@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPH0: (2017-11-21 )
MGVDISSTSVKLLELSVKNGKYWVESYALMPLPENSVVEKNILNPEAVAEALERAMNLANPQTTHAAIAVPTSTVIHKTIEMDADMSDDEREVQIRVDAEQYIPFPLDEVSLDFEVLPDRLANPNRVNVLLVATRTENVETRVEVLELADLNPKLADVESYAVERTFSVFADSLPIGANTIGILDIGHTMTTLSVMQNGKIIYTREQVFGGKQLTLEIQSRYGLSLEEASRAKKDRSLPDDYEIEVLDPFLDAVVQQAARSLQFFFSSSQFNEIDHILLAGGNANIPGLAKLLQQKLGYRVTIANPFLQMGFSPQVDVQKIENDASSLMVACGLALRSFD
Atome Classification :
(20 SA)
-----.........10........20........30........-40-........50........----60---..-----.......70--.....------.-------..80...----.....--90-.....----------...100-----....----...110-......--.120--..------.------------------.--...130....----.---...140......-.150.......160.......170..--....------.-180--..--.......190......--.200.---......210.......220...-.-------------------...230....--------...---------------------------------------------240....---------------..-------.250.-......260.......----270-......--..-------------.280.......290.......-300..-.....310..-.-....320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----MGVDISST
S
V
K
L
L
E
L
S
VKNG
K
Y
W
V
E
S
Y
ALMPLPENS
V
V
E
-KN-IL
N
P
E
A
V
A
E
A
L
E
R
A
M
NLA----N----PQ-----TT
H
A
A
I
AV
P
--
T
S
T
V
I
------
H
-------
K
T
I
EMDA----DMSDD--E
R
-
E
V
Q
I
R
----------V
D
A
E
QY-----IPF
P
----
L
D
E
V
S
L
-
D
F
EVL
P
--
D
RLA--NP------N------------------
R
--
V
N
V
L
-
L
V
ATR----T---E
N
V
E
T
R
V
E
V
L
E
L-ADLNPK
L
A
D
V
E
S
Y
A
V
E
R
T
F
S
V
F
ADSL--PIGA------
N
-
T
----
I
G
--
I
L
DIGH
T
M
T
T
L
S
VMQN--
G
K
I
I
Y
---
T
R
E
QVFGG
K
Q
L
T
L
E
I
Q
S
RYGL
S
-
L
-------------------
E
E
A
S
R
AKKDR--------SLP---------------------------------------------DDY
E
I
E
V
---------------
L
D
-------
P
F
L
D
A
-
V
V
Q
Q
A
A
R
S
L
Q
F
F
FSSS----Q---FNEI
D
H
--
I
L
-------------LAGGNAN
I
P
G
L
A
K
L
L
Q
Q
KLG
Y
-
R
V
T
IA-
N
P
F
L
QMGFSP-Q-
V
D
V
Q
K
I
E
N
D
A
S
S
L
M
V
A
C
G
L
A
LRSFD-
23
PsiBlast_CBE
98.10
56%
0
- C- -
-
5EOU
1
?
B:
[16-359]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
-
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
------------
D
-
T
DQ
L
T
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
3
PsiBlast_PDB
90.92
55%
-75
- C1 -
-
5EOY
1
?
A:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
----
G
A
------
D
-
T
D
Q
L
T
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
22
PsiBlast_CBE
90.33
56%
-75
- C1 -
-
5EOX
1
?
B:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
----
G
A
------
D
-
T
DQLT
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
21
PsiBlast_CBE
90.29
56%
-74
- C1 -
-
5EQ6
1
?
B:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
--
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
----
G
A
------
D
-
T
DQ
L
T
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
2
PsiBlast_PDB
88.29
56%
-73
- C1 -
-
5EQ6
1
?
A:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
----
G
A
------
D
-
T
DQ
L
T
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
1
PsiBlast_PDB
86.99
56%
-58
- C1 -
-
5EOX
1
?
A:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
----
G
A
------
D
-
T
L
T
--
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
---------
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
34
HHSearch
86.60
56%
-57
- C1 -
-
5EQ6
1
?
