@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0742: (2016-03-18 )
MLVGNNIAKSYPNKLVLQNVDFEAKSGDMIVLTGENGSGKTTLLDMLASLKKPDSGTLELDNELFTTNDIRQQIAYLNNELYAKKSTTIEDFMKQHGLLFENIELDKWDRLLAGWRINKRLKLGELSTGMLMKVKIGSVLARKAKLYLYDEPFASIDIMARSEVMKAIISETNPDAITIISSHHLEGTEKLYSKLWLIKDNTLQTIETETYREETGNALIDFYKEEMNK
Atome Classification :
(20 SA)
---.........10.--.----..-....20........30........40........50.......-----.60-...----.--..----------------.------..--70.---.----..----....--80.-...--.-------...90-----..---......100---.----........110-.-----------------.......--.---120---------.---.---------------...---------....130.......140.......150.......160.......170.-.--..--....-180........190.--......200..-------....-.--.210....-...220.......--------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MLVG
N
N
I
A
K
SYP--N----
K
L
-
V
L
Q
NVDFEAKSG
D
M
I
V
L
TGENGSG
K
T
T
L
L
D
M
L
A
S
LKKPDSG
T
L
-----
E
L--DNE----L--F
T
----------------
T
------
N
D
--
I
R
Q
---
Q
----
I
A
----
Y
L
NN--ELY-AKK--S-------T
T
I
E
D
-----
F
M
---
K
QHG
L
L
F
-----E----NIE
L
D
K
W
D
R
---
L
-----------------
L
AGWRIN--
K
---
R
-----------
L
---K---------------LGE---------LST
G
M
L
M
K
V
K
I
G
S
V
L
A
R
K
A
K
L
Y
L
YDEPFA
S
I
D
I
M
A
R
S
E
V
M
K
A
I
I
S-ET-N--P
D
--
A
I
T
I
-
I
S-SHHLE
G
T
E
K
L
Y
S
--
K
L
W
L
I
KD-N
T
L
-------
Q
T
IE-
T
--
E
T
Y
R
E
ETG-
N
A
L
I
D
F
Y
K
E
E
MNK--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.09
27%
-80
- C1 -
1VPL
2
?
A:
[16-232]
----
V
V
V
K
D
L
R
K
R
I
G
--
K
----
K
E
-
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
-----
T
V
FG
K
N
V
----
V
--
E
E
----------------
P
------
H
E
--
V
R
K
---
L
----
I
S
----
Y
L
P
E
--
E
A
G
-
A
Y
R
--
N
-------
M
Q
G
I
E
-----
Y
L
---
R
F
V
A
G
F
Y
ASS
S
S
E
----
I
E
E
M
V
E
R
A
T
---
E
-----------------
I
A
G
L
G
E
K
--
I
---
K
-----------
D
---
R
---------------
V
S
T
---------
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
-
I
L
K
-
Q
A
-
S
--
Q
E
--
G
L
T
I
L
V
S
-
S
H
N
M
L
E
V
E
F
L
C
D
--
R
I
A
L
I
H
N
-
G
T
I
---------
V
E
-
T
--
G
T
V
E
E
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.86
26%
-80
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-221]
----
L
T
A
K
N
L
A
K
A
Y
K
--
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
-----
I
I
--
D
D
D
DISL
L
--
P
L
----------------
H
------
A
R
--
A
R
R
---
G
----
I
G
----
Y
L
P
Q
--
E
A
S
-
I
F
R
--
R
-------
L
S
V
Y
D
N
L
M
A
V
L
Q
---
I
R
D
D
L
S
A
-----
E
----
Q
R
E
-
D
R
A
N
E
---
L
-----------------
M
E
E
F
H
I
E
--
H
L--
R
-----------
D
---
S
---------------
M
G
Q
S--------
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
-
D
--
S
G
--
L
G
V
L
-
I
T
-
D
H
N
V
R
E
T
L
A
V
C
E
--
R
A
Y
I
V
S
Q
-
G
H
L
-------
I
A
H
G
-
T
--
P
T
----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.33
26%
-76
- C1 -
4QC2
2
?
