@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMS4: (2017-11-10 )
MTTLTCFKAYDIRGKLGTELNEEIAYKIGRAYGQIYKPKTVVVGCDIRLSSEALKQAAIRGLNDAGVNVLDLGMTGTEEVYFAAFHLDVQGGIEVTASHNPMDYNGMKLVRENARPISADTGLKEIQALAETNNFEEVGQKGTTQSYNILPEFVDHLLTYIEPAKIRPLKLVVNAGNGAAGHVIDAIEEKFKALNVPVEFIKIHHEADGTFPNGIPNPILIENRDSTRNAVLEHKADMGIAWDGDFDRCFLFDEKGQFIEGYYIVGLLAQAFLIKQSGEKIVHDPRLVWNTFDIVDEYKGVTVQSKSGHAFIKDVMREHNAVYGGEMSAHHYFRDFAYCDSGMIPWLLTIVLLSETGQSLSTLVENMIAKFPCSGEINFKVADTQTTIQKIFDFYADQNPQIDRTDGVSLNFGAWRFNVRASNTEPLLRLNIESRADRQAQPMQYYVDELTGLIQN
Atome Classification :
(22 SA)
---.........10........20........30......-----..---40........50........60........70........80.....--------...90........100.......110.......120...-....130......--.--140.-.....-..150.......160..--.--....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.....--..-280.......290.......300.......310.......320.......330...--.-.-.-.340.......350.......360.......370---.-......380-.-.--.....390......-.400........410.......420.......430......-.440.......450....------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
T
T
L
T
C
F
K
A
Y
DIRGKLGT
E
L
N
E
E
I
A
Y
K
I
G
R
A
YGQIYK-----
P
K
---
T
V
V
V
G
C
D
I
R
L
S
S
E
A
L
K
Q
A
A
IRGLNDAG
V
N
V
L
D
LGMTGT
E
E
V
Y
F
A
A
F
H
--------
L
D
VQG
G
I
E
V
TASHNPMDYN
G
M
K
L
V
R
ENARPISADT
G
L
K
E
-
I
Q
A
L
A
ETN
N
F
E
E
V--G--QK-G-TTQSY-NI
L
P
E
F
V
D
H
L
L
T
YIEPA--K--
I
R
P
L
K
L
V
V
NAGNGAA
G
H
V
I
D
A
I
E
E
K
F
K
A
LNVP
V
E
F
I
K
I
H
HEADGTFPNGIPN
P
I
L
I
ENRDS
T
R
N
A
V
L
E
HKADM
G
I
A
WDGDF
D
R
C
F
L
FDEKG
Q
F
I
E
G
Y
Y
I
V
G
L
L
A
Q
A
F
L
I
KQS--GE-KIVHDP
R
L
V
W
N
T
F
D
I
V
D
EYK
G
V
T
V
QSKSG
H
A
F
I
K
D
V
M
R
EHNAVYGGE
M
S
A
H
H
Y
F
R
D
--
F
-
A
-
Y
-
C
DSG
M
I
P
W
L
L
T
I
V
L
L
SETG
Q
S
L
S
T
L
V
E
N
M
I
A
KFP---C-S
G
E
I
N
F
K
VA-
D
-
T
--
Q
T
T
I
Q
K
I
F
D
F
YADQ-NP-QIDRTDG
V
S
L
N
F
G
A
W
R
F
N
V
RASNTE
P
L
L
R
L
NIESRADR-QA
Q
P
M
Q
Y
Y
V
D
E
L
T
G
L
IQN------
2
PsiBlast_PDB
99.66
55%
-89
- C1 -
-
5BMN
-
?
