@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01126_HMOX1_: (2014-09-20 )
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90.......-.100.......110.......120......-.130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MERPQPDS
M
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
HTQAE
N
A
E
F
M
R
N
F
QKGQVT
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
RNKESP
V
F
APVY
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
WYG-P
R
W
Q
EVIPY
T
P
A
M
Q
R
Y
V
K
R
L
H
E
VGRTE
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
GDLS
G
G
Q
V
L
K
K
I
A
Q
K
A
LDLPSSGE
G
L
A
F
F
TFPNI
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
NSLEM
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
THDTKDQSPSRAP
G
L
R
Q
R
ASNKVQDSAPVETPRGKPPLNTRSQ
A
P
L
L
R
W
V
L
T
L
S
F
L
V
A
T
V
A
V
GLYAM
25
PsiBlast_CBE
97.29
100%
-116
- C5 -
1TWR
2
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
29
PsiBlast_CBE
96.54
100%
-114
- C5 -
1OZW
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
31
PsiBlast_CBE
96.47
100%
-116
- C5 -
1N45
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
38
PsiBlast_CBE
96.37
99%
-116
- C5 -
1OYL
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
30
PsiBlast_CBE
96.31
100%
-114
- C5 -
1OZR
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
7
PsiBlast_PDB
96.28
100%
-112
- C5 -
1TWN
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
36
PsiBlast_CBE
96.23
99%
-117
- C5 -
1OZL
2
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
9
PsiBlast_PDB
96.16
100%
-115
- C5 -
3CZY
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
42
PsiBlast_CBE
96.13
99%
-117
- C5 -
1XK1
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
H
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
21
PsiBlast_CBE
96.13
100%
-118
- C5 -
3TGM
2
HMOX1_HUMAN
B:
[10-224]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
D
----------------------------------------------------------------
11
PsiBlast_PDB
96.10
100%
-114
- C5 -
3K4F
3
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
34
PsiBlast_CBE
96.04
99%
-115
- C5 -
1XK3
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
5
PsiBlast_PDB
96.02
100%
-116
- C5 -
1S8C
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
62
Fugue
95.98
100%
-115
- C5 -
1N45
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
24
PsiBlast_CBE
95.95
100%
-116
- C5 -
3CZY
2
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
22
PsiBlast_CBE
95.77
100%
-115
- C5 -
3K4F
3
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
17
PsiBlast_PDB
95.77
99%
-113
- C5 -
1OYL
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
26
PsiBlast_CBE
95.71
100%
-116
- C5 -
1TWN
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
19
PsiBlast_PDB
95.41
99%
-112
- C5 -
1OZL
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
3
PsiBlast_PDB
95.40
100%
-111
- C5 -
1OZR
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
32
PsiBlast_CBE
95.35
100%
-113
- C5 -
1N3U
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
8
PsiBlast_PDB
95.33
100%
-111
- C5 -
1TWR
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
1
PsiBlast_PDB
95.27
100%
-112
- C5 -
1N3U
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
41
PsiBlast_CBE
95.20
99%
-112
- C5 -
1XK1
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
H
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
18
PsiBlast_PDB
95.16
99%
-113
- C5 -
1OZE
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
28
PsiBlast_CBE
95.15
100%
-116
- C5 -
1S13
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
4
PsiBlast_PDB
95.08
100%
-113
- C5 -
1OZW
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
40
PsiBlast_CBE
95.05
99%
-114
- C5 -
1XK0
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
A
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
12
PsiBlast_PDB
95.04
100%
-114
- C5 -
3TGM
3
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
15
PsiBlast_PDB
95.02
99%
-109
- C5 -
1XK3
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
35
PsiBlast_CBE
94.97
99%
-112
- C5 -
1XK2
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
37
PsiBlast_CBE
94.89
99%
-113
- C5 -
1OZE
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
14
PsiBlast_PDB
94.89
99%
-110
- C5 -
1XK2
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
20
PsiBlast_PDB
94.88
99%
-118
- C5 -
1XK0
2
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
A
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
E
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
16
PsiBlast_PDB
94.87
99%
-115
- C5 -
1OYK
