@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUU0: (2017-12-20 )
MQVYLVGGAVRDYLLGHSYQEKDYVVVGATPEHMLAQGFQPVGKDFPVFLHPETKEEYALARTERKSGQGYHGFQFFTDTTVSLEDDLIRRDLTINAIAMDQDGKIYDPYGGQNDLENKILRHVSEAFAEDPLRVLRVARFAARYFPYGFQIAPETLQLMQTMADSGELDALTPERVWKETSRALMENHADIYFQTLRDCGALKHLFPEIDALFGVPQRPEYHPEVDCGIHTLMSLQQACKSNYSLDVRFAVLVHDLGKALTPAKELPRHIMHEERGIKPVTQLCERLRVPTQTKQLALSVCKEHLKCHQIMSLKPGTLWRLLQRLDVLRRPERVEAFVQACECDAKGRLGLEDRPYPQAQYMREAMQIVRSIKVQDLPENIKGAEIGEMLIQYRIEALAEFKNQHQSLSHS
Atome Classification :
(32 SA)
--------------------------------.........10.......---.20........30...----..--...40------.------..--------...---..50-.---.------------.......-60-.........70........---80-----.------.-.-......90........100.-.---------......110.......120---..-.-.---.---..130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240----.-------------------------.......250...--------....260...---....270......-.280......--.290.-......300---......--.310-..------......320.......330.......340.......350.---.---....-.360.------...---..-.370.-...-...-380-.......390.......400.......410--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------
M
Q
V
Y
L
VG
G
A
V
R
D
Y
L
LGHS---YQEK
D
Y
V
V
VGA
T
P
E
H
M
----
L
A
--QGFQP------V------GK--------DF
P
---
V
F
L--H---P------------E
T
K
E
E
Y
A
-
L
--ARTERKSGQGYH
G
F
Q
F
F
TD---T------T------V-S-
L
E
D
D
L
I
RRD
L
T
I
N
A
I
A
MD-Q-D---------GKIYDPYGGQ
N
D
L
E
N
K
I
L
R
---
H
V
-
S
-
E
---
A
---
F
A
E
D
P
L
R
V
L
R
V
A
R
F
A
A
R
YFPYG
F
Q
I
A
P
E
T
L
Q
L
M
Q
T
M
ADSGELDAL
T
P
E
R
V
W
K
E
T
S
R
A
L
M
E
N
H
A
D
I
Y
F
Q
T
L
R
D
C
G
A
L
K
H
L
F
P
E
I
D
A
L
FGVPQRPEYHPEV
D
C
G
I
H
T
L
M
S
L
Q
Q
A
C
K-----S-------------------------NY
S
L
D
V
R
F
A
V
L
V
H
--------
D
L
G
K
ALT
P
A
K
---
E
L
P
R
H
I
M
H
E
ERGI-
K
P
V
T
Q
L
C
E
R
L--RVP
T
Q
-
T
K
Q
L
A
L
S
V
C
---
K
E
H
L
K
C
--
H
Q
I
--MS------LK
P
G
T
L
W
R
L
L
Q
R
L
D
V
LRR
P
E
R
V
E
A
F
V
Q
A
CECDAKGRLGLE---D---RPY
P
-
Q
A
Q
Y
M
------
R
E
A
---
M
Q
-
I
V
R
S
I
-
K
V
Q
-DLP-ENI-K
G
A
E
I
G
E
M
L
I
Q
Y
R
I
E
A
L
A
E
F
K
N
Q
H
Q
SLSHS--
34
HHSearch
77.73
24%
-16
* C3 *
-
3WFO
-
?