A:
[4-222]
----
L
T
A
K
N
L
A
K
A
Y
K
--
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
-----
I
I
--
D
D
D
DISL
L
--
P
L
----------------
H
------
A
R
--
A
R
R
---
G
----
I
G
----
Y
L
P
Q
--
E
A
S
-
I
F
R
--
R
-------
L
S
V
Y
D
N
L
M
A
V
L
Q
---
I
R
D
D
L
S
A
-----
E
----
Q
R
E
-
D
R
A
N
E
---
L
-----------------
M
E
E
F
H
I
E
--
H
L--
R
-----------
D
---
S
---------------
M
G
Q
S--------
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
-
D
--
S
G
--
L
G
V
L
-
I
T
-
D
H
N
V
R
E
T
L
A
V
C
E
--
R
A
Y
I
V
S
Q
-
G
H
L
-------
I
A
H
G
-
T
--
P
T
----------------------------------------------------------------------------------------------------------------------------
48
HHSearch
85.26
23%
-87
- C1 -
1VPL
2
?
A:
[16-251]
----
V
V
V
K
D
L
R
K
R
I
G
--
K
----
K
E
-
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
-----
T
V
--
F
G
K
----
N
--
V
V
----------------
E
E
P
----
H
E
--
V
R
K
---
L
----
I
S
----
Y
L
P
E
--
E
A
G
-
A
Y
R
--
N
-------
M
Q
G
I
E
-----
Y
L
---
R
F
V
A
G
F
Y
-----
A
SS
S
-
S
E
I
E
E
M
V
E
R
---
A
-----------------
T
E
I
A
G
L
G
EK
I
---
K
-----------
D
---
R
---------------
V
S
T
---------
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
-
A
S
-
Q
--
E
G
--
L
T
I
L
-
V
S
-
S
H
N
M
L
E
V
E
F
L
C
D
--
R
I
A
L
I
H
N
-
G
T
I
-------
V
E
T
G
T
V
--
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
---------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.55
25%
-73
- C1 -
4P33
7
LPTB_ECOLI
A:
[3-221]
----
L
T
A
K
N
L
A
K
A
Y
K
--
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
-----
I
I
--
D
D
D
DISL
L
--
P
L
----------------
H
------
A
R
--
A
R
R
---
G
----
I
G
----
Y
L
P
Q
--
E
A
S
-
I
F
R
--
R
-------
L
S
V
Y
D
N
L
M
A
V
L
Q
---
I
R
D
D
L
S
A
-----
E
----
Q
R
E
-
D
R
A
N
E
---
L
-----------------
M
E
E
F
H
I
E
--
H
L--
R
-----------
D
---
S
---------------
M
G
Q
S--------
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
-
D
--
S
G
--
L
G
V
L
-
I
T
-
D
H
N
V
R
E
T
L
A
V
C
E
--
R
A
Y
I
V
S
Q
-
G
H
L
-------
I
A
H
G
-
T
--
P
T
----------------------------------------------------------------------------------------------------------------------------
29
HHSearch
83.43
22%
-83
- C1 -
1Z47
1
?
A:
[14-238]
---
T
I
E
F
V
G
V
E
K
I
Y
P
G-
G
----
A
R
-
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
-----
W
I
--
G
G
K
----
R
--
V
T
----------------
D
L-----
P
P
--
Q
K
R
---
N
----
V
G
----
L
V
F
Q
--
N
Y
A
-
L
F
Q
--
H
-------
M
T
V
Y
D
-----
N
V
---
S
F
G
L
R
E
K
-----
R
VP
K
-
D
E
M
D
A
R
V
R
E
---
L
-----------------
L
R
F
M
R
L
E
SY
A
---
N
-----------
R
---
F
---------------
P
H
E
---------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
-
V
H
-
D
E
-
M
G
--
V
T
S
V
-
F
V
-
T
H
D
Q
E
E
A
L
E
V
A
D
--
R
V
L
V
L
H
E
-
G
N
V
-------
E
Q
F
G
T
P
--
E
E
V
Y
E
K
P
G
----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.03
26%
-75
- C1 -
2IHY
1
?
