@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1726: (2016-03-28 )
MKLGIMGTNWITDSFIEGAINSGEWNLTAVYSRTEEKARAFGEKYGELTYFTDIEEMGKSDALDAVYIASPNALHYQHAVSLLKNKKHVIVEKPIFSTVAELEHAHQIARENNVFLFEAARHIQEPNFKRLQENIEKVGTIHGATLAYMKYSSRYDQVLNGEEPNIFSLKFSGGSIVDLGVYPLYSAITLFGEPVKATYFATKLPTGVDGLGPIILEYPTFNITIIQGKNSQSFLPSEIYGQKGTLIVDPLTGIEKITFYDNATKEETELAGPVVANDMQFEAAEFARIIEQSDRDTYEYLADLSLKVLRVSNELRHQNDIWFDAEK
Atome Classification :
(20 SA)
-.........10..-.-.--...--.20-..--......30........40........50........60........70........80........90........100.......110-.......120.......130.-----...--...140.......150.......160.....-..-170.......180.......190--.--.-.....200..------.------..-..210.......-----220-.-.....-...230--......--.240.....-..-250-.---...-----.-----..260-..------.-.--...-----------.-----.-270..----.......280.......290.......-300.......310.......320.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MKLG
I
M
GTNWI
T
D
-
S
-
F
--
I
EG--AIN-SG--E
W
N
L
T
A
V
YS
R
T
E
E
K
A
R
A
F
G
E
K
YGE
L
T
Y
F
T
D
I
E
E
MGKSDAL
D
A
V
Y
IASPN
A
L
H
Y
Q
H
A
V
S
L
LKNK
K
H
V
I
VEK
P
I
F
S
T
V
A
E
L
E
H
A
H
Q
I
A
REN-
N
V
F
L
F
E
A
A
R
HIQEP
N
F
K
R
L
Q
E
-----
N
I
E
--
K
VGTIH
G
A
T
L
A
Y
M
K
Y
S
S
R
Y
D
Q
VLNGEEP
N
I
F
-
S
L
-
K
FSG
G
S
I
V
D
L
G
V
Y
P
L
Y
S
A
I
T
LFG--E--P-V
K
A
T
Y
F
ATKL------P------TG-VDGL
G
P
I
I
L
EYP-----
T
---
F
-
N
I
T
I
I
-QGKNSQ--SFL
P
S
E
--IYGQKG
T
L
I
-VD-PLT-G---
I
E
K
-----
I
-----
T
FY---DN------A-T--K
E
E
-----------
T
-----E-L--AG----PVVANDMQ
F
E
A
A
E
F
A
R
I
I
E
QSDR
D
T
Y
E
-
Y
L
A
D
L
S
L
K
V
LR
V
S
N
E
LRHQND
I
W
FDAEK
21
PsiBlast_CBE
95.40
40%
-88
- C2 -
4NHE
13
?
C:
[5-328]
-
L
K
L
G
V
I
G
T
G
A
I
S
H
-
H
-
F
--
I
E
A
--
A
H
T
-
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
Q
N
I
Q
L
F
D
Q
L
E
V
F
F
K
S
-
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
C
F
I
F
E
A
A
R
N
Y
H
E
K
A
F
T
T
I
K
------
N
F
L
--
A
D
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
G
Q
T
P
N
V
F
-
S
D
-
R
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
-
N
D
A
T
Y
H
A
Q
Q
L
------
D
------
N
S
-
I
D
L
N
G
D
G
I
L
F
Y
P
-----
D
---
Y
-
Q
V
H
I
K
-
A
G
K
N
I
T
--
S
N
L
P
C
E
--
I
Y
T
T
D
G
T
L
T
-
L
N
-
T
I
E
-
H
---
I
R
S
-----
A
-----
I
F
T
---
D
H
--------
Q
--
G
N
Q
-----------
V
-----
Q
-
L
--
P
I
----
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
-
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
K
1
PsiBlast_PDB
95.30
40%
-91
* C2 *
4NHE
5
?
