@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0206: (2015-12-13 )
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIITTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITADQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRVHRVPNTTLISVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRLRNISSSY
Atome Classification :
(29 SA)
.........10........20.......--.30......-..40........50........60........70........80------------....--.-..-----..-90----..--.-.-.....100.......110..-.-..-..120......-.130.......140--..--.....150.......160.....----..170----------.----------.--.....180.......190.......200.......210.......-------220-..-------...----...230--........240.......250....-...260.......270.......280-........-290---..---------......300...--....310...-....320.......330..-......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
Q
R
I
Y
LDNNATTRI
D
P
K
V
K
E
I
M
D
P
F
L
R
--DHYG
N
P
S
S
L
-
H
Q
FGTE
T
H
P
A
I
A
E
A
L
D
K
L
Y
KGINARD
I
D
D
V
I
I
T
S
CATESN
N
W
V
-------------
L
K
G
V
--
Y
-
F
D
-----
E
C
-
L
-----KK--G-K-N
H
I
I
T
TVAEHP
A
V
R
S
T
C
N
F
L
-
E
-SL-G
V
E
V
T
Y
L
P
INE-HGSI
T
A
D
Q
V
K
E
A
I
T--EK--
T
A
L
V
S
V
M
WANNET
G
L
I
F
P
I
E
E
I
G
----
A
I
C
K
E----------K----------
G
--
V
L
F
H
T
D
A
V
Q
A
I
G
KI
P
V
D
V
L
KANV
D
F
L
SFSAHKFHGPKGI
G
G
L
Y
I
R-------SG--VG-------LTP----LFHGG---EHMNGRRSGTLNV
P
Y
I
VGM
G
E
A
M
K
L
-
A
V
E
HLD
Y
E
K
E
V
V
G
K
L
R
D
K
L
E
E
A
L
L
-K-IP
D
V
M
V
VG-
D
R
----VH---------RVPN
T
T
L
I
S
V
RG--IEG
E
A
M
L
W
DL-NRSNIAASTGSACASE-DL-EAN
P
V
M
V
A
IGAS
K
E
L
A
H
T
A
I
R
L
S
L
S
RFNT
E
A
E
I
D
K
T
I
E
V
F
S
Q
A
A
V
R
L
R
NISSSY
1
PsiBlast_PDB
93.09
43%
-96
- C2 -
3LVJ
2
ISCS_ECO57
A:
[24-403]
----
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
-------------
I
K
G
A
----
A
N
-----
F
Y
-
Q
-----
K
K
--
G
-
K
--
H
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
-
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
--
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
----
E
M
C
R
A
----------
R
----------
G
--
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
P
R
V
R
-------
I
E
A
----
Q
M
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
-
D
-
I
E
E
V
Y
L
N
G
-
D
L
----
E
H
---------
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
-------
S
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
W
21
PsiBlast_CBE
92.36
43%
-93
- C2 -
3LVJ
2
ISCS_ECO57
B:
[24-403]
----
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
-------------
I
K
G
A
----
A
N
-----
F
Y
-
Q
-----
K
K
--
G
-
K
--
H
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
-
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
--
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
----
E
M
C
R
A
----------
R
----------
G
--
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
PR
V
R
-------
I
E
A
----
Q
M
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
-
D
-
I
E
E
V
Y
L
N
G
-
D
L
----
E
H
---------
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
W
87
HHSearch
91.89
43%
-97
* C2 *
1EG5
3
?
A:
[2-376]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
-------------
L
K
T
V
--
A
-
E
T
------
F
--------
E
--
K
R
K
-
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
-
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
----
R
I
V
K
K
----------
K
NK--------
E
--
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
--
V
P
-------
I
R
P
----
L
I
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
-
N
-
L
-
G
A
H
I
I
T
-
P
L
----
E
I
---------
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
-------
2
PsiBlast_PDB
91.13
43%
-94
- C2 -
3LVK
1
ISCS_ECO57
A:
[24-403]
----
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
-------------
I
K
G
A
----
A
N
-----
F
Y
-
Q
-----
K
K
--
G
-
K
--
H
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
-
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
--
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
----
E
M
C
R
A
----------
R
----------
G
--
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
P
R
V
R
-------
I
E
A
----
Q
M
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
-
D
-
I
E
E
V
Y
L
N
G
-
D
L
----
E
H
---------
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
W
110
Fugue
90.59
43%
-94
- C2 -
1ECX
2
?
