@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTZ5: (2017-12-16 )
MSLLNHFATELDELKQQGNFRQFTQNVQHGRFITIQNKTMLNLASNDYLGLAADINLRQEFLDSYPLERSYFSSSSSRLLTGNFDEYEQLENSLSQAFSGRAALLFNSGYHMNIGILPAVADSKTLILADKLVHASMIDGIRLSGAQYVRYRHNDLQHLEQLLQKYHDDDQIERIIVVTESIFSMDGDETDLTALVQLKKRFAKTMLYVDEAHSIGVRGQQGLGCAEQYNVIQEIDFLVGTLGKALAAVGGYIICDQIIKDYLINKMRPLIFSTAQPPIVMAWANFIFKKVLMAQSQREHLKNISQYLQQAVVQKGYVSPSTSHIIPVIVGESQATIDKAKQVQESGFYAMPVRPPTVPKNSSRLRISLTSMVEQHELEALVSFL
Atome Classification :
(24 SA)
.........10.......-.20-..--.--.....30..-------......40........50...---.....60........70........80........90........100--.-----........110.......120-........130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240......-.250.......260.......270.......280.......290-..-----.--..-----...300..---.....310.....---.-.-320....--.....330.......340..-.....350.......360.......370.......380...----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
L
N
H
F
A
T
E
L
D
E
L
K
QQG-
N
F
R
-
Q
F
--
T
--
Q
NVQHG
R
F
I
-------
T
IQN
K
T
M
L
NLASND
Y
L
G
L
A
A
D
---
I
N
L
R
Q
E
F
L
D
SYPL
E
R
SYFSSSS
S
R
L
L
TGN
F
D
E
Y
E
Q
L
E
N
S
L
S
Q
A
FSG----
R
-----
A
A
L
L
FNSG
Y
H
M
N
I
G
I
L
PAVA--DS
K
T
L
I
L
A
D
K
L
V
H
A
S
MID
G
I
R
LSG
A
Q
Y
V
R
Y
RHN
D
L
Q
H
L
E
Q
L
L
Q
K
YH
D
D
D
Q
I
E
R
I
I
V
V
T
E
S
I
FSMDGD
E
T
D
L
T
A
L
V
Q
L
K
K
R
F
A
K
T
M
L
Y
VDEAHSIGVRGQQGLG
C
A
E
Q
Y
N
V
I
Q
E
I
D
F
L
V
G
T
L
G
K
A
L
A
A
-VG
G
Y
I
I
C
D
Q
I
I
K
D
Y
L
I
N
KM
R
P
L
IFSTAQP
P
I
V
M
A
W
A
N
F
I
F
K
K
V
--
L
M
-----
A
--
Q
S
-----
Q
R
E
H
L
K
N
I
---
S
Q
Y
L
Q
Q
A
V
V
QKGY---V-S-P--STS
H
--
I
I
P
V
I
VGESQA
T
I
D
K
A
K
Q
V
Q
-ESG
F
Y
AMPVRPPTVPKNS
S
R
L
R
I
S
L
T
S
M
V
E
Q
H
E
L
E
A
L
V
SFL----
44
HHSearch
83.16
33%
-6
- C1 -
-
5VNX
7
BIOF_BURM1
A:
[2-386]
-
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
-
L
R
R
-
V
R
--
R
T
A
D
S
A
C
-
D
A
H
M
-------
T
V
N
G
R
E
I
V
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
K
L
V
A
A
F
A
E
--
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
G
FSD
A
P
-----
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
L
A
--
G
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
----
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
-
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
-
A
A
G
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
G
-----
D
E
G
D
A
-----
R
R
A
H
L
A
A
L
---
I
E
R
T
R
A
L
L
R
R
T
R
W
---
Q
-
P
V
D
--
S
H
T
A
--
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
A
R
L
E
T
A
L
----
45
HHSearch
82.88
33%
-6
* C1 *
-
5VNX
4
BIOF_BURM1
C:
[2-386]
-
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
-
L
R
R
-
V
R
--
R
T
A
D
S
A
C
-
D
A
H
M
-------
T
V
N
G
R
E
I
V
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
K
L
V
A
A
F
A
E
--
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
G
FSD
A
P
-----
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
L
A
--
G
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
----
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
-
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
-
A
A
G
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
G
-----
D
E
G
D
A
-----
R
R
A
H
L
A
A
L
---
I
E
R
T
R
A
L
L
R
R
T
R
W
---
Q
-
P
V
D
--
S
H
T
A
--
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
A
R
L
E
T
A
L
----
50
HHSearch
82.56
30%
-102
- C1 -
-
2X8U
-
?
