@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2075: (2016-03-31 )
VGGLMKKNTLILGIESSCDETAASVVKNGNEIISSVVASQIESHKRFGGVVPEIASRHHVEQITLVIEEALKQANVTMDDLDGVAVTEGPGLVGALLIGVNAAKTLAFMHNLPLVGVHHIAGHIYANRFETEFKFPLLSLVVSGGHTELVLMKADNEFEIIGETRDDAAGEAYDKVARTLGLAYPGGVQIDKLAKDGEDTFHFPRAMMDEGSFDFSFSGLKSSFINTLHNLRQRGEEPNPNDMAASFQASVVDVLVSKTIRAAKQYDVKQLLLAGGVAANQGLRERLIQEVKLELPETELIIPPLALCGDNAAMIAAAGTVSFLQGKRSGFDMNANPGLLLEDI
Atome Classification :
(22 SA)
.........10........20.....-...30........40....-...--.50........60........70........80........90........100.......110.......120.......130---...---.....140.......150.......160.......170.......180.......190-----......-.-----200........210----.......220.......230----...-....240.......250.......260....-----...270.......280.......290.......300--........310.......320.......330-...-....340..-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VGGLMKK
N
T
L
I
L
G
IESS
C
D
E
T
A
A
S
V
V
-KN
G
N
E
I
I
S
S
V
V
A
S
Q
I
E
S
H
K
-RFG--GV
V
P
E
I
A
SR
H
H
V
E
Q
I
T
L
V
I
E
E
A
L
K
QANVTMDDLD
G
V
A
VTEGP
G
L
V
G
A
L
L
IGV
N
A
A
K
T
L
A
F
M
HNLP
L
V
G
V
H
H
I
A
G
H
I
Y
A
N
RFE-T---EFK---
F
P
L
L
S
L
VVSGG
H
T
E
L
V
L
M
KADN
E
F
E
I
I
GETRDDAA
G
E
A
Y
D
K
V
A
R
T
LGLAYPGGV
Q
I
D
K
-----
L
AKDGE-D-----T-FH
F
P
R
A
M
MDEGS----FDFSF
S
G
L
K
S
S
F
I
N
T
L
H
N
L
R
----QRG-EEPN
P
N
D
M
A
A
S
F
Q
A
S
V
V
D
V
L
V
S
K
T
I
R
A
A
K
Q
Y
-----
D
V
K
Q
L
L
L
AGGVAA
N
Q
G
L
R
E
R
L
I
Q
E
V
K
LELPET
E
L
I---IP
P
L
A
LCGDN
A
A
M
I
A
AA
G
T
V
S
F
L
QGKRSGFD-MNA-NP
G
L
L
LEDI-----
4
PsiBlast_PDB
94.52
42%
-90
- C3 -
4WQ4
3
TSAD_ECOLI
A:
[3-334]
----------
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
E
L
-----
1
PsiBlast_PDB
94.36
42%
-89
- C3 -
3ZET
2
?
B:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
-----
M
A
S
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
------
N
G
G
-
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
-
V
T
V
-
R
P
R
W
P
L
A
E
L
-----
23
PsiBlast_CBE
94.29
42%
-88
- C3 -
4WQ4
4
TSAD_ECOLI
B:
[3-334]
----------
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
E
L
-----
3
PsiBlast_PDB
94.28
42%
-89
- C3 -
4YDU
7
TSAD_ECOLI
A:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
E
L
-----
21
PsiBlast_CBE
94.20
42%
-89
- C3 -
3ZEU
4
?
E:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
-----
M
A
S
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
------
N
G
G
-
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
-
V
T
V
-
R
P
R
W
P
L
A
E
L
-----
22
PsiBlast_CBE
94.18
42%
-87
- C3 -
4YDU
7
TSAD_ECOLI
B:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
E
L
-----
5
PsiBlast_PDB
94.18
42%
-88
- C3 -
4WQ5
5
TSAD_ECOLI
A:
[3-332]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
-------
24
PsiBlast_CBE
93.07
42%
-87
- C3 -
4WQ5
4
TSAD_ECOLI
B:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
-----
M
A
A
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
---
I
R
----
D
N
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
-
V
S
V
-
R
P
R
W
P
L
A
E
L
-----
2
PsiBlast_PDB
92.91
42%
-86
- C3 -
3ZEU
5
?
B:
[3-334]
----------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
-----
M
A
S
Q
G
T
A
G
-----
R
-
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
------
N
G
G
-
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
---
R
P
--
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
-
V
T
V
-
R
P
R
W
P
L
A
E
L
-----
36
HHSearch
91.64
42%
-88
- C3 -
3ZEU
5
?
