@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMH8: (2017-11-08 )
MLNSEFQPNWLYPPSEVIKNFIQLNNIDTSAFDVSTKKIIDDLVNQNTKIDLYTSEVLKEAIGGTTQFWLNIQNQFTINSLRIQNSSVDNNFSEYRNLVNELKKLHWTPESKYDYLDQINLKSFFGISEFSLLTKKYIVQHNLRVKFKNIGQYNSSELNVATLIRKAELEAKKQPILSPWNKLLFIEKLQEIKKLSKVKGFKNFRNELLSICNQCGVAFIVLDTLNKSPIRGISKFLDSNIGLIIVTTKYNKDDVFWQTFFHEAGHLVLHSKEMVFSDQGDLNKEASHNLEEAQADEFMLTHILHPYTIEEVTNMFNTRIMYKSKTESWRNICQIARQVNISPSLLTGILKFQGIIPYSYFTNGHEKLYD
Atome Classification :
(20 SA)
--------....--------.....10.......----.20....-....30.----------..---.---..---..40.------------.......50-------....---------....------60----..--------------..---------------..-------.--------.70------.......----..80..------...--...90..------......100---....-------.-------------------------------....110-----..--------..---.....--120...--...--.130-------.....-----..----------140-.....--------....150.-------.-----------------------...--------.-.160......-.-------.170---......-.180----..--......--190---....----.--...200.--....--------..210-----..----------------------.-....220--------.--------.-----------...---..230.-....---..240.--------......250......-----..260---......--..270-........-.--280-.......290-------.-.......300.....----..310..--------...--..320.--......330..-------..-----...340--------------....-----....350..----.....360........370----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MLNS--------EFQPNWLY
P
P
S
E
V
I
----
K
N
F
I
Q
LN-NIDTSAF----------D
V
---
S
---
T
K
---
K
I
I
D
D
------------
L
VNQNT
K
I
D
-------
L
Y
T
S
---------
E
V
L
K
------
E
A----IG--------------GT---------------
T
Q
-------
F
--------
W
L
-------
N
IQ
N
Q
F
T
----
I
N
S
L
R
I
------QNS--SVDN
N
F
S
------
E
Y
R
N
L
V
N
-----
E
L
K
K
-------L-------------------------------HWTPE-------SK--------Y
D
---
Y
L
D
QI--
N
L
K
S
FF--G
I
S
--
E
F
S
L
-------
L
T
K
K
Y
-----
I
V
----------Q---HN
L
R
V
--------
K
F
KNIGQY-------N-----------------------SSE--------
L
-
N
V
-
A
T
L
I
R
K
A
-
E
-------LEAK---KQPIL
S
-
P
W
N
-----
K
L
--
L
F
I
E
K
L
--
Q
E
----
I
K
K
L
----
S
--
K
V
K
G
F
K
N
--
F
R
N
E
--------
L
L
S
I
C
-----
N
Q----------------------C-
G
V
A
F
I
V
L
--------D--------T-----------LNK---S
P
I
R
G
I
-
S
K
F
L
---DSNI
G
L
--------
I
I
V
T
T
KYN-KD
D
V
F
W
-----
Q
T
F
F
----HEAG
H
L
--
V
L
H---SK
E
M
V
FSD-Q--GDL-N
K
E
ASHN
L
E
--------
E
-
A
Q
A
D
E
F
M
L
T
H
ILHPY----
T
I
E
E
V
T
N
--------