A:
[5-328]
-
L
K
L
G
V
I
G
T
G
A
I
S
H
-
H
-
F
--
I
E
A
--
A
H
T
-
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
Q
N
I
Q
L
F
D
Q
L
E
V
F
F
K
S
-
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
C
F
I
F
E
A
A
R
N
Y
H
E
K
A
F
T
T
I
K
------
N
F
L
--
A
D
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
G
Q
T
P
N
V
F
-
S
D
-
R
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
-
N
D
A
T
Y
H
A
Q
Q
L
------
D
------
N
S
-
I
D
L
N
G
D
G
I
L
F
Y
P
-----
D
---
Y
-
Q
V
H
I
K
-
A
G
K
N
I
T
--
S
N
L
P
C
E
--
I
Y
T
T
D
G
T
L
T
-
L
N
-
T
I
E
-
H
---
I
R
S
-----
A
-----
I
F
T
---
D
H
--------
Q
--
G
N
Q
-----------
V
-----
Q
-
L
--
P
I
----
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
-
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
K
22
PsiBlast_CBE
93.75
40%
-89
- C2 -
4NHE
9
?
B:
[5-328]
-
L
K
L
G
V
I
G
T
G
A
I
S
H
-
H
-
F
--
I
E
A
--
A
H
T
-
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
Q
N
I
Q
L
F
D
Q
L
E
V
F
F
K
S
-
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
C
F
I
F
E
A
A
R
N
Y
H
E
K
A
F
T
T
I
K
------
N
F
L
--
A
D
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
G
Q
T
P
N
V
F
-
S
D
-
R
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
-
N
D
A
T
Y
H
A
Q
Q
L
------
D
------
N
S
-
I
D
L
N
G
D
G
I
L
F
Y
P
-----
D
---
Y
-
Q
V
H
I
K
-
A
G
K
N
I
T
--
S
N
L
P
C
E
--
I
Y
T
T
D
G
T
L
T
-
L
N
-
T
I
E
-
H
---
I
R
S
-----
A
-----
I
F
T
---
D
H
--------
Q
--
G
N
Q
-----------
V
-----
Q
-
L
--
P
I
----
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
-
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
K
2
PsiBlast_PDB
81.94
40%
-66
- C2 -
2HO5
-
?
A:
[2-323]
-
L
K
L
G
V
I
G
T
G
A
I
S
H
-
H
-
F
--
I
E
A
--
A
H
T
-
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
Q
N
I
Q
L
F
D
Q
L
E
V
F
F
K
S
-
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
C
F
I
F
E
A
A
R
N
Y
H
E
K
A
F
T
T
I
K
------
N
F
L
--
A
D
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
--------------------
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
-
N
D
A
T
Y
H
A
Q
Q
L
------
D
------
N
S
-
I
D
L
N
G
D
G
I
L
F
Y
P
-----
D
---
Y
-
Q
V
H
I
K
-
A
G
K
N
I
T
--
S
N
L
P
C
E
--
I
Y
T
T
D
G
T
L
T
-
L
N
-
T
I
E
-
H
---
I
R
S
-----
A
-----
I
F
T
---
D
H
--------
Q
--
G
N
Q
-----------
V
-----
Q
-
L
--
P
I
----
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
-
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
--
3
PsiBlast_PDB
72.83
26%
-71
- C2 -
3EVN
-
?
A:
[6-315]
-
V
R
Y
G
V
V
S
T
A
K
V
A
P
-
R
-
F
--
I
E
G
--
V
R
L
-
A
G
--
N
G
E
V
V
A
V
S
S
R
T
L
E
S
A
Q
A
---
K
Y
H
L
P
K
A
Y
D
K
L
E
D
M
L
A
D
E
S
I
D
V
I
Y
V
A
T
I
N
Q
D
H
Y
K
V
A
K
A
A
L
L
A
G
K
H
V
L
V
E
K
P
F
T
L
T
Y
D
Q
A
N
E
L
F
A
L
A
E
S
C
-
N
L
F
L
M
E
A
Q
K
S
V
F
I
P
M
T
Q
V
I
K
K
L
L
A
S
G
E
I
G
--
E
V
I
S
I
-
S
S
T
T
A
Y
----
P
N
I
D
H
V
T
W
F
R
E
------
L
-
E
L
G
G
G
T
V
H
F
M
A
P
Y
A
L
S
Y
L
Q
Y
L
F
D
--
A
--
T
-
I
T
H
A
S
G
T
A
T
F
------
P
------
K
G
Q
S
D
S
Q
S
K
L
L
L
Q
L
S
-----
N
-----
G
V
L
V
D
-
I
F
L
T
T
R
--
L
N
L
P
H
E
M
I
I
Y
G
T
E
G
R
L
I
-
I
P
-
H
F
W
-
K
---
T
T
H
-----
A
-----
K
L
V
---
R
N
------
D
-
T
--
S
A
R
-----------
T
-----
I
-
Q
--
V
D
----
M
V
--
S
D
F
E
K
E
A
Y
H
V
S
Q
M
I
L
E
G
Q
R
V
S
H
I
-
M
T
P
Q
L
T
L
S
G
V
K
I
I
E
D
L
------------
71
HHSearch
70.48
24%
-76
- C2 -
3EVN
-
?