A:
[25-243]
-------
D
Q
I
G
R
M
K
Q
--
G
----
K
T
-
I
L
K
K
I
S
W
Q
I
A
K
G
D
K
W
I
L
Y
G
L
N
G
A
G
K
T
T
L
L
N
I
L
N
A
Y
E
P
A
T
S
G
T
V
-----
N
L
--
F
G
K
----
M
PG
Y
S
----------------
A
------
E
T
--
V
R
Q
---
H
----
I
G
----
F
V
S
H
--
S
L
L
-
E
K
F
--
Q
EGER
V
I
D
V
V
I
S
G
-----
A
----------------------
I
D
D
E
I
R
N
E
---
A
H
Q
L
L
K
------------
L
V
G
M
S
A
K
--
A
---
Q
-----------
Q
---
Y
---------------
I
G
Y
---------
L
S
T
G
E
K
Q
R
V
M
I
A
R
A
L
M
G
Q
P
Q
V
L
I
L
D
E
P
A
A
G
L
D
F
I
A
R
E
S
L
L
S
I
L
D
S
-
L
S
-
D
S
Y
P
T
--
L
A
M
I
-
Y
V
-
T
H
F
I
E
E
I
T
A
N
F
S
--
K
I
L
L
L
K
D
-
G
---------
Q
S
I
Q
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.77
25%
-84
- C1 -
4RVC
-
?
A:
[8-209]
--------
D
L
S
G
G
Y
T
--
A
----
Q
N
-
V
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
-----
S
I
--
N
G
Y
----
R
--
L
A
----------------
D
------
G
P
E
T
Y
R
R
---
Q
----
F
A
----
Y
I
P
E
--
T
P
V
-
L
Y
E
--
E
-------
L
T
L
E
E
-----
H
L
---
R
L
A
A
M
A
Y
-----
G
----
L
S
E
A
E
Y
E
R
R
L
P
P
L
-----------------
L
R
E
F
R
L
E
--
R
---
R
-----------
L
---
S
SF-------------
P
A
H
---------
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
R
M
N
E
-
Q
K
-
A
--
K
G
--
A
G
I
L
-
L
S
-
T
H
I
L
A
T
A
E
R
-
Y
C
--
D
S
F
V
I
L
H
-
N
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.57
25%
-88
- C1 -
4WBS
1
?
A:
[40-272]
----
L
V
V
R
N
L
K
K
R
Y
G
--
S
----
R
T
-
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
-----
D
L
--
D
G
K
----
S
--
I
S
----------------
L
------
L
P
--
I
H
K
---
R
A
S
L
G
L
S
----
Y
L
P
Q
--
E
A
S
-
V
F
R
--
K
-------
L
S
V
E
E
-----
N
I
---
R
A
---
V
L
-----
E
----
L
Q
V
G
D
D
G
K
R
---
L
S
K
D
A
I
A
S
R
T
E
A
L
L
D
E
L
Q
I
S
H
L
R
E
N
--
P
---
A
-----------
L
---------------------
S
---------
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
K
F
-
L
K
-
Q
--
R
N
--
I
G
V
L
-
I
T
-
D
H
N
V
R
E
T
L
G
I
C
D
--
H
A
Y
I
I
S
D
-
G
S
V
LAAGA
P
G
D
I
I
E
-
N
--
E
S
V
R
--------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.17
21%
-56
- C1 -
1Z47
1
?