M
FN--
T
R
I
M
Y
K--S
K
T
E
S
W
R
N
I
C
Q
-------
I
A
-----
R
QVNI---------------
S
P
S
L
-----
L
T
G
I
L
K
FQG----II
P
Y
SYF-TNG
H
E
KLYD------------------------
49
Fugue
58.65
16%
24
- C1 -
-
2CY7
-
ATG4B_HUMAN
A:
[5-377]
--------
T
L
T
Y
DTL-----
R
F
A
E
F
E
D
F
P
E
T
S
-------
E
P
V
W
I
L
-
G
R
K
Y
S
I
F
----------
T
----
E
---
K
D
---
E
I
L
S
D
------------
V
A
S
R
L
-----------
W
F
T
Y
---------
R
K
N
F
------
P
A
----
I
G
--------------
G
T
---------------
G
P
TSDTGWG
C
--------
M
L
-------
R
C
G
Q
M
I
F
----
A
Q
A
L
V
C
------
R
H
L
--
G
R
D
W
R
W
T
------
Q
R
K
R
-----------------------------------------------------
Q
P
D
-------
S
Y
--------
F
S
---
V
L
N
A
F
ID
R
K
D
S
Y
Y
--
S
I
H
--
Q
I
A
Q
-------
M
G
V
G
-----------------------------------
E
G
K
S
I
G
Q
W
-------
Y
-----------------------
G
P
N
--------
T
-
V
A
-
Q
V
L
K
K
L
A
-
V
-------
F
D
T
W
---
S
S
L
A
V
H
I
A
M
D
-----
N
T
--
V
V
M
E
E
I
--
R
R
----
L
C
R
T
----
S
--
V
--
P
C
S
P
--
W
R
P
L
--------
V
L
L
I
P
-----
L
R
----------------------
L
-
G
-----
L
--------
T
--------
D
-----------
I
N
E
---
A
Y
V
E
T
L
-
K
H
C
F
---
M
M
P
Q
S
L
--------
G
V
I
G
G
K
P
N
-
S
A
H
Y
F
I
-----
G
Y
V
G
----
E
E
L
I
Y
L
--
D
P
H
---
T
----------------
T
Q
P
A
V
E
G
C
--------
F
-
I
P
D
E
S
F
H
C
Q
H
P
P
C
R
M
----
S
I
A
E
L
D
P
--------
S
I
A
--
V
G
F
F
C
K
--
T
-
E
D
D
F
N
D
W
C
Q
-------
Q
V
-----
K
K
L
S
L
---------------
L
P
-
M
-----
F
E
L
V
E
Q
Q
P
D
----
V
L
N
L
S
L
D
-
S
S
D
V
E
R
L
--------------------------
3
PsiBlast_PDB
56.01
23%
31
- C9 -
-
5V38
4
?
A:
[36-381]
------------------------------
S
E
I
D
----
K
N
Q
V
Q
L
S
-
N
L
E
S
S
K
I
----------
E
V
-------------
I
L
N
N
------------
G
V
I
Y
N
S
M
Y
E
-------
N
F
--------------------------------------------
S
---------------
T
S
-------
F
--------
W
I
R
I
P
KYFR
N
I
N
N
E
Y
K
----
I
I
S
C
M
Q
------
N
N
S
G
W
E
V
S
L
N
F
S
------------
N
-----
M
N
S
K
-------
I
-------------------------------
I
W
T
L
Q
-------
D
T
EG
I
K
K
T
V
V
F
Q
---
Y
T
Q
N
I
--
N
I
S
D
Y
I
--
N
R
W
--
I
F
V
T
-------
I
T
N
N
R
-----
L
S
----------
N
---
S
K
I
Y
I
--------
N
G
R
L
I
N
E
E
-------
S
-----------------------
I
S
D
--------
L
G
N
I
H
A
S
N
N
I
M
F
-
K
-------
L
D
G
C
---
R
D
P
H
R
Y
-
I
W
I
-----
K
Y
F
N
L
F
D
K
E
L
N
K
K
E
----
I
K
D
L
Y
D
N
Q
S
--
N
S
G
I
L
K
D
--
F
W
G
D
--------
Y
L
---------
Q
----------------------
Y
-
D
K
P
Y