A:
[42-389]
-----------------------------------------------
I
N
G
R
K
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
---
P
D
V
I
A
A
G
K
Q
--
A
L
D
E
F
G
S
G
T
T
G
S
R
V
L
N
G
T
Y
Q
G
H
K
A
C
E
D
A
L
K
E
F
Y
G
T
----
E
-----
H
A
I
V
F
S
T
G
Y
Q
A
N
L
G
M
I
S
T
L
A
--
G
K
G
D
Y
I
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
W
L
G
D
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
---
A
E
A
G
K
L
V
V
L
E
G
V
Y
S
M
M
G
D
I
A
P
L
Q
E
M
V
A
V
S
K
K
H
G
-
A
M
I
L
V
D
E
A
H
G
M
G
F
F
G
E
H
G
R
G
V
F
E
E
A
G
V
E
A
D
V
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
G
G
F
C
V
S
N
H
P
K
F
E
V
L
R
L
V
C
R
P
Y
V
F
T
A
S
L
P
P
S
V
V
A
T
A
A
T
S
I
R
K
L
--
M
H
-----
A
--
G
D
-----
K
R
A
H
L
W
K
N
---
S
R
R
L
H
Q
G
L
R
D
M
G
Y
---
K
-
L
G
T
ET
A
Q
S
A
--
I
I
A
V
I
L
T
D
M
A
Q
A
V
A
L
W
Q
G
L
L
-
E
A
G
L
Y
V
N
T
A
R
P
P
A
T
P
A
G
M
F
L
L
R
C
S
L
C
A
E
H
S
D
E
Q
V
E
Q
I
L
G
M
F
----
23
PsiBlast_CBE
80.23
33%
-17
- C1 -
-
5VNX
7
BIOF_BURM1
A:
[1-372]
M
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
-
L
R
R
V
R
R
--
T
--
A
D
S
A
C
D
A
H
M
-------
T
V
N
G
R
E
I
V
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
K
L
V
A
A
F
A
E
G
A
--
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
-
G
F
A
G
----
G
FSD
A
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
L
A
--
G
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
S
Q
T
K
----
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
-
W
L
V
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
G
V
A
--
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
G
D
E
---
G
--
D
A
-----
R
R
A
H
L
A
A
L
---
I
E
R
T
R
A
L
L
R
R
T
R
W
-----
Q
-
P
--
V
D
S
H
TA
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
------------------
36
HHSearch
79.98
27%
-122
- C1 -
-
3KKI
4
CQSA_VIBCH
A:
[58-397]
-------------------------------------------------
S
P
D
D
I
I
L
Q
S
N
D
Y
L
A
L
A
N
H
---
P
L
I
K
A
R
L
A
K
--
S
L
L
E
E
Q
Q
S
L
F
M
S
A
S
F
L
Q
N
D
Y
D
K
P
M
I
E
K
R
L
A
K
F
T
G
F
----
D
-----
E
C
L
L
S
Q
S
G
W
N
A
N
V
G
L
L
Q
T
I
C
--
Q
P
N
T
N
V
Y
I
D
F
F
A
H
M
S
L
W
E
G
A
R
Y
A
N
A
Q
A
H
P
F
M
H
N
N
C
D
H
L
R
M
L
I
Q
R
------
H
G
P
G
I
I
V
V
D
S
I
Y
S
T
L
G
T
I
A
P
L
A
E
L
V
N
I
S
K
E
F
G
-
C
A
L
L
V
D
E
S
H
S
L
G
T
H
G
P
N
G
A
G
L
L
A
E
L
G
L
T
R
E
V
H
F
M
T
A
S
L
A
K
T
F
A
Y
-
R
A
G
A
I
W
C
N
N
E
V
N
R
C
V
P
F
I
S
Y
P
A
I
F
S
S
T
L
L
P
Y
E
A
A
G
L
E
T
T
L
E
I
I
--
E
S
-----
A
--
D
N
-----
R
R
Q
H
L
D
R
M
---
A
R
K
L
R
I
G
L
S
Q
L
G
L
---
T
-
I
-
R
--
S
E
S
Q
--
I
I
G
L
E
T
G
D
E
R
N
T
E
K
V
R
D
Y
L
E
-
S
N
G
V
F
G
S
V
F
C
R
P
A
T
S
K
N
K
N
I
I
R
L
S
L
N
S
D
V
N
D
E
Q
I
A
K
I
I
E
V
C
----
21
PsiBlast_CBE
79.73
33%
-17
- C1 -
-
5VNX
4
BIOF_BURM1
C:
[2-372]
-
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
-
L
R
R
V
R
R
--
T
--
A
D
S
A
C
D
A
H
M
-------
T
V
N
G
R
E
I
V
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
K
L
V
A
A
F
A
E
G
A
--
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
-
G
F
A
G
----
G
FSD
A
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
L
A
--
G
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
S
Q
T
K
----
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
-
W
L
V
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
G
V
A
--
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
G
D
E
---
G
--
D
A
