@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1829: (2018-01-20 )
MILKIEDLVMSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGADIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Atome Classification :
(46 SA)
.........10........20........30...-----.-----..-..40...----.....50........60........70.....---..-.80....--....90....-----...------.100........110.......120.......130.......--140..--.....150.......160.......170.......180.......190.......200.......210.......220.......230....-...240......----.250-.---.---.--......260.......270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIL
K
I
E
D
L
V
M
S
I
I
STDLT
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V-----H-----SE-DYSTN
A
I
----FDHHGQ
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F---DA-
E
V
T
FQNP--HQFKDGDRLT-----S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
C
I
K
--
V
F
DTRKTTPN
L
R
L
F
E
K
Y
A
V
R
VGGGYN
H
R
FNLS
D
A
I
M
L
KDN
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
AYAPF
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
AAAG
A
D
I
I
M
LDNM
S
-
L
E
Q
I
E
Q
A
I
T
L
IA----GR---
S
---
R
---
I
--
E
CSGNI
D
M
T
T
I
S
R
FR
G
L
A
I
D
Y
VSSGSLTHSAKSL
D
F
SMKG
L
T
YLDV
2
PsiBlast_PDB
98.52
98%
-142
- C6 -
-
5HUL
-
?
A:
[30-313]
-------------
S
T
D
L
T
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V
-----
H
-----
S
E
-
D
Y
S
T
N
A
I
----
F
D
H
H
G
Q
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F
---
D
--
E
V
T
F
Q
N
P
--
H
Q
F
K
D
G
D
R
L
T
-----
S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
R
I
K
--
V
F
D
T
R
K
T
T
P
N
L
R
L
F
E
K
Y
A
V
R
V
G
G
G
Y
N
H
R
F
N
L
S
D
A
I
M
L
K
D
N
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
A
Y
A
P
F
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
A
A
A
G
V
D
I
I
M
L
D
N
M
S
-
L
E
Q
I
E
Q
A
I
T
L
I
A
----
G
R
---
S
---
R
---
I
--
E
C
S
G
N
I
D
M
T
T
I
S
R
F
R
G
L
A
I
D
Y
V
S
S
G
S
L
T
H
S
A
K
S
L
D
F
S
M
K
G
L
T
Y
L
D
-
3
PsiBlast_PDB
98.32
98%
-148
- C6 -
-
5HUO
-
?
A:
[31-313]
--------------
T
D
L
T
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V
-----
H
-----
S
E
-
D
Y
S
T
N
A
I
----
F
D
H
H
G
Q
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F
---
D
--
E
V
T
F
Q
N
P
--
H
Q
F
K
D
G
D
R
L
T
-----
S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
R
I
K
--
V
F
D
T
R
K
T
T
P
N
L
R
L
F
E
K
Y
A
V
R
V
G
G
G
Y
N
H
R
F
N
L
S
D
A
I
M
L
K
D
N
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
A
Y
A
P
F
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
A
A
A
G
V
D
I
I
M
L
D
N
M
S
-
L
E
Q
I
E
Q
A
I
T
L
I
A
----
G
R
---
S
---
R
---
I
--
E
C
S
G
N
I
D
M
T
T
I
S
R
F
R
G
L
A
I
D
Y
V
S
S
G
S
L
T
H
S
A
K
S
L
D
F
S
M
K
G
L
T
Y
L
D
-
1
PsiBlast_PDB
96.62
99%
-137
- C6 -
-
5HUP
-
?
A:
[30-314]
-------------
S
T
D
L
T
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V
-----
H
-----
S
E
-
D
Y
S
T
N
A
I
----
F
D
H
H
G
Q
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F
---
D
A
-
E
V
T
F
Q
N
P
--
H
Q
F
K
D
G
D
R
L
T
-----
S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
R
I
K
--
V
F
D
T
R
K
T
T
P
N
L
R
L
F
E
K
Y
A
V
R
V
G
G
G
Y
N
H
R
F
N
L
S
D
A
I
M
L
K
D
N
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
A
Y
A
P
F
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
A
A
A
G
V
D
I
I
M
L
D
N
M
S
-
L
E
Q
I
E
Q
A
I
T
L
I
A
----
G
R
---
S
---
R
---
I
--
E
C
S
G
N
I
D
M
T
T
I
S
R
F
R
G
L
A
I
D
Y
V
S
S
G
S
L
T
H
S
A
K
S
L
D
F
S
M
K
G
L
T
Y
L
D
-
120
HHSearch
84.41
98%
-16
- C6 -
-
5HUP
-
?