Y
M
L
--------
N
LYDPN
K
Y
L
D
-----------
V
N
N
---
V
G
I
R
G
Y
--
M
Y
L
---
K
G
P
R
G
R
--------
I
V
T
T
N
I
Y
L
-
N
S
T
L
Y
M
-----
G
T
K
F
I
I
K
K
Y
A
S
G
N
K
DN
I
V
R
---
N
N
D
R
V
Y
I
N
-
V
--
V
V
K
-
N
K
E
Y
R
L
A
T
N
--------
A
-
S
Q
A
G
---
V
E
K
I
L
S
A
V
----
E
I
P
D
V
G
N
--------
L
S
Q
--
V
V
V
M
K
S
--
E
N
D
Q
G
I
R
N
K
C
K
-------
M
N
-----
L
Q
D
N
-------------------------------------------------------------------------------
46
Fugue
54.99
18%
10
- C- -
-
3GRE
-
VPS15_YEAST
A:
[1031-1454]
--------
E
S
I
E
--------
K
F
L
S
T
F
I
L
P
P
L
R
D
Y
----
K
E
F
G
P
I
Q
-
E
I
V
R
S
P
N
----------
M
G
---
N
---
L
R
---
G
K
L
I
A
------------
T
L
M
E
N
E
P
N
S
-------
I
T
S
S
---------
A
V
S
P
------
G
E
T
P
Y
L
I
T
--------------
G
S
---------------
D
Q
-------
G
--------
V
I
-------
K
I
W
N
L
K
E
----
I
I
V
G
E
V
------
Y
S
S
--
S
L
T
Y
D
C
S
------
S
T
V
T
Q
I
T
-----
M
I
P
N
-------
F
D------------------------------
A
F
A
V
S
-------
S
K
--------
D
G
---
Q
I
I
V
L
--
K
V
N
H
Y
Q
--
Q
E
S
--
E
V
K
F
-------
L
N
C
E
C
-----
I
R
----------
K
---
I
N
L
K
N
--------
F
G
K
N
E
-----------------------------------------------
Y
A
-
V
R
M
R
A
F
V
-
N
-------
E
E
K
S
---
L
L
V
A
L
T
-
N
L
S
-----
R
V
--
I
I
F
D
----------
I
R
T
L
----
E
--
R
L
Q
I
I
E
N
S
P
R
H
G
A
--------
V
S
S
I
C
I
D
---
E
E
----------------------
C
-
C
V
L
I
L
G
T
TRG
I
I
D
I
W
D
--------
I
-----------
R
F
N
---
V
L
I
R
S
W
-
S
F
G
D
---
H
A
P
I
T
H
--------
V
E
V
C
Q
F
Y
G
-
K
N
S
V
I
V
V
G
GSS
K
T
F
L
----
T
I
W
N
F
V
--
K
G
H
---
C
Q
Y
A
F
I
N
S
-
D
--
E
Q
P
-
S
M
E
H
F
L
P
I
E
--------
K
G
L
E
E
L
N
F
C
G
I
R
S
L
N
A
L
----
S
T
I
S
V
S
N
D
K
I
L
L
T
D
E
A
T
S
--
S
I
V
M
F
S
--
L
N
E
L
S
S
S
K
A
V
I
SPF
S
D
V
F
I
P
-----
T
Q
V
T
A
---------------
N
L
T
M
-----
L
L
R
K
M
K
H
D
I
----
I
N
S
I
S
T
C
-
E
V
D
E
T
P
L
L
V
A
C
D
NSG
L
I
G
I
F
Q------------
50
Fugue
52.20
16%
-44
- C5 -
-
5K47
3
PKD2_HUMAN
A:
[30-519]
--RE
K
Y
L
K
S
V
L
R
--------
E
L
V
T
Y
L
L
F
L
I
V
L
C
I
----
L
T
Y
G
M
M
S
-
S
N
V
Y
Y
Y
T
----------
R
M
---
M
---
S
Q
---
L
F
L
D
T
------------
P
V
S
K
T
E
K
T
N
-------
F
K
T
L
---------
S
S
M
E
------
D
F
----
W
K
--------------
F
T
E
G
S
L
L
D
G
L
Y
WKMQPD
N
R
-------
S
--------
F
I
-------
F
Y
E
N
L
L
L
G
V
P
R
I
R
Q
L
R
V
------
R
N
G
--
S
C
S
I
P
-
Q
------
D
L
R
D
E
I
K
-----
E
C
Y
D
-------
V
Y
SVSSEDRAPFGPRNGTAW
I
Y
T
S
EKDLN
G
S
S
H
W
G
I
I
