@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1964: (2016-03-30 )
MEAIKVESLTKNYHKKRAIENVDLSVNEGELYGFIGPNGAGKSTTIKVLLNFIYATSGGATILGKDVVKDSAEIKKMVGYVPSEVRYYPQMTANDIIHYAAKFHHIENATQKMNKYYEMFSIDPKKRFGEMSLGNKKKVAIVAGLITEPQLFILDEPTNGLDPLMQHYLFKEMTERNKEGMTIFLSSHNLREVQEYCTRAAFIRNGNIIAVEDIANQQMTGKVIALKGTNLPLEKLTNAGARIIEKEMGKARLIFDDDIKTILPLLQEKEITDLTITNQELEDKFMTLYEGGEIK
Atome Classification :
(21 SA)
-.........10...----.----....20........30........40........50........60......----.-.---70--.----.--..----...---..80-----....-.------------...90..--......100-.....--.--..--.--110....-----..-...120.-----..--.-...--.----------130.......140.......150.......160....---...170.....-.-.-180.......190.......200.......---210-.-----------........220...-....-230........240....----...250-----------.....--....260.......270.......280.------......290...------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ME
A
I
K
V
E
S
L
T
K
N
Y
H
----
K
----
K
RAIENV
D
L
S
VNE
G
E
L
Y
G
F
IGPNGAGK
S
T
T
I
K
V
L
L
N
F
I
YATSG
G
A
T
I
L
G
K
D
V----V-K---
D
---
S
----
A
--
E
I
----
K
K
M
---
V
GYV-----
P
S
E
V
-
R
------------YYPQM
T
A
--
N
D
I
I
H
Y
A
---
A
K
F
H
H
--
I
--
E
N
--
A
--
T
--
Q
K
M
N
-----
K
Y
-
Y
E
M
FS-I-----
D
P
--
K
-
K
RF--G----------EMSLGNK
K
K
V
A
I
V
A
GLITE
P
Q
L
F
I
L
DEPTN
G
L
D
P
L
M
Q
---
H
Y
L
F
K
E
M
T
E
RN-K-E-
G
M
T
I
F
LSSH
N
L
R
E
V
Q
E
Y
C
T
R
A
A
F
IRNG
N
I
I
---
A
---
V
-----------EDIANQQMT
G
K
V
I
A
-
L
KGT-NL-
P
L
E
K
L
TNA
G
A
R
I
I
E
K
----EMG
K
-------------
A
R
L
I
F--DD
D
I
K
T
I
L
P
L
L
QEKEIT
D
L
T
IT
N
Q
E
L
E
D
------
K
F
M
T
L
YEGGEIK------------------------------------------
40
HHSearch
88.31
34%
-93
- C1 -
1VPL
2
?
A:
[14-235]
--
G
A
V
V
V
K
D
L
R
K
R
I
G
----
K
----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
----
V
-
E
---
E
---
P
----
H
--
E
V
----
R
K
L
---
I
S
Y
L
-----
P
E
E
A
-
G
------------
A
Y
R
N
M
Q
G
--
I
E
Y
L
R
F
V
---
A
G
F
Y
A
--
S
--
S
S
--
S
E
I
E
--
E
M
V
E
-----
R
A
-
T
E
I
A
G
-
L
-----
G
E
KI
K
-
D
R
V
--
S
----------
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
---
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
---
E
---
T
-----------
G
T
V
E
E
L
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.26
35%
-96
- C1 -
1VPL
2
?
A:
[14-225]
--
G
A
V
V
V
K
D
L
R
K
R
I
G
----
K
----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
----
V
-
E
---
E
---
P
----
H
--
E
V
----
R
K
L
---
I
S
Y
L
-----
P
E
E
A
-
G
------------
A
Y
R
N
M
Q
G
--
I
E
Y
L
R
F
V
---
A
G
F
Y
A
--
S
--
S
S
--
S
E
I
E
--
E
M
V
E
-----
R
A
-
T
E
I
A
G
-
L
-----
G
E
KI
K
-
D
R
V
--
S
----------
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
---
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.44
30%
-107
- C1 -
4RVC
-
?