A:
[1-376]
--
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
-------------
L
K
T
V
--
A
-
E
T
-----
F
--------
E
K
--
R
-
K
-
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
-
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
----
R
I
V
K
K
----------
K
----------
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
--
V
P
-------
I
R
P
----
L
I
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
-
N
--
L
G
A
H
I
I
T
-
P
L
----
E
I
---------
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
H
--------------
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
-------
111
Fugue
90.49
38%
-92
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
---
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
---
T
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
-
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
-------------
V
K
G
I
--
Y
-
W
A
-----
R
R
-
D
-----
A
E
--
P
H
R
-
R
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
-
V
-
E
H
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
--
S
H
DD
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
----
V
V
A
M
E
----------
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
--
V
T
-------
C
V
P
----
L
M
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
-
A
E
I
D
D
V
C
L
N
G
A
D
D
----
P
M
---------
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
P
----------
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
-
7
PsiBlast_PDB
89.11
37%
-90
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[3-378]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
-------------
I
I
G
---
Y
-
A
M
-----
R
N
-
A
-----
R
K
--
G
-
K
--
H
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
-
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
----
E
V
L
A
G
----------
K
----------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
--
A
K
-------
L
Q
P
----
V
I
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
-
I
E
E
S
Y
L
N
G
-
H
P
----
E
K
---------
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
--
6
PsiBlast_PDB
89.08
37%
-87
- C2 -
4EB7
7
ISCS2_ARCFU
A:
[3-380]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
-------------
I
I
G
---
Y
-
A
M
-----
R
N
-
A
-----
R
K
--
G
-
K
--
H
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
-
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
----
E
V
L
A
G
----------
K
----------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
--
A
K
-------
L
Q
P
----
V
I
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
-
I
E
E
S
Y
L
N
G
-
H
P
----
E
K
---------
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
--
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
L
Y
25
PsiBlast_CBE
88.64
38%
-90
- C2 -
4ISY
1
ISCSL_MYCTU
D:
[14-385]
-----
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
-
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
-------------
V
K
G
I
--
Y
-
W
A
-----
R
R
D
A
-----
E
P
--
H
-
R
-
R
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
SH
D
D
--
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
----
V
V
A
M
E
----------
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
--
V
T
-------
C
V
P
----
L
M
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
L
N
G
A
D
D
----
P
M
---------
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
A
3
PsiBlast_PDB
88.60
44%
-94
- C2 -
1ECX
2
?
A:
[2-363]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
-------------
L
K
T
V
-----
A
-----
E
T
-
F
-----
E
K
--
R
-
K
-
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
-
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
----
R
I
V
K
K
----------
K
----------
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
--
V
P
-------
I
R
P
----
L
I
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
-
N
-
L
G
A
H
I
I
T
P
-
L
E
----
I
S
----------
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
-------
4
PsiBlast_PDB
88.44
43%
-92
- C2 -
1EG5
3
?
A:
[2-363]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
-------------
L
K
T
V
-----
A
-----
E
T
-
F
-----
E
K
--
R
-
K
-
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
-
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
----
R
I
V
K
K
----------
K
----------
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
--
V
P
-------
I
R
P
----
L
I
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
-
N
-
L
G
A
H
I
I
T
P
-
L
E
----
I
S
----------
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
-------
5
PsiBlast_PDB
88.40
37%
-90
- C2 -
4EB5
6
ISCS2_ARCFU
A:
[3-380]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
-------------
I
I
G
---
Y
-
A
M
-----
R
N
-
A
-----
R
K
--
G
-
K
--
H
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
-
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
----
E
V
L
A
G
----------
K
----------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
--
A
K
-------
L
Q
P
----
V
I
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
-
I
E
E
S
Y
L
N
G
-
H
P
----
E
K
---------
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
L
Y
23
PsiBlast_CBE
87.57
37%
-89
- C2 -
4EB7
4
ISCS2_ARCFU
B:
[3-378]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
-------------
I
I
G
---
Y
-
A
M
-----
R
N
-
A
-----
R
K
--
G
-
K
--
H
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
-
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
----
E
V
L
A
G
----------
K
----------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
--
A
K
-------
L
Q
P
----
V
I
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
-
I
E
E
S
Y
L
N
G
-
H
P
----
E
K
---------
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
--
8
PsiBlast_PDB
87.08
38%
-90
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[14-385]
-----
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
-
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
-------------
V
K
G
I
--
Y
-
W
A
-----
R
R
D
A
-----
E
P
--
H
-
R
-
R
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
--
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
----
V
V
A
M
E
----------
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
--
V
T
-------
C
V
P
----
L
M
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
L
N
G
A
D
D
----
P
M
---------
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
-
22
PsiBlast_CBE
86.99
44%
-93
- C2 -
1ECX
2
?