A:
[35-448]
--------------------------------
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
VGY
N
I
D
V
D
F
L
T
T
-
A
D
P
V
E
L
----
A
K
--
N
F
A
K
R
------
I
------
G
G
--------
H
F
F
---
V
F
E
----------------------
P
T
I
A
-
S
--
V
V
L
H
L
---
P
P
-
Y
R
Y
R
F
D
F
S
---
P
------
L
K
G
KD
L
E
K
-
A
-
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
N
-
L
-
D
D
V
L
SIGA
K
Q
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
---
P
V
-
S
-
I
E
--
N
---
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
---
N
L
Q
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
I
P
E
I
G
R
L
R
E
V
K
D
--------
P
L
D
E
H
T
L
K
T
L
E
Y
L
E
Q
-----
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
D
V
E
L
L
K
W
G
A
L
F
H
--------
D
I
G
K
P
Q
T
F
-------
V
T
F
Y
E
H
D
K
V
G
A
-
Q
I
V
R
E
I
G
E
R
L
--
R
W
G
D
E
-
A
T
E
F
V
A
K
L
V
---
R
H
H
L
R
P
--
F
F
L
--
R
E
A
F
K
K
GE
L
K
R
R
G
M
A
N
F
W
R
E
C
G
D
-----
I
A
P
H
L
F
L
L
S
I
A
D
A
M
A
S
G
D
E
E
---
E
D
I
K
A
L
M
E
T
I
A
E
L
E
S
F
N
R
NE
M
K
---------------------------------------------------------
36
HHSearch
76.62
27%
4
- C3 -
-
3WFP
-
?
C:
[21-411]
---------------------------------
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
VGY
N
I
D
V
D
F
L
T
T
-
A
D
P
V
E
L
----
A
K
--
N
F
A
K
R
------
I
------
G
G
--------
H
F
F
---
V
F
E
--
K
---
R
------------
G
F
L
I
K
R
P
T
I
--
A
S
V
V
L
-
H
L
P
P
Y
-
R
Y
R
F
D
F
S
---
P
LKGKDL
E
------
K
-
A
-
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
N
-
L
-
D
DVLSIGAKQ
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
---
P
V
-
S
-
I
E--
N
---
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
---
N
L
Q
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
I
P
E
I
G
R
L
R
E
V
K
D
--------
P
L
D
E
H
T
L
K
T
L
E
Y
L
E
Q
-----
V
IEDRAKYLSAELLENFGKKRVLGEF
T
D
V
E
L
L
K
W
G
A
L
F
H
--------
D
I
G
K
P
Q
T
F
-------
V
T
F
Y
E
H
D
K
V
G
A
-
Q
I
V
R
E
I
G
E
R
L
--
R
W
G
D
E
-
A
T
E
F
V
A
K
L
V
---
R
H
H
L
R
P
--
F
F
L
--
R
E
AFKKGE
L
K
R
R
G
M
A
N
F
W
R
E
C
G
D
-----
I
A
P
H
L
F
L
L
S
I
A
D
A
M
A
S
G
D
E
E
----------------------------------------------------------------------------------
1
PsiBlast_PDB
76.09
29%
-
- C3 -
-
3H38
-
?
A:
[35-350]
--------------------------------
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
---
N
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
---
Y
A
--
K
R
F
L
P
-------------
G
K
L
V
K
H
DKF
M
T
A
S
---
L
F
L
--
K
---
G
------------
G
L
R
I
D
I
A
-
T
--
A
R
L
E
Y
-----
Y
E
S
P
A
K
L
P
D
---
V
------
E
------
M
-
S
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
K
-
L
-
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
---
V
L
H
T
-
L
---
S
---
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
---
D
F
R
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
F
P
----------
K
T
Y
Y
T
P
S
M
D
E
K
M
E
N
L
F
R
N
I
P
W
V
E
-----
E
-------------------------
N
F
G
E
V
D
R
F
Y
A
V
L
H
V
F
L
EFYD
D
E
S
W
K
E
V
R
D
R
Y
---
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
A
L
L
E
M
L
S
E
R
V
P
A
S
F
V
Y
P
L
V
K
G
V
S
---
N
E
T
I
-
C
--
H
--------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
75.27
27%
1
- C3 -
-
3WFP
-
?
