@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0942: (2016-03-20 )
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASLTGDNNEKTLIIEDNGIGLTEDEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCFIVSDEIVMISTSQKDGGTTEWRGKADGTYSVRKIETDTREPGTQVYLRLRAGLEDHPECEDVEYLINTLKKYGASLESNIIVEMNGLEEEINSWTKQFSDKETLSTLSREQIIQYGEYILGTHFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNKMFVTSEANNILPDWSFFAKCVIWTDELQPVASREAFYKNERLTSVASELGVALKKGIETLPEEALMKLLATHYLGFKALASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYTYSVDDFRQIKDIARSSGMTLINGGYSYDSPILAQLSYFVEGTEFVLIQPEEMTDKLRPMTADEKQAYQPILTEMNSMMAEFDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETTSVFSDILESIQKEQEPAPLAHLYLNLDNELIKRLFTSEKTVKELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEML
Atome Classification :
(37 SA)
.........10........20........30........40---.-....--------..----.----50---..---......------.60........70........80........90........100----.---........110.......120......--.130--....--...-140.......150...-.-...160--........170.......180.......190.......200---....--.---------.-----.210--.........220.......230.--......--240.--........250---..-.------....260.......270---.....-----...280.........290.......300.......310.......320.......330.......340..---...-..-350......--------.360...-------....370....--...-------380----.-----.......390----.......400.......-----410---.........420.......430.......440.......-----450....--..----.460.......470....-...480----.........490.......500.......510.......520.......530.......540.......550......---.----560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENY
S
H
R
F
Q
V
N
L
A
G
M
I
D
I
L
S
N
HLYDE
K
D
V
Y
I
R
E
L
L
Q
N
A
T
D
A
---
I
-
R
A
R
K
--------
K
I----D----S----TL---E
G
K
I
H
A
------
S
L
TGDNN
E
K
T
L
I
I
EDNGIGL
T
E
D
E
V
H
A
F
L
A
T
I
ANSSKGEKNF------D---GESSN
D
F
I
G
R
F
G
I
G
L
L
S
C
F
IVSD
E
I
V
M
--
I
STS--QKDG--GTT-EWRGKADG
T
Y
S
V
R
K
IE-T-DTREP---G
T
Q
V
Y
L
R
L
RAGLEDHPE
C
E
D
V
E
Y
L
I
N
T
L
K
K
YGASLES
N
I
I
V
---
E
MN
G
--
L
---------
E
-----
E
E
----
I
N
S
W
T
K
QFS
D
K
E
T
L
S
T
L
S
R
E
Q
I
I
--
Q
Y
G
E
Y
I
--
L
--G--THF
Q
D
Y
F
L
I
EN---ES-G------
R
T
F
G
I
A
Y
MIPHAV
Q
M
N
----
A
IRKN-----
T
V
F
L
--
N
K
M
F
VTSEANNILP
D
W
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F
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A
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C
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TDELQ
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A
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Y
KN
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L
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K
G
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P
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---
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A
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-
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K
-
L
L
A
T
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Y
LG
F
--------
K
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LASED-------A
P
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IYPYL--
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R-------TL-----N-----G
E
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IA----KN
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NGGYSYD
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-----
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E
M
T
D
KL--RP----MTA
D
E
K
Q
A
Y
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N
S
-
M
M
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IKHFEPKD
L
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T
A
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EQEPAP
L
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L
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NL
D
N
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L
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FTS
E
K
---
T
----
V
K
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V
N
V
L
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LGHYPLK
R
K
E
M
V
LM
N
Q
N
M
L
R
I
L
E
ML-
1
PsiBlast_PDB
90.66
23%
-97
- C6 -
2IOQ
-
HTPG_ECOLI
A:
[15-623]
-------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
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--------
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---
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--
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---------
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DGET
V
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----
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SPHL
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L
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L
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L
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D
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VDESL
E
K
L
A
-------------
K
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A
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K
A
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K
A
-
L
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------
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--
S
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A
--------------------------------
K
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P
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V
L
V
K
R
A
A
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---
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----
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-
F
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W
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L
L
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G
T
L
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D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
113
HHSearch
83.09
21%
-89
- C4 -
2IOQ
-
HTPG_ECOLI
A:
[15-623]
-------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
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S
N
A
S
D
A
---
A
-
D
K
L
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--------
F
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AL--
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NPDL
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----
E
G
---
D
G
E
L
R
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------
R
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G