A:
[6-323]
-
V
R
Y
G
V
V
S
T
A
K
V
A
P
-
R
-
F
--
I
E
G
--
V
R
L
-
A
G
--
N
G
E
V
V
A
V
S
S
R
T
L
E
S
A
Q
A
---
K
Y
H
L
P
K
A
Y
D
K
L
E
D
M
L
A
D
E
S
I
D
V
I
Y
V
A
T
I
N
Q
D
H
Y
K
V
A
K
A
A
L
L
A
G
K
H
V
L
V
E
K
P
F
T
L
T
Y
D
Q
A
N
E
L
F
A
L
A
E
S
C
-
N
L
F
L
M
E
A
Q
K
S
V
F
I
P
M
T
Q
V
I
K
K
-----
L
L
A
S
G
E
I
G
E
V
I
S
I
S
S
T
T
A
Y
P
N
I
--------
D
H
V
T
W
F
R
E
L
-
E
L
G
G
G
T
V
H
F
M
A
P
Y
A
L
S
Y
L
Q
Y
L
F
D
--
A
--
T
I
T
H
A
S
G
T
A
T
F
P
------
K
------
G
Q
-
S
D
S
Q
S
K
L
L
L
Q
L
S
-----
N
---
G
V
L
V
D
I
F
-
L
T
T
R
L
N
--
L
P
H
E
M
I
--
I
Y
G
T
E
G
R
L
I
-
I
P
-
H
F
W
-
K
---
T
T
H
-----
A
-----
K
L
V
---
R
N
------
D
-
T
--
S
A
------------
R
-----
T
----
I
Q
----
V
D
M
V
S
D
F
E
K
E
A
Y
H
V
S
Q
M
I
L
E
G
Q
R
V
S
H
I
-
M
T
P
Q
L
T
L
S
G
V
K
I
I
E
D
L
Y
R
S
W
G
K
E
G
----
68
HHSearch
70.31
20%
-69
- C2 -
3OHS
10
DHDH_MACFA
X:
[3-332]
-
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
--
T
A
V
--
L
Q
T
-
L
P
RS
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
QG
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
--------
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
--
G
QK
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
-----
G
---
E
V
H
G
S
F
T
-
C
S
I
T
A
Q
--
L
S
N
T
A
S
--
V
S
G
T
K
G
M
A
Q
-
L
L
-
N
P
C
W
C
---
P
T
E
-----
L
-----
V
V
K
---
G
E
------
H
-
K
--
E
F
L
LPPV-------
P
-----
K
-
N
--
C
N
----
F
D
N
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
G
L
K
E
S
P
V
-
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-
59
Fugue
69.01
20%
-68
- C2 -
2O4U
9
DHDH_MACFA
X:
[2-332]
A
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
--
T
A
V
LQ
T
L
P
-
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
--
Q
-
G
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
-----
V
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
-----
G
E--
V
-
H
G
S
F
T
-
C
S
I
T
A
Q
--
L
S
N
T
A
S
--
V
S
G
T
K
G
M
A
Q
-
L
L
N
P
C
W
-
C
---
P
T
E
-----
L
-----
V
V
K
---
G
E
------
H
-
K
--
E
F
L
-----------
L
-----
P
-
P
--
V
P
KNCN
F
D
N
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
G
L
K
E
S
P
V
-
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-
74
HHSearch
67.16
19%
-77
- C2 -
3RC1
7
?