A:
[19-250]
--------
G
V
E
K
I
Y
P
--
G
----
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
-----
W
I
--
G
G
K
----
R
--
V
T
----------------
D
------
L
P
--
P
Q
K
---
R
----
N
V
----
G
L
V
F
--
Q
N
Y
-
A
-----------------------
L
---
F
Q
H
M
T
V
Y
-----
D
----
N
V
S
F
G
L
R
E
K
---
R
-----------------
V
P
K
D
E
M
D
--
A
---
R
-----------
V
---
R
E
L
L
R
F
M
RLESYANRF
P
H
E
---------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
-
L
R
T
F
V
R
-
Q
V
-
H
--
D
E
M
G
V
T
S
V
-
F
V
-
T
H
D
Q
E
E
A
L
E
V
A
D
--
R
V
L
V
L
H
E
-
G
N
V
-------
E
Q
F
G
-
T
P
-
E
E
V
Y
E
K
P
G
-
T
L
F
V
A
S
F
I
G
E
S
N
---------------------------------------------------------------------------------------------------------
38
HHSearch
80.04
20%
-86
- C1 -
3TUI
1
METN_ECOLI
C:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
GTRT
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
-----
L
V
--
D
G
Q
----
E
--
L
T
----------------
T
LSESEL
T
K
--
A
R
R
---
Q
----
I
G
----
M
I
F
Q
--
H
F
N
-
L
L
S
--
S
-------
R
T
V
F
G
-----
N
V
---
A
L
P
L
E
L
D
-----
N
TPK-
D
E
V
K
R
R
V
T
E
---
L
-----------------
L
S
L
V
G
L
G
DK
H
---
D
-----------
S
---
Y
---------------
P
S
N
---------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
-
I
N
-
R
R-
L
G
--
L
T
I
L
-
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
--
C
V
A
V
I
S
N
-
G
E
L
-------
I
E
Q
D
T
V
--
S
E
V
F
S
H
------------------------------------------------------------------------------------------------------------------------
53
Fugue
79.83
23%
-60
- C1 -
1Z47
1
?
A:
[11-355]
GSM
T
I
E
F
V
G
V
E
K
I
Y
P
--
G
----
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
-----
W
I
--
G
G
K
----
R
--
V
T
----------------
D
------
L
P
--
P
Q
K
RN
V
G
----
L
V
----
F
Q
N
Y
--
A
L
F
-
Q
H
M
T
V
Y
-------
D
N
V
S
F
-----
G
L
---
R
E
K
R
V
P
K
-----
D
----
E
M
D
-
A
R
V
R
E
---
L
-----------------
L
R
F
M
R
L
E
--
S
---
Y
-----------
A
NR-
F
---------------
P
H
E
---------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
-
V
H
-
D
--
E
M
--
G
V
T
S
-
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
--
R
V
L
V
L
H
E
G
N
V
E
-------
Q
F
G
T
-
P
--
E
E
V
Y
E
K
P
G
-
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
32
HHSearch
78.70
22%
-87
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-236]
---
A
L
H
I
G
H
L
S
K
S
F
Q
--
N
----
T
P
-
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
-----
S
L
--
S
G
K
----
T
--
I
F
SKN
T
N
-----------
L
------
P
V
--
R
E
R
---
R
----
L
G
----
Y
L
V
Q
--
E
G
V
-
L
F
P
--
H
-------
L
T
V
Y
R
-----
N
I
---
A
Y
G
L
G
N
G
-----
K
GRT-
A
Q
E
R
Q
R
I
E
A
---
M
-----------------
L
E
L
T
G
I
S
EL
A
---
G
-----------
R
---
Y
---------------
P
H
E
---------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
-
A
L
R
A
--
N
G
--
K
S
A
V
-
F
V
-
S
H
D
R
E
E
A
L
Q
Y
A
D
--
R
I
A
V
M
K
Q
-
G
R
I
-------
L
Q
T
A
S
P
--
H
E
L
Y
R
Q
P
A
----------------------------------------------------------------------------------------------------------------------
44
HHSearch
78.57
22%
-86
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-236]
---
I
L
K
V
E
E
L
N
Y
N
Y
S
D-
G
----
T
H
-
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
-----
L
F
--
D
N
K
----
P
--
I
D
YS
R
K
G
-----------
I
------
M
K
--
L
R
E
---
S
----
I
G
----
I
V
F
Q
--
D
P
D
N
Q
L
F
--
S
-------
A
S
V
Y
Q
-----
D
V
---
S
F
G
A
V
N
M
-----
K
LP
E
-
D
E
I
R
K
R
V
D
N
---
A
-----------------
L
K
R
T
G
I
E
HL
K
---
D
-----------
K
---
P
---------------
T
H
C
---------
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
-
M
Q
-
K
E
-
L
G
--
I
T
I
I
-
I
A
-
T
H
D
I
D
I
V
P
L
Y
C
D
--
N
V
F
V
M
K
E
-
G
R
V
-------
I
L
Q
G
N
P
--
K
E
V
F
A
E
K
E
----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.83
31%
-88
- C1 -
2PJZ
5
?