A:
[22-467]
-----
T
L
P
A
F
K
A
Y
D
I
R
G
R
V
P
D
E
L
N
E
D
L
A
R
R
I
G
V
A
L
A
A
Q
L
D
-----
Q
G
---
P
V
V
L
G
H
D
V
R
L
A
S
P
A
L
Q
E
A
L
S
A
G
L
R
A
S
G
R
D
V
I
D
I
G
L
C
G
T
E
E
V
Y
F
Q
T
D
Y
--------
L
K
A
A
G
G
V
M
V
T
A
S
H
N
P
M
D
Y
N
G
M
K
L
V
R
E
Q
A
R
P
I
S
S
D
T
G
L
F
A
-
I
R
D
T
V
A
A
D
T
A
A
P
G
--
E
--
P
T
-
A
-
S
E
Q
S
R
-
T
D
K
T
A
Y
L
E
H
L
L
S
Y
V
D
R
S
--
T
--
L
K
P
L
K
L
V
V
N
A
G
N
G
G
A
G
L
I
V
D
L
L
-----
A
P
H
L
P
F
E
F
V
R
V
F
H
E
P
D
G
N
F
P
N
G
I
P
N
P
L
L
P
E
N
R
D
A
T
A
K
A
V
K
D
N
G
A
D
F
G
I
A
W
D
G
D
F
D
R
C
F
F
F
D
H
T
G
R
F
I
E
G
Y
Y
L
V
G
L
L
A
Q
A
I
L
A
K
Q
P
--
G
G
-
K
V
V
H
D
P
R
L
T
W
N
T
V
E
Q
V
E
E
A
G
G
I
P
V
L
C
K
S
G
H
A
F
I
K
E
K
M
R
S
E
N
A
V
Y
G
G
E
M
S
A
H
H
Y
F
R
E
--
F
-
A
-
Y
-
A
D
S
G
M
I
P
W
L
L
I
A
E
L
V
S
Q
S
G
R
S
L
A
D
L
V
E
A
R
M
Q
K
F
P
---
C
-
S
G
E
I
N
F
K
V
A
-
D
-
A
--
K
A
S
V
A
R
V
M
E
H
Y
A
S
L
-
S
P
-
E
L
D
Y
T
D
G
I
S
A
D
F
G
Q
W
R
F
N
L
R
S
S
N
T
E
P
L
L
R
L
N
V
E
T
R
G
D
---
A
A
L
L
E
T
R
T
Q
E
I
S
N
L
L
R
-------
1
PsiBlast_PDB
99.35
55%
-90
- C1 -
-
5KL0
1
?
A:
[21-466]
-----
T
L
P
A
F
K
A
Y
D
I
R
G
R
V
P
D
E
L
N
E
D
L
A
R
R
I
G
V
A
L
A
A
Q
L
D
-----
Q
G
---
P
V
V
L
G
H
D
V
R
L
A
S
P
A
L
Q
E
A
L
S
A
G
L
R
A
S
G
R
D
V
I
D
I
G
L
C
G
T
E
E
V
Y
F
Q
T
D
Y
--------
L
K
A
A
G
G
V
M
V
T
A
S
H
N
P
M
D
Y
N
G
M
K
L
V
R
E
Q
A
R
P
I
S
S
D
T
G
L
F
A
-
I
R
D
T
V
A
A
D
T
A
A
P
G
--
E
--
P
T
-
A
-
S
E
Q
S
R
-
T
D
K
T
A
Y
L
E
H
L
L
S
Y
V
D
R
S
--
T
--
L
K
P
L
K
L
V
V
N
A
G
N
G
G
A
G
L
I
V
D
L
L
-----
A
P
H
L
P
F
E
F
V
R
V
F
H
E
P
D
G
N
F
P
N
G
I
P
N
P
L
L
P
E
N
R
D
A
T
A
K
A
V
K
D
N
G
A
D
F
G
I
A
W
D
G
D
F
D
R
C
F
F
F
D
H
T
G
R
F
I
E
G
Y
Y
L
V
G
L
L
A
Q
A
I
L
A
K
Q
P
--
G
G
-
K
V
V
H
D
P
R
L
T
W
N
T
V
E
Q
V
E
E
A
G
G
I
P
V
L
C
K
S
G
H
A
F
I
K
E
K
M
R
S
E
N
A
V
Y
G
G
E
M
S
A
H
H
Y
F
R
E
--
F
-
A
-
Y
-
A
D
S
G
M
I
P
W
L
L
I
A
E
L
V
S
Q
S
G
R
S
L
A
D
L
V
E
A
R
M
Q
K
F
P
---
C
-
S
G
E
I
N
F
K
V
A
-
D
-
A
--
K
A
S
V
A
R
V
M
E
H
Y
A
S
L
-
S
P
-
E
L
D
Y
T
D
G
I
S
A
D
F
G
Q
W
R
F
N
L
R
S
S
N
T
E
P
L
L
R
L
N
V
E
T
R
G
D
---
A
A
L
L
E
T
R
T
Q
E
I
S
N
L
L
R
-------
3
PsiBlast_PDB
99.15
55%
-90
- C1 -
-
5BMP
1
?