B:
[2-363]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
-------------
L
K
T
V
-----
A
-----
E
T
-
F
-----
E
K
--
R
-
K
-
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
-
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
----
R
I
V
K
K
----------
K
----------
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
--
V
P
-------
I
R
P
----
L
I
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
-
N
-
L
G
A
H
I
I
T
P
-
L
E
----
I
S
----------
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
-------
24
PsiBlast_CBE
86.79
37%
-94
- C2 -
4EB5
5
ISCS2_ARCFU
B:
[3-378]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
-------------
I
I
G
---
Y
-
A
M
-----
R
N
-
A
-----
R
K
--
G
-
K
--
H
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
-
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
----
E
V
L
A
G
----------
K
----------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
--
A
K
-------
L
Q
P
----
V
I
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
-
I
E
E
S
Y
L
N
G
-
H
P
----
E
K
---------
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
--
27
PsiBlast_CBE
86.68
38%
-87
- C2 -
4ISY
2
ISCSL_MYCTU
B:
[14-385]
-----
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
-
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
-------------
V
K
G
I
--
Y
-
W
A
-----
R
R
D
A
-----
E
P
--
H
-
R
-
R
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
--
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
----
V
V
A
M
E
----------
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
--
V
T
-------
C
V
P
----
L
M
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
L
N
G
A
D
D
----
P
M
---------
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
--
26
PsiBlast_CBE
86.45
38%
-89
- C2 -
4ISY
3
ISCSL_MYCTU
C:
[14-385]
-----
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
-
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
-------------
V
K
G
I
--
Y
-
W
A
-----
R
R
D
A
-----
E
P
--
H
-
R
-
R
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
SH
D
D
--
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
----
V
V
A
M
E
----------
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
--
V
T
-------
C
V
P
----
L
M
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
L
N
G
A
D
D
----
P
M
---------
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
A
---------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
A
9
PsiBlast_PDB
84.34
34%
-85
- C2 -
3GZC
2
SCLY_HUMAN
A:
[25-438]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
--
E
A
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
-------------
I
H
S
V
V
K
H
-
F
H
A
N
Q
T-----------
G
--
A
-
K
-
P
H
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
E
Q
-
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
--
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
K
A
L
N
Q
E
----------
R
V
A
A
G
L
P
----
P
--
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
--------
G
--
L
G
EF
T
P
---
L
Y
P
----
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
-
V
T
Q
N
C
E
A
Y
E
A
H
M
R
D
V
R
D
Y
L
E
E
R
L
------
E
A
E
F
G
Q
-
K
R
----
I
H
LNSQFPGTQ
R
L
P
N
T
C
N
F
S
I
R
G
PR
L
Q
G
H
V
V
L
A
Q
C
-
R
V
--
L
M
A
S
V
G
A
A
C
H
S
D
-
H
G
D
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
E
D
Q
----
32
PsiBlast_CBE
83.69
33%
-88
- C2 -
3GZD
3
SCLY_HUMAN
B:
[26-438]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
--
E
A
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
-------------
I
H
S
V
VK
H
-
F
H
ANQTS----------
G
--
A
-
K
-
P
H
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
E
Q
-
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
--
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
QRIK
A
L
N
Q
E
----------
R
VAAGLP----
P
--
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
--------
G
--
L
G
EFTP---
L
Y
P
----
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
-
V
T
Q
N
C
E
A
Y
E
A
H
M
R
D
V
R
D
Y
L
E
E
R
L
------
E
A
E
F
G
Q
-
K
R
----
I
H
LNSQFPGTQ
R
L
P
N
T
C
N
F
S
I
R
G
PR
L
Q
G
H
V
V
L
A
Q
C
-
R
V
--
L
M
A
S
V
G
----------
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
E
D
-----
30
PsiBlast_CBE
83.23
35%
-77
- C2 -
3A9Y
4
SCLY_RAT
B:
[18-428]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q-----------------------------
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
--------
G
--
V
G
K------
L
T
P
L
Y
P
M
L
F
G
G
G
---
Q
E
R
N
-
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
-------
E
A
E
F
G
-
K
R
----
I
H
LNSRFPGVE
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
---
29
PsiBlast_CBE
83.22
35%
-77
- C2 -
3A9Z
3
SCLY_RAT
B:
[18-428]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q------------------------------
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
--------
G
--
V
G
K------
L
T
P