A:
[2-232]
--
T
L
L
E
V
K
D
L
S
G
G
Y
T
----
A
----
Q
N
V
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
S
I
N
G
Y
R
L
----
A
-
D
---
G
---
P
----
E
--
T
Y
----
R
R
Q
---
F
A
Y
I
-----
P
E
T
P
-
V
------------
L
Y
E
E
L
T
L
--
E
E
H
L
R
L
A
---
A
M
A
Y
G
--
L
--
S
E
--
A
--
E
Y
E
R
R
L
P
-----
P
L
-
L
R
E
F
R
-
L
-----
E
R
--
R
L
S
S
F
P-
A
----------
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
---
H
A
L
L
E
R
M
N
E
Q
K
-
A
-
K
-
G
A
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
---
A
KGT
L
-----------
D
D
I
R
R
Q
------
F
G
-
L
R
G
A
-
S
L
------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
79.82
23%
-72
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
K
KG--
K
----
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
-
S
---
N
---
G
----
K
--
L
I
VPPE
D
R
K
---
I
G
M
V
-----
F
Q
T
W
-
A
------------
L
Y
P
N
L
T
A
--
F
E
N
I
A
F
P
---
L
T
N
M
K
--
M
SK
E
E
--
I
--
R
--
K
R
V
E
-----
E
V
-
A
K
I
L
D
-
I
-----
H
H
VL
N
-
H
F
P
--
R
----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
---
D
S
A
R
A
L
V
K
E
V
Q
-
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
---
Q
---
V
GKP--------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
-
L
I
G
E
I
N
E
-
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
----
R
F
P
V
SVSSDRAIIGIRP
E
D
V
K
L
--
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
------
R
I
T
I
T
P
L
D
S
E
E
E
IFTYSDHPIHSGEEVLVYVRKDKIKVFEK-------------
11
PsiBlast_PDB
75.48
26%
-90
- C1 -
3D31
-
?
A:
[2-248]
----
I
E
I
E
S
L
S
R
K
W
-----
K
----
N
F
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
K
D
V
----
T
-
D
---
L
---
S
----
P
--
E
-----
K
H
D
---
I
A
F
V
-----
Y
Q
N
Y
-
S
------------
L
F
P
H
M
N
V
--
K
K
N
L
E
F
G
---
M
R
M
K
K
--
I
--
K
D
--
P
--
K
--
R
V
L
D
T
A
R
D
L
K
I
-
E
H
L
L
D
-
R
-----
N
P
--
L
-
T
----------------
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
-
K
----
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
---
Q
---
V
G
K
P--------
E
E
I
F
E
K
P
V
E
G
R
V
A
S
-
F
V
G
F
-
E
N
-
V
L
K
------
G
R
V
I
S
A
----
E
Q
G
L
-------------
L
R
I
--------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.29
30%
-91
- C1 -
2IT1
-
?
A:
[1-215]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
G
----
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
----
T
-
E
---
L
---
P
----
P
--
K
-----
D
R
N
---
V
G
L
V
-----
F
Q
N
W
-
A
------------
L
Y
P
H
M
T
V
--
Y
K
N
I
A
F
P
---
L
E
L
R
K
--
A
P
R
E
E
--
I
--
D
--
K
K
V
R
-----
E
V
-
A
K
M
L
H
-
I
-----
D
K
LL
N
-
R
Y
P
--
W
----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
---
L
E
V
R
A
E
L
K
R
L
Q
-
K
-
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
---
Q
---
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
74.68
25%
-97
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-233]
-
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
----
D
G---
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
----
D
-
Y
---
S
R
K
G
I
----
M
--
K
L
----
R
E
S
---
I
G
I
V
-----
F
Q
D
P
D
N
------------
Q
L
F
S
A
S
V
--
Y
Q
D
V
S
F
G
---
A
V
N
M
K
--
L
--
P
E
D
E
I
--
R
--
K
R
V
D
-----
N
A
-
L
K
R
T
G
-
I
-----
E
H
LK
D
-
K
P
T
--
H
----------
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
---
S
E
I
M
K
L
L
V
E
M
Q
K
E
-
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
---
L
---
Q
-----------
G
N
P
K
E
V
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.22
29%
-91
- C1 -
4U00
3
?
A:
[5-217]
----
I
R
I
R
N
L
H
K
W
F
G
----
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
-
D
---
D
---
R
----
A
L
R
E
I
----
R
R
E
---
V
G
M
V
-----
F
Q
Q
F
-
N
------------
L
F
P
H
M
T
V
--
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
--
R
--
E
K
--
A
--
E
--
K
K
A
L
-----
E
L
-
L
E
R
V
G
-
I
L----
D
Q
--
A
-
R
K
Y
P-
A
----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
74.02
29%
-84
- C1 -
2IT1
-
?