A:
[22-467]
-----
T
L
P
A
F
K
A
Y
D
I
R
G
R
V
P
D
E
L
N
E
D
L
A
R
R
I
G
V
A
L
A
A
Q
L
D
-----
Q
G
---
P
V
V
L
G
H
D
V
R
L
A
S
P
A
L
Q
E
A
L
S
A
G
L
R
A
S
G
R
D
V
I
D
I
G
L
C
G
T
E
E
V
Y
F
Q
T
D
Y
--------
L
K
A
A
G
G
V
M
V
T
A
S
H
N
P
M
D
Y
N
G
M
K
L
V
R
E
Q
A
R
P
I
S
S
D
T
G
L
F
A
-
I
R
D
T
V
A
A
D
T
A
A
P
G
--
E
--
P
T
-
A
-
S
E
Q
S
R
-
T
D
K
T
A
Y
L
E
H
L
L
S
Y
V
D
R
S
--
T
--
L
K
P
L
K
L
V
V
N
A
G
N
G
G
A
G
L
I
V
D
L
L
-----
A
P
H
L
P
F
E
F
V
R
V
F
H
E
P
D
G
N
F
P
N
G
I
P
N
P
L
L
P
E
N
R
D
A
T
A
K
A
V
K
D
N
G
A
D
F
G
I
A
W
D
G
D
F
D
R
C
F
F
F
D
H
T
G
R
F
I
E
G
Y
Y
L
V
G
L
L
A
Q
A
I
L
A
K
Q
P
--
G
G
-
K
V
V
H
D
P
R
L
T
W
N
T
V
E
Q
V
E
E
A
G
G
I
P
V
L
C
K
S
G
H
A
F
I
K
E
K
M
R
S
E
N
A
V
Y
G
G
E
M
S
A
H
H
Y
F
R
E
--
F
-
A
-
Y
-
A
D
S
G
M
I
P
W
L
L
I
A
E
L
V
S
Q
S
G
R
S
L
A
D
L
V
E
A
R
M
Q
K
F
P
---
C
-
S
G
E
I
N
F
K
V
A
-
D
-
A
--
K
A
S
V
A
R
V
M
E
H
Y
A
S
L
-
S
P
-
E
L
D
Y
T
D
G
I
S
A
D
F
G
Q
W
R
F
N
L
R
S
S
N
T
E
P
L
L
R
L
N
V
E
T
R
G
D
---
A
A
L
L
E
T
R
T
Q
E
I
S
N
L
L
R
-------
35
HHSearch
90.00
53%
-59
- C1 -
-
5BMN
-
?