B:
[30-314]
-------------
S
T
D
L
T
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V
-----
H
-----
S
E
-
D
Y
S
T
N
A
I
----
F
D
H
H
G
Q
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F
---
D
A
-
E
V
T
F
--
Q
NP
H
Q
F
K
D
G
D
R
L
T
-----
S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
R
I
K
--
V
F
D
T
R
K
T
T
P
N
L
R
L
F
E
K
Y
A
V
R
V
G
G
G
Y
N
H
R
F
N
L
S
D
A
I
M
L
K
D
N
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
A
Y
A
P
F
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
A
A
A
G
V
D
I
I
M
L
D
N
M
S
-
L
E
Q
I
E
Q
A
I
T
L
I
A
----
G
R
---
S
---
R
---
I
--
E
C
S
G
N
I
D
M
T
T
I
S
R
F
R
G
L
A
I
D
Y
V
S
S
G
S
L
T
H
S
A
K
S
L
D
F
S
M
K
G
L
T
Y
L
D
-
119
HHSearch
83.86
97%
-9
- C6 -
-
5HUO
-
?
B:
[31-313]
--------------
T
D
L
T
P
F
Q
I
D
D
T
L
K
A
A
L
R
E
D
V
-----
H
-----
S
E
-
D
Y
S
T
N
A
I
----
F
D
H
H
G
Q
A
K
V
S
L
F
A
K
E
A
G
V
L
A
G
L
T
V
F
Q
R
V
F
T
L
F
---
D
E
V
T
F
Q
N
--
P
--
H
Q
F
K
D
G
D
R
L
T
-----
S
G
D
------
L
V
L
-
E
I
I
G
S
V
R
S
L
L
T
C
E
R
V
A
L
N
F
L
Q
H
L
S
G
I
A
S
M
T
A
A
Y
V
E
A
L
G
--
D
D
R
I
K
--
V
F
D
T
R
K
T
T
P
N
L
R
L
F
E
K
Y
A
V
R
V
G
G
G
Y
N
H
R
F
N
L
S
D
A
I
M
L
K
D
N
H
I
A
A
V
G
S
V
Q
K
A
I
A
Q
A
R
A
Y
A
P
F
V
K
M
V
E
V
E
V
E
S
L
A
A
A
E
E
A
A
A
A
G
V
D
I
I
M
L
D
N
M
S
-
L
E
Q
I
E
Q
A
I
T
L
I
A
----
G
R
---
S
---
R
---
I
--
E
C
S
G
N
I
D
M
T
T
I
S
R
F
R
G
L
A
I
D
Y
V
S
S
G
S
L
T
H
S
A
K
S
L
D
F
S
M
K
G
L
T
Y
L
D
-
128
HHSearch
82.28
46%
-126
- C6 -
-
1X1O
-
?
C:
[10-285]
-----------------
W
Q
G
G
L
E
E
A
L
R
A
W
L
R
E
D
L
-----
G
-----
Q
G
-
D
L
T
S
L
L
V
----
V
P
E
D
L
E
G
E
A
V
I
L
A
K
E
G
G
V
L
A
G
L
W
V
A
E
R
V
F
A
L
A
---
D
P
-
R
T
A
F
--
T
--
P
L
V
A
E
G
A
R
V
A
-----
E
G
T
------
E
V
A
-
R
V
R
G
P
L
R
G
I
L
A
G
E
R
L
A
L
N
L
L
Q
R
L
S
G
I
A
T
L
T
R
A
Y
V
E
A
L
A
--
G
T
K
A
Q
--
I
L
D
T
R
K
T
T
P
G
L
R
A
L
E
K
Y
A
V
R
V
G
G
G
R
N
H
R
Y
G
L
F
D
G
I
L
L
K
E
N
H
V
R
A
A
G
G
V
G
E
A
V
R
R
A
K
A
R
A
P
H
Y
L
K
V
E
V
E
V
R
S
L
E
E
L
E
E
A
L
E
A
G
A
D
L
I
L
L
D
N
F
P
-
L
E
A
L
R
E
A
V
R
R
V
G
----
G
R
---
V
---
P
---
L
--
E
A
S
G
N
M
T
L
E
R
A
K
A
A
A
E
A
G
V
D
Y
V
S
V
G
A
L
T
H
S
A
K
A
L
D
L
S
L
L
V
V
R
----
4
PsiBlast_PDB
82.00
45%
-125
- C6 -
-
1X1O
-
?