A:
[28-348]
-
I
R
V
G
V
I
G
C
A
D
I
A
W
-
R
R
A
--
L
P
A
--
L
E
A
-
E
P
--
L
T
E
V
T
A
I
A
S
R
R
W
D
R
A
K
R
F
T
E
R
F
G
G
-
E
P
V
E
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
V
L
H
A
E
W
I
D
R
A
L
R
A
G
K
H
V
L
A
E
K
P
L
T
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
-
G
L
L
L
M
E
N
F
M
F
L
H
H
P
Q
H
R
Q
V
A
D
-----
M
L
D
E
G
V
I
G
E
I
R
S
F
A
A
S
F
T
I
P
P
K
P
--------
Q
G
D
I
R
Y
Q
A
-
D
V
G
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
A
G
L
F
L
G
--
A
D-
L
-
E
F
V
G
A
V
L
R
H
E
R-----
D
------
R
D
-
V
V
V
G
G
N
A
L
L
T
T
R
-----
Q
---
G
V
T
A
Q
L
T
-
F
G
M
E
H
A
--
Y
T
N
N
Y
E
--
F
R
G
S
T
G
R
L
W
-
M
N
-
R
V
F
-
T
---
P
P
A
T
Y
Q
P
V
V
-----
H
I
E
----
R
------
Q
-
D
--
H
A
------------
E
-------
Q
--
F
V
----
L
P
A
H
D
Q
F
A
K
S
I
R
A
F
A
Q
A
V
L
S
G
E
H
--
P
R
-
E
W
S
E
D
S
L
R
Q
A
S
L
V
D
A
V
R
T
G
A
R
D
I
Y
----
69
HHSearch
66.92
21%
-70
- C2 -
1ZH8
7
?
A:
[19-337]
-
I
R
L
G
I
V
G
C
G
I
A
A
R
-
E
L
H
--
L
P
A
--
L
K
N
-
L
S
H-
L
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
M
V
G
N
P
A
V
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
-----
L
V
E
S
G
A
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
E
N
N
---
K
Y
V
H
T
D
W
R
K
K
P
-
K
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
--
E
--
I
-
E
W
I
S
A
V
A
K
D
L
SP----
L
------
L
G
-
G
M
D
F
L
S
S
I
F
E
F
E
-----
N
---
G
T
V
G
N
Y
T
-
I
S
Y
S
L
K
--
G
N
E
R
F
E
--
I
T
G
T
K
G
K
I
S
-
I
S
-
W
D
K
-------------
I
-----
V
L
N
---
E
---------
E
--
E
------------------------
M
K
----
V
P
Q
E
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
K
P
N
-
D
L
-
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
-
8
PsiBlast_PDB
66.48
24%
-82
- C2 -
3OHS
9
DHDH_MACFA
X:
[3-245]
-
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
TA
V
L
Q
--
T
L
P
-
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
--
Q
-
G
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
-----
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
GEVHG
S
---
F
-
T
C
S
I
T
A
Q
L
S
N
T
A
--
S
-------
V
S
G
T
K
G
---------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.07
24%
-84
- C2 -
2O4U
9
DHDH_MACFA
X:
[3-245]
-
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
TA
V
L
Q
--
T
L
P
-
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
--
Q
-
G
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
-----
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
GEVHG
S
---
F
-
T
C
S
I
T
A
Q
L
S
N
T
A
--
S
-------
V
S
G
T
K
G
---------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.70
24%
-80
- C2 -
2POQ
6
DHDH_MACFA
X:
[3-245]
-
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
TA
V
L
Q
--
T
L
P
-
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
--
Q
-
G
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
-----
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
GEVHG
S
---
F
-
T
C
S
I
T
A
Q
L
S
N
T
A
--
S
-------
V
S
G
T
K
G
---------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.00
24%
-82
- C2 -
2O48
6
DHDH_MACFA
X:
[3-245]
-
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
TA
V
L
Q
--
T
L
P
-
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
-----
V
L
A
--
Q
-
G
T
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
-----
P
R
A
V
-
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
-
E
K
I
S
V
M
G
R
R
H
------
E
------
T
G
-
V
D
D
T
V
T
V
L
L
Q
Y
P
GEVHG
S
---
F
-
T
C
S
I
T
A
Q
L
S
N
T
A
--
S
-------
V
S
G
T
K
G
---------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
64.83
19%
-72
- C2 -
3EZY
2
?