A:
[21-466]
----
M
T
L
P
A
F
K
A
Y
D
I
R
G
R
V
P
D
E
L
N
E
D
L
A
R
R
I
G
V
A
L
A
A
Q
L
D
-----
Q
G
---
P
V
V
L
G
H
D
V
R
L
A
S
P
A
L
Q
E
A
L
S
A
G
L
R
A
S
G
R
D
V
I
D
I
G
L
C
G
T
E
E
V
Y
F
Q
T
D
Y
--------
L
K
A
A
G
G
V
M
V
T
A
S
H
N
P
M
D
Y
N
G
M
K
L
V
R
E
Q
A
R
P
I
S
S
D
T
G
L
F
A
-
I
R
D
T
V
A
A
D
T
A
A
P
G
--
E
--
P
T
-
A
-
S
E
Q
S
R
-
T
D
K
T
A
Y
L
E
H
L
L
S
Y
V
D
R
S
--
T
--
L
K
P
L
K
L
V
V
N
A
G
N
G
G
A
G
L
I
V
D
L
L
A
P
H
L
---
P
--
F
E
F
V
R
V
F
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G
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F
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I
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L
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A
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A
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G
A
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G
I
A
W
D
G
D
F
D
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C
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F
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G
Y
Y
L
V
G
L
L
A
Q
A
I
L
A
K
Q
P
--
G
G
K
V
V
H
D
P
R
L
T
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N
T
V
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Q
V
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A
-
G
G
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P
V
L
C
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S
G
H
A
F
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K
M
R
S
E
N
A
V
Y
G
G
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M
S
A
H
H
Y
F
R
E
--
F
-
A
-
Y
-
A
D
S
G
M
I
P
W
L
L
I
A
E
L
V
S
Q
S
G
R
S
L
A
D
L
V
E
A
R
M
Q
K
F
P
---
C
-
S
G
E
I
N
F
K
V
A
-
D
A
K
--
A
S
V
A
R
V
M
E
H
Y
A
S
L
--
S
P
-
E
L
D
Y
T
D
G
I
S
A
D
F
G
Q
W
R
F
N
L
R
S
S
N
T
E
P
L
L
R
L
N
V
E
T
R
G
D
A
A
L
L
E
T
R
T
Q
---
E
I
S
N
L
L
--------
34
HHSearch
89.19
53%
-59
- C1 -
-
5BMP
1
?
A:
[21-466]
----
M
T
L
P
A
F
K
A
Y
D
I
R
G
R
V
P
D
E
L
N
E
D
L
A
R
R
I
G
V
A
L
A
A
Q
L
D
-----
Q
G
---
P
V
V
L
G
H
D
V
R
L
A
S
P
A
L
Q
E
A
L
S
A
G
L
R
A
S
G
R
D
V
I
D
I
G
L
C
G
T
E
E
V
Y
F
Q
T
D
Y
--------
L
K
A
A
G
G
V
M
V
T
A
S
H
N
P
M
D
Y
N
G
M
K
L
V
R
E
Q
A
R
P
I
S
S
D
T
G
L
F
A
-
I
R
D
T
V
A
A
D
T
A
A
P
G
--
E
--
P
T
-
A
-
S
E
Q
S
R
-
T
D
K
T
A
Y
L
E
H
L
L
S
Y
V
D
R
S
--
T
--
L
K
P
L
K
L
V
V
N
A
G
N
G
G
A
G
L
I
V
D
L
L
A
P
H
L
---
P
--
F
E
F
V
R
V
F
H
E
P
D
G
N
F
P
N
G
I
P
N
P
L
L
P
E
N
R
D
A
T
A
K
A
V
K
D
N
G
A
D
F
G
I
A
W
D
G
D
F
D
R
C
F
F
F
D
H
T
G
R
F
I
E
G
Y
Y
L
V
G
L
L
A
Q
A
I
L
A
K
Q
P
--
G
G
K
V
V
H
D
P
R
L
T
W
N
T
V
E
Q
V
E
E
A
-
G
G
I
P
V
L
C
K
S
G
H
A
F
I
K
E
K
M
R
S
E
N
A
V
Y
G
G
E
M
S
A
H
H
Y
F
R
E
--
F
-
A
-
Y
-
A
D
S
G
M
I
P
W
L
L
I
A
E
L
V
S
Q
S
G
R
S
L
A
D
L
V
E
A
R
M
Q
K
F
P
---
C
-
S
G
E
I
N
F
K
V
A
-
D
A
K
--
A
S
V
A
R
V
M
E
H
Y
A
S
L
--
S
P
-
E
L
D
Y
T
D
G
I
S
A
D
F
G
Q
W
R
F
N
L
R
S
S
N
T
E
P
L
L
R
L
N
V
E
T
R
G
D
A
A
L
L
E
T
R
T
Q
---
E
I
S
N
L
L
--------
30
HHSearch
68.72
30%
-1
- C1 -
-
1P5D
1
ALGC_PSEAE
X:
[9-452]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
ARG--
E
P
---
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
-
I
Q
A
-
L
R
E
R
I
E
K
N
D
L
A
----
S
--
G
V
-
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
--
A
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
---
G
--
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
--
R
W
F
-
G
-
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
---
T
P
E
I
N
I
T
V
T
E
D
-
S
-
K
--
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
-
E
G
-
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
T
V
F
R
N
Q
L
-----------
12
PsiBlast_PDB
68.12
32%
6
- C1 -
-
2FKM
1
ALGC_PSEAE
X:
[11-444]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
D
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
33
HHSearch
68.03
28%
13
- C1 -
-
1WQA
-
?