B:
[1-334]
--------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
-
K
G
L
L
A
--
N
Q
L
Y
S
Q
V
K
L
H
A
D
YG
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
-
D
NPP
E
F
P
----
F
V
A
L
L
V
S
G
G
H
T
Q
-
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
-----
M
A
S
Q
G
T
-
A
-----
G
R
F
V
F
P
R
P
M
T
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
------
G
G
-
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
--
R
R
G
E
V
F
---
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
-
V
T
V
-
R
P
R
W
P
L
A
E
L
-----
6
PsiBlast_PDB
87.23
35%
-100
- C3 -
2IVN
3
KAE1_PYRAB
A:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
26
PsiBlast_CBE
87.16
35%
-103
- C3 -
2IVO
3
KAE1_PYRAB
C:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
27
PsiBlast_CBE
86.61
35%
-102
- C3 -
2IVO
2
KAE1_PYRAB
B:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
7
PsiBlast_PDB
86.47
35%
-102
- C3 -
2IVO
3
KAE1_PYRAB
A:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
8
PsiBlast_PDB
86.12
35%
-102
- C3 -
2IVP
2
KAE1_PYRAB
A:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
25
PsiBlast_CBE
85.99
35%
-104
- C3 -
2IVO
2
KAE1_PYRAB
D:
[2-301]
---------
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
----
Y
R
V
-
E
-----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
39
HHSearch
85.58
32%
-92
- C3 -
2IVN
3
KAE1_PYRAB
A:
[1-320]
--------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
-
K
V
L
A
N
V
F
-
D
T
L
T
T
E
K
-
G
G
----
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
-
G
---
V
K
D
----
P
V
G
L
Y
V
S
-
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
---
K
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
----------
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
--
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
E
T
I
V
-
K
Q
K
F
R
T
D
E
V
-----
9
PsiBlast_PDB
84.26
32%
-94
- C3 -
3WUH
2
QRI7_YEAST
A:
[7-363]
------
K
G
Y
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
N
V
L
A
N
L
K
D
T
L
D
-----------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
-
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
M
G
-
T
---
N
G
K
VPQ
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
K
---
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
D
I
N
-
D
QDFAL
K
-
L
E
M
P
--------RN
M
-
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
G
KT------
P
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
PEKFK
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
---------
F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
-
I
E
I
W
E
S
L
R
L
V
S
D
-
L
D
I
-
C
P
------------
57
Fugue
84.23
32%
-91
- C3 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
--------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
-
K
V
L
A
N
V
F
D
T
L
---
T
T
-
E
K
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
-
G
---
V
K
-----
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
-
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
-----
L
A
E
K
G
E
-
K
-----
Y
-
I
E
L
P
Y
A
V
K
---
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
----------
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
--
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
-
E
T
I
V
K
Q
K
F
R
T
D
E
V
EIVWH
28
PsiBlast_CBE
82.55
32%
-96
- C3 -
3WUH
2
QRI7_YEAST
B:
[7-363]
------
K
G
Y
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
N
V
L
A
N
L
K
D
T
L
------------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
-
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
M
G
-
T
---
N
G
K
VPQ
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
K
---
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
D
I
N
-
D
QDFA
L
K
-
L
E
M
P
S
-------KRN
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
G
KTEI
Q
E
L
-
P
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
PEKFK
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
---------
F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
-
I
E
I
W
E
S
L
R
L
V
S
D
-
L
D
I
-
C
P
------------
11
PsiBlast_PDB
82.36
31%
-89
- C3 -
2VWB
1
KAE1B_METJA
A:
[2-306]
---------
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
-
T
S
D
G
E
V
L
F
N
---
K
T
I
M
--------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
T
-
T
---
E
A
E
---
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
-
V
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
-----
L
A
R
K
G
K
-
K
-----
L
-
V
D
L
P
Y
T
V
---
K
G
----
M
D
I
A
F
S
G
L
L
T
A
A
M
R
A
-
Y
D
A
G
----
E
R
L
-
E
-----
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
T
-----
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
K
A
M
C
E
G
Q
N
V
D
F
Y
---
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
W
M
S
L
D
-------------------
30
PsiBlast_CBE
81.01
31%
-88
- C3 -
2VWB
1
KAE1B_METJA
B:
[2-320]
---------
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
-
T
S
D
G
E
V
L
F
N
---
K
T
I
M
--------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
T
-
T
---
E
A
E
---
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
-
V
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
-----
L
A
R
K
G
K
-
K
-----
L
-
V
D
L
P
Y
T
V
---
K
G
----
M
D
I
A
F
S
G
L
L
T
A
A
M
R
A
-
Y
D
A
G
----
E
R
L
-
E
-----
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
T
-----
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
--
K
A
M
C
E
G
Q
N
V
D
F
Y
---
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
W
M
S
L
D
-------------------