A:
[16-357]
-----
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
V
E
P
L
P
P
N
A
V
V
E
-
K
N
-
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
K
A
----
K
----
T
N
-----
L
K
S
A
V
V
A
V
A
--
G
S
A
V
I
------
T
-------
K
T
I
E
M
E
A
----
G
L
S
E
D
--
E
L
-
E
N
Q
L
K
----------
I
E
A
D
Q
Y
-----
I
P
Y
P
----
L
E
E
V
A
I
-
D
F
E
V
Q
G
--
L
S
A
R
--
N
P
------
E
------------------
R
--
V
D
V
L
-
L
A
A
C
R
----
K
---
E
N
V
E
V
R
E
A
A
L
A
L
-
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
L
L
S
S
Q
L
G-
A
D
T
D
------
Q
L
T
----
V
A
--
V
V
D
I
G
A
T
M
T
T
L
S
V
L
H
N
--
G
R
T
I
Y
---
T
R
E
Q
L
F
G
G
R
Q
L
T
E
E
I
Q
R
R
Y
G
L
S
-
V
-------------------
E
E
A
G
L
A
K
K
Q
G
--------
G
L
P
---------------------------------------------
D
D
Y
D
S
E
V
---------------
L
R
-------
P
F
K
D
A
-
V
V
Q
Q
V
S
R
S
L
Q
F
F
F
A
A
G
----
Q
---
F
N
D
V
D
Y
--
I
V
-------------
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
T
-
P
T
L
V
A
-
N
P
F
A
D
M
A
L
N
G
-
K
-
V
N
A
G
A
L
A
S
D
A
P
A
L
M
I
A
C
G
L
A
L
R
S
F
D
-
37
HHSearch
67.95
28%
-47
- C1 -
-
2YCH
1
?
A:
[16-373]
-----
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
G
N
P
--
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
M
E
-
G
M
-
V
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
----
R
----
T
R
-----
K
R
Y
V
V
T
A
L
S
--
N
L
A
V
I
------
L
-------
R
P
I
Q
V
P
K
-----
M
P
L
K
--
E
M
-
E
E
A
V
R
----------
W
E
A
E
R
Y
-----
I
P
F
P
----
I
-
E
V
V
L
-
D
F
A
P
L
T
--
P
L
S
E
VQ
E
G
------
E
------------------
Q
--
V
Q
V
M
-
V
A
A
A
R
----
Q
---
E
A
V
A
G
V
L
E
A
L
R
G
-
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
A
E
-----
E
P
------
D
R
V
----
F
L
--
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
G
--
D
K
P
L
A
---
V
R
V
L
T
L
S
G
K
D
F
T
E
A
I
A
R
S
F
N
L
D
-
L
-------------------
L
A
A
E
E
V
K
R
T
Y
---------------------------------------------------------
G
R
I
Y
D
A
---------------
I
R
-------
P
V
L
V
E
-
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L
----------
S
P
E
V
--
G
Y
-------------
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
-
N
L
E
P
V
-
N
P
W
E
A
V
A
V
D
P
K
R
-
F
E
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
--
4
PsiBlast_PDB
66.31
27%
-35
- C1 -
-
2YCH
1
?
A:
[16-374]
-----
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
--
G
N
P
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
M
E
-
G
M
-
V
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
----
R
----
T
R
-----
K
R
Y
V
V
T
A
L
S
--
N
L
A
V
I
------
L
-------
R
P
I
Q
V
-
P
----
K
M
P
L
K
--
E
M
-
E
E
A
V
R
----------
W
E
A
E
R
Y
-----
I
P
F
P
----
I
-
E
V
V
L
-
D
F
A
P
L
T
PL
S
E
V
Q
--
E
G
------
E
------------------
Q
--
V
Q
V
M
-
V
A
A
A
R
----
Q
---
E
A
V
A
G
V
L
E
A
L
R
G
-
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
A
E
E
--
P
--
D
------
R
-
V
----
F
L
--
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
G
--
D
K
P
L
A
---
V
R
V
L
T
L
S
G
K
D
F
T
E
A
I
A
R
S
F
N
L
D
-
L
L
A
A
----------------
E
E
V
K
R
T
Y
G
----------------------------------------------------------------------------------R
I
Y
D
A
I
R
P
V
L
V
E
-
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L
----------
S
P
E
V
--
G
Y
-------------
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
-
N
L
E
P
V
-
N
P
W
E
A
V
A
V
D
P
-
K
R
F
E
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
-
24
Fugue
61.53
27%
12
- C1 -
-
2YCH
1
?