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G
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T
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A
K
--------------------
K
D
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F
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S
A
F
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A
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---
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DGET
V
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-----
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----
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K
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F
W
Q
Q
F
G
L
V
L
--------
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-------
F
A
N
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A
I
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--
R
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A
-------
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HTDSS
A
-----
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Y
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MKE
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Y
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A
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D
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A
A
A
-----
K
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SPHL
E
L
L
R
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K
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I
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V
L
L
L
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R
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D
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W
M
M
N
Y
L
T
E
-
F
D
G
K
P
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Q
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V
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K
-----
V
D
E
S
L
E
K
LA--------
K
E
A
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A
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A
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L
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------
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A
----------------------------------
K
Y
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L
V
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R
A
A
D
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--------
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W
V
E
L
L
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A
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L
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T
L
--
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D
P
N
L
F
I
R
R
M
N
Q
L
L
V
---
111
HHSearch
82.12
20%
-72
- C4 -
2CG9
1
HSP82_YEAST
A:
[2-674]
-
A
S
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
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Y
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F
L
R
E
L
I
S
N
A
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A
---
L
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--------
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K
----
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LSDP
K
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---
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------
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M
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K
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N
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A
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------
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ALS
A
G
A
D
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G
F
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V
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Y
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---
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KEEEVQE
I
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K
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A
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--------
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-----
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L
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A
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A
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K
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--------
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L
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-------
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A
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L
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K
L
L
--
R
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-------
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-----
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SVD--
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L
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N
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A
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-----
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KSPFL
D
A
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K
A
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N
F
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V
L
F
L
T
D
P
I
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E
Y
A
F
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L
K
E
-
F
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K
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L
V
D
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T
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-----
D
-
F
E
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E
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--
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K
A
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L
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A
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-
I
L
G
D
-------
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V
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K
V
V
V
S
Y
K
L
L
D
A
P
A
A
I
R
T
G
Q
F
-
G
W
S
A
N
M
E
R
I
M
K
A
-
Q
A
------------------
K
T
F
E
I
S
P
K
S
P
I
I
K
E
L
K
K
R
V
D
---
E
GGAQ
D
K
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