-----
R
R
A
H
L
A
A
L
---
I
E
R
T
R
A
L
L
R
R
T
R
W
-----
Q
-
P
--
V
D
S
H
TA
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
------------------
48
HHSearch
79.32
27%
-124
- C1 -
-
2WKA
2
CQSA_VIBCH
A:
[37-377]
------------------------------------------------
A
S
P
D
D
I
I
L
Q
S
N
D
Y
L
A
L
A
N
H
---
P
L
I
K
A
R
L
A
K
--
S
L
L
E
E
Q
Q
S
L
F
M
S
A
S
F
L
Q
N
D
Y
D
K
P
M
I
E
K
R
L
A
K
F
T
G
F
----
D
-----
E
C
L
L
S
Q
S
G
W
N
A
N
V
G
L
L
Q
T
I
C
--
Q
P
N
T
N
V
Y
I
D
F
F
A
H
M
S
L
W
E
G
A
R
Y
A
N
A
Q
A
H
P
F
M
H
N
N
C
D
H
L
R
M
L
I
Q
R
------
H
G
P
G
I
I
V
V
D
S
I
Y
S
T
L
G
T
I
A
P
L
A
E
L
V
N
I
S
K
E
F
G
-
C
A
L
L
V
D
E
S
H
S
L
G
T
H
G
P
N
G
A
G
L
L
A
E
L
G
L
T
R
E
V
H
F
M
T
A
S
L
A
K
T
F
A
Y
-
R
A
G
A
I
W
C
N
N
E
V
N
R
C
V
P
F
I
S
Y
P
A
I
F
S
S
T
L
L
P
Y
E
A
A
G
L
E
T
T
L
E
I
I
--
E
S
-----
A
--
D
N
-----
R
R
Q
H
L
D
R
M
---
A
R
K
L
R
I
G
L
S
Q
L
G
L
---
T
-
I
-
R
--
S
E
S
Q
--
I
I
G
L
E
T
G
D
E
R
N
T
E
K
V
R
D
Y
L
E
-
S
N
G
V
F
G
S
V
F
C
R
P
A
T
S
K
N
K
N
I
I
R
L
S
L
N
S
D
V
N
D
E
Q
I
A
K
I
I
E
V
C
----
24
Fugue
78.88
30%
-33
- C1 -
-
1BS0
-
BIOF_ECOLI
A:
[2-384]
-
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
-
A
L
R
-
R
R
Y
-
P
--
V
A
Q
G
A
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
---
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
--
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
----
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
-
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
R
S
D
E
-----
G
--
D
A
-----
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
---
T
L
A
-
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
22
PsiBlast_CBE
78.66
33%
-15
- C1 -
-
5VNX
5
BIOF_BURM1
B:
[2-372]
-
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
-
L
R
R
V
R
R
--
T
--
A
D
S
A
C
D
A
H
M
-------
T
V
N
G
R
E
I
V
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
K
L
V
A
A
F
A
E
G
A
--
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
-
G
F
A
G
----
G
FSD
A
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
L
A
--
G
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
S
Q
T
K
----
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
-
L
L
A
L
A
E
R
H
G
A
-
W
L
V
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
G
V
A
--
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
G
D
E
---
G
--
D
A
-----
R
R
A
H
L
A
A
L
---
I
E
R
T
R
A
L
L
R
R
T
R
W
-----
Q
-
P
--
V
D
S
H
TA
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
------------------
3
PsiBlast_PDB
78.41
32%
-11
- C1 -
-
5JAY
-
BIOF_PARXL
A:
[11-394]
--
L
L
D
T
L
A
E
G
L
K
E
I
D
A
R
G
L
R
R
R
-
R
R
--
T
--
A
D
T
P
C
A
A
H
M
-------
T
V
D
G
R
A
I
I
G
F
A
S
N
D
Y
L
G
L
A
A
H
---
P
Q
L
I
A
A
I
A
E
G
A
--
Q
R
Y
G
A
G
S
G
-------
H
S
R
A
H
A
Q
L
E
D
D
L
A
E
F
V
G
G
FVEN
A
-----
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
T
L
T
A
L
A
--
G
R
G
T
T
L
F
S
D
A
L
N
H
A
S
L
I
D
G
A
R
L
S
R
A
D
V
Q
I
Y
P
H
C
D
T
D
A
L
S
A
M
L
E
A
S
D
A
D
V
K
V
----
I
V
S
D
T
V
F
S
M
D
G
D
I
A
P
L
P
R
L
L
E
L
A
E
Q
H
G
-
A
W
L
I
V
D
D
A
H
G
F
G
V
L
G
P
Q
G
R
G
A
I
A
Q
A
A
L
R
S
P
N
L
I
S
I
G
T
L
D
K
A
A
G
V
-
S
G
A
F
V
A
A
H
E
T
V
I
E
W
L
V
Q
R
A
R
P
Y
I
F
T
T
A
S
V
P
---
A
A
A
H
A
V
S
A
S
L
--
R
I
I
G
G
E
E
G
--
D
A
-----
R
R
A
H
L
Q
Q
L
---
I
G
R
-
T
R
A
M
L
K
A
T
P
---
W
-
L
-
P
--
V
D
S
H
TA
V
Q
P
L
I
I
G
A
N
