@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTU6: (2017-12-15 )
MTAMLPEWTTACPDWEERIVAKKSLMPCEPLFPQVADVAERIFKELILVDVMGSPKMGDVTLDWVIEFVRAIFGSYNPNTKRRLIREFFLLISKKNTKSTIAAGVMLVALLLNDRLSAELIILAPTKEVADNSFNPIRDFIRADEELSAMINVSEHTKTVTHLGTGATLKVIAAESNAAAGKKASIILIDEVWLFGKRANAESMFREAKGGLASRPEGCVIYLSTMSDEVPCGVFKQLLDYARDVRDGIKEDKGFLPLIYEFPKRLVEAGEHLKPEHFYITNPNLGASVDLEYLISEFKKVKDAGEESLRDFLAKHLNIEIGMNLRANRWAGAEYWNKQKHVFGLDQLIEQSDVITIGIDGGGLDDLLGYAVLGRLKKDPRVWWLWNHAWANKIALERRKENIPKYDDFKLEGSLTVVDRVGDDIDQLAAIAKKVYDSGKLNKIGLDPLGLGGLLDGLLEAGIPEESMFAVPQGYKLMSYILTTERKLAEGNLYHAGQQLMTWAAGNARVVMVGNGMRITKQESGVGKIDPLIATFNAVALMSMNPEPTNKEYNVFFV
Atome Classification :
(20 SA)
------------------------------------------------------------------------------.........10........20........30.---.-......40----.........-50.--...--....60......--..70........80........90........100.......110.......120..-------.....130.....----------...140.-------...-...150--------.-..--..---------...160----..-.-------.-------...170....----....180--.-......190----.--..------.....200-.-....-...---------.210-......-----...--220.......230--.....-..240...-----.--...250---...---....260----.-....-----------..--270-.......280-------------------.......290------....---....300...-....--------..310......-.320-------.....-..330..----------------.....340.------.-------.------------....--.350.......360..--.....370..----.....-380...---....390.------......400---------......--.410--......-.------.420...--...---------.430........440-..----------.....450........460-...--...-----..470.-------------------..---------------------..-...480..--------......490---------------------....------...-500-.......510...-....-520---.-......530----....--------------------...540-.......550...-...---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------MTAMLPEWTTACP
D
W
E
E
R
I
V
A
KKSLMPCE
P
L
F
---
P
-
Q
V
A
D
V
A
E
-----
R
I
F
K
E
L
I
L
V-DVM--GSP--KMGD
V
T
L
D
W
V
I
E
--
F
V
R
A
I
FGSYNP
N
T
K
R
R
L
I
R
E
F
F
L
L
I
SKKN
T
K
S
T
I
A
A
G
V
M
L
V
A
L
L
L
NDRLS
A
E
L
I
I
L
A-------P
T
K
E
VAD-NS
F
N
P
----------
I
R
D
F
I
RA-------
D
E
E
-
L
S
A
M
I
---------N-V
S
--
E
H---------T
K
T
V
T
H----LG-T-------G-------
A
T
L
K
V
-
I
A
AE----SNAAAG
K
--
K
-
A
S
I
I
L
I
D-E----
V
--
W
L
------FGKRA
N
---
A
-
E
S
M
F
-
R
E
A---------KG---GLASRP-----E
G
C
--
V
I
Y
L
STMSDEV
P
C
--
G
V
F
K
Q
-
L
L
D
Y
A
R
D
V
-----
R
--
D
G
I
K
ED---KGF---
L
P
L
I
Y
E
F
----
P
-
K
R
L
V
-----------EA--GEH-LKP
E
H
F
Y
I
TN-------------------PNLGA
S
V
D
L
-------
E
Y
L
I
---
S
E
F
K
K
--
V
K
D-A
G
E
E
--------
S
L
R
D
F
L
A
K
HL
N
-
I
E
I
G-------MNLRA-NRWA
G
A
E
----------------
Y
W
NKQ
K
H
-
V
------
F
-------
G
------------
L
D
Q
L
--IEQS
D
V
I
T
I
G
IDGG
G
L
--
D
D
L
L
G
Y
A
V
L
G
----RLKKD-P
R
V
W
W
L
---WNHAW
A
N
K
------
I
A
L
E
R
R
KEN---------IPKYD
D
--
F
K
L---EG
S
L
T
V
-
V
------
D
RVGD
D
I
--
D
Q
L
---------
A
A
-
I
A
K
K
V
YDSGKLN-KI----------GLDPL
G
-
L
G
G
L
L
D
G
L
L
EA--GIP--E
E
S
-----MFAV-P-------------------Q
G
---------------------
Y
K
-
L
M
S
Y
I
-
L
T
--------
T
E
R
KLAEGN---------------------
L
Y
H
A
------
G
Q
Q
-
L
M
T-WAAG
N
A
R
V
V
M
VGN-
G
M
R
I
-
T
KQ---E-SGVGKI
D
P
L
----
I
A
T
F
--------------------
N
A
V
A
L
M
-SMNPEPTNK
E
Y
N
V
-
F
FV---
34
Fugue
61.54
19%
-10
- C7 -
-
4BIJ
-
TERL_BPT7
A:
[1-476]
------------------------------------------------------------------------------
M
S
T
Q
S
N
R
N
A
L
V
V
A
Q
L
K
G
D
F
V
A
F
L
F
V
L
W
K
A
L
N
L
---
P
-
V
P
T
K
C
Q
I
-----
D
M
A
K
V
L
-----------------------------------
A
N
G
D
N
------
K
K
F
I
L
Q
A
F
R
G
I
G
K
S
F
I
T
C
A
F
V
V
W
S
L
W
R
D
P
Q
L
--
K
I
L
I
V
S
-------
A
S
K
E
R
A
D
-
A
N
S
I
F
----------
I
K
N
I
I
D
L
-------
L
P
F
-
L
S
E
L
K
---------
P
-
R
P
--
G
Q
---------
R
D
S
V
I
S
----
F
D
-
V
-------
G
PAN
