@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLH2: (2017-11-02 )
MHIAALHQPSQVQLNQDGNLKHFLTIEGLSKENLTKILDTAQSFLDDNNNLINRPLLEGRTVMNLFFENSTRTRTTFEAAAKRLSANVLNIDIARSSTSKGETLRDTLWNLEAMAADIFVVRHSSSGAAHFIAKDVCPKVAIINAGDGRHAHPTQAMLDMLTIRREMKKPFEDLSVAIIGDIKHSRVARSDVAALQTLGCKDIRVIAPNTLLPVGFSEYGDHVRLFNNMDEGITGCDVIIALRIQNERIDSPALSSQSEFYRMYGLNKERLSLAKPDCIVMHPGPMNRGVEIDSSIADGEQSVILKQVTNGIAVRMAVLALSMQGQLQEQGLIDAIAL
Atome Classification :
(74 SA)
.........10........20........30........40........50........60......-..70........80........90-.......-.100.......110.......120....-...130.......140.........150.......160.......170.......180.......190.......200.......210..----...-----..----.----220.....---..230.......240.......250.......260.---..---....270.......280.......290.......300.......310.......320.......330......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
H
I
AALHQP
S
Q
V
Q
LNQDGN
L
K
H
F
L
T
IEGL
S
K
E
N
L
T
K
I
L
D
T
A
Q
S
F
LDDNNNLINRPLLEG
R
T
V
M
N
L
F
F-ENSTRT
R
T
T
F
E
A
A
A
K
R
LSA
N
V
L
N
I
-
D
I
ARSST-SKG
E
T
L
R
D
T
L
W
N
L
E
A
M
A
A
D
I
F
V
V
R
HSSS-GA
A
H
F
I
A
K
DVCP
K
V
--
A
I
I
NAGDGRHAH
P
T
Q
A
M
L
D
M
L
T
I
R
R
E
M
KK
P
F
E
DL
S
V
A
I
I
GDI
K
H
S
R
V
A
R
S
D
V
A
A
L
Q
TLGCK
D
I
R
V
IAPN
T
L
-LP----V
G
F
-----
S
E----Y----G
D
H
V
R
L
FN---NMDEGITG
C
D
V
I
I
A
L
R
I
QNERIDSPALS
S
Q
S
E
F
Y
R
M
---YG---L
N
K
E
R
LSLAKP
D
C
I
V
MHPGPMNRG
V
E
IDSSIAD
G
E
Q
S
V
I
L
K
Q
VTN
G
I
A
V
R
M
A
V
L
A
L
S
M
QG
Q
L
Q
EQGLIDAIAL
149
HHSearch
96.95
43%
-107
- C7 -
-
3R7F
1
PYRB_BACSU
A:
[1-291]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
----
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
--
Y
Y
E
E
L
V
S
Q
V
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
-
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
-
R
V
L
F
S
G
P
S
E
W
-
Q
D
----
E
E
N
------------------
T
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
3
PsiBlast_PDB
93.02
43%
-64
- C7 -
-
3R7F
1
PYRB_BACSU
A:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
27
PsiBlast_CBE
92.37
43%
-66
- C7 -
-
3R7F
3
PYRB_BACSU
B:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
26
PsiBlast_CBE
91.38
43%
-64
- C7 -
-
3R7F
1
PYRB_BACSU
C:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
2
PsiBlast_PDB
91.02
43%
-68
- C7 -
-
3R7D
-
PYRB_BACSU
A:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
25
PsiBlast_CBE
90.23
43%
-58
- C7 -
-
3R7L
2
PYRB_BACSU
B:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
24
PsiBlast_CBE
90.11
43%
-55
- C7 -
-
3R7L
2
PYRB_BACSU
C:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
21
PsiBlast_CBE
89.96
43%
-56
- C7 -
-
3R7L
2
PYRB_BACSU
F:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
4
PsiBlast_PDB
89.95
43%
-59
- C7 -
-
3R7L
2
PYRB_BACSU
A:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
23
PsiBlast_CBE
89.67
43%
-60
- C7 -
-
3R7L
2
PYRB_BACSU
D:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
22
PsiBlast_CBE
89.48
43%
-55
- C7 -
-
3R7L
2
PYRB_BACSU
E:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
TYV
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
1
PsiBlast_PDB
84.67
43%
-
- C7 -
-
2AT2
-
PYRB_BACSU
A:
[1-290]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
----
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
Y
E
E
L
V
S
Q
V
--
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
R
---------
V
-
L
F
----
S
G
P
-----
S
E
----
W
----
Q
D
E
E
N
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
--------------
148
HHSearch
83.58
43%
-
- C7 -
-
2AT2
-
PYRB_BACSU
C:
[1-293]
-------------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
----
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
--
Y
Y
E
E
L
V
S
Q
V
N
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
-
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
-
R
V
L
F
S
G
P
S
E
W
-
Q
D
----
E
E
N
------------------
T
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
S
Q
E
G
Y
L
N
K
---
Y
G
---
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
T
N
V
-----------
12
PsiBlast_PDB
81.75
32%