--
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
L
--
112
HHSearch
79.46
20%
-78
* C4 *
2O1U
3
?
A:
[34-657]
--------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
---
L
-
D
K
I
R
--------
L
I
S
L--
T
----
D
ENAL
A
G
---
N
E
E
L
T
V
------
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
--
T
S
K
H
--
N
N
D
---
T
Q
H
-
I
W
E
S
D
S
-
N
E
F
S
V
I
A
D
P
R
G
-
N
T
L
G
R
---
G
T
T
I
T
L
V
L
K
E
E
A
S
---
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
---
W
S
S
K
V
W
D
---------
W
-----
E
L
----
M
N
D
I
K
P
I
W
Q
R
P
S
K
--
E
V
E
D
D
E
Y
K
--
A
F
Y
K
S
F
--
S
--
K
ES
D
D
P
M
A
Y
I
H
F
T
A
---
E
G
E
V
------
T
F
K
S
I
L
F
V
P
T
S
A
P
R
---------
Y
I
-----
K
L
Y
V
--
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
---
E
K
Y
N
D
T
-
F
W
K
E
F
G
T
N
I
--------
K
L
G
V
I
E
D
-------
H
S
N
R
T
R
L
A
K
L
L
--
R
F
Q
-------
S
S
-----
H
HP
S
--
D
I
T
S
L
D
Q
Y
V
E
R
MKE
K
Q
D
K
I
Y
F
M
A
G
S
S
-
R
K
E
A
-----
E
S
SPFV
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
-
F
D
G
K
R
F
Q
N
V
A
K
-----
E
G
V
K
F
D
E
--
S
E
K
T
K
E
S
R
E
A
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
-------
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
-
G
W
S
G
N
M
E
R
I
M
K
A
-
Q
A
Y
Q
T
G
K
D
I
S
T
N
--
Y
Y
A
S
Q
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
---
E
DED-
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
--
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
--
2
PsiBlast_PDB
76.88
23%
-83
- C6 -
1Y4S
2
HTPG_ECOLI
A:
[9-483]
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
-
R
F
R
A
--------
L
S
----
N
----
P
----
D
L
YEG
D
G
E
L
R
V
------
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
--
G
T
K
S
F
LES-----------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
--
R
T
R
A
A
G
E
K
P
E
--
N
G
V
-
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
-
K
-
E
D
R
-----
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
-----
L
P
V
---
E
I
E
K
--
R
---------
E
-----
E
K
DG
E
T
V
I
S
W
E
K
-
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
--
A
--
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
-
K
------
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
----
M
W
N
R
D
H
K
H
G
L
K
L
Y
V
--
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
----
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
---
K
-
L
-
A
K
-
D
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
FAN
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
DS
S
A
Q
-------
T
V
-----
S
-----
L
E
D
Y
V
S
R
M
K
E
----
G
Q
E
K
I
Y
Y
I
-
T
A
D
S
Y
A
A
A
-----
K
SSPH
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
-
D
G
K
P
F
Q
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.05
23%
-84
- C6 -
1Y4U
-
HTPG_ECOLI
A:
[9-489]
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
-
R
F
R
A
--------
L
S
----
N
----
P
----
D
L
YEG
D
G
E
L
R
V
------
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
--
G
T
--------------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
--
R
T
R
A
A
G
E
K
P
E
--
N
G
V
-
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
-
K
-
E
D
R
-----
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
-----
L
P
V
---
E
I
E
K
--
R
---------
E
-----
E
K
DG
E
T
V
I
S
W
E
K
-
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
--
A
--
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
-
K
------
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
----
M
W
N
R
D
HK
H
G
L
K
L
Y
V
--
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
----
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
---
K
-
L
-
A
K
-
D
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
FAN
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
DS
S
A
Q
-------
T
V
-----
S
-----
L
E
D
Y
V
S
R
M
K
E
----
G
Q
E
K
I
Y
Y
I
-
T
A
D
S
Y
A
A
A
-----
K
SSPHL
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
-
D
G
K
P
F
Q
S
V
S
K
V
D
E
S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
73.01
18%
-73
- C4 -
2O1U
3
?
A:
[34-661]
--------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
---
L
-
D
K
I
R
--------
L
I
----
S
----
L
----
T
D
---
E
N
A
L
A
G
NE
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
V
---------------------------------
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
--
T
S
K
---
H
N
N
D
--
T
Q
H
-
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
-
G
-
N
T
L
G
R
---
G
T
T
I
T
L
V
L
K
---
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
---
W
S
S
K
--
V
---------
W
-----
D
W
----
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
--
A
F
Y
K
S
F
--
S
--
K
ES
D
D
P
M
A
Y
I
H
F
T
A
---
E
G
-
E
------
V
T
F
K
S
I
L
F
V
P
T
----
S
----
A
P
R
Y
I
-----
K
L
Y
V
--
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
---
E
K
Y
-
N
D
T
F
W
K
E
F
G
T
N
I
--------
K
L
G
V
I
E
D
-------
H
S
N
R
T
R
L
A
K
L
L
--
R
F
Q
S
SHHP
S
D
I
T
-----
S
-----
L
D
Q
Y
V
E
R
M
K
E
----
K
Q
D
K
I
Y
F
M
A
G
-
S
S
R
K
E
A
-----
E
S
SPFV
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
-
D
G
K
R
F
Q
N
V
A
K
-----
E
G
V
K
F
D
E
--
S
E
----
K
T
K
E
S
R
E
A
I
E
K
E
F
E
P
L
L
N
-
W
M
K
D
KALKDK
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
W
S
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
T
G
------
K
D
I
S
T
N
Y
Y
A
S
Q
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
DE
D
----
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
I
117
HHSearch
69.07
20%
-77
- C4 -
1Y4S
2
HTPG_ECOLI
A:
[3-483]
-
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
---
A
-
D
K
L
R
--------
F
R
A
L
--
S
NPDL
Y
----
E
G
---
D
G
E
L
R
V
------
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
------
S
-------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
--
R
T
R
A
--
A
G
E
K
PE
N
G
V
-
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
----
K
E
D
R
---
G
T
E
I
T
L
H
L
R
E
G
E
D
---
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
---
E
K
R
E
--
E
KDG
E
T
V
I
S
-
W
-----
E
K
----
I
N
K
A
Q
A
L
W
T
R
N
K
S
--
E
I
T
D
E
E
Y
K
--
E
F
Y
K
H
I
--
A
--
H
DF
N
D
P
L
T
W
S
H
N
R
V
---
E
G
-
K
Q
-----
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
WNRD
H
K
H
G
L
-----
K
L
Y
V
--
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
DD
A
E
K
Y
-
Q
T
-
F
W
Q
Q
F
G
L
V
L
--------
K
E
G
P
A
E
D
-------
F
A
N
Q
E
A
I
A
K
L
L
--
R
F
A
-------
S
T
-----
H
TDSSA
Q
T
V
S
L
E
D
Y
V
S
R
MKE
G
Q
E
K
I
Y
Y
I
T
A
-
D
S
Y
A
A
A
-----
K
SSPH
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
-
F
D
G
K
P
F
Q
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
57.95
25%
-59
- C6 -
4J0B
4
?