D:
[3-450]
-------
K
L
F
G
T
F
G
V
R
G
I
A
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
REGRK
K
P
---
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
--------
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
-
V
E
E
L
F
F
K
E
D
F
D
R
A
KW
Y
--
E
I
-
G
-
E
V
R
R
E
-
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
V
E
--
A
IK
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
---
G
--
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
E
-
E
N
L
K
E
F
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
--
G
G
-
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
--
H
-
V
-
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
Q
---
I
-
K
T
K
R
H
V
E
G
--
D
-
R
--
H
A
I
V
N
K
V
A
E
M
A
R
E
R
-
G
Y
-
T
V
D
T
T
D
G
A
K
I
I
F
E
D
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
-
K
A
Q
E
Y
L
N
L
G
I
E
L
L
-----------
9
PsiBlast_PDB
67.88
32%
7
- C1 -
-
1P5G
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
8
PsiBlast_PDB
67.71
32%
6
- C1 -
-
1P5D
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
21
Fugue
67.68
31%
25
* C1 *
-
1K2Y
1
ALGC_PSEAE
X:
[5-463]
KAP
T
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
G
E
T
L
--
A
N
E
Q
I
Q
A
-
L
R
E
R
I
E
K
N
D
L
A
S
------
G
V
-
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
-----
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
--
R
-
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
F
S
A
F
-
P
S
D
I
---
S
-
T
P
E
I
N
I
T
V
T
-
E
-
D
SK
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
-
E
G
-
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
S
SLPVPF
10
PsiBlast_PDB
67.68
32%
6
- C1 -
-
1PCJ
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
4
PsiBlast_PDB
67.55
32%
5
- C1 -
-
4MRQ
12
ALGC_PSEAE
A:
[4-437]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
S
D
I
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
11
PsiBlast_PDB
67.38
32%
6
- C1 -
-
1PCM
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
7
PsiBlast_PDB
67.19
32%
8
- C1 -
-
2H5A
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
13
PsiBlast_PDB
67.08
32%
4
- C1 -
-
2FKF
1
ALGC_PSEAE
A:
[11-444]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
31
HHSearch
66.82
24%
4
- C1 -
-
2F7L
-
?
A:
[4-451]
--------
L
F
G
T
D
G
V
R
G
I
V
N
K
E
L
T
P
E
L
V
L
K
L
S
K
A
I
G
T
F
F
G
K----
N
S
---
K
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
--------
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
-
E
N
E
-
I
E
D
L
F
F
T
E
R
F
N
T
I
--
E
WS
S
L
-
T
T
E
V
K
R
E
D
R
V
I
S
T
Y
V
N
G
I
L
S
H
V
D
I
E
K
I
K
--
K
K
N
Y
K
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
L
---
G
--
C
K
I
Y
T
I
N
G
N
L
D
P
L
F
S
A
R
Q
P
E
P
T
F
-
D
S
L
K
E
T
A
E
V
V
K
T
L
K
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
S
Y
W
A
S
V
K
N
P
KA
I
K
-
K
I
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
--
H
-
Q
-
Y
-
V
R
D
G
A
M
S
F
A
L
M
L
E
L
L
A
N
E
N
V
S
S
A
E
L
F
D
R
L
P
K
Y
Y
L
---
V
-
K
T
K
V
D
L
K
P
G
L
M
-
V
--
E
E
I
Y
K
K
I
L
E
V
Y
S
T
S
-
S
V
-
K
A
I
T
I
D
G
V
K
I
I
G
K
D
F
W
F
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
-
V
A
N
N
L
V
N
E
L
K
K
I
------------
43
HHSearch
66.70
31%
5
- C1 -
-
3UW2
8
?