-78
- C7 -
-
5G1O
2
PYR1_HUMAN
A:
[13-308]
--------------------
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
E
A
-------
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
L
A
A
K
H
-
C
-
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
-
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
-
L
A
C
L
L
T
Q
Y
R
V
S
L
R
Y
V
A
P
P
S
L
R
M
P
----
P
T
V
-----
R
A
----
F
V
A
S
R
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
-----
F
------------
F
G
QFI
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
------------------
52
PsiBlast_CBE
81.25
32%
-77
- C7 -
-
5G1O
2
PYR1_HUMAN
C:
[13-308]
--------------------
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
----------
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
L
A
A
K
H
-
C
-
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
-
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
-
L
A
C
L
L
T
Q
Y
R
V
S
L
R
Y
V
A
P
P
S
L
R
M
P
----
P
T
V
-----
R
A
----
F
V
A
S
R
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
-----
F
------------
F
G
QFI
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
------------------
151
HHSearch
80.45
30%
-72
- C7 -
-
5G1O
3
F:
[5-313]
------------
P
L
L
H
S
L
V
G
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
-----------
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
--
A
V
E
L
A
A
K
H
C
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
-
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
R
V
-
S
L
R
Y
V
A
P
P
S
L
R
M
P
----
P
T
V
-----
R
A
F
V
A
S
R
----
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
G
S
T
--
Q
E
Y
E
A
C
F
G
Q
---
F
I
---
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
R
V
--
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
G
R
-------------
48
PsiBlast_CBE
80.39
32%
-85
- C7 -
-
5G1P
2
PYR1_HUMAN
C:
[13-308]
--------------------
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
E
A
T
S
S
V
-
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
L
A
A
K
H
-
C
-
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
-
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
-
L
A
C
L
L
T
Q
Y
R
V
S
L
R
Y
V
A
P
P
------------------
A
----
F
VASR
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
--------------
C
---
F
G
Q
F
I
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
------------------
150
HHSearch
80.35
30%
-69
- C7 -
-
5G1N
2
PYR1_HUMAN
E:
[8-313]
---------------
H
S
L
V
G
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
E
A
T
S
S
V
-
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
--
A
V
E
L
A
A
K
H
C
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
-
L
G
T
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Y
R
V
-
S
L
R
Y
V
A
P
P
S
L
R
M
P
----
P
T
V
-----
R
A
FVAS
R
----
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
F
G
S
T
--
Q
E
Y
E
A
C
F
G
Q
---
F
I
---
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
R
V
--
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
T
V
L
G
R
-------------
46
PsiBlast_CBE
80.26
32%
-87
- C7 -
-
5G1P
2
PYR1_HUMAN
E:
[13-308]
--------------------
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
E
A
T
S
S
V
-
Q
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
L
A
A
K
H
-
C
-
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
-
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
-
L
A
C
L
L
T
Q
Y
R
V
S
L
R
Y
V
A
P
P
S
--
M
P
----
P
T
V
-----
R
A
----
F
VA
S
R
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
-----
F
G
----
Y
E
A
C
---
F
G
Q
FI
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
--
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
------------------
51
PsiBlast_CBE
80.24
32%
-75
- C7 -
-
5G1O
2
PYR1_HUMAN
E:
[13-308]
--------------------
Q
H
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
T
L
R
M
M
V
Q
K
E
R
S
L
D
I
L
K
G
K
V
M
A
S
M
F
Y
-
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
L
G
G
A
V
L
S
F
-
S
E
--------
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
-
A
D
V
V
V
L
R
H
P
Q
P
-
G
A
V
E
L
A
A
K
H
-
C
-
R