P
D
H
S
P
S
V
K
S
-
V
G
I
T
----
G
Q
L
T
-
G
S
--
R
-
A
D
I
I
I
A
D
-
D
----
V
--
E
I
PSNS
A
T
M
G
A
R
E
K
---
L
-
W
T
L
V
-
Q
E
F
---------
A
A
---
L
L
K
P
L
P
-----
S
S
R
--
V
I
Y
L
G
T
P
Q
T
E
----------------
M
T
L
-----
Y
--
K
E
L
E
D
N
---
R
G
Y
---
T
T
I
I
W
--------------------------------
P
A
L
Y
P
R
T
R
E
-------------------
E
N
L
Y
Y
S
Q
R
L
-------
A
M
L
R
---
A
E
Y
D
E
--
N
P
E
-
A
L
A
G
--------
T
P
T
D
P
V
R
F
D
R
D
-
D
L
R
E
-------
R
E
L
E
Y
-
G
K
A
G
F
T
L
----------------
Q
F
M
L
N
P
N
-
L
------
S
-------
D
------------
A
E
K
Y
P-
L
R
L
R
D
A
I
V
A
A
L
D
---------------------
L
E
K
A
-
M
H
Y
Q
W
L
---
P
N
R
Q
------------------
N
---------
I
I
E
-------------
D
L
P
N
-
V
------
G
L
K
G
D
D
L
HT
Y
H
D
---------
C
S
-
N
N
S
G
Q
Y
Q
Q
K
I
L
--------------
V
I
D
P
S
G
-
R
G
K
D
E
T
G
Y
A
V
L
--
Y
T
L
--
N
G
Y
-----
I
Y
L
M
-
E
-------------------
A
G
---------------------
G
F
-
R
D
G
Y
S
-
D
K
--------
T
L
E
L
L
A
K
K
A
---------------------
K
Q
W
G
------
V
Q
T
-
V
V
Y
-
E
S
N
F
G
D
--
G
M
F
G
K
-
V
F
S
P
-
I
L
L
---
K
-
H
H
N
C
A
M
E
E
I
----
R
A
R
G
--------------------
M
K
E
M
R
I
-
C
D
T
L
E
P
V
M
Q
T
H
R
L
-
V
I
R
DEV
13
HHSearch
61.15
18%
-29
- C7 -
-
4BIJ
-
TERL_BPT7
A:
[15-473]
---------------------------------------------------------------------------------------------------------------------
L
K
G
D
F
-----
V
A
F
L
F
V
L
W
K
-
A
L
N
--
L
-------
P
V
P
T
K
C
Q
I
D
--
M
A
K
V
L
A
N
G
--------
D
N
K
K
F
I
L
Q
A
F
R
G
I
G
K
S
F
I
T
C
A
F
V
V
W
S
L
W
R
--
D
P
Q
L
K
I
L
I
V
S
-------
A
S
K
E
R
A
D
-
A
N
S
I
F
----------
I
K
N
I
I
D
L
-------
L
P
F
-
L
S
E
L
K
---------
P
-
R
P
G-
Q
R
---------
D
S
V
I
S
F
-----
D
-
V
GPAN
P
D
H
S
-------
P
S
V
K
S
-
V
G
I
T
----
G
-
Q
L
T
G
S
--
R
-
A
D
I
I
I
A
D
-
D
----
V
--
E
I
------
P
S
N
S
A
T
M
G
A
R
-
E
K
L
W
-
T
L
V
---------
Q
E
F
A
A
L
L
K
P
L
P
-----
S
S
R
--
V
I
Y
L
G
T
P
Q
T
E
--
M
--
T
L
Y
K
E
-
L
E
D
N
R
---------------------
G
Y
---
T
T
I
I
W
P
A
----
L
-
Y
P
R
T
REENLYYSQRL
A
-M
L
R
A
E
Y
D
E
N
P
E
A
L
A
G
T
-------------------
P
T
D
P
V
R
F
D
R
-------
D
D
L
R
---
E
R
E
L
E
--
Y
----
G
K
A
-----------
G
F
T
L
Q
F
M
L
-
N
P
N
L
-------
S
---
D
-
A
E
K
Y
P
L
R
LR
D
A
I
V
A
A
L
D
L
E
KAM-
H
Y
Q
W
L
P
N
-
R
QNIIE
D
L
-------
P
N
V
G
L
K
G
D
DLHTY
H
D
C
S
N
N
S
G
Q
Y
Q
Q
K
I
L
V
I
D
P
S
G
R
G
-
K
D
E
T
G
Y
A
V
L
Y
----
T
L
----
N
G
Y
I
Y
L
---
M
-
E
A
G
G
-------------------------------------------------------
F
R
D
G
Y
S
--
D
K
T
---------
L
E
L
L
A
K
K
A
K
Q
--
W
G
V
Q
T
V
----------
V
Y
E
S
N
F
G
D
G
M
F
G
K
V
F
S
P
I
--
L
L
K
H
H
N
C
A
-----
M
E
E
I
-
R
-------------------
A
R
---------------------
G
M
-
K
E
M
R
I
C
D
T
--------
L
E
P
V
M
Q
T
H
R
---------------------
L
V
I
R
---------------------------------------------------------------------------------------------------------
35
Fugue
59.96
21%
-24
- C6 -
-
5HHY
2
SPYA_HUMAN
A:
[1-385]
------------------------------------------------------------------------------
L
L
V
T
P
P
K
A
L
L
K
P
L
S
I
P
N
Q
L
L
----------
L
G
---
P
-
G
P
S
N
L
P
P
-----
R
I
M
A
A
G
G
L
Q
-
M
I
G
--
S
M
S
--
K
D
M
Y
Q
I
M
D
E
I
K
E
--
G
I
Q
Y
V
F
Q
T
R
N
P
---------
L
T
L
V
I
S
G
S
-------
G
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
-------
A
N
G
----------------------
I
W
G
Q
R
-------
A
V
D
-
I
G
E
R
I
---------
G
-
A
R
--
V
H
---------
P
M
T
-------
K
D
-
P
-------
G
-------
G
H
Y
T
L
-
Q
E
V
E
----
E
G
L
A
Q
H
K
--
P
-
V
L
L
F
L
T
-----------------------
H
---
G
-
E
S
----------------------------------------
S
T
---------
G
V
L
Q
P
-
L
------------------------
D
G
F
---
G
E
L
C
H
R
Y
----
K
C
L
L
L
V
-----------
D
S
--
V
A
S
-
L
G
G
T
P
L
Y
M
D
R
-------------------
Q
G
----
I
D
I
-------
L
Y
S
G
---
S
Q
----------------------------
K
A
L
N
-
A
P
P
G
-------
T
S