L
Y
P
M
L
F
G
G
G
---
Q
E
R
N
-
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
-------
E
A
E
F
G
-
K
R
----
I
H
LNSRFPGVE
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
---
31
PsiBlast_CBE
82.99
35%
-76
- C2 -
3A9X
5
SCLY_RAT
B:
[18-428]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
--------------------------
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
--------
G
--
V
G
K------
L
T
P
L
Y
P
M
L
F
G
G
G
---
Q
E
R
N
-
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
-------
E
A
E
F
G
-
K
R
----
I
H
LNSRFPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
------
11
PsiBlast_PDB
82.87
35%
-77
- C2 -
3A9X
3
SCLY_RAT
A:
[18-428]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
G
-----------------------EG
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
--------
G
--
V
G
K------
L
T
P
L
Y
P
M
L
F
G
G
G
---
Q
E
R
N
-
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
-------
E
A
E
F
G
-
K
R
----
I
H
LNSRFPGVE
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
--------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
---
12
PsiBlast_PDB
82.43
35%
-80
- C2 -
3A9Z
5
SCLY_RAT
A:
[18-428]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
--------------------------
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
L
N
Q
I
R
A
A
S
GL
P
----------
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
--------
G
--
V
G
K------
L
T
P
L
Y
P
M
L
F
G
G
G
---
Q
E
R
N
-
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
-------
E
A
E
F
G
-
K
R
----
I
H
LNSRFPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
---
94
HHSearch
82.38
36%
-76
- C2 -
3A9Z
5
SCLY_RAT
A:
[18-431]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
-------------
I
H
S
T
--
V
-
R
C
-----
F
H
-
E
Q
Q
T
L
Q----
T
-
R
-
P
H
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
----
R
R
I
K
A
----------
L
N
Q
I
R
A
A
S
GL
P
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
-------
G
V
--
G
K
-------
L
T
P
----
L
Y
P
M
L
FGG
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
-
A
-
E
F
G
K
R
I
H
L
-
N
S
RFPG
V
E
---------
R
L
P
N
T
C
N
F
S
I
Q
G
--
S
Q
L
R
-
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
-
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
---
33
PsiBlast_CBE
78.47
34%
-82
- C2 -
3VAX
2
?
B:
[23-379]
-----
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
-------------
L
L
G
L
--
A
P
Y
G
-----
E
--------
R
T
--
G
-
R
-
R
H
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
-
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
--
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
----
Q
Q
L
R
A
----------
T
----------
P
--
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
-
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
RREEMDD
E
R
--
V
P
-------
L
E
P
----
I
M
F
G
G
---
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
-
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
-
S
-
T
-
S
F
Q
V
N
G
-
D
Q
----
D
H
---------
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
--
K
D
L
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
---
W
T
P
G
------------------------
14
PsiBlast_PDB
78.09
34%
-84
- C2 -
3VAX
1
?
A:
[23-379]
-----
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
-------------
L
L
G
L
--
A
P
Y
G
-----
E
--------
R
T
--
G
-
R
-
R
H
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
-
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
--
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
----
Q
Q
L
R
A
----------
T
----------
P
--
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
-
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
R
R
EEMDD
E
R
--
V
P
-------
L
E
P
----
I
M
F
G
G
---
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
-
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
-
S
-
T
-
S
F
Q
V
N
G
-
D
Q
----
D
H
---------
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
--
K
D
L
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
---
W
T
P
G
------------------------
89
HHSearch
76.89
33%
-87
- C2 -
3VAX
1
?
A:
[22-379]
----
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
-------------
L
L
G
L
--
A
-
P
Y
-----
G
E
--------
R
--
T
-
G
R
R
H
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
-
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
--
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
----
Q
Q
L
R
A
----------
T
----------
P
--
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
-------
R
R
--
E
E
MDDERVP
L
E
P
----
I
M
F
G
G
---
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
-
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
-
S
-
T
-
S
F
Q
V
N
G
-
D
Q
----
D
H
---------
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
-
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
---------------------------