A:
[3-328]
-
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
-
H
--
A
E
N
--
L
K
M
-
I
D
--
D
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
E
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
V
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
-----
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
P
--------
P
L
D
Y
---
I
-
R
V
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
--
E
E-
V
-
E
E
V
F
A
D
G
S
V
L
VD
E
E
I
G
K
------
A
G
-
D
V
D
T
A
V
V
V
L
R
F
K
-----
S
---
G
A
L
G
V
I
D
-
N
S
R
R
A
V
Y
G
Y
D
Q
R
I
E
--
V
F
G
S
K
G
R
I
F
-
A
D
-
N
V
R
-----
E
T
T
-----
V
-----
V
L
T
---
D
E
------
Q
-
G
--
D
R
G
-----------
S
-----
R
Y
L
YF
F
L
----
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
P
--
P
A
-
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
---
86
HHSearch
64.41
18%
-80
- C2 -
3FHL
3
?
A:
[6-351]
-
I
K
T
G
L
A
A
F
G
M
S
G
Q
V
F
-
H
--
A
P
F
--
I
S
T
-
N
P
--
H
F
E
L
Y
K
I
V
E
R
S
K
E
L
S
K
E
---
R
Y
P
Q
A
S
I
V
R
S
F
K
E
L
T
E
D
P
E
I
D
L
I
V
V
N
T
P
D
N
T
H
Y
E
Y
A
G
M
A
L
E
A
G
K
N
V
V
V
E
K
P
F
T
S
T
T
K
Q
G
E
E
L
I
A
L
A
K
K
K
-
G
L
M
L
S
V
Y
Q
N
R
R
W
D
A
D
F
L
T
V
R
D
-----
I
L
A
K
S
L
L
G
R
L
V
E
Y
E
S
T
F
A
R
Y
R
N
F
---------------------
G
L
T
Y
N
L
G
S
H
L
I
D
Q
A
I
Q
L
F
G
--
M
--
P
-
E
A
V
F
A
D
L
G
I
L
------
R
EG----
G
K
-
V
D
D
Y
F
I
I
H
L
L
H
P
-----
S
LAP
N
V
K
I
T
L
K
-
A
S
Y
L
M
R
E-
A
E
P
R
F
A
--
L
H
G
T
L
G
S
Y
V
-
K
Y
-
G
V
-----------------------PNW
G
E
------
E
S
E
--
Q
E
W
G
L
L
H
T
E
I
NG
K
E
I
-----
C
-
R
--
K
Y
----
P
G
I
A
G
N
Y
G
G
F
Y
Q
N
I
Y
E
H
L
C
L
G
Q
P
--
L
E
-
T
H
A
Q
D
I
L
N
V
I
R
I
I
E
A
A
Y
Q
S
H
R
E
N
K
I
V
--
87
HHSearch
64.26
18%
-81
- C2 -
3M2T
3
?
A:
[6-335]
-
I
K
V
G
L
V
G
I
G
A
Q
M
Q
E
N
-
L
--
L
P
S
--
L
L
Q
-
M
Q
--
D
I
R
I
V
A
A
C
D
S
D
L
E
R
A
R
R
V
H
R
F
I
S
D
I
P
V
L
D
N
V
P
A
M
L
N
Q
V
P
L
D
A
V
V
M
A
G
P
P
Q
L
H
F
E
M
G
L
L
A
M
S
K
G
V
N
V
F
V
E
K
P
P
C
A
T
L
E
E
L
E
T
L
I
D
A
A
R
R
S
-
D
V
V
S
G
V
G
M
N
F
K
F
A
R
P
V
R
Q
L
R
E
-----
M
T
Q
VD
E
F
G
E
T
L
H
I
Q
L
N
H
Y
A
N
K
P
R
--------
A
P
L
W
G
L
D
S
--
T
L
R
S
F
L
L
A
Q
A
I
H
T
I
D
L
A
I
T
F
G
D
--
G
E-
L
-
R
R
V
Q
S
S
V
Q
R
--------------
H
D
-
D
A
L
I
V
R
A
D
M
A
F
S
-----
S
---
G
A
T
A
S
L
L
-
A
G
T
S
F
P
Y
-
F
E
F
D
M
K
--
L
V
S
S
S
S
T
L
V
E
L
D
-
N
L
W
-
N
-----------
I
-----
T
L
H
---
E
P
EHATRP
T
-
G
AA
K
R
W
R
G
A
W
-------
Q
P
G
---
P
-
L
--
D
S
----
G
Y
E
R
S
G
Y
H
G
E
L
H
Q
F
F
Q
A
I
R
E
H
R
R
--
F
E
-
A
D
F
A
S
L
L
P
T
Y
R
V
I
E
E
I
C
S
A
D
A
V
A
Q
G
---
78
HHSearch
63.78
15%
-70
- C2 -
3EUW
1
?