-------
A
T
--------
Y
S
G
A
G
Y
Y
L
D
L
--
S
R
T
R
E
E
--
T
A
A
--
Q
V
A
S
-------
L
K
K
N
V
-----
W
L
----------
D
---
R
G
T
R
A
--------
T
F
I
D
F
S
V
Y
-------
N
ANIN
L
F
C
V
V
R
L
L
V
E
F
P
AT
G
G
V
I
P
S
W
Q
--------
F
-
Q
P
-
L
K
L
I
R
Y
V
T
T
-------
F
D
F
F
---
L
A
A
C
E
I
-
I
F
C
-----
F
F
--
I
F
Y
Y
V
V
--
E
E
----
I
L
E
I
----
R
I
H
K
L
H
Y
F
R
S
--
F
W
N
C
--------
L
D
V
V
I
-----
V
V
----------------------
L
-
S
V
V
A
I
G
I
--------
N
--------
I
-----------
Y
R
T
---
S
N
V
E
V
L
-
L
Q
F
L
---
E
D
Q
--------------
N
T
F
P
N
F
E
H
L
A
Y
W
-----
Q
I
Q
F
----
N
N
I
A
A
V
--
T
V
F
F
V
W
I
K
L
F
K
F
I
N
-
F
--
N
R
T
-
M
S
Q
L
S
T
T
M
S
--------
R
-
C
A
K
D
L
F
G
F
A
I
M
F
F
I
I
----
F
L
A
Y
A
Q
L
--------
A
Y
L
--
V
F
G
T
Q
V
--
D
D
F
S
T
F
Q
E
C
I
F
-------
T
Q
-----
F
R
I
I
L
GDIN
F
A
E
I
E
E
A
NRVL
G
P
I
Y
-----
F
T
T
F
V
F
F
M
F
----
F
I
L
L
N
M
F
-
L
A
I
I
N
D
T
Y
S
E
V
K
S
D
L
A
Q
Q
K
A
E
M
E
L
S
D-------
47
Fugue
50.46
20%
38
- C3 -
-
2I3O
-
?
D:
[2-516]
-----FRS
R
P
N
A
--------
L
S
Q
R
S
V
I
A
S
S
S
E
L
A
SLAG
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
----------
A
V
---
S
---
A
L
---
C
V
T
Q
N
NLCGLGGDLFAL
I
R
D
E
N
G
Q
I
D
-------
L
N
G
S
GQASRAVSI
D
Y
Y
E
------
S
G
----
L
T
KIPERGPYAAITVP
G
I
---------------
A
G
-------
S
--------
W
D
-------
E
I
F
R
K
F
A
----
T
D
I
A
D
I
------
L
E
P
--
A
I
R
T
A
S
A
GFPITQ
N
Y
S
D
S
I
A
-----
R
S
A
P
-------
V
IGQYR--------------------------
G
W
S
S
I
FPNGSVP
V
A
--------
G
E
---
I
L
K
Q
P
--
D
L
A
E
S
F
--
R
L
S
--
E
E
G
F
RSFYDGS
L
A
D
I
I
-----
I
A
GLEGTGSPLS
D
---
R
D
L
R
V
YRPLIGKP
V
F
T
D
L
D
E
F
RIYETSP
N
-----------------------
S
Q
G
--------
I
-
T
V
-
I
E
W
I
R
G
E
-
S
HGYDSRT
W
E
A
K
---
I
E
D
I
F
E
-
T
E
E
-----
A
Y
--
D
K
R
R
K
I
--
T
D
PSYN
I
A
Q
H
----
D
--
S
A
N
G
K
G
L
--
P
K
R
D
HNDIGDTT
Y
F
S
I
S
-----
D
S
----------------------
E
-
G
R
S
V
S
I
I
--------
Q
--------
S
-----------
N
Y
G
FGS
G
I
V
P
K
G
-
T
G
F
V
---
L
Q
N
R
G
S
--------
Y
F
T
L
Q
R
D
H
-
P
N
A
L
P
G
-----
K
R
T
F
----
H
T
L
A
A
C
--
V
E
K
---
E
H
D
L
Y
A
S
L
-
G
SG
G
D
I
-
Q
P
Q
V
Q
Q
I
L
E
ILKDNTDP
Q
-
A
I
L
D
K
---
P
R
W
T
E
P
Y
----
T
I
Y
E
A
P
G
--------
A
V
Y
VE
S
E
E
L
Y
R
NV
S
K
Q
I
S
G
R
K
V
V
L
-------
R
D
-----
V
S
Q
E
F
---------------
G
T
A
Q
-----
I
T
T
L
I
R
G
D
V
----
V
V
G
A
A
D
P
R
G
D
G
I
A
I
P
Y
S
------------------------
11
PsiBlast_PDB
46.68
35%
-298
- C8 -
-
2NV9
-
?