A:
[11-375]
PRVE
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
--
G
N
P
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
--M
E
G
M
V
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
----
R
----
T
R
-----
K
R
Y
V
V
T
A
L
S
--
N
L
A
V
I
------
L
-------
R
P
I
Q
V
P
K
M---
P
---
L
--
K
E
M
E
E
A
V
R
----------
W
E
A
E
R
Y
-----
I
P
F
P
----
I
-
E
V
V
L
-
D
F
A
P
L
T
--
P
L
S
E
--
V
Q
E-----
G
------------------
E
--
Q
V
Q
V
M
V
A
A
A
R
----
Q
---
E
A
V
A
G
V
L
E
A
L
R
G
-
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
A
E
E
--
P
--
D
------
R
-
V
----
F
L
--
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
G
--
D
K
P
L
A
---
V
R
V
L
T
L
S
G
K
D
F
T
E
A
I
A
R
S
F
N
L
D
-
L
-------------------
L
A
A
E
E
V
K
R
T
---------------------------------------------------------
Y
G
R
I
Y
D
A
---------------
I
R
-------
P
V
L
V
E
-
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L
----
S
------
P
E
V
--
G
Y
-------------
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
-
N
L
E
P
V
-
N
P
W
E
A
V
A
V
D
P
-
K
R
F
E
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
P
46
HHSearch
59.52
21%
-125
- C1 -
-
3H1Q
1
?
B:
[31-271]
-----
V
G
V
D
L
G
T
A
D
I
V
L
V
V
T
D
Q
E
-
G
-
I
P
V
A
G
A
L
K
W
A
S
V
---
V
K
D
-
G
L
-
V
V
D
Y
I
G
A
I
Q
I
V
R
E
L
K
A
K
V
----
E
----
R
L
-----
L
-----
G
S
E
--
L
F
Q
A
A
----------------
T
A
I
P
P
----------------------------------------------------------------------------------------------------------
G
T
V
----
G
---
R
N
A
E
A
C
G
H
V
V
A
G
-
A
G
L
E
L
V
T
L
V
D
E
P
V
A
A
A
R
A
L
G
I
N
------------------
D
----
G
I
--
V
V
D
I
G
G
G
T
T
G
I
A
V
I
E
K
--
G
K
I
T
A
---
T
F
D
E
P
T
G
G
T
H
L
S
L
V
L
A
G
S
Y
K
I
P
-
F
-------------------
E
E
A
E
T
I
K
K
D
F
--------
S
R
H
----------------------------------------------
R
E
I
M
R
V
---------------
V
R
-------
P
V
I
E
K
-
M
A
L
I
V
K
E
V
I
K
N
Y
-------------
D
Q
T
L
P
--
V
Y
-------------
V
V
G
G
T
A
Y
L
T
G
F
S
E
E
F
S
R
F
L
G
K
-
E
V
Q
V
P
----------------------
I
H
P
L
L
V
T
P
L
G
I
A
L
F
----
5
PsiBlast_PDB
53.24
26%
-144
- C1 -
-
3H1Q
1
?
A:
[136-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
I
------
N
-
D
----
G
I
--
V
V
D
I
G
G
G
T
T
G
I
A
V
I
E
K
--
G
K
I
T
A
---
T
F
D
E
P
T
G
G
T
H
L
S
L
V
L
A
G
S
Y
K
I
P
-
F
-------------------
E
E
A
E
T
I
K
K
D
F
--------
S
R
H
---------------------------------------------
R
E
I
M
-
R
V
---------------
V
R
-------
P
-----
V
I
E
K
M
A
L
I
V
K
E
V
I
K
N
---------
Y
D
Q
T
L
P
--
V
Y
-------------
V
V
G
G
T
A
Y
L
T
G
F
S
E
E
F
S
R
F
L
G
K
-
E
V
Q
V
P
I
H
P
L
L
-----------------------------------
41
HHSearch
46.95
16%
2
- C1 -
-
3WT0
1
FTSA_STAAW
C:
[25-388]
-----
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
--
T
S
G
I
K
N
-
G
L
-
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
SIAS
G
----
V
D
-----
I
K
E
V
F
L
K
L
P
II
G
T
E
V
Y
------
D
-------
E
S
N
E
I
D
F
YEDT
E
I
N
G
S
--
H
I
-
E
K
V
L
E
GIREKNDVQE
T
E
V
I
N
V
-----
F
P
I
R
FIVD
K
E
N
E
V
S
-
D
P
K
E
L
I
--
A
R
H
----
S
------
L
------------------
K
--
V
E
A
G
-
V
I
A
I
Q
----
K
---
S
I
L
I
N
M
I
K
C
V
E
A
-
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
A
T
E
--------
K
------
E
L
G
----
A
C
--
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
--
G
E
L
V
D
---
A
D
S
I
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
-
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------
G
H
A
FYDSASDQDIFTVEQVDSDETVQYT--------------------
Q
K
D
L
S
D
F
---------------
I
E
-------
A
R
V
E
E
-
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
----------
K
V
N
G
G
--
F
I
-------------
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
V
R
I