A:
[24-474]
-----
S
Q
S
I
F
K
A
Y
D
I
R
G
V
I
G
K
T
L
D
A
D
V
A
R
S
I
G
R
A
F
G
S
E
V
R
A
Q
G--
G
D
---
A
V
V
V
A
R
D
G
R
L
S
G
P
E
L
V
G
A
L
A
D
G
L
R
A
A
G
V
D
V
V
D
V
G
M
V
P
T
P
V
G
Y
F
A
A
S
V
PLALSG
G
E
R
R
V
D
S
C
I
V
V
T
G
S
H
N
P
P
D
Y
N
G
F
K
M
V
L
R
-
G
A
A
I
Y
G
D
Q
-
I
Q
G
-
L
Y
K
R
I
V
D
A
R
F
E
----
T
--
G
S
-
G
-
S
Y
E
Q
Y
-
D
V
A
D
Q
Y
V
E
R
I
V
G
D
I
K
----
L
--
T
R
P
L
K
L
V
V
D
A
G
N
G
V
A
G
P
L
A
T
R
L
F
K
A
L
---
G
--
C
E
L
V
E
L
F
T
D
I
D
G
N
F
P
N
H
H
P
D
P
A
H
P
E
N
L
Q
D
V
I
A
K
L
K
A
T
D
A
E
I
G
F
A
F
D
G
D
G
D
R
L
G
V
V
T
K
D
G
Q
I
I
Y
P
D
R
Q
L
M
L
F
A
E
E
V
L
S
R
N
P
--
G
A
-
Q
I
I
Y
D
V
K
C
T
R
N
L
A
R
W
V
R
E
K
G
G
E
P
L
M
W
K
T
G
H
S
L
V
K
A
K
L
R
E
T
G
A
P
L
A
G
E
M
S
G
H
V
F
F
K
D
--
R
-
W
Y
G
-
F
D
D
G
L
Y
T
G
A
R
L
L
E
I
L
A
R
V
A
-
D
P
S
A
L
L
N
G
L
P
N
A
V
S
---
T
P
E
L
Q
L
--------
N
--
V
K
L
I
D
K
L
R
A
D
A
K
F
D
G
A
D
-
E
V
V
T
I
D
G
L
R
V
E
Y
P
D
G
F
G
L
A
R
S
S
N
T
T
P
V
V
V
L
R
F
E
A
T
S
D
A
-
A
L
A
R
I
Q
D
D
F
R
R
A
L
-----------
5
PsiBlast_PDB
66.37
32%
7
- C1 -
-
1K2Y
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
6
PsiBlast_PDB
66.28
32%
6
- C1 -
-
2H4L
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
----
S
E
H
V
F
S
A
F
P
SDI
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
14
PsiBlast_PDB
64.02
32%
7
- C1 -
-
3BKQ
1
ALGC_PSEAE
X:
[12-445]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-----
A
R
GEP
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
------
V
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--
A
--
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
--
K
----
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
-----
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
--
G
A
-
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
-
F
--
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
G
S
D
I
---
S
-
T
P
E
I
N
I
T
V
T
E
D
-
S
--
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
-
G
E
G
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
-
E
L
E
R
I
K
------------------
32
HHSearch
50.42
30%
3
- C1 -
-
4MRQ
12
ALGC_PSEAE
A:
[2-445]
-----
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G--
E
P
---
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
-
I
Q
A
-
L
R
E
R
I
E
K
N
D
L
A
----
S
--
G
V
-
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
------
A
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
---
G
--
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
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K
D
L
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V
K
A
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A
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L
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D
G
D
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V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
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--
G
A
-
D
I
I
F
D
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K
C
T
R
R
L
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A
L
I
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G
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G
G
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W
K
T
G
H
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L
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K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
--
R
W
F
-
G
-
F
D
D
G
I
Y
S
A
A
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L
L
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I
L
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Q
D
Q
R
D
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H
V
F
S
A
F
P
S
D
I
S
---
T
P
E
I
N
I
T
V
T
E
D
-
S
-
K
--
F
A
I
I
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A
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A
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W
G
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N
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G
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A
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A
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-
E
L
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T
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F
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N
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L
K
----------