A:
[21-360]
---------------------------------
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
VGY
N
I
D
V
D
F
L
T
T
-
A
D
P
V
E
L
----
A
K
--
N
F
A
K
R
------
I
------
G
G
--------
H
F
F
---
V
F
E
--
K
---
R
------------
G
F
L
I
K
R
P
T
I
--
A
S
V
V
L
-
H
L
P
P
Y
-
R
Y
R
F
D
F
S
---
P
L
K
G
KD
L
E
------
K
-
A
-
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
N
-
L
-
D
D
V
L
SIGAKQ
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
---
P
V
-
S
-
I
E
--
N
---
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
---
N
L
Q
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
I
P
E
I
G
R
L
R
E
V
K
D
--------
P
L
D
E
H
T
L
K
T
L
E
Y
L
E
Q
-----
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
D
V
E
L
L
K
W
G
A
L
F
H
--------
D
I
G
K
P
Q
T
F
-------
V
T
F
Y
E
H
D
K
V
G
A
-
Q
I
V
R
E
I
G
E
R
L
--
R
W
G
D
E
-
A
T
E
F
V
A
K
L
V
---
R
H
H
L
R
P
--
F
F
L
--
R
E
A
F
K
K
GE
L
K
R
R
G
M
A
N
F
W
R
E
C
G
D
-----
I
A
P
H
L
F
L
L
S
I
A
D
A
M
A
S
G
D
E
E
----------------------------------------------------------------------------------
3
PsiBlast_PDB
72.90
29%
4
- C3 -
-
5HC9
-
?
A:
[35-350]
--------------------------------
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
---
N
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
---
Y
A
--
K
R
F
L
P
-------------
G
K
L
V
K
H
DKFM
T
A
S
---
L
F
L
--
K
---
G
------------
G
L
R
I
D
I
A
-
T
--
A
R
L
E
Y
-----
Y
E
S
P
A
K
L
P
D
---
V
------
E
------
M
-
S
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
K
-
L
-
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
---
V
L
H
T
-
L
---
S
---
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
---
D
F
R
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
F
P
----------
K
T
Y
Y
T
P
S
M
D
E
K
M
E
N
L
F
R
N
I
P
W
V
E
-----
E
-------------------------
N
F
G
E
V
D
R
F
Y
A
V
L
H
V
F
L
EFYD
D
E
S
W
K
E
V
R
D
R
Y
---
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
A
L
L
E
M
L
S
E
R
V
P
A
S
F
V
Y
P
L
V
K
G
V
S
---
N
E
T
I
-
C
--
H
--------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
72.83
22%
-2
- C3 -
-
5HC9
-
?
A:
[36-416]
---------------------------------
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
---
N
L
D
I
D
I
V
V
E
-
G
N
A
L
E
F
----
A
E
--
Y
A
K
R
F
L
P
G
K
L
V
K
------
H
D
--------
K
F
M
---
T
A
S
--
L
F
L
K
G
------------
G
L
R
I
D
I
A
-
T
--
A
R
L
E
Y
Y
E
S
P
A
K
L
-
P
D
V
------
E
------
M
------
S
-
T
-
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
K
-
L
-
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
---
V
L
-
H
-
T
L--
S
---
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
---
D
F
R
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
F
P
K
T
Y
Y
T
P
S
M
D
E
K
---------
M
E
N
L
F
R
N
I
P
W
V
E
------
E
-------------------------
N
F
G
E
V
D
R
F
Y
A
V
L
H
--------
V
F
L
E
F
Y
------------------
D
D
-
E
S
W
K
E
V
R
D
R
Y
--
S
L
R
R
N
-
L
I
N
E
I
R
H
V
E
---
K
S
A
P
A
L
--
L
E
M
L
S
E
R
------
V
P
A
S
F
V
Y
P
L
V
K
G
V
S
N
----
E
T
I
C
H
F
L
A
Y
----
L
S
G
E
K
E
-----------
G
L
-
F
K
S
Y
L
------
L
K
I
---
K
N
T
K
L
E
K
I
-
N
G
E
Y
L
I
R
-
K
G
I
T
S
G
K
I
I
G
E
V
L
E
K
I
L
M
K
K
L
D
G
D
T
R
D
E
E
E
I
-----
42
HHSearch
70.57
24%
-0
- C3 -
-
1MIW
1
CCA_GEOSE
A:
[21-388]
---------------------------------
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
-
A
L
P
E
D
V
----
M
A
--
I
F
P
K
T
ID----
V
------
G
S
--------
K
H
G
---
T
V
V
--
V
VH-
K
------------
G
K
A
Y
E
V
T
-
T
--
F
K
T
D
G
-----------
S
V
T
---
F
------
V
------
R
-
S
-
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
---
T
V
-
G
-
E
A
E
K
R
---
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
-
L
P
G
L
A
G
K
E
K
--
Q
---
L
R
---------
L
A
A
A
Y
R
W
P
------
W
-------------------------
L
A
A
R
E
E
R
W
A
L
L
C
H
--------
A
L
G
V
Q
E
-----------------------
S
R
P
F
L
R
A
W
--
K
L
P
N
K
-
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
P
R
P
--
E
A
W
-----------
T
N
E
---
Q
L
F
S
-
A
G
L
----
E
R
-----
A
L
S
V
E
T
V
R
A
A
F
T
G
A
PP-
G
---
P
W
H
E
K
L
R
R
R
F
------
A
S
L
PIK
T
K
-
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
-----
48
HHSearch
68.36
24%
-3
- C3 -
-
3AQL
1
?