H
-
T
P
S
Q
M
--------------
G
I
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
--
40
HHSearch
46.18
16%
0
- C1 -
-
3WT0
1
FTSA_STAAW
D:
[25-388]
-----
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
--
T
S
G
I
K
N
-
G
L
-
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
SIAS
G
----
V
D
-----
I
K
E
V
F
L
K
L
P
II
G
T
E
V
Y
------
D
-------
E
S
N
E
I
D
F
YEDT
E
I
N
G
S
--
H
I
-
E
K
V
L
E
GIREKNDVQE
T
E
V
I
N
V
-----
F
P
I
R
FIVD
K
E
N
E
V
S
-
D
P
K
E
L
I
--
A
R
H
----
S
------
L
------------------
K
--
V
E
A
G
-
V
I
A
I
Q
----
K
---
S
I
L
I
N
M
I
K
C
V
E
A
-
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
A
T
E
--------
K
------
E
L
G
----
A
C
--
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
--
G
E
L
V
D
---
A
D
S
I
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
-
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------
G
H
A
FYDSASDQDIFTVEQVDSDETVQYT--------------------
Q
K
D
L
S
D
F
---------------
I
E
-------
A
R
V
E
E
-
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
----------
K
V
N
G
G
--
F
I
-------------
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
V
R
I
H
-
T
P
S
Q
M
--------------
G
I
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
--
38
HHSearch
46.12
14%
5
- C1 -
-
4A2B
1
?
A:
[11-392]
-----
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
E
-
G
E
-
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
----
E
E
Q
L
Q
K
S
L
----
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
I
E
R
D
FGE
E
K
R
S
I
T
L
D
I
-----
L
S
E
M
Q
S
E
A
-
L
E
K
L
K
----------
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
----
L
D
D
E
R
I
-
V
F
N
P
L
D
--
M
K
A
S
---
K
------
I
------------------
A
--
I
E
Y
T
-
S
I
V
V
P
----
L
---
K
V
Y
E
M
F
Y
N
F
L
Q
D
-
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
T
T
P
E
-------
K
------
D
R
G
----
V
V
--
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
S
Y
V
P
V
G
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
-
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------
G
N
A
VYNDLKE
E
E
I
Q
Y
R
G
LDGN
T
I
K
T
T
T
---------------------
A
K
K
L
S
V
I
---------------
I
H
-------
A
R
L
R
E
-
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
I
V
E
E
G
E
---
I
G
I
P
G
G
--
V
V
-------------
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
V
R
T
G
-
C
Y
A
N
S
-
D
R
P
S
-
I
-
I
N
A
D
-
E
V
A
N
D
P
S
F
A
A
A
F
G
N
V
F
A
V
S
--
39
HHSearch
41.87
14%
6
- C1 -
-
4A2A
1
?
A:
[11-390]
-----
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
----
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
E
-
G
E
-
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
----
E
E
Q
L
Q
K
S
L
----
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
I
E
R
D
FGE
E
K
R
S
I
T
L
D
I
-----
L
S
E
M
Q
S
E
A
-
L
E
K
L
K
----------
E
N
G
K
T
P
LHIFS
K
R
Y
L
----
L
D
D
E
R
I
-
V
F
N
P
L
D
--
M
K
A
S
---
K
------
I
------------------
A
--
I
E
Y
T
-
S
I
V
V
P
----
L
---
K
V
Y
E
M
F
Y
N
F
L
Q
D
-
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
T
T
P
E
-------
K
------
D
R
G
----
V
V
--
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
S
Y
V
P
V
G
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
-
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------
G
N
A
VYNDL
K
E
E
E
I
Q
Y
R
G
LDGN
T
I
K
T
T
T
---------------------
A
K
K
L
S
V
I
---------------
I
H
-------
A
R
L
R
E
-
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
-----------
I
P
G
G
--
V
V
-------------
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
V
R
T
G
-
C
Y
A
N
S
-
D
R
P
S
-
I
-
I
N
A
D
-
E
V
A
N
D
P
S
F
A
A
A
F
G
N
V
F
A
----
25
Fugue
41.29
15%
33
- C1 -
-
1E4F
-
?