A:
[1-223]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
G
----
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
----
T
-
E
---
L
--------
P
--
P
K
----
D
R
N
---
V
G
L
V
-----
F
Q
N
W
-
A
------------
L
Y
P
H
M
T
V
--
Y
K
N
I
A
F
P
---
L
E
L
R
K
--
A
--
P
R
--
E
E
I
D
--
K
K
V
R
-----
E
V
-
A
K
M
L
H
-
I
-----
D
K
LL
N
-
R
Y
P
--
W
----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
---
L
E
V
R
A
E
L
K
R
L
Q
-
K
E
L
-
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
---
Q
---
V
-----------
G
T
P
D
E
V
Y
Y
--------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
73.85
25%
-100
- C1 -
3TUI
1
METN_ECOLI
C:
[23-253]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
GTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
----
T
-
T
---
L
---
S
ESEL
T
--
K
A
----
R
R
Q
---
I
G
M
I
-----
F
Q
H
F
-
N
------------
L
L
S
S
R
T
V
--
F
G
N
V
A
L
P
---
L
E
L
D
N
--
T
--
P
K
--
D
EV
K
--
R
R
V
T
-----
E
L
-
L
S
L
V
G
-
L
-----
G
D
KH
D
-
S
Y
P
--
S
----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
---
R
S
I
L
E
L
L
K
D
I
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
---
E
---
Q
-----------
D
T
V
S
E
V
F
S
--------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
73.21
22%
-85
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
----
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
TTLS
E
-
S
---
E
---
L
----
T
--
K
A
----
R
R
Q
---
I
G
M
I
-----
F
Q
H
F
-
N
------------
L
L
S
S
R
T
V
--
F
G
N
V
A
L
P
---
L
E
L
D
N
--
T
PK
D
E
--
V
--
K
--
R
R
V
T
-----
E
L
-
L
S
L
V
G
-
L
-----
G
D
--
K
-
H
D
S
YP
S
----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
---
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
EQD
T
---
V
-----------
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
-
F
I
Q
S
-
T
L
-
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
PFTD
C
V
P
M
-------------
L
R
L
E
F
TG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
AGGVKF
G
I
M
L
T
E
M
H
G
T
Q
Q
DTQAAIAWLQEHHVKVEV------------------------
10
PsiBlast_PDB
73.20
29%
-88
- C1 -
4U02
1
?
A:
[5-217]
----
I
R
I
R
N
L
H
K
W
F
G
----
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
-
D
---
D
---
R
----
A
L
R
E
I
----
R
R
E
---
V
G
M
V
-----
F
Q
Q
F
-
N
------------
L
F
P
H
M
T
V
--
L
E
N
V
T
L
A
PMR
V
R
R
W
P
--
R
--
E
K
--
A
--
E
--
K
K
A
L
-----
E
L
-
L
E
R
V
G
-
I
L----
D
Q
--
A
-
R
K
Y
P-
A
----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
72.24
19%
-76
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G---
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
-
G
G
K
R
----
V
-
T
---
D
---
L
----
P
--
P
Q
----
K
R
N
---
V
G
L
V
-----
F
Q
N
Y
-
A
------------
L
F
Q
H
M
T
V
--
Y
D
N
V
S
F
G
---
L
R
E
K
R
VP
K
--
D
E
--
M
--
D
--
A
R
V
R
-----
E
L
-
L
R
F
M
R
-
L
-----
E
S
YA
N
-
R
F
P
--
H
----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
---
R
E
L
R
T
F
V
R
Q
V
H
-
D
-
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
---
Q
---
F
G
T
P
--------
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
-
N
V
-
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
----
A
L
P
V
-------------
D
P
A
V
S
--
E
G
--
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
------
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
35
HHSearch
71.82
26%
-81
- C1 -
2OLJ
4
?
A:
[22-248]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----
K
-
A
KDT
N
---
L
----
N
--
K
V
----
R
E
E
---
V
G
M
V
-----
F
Q
R
F
-
N
------------
L
F
P
H
M
T
V
--
L
N
N
I
T
L
A
---
P
M
K
V
R
K-
W
--
P
R
E
K
A
--
E
--
A
K
A
M
-----
E
L
-
L
D
K
V
G
-
L
-----
K
D
KA
H
-
A
Y
P
--
D
----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
---
E
---
E
-----------
G
K
P
E
D
L
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
71.76
25%
-92
- C1 -
1JI0
1
?
A:
[5-228]
--
I
V
L
E
V
Q
S
L
H
V
Y
Y
G
----
A
----
I
H
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
N
G
Q
D
I
----
T
-
N
---
K
---
P
A
---
H
V
-
I
N
----
R
M
G
---
I
A
L
V
-----
P
E
G
R
-
R
------------
I
F
P
E
L
T
V
--
Y
E
N
L
M
M
G
---
A
Y
N
R
K
--
D
--
K
E
G
-
I
--
K
--
R
D
L
E
-----
W
I
-
F
S
L
F
P
R
L
-----
K
E
R
L
K
-
Q
L
G
--
G
----------
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
---
S
E
V
F
E
V
I
Q
K
I
N
-
Q
-
E
-
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
E
T
G
Q
I
V
---
L
---
E
-----------
G
K
A
S
E
L
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.85
29%
-91
- C1 -
4YMW
-
?