A:
[34-388]
---------------------------------
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
-
N
A
T
P
E
Q
V
----
R
K
--
L
F
R
N
C
R
L
----
V
------
G
R
--------
R
F
R
---
L
A
H
--
V
M
F
-
G
------------
P
E
I
I
E
V
A
-
T
--
F
R
G
---------------
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
-
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
---
L
I
-
G
-
N
P
E
T
R
---
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
T
E
N
G
D
S
P
M
E
------
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
M
-------------------------
R
V
N
P
A
F
L
F
A
A
M
F
W
Y
-------
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
D
A
F
A
L
A
M
N
-
D
V
L
D
E
A
C
R
S
L
--
A
I
P
K
R
-
L
T
T
L
T
R
D
I
W
---
Q
L
Q
L
R
M
--
S
R
R
--
Q
---------
G
K
R
A
W
K
L
L
E
H
P
K
F
---
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
--------------------------------------------------------------------------------------
41
HHSearch
68.23
24%
3
- C3 -
-
1MIV
-
CCA_GEOSE
B:
[21-388]
---------------------------------
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
-
A
L
P
E
D
V
----
M
A
--
I
F
P
K
T
ID----
V
------
G
S
--------
K
H
G
---
T
V
V
--
V
VH-
K
------------
G
K
A
Y
E
V
T
-
T
--
F
K
T
D
G
-----------
S
V
T
---
F
------
V
------
R
-
S
-
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
---
T
V
-
G
-
E
AEK
R
---
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
-
L
P
G
L
A
G
K
E
K
--
Q
---
L
R
---------
L
A
A
A
Y
R
W
P
------
W
-------------------------
L
A
A
R
E
E
R
W
A
L
L
C
H
--------
A
L
G
V
Q
E
-----------------------
S
R
P
F
L
R
A
W
--
K
L
P
N
K
-
V
V
D
E
A
G
A
I
L
TAL
A
D
I
P
R
P
--
E
A
W
-----------
T
N
E
---
Q
L
F
S
-
A
G
L
----
E
R
-----
A
L
S
V
E
T
V
R
A
A
F
T
G
A
PP-
G
---
P
W
H
E
K
L
R
R
R
F
------
A
S
L
PIK
T
K
-
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
-----
65
Fugue
67.70
22%
23
- C3 -
-
3AQL
1
?
A:
[1-411]
QVTVIPREQHAISRKDISEN
A
L
K
V
M
Y
R
L
N
K
A
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
-
D
V
T
T
N
A
T
P
E
Q
V
----
R
K
L
F
R
N
C
R
L
------
V
------
G
R
--------
R
F
R
---
L
-
A
--
H
---
V
------------
M
F
G
P
E
I
I
-
E
--
V
A
T
------------
F
R
G
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
LIG
N
P
-
E
-
T
---
R
---
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
T
E
N
G
D
S
P
M
E
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
M
-----
R
-------------------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
--------
P
L
L
E
T
A
Q
K
I
A
---
Q
E
S
G
--
L
T
Y
H
D
A
F
-
A
L
A
M
N
D
V
L
D
E
--
A
C
R
-----------------
S
L
A
I
--
P
K
R
--
L
T
------
T
L
T
R
D
I
W
Q
L
Q
L
R
M
S
R
-
R
Q
G
K
R
A
W
K
L
L
E
H
--------------------------
P
K
F
------
R
A
A
---
Y
D
-
L
L
A
L
R
-
A
E
V
-
E
---
R
N
A
-
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--------
2
PsiBlast_PDB
67.48
29%
5
- C3 -
-
3H3A
1
?