A:
[5-331]
-
L
R
I
A
L
F
G
A
G
R
I
G
H
-
V
-
H
--
A
A
N
--
I
A
A
-
N
P
--
D
L
E
L
V
V
I
A
D
P
F
I
E
G
A
Q
R
L
A
E
A
N
G
A
-
E
A
V
A
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
G
D
G
-
A
S
K
V
M
L
G
F
N
R
R
F
D
P
S
F
A
A
I
N
A
-----
R
V
A
N
Q
E
I
G
N
L
E
Q
L
V
I
I
S
R
D
P
A
P
A
--------
P
K
D
Y
I
----
A
G
S
G
G
I
F
R
D
M
T
I
H
D
L
D
M
A
R
F
F
V
P
--
N
--
I
-
V
E
V
T
A
T
G
A
N
V
------
F
S
Q
E
I
A
E
F
N
-
D
Y
D
Q
V
I
V
T
L
R
G
S
-----
K
---
G
E
L
I
N
I
V
-
N
S
R
H
C
S
Y
G
Y
D
Q
R
L
E
--
A
F
G
S
K
G
M
L
A
-
A
D
-
N
I
R
-----
P
T
T
-----
V
-----
R
K
H
---
N
A
------
E
-
S
--
T
E
Q
A
D
PI-------
F
-----
N
-
F
--
F
L
----
E
R
Y
D
A
A
Y
K
A
E
L
A
T
F
A
Q
G
I
R
D
G
Q
G
--
F
S
-
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
S
A
Q
T
G
R
T
V
T
-
70
HHSearch
63.30
16%
-71
- C2 -
3CEA
1
?
A:
[9-342]
-
L
R
A
A
I
I
G
L
G
R
L
G
E
-
R
-
H
--
A
R
H
--
L
V
N
K
I
Q
--
G
V
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
N
E
L
G
V
E
T
T
Y
T
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
Q
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
-----
I
V
D
N
G
D
I
G
K
I
I
Y
M
R
G
Y
G
I
D
P
I
S
G
M
E
-----
S
F
T
K
F
A
-
T
E
-
A
D
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
--
Q
D-
P
-
V
Q
A
Y
G
L
T
S
N
I
AA
P
Q
L
A
D
------
I
G
-
E
F
E
T
G
V
A
Q
L
K
M
S
-----
D
---
G
V
I
A
T
L
I
-
G
G
R
H
A
A
H
G
N
Q
V
E
L
E
--
V
M
G
S
N
G
W
V
R
-
I
G
-
E
H
P
-
D
---
L
N
R
-----
V
-----
T
V
F
---
N
D
------
Q
-
G
--
V
V
R
-----------
P
-----
S
-
L
QS
F
G
----
E
R
F
D
T
A
F
T
D
E
V
Q
D
F
V
N
N
V
I
V
G
K
Q
--
P
E
-
V
T
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
L
V
--
82
HHSearch
62.48
18%
-65
- C2 -
3DB2
-
?
A:
[6-347]
-
V
G
V
A
A
I
G
L
G
R
W
A
Y
-
V
-
M
--
A
D
A
--
Y
T
K
-
S
E
--
K
L
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
G
K
R
Y
N
C
-
A
G
D
A
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
-
G
V
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
-----
M
I
D
T
K
E
I
G
E
V
S
S
I
E
A
V
F
S
N
E
R
G
L
E
-----
L
K
K
G
N
W
R
G
E
P
A
T
A
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
L
Q
F
L
L
G
--
P
--
V
-
A
R
V
F
N
F
G
K
P
M
YT----
E
------
V
E
-
N
I
T
V
N
Q
T
L
L
E
F
E
-----
D
---
G
K
Q
A
Y
L
G
-
T
N
W
A
C
P
--
G
V
F
S
I
N
--
V
Y
G
T
K
A
N
L
F
-
Y
Q
-
L
D
F
-
S
WWS
N
S
D
-----
V
TDEH
S
T
L
I
---
K
R
------
E
F
A
S---------------
N
R
I
L
R
D
V
-
K
--
V
D
----
F
E
S
V
D
H
L
R
V
E
V
E
E
V
A
D
V
I
R
N
G
G
E
--
T
E
-
I
G
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
P
V
--