A:
[2-36]
------------------------------
N
S
V
V
----
N
N
I
L
K
A
H
-
P
H
Q
T
K
S
F
----------
Y
V
---
S
---
S
P
---
K
I
V
E
D
------------
L
I
D
Q
W
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
46.65
18%
16
- C2 -
-
3J9O
-
?
B:
[79-505]
V
I
D
K
L
I
D
L
Q
V
N
S
I
I
S
ND
E
F
R
A
L
E
Q
E
W
L
K
V
Q
E
V
C
Q
----
E
D
Y
---
D
-
N
V
E
V
S
I
L
----------
D
V
---
K
---
K
E
---
E
L
Q
Y
D
------------
F
E
R
N
L
Y
D
I
S
SS
D
F
F
K
K
V
Y
V
S
---------
E
F
D
Q
YG
G
E
P
Y
G
A
----
I
L
--------------
G
L
---------------
Y
N
-------
F
E
NT
T
N
D
I
I
W
L
-------
T
G
M
G
M
V
A
----
K
N
S
H
A
P
------
F
I
A
--
S
I
D
K
S
F
F
------
G
V
K
D
L
S
E
ITHIK
S
F
E
A
-------
L
-------------------------------
L
E
H
P
R
Y------
K
E
--------
W
N
---
D
F
R
N
L
--
D
V
A
A
Y
I
--
G
L
T
V
G
D
F
-
M
-------
L
R
Q
P
Y
NPENN
P
V
----------
Q
---
Y
K
L
M
E
--------
G
F
N
E
F
V
D
Y
-------
D
-----------------------
K
N
E
-------------
S
Y
L
W
G
P
A
-
S
-------
I
H
L
V
---
K
N
M
M
R
S
--
Y
D
-----
K
T
--
R
W
F
Q
Y
I
--
R
G
----
V
E
S
G
----
G
--
Y
V
K
N
L
V
A
--
C
V
Y
D
--------
N
K
G
I
L
-----
E
T
----------------------
K
-
S
P
L
N
V
L
F
--------
A
--------
D
-----------
Y
M
E
---
L
S
L
A
------------
N
I
G
L
--------
I
P
F
V
S
E
K
G
-
T
S
N
A
C
F
-----
F
S
V
------
N
S
A
K
K
--
V
E
E
---
F
V
D
G
F
D
S
A
-
N
--
S
R
L
-
I
A
N
L
S
Y
T
M
C
--------
I
-
S
R
I
S
H
Y
I
K
C
V
I
R
D
K
I
GSIV
D
V
E
S
I
Q
K
--------
I
L
S
--
D
W
I
S
E
F
--
V
T
T
V
Y
Q
P
T
P
L
E
-------
M
A
RYPF-
R
N
V
S
I
---------------
E
V
K
T
-----
I
P
G
K
P
G
W
Y
S
C
K
I
N
V
I
P
H
I
Q
F
-
E
G
M
N
T
T
M
T
I
DTRLEPELFGTNN-----------
12
PsiBlast_PDB
44.77
35%
-298
- C8 -
-
2NVA
-
?