A:
[35-350]
--------------------------------
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
---
N
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
---
Y
A
--
K
R
F
L
P
-------------
G
K
L
V
K
HDKFM
T
A
S
---
L
F
L
--
K
---
G
------------
G
L
R
I
D
I
A
-
T
--
A
----------------------------
E
------
M
-
S
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
K
-
L
-
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
---
V
L
H
T
-
L
---
S
---
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
---
D
F
R
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
F
P
----------
K
T
Y
Y
T
P
S
M
D
E
K
M
E
N
L
F
R
N
I
P
W
V
E
-----
E
-------------------------
N
F
G
E
V
D
R
F
Y
A
V
L
H
V
F
L
EFYDD
E
S
W
K
E
V
R
D
R
Y
---
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
A
L
L
E
M
L
S
E
R
V
P
A
S
F
V
Y
P
L
V
K
G
V
S
---
N
E
T
I
-
C
--
H
--------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
65.98
25%
38
- C3 -
-
4X4W
3
TRNT1_HUMAN
A:
[1-409]
--M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
FT
E
G
L
K
S
L
T
E
L
F
V
K
E
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
---
P
Q
D
I
D
F
A
T
-
T
A
T
P
T
Q
M
K
E
M
F
Q
S
--
A
G
I
R
M
------
I
------
N
G
--------
T
I
T
---
A
R
L
--
H
---
E
------------
E
N
F
E
I
T
T
-
L
--
R
I
D
V
T
T
D
G
A
-------
E
V
E
---
F
------
T
------
T
-
D
-
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
G
-
F
-
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
FVG
H
A
-
K
-
Q
---
R
---
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
D
K
P
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
K
G
--
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
--------
G
L
P
A
N
A
-----------
S
L
E
E
F
D
K
V
S
K
-----
N
-------------------------
V
D
G
F
S
P
K
P
V
T
L
L
A
--------
S
L
F
K
V
Q
---------------------
D
D
V
T
K
L
D
L
R
L
--
K
I
A
K
E
-
E
K
N
L
G
L
F
I
V
---
K
N
R
------
K
D
--
L
I
------
K
A
T
D
S
S
D
P
L
K
P
Y
Q
D
F
I
I
D
S
D
A
T
T
R
V
C
E
L
L
K
Y
Q
G
E
H
C
L
L
K
E
---
M
---
Q
Q
W
S
-
I
P
P
F
P
------
V
S
G
---
H
D
-
I
R
K
----
V
G
-
I
S
S
-
G
K
E
-
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
45
HHSearch
65.83
24%
-11
- C3 -
-
3AQK
-
?
A:
[50-402]
---------------------------------
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
-
N
A
T
P
E
Q
V
----
R
K
--
L
F
R
N
C
R
L
----
V
------
G
R
--------
R
F
R
---
L
A
H
--
V
M
F-
G
------------
P
E
I
I
E
V
A
-
T
--
F
R
----------------
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
-
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
---
L
I
-
G
-
N
P
E
T
R
---
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
T
E
N
G
D
S
P
M
E
------
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
M
-------------------------
R
V
N
P
A
F
L
F
A
A
M
F
W
Y
-------
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
D
A
F
A
L
A
M
N
-
D
V
L
D
E
A
C
R
S
L
--
A
I
P
K
R
-
L
T
T
L
T
R
D
I
W
---
Q
L
Q
L
R
M
--
S
R
R
--
Q
---------
G
K
R
A
W
K
L
L
E
H
P
K
F
---
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
----------------------------------------------------------------------------------------
49
HHSearch
65.72
25%
30
- C3 -
-
4X4W
2
TRNT1_HUMAN
A:
[32-400]
---------------------------------
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
---
P
Q
D
I
D
F
A
T
T
-
A
T
P
T
Q
M
----
K
E
--
M
F
Q
S
A
G
I
R
M
I
N-------------------
G
---
T
I
T
A
R
L
---
H
------------
E
E
N
F
E
I
T
-
T
--
L
R
I
D
V
T
T
-
D
G
---
A
--
E
V
E
---
F
------
T
------
T
-
D
-
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
G
-
F
-
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
---
F
V
-
G
H
A
K
Q
-
R
---
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
D
K
P
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
G
L
P
A
N
-----------
A
S
-
L
E
E
F
D
K
V
S
K
N
V
D
---
G
-----
F
-------------------------
S
P
K
P
V
T
L
L
A
S
L
F
K
--------
V
Q
D
D
V
-------------------------
T
K
L
D
L
R
L
--
K
I
A
K
E
-
E
K
N
L
G
L
F
I
V
---
K
N
R
K
D
L
--
I
K
A
--
T
D
S-----
S
D
P
L
K
P
Y
Q
--
D
------------
F
I
I
D
S
---
D
A
T
T
R
V
C
E
L
L
K
Y
Q
---
G
E
H
C
-
L
L
K
E
M
------
Q
Q
W
---
S
I
-
P
P
F
P
V
-
S
G
H
D
I
R
K
-
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
-----
17
PsiBlast_PDB
64.46
31%
-11
- C3 -
-
3AQM
-
?