L
I
S
F
S
D
K
A
K
K
K
----------------
M
Y
S
R
K
T
K
-
P
------
F
---------------------------------
S
F
Y
L
D
I
K
W
L
--
A
N
F
W
G
C
----------
D
D
Q
-
P
R
---
M
---
Y
H
H
-------------------
T
---------
I
P
V
I
S
L
--
Y
S
L
---
R
E
S
L
A
L
-
I
------
A
E
Q
G
L
E
N
--
S
W
R
---------
Q
H
-
R
E
A
A
A
Y
L
H
G
R
L
Q
-
A
L
----------
G
L
Q
L
F
V
-
K
D
P
A
L
R
--------
L
P
--
T
V
T
-----
T
V
A
V
-
P
-------------------
A
G
---------------------
Y
------------------
D
W
R
D
I
V
S
Y
V
---------------------
I
D
H
F
------
D
I
E
-
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
A
-
T
-------------
R
E
N
----
V
D
R
V
--------------------
T
E
A
L
R
A
-
A
L
Q
H
C
P
K
K
------------
12
HHSearch
59.00
18%
-33
- C7 -
-
4BIL
-
TERL_BPT7
E:
[15-473]
---------------------------------------------------------------------------------------------------------------------
L
K
G
D
F
-----
V
A
F
L
F
V
L
W
K
-
A
L
N
--
L
-------
P
V
P
T
K
C
Q
I
D
--
M
A
K
V
L
A
N
G
--------
D
N
K
K
F
I
L
Q
A
F
R
G
I
G
K
S
F
I
T
C
A
F
V
V
W
S
L
W
R
--
D
P
Q
L
K
I
L
I
V
S
-------
A
S
K
E
R
A
D
-
A
N
S
I
F
----------
I
K
N
I
I
D
L
-------
L
P
F
-
L
S
E
L
K
---------
P
-
R
P
G-
Q
R
---------
D
S
V
I
S
F
-----
D
-
V
GPANPDH
S
-------
P
S
V
K
S
-
V
G
I
T
----
G
-
Q
L
T
G
S
--
R
-
A
D
I
I
I
A
D
-
D
----
V
--
E
I
------
P
S
N
S
A
T
MGA
R
-
E
K
L
W
-
T
L
V
---------
Q
E
FAA
L
L
K
P
L
P
-----
S
S
R
--
V
I
Y
L
G
T
P
Q
T
E
--
M
--
T
L
Y
K
E
-
L
E
D
N
R
---------------------
G
Y
---
T
T
I
I
W
P
A
----
L
-
Y
P
R
T
REENLYYSQRL
A
P
ML
R
A
E
Y
D
E
N
P
E
A
L
A
G
T
-------------------
P
T
D
P
V
R
F
D
R
-------
D
D
L
R
---
E
R
E
L
E
--
Y
----
G
K
A
-----------
G
F
T
L
Q
F
M
L
-
N
P
N
L
-------
S
---
D
-
A
E
K
Y
P
L
R
LRDAIVAALDLEKAPM
H
Y
Q
W
L
P
N
-
R
QNIIED
L
-------
P
NVGLKGDDLHTY
H
D
C
S
NN
S
G
Q
Y
Q
Q
K
I
L
V
I
D
P
S
G
R
G-
K
D
E
T
G
Y
A
V
L
Y
----
T
L
----
N
G
Y
I
Y
L
---
M
-
E
A
G
G
-------------------------------------------------------
F
R
D
G
Y
S
--
D
K
T
---------
L
E
L
L
A
K
K
A
K
Q
--
W
G
V
Q
T
V
----------
V
Y
E
S
N
F
G
D
G
M
F
G
K
V
F
S
P
I
--
L
L
K
HH
N
C
A
-----
M
E
E
I
-
R
-------------------
A
R
---------------------
G
M
-
K
E
M
R
I
C
D
T
--------
L
E
P
V
M
Q
T
H
R
---------------------
L
V
I
R
---------------------------------------------------------------------------------------------------------
9
HHSearch
50.48
11%
-
- C7 -
-
3EZK
-
TERL_BPT4
D:
[114-558]
----------------------------------------------------------------------------------------------------------------------
R
D
D
I
-----
V
Y
F
A
E
T
Y
C
A
-
I
T
H
ID
Y
-
G
--
V
I
K
V
Q
L
R
D
Y
Q
R
D
--
M
L
K
I
M
S
S
----------
K
R
M
T
V
C
N
L
S
R
Q
L
G
K
T
T
V
V
A
I
F
L
A
H
F
V
C
F
N
--
K
D
K
A
V
G
I
L
A
-------
H
K
G
S
M
S
A
-
E
V
L
D
R
----------
T
K
Q
A
I
E
L
-------
L
P
D
-
F
L
Q
P
G
---------
I
-
V
E
--
W
N
---------
K
G
S
I
E
-----
L
D
-
N
-------
G
-------
S
S
I
G
A
-
Y
A
S
S
----
P
D
A
V
R
G
N
--
S
-
F
A
M
I
Y
I
D
-
E
----
C
--
A
F
----------
I
P
---
N
F
H
D
S
W
-
L
A
I
---------
Q
P
---
V
I
S
S
G
R
-----
R
S
K
--
I
I
I
T
T
T
P
N
G
L
-----
N
H
F
Y
D
-
I
W
T
A
A
V
E
----------
G
---
K
---
S
G
F
EPY
T
A
I
W
N
S
V
----
K
-
E
--------------------------
R
L
Y
N
D
E
-------------------
D
I
-----
F
D
-------
D
G
W
Q
WSI
Q
T
I
N
G
------
S
S
L
A
-----------
Q
F
R
Q
E
H
T
A
-
A
F
E
G
-------
T
---
S
-
G
T
L
I
S
G
M
----------------
K
L
A
V
M
D
F
I
E
------
V
TPDDHGF
H
------------
Q
F
K
K
--
P
E
P
D
R
K
Y
I
A
T
L
D
C
S
E
G
RG
Q
D
Y
H
A
L
H
I
I
D
----
V
T
D
----
D
V
W
E
Q
---
V
-
G
V
L
-------------------------------------------------------
H
S
N
T
I
S
H
--
L
I
L
---------
P
D
I
V
M
R
Y
L
V
E
--
Y
N
E
C
P
V
----------
Y
I
E
L
N
S
T
G
V
S
V
A
K
S
L
Y
M
D
L-
E
Y
E
--
G
V
I
CDSYT
D
L
G
M
-
K
-------------------
Q
T
---------------------
K
R
T
K
A
V
G
C
-
S
T
--------
L
K