D
A
T
L
E
I
A
A
T
L
D
-
R
A
G
L
W
V
P
A
I
R
P
P
T
V
P
T
G
T
S
R
L
R
I
S
L
S
A
A
H
S
Q
A
D
L
D
R
L
E
A
G
L
----
41
HHSearch
77.39
31%
-8
- C1 -
-
1DJE
1
BIOF_ECOLI
A:
[2-380]
-
S
W
Q
E
K
I
N
A
A
L
D
A
R
G
A
A
D
-
A
L
R
-
R
R
--
Y
P
V
A
Q
G
A
-
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
---
P
Q
I
I
R
A
W
Q
Q
--
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
----
P
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
-
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
-----
D
E
G
D
A
-----
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
---
T
-
L
A
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
----
42
HHSearch
76.80
31%
-10
- C1 -
-
1BS0
-
BIOF_ECOLI
A:
[2-380]
-
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
-
A
L
R
-
R
R
--
Y
P
V
A
Q
G
A
-
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
---
P
Q
I
I
R
A
W
Q
Q
--
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
----
P
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
-
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
-----
D
E
G
D
A
-----
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
---
T
-
L
A
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
----
11
PsiBlast_PDB
75.62
28%
-99
- C1 -
-
2W8J
1
?
A:
[61-394]
-----------------------------------------------
I
R
G
K
D
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
---
P
D
V
I
A
A
G
K
E
A
--
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
----
T
-----
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
E
P
A
---
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
-
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
-----
A
--
H
E
-----
K
R
E
R
L
W
S
N
---
A
R
A
L
H
G
G
L
K
A
M
G
F
RLG
T
-
E
-
T
--
C
D
S
A
--
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
------------------
46
HHSearch
75.07
27%
-18
- C1 -
-
1FC4
2
KBL_ECOLI
B:
[9-390]
---
Y
Q
Q
L
T
N
D
L
E
T
A
R
A
E
G
-
L
F
K
-
E
E
--
R
II
T
S
A
Q
-
Q
A
D
I
T------
V
A
D
G
S
H
V
I
N
F
C
A
N
N
Y
L
G
L
A
N
H
---
P
D
L
I
A
A
A
K
A
--
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
----
E
-----
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
E
-
A
G
A
R
H
V
L
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
-
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
I
T
G
T
L
G
K
A
L
G
G
A
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
A
-----
G
--
S
E
-----
L
R
D
R
L
W
A
N
---
A
R
Q
F
R
E
Q
M
S
A
A
G
F
---
T
-
L
A
G
--
A
D
H
A
--
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
-
K
E
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
----
19
PsiBlast_PDB
75.04
28%
-99
- C1 -
-
4BMK
6
?
A:
[83-416]
-----------------------------------------------
I
R
G
K
D
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
---
P
D
V
I
A
A
G
K
E
A
--
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
----
T
-----
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
E
P
A
---
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
-
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
A
S
V
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
-----
A
--
H
E
-----
K
R
E
R
L
W
S
N
---
A
R
A
L
H
G
G
L
K
A
M
G
F
R
L
G
T
-
E
-
T
--
C
D
S
A
--
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
------------------
12
PsiBlast_PDB
74.35
28%
-98
- C1 -
-
2XBN
1
?