A:
[34-256]
---------------------------------
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
-
V
T
T
N
A
T
P
E
Q
V
R
K
--
L
F
--
R
N
C
R
L
------
V
------
G
R
--------
R
F
R
L
A
H
V
M
F
--
G
---
P
------------
E
I
I
E
V
A
T
-
F
RG------------------
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
---
L
I
-
G
-
N
---
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
---
L
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
T
L
--
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
64.21
23%
-
- C3 -
-
4X0A
-
?
A:
[12-381]
---------------------------------
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
-
G
N
A
I
E
L
----
A
K
--
E
L
A
R
R
------
H
G
V
N
V
H
P
F
P
--------
E
F
G
---
T
A
H
--
L
K
I
-
G
------------
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
---
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
I
E
G
F
Q
W
N
E
K
V
L
Q
K
-
L
Y
A
L
R
K
V
V
D
W
H
A
L
E
F
S
E
E
R
---------------------------------
I
D
Y
G
W
L
Y
L
L
I
L
I
S
--------
N
L
D
Y
-----------------------
E
R
G
K
H
F
L
E
E
M
--
S
A
P
S
W
-
V
R
E
T
Y
K
F
M
K
---
F
K
L
G
S
L
K
E
E
L
K
--
K
A
------
K
E
N
Y
E
V
Y
R
L
L
K
P
L
H
T
----
S
V
L
---
L
L
L
M
L
-
E
E
E
L
K
-------------
E
K
-
I
K
L
Y
L
------
E
K
L
---
R
K
-
V
K
L
P
K
E
K
I
E
E
L
K
K
-----
G
K
E
-
L
G
E
R
I
E
E
L
K
R
E
I
M
N
--------------
20
PsiBlast_PDB
63.81
30%
-11
- C3 -
-
3AQN
1
?
A:
[34-256]
---------------------------------
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
-
V
T
T
N
A
T
P
E
Q
V
R
K
--
L
F
--
R
N
C
R
L
------
V
------
G
R
--------
R
F
R
L
A
H
V
M
F
--
G
---
P
------------
E
I
I
E
V
A
T
-
F
R
G------------------
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
---
L
I
-
G
-
N
---
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
---
L
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
T
L
--
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
63.35
23%
16
- C3 -
-
4WBY
1
?