D
L
I
E
K
D
K
---------------------
L
I
I
-------
H
H
R
-
A
T
I
-
Q
E
F
R
T
F
S
E
K
G
-----
V
S
W
-
A
A
E
-----
E
-
G
Y
H
D
D
L
V
----
M
S
L
V
--------------------
I
F
G
W
L
S
-
T
Q
S
K
----------------
38
Fugue
48.65
16%
38
- C5 -
-
4WZR
1
PUM3_HUMAN
A:
[9-524]
--------------------------------------------------------------------------N
Y
D
I
V
V
R
A
K
Q
M
W
E
I
L
R
R
K
D
C
D
K
E
K
R
V
K
L
M
S
D
L
Q
K
L
I
---
Q
G
K
I
K
T
I
A
F
AHDS
T
R
V
I
Q
C
Y
I
Q
Y
------
G
N
E
--
E
Q
R
K
Q
A
F
E
E
L
R
D
--
D
L
V
E
L
S
---
K
A
K
Y
S
R
N
I
V
K
K
F
L
M
Y
G
S
K
P
Q
I
A
E
I
I
R
S
F
K
G
H
V
R
K
M
L
R
H
A
E
A
S
A
I
V
E
Y
A
-------
Y
N
D
K
A
----------------------------------------------------
I
L
--
E
Q
---------
R
N
M
L
T
E
----
E
L
-
Y
-------
G
-------
N
T
F
Q
L
-
Y
K
S
A
----
D
H
P
T
------------
L
D
-
K
----
V
--
L
E
------
L
-
Q
P
E
K
---
L
-
E
L
I
M
-
D
E
M
---------
K
Q
---
I
L
T
P
M
A
-----
Q
------
K
E
A
V
I
K
H
S
L
V
H
--
K
V
F
L
D
-
F
F
T
Y
A
P
------------------------------------
P
-
K
L
R
S
-----------
E
M
--
I
E
A
-
I
R
E
A
V
V
Y
L
A
H
-------------------
T
H
D
G
A
R
V
A
M
-------
H
C
L
W
---
H
G
T
P
K
--
D
R
K
-
V
I
V
K
--------
T
M
K
T
Y
V
E
K
V
A
N
----
G
-------
Q
Y
S
H
L
-
V
L
L
A
A
F
D
----------------
C
I
D
D
T
K
L
-
V
------
K
-------
Q
------------
I
I
I
S
--
E
I
I
S
S
L
P
S
I
V
N
D
K
Y
G
R
--
K
V
L
L
Y
L
L
S
P
R
DPAH
T
V
R
E
I
-
I
E
V
L
Q
K
---
G
D
G
N
A
H
S
K
------
K
D
T
E
V
R
R
R
E
---------
L
L
E
S
I
S
--
P
A
L
---
L
S
Y
L
Q
E
H
A
------
Q
E
V
V
L
D
K
--
S
A
C
---------
V
L
-
V
S
D
I
L
G
S
A
T
G
D
V
-
Q
P
----------
T
M
N
A
I
A
-
S
L
A
A
-
T
G
L
H
P
G
--
G
K
D
--
G
E
L
-----
H
I
A
E
H
P
-------------------
A
G
---------------------
H
L
-
V
L
K
W
L
-
I
E
--------
Q
D
K
K
M
K
E
N
G
REGC
F
A
K
T
L
------------
V
E
H
V
------
G
M
K
N
L
K
S
-
W
A
S
V
N
R
G
A
I
I
L
S
S
-
L
L
Q
S
-
C
-------------
D
L
E
----
V
A
N
K
--------------------
V
K
A
A
L
K
-
S
L
I
P
T
L
E
S
K
G
I
E
I
-
L
L
E
K
L-
31
Fugue
48.60
10%
32
* C5 *
-
3PVL
9
A:
[29-654]
----------------------------------------------------------------------------EE
D
L
S
E
Y
K
F
A
K
F
A
A
T
Y
F
Q
G
T
T
T
H
S
Y
T
R
R
P
L
K
Q
P
L
LYH
D
-
D
E
G
D
Q
L
A
-----
A
L
A
V
W
I
T
I
L
-
R
F
M
--
G
D
L
--
P
E
P
K
Y
H
K
I
P
V
M
T
--
K
I
Y
E
T
L
G
K
K
T
Y
K
R
E
L
Q
A
L
Q
Q
G
N
S
M
L
E
D
R
P
T
S
N
L
E
K
L
H
F
I
I
G
N
G
I
L
R
P
A
L
R
D
E
I
Y
C
Q
I
S
K
Q
L
THN
P
S
K
S
S
Y
A
-
R
G
W
I
L
----------
V
S
L
C
V
G
C
F
A
P
S
EKF
V
K
Y
-
L
R
N
F
I
H
G
GPPGY
A
P
Y
-
C
E
--
E
R
---------
L
R
R
T
F
V
----
N
G
-
T
-------
R
-------
T
Q
P
P
S
-
W
L
E
L
----
Q
A
T
K
S
K
K
P
I
M
-
L
P
V
T
F
M
D
-
G
----
T
---
T
------
K
T
L
L
T
D
---
S
-
A
T
T
A
-
R
E
L
---------
C
N
---
A
L
A
D
K
I
SLKDR
F
G
F
--
S
L
Y
I
A
L
F
D
K
V
S
S
L
--
G
S
G
S
D
H
V
M
D
A
I
S
Q
C
-----
E
--
Q
Y
A
K
E
Q
GAQ
E
R
N
---
A
P
W
R
L
F
F
----
R
-
K
E
V
F
-----------
T
P
----------
W
H
N
P
S
E
-------------------
D
N
V
A
T
N
L
I
Y
-------
Q
Q
V
V
---
R
G
V
K
F
GE
Y
R
C
-
E
K
E
D
--------
D
L
A
E
L
A
S
Q
Q
Y
F
-
V
D
Y
G
SEMI
L
E
R
L
L
S
L
V
-
P
T
Y
I
P
D
R
----------------
E
I
T
P
L
K
N
-
L
------
E
-------
K
------------
W
A
Q
L
--
A
I
A
A
H
K
K
G
I
Y
A
Q
R
R
T
D
--
S
Q
K
V
K
E
D
V
V
N
----
Y
A
R
F
K
----------
W
P
L
L
F
S
R
F
------
Y
E
A
Y
K
F
S
G
--------------
P
P
--
L
P
K
---
S
D
V
I
V
A
-
V
------
N
W
T
G
V
Y
F
--
V
D
E
---------
Q
E
-
Q
V
L
L
E
L
S
F
P
E
I
M
-
A
V
----------
S
S
S
R
G
T
-
K
M
M
A
P
S
F
T
L
A
T
--
I
K
G
--
D
E
Y
-----
T
F
T
S
-
S
-------------------
N
A
---------------------
E
D
-
I
R
D
L
V
-
V
T
--------
F
L
E
G
L
R
K
R
S
---------------------
K
Y
V
V
A
LQDNP
N
S
G
-
F
L
S
-
F
A
K
G
D
L
I
I
L
D
H
D
T
-
G
E
Q
V
-
M
N
S
---
G
-
W
A
N
G
I
N
E
R
T
K
Q
R
G
D
F
P
T
--------------------
D
C
V
Y
V
M
-
P
T
V
T
L
P
P
R
E
I
V
A
L
-
V
T
M
---
36
Fugue
48.32
18%
35
- C3 -
-
4YPL
1
?