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
10
PsiBlast_PDB
94.79
100%
-113
- C5 -
3HOK
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
13
PsiBlast_PDB
94.76
99%
-118
- C5 -
1XJZ
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
A
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
6
PsiBlast_PDB
94.76
100%
-117
- C5 -
1S13
1
HMOX1_HUMAN
A:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
33
PsiBlast_CBE
94.63
99%
-113
- C5 -
1XJZ
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
A
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
39
PsiBlast_CBE
94.42
99%
-114
- C5 -
1OYK
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
A
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
23
PsiBlast_CBE
91.70
100%
-111
- C5 -
3HOK
2
HMOX1_HUMAN
B:
[9-223]
--------
M
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
53
PsiBlast_CBE
91.01
80%
-109
- C5 -
4G7P
3
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
49
PsiBlast_CBE
90.75
80%
-112
- C5 -
4G8U
3
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
48
PsiBlast_CBE
90.72
80%
-110
- C5 -
4G8W
5
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
54
PsiBlast_CBE
90.53
80%
-111
- C5 -
4G7L
3
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
71
HHSearch
90.32
79%
-109
- C5 -
1J02
3
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
50
PsiBlast_CBE
90.23
80%
-108
- C5 -
4G8P
3
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
27
PsiBlast_CBE
89.97
100%
-115
- C5 -
1T5P
1
HMOX1_HUMAN
B:
[10-223]
---------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
----------------
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-----------------------------------------------------------------
57
PsiBlast_CBE
89.88
80%
-109
- C5 -
2ZVU
2
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
52
PsiBlast_CBE
89.85
80%
-108
- C5 -
4G7T
3
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
45
PsiBlast_CBE
89.83
79%
-108
- C5 -
3I9T
2
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
44
PsiBlast_CBE
89.82
79%
-108
- C5 -
3I9U
2
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
60
PsiBlast_CBE
89.75
80%
-109
- C5 -
1VGI
2
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
46
PsiBlast_CBE
89.69
80%
-107
- C5 -
4G99
3
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
58
PsiBlast_CBE
89.66
80%
-108
- C5 -
2E7E
1
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
51
PsiBlast_CBE
89.42
80%
-108
- C5 -
4G7U
3
HMOX1_RAT
A:
[11-223]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
47
PsiBlast_CBE
89.40
80%
-106
- C5 -
4G98
3
HMOX1_RAT
A:
[11-222]
----------
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
------------------------------------------------------------------
59
PsiBlast_CBE
88.82
80%
-106
- C5 -
2DY5
2
HMOX1_RAT
A:
[10-223]
---------
S
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-----------------------------------------------------------------
73
HHSearch
79.99
50%
-107
* C5 *
2Q32
1
HMOX2_HUMAN
A:
[29-241]
--------
R
M
A
D
L
S
E
L
L
K
E
G
T
K
E
A
H
D
R
A
E
N
T
Q
F
V
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
E
R
N
K
D
H
P
A
F
A
P
L
Y
F
P
M
E
L
H
R
K
E
A
L
T
K
D
M
E
Y
F
F
G
-
E
N
W
E
E
Q
V
Q
A
P
K
A
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
K
K
V
A
Q
R
A
L
K
L
P
S
T
G
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
N
E
L
D
Q
A
G
-------------------------------------------------------------------
74
HHSearch
73.66
42%
-99
- C5 -
1WE1
3
HO1_SYNY3
A:
[2-223]
---------
S
V
N
L
A
S
Q
L
R
E
G
T
K
K
S
H
S
M
A
E
N
V
G
F
V
K
C
F
L
K
G
V
V
E
K
N
S
Y
R
K
L
V
G
N
L
Y
F
V
Y
S
A
M
E
E
E
M
A
K
F
K
D
H
P
I
L
S
H
I
Y
F
P
-
E
L
N
R
K
Q
S
L
E
Q
D
L
Q
F
Y
Y
G
-
S
N
W
R
Q
E
V
K
I
S
A
A
G
Q
A
Y
V
D
R
V
R
Q
V
A
A
T
A
P
E
L
-
L
V
A
H
S
Y
T
R
Y
L
G
D
L
S
G
G
Q
I
L
K
K
I
A
Q
N
A
M
N
L
H
D
G
--
G
T
A
F
Y
E
F
A
D
I
D
D
E
K
A
F
K
N
T
Y
R
Q
A
M
N
D
L
P
I
D
Q
A
T
A
E
R
I
V
D
E
A
N
D
A
F
A
M
N
M
K
M
F
N
E
L
E
G
N
L
I
K
A
I
G
I
M
V
F
N
S
L
T
------------------------------------------------------
75
HHSearch
69.24
34%
-100
- C5 -
1WZD
3
HMUO_CORDI
A:
[7-214]
-----------
G
L
A
V
E
L
K
Q
S
T
A
Q
A
H
E
K
A
E
H
S
T
F
M
S
D
L
L
K
G
R
L
G
V
A
E
F
T
R
L
Q
E
Q
A
W
L
F
Y
T
A
L
E
Q
A
V
D
A
V
R
A
S
G
F
A
E
S
L
L
D
P
-
A
L
N
R
A
E
V
L
A
R
D
L
D
K
L
N
G
S
S
E
W
R
S
R
I
T
A
S
P
A
V
I
D
Y
V
N
R
L
E
E
I
R
D
N
V
D
G
P
A
L
V
A
H
H
Y
V
R
Y
L
G
D
L
S
G
G
Q
V
I
A
R
M
M
Q
R
H
Y
G
V
D
--
P
E
A
L
G
F
Y
H
F
E
G
I
A
K
L
K
V
Y
K
D
E
Y
R
E
K
L
N
N
L
E
L
S
D
E
Q
R
E
H
L
L
K
E
A
T
D
A
F
V
F
N
H
Q
V
F
A
D
L
G
K
G
--------------------------------------------------------------------