A:
[26-396]
---------------------------------
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
-
G
N
A
I
E
L
----
A
K
--
E
L
A
R
R
------
H
G
V
N
V
H
P
F
P
--------
E
F
G
---
T
A
H
--
L
K
I
-
G
------------
K
L
K
L
E
F
A
-
T
--
A
R
R
E
-------------------------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
---
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
I
E
G
F
Q
W
N
E
K
V
L
Q
K
-
L
Y
A
L
R
K
V
V
D
W
H
A
L
E
F
S
E
E
R
---------------------------------
I
D
Y
G
W
L
Y
L
L
I
L
I
S
--------
N
L
D
Y
-----------------------
E
R
G
K
H
F
L
E
E
M
--
S
A
P
S
W
-
V
R
E
T
Y
K
F
M
K
---
F
K
L
G
S
L
K
E
E
L
K
--
K
A
------
K
E
N
Y
E
V
Y
R
L
L
K
P
L
H
T
----
S
V
L
---
L
L
L
M
L
-
E
E
E
L
K
-------------
E
K
-
I
K
L
Y
L
------
E
K
L
---
R
K
-
V
K
-------------
G
L
K
G
K
E
-
L
G
E
R
I
E
E
L
K
R
E
I
M
N
K
-------------
22
PsiBlast_CBE
62.55
33%
-23
- C3 -
-
4WC0
1
?
B:
[11-223]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
FPEFGTAHLKIG
K
L
K
L
E
F
A
-
T
--
A
R
R
E
-------------------------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.53
33%
-15
- C3 -
-
4WC0
1
?
A:
[11-209]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
-------------------------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.26
30%
-13
- C3 -
-
3AQL
1
?
A:
[34-256]
---------------------------------
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
-
V
T
T
N
A
T
P
E
Q
V
R
K
--
L
F
--
R
N
C
R
L
------
V
------
G
R
--------
R
F
R
L
A
H
V
M
F
--
G
---
P
------------
E
I
I
E
V
A
T
-
F
RG------------------
N
---
I
------
F
------
G
-
S
-
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
---
L
I
-
G
-
N
---
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
---
L
G
M
R
I
S
P
E
T
A
E
P
I
P
R
L
A
T
L
--
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.02
33%
-14
- C3 -
-
4WC1
1
?
A:
[11-209]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
-------------------------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.50
33%
-9
- C3 -
-
4WC5
1
?
A:
[11-207]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.78
33%
-13
- C3 -
-
4WC1
1
?
B:
[11-223]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
FPEFGTAHLKIG
K
L
K
L
E
F
A
-
T
--
A
R
R
E
-------------------------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.33
33%
-6
- C3 -
-
4WC2
1
?
A:
[11-207]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.25
33%
-8
- C3 -
-
4WC4
1
?
A:
[11-207]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.23
33%
-6
- C3 -
-
4WC6
1
?
A:
[11-207]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.98
33%
-8
- C3 -
-
4WC7
1
?
A:
[11-207]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
PEFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-----------------
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.61
38%
-35
- C3 -
-
1MIY
1
CCA_GEOSE
A:
[23-180]
-----------------------------------
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
-
I
A
T
S
A
L
P
E
D
V
----
M
A
--
I
----------------------------
F
P
---
K
T
I
--
D
---
V
------------
G
S
K
H
G
T
V
-
V
--
V
V
---
H
K
G
K
A
Y
E
V
T
T
F
K
T
D
GS
V
T
------
F
------
V
R
S
-
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
---
T
V
-
G
-
E
---
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
---
L
G
F
A
L
A
P
D
T
E
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.14
38%
-35
- C3 -
-
1MIY
1
CCA_GEOSE
B:
[23-180]
-----------------------------------
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
-
I
A
T
S
A
L
P
E
D
V
----
M
A
--
I
----------------------------
F
P
---
K
T
I
--
D
---
V
------------
G
S
K
H
G
T
V
-
V
--
V
V
---
H
K
G
K
A
Y
E
V
T
T
F
K
T
D
GSV
T
------
F
------
V
R
S
-
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
---
T
V
-
G
-
E
---
A
EKR
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
---
L
G
F
A
L
A
P
D
T
E
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.00
33%
-4
- C3 -
-
1VFG
1
?
A:
[11-203]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
F
P
EFG
T
A
H
L
K
I
G
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-------------
V
---
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
58.80
33%
-5
- C3 -
-
1VFG
1
?
B:
[11-226]
--------------------------------
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
------
L
A
-----
K
E
------
L
------
A
R
--------
R
H
G
---
V
N
V
--
H
---
P
FPEFGTAHLKIG
K
L
K
L
E
F
A
-
T
--
A
R
R
E
T
-------------
V
---
E
------
P
------
A
-
S
-
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
-
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
---
V
L
-
H
-
P
V--
S
---
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
---
L
N
F
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------