C:
[5-542]
-----------------------------------------------------------------------------------------
L
S
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
---
T
-
K
A
L
K
E
L
D
-----
R
L
E
R
M
Q
------
Q
--
G
S
P
EA
T
V
A
R
T
Y
L
D
W
L
T
E
VP
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
Q
G
L
D
V
R
N
K
A
P
I
L
V
L
V
-------
G
P
P
G
V
G
K
-
T
S
L
G
R
SI--------
A
R
S
M
N
R
K
-------
F
H
R
-
I
S
-
L
G
---------
G
-
V
R
--
D
E
---------
A
E
I
R
G
H
----
R
R
-
T
-------
Y
-------
I
G
A
M
P
G
K
L
I
H
----
A
M
K
Q
V
G
V
--
I
-
N
P
V
I
L
L
D
-
Q
----
I
DK
M
S
------
S
D
W
R
G
D
---
P
-
A
S
A
M
-
L
E
V
LDPEQNNTF
T
D
---
H
Y
L
D
V
P
-----
Y
D
L
SK
V
F
F
I
T
T
A
N
T
L
Q
T
----
I
P
R
P
-
L
L
D
R
M
E
V
I
-----
E
IP
G
Y
T
N
M
E
---
K
Q
A
---
I
A
R
Q
Y
L
W
----
P
-
K
Q
V
R
-----------
E
S
--
G
----
M
E
G
R
I
E
V
T
D
-------------------
A
A
I
L
R
V
I
S
E
YTREAGV
R
G
L
E
---
R
E
L
G
K
--
I
A
R
-
K
G
A
K
FWLEGAWE
G
L
R
T
I
D
A
S
D
I
P
-
T
Y
L
G
---------
I
P
R
-
Y
R
P
D
K
A
E
----------------
T
E
P
Q
V
G
T
-
A
------
Q
-------
G
------------
L
A
W
T
--
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
--
S
G
K
L
S
L
T
--
G
----
Q
L
G
------
E
V
M
---
K
E
S
A
Q
A
A
L
------
T
Y
L
R
A
H
T
Q
D
---------
Y
G
L
P
E
D
--
F
Y
N
---
K
V
D
L
H
V
-
H
VPDGAT
P
K
D
G
P
S
A
--
G
I
T
---------
M
A
-
T
A
I
A
S
A
L
S
R
R
P
A
-
R
M
----------
D
I
A
M
T
G
-
E
V
S
L
R
G
K
V
M
P
I
--
G
G
V
--
K
E
K
-----
L
L
A
A
-
H
-------------------
Q
A
----------------------
G
-
I
H
K
I
V
-
L
P
--------
K
D
N
E
A
Q
L
E
E
---------------------
L
P
K
E
------
V
L
E
-
G
L
-----------------------
E
---
I
-
K
L
V
E
D
V
G
E
V
----
L
E
Y
L
----------------------------
L
L
P
E
P
T
M
P
P
V
V
--------
15
HHSearch
47.68
15%
-83
- C7 -
-
4ZNK
-
?
A:
[21-198]
------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
H
H
V
Q
L
A
--
I
H
R
S
T
------------
A
K
R
R
V
A
C
L
G
R
Q
S
G
K
S
E
A
A
S
V
E
A
V
F
E
L
F
A
--
R
P
G
S
Q
G
W
I
I
A
-------
P
T
Y
D
Q
A
E
-
I
I
F
G
R
----------
V
V
E
K
V
E
R
-------
L
A
E
-
V
F
P
A
T
E
--------
V
Q
L
Q
--
R
R
RL
R
L
L
V
H
H
Y
D
R
P
V
N
A
PGAK
R
V
-
A
-------
T
-------
S
E
F
R
G
-
K
S
A
D
R---
P
D
N
L
R
G
A
--
T
-
L
D
F
V
I
L
D
-
E
----
A
--
A
M
----------
I
P
-----
F
S
V
W
S
E
A
I
---------
E
P
---
T
L
S
V
-
R
-----
D
G
W
--
A
L
I
I
S
T
P
K
G
L
-----
N
W
F
Y
E
-
F
F
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
46.73
15%
-39
- C7 -
-
2O0J
1
TERL_BPT4
A:
[138-327]
---------------------------------------------------------------------------------------------------------------------
C
R
D
D
I
-----
V
Y
F
A
E
T
Y
C
A
-
I
T
H
ID
Y
-
G
--
V
I
K
V
Q
L
R
D
Y
Q
R
D
--
M
L
K
I
M
S
S
----------
K
R
M
T
V
C
N
L
S
R
Q
L
G
K
T
T
V
V
A
I
F
L
A
H
F
V
C
F
N
--
K
D
K
A
V
G
I
L
A
-------
H
K
G
S
M
S
A
-
E
V
L
D
R
----------
T
K
Q
A
I
E
L
-------
L
P
D
F
L
Q
P
G
I
---------
V
--
E
--
W
N
---------
K
G
S
I
E
-----
L
D
-
N
-------
G
-------
S
S
I
G
A
-
Y
A
S
S
----
P
D
A
V
R
G
N
--
S
-
F
A
M
I
Y
I
E
-
D
----
C
--
A
F
----------
I
P
---
N
F
H
D
S
W
-
L
A
I
---------
Q
P
---
V
I
S
S
G
R
-----
R
S
K
--
I
I
I
T
T
T
P
N
G
L
-----
N
H
F
Y
D
-
I
W
T
A
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
44.07
12%
-1
- C7 -
-
4IEE
1
?