A:
[2-38]
------------------------------
N
S
V
V
----
N
N
I
L
K
A
H
-
P
H
Q
T
K
S
F
----------
Y
V
---
S
---
S
P
---
K
I
V
E
D
------------
L
I
D
Q
W
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
43.49
15%
-31
- C8 -
-
3DTE
-
IRRE_DEIDV
A:
[10-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
L
A
--
A
A
K
A
R
M
--
R
E
----
L
A
A
S
----
Y
--
G
A
G
--
L
---
P
G
R
D
--------
T
H
S
L
M
-----
H
G
----------------------
L
D
G
I
T
L
T
F
M
--------
P
--------
M
-----------
G
------
Q
R
D
G
A
-
Y
--
D
---
P
-
E
H
H
V
--------
I
L
I
N
S
Q
-
V
-
R
P
E
R
Q
R
-----
F
T
L
A
----
H
E
I
S
H
A
--
L
L
L
---
G
D
D
D
L
L
S
D
-
L
--
H
D
E
Y
E
G
D
R
L
E
Q
V
I
--------
E
-
T
L
C
N
V
G
A
A
A
-
L
L
M
P
A
----
E
L
I
D
-----------
D
L
L
--
T
R
-------
F
G
P
T
G
R
A
L
A
E
-------
L
A
-----
R
R
A
D
V
---------------
S
A
T
S
-----
A
L
Y
A
L
A
E
R
T
----
A
----------------------------------------
48
Fugue
43.17
12%
22
- C7 -
-
5LB8
-
RECQ5_HUMAN
D:
[4-444]
-----PER
R
V
R
S
--------
T
L
K
K
V
F
G
F
D
S
F
K
T
P
----
L
Q
E
S
A
T
M
-
A
V
V
K
G
N
K
----------
D
V
---
F
---
V
C
---
M
P
T
G
A
------------
G
K
S
L
C
Y
Q
L
P
-------
A
L
L
A
---------
K
G
I
T
------
I
V
----
V
S
--------------
P
L
---------------
I
A
-------
L
--------
I
Q
-------
D
Q
V
D
H
L
L
----
T
L
K
V
R
V
------
S
S
L
--
N
S
K
L
S
A
Q
------
E
R
K
E
L
L
A
-----
D
L
E
R
EKPQTKI
L
-------------------------------
Y
I
T
P
E
-------
M
A
--------
A
S
---
S
S
F
Q
P
--
T
L
N
S
L
V
SR
H
L
L
--
S
Y
L
V
-------
V
D
E
A
H
-----
C
V
----------
S
QWG
H
D
F
R
P
--------
D
Y
L
R
L
G
A
L
-------
R
-----------------------
S
R
L
GHAPCVAL
T
-
A
T
-
A
T
P
Q
V
Q
E
-
D
-------
V
F
A
A
LHL
K
K
P
V
A
I
-
F
K
T
PCFRA
N
L
--
F
Y
D
V
Q
F
--
K
E
----
L
I
S
-----
D
--
P
Y
G
N
L
K
D
--
F
C
L
K
--------
A
C
G
I
V
YCRTR
E
A
----------------------
C
-
E
Q
L
A
I
E
L
--------
S
--------
C
RGVNAKAYHAG
L
K
A
---
S
E
R
T
L
V
Q
N
D
W
M
---
E
E
K
V
P
V
--------
I
V
A
T
I
S
F
D
-
K
A
N
V
R
F
-----
V
A
H
W
----
N
I
A
K
S
M
--
A
G
Y
---
Y
Q
E
S
G
R
A
-----
G
R
D
-
G
K
P
S
W
C
R
L
Y
--------
Y
-
S
R
N
D
R
D
Q
V
S
F
L
I
R
K
-----
E
V
A
K
L
Q
E
--------
K
R
G
--
N
K
A
S
D
K
--
A
T
I
M
A
F
D