J:
[2-215]
----
I
F
V
N
D
V
Y
K
N
F
G
----
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
-
N
---
G
---
K
----
V
--
N
I
----
N
K
V
RQK
V
G
M
V
-----
F
Q
H
F
-
N
------------
L
F
P
H
L
T
A
--
I
E
N
I
T
L
A
---
P
V
------------
K
--
V
--
K
K
M
N
-----
K
K
E
A
E
E
L
A
-
V
-----
D
L
--
L
-
A
K
V
--
G
LLDKKDQYPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.85
29%
-96
- C1 -
1G6H
3
LIVG_METJA
A:
[5-233]
-
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
----
E
----
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
----
T
N
K
---
E
---
P
----
A
--
E
L
----
Y
H
Y
----
G
I
V
R
T
F
Q
T
P
Q
P
L
-
K
E
M
T
V
L
E
N
L
L
I
G
E
I
C
P
G
E
S
P
--
L
N
S
L
F
Y
K
---
K
W
I
P
K
--
E
--
E
E
--
M
--
V
--
E
K
A
F
-----
K
I
-
L
E
F
L
K
-
L
-----
S
H
LY
D
-
R
K
A
--
G
----------
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
---
H
D
I
F
N
H
V
L
E
L
K
-
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
---
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.46
29%
-89
- C1 -
4YMT
-
?
J:
[2-215]
----
I
F
V
N
D
V
Y
K
N
F
G
----
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
-
N
---
G
---
K
----
V
--
N
I
----
N
K
V
RQK
V
G
M
V
-----
F
Q
H
F
-
N
------------
L
F
P
H
L
T
A
--
I
E
N
I
T
L
A
---
P
V
------------
K
--
V
--
K
K
M
N
-----
K
K
E
A
E
E
L
A
-
V
-----
D
L
--
L
-
A
K
V
--
G
LLDKKDQYPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.28
29%
-90
- C1 -
4YMS
-
?
J:
[2-215]
----
I
F
V
N
D
V
Y
K
N
F
G
----
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
-
N
---
G
---
K
----
V
--
N
I
----
N
K
V
RQK
V
G
M
V
-----
F
Q
H
F
-
N
------------
L
F
P
H
L
T
A
--
I
E
N
I
T
L
A
---
P
V
------------
K
--
V
--
K
K
M
N
-----
K
K
E
A
E
E
L
A
-
V
-----
D
L
--
L
-
A
K
V
--
G
LLDKKDQYPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.40
29%
-87
- C1 -
4YMU
2
?
J:
[2-215]
----
I
F
V
N
D
V
Y
K
N
F
G
----
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
-
N
---
G
---
K
----
V
--
N
I
----
N
K
V
RQK
V
G
M
V
-----
F
Q
H
F
-
N
------------
L
F
P
H
L
T
A
--
I
E
N
I
T
L
A
---
P
V
------------
K
--
V
--
K
K
M
N
-----
K
K
E
A
E
E
L
A
-
V
-----
D
L
--
L
-
A
K
V
--
G
LLDKKDQYPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
---
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.78
30%
15
- C1 -
4YER
4
?
A:
[6-302]
----
I
V
V
E
N
L
V
K
K
F
G
----
D
----
F
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
H
D
V
----
L
-
K
---
E
---
P
----
R
--
E
V
----
R
R
K
---
I
G
I
V
-----
F
Q
D
Q
-
S
------------
L
D
R
E
L
T
A
Y
E
N
M
Y
I
H
G
K
---
I
Y
G
Y
G
--
G
--
E
K
--
L
--
K
--
K
R
I
L
-----
E
L
-
L
E
F
V
E
-
L
LEFKD
K
P
--
V
-
K
T
F
---------------
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
---
A
H
M
W
E
Y
I
S
K
M
K
-
K
-
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
---
A
---
L
GT
P
T
E
L
K
R
M
V
G
K
E
I
I
Y
V
R
-----------
D
-
F
I
E
S
C
R
K
L
P
D
G
R
L
E
L
N
V
E
----
D
--------------------------------------
I
E
E
I
T
Y
H
K
P
T
L
N
D
------
V
F
L
H
L
-------------------------------------------------