R
--
P
V
I
N
A
G
D
G
V
G
E
H
P
T
Q
A
L
L
D
I
F
T
I
R
E
E
L
G
T
-
V
N
G
M
T
I
T
M
V
G
D
L
K
H
G
R
T
V
H
S
-
L
A
C
L
L
T
Q
Y
R
V
S
L
R
Y
V
A
P
P
S
L
R
M
P
----
P
T
V
-----
R
A
----
F
V
A
S
R
G
T
K
Q
E
E
F
E
---
S
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
R
-----
F
G
----
Y
E
A
C
---
F
G
QFI
L
T
P
H
I
M
T
R
A
K
K
K
M
V
V
M
H
P
M
P
--
R
V
N
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
------------------
114
PsiBlast_CBE
77.97
31%
-76
- C7 -
-
3LXM
1
PYRB_YERPE
A:
[32-333]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
E
L
E
L
V
L
R
T
A
A
S
L
----
K
K
T
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
I
H
R
L
G
A
S
V
V
G
F
-
S
D
--------
G
E
T
L
A
D
T
M
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
S
R
-
L
A
A
Q
F
S
G
N
V
--
P
I
V
N
A
G
D
G
A
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
I
N
I
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
N
G
N
H
F
F
F
I
A
P
D
A
L
-
A
M
----
P
A
Y
I
L
Q
M
L
E
E
----
K
----
E
I
E
Y
S
L
H
E
---
S
L
E
E
V
V
P
E
L
D
I
L
Y
M
T
R
-------------
Y
A
N
V
K
A
Q
---
F
I
---
L
R
S
S
D
L
T
G
A
R
D
N
L
K
V
L
H
P
L
P
--
R
I
D
E
I
T
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
A
E
L
-----------
165
HHSearch
77.71
36%
-48
- C7 -
-
4BJH
10
PYRB_AQUAE
B:
[32-321]
-------------------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
-----
E
E
T
I
-
K
A
S
A
V
L
F
F
S
-
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
--
P
Y
K
E
I
V
K
S
L
N
L
--
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
-
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
G
A
-
K
I
G
V
C
G
P
K
T
L
-
I
P
----
R
D
V
-----
E
----------
V
F
K
V
D
V
F
D
---
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
---
L
T
K
E
R
F
E
K
---
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
---------------
82
PsiBlast_CBE
76.71
33%
-13
- C7 -
-
2FZG
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
81
PsiBlast_CBE
76.52
33%
-11
- C7 -
-
2FZG
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
86
PsiBlast_CBE
76.13
33%
-12
- C7 -
-
2AIR
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
88
PsiBlast_CBE
76.08
33%
-11
- C7 -
-
1ZA2
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
87
PsiBlast_CBE
76.08
33%
-13
- C7 -
-
1ZA2
2
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
122
PsiBlast_CBE
75.81
32%
-12
- C7 -
-
1TU0
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
105
PsiBlast_CBE
75.73
33%
-10
- C7 -
-
1EKX
2
PYRB_ECOLI
A:
[8-309]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
80
PsiBlast_CBE
75.70
33%
-9
- C7 -
-
2FZK
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
10
PsiBlast_PDB
75.62
33%
-9
- C7 -
-
1ML4
1
PYRB_PYRAB
A:
[2-305]
----------------
D
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
K
E
K
G
Q
L
E
Y
A
K
G
K
I
L
A
T
L
F
F
-
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
S
T
S
S
V
-
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
C
-
D
V
I
V
I
R
H
P
K
E
-
G
A
A
R
L
A
A
E
--
V
A
E
V
--
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
-
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
-
T
F
Y
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
P
R
H
I
V
E
E
L
-----
R
E
----
K
----
G
M
K
V
V
E
T
T
---
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
E
Q
E
Y
L
K
V
KGS
Y
Q
---
V
N
L
K
V
L
E
K
A
K
D
E
L
R
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
---------------
116
PsiBlast_CBE
75.59
33%
-15
- C7 -
-
2HSE
3
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
83
PsiBlast_CBE
75.54
33%
-8
- C7 -
-
2FZC
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
84
PsiBlast_CBE
75.40
33%
-9
- C7 -
-
2FZC
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
120
PsiBlast_CBE
75.38
32%
-18
- C7 -
-
1TUG
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
69
PsiBlast_CBE
75.18
33%
-9
- C7 -
-
4KGV
1
?
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
135
PsiBlast_CBE
75.16
32%
-15
- C7 -
-
3AT1
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
67
PsiBlast_CBE
75.01
33%
-10
- C7 -
-
4KGX
1
?