A:
[61-394]
-----------------------------------------------
I
R
G
K
D
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
---
P
D
V
I
A
A
G
K
E
A
--
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
----
T
-----
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
E
P
A
---
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
-
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
-----
A
--
H
E
-----
K
R
E
R
L
W
S
N
---
A
R
A
L
H
G
G
L
K
A
M
G
F
RLG
T
-
E
-
T
--
C
D
S
A
--
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
------------------
35
HHSearch
74.15
28%
0
- C1 -
-
2BWN
3
HEM1_RHOCB
E:
[2-393]
-
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
-
R
Y
R
-
T
F
--
I
DI
E
R
E
K
-
G
A
F
P
KAQWNRP
D
G
G
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
---
P
V
V
L
A
A
M
H
E
--
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
----
E
-----
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
VL
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
---
P
A
A
P
K
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
-
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
G
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
-----
A
EG
Q
K
-----
L
R
D
A
Q
Q
M
H
---
A
K
V
L
K
M
R
L
K
A
L
G
M
---
P
-
I
I
D
--
H
G
S
H
--
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
----
49
HHSearch
73.91
30%
4
- C1 -
-
3A2B
2
?
A:
[13-385]
--------
K
I
V
E
E
L
K
A
K
G
-
L
Y
A
-
Y
F
--
R
PI
Q
S
K
Q
-
D
T
E
V
-------
K
I
D
G
R
R
V
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
---
T
R
I
I
K
A
A
Q
D
--
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
----
E
-----
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
---
E
D
S
A
K
L
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
-
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
A
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
-----
E
--
P
E
-----
H
I
E
K
L
W
K
N
---
T
D
Y
A
K
A
Q
L
L
D
H
G
F
---
D
-
L
G
A
--
T
E
S
P
--
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
----
17
PsiBlast_PDB
73.84
28%
-99
- C1 -
-
2W8W
1
?
A:
[61-394]
-----------------------------------------------
I
R
G
K
D
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
---
P
D
V
I
A
A
G
K
E
A
--
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
----
T
-----
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
E
P
A
---
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
-
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
-----
A
--
H
E
-----
K
R
E
R
L
W
S
N
---
A
R
A
L
H
G
G
L
K
A
M
G
F
RLG
T
-
E
-
T
--
C
D
S
A
--
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
------------------
34
HHSearch
73.33
28%
0
- C1 -
-
2BWO
5
HEM1_RHOCB
E:
[1-393]
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
-
R
Y
R
-
T
F
--
I
DI
E
R
E
K
-
G
A
F
P
KAQWNRP
D
G
G
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
---
P
V
V
L
A
A
M
H
E
--
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
----
E
-----
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
VL
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
---
P
A
A
P
K
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
-
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
G
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
-----
A
EG
Q
K
-----
L
R
D
A
Q
Q
M
H
---
A
K
V
L
K
M
R
L
K
A
L
G
M
---
P
-
I
I
D
--
H
G
S
H
--
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
----
6
PsiBlast_PDB
71.25
31%
-24
- C1 -
-
1DJ9
1
BIOF_ECOLI
A:
[31-380]
-----------------------------------
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
-----
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
-
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
--
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
---
A
Q
A
Q
A
L
R
A
S
L
--
A
V
-----
I
--
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
T--
L
-
A
-
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
----
7
PsiBlast_PDB
71.03
31%
-21
- C1 -
-
1DJE
1
BIOF_ECOLI
A:
[31-380]
-----------------------------------
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
-----
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
-
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
--
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
---
A
Q
A
Q
A
L
R
A
S
L
--
A
V
-----
I
--
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
T
--
L
-
A
-
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
----
5
PsiBlast_PDB
70.54
31%
-18
- C1 -
-
2G6W
1
BIOF_ECOLI
A:
[31-380]
-----------------------------------
G
R
W
L
-------
V
A
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
-----
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
----
S
-----
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
-
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
--
L
V
V
T
F
G
K
G
F
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
---
A
Q
A
Q
A
L
R
A
S
L
--
A
V
-----
I
--
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
---
I
T
R
F
R
A
G
V
Q
D
L
P
F
T
--
L
-
A
-
D
--
S
C
S
A
--
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
----
1
PsiBlast_PDB
66.59
30%
6
- C1 -
-
3A2B
2
?
A:
[15-369]
----------
V
E
E
L
K
A
K
G
-
L
Y
A
-
Y
F
RP
I
--
Q
S
K
Q
D
T
E
-
V
-------
K
I
D
G
R
R
V
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
---
T
R
I
I
K
A
A
Q
D
A
--
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
----
E
-----
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
E
D
S
A
---
K
L
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
-
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
A
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
---
L
K
A
L
--
E
I
-----
I
--
Q
N
-----
E
P
E
H
I
E
K
L
W
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
F
D--
L
-
G
-
A
--
T
E
S
P
--
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
--------------------