A:
[10-281]
-----------------
W
Q
G
G
L
E
E
A
L
R
A
W
L
R
E
D
L
-----
G
-----
Q
G
-
D
L
T
S
L
L
V
----
V
P
E
D
L
E
G
E
A
V
I
L
A
K
E
G
G
V
L
A
G
L
W
V
A
E
R
V
F
A
L
A
---
D
P
-
R
T
A
F
T
P
----
L
V
A
E
G
A
R
V
A
-----
E
G
T
------
E
V
A
-
R
V
R
G
P
L
R
G
I
L
A
G
E
R
L
A
L
N
L
L
Q
R
L
S
G
I
A
T
L
T
R
A
Y
V
E
A
L
A
--
G
T
K
A
Q
--
I
L
D
T
R
K
T
T
P
G
L
R
A
L
E
K
Y
A
V
R
V
G
G
G
R
N
H
R
Y
G
L
F
D
G
I
L
L
K
E
N
H
V
R
A
A
G
G
V
G
E
A
V
R
R
A
K
A
R
A
P
H
Y
L
K
V
E
V
E
V
R
S
L
E
E
L
E
E
A
L
E
A
G
A
D
L
I
L
L
D
N
F
P
-
L
E
A
L
R
E
A
V
R
R
V
G
----
G
R
---
V
---
P
---
L
--
E
A
S
G
N
M
T
L
E
R
A
K
A
A
A
E
A
G
V
D
Y
V
S
V
G
A
L
T
H
S
A
K
A
L
D
L
S
L
--------
126
HHSearch
74.72
35%
-138
- C6 -
-
3TQV
-
?
B:
[14-286]
----------------
V
P
N
D
I
V
T
R
L
V
R
E
S
L
A
E
D
I
-----
A
-----
T
G
-
D
I
T
A
Q
L
A
------
E
D
I
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
E
V
I
N
Q
L
---
D
K
-
N
I
Q
I
--
T
--
W
L
Y
S
D
A
Q
K
V
P
-----
A
N
A
------
R
I
F
-
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
T
A
T
V
T
N
K
L
V
K
L
I
S
--
Q
Y
K
T
K
--
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
R
S
A
G
G
I
A
K
A
V
T
K
A
K
K
L
D
S
-
N
K
V
V
E
V
E
V
T
N
L
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
-
G
E
D
I
D
I
A
V
S
I
A
R
----
G
K
---
V
---
A
---
L
--
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
-----
8
PsiBlast_PDB
72.57
40%
-44
- C6 -
-
5AYX
-
NADC_HUMAN
A:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
T
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
52
PsiBlast_CBE
72.38
40%
-44
- C6 -
-
5AYY
2
NADC_HUMAN
H:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
11
PsiBlast_PDB
72.36
40%
-47
- C6 -
-
5AYY
2
NADC_HUMAN
A:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
F
PS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
9
PsiBlast_PDB
72.25
40%
-46
- C6 -
-
4KWW
2
NADC_HUMAN
A:
[14-288]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
T
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
F
PS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
65
PsiBlast_CBE
72.16
40%
-47
- C6 -
-
2JBM
2
NADC_HUMAN
F:
[12-286]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
50
PsiBlast_CBE
72.10
40%
-48
- C6 -
-
5AYZ
1
NADC_HUMAN
B:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
48
PsiBlast_CBE
72.07
40%
-47
- C6 -
-
5AYZ
1
NADC_HUMAN
D:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
10
PsiBlast_PDB
72.07
40%
-45
- C6 -
-
4KWV
-
NADC_HUMAN
A:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
T
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
F
PS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
37
PsiBlast_CBE
72.03
40%
-46
- C6 -
-
4KWW
2
NADC_HUMAN
D:
[14-288]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
T
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
44
PsiBlast_CBE
72.02
40%
-48
- C6 -
-
5AYZ
1
NADC_HUMAN
H:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
40
PsiBlast_CBE
72.01
40%
-44
- C6 -
-
5AYZ
1
NADC_HUMAN
L:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
57
PsiBlast_CBE
71.98
40%
-51
- C6 -
-
5AYY
2
NADC_HUMAN
C:
[10-284]
----------------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
-----
P
-----
G
L
-
N
Y
A
--
A
L
----
V
S
G
A
G
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
T
Q
L
---
N
C
-
Q
V
S
W
F
L
P
------
E
G
S
K
L
V
-----
P
V
A
------
R
V
A
-
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
--
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
-
P
E
E
L
H
P
T
A
T
V
L
K
----
A
Q
FPS
V
---
A
---
V
--
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
-------
132
HHSearch
67.67
37%
-95
- C6 -
-
2B7N
1
NADC_HELPY
B:
[2-273]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
V
L
----
E
-
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
------
G
I
E
C
--
V
--
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
-
V
L
E
T
K
-
E
I
A
A
Y
R
DAHY
P
F
---
V
---
L
---
L
--
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
A
-----
93
PsiBlast_CBE
65.77
38%
-82
- C6 -
-
2B7P
1
NADC_HELPY
C:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
19
PsiBlast_PDB
65.57
38%
-81
- C6 -
-
2B7N
1
NADC_HELPY
A:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
5
PsiBlast_PDB
65.51
41%
-20
- C6 -
-
1QAP
2
NADC_SALTY
A:
[29-294]
----------------------------
A
L
R
E
D
L
-----
G
-----
G
E
-
V
D
A
G
N
D
I
TAQL
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
AGD
D
V
-
R
L
T
W
H
------
V
D
D
G
D
A
I
H
-----
A
N
Q
------
T
V
F
-
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
--
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
V
P
-
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
-
T
D
Q
M
R
E
A
V
K
R
V
N
----
G
Q
---
A
---
R
---
L
--
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
-------
96
PsiBlast_CBE
65.18
38%
-79
- C6 -
-
2B7N
1
NADC_HELPY
B:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
90
PsiBlast_CBE
65.14
38%
-77
- C6 -
-
2B7Q
1
NADC_HELPY
C:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
20
PsiBlast_PDB
64.98
38%
-76
- C6 -
-
2B7P
1
NADC_HELPY
A:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
95
PsiBlast_CBE
64.73
38%
-80
- C6 -
-
2B7N
1
NADC_HELPY
C:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
129
HHSearch
64.42
40%
3
- C6 -
-
1QAP
2
NADC_SALTY
A:
[19-296]
------------------
N
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
-----
G
GEVDA
G
N
-
D
I
T
A
Q
L
L
-----
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
A--
G
D
-
D
V
R
L
--
T
--
W
H
V
D
D
G
D
A
I
H
-----
A
N
Q
------
T
V
F
-
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
--
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
-
D
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
-
T
D
Q
M
R
E
A
V
K
R
V
N
----
G
Q
---
A
---
R
---
L
--
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-----
94
PsiBlast_CBE
64.19
38%
-80
- C6 -
-
2B7P
1
NADC_HELPY
B:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
34
PsiBlast_CBE
63.62
41%
-23
- C6 -
-
1QAP
1
NADC_SALTY
B:
[29-294]
----------------------------
A
L
R
E
D
L
-----
G
-----
G
E
-
V
D
A
G
N
D
I
TAQL
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
AGD
D
V
-
R
L
T
W
H
------
V
D
D
G
D
A
I
H
-----
A
N
Q
------
T
V
F
-
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
--
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
V
P
-
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
-
T
D
Q
M
R
E
A
V
K
R
V
N
----
G
Q
---
A
---
R
---
L
--
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
-------
91
PsiBlast_CBE
63.49
38%
-75
- C6 -
-
2B7Q
1
NADC_HELPY
B:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
LL
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
124
HHSearch
63.01
32%
4
- C6 -
-
3L0G
2
?
C:
[22-295]
-----------------
M
K
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
-----
G
D----
K
G
-
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
--
E
--
I
H
K
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
-----
109
Fugue
62.77
38%
2
- C6 -
-
1QAP
2
NADC_SALTY
A:
[8-296]
-------
D
D
R
R
D
A
L
L
E
R
I
N
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
GGEVD
A
-----
G
N
-
D
I
T
A
Q
L
-----
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
---
A
G
--
D
D
V
R
L
T
--
W
H
V
D
D
G
D
A
I
H
-----
A
N
Q
------
T
V
F
-
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
--
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
V
P
-
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
-
T
D
Q
M
R
E
A
V
K
R
V
N
----------GQA
R
---
L
--
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-----
92
PsiBlast_CBE
62.70
38%
-76
- C6 -
-
2B7Q
1
NADC_HELPY
A:
[2-271]
--------------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
-----
G
-----
H
G
-
D
L
F
E
R
-
V
----
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
E
M
T
---
G
I
-
E
C
V
------
Q
T
I
K
D
K
E
R
F
K
-----
P
K
D
------
A
L
M
-
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
--
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
----
H
Y
---
P
---
F
---
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
-------
125
HHSearch
62.23
32%
4
- C6 -
-
3L0G
2
?