T:
[7-390]
-TVFY
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
--
R
G
L
D
E
-
G
E
-
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
----
E
----
E
Q
LQKSL
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
------
R
-------
E
D
T
V
I
E
R
----
D
F
G
E
E
--
K
R
-
S
I
T
L
D
----------
I
L
S
E
M
Q
-----
S
E
A
L
----
E
K
L
K
E
N
-
G
K
T
P
L
H
--
I
F
S
K
--
R
Y
------
L
LDDERIVFNPLDMKASKI
A
--
I
E
Y
T
-
S
I
V
V
P
----
L
---
K
V
Y
E
M
F
Y
N
F
L
Q
D
-
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
-
L
T
T
P
E
K
--
D
R
G
--------------
V
V
--
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
S
Y
V
P
V
G
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
-
F
-------------------
E
E
S
E
R
L
I
I
T
H
GNAVY---
N
D
L
---------------------------------------------
K
E
E
E
I
Q
Y
RGLDGNTIKTTTAKK
L
S
-------
V
I
I
H
A
-
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
----
E
---
A
K
I
G
I
P
GG
V
V
-------------
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
V
R
T
G
-
C
Y
A
N
-
S
D
R
P
S
-
I
-
I
N
A
D
E
V
A
N
D
-
P
S
F
A
A
A
F
G
N
V
F
A
----
50
HHSearch
37.41
23%
34
- C1 -
-
3C7N
1
HSP7F_YEAST
A:
[140-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
D
V
-
C
I
A
V
P
PWYT
E
---
E
Q
R
Y
N
I
A
D
A
A
R
I
-
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
T
D
L
PE
G
E
E
K
------
P
R
I
----
V
A
--
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
-
F
K
T
K
YKIDIREN
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
--------
S
A
N
T
N
A
P
F
S
V
E
SVMND
V
D
V
S
S
Q
L
S
------------------------
R
E
E
L
E
E
L
---------------
V
K
-------
P
L
L
E
R
-
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
------
S
---
A
E
E
V
D
F
--
V
E
-------------
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
-
P
L
-------------------------------------------
11
PsiBlast_PDB
37.31
23%
4
- C1 -
-
3WQT
1
FTSA_STAAR
A:
[161-369]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
R
H
----
S
---
L
K
V
E
A
G
V
I
A
I
Q
K
-
S
I
L
I
N
M
I
K
C
V
E
A
C
G
V
D
-
V
L
D
V
Y
S
D
A
Y
--
N
Y
G
S
ILT
A
T
E
K
-
E
----
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
--
G
E
L
V
D
---
A
D
S
I
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
-
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
GHAFYDSA
S
D
Q
---------------------------------------------
D
I
F
T
V
E
Q
---------------
V
D
-------
S
--
D
E
-
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
----
V
E
E
I
F
F
E
V
F
D
--
V
L
Q
D
L
GLTKVNG
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
V
R
I
H
-
T
P
-
S
Q
M
G
--------------------------------
43
HHSearch
36.64
16%
-12
- C1 -
-
2D0O
1
DDRFA_KLEOK
C:
[283-603]
------------------------------------------------------------------------------------
A
I
M
K
A
V
D
--
G
C
G
R
L
------
D
-------
N
V
T
G
E
S
G
-----
T
N
I
G
--
G
M
-
L
E
H
V
R
----------
Q
T
M
A
E
L
-----
T
N
K
P
----
S
S
E
I
F
I
Q
D
L
L
A
V
D
--
T
S
V
P
VS
V
T
GGLAGE
F
------------------
S
LE
Q
A
V
G
-
I
A
S
M
V
----
K
SDR
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
L
T
T
P
G
-------
T
------
T
R
P
----
L
A
--
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
P
--
K
G
D
I
I
---
A
T
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
L
E
D
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
--------
L
A
K
VESLFHLRHEDGSVQFFSTPLPPAVFARVCVVKADELVPLPGDLA
L
E
K
V
R
A
I
---------------
R
R
-------
S
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
----
N
---
I
R
D
I
P
F
--
V
V
-------------
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
-
R
G
N
I
--------------
R
G
S
E
G
P
R
N
A
V
A
T
G
L
I
L
S
W
H
--