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
78
PsiBlast_CBE
74.98
33%
-8
- C7 -
-
2H3E
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
115
PsiBlast_CBE
74.97
33%
-15
- C7 -
-
2HSE
2
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
108
PsiBlast_CBE
74.90
32%
-8
- C7 -
-
1D09
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
72
PsiBlast_CBE
74.81
33%
-11
- C7 -
-
4F04
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
103
PsiBlast_CBE
74.76
33%
-11
- C7 -
-
1EKX
2
PYRB_ECOLI
C:
[8-309]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
89
PsiBlast_CBE
74.76
33%
-10
- C7 -
-
1R0C
1
PYRB_ECOLI
G:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
134
PsiBlast_CBE
74.69
32%
-14
- C7 -
-
3AT1
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
123
PsiBlast_CBE
74.61
32%
-8
- C7 -
-
1TU0
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
85
PsiBlast_CBE
74.60
33%
-7
- C7 -
-
2AIR
2
PYRB_ECOLI
G:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
77
PsiBlast_CBE
74.51
33%
-10
- C7 -
-
2H3E
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
61
PsiBlast_CBE
74.50
33%
-10
- C7 -
-
4KH1
1
?
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
71
PsiBlast_CBE
74.49
33%
-9
- C7 -
-
4F04
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
118
PsiBlast_CBE
74.43
32%
-11
- C7 -
-
1F1B
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
--
P
L
A
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
90
PsiBlast_CBE
74.40
33%
-11
- C7 -
-
1R0C
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
5
PsiBlast_PDB
74.40
36%
-8
- C7 -
-
4BJH
10
PYRB_AQUAE
B:
[32-319]
-------------------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
E
T
I
K
A
S
A
V
-------
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
-
F
F
P
Y
---
K
E
I
V
K
S
L
NL
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
-
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
G
A
K
-
I
G
V
C
G
P
K
T
L
-
I
P
----
R
D
V
-----
E
V
----
F
------
K
V
D
V
F
D
---
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
---
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
-----------------
121
PsiBlast_CBE
74.34
32%
-10
- C7 -
-
1TUG
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
119
PsiBlast_CBE
74.33
32%
-12
- C7 -
-
1F1B
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
--
P
L
A
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
63
PsiBlast_CBE
74.27
33%
-8
- C7 -
-
4KH0
1
?
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
109
PsiBlast_CBE
74.23
32%
-7
- C7 -
-
1D09
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
60
PsiBlast_CBE
74.13
33%
-9
- C7 -
-
4KH1
1
?
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
104
PsiBlast_CBE
74.01
33%
-7
- C7 -
-
1EKX
2
PYRB_ECOLI
B:
[8-309]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
124
PsiBlast_CBE
73.95
32%
-11
- C7 -
-
1TTH
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
66
PsiBlast_CBE
73.90
33%
-8
- C7 -
-
4KGX
1
?
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
75
PsiBlast_CBE
73.83
33%
-12
- C7 -
-
2IPO
4
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
68
PsiBlast_CBE
73.65
33%
-8
- C7 -
-
4KGV
1
?
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
137
PsiBlast_CBE
73.43
32%
-11
- C7 -
-
2AT1
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
62
PsiBlast_CBE
73.39
33%
-9
- C7 -
-
4KH0
1
?
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
76
PsiBlast_CBE
73.36
33%
-10
- C7 -
-
2IPO
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
133
PsiBlast_CBE
73.31
32%
-11
- C7 -
-
7AT1
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
130
PsiBlast_CBE
73.26
32%
-5
- C7 -
-
8AT1
2
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
129
PsiBlast_CBE
73.25
32%
-15
- C7 -
-
8ATC
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
136
PsiBlast_CBE
73.18
32%
-8
- C7 -
-
2AT1
2
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
128
PsiBlast_CBE
73.13
32%
-10
- C7 -
-
8ATC
1
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
131
PsiBlast_CBE
73.00
32%
-8
- C7 -
-
8AT1
2
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
132
PsiBlast_CBE
72.78
32%
-6
- C7 -
-
7AT1
2
PYRB_ECOLI
C:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
-
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
E
Y
ILDML
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
117
PsiBlast_CBE
71.65
33%
-12
- C7 -
-
2A0F
1
PYRB_ECOLI
A:
[7-308]
--------------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
----
E
L
L
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
A
R
-
L
A
T
E
F
S
G
N
V
--
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
-
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
-
A
M
----
P
Q
Y
I
L
D
M
L
D
E
----
K
----
G
I
A
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
E
Y
A
N
V
K
A
Q
---
F
V
---
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------