A:
[7-205]
-----
V
G
I
T
L
S
G
K
G
Y
--
E
----
R
F
-
S
L
E
N
I
N
L
E
V
-
N
G
E
K
V
I
I
L
G
P
N
G
S
G
K
T
T
L
L
R
A
I
S
G
L
-
L
P
Y
S
G
N
I
-----
F
I
--
N
G
--------
M
E
----------------
V
------
R
K
--
I
R
N
---
Y
----
I
R
----
Y
S
T
N
LP
E
A
Y
--
E
I
--
G
-------
V
T
V
N
D
-----
I
V
-------
Y
L
Y
-----
E
------
E
L
K
G
L
D
R
---
D
-----------------
L
F
-
L
E
M
L
--
K
---
A
-----------
L
---
K
---------------
L
G
E
EILRRKLYK
L
S
A
G
Q
S
V
L
V
R
T
S
L
A
L
A
S
Q
P
E
I
V
G
L
D
E
P
F
E
N
V
D
-
A
A
R
R
H
V
I
S
R
Y
I
K
-
E
Y
-
G
--
K
E
--
G
I
L
V
----
T
H
E
L
D
-
M
L
N
L
Y
K
E
Y
K
A
Y
F
L
V
G
-
N
R
L
-------
Q
-------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.18
26%
-80
- C1 -
4MKI
4
ECFA2_CALS4
B:
[25-238]
-----------------------
V
-
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
NGI
D
I
--
T
D
K
----
K
--
V
S
----------------
L
------
K
D
--
I
R
K
---
Q
----
V
G
L
V
F
Q
Y
P
E
Y
--
Q
L
F
---
E
--
E
-------
T
V
F
K
D
-----
I
A
F
G
P
S
N
L
G
L
S
E
-----
E
----
E
V
K
E
R
V
Y
E
A
---
M
E
----------------
I
V
G
--
I
S
--
K
---
E
-----------
L
ADK
S
---------------
P
F
E
---------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
--
Y
K
--
M
I
T
I
-
L
V
-
S
H
N
M
E
D
I
A
R
I
A
D
--
K
I
I
V
M
N
R
-
G
K
I
-------
E
L
I
G
-
T
P
R
E
V
F
R
E
-------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.69
20%
-81
- C1 -
2YYZ
3
?
A:
[3-226]
---
S
I
R
V
V
N
L
K
K
Y
F
G
--
K
----
V
K
-
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
-----
Y
F
--
D
D
V
----
L
--
V
N
----------------
D
I-----
P
P
--
K
Y
R
---
E
----
V
G
----
M
V
F
Q
--
N
Y
A
-
L
Y
P
--
H
-------
M
T
V
F
E
-----
N
I
---
A
F
P
L
R
A
R
-----
R
ISK-
D
E
V
E
K
R
V
V
E
---
I
-----------------
A
R
K
L
L
I
D
NL
L
---
D
-----------
R
---
K
---------------
P
T
Q
---------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
-
L
Q
-
Q
E
-
L
G
--
I
T
S
V
-
Y
V
-
T
H
D
Q
A
E
A
M
T
M
A
S
--
R
I
A
V
F
N
Q
-
G
K
L
-------
V
Q
Y
G
T
P
--
D
E
V
Y
D
S
P
K
----------------------------------------------------------------------------------------------------------------------
46
HHSearch
74.57
20%
-89
* C1 *
2OLJ
4
?