A
L
V
T
-------
F
C
EELGC
R
H
A
A
I
---------------
A
K
Y
F
-----
G
D
A
L
P
A
C
A
K
----
G
C
D
H
C
Q
N
-
P
T
A
V
R
R
R
L
E
ALERSSS-----------------
30
HHSearch
41.91
7%
-72
- C8 -
-
3KZ3
-
RPC1_LAMBD
B:
[17-80]
-----------------------------
L
K
A
I
W
----
E
K
K
K
N
E
L
-
G
L
S
Y
E
S
V
----------
A
D
---
K
---
M
G
MGQ
S
A
V
A
A
------------
L
F
N
G
I
N
A
L
N
-------
A
Y
N
A
---------
A
L
L
A
------
K
I
----
L
K
--------------
V
S
---------------
V
E
-------
E
--------
F
S
-------
P
S
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
41.44
15%
-31
- C8 -
-
3DTK
-
IRRE_DEIDV
A:
[30-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
L
A
--
A
A
K
A
R
M
--
R
E
----
L
A
A
S
----
Y
--
G
A
G
--
L
---
P
G
R
D
--------
T
H
S
L
M
-----
H
G
----------------------
L
D
G
I
T
L
T
F
M
--------
P
--------
M
-----------
G
------
Q
R
D
G
A
-
Y
--
D
---
P
-
E
H
H
V
--------
I
L
I
N
S
Q
-
V
-
R
P
E
R
Q
R
-----
F
T
L
A
----
H
E
I
S
H
A
--
L
L
L
---
G
D
D
D
L
L
S
D
-
L
--
H
D
E
Y
E
G
D
R
L
E
Q
V
I
--------
E
-
T
L
C
N
V
G
A
A
A
-
L
L
M
P
A
----
E
L
I
D
-----------
D
L
L
--
T
R
-------
F
G
P
T
G
R
A
L
A
E
-------
L
A
-----
R
R
A
D
V
---------------
S
A
T
S
-----
A
L
Y
A
L
A
E
R
T
----
A
----------------------------------------
5
PsiBlast_PDB
39.87
47%
-152
- C- -
-
3DVW
-
?
A:
[110-143]
---------------------------------------------------------------
D
V
---
A
---
N
S
---
H
I
F
D
A
------------
M
V
N
Q
--
K
I
K
-------
L
Q
N
P
---------
E
V
L
K
------
K
W
----
L
G
--------------
E
Q
---------------
T
A
-------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
39.10
14%
-20
- C8 -
-
2EBY
-
YBAQ_ECOLI
A:
[7-108]
------------------------
K
P
T
T
P
G
D
I
L
L
----
Y
E
Y
L
E
P
L
-
D
L
K
I
N
E
L
----------
A
E
---
L
L
HV
H
R
---
N
S
V
S
A
------------
L
I
N
N
N
R
K
L
T
-------
T
E
M
A
---------
F
R
L
A
------
K
V
----
F
D
--------------
T
T
---------------
V
D
-------
F
--------
W
L
-------
N
L
Q
A
A
V
D
----
L
W
E
V
E
-------
N
N
M
--
R
T
Q
E
E
L
G
------
R
I
E
T
V
A
E
-----
Y
L
A
R
-------
R
-------------------------------
E
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
36.78
15%
25
- C4 -
-
4MT0
-
?