A:
[35-476]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
Y
K
V
A
K
G
G
R
G
S
G
K
S
W
A
I
A
R
L
L
V
E
A
A
R
R
Q
--
P
-
V
R
I
L
C
A
R
-------
E
L
Q
N
S
I
S
D
S
V
I
R
L
----------
L
E
D
T
I
E
R
--------
E
G
-
Y
S
A
E
F
---------
E
-----
I
Q
---------
R
S
M
I
R
H
----
L
G
-
T
-------
N
-------
A
E
F
M
F
-
Y
G
I
K
NN--
P
T
K
I
K
S
L
--
E
G
I
D
I
C
W
V
E
-
E
----
A
--
E
A
----------
V
T
-----
K
E
S
W
-
D
I
L
---------
I
P
---
T
I
R
K
-
P
-----
F
S
E
--
I
W
V
S
F
N
P
K
N
I
--
L
--
D
D
T
Y
Q
-
R
F
V
V
N
P
---------------
P
---
D
D
I
---
C
L
--
L
T
V
----
N
-
Y
-----------------------------
T
D
N
-------------------
P
H
F
P
E
V
L
-
R
-------
L
E
M
E
---
E
C
K
R
-------
R
N
P
T
-----------
L
Y
R
H
I
W
L
G
-
E
P
V
S
-------
A
S
--
D
-
M
A
I
I
K
R
E
----------------
W
L
E
A
A
T
D
-
A
------
H
-------
K
-------------
K
L
G
--
W
K
A
K
G
A
V
V
S
A
H
D
P
S
D
T
G-
P
D
A
K
G
Y
A
S
R
H
----
G
------
S
V
V
K
R
---
I
-
A
E
G
-------------------------------------------------------
L
--
L
M
D
I
--
N
E
G
---------
A
D
W
A
T
S
L
A
I
E
--
D
G
A
D
H
Y
----------
L
W
D
G
D
G
V
G
A
G
L
R
R
Q
T
T
E
A
F
S
G
K
K
---
I
T
-----
A
T
M
F
-
K
-------------------
G
S
ESPFDEDAPYQANVRTIGDVF
R
N
K
R
A
Q
F
Y
-
Y
A
--------
L
A
D
R
L
Y
L
T
Y
R
A
V
V
HG
E
Y
A
D
PDD
M
L
S
F
DKEA
I
G
E
K
------
M
L
E
-
K
L
F
-
A
E
L
T
Q
I
Q
R
K
F
N
N
N
G
K
L
E
L
M
T
K
V
E
M
K
Q
K
L
G
I
P
S
P
N
L
A
----
D
A
L
M
--------------------
M
C
M
H
C
P
-
A
L
V
-----------------
22
HHSearch
43.65
14%
-108
- C7 -
-
1RIF
-
UVSW_BPT4
A:
[113-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
H
W
Y
Q
K
D
--
A
V
F
E
G
L
V
----------
N
R
R
R
I
L
N
L
P
T
S
A
G
R
S
L
I
Q
A
L
L
A
R
Y
Y
L
E
N
---
Y
E
G
K
I
L
I
I
V
-------
P
T
T
A
L
T
T
-
Q
M
A
D
D
----------
F
V
D
Y
R
L
F
-------
S
H
A
-
M
I
K
K
I
---------
G
-
G
G
-------------
A
S
K
D
D
K
----
Y
K
-
N
-------
D
-------
A
P
V
V
V
-
G
T
W
Q
T
V
V
K
Q
P
K
E
W
F
S
--
Q
-
F
G
M
M
M
N
D
-
E
----
C
--
H
L
----------
A
T
---
G
--
K
S
I
-
S
S
I
---------
I
S
---
G
L
N
-
N
C
-----
M
F
K
--
F
G
L
S
G
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
42.11
10%
-4
- C7 -
-
2O0J
1
TERL_BPT4
A:
[26-385]
MEQPINVLNDFHPLNEAGKILIKHPSL
A
E
R
K
D
E
DG
I
H
W
I
K
S
QWDG
K
W
Y
P
EK
F
S
D
Y
L
R
L
H
K
I
V
K
IPNNSDKPELFQTYK
D
K
N
N
K
R
S
R
Y
M
G
L
P
N
L
K
R
A
N
I
K
T
Q
W
T
R
E
M
V
E
E
W
---
K
-
K
C
R
D
D
I
V
-----
Y
F
A
E
T
Y
C
A
I
-
T
H
I
--
D
Y
G
--
V
I
K
V
Q
L
R
D
Y
Q
R
D
--
M
L
K
I
M
S
S
K
----------
R
M
T
V
C
N
L
S
R
Q
L
G
K
T
T
V
V
A
I
F
L
A
H
F
V
C
F
N
K
--
D
K
A
V
G
I
L
A
-------
H
K
G
S
M
S
A
-
E
V
L
D
R
----------
T
K
Q
A
I
E
L
-------
L
P
D
-
F
L
Q
P
G
---------
I
-
V
E
--
W
N
---------
K
G
S
I
E
L
-----
D
-
N
-------
G
-------
S
S
I
G
A
-
Y
A
S
S
----
P
D
A
V
R
G
N
--
S
-
F
A
M
I
Y
I
E
-
D
----
C
--
A
F
------
I
P
---
N
---
F
-
H
D
S
W
-
L
A
I
---------
Q
P
---
V
I
S
S
G
R
-----
R
S
K
--
I
I
I
T
T
T
P
N
G
L
-----
N
H
F
Y
D
-
I
W
T
A
A
V
E
G
-----
K
--
S
G
F
E
P
Y
---
T
A
I
---
W
N
S
V
K
E
R
L
Y
ND
E
-
D
I
F
D
-----------
D
G
--
W
Q
W
-
S
I
Q
T
I
N
G
S
S
L
-------------------
A
Q
F
R
Q
E
H
T
A
-------
A
F
E
G
---
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
38.33
17%
47
- C2 -
-
1YVU
-
?