A:
[24-251]
---
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-----
I
I
--
D
G
I
----
N
--
L
K
AKDTN-----------
L
------
N
K
--
V
R
E
---
E
----
V
G
----
M
V
F
Q
--
R
F
N
-
L
F
P
--
H
-------
M
T
V
L
N
-----
N
I
---
T
L
A
P
M
K
V
-----
R
KWP
R
E
K
A
E
A
K
A
M
E
---
L
-----------------
L
D
K
V
G
L
K
DK
A
---
H
-----------
A
---
Y
---------------
P
D
S
---------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
--
E
G
--
M
T
M
V
-
V
V
-
T
H
E
M
G
F
A
R
E
V
G
D
--
R
V
L
F
M
D
G
-
G
Y
I
-------
I
E
E
G
K
P
--
E
D
L
F
D
R
P
Q
----------------------------------------------------------------------------------------------------------------------
47
HHSearch
73.84
20%
-96
- C1 -
1B0U
4
HISP_SALTY
A:
[7-244]
----
L
H
V
I
D
L
H
K
R
Y
G
--
G
----
H
E
-
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
-----
I
V
--
N
G
Q
----
N
--
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
------
R
L
--
L
R
T
---
R
----
L
T
----
M
V
F
Q
--
H
F
N
-
L
W
S
--
H
-------
M
T
V
L
E
-----
N
V
---
M
E
A
P
I
Q
V
LGLS-
K
----
H
D
A
R
E
R
A
L
K
---
Y
-----------------
L
A
K
V
G
I
D
--
E
RAQ
G
-----------
K
---
Y
---------------
P
V
H
---------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
-
L
A
-
E
--
E
G
--
K
T
M
V
-
V
V
-
T
H
E
M
G
F
A
R
H
V
S
S
--
H
V
I
F
L
H
Q
-
G
K
I
-------
E
E
E
G
D
P
--
E
Q
V
F
G
N
P
-----------------------------------------------------------------------------------------------------------------------
45
HHSearch
73.34
17%
-94
- C1 -
3GD7
2
CFTR_HUMAN (first)
A:
[20-246]
----
M
T
V
K
D
L
T
A
K
Y
T
EG
G
----
N
A
-
I
L
E
N
I
S
F
S
I
S
P
G
Q
R
V
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
L
L
N
-
T
E
G
E
I
-----
Q
I
--
D
G
V
----
S
--
W
D
SIT-------------
L
------
E
Q
--
W
R
K
---
A
----
F
G
----
V
I
P
Q
--
K
V
F
-
I
F
S
----------
G
T
F
R
K
-----
N
L
---
D
P
N
A
A
H
-------------
S
D
Q
E
I
W
K
---
V
-----------------
A
D
E
V
G
L
R
S
V
I
---
E
Q
FPGKLD
F
V
L
V
D
---
G
---------------
G
C
V
---------
L
S
H
G
H
K
Q
L
M
C
L
A
R
S
V
L
S
K
A
K
I
L
L
L
D
E
P
S
A
H
L
D
P
V
T
Y
Q
I
I
R
R
T
L
K
Q
-
A
F
----
A
D
--
C
T
V
I
-
L
C
-
E
A
R
I
E
A
M
-
L
E
C
D
--
Q
F
L
V
I
E
E
-
N
K
V
-------
R
Q
Y
D
S
I
--
L
E
L
Y
H
Y
P
A
-
D
--------------------------------------------------------------------------------------------------------------------