
F
-
L
G
-------
F
R
--
A
D
I
P
Q
L
M
A
A
C
D
L
V
A
H
T
S
-------
T
A------
P
-
E
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
A
A
K
A
G
G
A
M
E
L
V
E
H
G
---------
V
N
G
F
L
T
T
P
G
------------------
E
S
Q
E
L
A
N
I
I
N
T
C
-
I
---
E
D
T
-
Q
K
T
-
A
T
I
A
S
-
N
A
Q
A
I
A
S
Q
R
F
-
D
V
V
T
I
N
Q
Q
I
A
E
T
L
S
S
L
-------------
54
HHSearch
56.34
17%
-18
- C1 -
-
2QZS
3
GLGA_ECOLI
A:
[1-477]
-------------------------------------------------
M
Q
V
L
H
V
C
S
E
M
F
P
LL-
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
-
L
P
A
F
P
D
I
R
R
-
G
V
TDAQVV
S
R
R
D
T
FA
G
H
I
T
L
L
F
G
H
---
Y
-------------------
N
G
V
--
G
I
Y
L
I
D
A
P
---------
H
L
Y
DRPGS
P
---
Y
HDTNLFAYT
D
-
N
V
L
R
F
--------
A
L
L
G
W
-
V
G
-
A
E
M
A
S
G
--
L
D
P
-
F
W
R
P
D
V
V
H
A
--
H
D
W
H
A
G
L
A
-
P
A
Y
L
A
A
R
--
G
R
P
A
K
S
V
F
T
V
H
N
----------
L
A
Y
Q
G
M
F
Y
-
A
HHM
N
DIQ
L
--
P
W
SFFNIHGL
E
F
----
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
-
E
-
P
QFAY
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
-
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
--
E
T
D
-------
L
LLA
S
R
Y
T
RDTLEDK
A
E
N
K
R
Q
L
Q
I
A
M
G
L
KV
D
D
K
V
P
L
F
A
V
V
S
R
L
-
T
-
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
Q
------
G
G
Q
L
A
L
L
G
A
---
G
D
-----
P
V
L
--
Q
--
E
-------
G
F
L
A
-
A
--
A
A
E
----
Y
PG
Q
------
V
G
V
Q
-
I
G
-------
Y
H
-
E
A
F
S
H
R
I
M
G
G
A
D
V
I
L
V
P
S
-------
R
-------
F
-
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
D
C
S
L
E
N
L
A
D
GV
A
S
G
F
V
F
E
D
S
------------------
N
A
W
S
L
L
R
A
I
R
R
A
-
F
V
L
W
S
R
P
-
S
L
W
-
R
F
V
Q
R
-
Q
A
--
M
A
-
M
D
F
-
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
------------
49
HHSearch
56.17
15%
-
- C1 -
-
3OY2
-
?
A:
[1-392]
-------------------------------------------------
M
K
L
I
I
V
G
A
H
S
-
S
---
V
P
S
G
Y
G
R
V
M
R
A
I
V
P
R
I
S
K
-
A
H
E
V
I
V
F
-
G
I
H
A
F
G
R
S
V
-
H
----------------------------------------------
A
----
N
I
E
E
F
D
A
Q
---------
T
A
E
-----
H
---
V
---------
R
-
G
L
-
N
E
--------
Q
---
G
-
F
Y
-
Y
S
G
L
S
E
--
F
I
D
-
V
H
K
P
D
I
V
M
I
--
Y
N
D
P
I
V
I
G
N
Y
L
L
A
M
G
K
C-
S
H
R
T
K
I
V
L
Y
V
D
L
----------
V
S
K
N
I
R
E
------------------------------
N
L
W
W
--
I
F
S
H
P
K
V
V
G
V
M
A
M
S
K
C
W
I
S
D
I
C
-
N
-
Y
----
G
--------
C
K
V
-
P
-
I
N
I
V
S
H
F
V
D
T
K
T
I
Y
D
--
A
R
K
-------
L
------------------
V
----
G
L
S
E
--
Y
N
D
D
V
L
F
L
N
M
N
R
N
-
T
-
A
-
R
K
R
L
D
I
Y
V
L
A
A
A
R
F
I
S
K
--
Y
P
--
D
A
K
V
R
F
L
C
N
---
S
H
-----
H
----
E
--
S
KFD
L
H
S
I
A
L
R
E
-
L
--
V
A
S
GVD-
N
--
V
------
F
-
T
H
-
L
N
K
IMINR
T
V
L
T
D
E
R
V
D
M
M
Y
N
A
C
D
V
I
V
N
C
S
-------
S
-------
G
-
E
G
F
G
L
C
S
A
E
G
A
V
L
G
K
P
L
I
I
S
A
V
G
G
A
D
D
Y
F
S
-
G
---------
D
C
V
Y
K
I
K
P
S
A
W
I
S
VDDRDGI
G
G
I
E
G
I
I
D
V
D
D
L
V
E
A
F
T
F
F
-----
K
D
E
-
K
N
R
-
K
E
Y
G
K
-
R
V
Q
D
F
V
K
T
K
P
-
T
W
D
D
I
S
S
D
I
I
D
F
F
N
S
L
L
R
-----------