A:
[31-378]
-----
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
---
L
E
K
L
R
H
--------
R
M
I
TAG
G
----
D
----
T
A
---
P
M
E
I
H
--------
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
--
G
S
K
A
F
L
D
A
LQN
Q
---
A
E
A
S
S
S
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
--
Y
S
Q
S
A-
E
A
D
A
--
P
G
Y
-
K
W
S
S
D
G
S
G
V
F
E
V
--
A
E
-
A
-
S
G
V
R
Q
---
G
T
K
I
V
L
H
L
K
---
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
F
L
---
N
G
R
R
--
L
---------
N
-----
T
L
----
Q
A
L
W
M
M
E
P
K
D
------
I
S
E
W
Q
H
E
--
E
F
Y
R
Y
V
--
A
--
Q
--
A
Y
D
K
P
R
Y
T
L
H
Y
---
R
A
-
D
A
PLN
I
R
S
I
F
Y
V
P
E
M
K
P
------------
M
G
S
-----
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.74
24%
-67
- C6 -
4Z1I
2
TRAP1_HUMAN
A:
[29-344]
-----
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
---
L
E
K
L
R
H
--------
K
L
V
S
--
D
----
G
----
Q
A
---
L
P
E
M
E
I
------
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
--
G
S
K
A
F
L
D
A
L------
A
E
A
S
S
K
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
--
Y
S
R
S
--
A
A
P
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
--
A
E
-
A
-
S
G
V
R
T
---
G
T
K
I
I
I
H
L
K
S
---
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
NGR
R
M
N
T
--
L
---------
Q
AIWMM----------
Q
H
E
------------------
E
F
Y
R
Y
V
--
A
--
Q
--
A
H
D
K
P
R
Y
T
L
H
Y
---
K
T
-
D
AP
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
S
M
------------------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
56.47
32%
-63
- C6 -
3R4N
1
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
TDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
55.96
16%
-91
- C4 -
3HJC
2
?
A:
[19-420]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
L
W
T
R
D
P
K
--
D
V
T
K
E
E
Y
A
--
A
F
Y
K
A
I
--
S
ND
W
--
E
D
P
A
A
T
K
H
F
S
V
---
E
G
-
Q
L
-----
E
F
R
S
I
M
F
V
P
K
R
A
P
F
P
N
K---
K
R
N
N
I
-----
K
L
Y
V
--
R
R
V
F
I
M
D
N
C
E
D
L
C
P
D
W
L
G
F
V
K
G
V
V
D
S
E
D
L
P
-----
E
N
L
Q
Q
N
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
M
F
D
E
V
A
E
N
K
-
E
D
Y
-
K
Q
-
F
Y
E
Q
F
G
K
N
I
--------
K
L
G
I
H
E
D
-------
T
A
N
R
K
K
L
M
E
L
L
--
R
F
Y
-------
S
T
-----
E
SGE--
E
M
T
T
L
K
D
Y
V
T
R
MKA
G
Q
K
S
I
Y
Y
I
T
G
D
S
K
-
K
K
L
E
T
SPF
I
-----
E
Q
A
R
R
R
G
L
E
V
L
F
M
T
E
P
I
D
E
Y
V
M
Q
Q
V
K
D
-
F
E
D
K
K
F
A
C
L
T
K
-----
E
G
V
H
F
E
E
--
S
E
E
E
K
Q
Q
R
E
E
E
K
A
A
C
E
K
L
C
K
T
M
K
E
-
V
L
G
D
-------
K
V
E
K
V
I
V
S
E
R
L
S
T
S
P
C
I
L
V
T
S
E
F
-
G
W
S
A
H
M
E
Q
I
M
R
N
-
Q
--------
Q
Y
-----
M
M
S
K
K
T
M
E
L
N
P
R
H
P
I
I
K
E
L
R
R
R
V
G
---
A
DN--
D
K
A
V
K
D
L
V
F
L
L
F
D
T
S
L
L
T
S
G
F
Q
L
--
E
D
P
T
G
Y
A
E
R
I
N
R
M
I
K
L
--
24
PsiBlast_CBE
55.96
32%
-62
- C6 -
3RLQ
1
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
TDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
55.68
32%
-60
- C6 -
3EKO
2
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
---
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.61
32%
-54
- C6 -
2QG0
1
HS90A_HUMAN
A:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
TDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
55.48
32%
-61
- C6 -
3R4P
1
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
55.36
32%
-61
- C6 -
3VHD
2
HS90A_HUMAN
A:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
LTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
55.32
32%
-59
- C6 -
3K98
1
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
DPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
54.98
32%
-57
- C6 -
3TUH
1
HS90A_HUMAN
A:
[7-195]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
54.83
32%
-54
- C6 -
3WHA
2
HS90A_HUMAN
A:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
54.76
32%
-54
- C6 -
2QG0