A:
[4-706]
----------------------------------------------------------------------EALLN
L
Y
R
I
E
Y
R
P
K
D
T
T
F
T
V
F
K
P
T
H
E
I
Q
K
E
K
L
N
K
V
R
W
R
V
F
---
L
-
Q
T
G
L
P
T
F
-----
R
R
E
D
E
F
W
C
A
G
K
V
E
--
K
D
T
--
L
Y
L
T
L
S
N
G
E
I
V
E
--
L
K
R
V
G
E
E
E
F
R
G
F
Q
N
E
R
E
C
Q
E
L
F
R
D
F
L
T
K
T
K
V
K
D
K
F
I
S
D
F
Y
K
K
F
R
D
K
I
T
V
Q
G
K
N
R
K
I
A
-------
L
I
P
E
V
N
E
-
K
V
L
K
S
EE
G
Y
F
L
LH
L
D
L
K
F
R
I
Q
P
-------
F
E
T
-
L
Q
T
L
L
---------
E
-
R
N
--
D
F
---------
N
P
K
R
I
R
----
V
K
P
I
-------
G
-------
I
D
F
V
G
-
R
V
Q
D
----
V
F
K
A
K
E
K
--
G
-
E
E
F
F
R
L
C
M
E
---------------
R
S
T
H
K
S
---
S
-
K
K
A
W
-
E
E
L
---------
L
K
---
N
R
E
L
R
E
-----
K
A
F
--
L
V
V
L
-
E
K
G
Y
T
Y
P
A
--
T
I
L
K
P
-
V
L
T
Y
E
R
N
E
V
A
DIV
R
M-
E
P
G
K
R
L
---
N
L
I
---
R
Y
I
L
R
R
Y
----
V
-
K
A
L
R
-----------
D
Y
--
G
W
Y
-
I
S
P
E
E
E
R
A
K
G
K
L
N
F
KD
T
V
L
D
AK
G
K
N
T
K
V
I
T
N
L
R
K
F
L
E
L
CRPFVKK
D
V
L
S
---
V
E
I
I
S
--
V
S
V
W
R
K
E
E
--------
F
L
K
E
L
I
N
F
L
K
N
-
K
G
I
K
-------
L
K
I
K
G
-
K
S
L
I
L
A
Q
T---------------
R
E
E
A
K
E
K
-
L
------
I
-------
P
------------
V
I
N
K
--
I
K
D
V
D
L
V
I
V
F
L
E
-------
F
L
L
Y
D
F
V
K
R
----
E
L
L
K
K
M
I
P
S
Q
V
I
---
L
N
R
T
L
K
N
E
N
L
K
F
--
V
L
L
N
V
A
E
Q
V
---------
L
A
K
T
G
N
IP
Y
K
L
KEI
E
G
K
V
D
A
-
F
--------
V
G
I
D
I
--
S
R
I
T
R
DGKTV
N
A
V
A
-
F
T
K
I
F
N
S
K
G
E
L
V
-
R
Y
Y
L
T
S
Y
P
A
FGE
K
L
T
E
K
A
-
I
G
D
V
F
S
L
L
E
K
L
--
G
F
K
--
K
G
S
-----
K
I
V
V
-
H
R
DGRLY
R
D
E
V
A
A
F
K
K
Y
G
E
L
Y
G
---------------------
Y
S
-
L
E
L
L
E
-
I
I
KRN
N
P
R
F
F
S
N
E
K
F
I
K
G
Y
---------------------
F
Y
K
L
------
S
E
D
-
S
V
I
-
L
A
T
Y
N
Q
V
Y
E
G
T
H
Q
-
P
I
K
V
-
R
K
V
YG-
E
-
L
P
V
E
V
L
C
S
Q
----
I
L
S
L
T
L
M
N
YSSFQPIKLPATVHY
S
D
K
I
T
K
L
M
L
R
G
I
E
P
I
K
K
E
G
D
I
M
Y
W
L
---
26
HHSearch
34.93
18%
-161
- C7 -
-
5GJU
1
?
A:
[23-99]
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
P
I
Q
A
E
--
C
I
P
H
L
L
N
----------
G
R
D
V
L
G
M
A
Q
T
G
S
G
K
T
A
A
F
S
L
P
L
L
Q
N
L
D
P
E
-
L
K
A
P
Q
I
L
V
L
A
-------
P
T
R
E
L
A
V
-
Q
V
A
E
A
----------
M
T
D
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
34.71
15%
66
- C6 -
-
1CS8
-
CATL1_HUMAN
A:
[1-220]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
F
D
H
S
L
E
A
Q
W
T
K
W
K
A
M
H
N
R
L
Y
G
M
N
E
E
G
W
R
R
A
V
W
E
K
N
M
K
M
I
E
L
H
N
Q
E
-------
Y
R
E
G
K
H
S
-
F
T
M
A
M
----------
N
A
F
G
D
M
T
-------
S
E
E
-
F
R
Q
V
M
---------
N
-
G
F
--
Q
N
---------
R
K
P
R
K
G
----
K
V
-
F
-------
Q
-------
E
P
L
F
Y
-
E
A
P
R
----
S
V
D
W
R
E
K
--
G
-
Y
V
T
P
V
K
N
-
Q
GQCG
S
--
W
A
------
F
S
A
T
G
A
---
L
-
E
G
Q
M
-
F
R
K
---------
T
G
---
R
L
I
S
L
S
-----
E
Q
N
--
L
V
D
C
S
G
P
Q
G
N
E
G
C
NG
G
L
M
D
Y
-
A
F
Q
Y
V
Q
D
N
--------
G
G
L
D
S
E
---
E
----------
S
Y
----
P
-
Y
E
A
T
-----------
E
E
--
S
C
K
-
Y
N
P
K
Y
S
V
A
N
---------------------------------------
D
---
A
G
F
V
D
--
I
P
K
--
Q
E
K
--------
A
L
M
K
A
V
A
T
V
G
P
-
I
S
V
A
-------
I
D
A
G
H
-
E
S
F
L
----------------------------------
F
-------
Y
------------
K
E
G
I
--
Y
F
E
P
D
C
S
S
E
D
M
D
H
G
V
L
----
V
V
G
Y
G
F
E
S
----
T
E
S
D
N
-
N
K
Y
W
L
V
K
N
S
W
G
E
E
W
G
M
G
G
Y
----
V
K
M
A
K
D
R
R
N
HCGIAS
A
A
S
Y
P
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
33.74
11%
9
* C6 *
-
1XKG
2
PEPT1_DERPT
A:
[4-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
K
T
F
E
E
Y
K
K
A
F
N
K
S
Y
A
T
F
E
D
E
E
A
A
R
K
N
F
L
E
S
V
K
Y
V
Q
S
N
G
G
-------
A
I
N
H
L
S
D
-
L
S
L
D
E
----------
F
K
N
R
F
L
M
-------
S
A
E
-
A
F
E
H
L
---------
K
-
T
Q
FD
N
A
---------
C
S
I
N
G
N
----
A
P
-
A
-------
E
-------
I
D
L
R
Q
-
M
R
T
V
----
T
P
I
R
M
Q
G
--
G
-
C
G
S
----------
A
--
W
A
------
F
S
G
V
A
A
---
T
-
E
S
A
Y
-
L
A
Y
---------
R
D
---
Q
S
L
D
L
A
-----
E
Q
E
--
L
V
D
C
A
S
---
Q
H
G
C
HG
D
T
I
P
R
-
G
I
E
Y
I
Q
H
N
---------
G
V
V
Q
E
---
S
Y
Y
--------------
R
-
Y
V
A
R
-----------
E
Q
--
S
C
R
-
R
P
N
A
Q
R
F
----------------------------------------
G
I
---
S
N
Y
C
Q
--
I
Y
P
-
P
N
A
N
--------
K
I
R
E
A
L
A
Q
T
H
S
A
I
A
V
I
-------
I
G
I
K
------------------------------------------------
D
------------
L
D
A
F
--
R
H
Y
D
G
R
T
I
I
Q
R
D
N
G
Y
Q
--
P
N
Y
H
A
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N
I
V
G
----
Y
S
N
A
Q
-
G
V
D
Y
W
I
---
V
R
N
S
W
D
T
N
WGDNG
Y
G
Y
F
A
A
N
I
D
L
---------
M
----
M
--
I
E
E
---
Y
P
Y
V
V
I
-
L
------
G
Q
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
33.08
15%
-35
- C7 -
-
5M1K
1
?