A:
[1-445]
-----------
C
--------
T
M
I
P
Q
Y
E
Q
P
K
V
E
V
A
----
E
T
F
Q
N
D
T
-
S
V
S
S
I
R
A
VDLG
W
H
D
Y
F
A
D
P
---
R
---
L
Q
---
K
L
I
D
I
------------
A
L
E
R
N
T
S
L
R
T
A
-----
V
L
N
S
---------
E
I
Y
R
------
K
Q
----
Y
M
--------------
I
E
---------------
R
N
-------
N
--------
L
L
-------
P
T
L
A
A
N
A
----
N
G
S
R
Q
G
S
LSG
G
N
V
S
S
--
S
Y
N
V
G
L
G
------
A
A
S
Y
E
L
D
-----
L
F
G
R
-------
V
-------------------------------
R
S
S
S
E
-------
A
A
--------
L
Q
G
--
Y
F
A
S
V
--
A
N
R
D
A
A
--
H
L
S
--
L
I
A
T
-------
V
A
K
A
Y
-----
F
N
----------
E
---
R
Y
A
E
E
--------
A
M
S
L
A
Q
R
V
-------
L
-----------------------
K
T
R
--------
E
-
E
T
-
Y
N
A
V
R
I
A
---------
V
Q
G
R
---
R
D
F
R
R
R
-
P
A
P
-----
A
E
--
A
L
I
E
S
A
--
K
A
----
D
Y
A
H
----
A
--
A
-
R
S
R
E
Q
--
A
R
N
A
--------
L
A
T
L
I
-----
N
R
PIPEDLPAGLPLDKQFFV
E
K
L
P
A
-
G
L
S
S
E
V
L
-----------------------------
L
D
R
---
P
D
I
R
A
A
-
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
R
L
T
G
S
V
G
-
T
G
S
V
E
L
-----
G
G
L
F
----
K
S
G
T
G
V
--
W
A
F
---
A
P
S
I
T
L
P
I
F
T
--
W
G
T
-
N
K
A
N
L
D
V
A
K
--------
L
-
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
----
A
F
Q
D
V
A
N
--------
A
L
A
--
A
R
E
Q
L
D
--
K
A
Y
D
A
L
S
K
Q
S
R
-------
A
S
-----
K
E
A
L
R
---------------
L
V
G
L
R
Y
K
HG
V
S
G
A
L
D
L
L
D
----
A
E
R
S
S
Y
S
-
A
E
G
A
A
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
GGGLKRDTQT
29
HHSearch
36.46
11%
-51
- C8 -
-
4I6R
3
?
A:
[9-75]
--------------------------
L
S
K
V
S
F
V
I
----
K
K
I
R
L
E
K
-
G
M
T
Q
E
D
L
----------
A
Y
---
K
---
S
N
LD
R
T
Y
I
S
G
------------
I
E
R
N
S
R
N
L
T
-------
I
K
S
L
---------
E
L
I
M
------
K
G
----
L
E
--------------
V
S
---------------
D
V
-------
V
--------
F
F
-------
E
M
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
36.01
26%
-13
- C8 -
-
3CEC
2
?
A:
[19-83]
-----------------------------
P
G
E
V
I
----
A
D
I
L
D
D
L
-
D
I
N
T
A
N
F
----------
A
E
I
L
G
V
---
S
N
---
Q
T
I
Q
E
------------
V
I
N
G
Q
R
S
I
T
-------
V
D
I
A
---------
I
R
L
G
------
K
A
----
L
G
--------------
N
G
---------------
P
R
-------
L
--------
W
L
-------
N
L
Q
Q
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
35.96
15%
-7
- C8 -
-
1ADR
-
RPC2_BPP22
A:
[5-69]
----------------------------
L
M
G
E
R
I
----
R
A
R
R
K
K
L
-
K
I
R
Q
A
A
L
----------
G
K
---
M
---
V
G
VS
N
V
A
I
S
Q
------------
W
E
R
S
E
T
E
P
N
-------
G
E
N
L
---------
L
A
L
S
------
K
A
----
L
Q
--------------
C
S
---------------
P
D
-------
Y
--------
L
L
-------
K
G
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
35.31
11%
-34
- C8 -
-
4I6U
2
?
A:
[9-75]
--------------------------
L
S
K
V
S
F
V
I
----
K
K
I
R
L
E
K
-
G
M
T
Q
E
D
L
----------
A
Y
---
K
---
S
N
LD
R
T
F
I
S
G
------------
I
E
R
N
S
R
N
L
T
-------
I
K
S
L
---------
E
L
I
M
------
K
G
----
L
E
--------------
V
S
---------------
D
V
-------
V
--------
F
F
-------
E
M
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
35.21
10%
-39
- C8 -
-
1LLI
2
RPC1_LAMBD
B:
[26-80]
-----------------------------------------
K
N
E
L
-
G
L
S
Q
E
S
L
----------
A
D
---
K
---
L
G
MG
Q
S
G
I
G
A
------------
L
F
N
G
I
N
A
L
N
-------
A
Y
N
A
---------
A
L
L
A
------
K
I
----
L
K
--------------
V
S
---------------
V
E
-------
E
--------
F
S
-------
P
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------