B:
[24-296]
-------------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
-----
G
D----
K
G
-
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
--
E
--
I
H
K
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
Y
----
100
PsiBlast_CBE
59.03
34%
14
- C6 -
-
3L0G
2
?
A:
[33-292]
----------------------------
A
L
K
E
D
L
-----
G
-----
D
K
G
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
E
-
I
--
H
K
-
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
--------
98
PsiBlast_CBE
58.91
34%
15
- C6 -
-
3L0G
2
?
C:
[33-292]
----------------------------
A
L
K
E
D
L
-----
G
-----
D
K
G
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
E
-
I
--
H
K
-
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
--------
97
PsiBlast_CBE
58.58
34%
13
- C6 -
-
3L0G
2
?
D:
[33-292]
----------------------------
A
L
K
E
D
L
-----
G
-----
D
K
G
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
E
-
I
--
H
K
-
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
--------
99
PsiBlast_CBE
58.35
34%
15
- C6 -
-
3L0G
2
?
B:
[33-292]
----------------------------
A
L
K
E
D
L
-----
G
-----
D
K
G
D
I
T
T
N
S
I
----
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
N
M
N
---
K
E
-
H
V
K
Y
E
-
I
--
H
K
-
K
D
G
D
I
T
G
-----
K
N
S
------
T
L
V
-
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
--
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
-
I
S
E
I
K
K
A
V
D
I
V
N
----
G
K
---
S
---
V
---
L
--
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
--------
106
PsiBlast_CBE
57.37
35%
-35
- C6 -
-
3C2V
2
NADC_YEAST
A:
[21-291]
-----------------------------
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
S
D
L
K
E
A
--
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
---
E
L
-
Q
V
E
W
L
------
F
K
E
G
S
F
L
E
PSKND
S
G
K
------
I
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
--
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-----------------------------H
F
L
L
--
E
C
S
G
G
L
N
L
D
N
L
--
Y
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
-------
134
HHSearch
56.76
35%
-32
- C6 -
-
3C2V
2
NADC_YEAST
A:
[13-293]
---------------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
-
S
D
-
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
------
E
L
Q
V
--
E
--
W
L
F
K
E
G
S
F
L
E
-----
P
S
K
NDSGKI
V
V
A
-
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
G
T
--
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
--------------------
H
---
F
---
L
---
L
--
E
C
S
G
G
L
N
L
D
N
L
--
Y
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
A
-----
108
PsiBlast_CBE
55.88
35%
-17
- C6 -
-
3C2F
1
NADC_YEAST
A:
[21-291]
-----------------------------
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
S
D
L
K
E
A
--
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
---
E
L
-
Q
V
E
W
L
------
F
K
E
G
S
F
L
E
PSKND
S
G
K
------
I
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
--
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-----------------------------H
F
L
L
--
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
-------
107
PsiBlast_CBE
55.83
35%
-27
- C6 -
-
3C2O
1
NADC_YEAST
A:
[21-291]
-----------------------------
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
S
D
L
K
E
A
--
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
---
E
L
-
Q
V
E
W
L
------
F
K
E
G
S
F
L
E
PSKND
S
G
K
------
I
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
--
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-----------------------------H
F
L
L
--
E
C
S
G
G
L
N
-------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
-------
105
PsiBlast_CBE
55.69
35%
-17
- C6 -
-
3C2R
2
NADC_YEAST
A:
[22-292]
-----------------------------
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
S
D
L
K
E
A
--
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
---
E
L
-
Q
V
E
W
L
------
F
K
E
G
S
F
L
E
PSKND
S
G
K
------
I
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
--
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-----------------------------H
F
L
L
--
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
-------
104
PsiBlast_CBE
54.93
35%
-22
- C6 -
-
3C2R
2
NADC_YEAST
B:
[22-292]
-----------------------------
L
S
E
D
V
-----
P
-----
S
F
-
D
F
G
G
Y
V
V
----
G
S
D
L
K
E
A
--
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
N
Q
C
---
E
L
-
Q
V
E
W
L
------
F
K
E
G
S
F
L
E
PSKND
S
G
K
------
I
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
--
S
T
G
Y
K
GT
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-----------------------------HFL
L
--
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
-------