1
HS90A_HUMAN
B:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
YESLTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
MEAL--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MGR
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.66
32%
-54
- C6 -
3TUH
1
HS90A_HUMAN
B:
[7-195]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
TDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
54.07
32%
-56
- C6 -
2WI6
1
HS90A_HUMAN
A:
[22-210]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
DPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
53.99
32%
-52
- C6 -
3B24
1
HS90A_HUMAN
B:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
YESLTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
MEAL--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MGR
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
53.93
32%
-54
- C6 -
2QFO
2
HS90A_HUMAN
A:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
53.84
32%
-51
- C6 -
3HHU
1
HS90A_HUMAN
B:
[22-210]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
YESLTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
MEAL--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MGR
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
53.77
32%
-52
- C6 -
3B26
1
HS90A_HUMAN
A:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
53.33
32%
-52
- C6 -
4W7T
1
HS90A_HUMAN
A:
[22-210]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.92
32%
-55
- C6 -
3B28
3
HS90A_HUMAN
A:
[15-203]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.19
32%
-51
- C6 -
3HHU
1
HS90A_HUMAN
A:
[22-210]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
LTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
52.08
32%
-51
- C6 -
2QF6
1
HS90A_HUMAN
D:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
YETLTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
MEAL--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MGR
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
51.59
32%
-51
- C6 -
2QF6
1
HS90A_HUMAN
C:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
YETLTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
MEAL--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MGR
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
51.15
32%
-51
- C6 -
2QF6
1
HS90A_HUMAN
A:
[6-194]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
T
L
T
DPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
50.89
32%
-53
- C6 -
2JJC
2
HS90A_HUMAN
A:
[17-205]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
LTDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
50.75
32%
-51
- C6 -
4FCP
1
HS90A_HUMAN
A:
[22-210]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
TDPS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.06
32%
-47
- C6 -
2XDU
4
HS90A_HUMAN
A:
[34-222]
-------
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
---
L
-
D
K
I
R
Y
E
S
L
T
D
PS
K
L
----
D
----
S
----
G
K
---
E
--
L
H
I
------
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
--
G
T
K
A
F
M
E
A
L
--
Q
---
A
G
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
--
I
-
T
K
--
H
N
D
D
--
E
Q
Y
-
A
W
E
S
S
A
G
G
S
F
T
V
R
----
T
-
D
T
G
E
P
MG
R
G
T
K
V
I
L
H
L
K
---
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.71
33%
-55
- C6 -
2IOR
4
HTPG_ECOLI
A:
[29-203]
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
-
R
F
R
A
--------
L
S
----
N
----
P
----
D
L
YEG
D
G
E
L
R
V
------
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
--
G
T
K
S
F
L
E
S
LGS
D
---
Q
A
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
--
E
K
P
E
--
N
G
V
-
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
-
K
-
E
D
R
-----
G
T
E
I
T
L
H
L
R
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------