B:
[33-190]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
H
I
Y
C
I
G
A
D
F
G
K
N
--
Q
D
Y
S
V
F
S
V
L
D
----
L
D
T
----
G
A
-
I
A
---
C
L
E
-
R
--------------------------------------------------------
M
N
G
A
T
W
--
S
D
Q
---------
V
A
R
L
K
A
L
S
E
D
--
Y
G
H
A
Y
V
----------
V
A
D
T
W
G
V
G
D
A
I
A
E
E
L
D
A
Q
--
G
I
N
---
Y
T
-----
P
L
P
V
-
K
-------------------
S
S
---------------------
S
V
-
K
E
Q
L
I
-
S
N
--------
L
A
L
L
M
E
K
G
Q
---------------------
V
A
V
P
------
N
D
K
-
T
I
L
-
D
E
L
R
N
F
R
Y
Y
R
T
A
S
G
N
Q
V
M
-
R
A
Y
-----
G
-
R
G
H
D
D
I
V
----
M
S
L
A
--------------------
L
A
Y
S
Q
Y
-
E
-------------------
18
HHSearch
33.01
15%
-35
- C7 -
-
5M1P
-
?
B:
[33-190]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
H
I
Y
C
I
G
A
D
F
G
K
N
--
Q
D
Y
S
V
F
S
V
L
D
----
L
D
T
----
G
A
-
I
A
---
C
L
E
-
R
--------------------------------------------------------
M
N
G
A
T
W
--
S
D
Q
---------
V
A
R
L
K
A
L
S
E
D
--
Y
G
H
A
Y
V
----------
V
A
D
T
W
G
V
G
D
A
I
A
E
E
L
D
A
Q
--
G
I
N
---
Y
T
-----
P
L
P
V
-
K
-------------------
S
S
---------------------
S
V
-
K
E
Q
L
I
-
S
N
--------
L
A
L
L
M
E
K
G
Q
---------------------
V
A
V
P
------
N
D
K
-
T
I
L
-
D
E
L
R
N
F
R
Y
Y
R
T
A
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G
N
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V
M
-
R
A
Y
-----
G
-
R
G
H
D
D
I
V
----
M
S
L
A
--------------------
L
A
Y
S
Q
Y
-
E
-------------------
10
HHSearch
31.78
12%
-
- C- -
-
4IDH
-
?
A:
[15-456]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
Y
K
V
A
K
G
G
R
G
S
G
K
S
W
A
I
A
R
L
L
V
E
A
A
R
R
Q
--
P
-
V
R
I
L
C
A
R
-------
E
L
Q
N
S
I
S
D
S
V
I
R
L
----------
L
E
D
T
I
E
R
--------
E
G
-
Y
S
A
E
F
---------
E
-----
I
Q
---------
R
S
M
I
R
H
----
L
G
-
T
-------
N
-------
A
E
F
M
F
-
Y
G
I
K
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P
T
K
I
K
S
L
--
E
G
I
D
I
C
W
V
E
-
E
----
A
--
E
A
----------
V
T
-----
K
E
S
W
-
D
I
L
---------
I
P
---
T
I
R
K
-
P
-----
F
S
E
--
I
W
V
S
F
N
P
K
N
I
--
L
--
D
D
T
Y
Q
-
R
F
V
V
N
P
---------------
P
---
D
D
I
---
C
L
--
L
T
V
----
N
-
Y
-----------------------------
T
D
N
-------------------
P
H
F
P
E
V
L
-
R
-------
L
E
M
E
---
E
C
K
R
-------
R
N
P
T
-----------
L
Y
R
H
I
W
L
G
-
E
P
V
S
-------
A
S
--
D
-
M
A
I
I
K
R
E
----------------
W
L
E
A
A
T
D
-
A
------
H
-------
K
-------------
K
L
G
--
W
K
A
K
G
A
V
V
S
A
H
D
P
S
D
T
G-
P
D
A
K
G
Y
A
S
R
H
----
G
------
S
V
V
K
R
---
I
-
A
E
G
-------------------------------------------------------
L
--
L
M
D
I
--
N
E
G
---------
A
D
W
A
T
S
L
A
I
E
--
D
G
A
D
H
Y
----------
L
W
D
G
D
G
V
G
A
G
L
R
R
Q
T
T
E
A
F
S
G
K
K
---
I
T
-----
A
T
M
F
-
K
-------------------
G
S
ESPFDEDAPYQAVRTIGDVF-
R
N
K
R
A
Q
F
Y
-
Y
A
--------
L
A
D
R
L
Y
L
T
Y
R
A
V
V
HG
E
Y
A
D
PDD
M
L
S
F
DKEA
I
G
E
K
------
M
L
E
-
K
L
F
-
A
E
L
T
Q
I
Q
R
K
F
N
N
N
G
K
L
E
L
M
T
K
V
E
M
K
Q
K
L
G
I
P
S
P
N
L
A
----
D
A
L
M
--------------------
M
C
M
H
C
P
-
A
L
V
-----------------