@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03520: (2016-06-06 )
MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIFAILNQHPIIQP
Atome Classification :
(20 SA)
----------------------------------------.........10-.........20-.........30...-.....40........-50...-..----...60........70.-..-..---...80........90.......-.-100..-.....110.......120.----.----.---.-----.----.-.--.---.---------130....-..----.-.----140-.----....--.---.---.-.-150...--------.--.---.----.--------160-------.-.----..---.-..---------.--.170-----.----.-....--...180.......190-.-.....-----------.200-....-...210.-.-.....220..--......230.......240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------
M
S
Q
L
F
K
SFDA--SE
K
T
Q
L
I
C
F
P--FAGGYSA
S
F
R
P
L
H
A
-
F
L
QGE
C
E
M
L
AAEPPG-HGTNQ-
T
S
----
A
I
E
D
L
E
E
L
T
D
L
Y
K
Q
EL-NL-RP---DR
P
F
V
L
F
GHSMGG
M
I
T
F
R
L
A
Q
K
-
L
-
E
REGI-F
P
Q
A
V
I
I
SAIQPPHI
Q
--
R
----
K
----
K
---V-----S----H-L--
P
---
D
---------
D
Q
-
F
L
D
H
-
I
I
----
Q
-L----G---G----M
P
A
E
--
L
---V---E-
N
-
K
E
V
M
S
F
--------
F
--
L
---
P
----
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--------
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---------
R
-
S
----
D
Y
---
R
-
A
L
---------
E
--
Q
F
-------
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----
L
-
Y
D
L
A
--
Q
I
Q
S
P
V
H
V
FNGL
D
D
K
K
-
C
-
I
R
D
A
E
-----------
G
W
K
K
-
W
A
KD-I
T
F
H
QFD-G-
G
H
M
F
L
LS-
Q
T
--
E
E
V
A
E
R
I
F
A
I
L
NQHPIIQP
4
PsiBlast_PDB
59.69
30%
-119
- C1 -
3FLA
1
?
A:
[20-235]
------------------------------------------------------
R
A
R
L
V
C
L
P
--
H
A
G
G
S
A
S
F
F
F
P
L
A
K
-
A
L
A
P
A
V
E
V
L
A
V
Q
Y
P
G
-
R
Q
D
R
R
H
E
P
----
P
V
D
S
I
G
G
L
T
N
R
L
L
E
V
L
-
R
P
-
F
G
---
D
R
P
L
A
L
F
G
H
S
M
G
A
I
I
G
Y
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L
A
L
R
-
M
-
P
E
A
G
L
P
A
P
V
H
L
F
A
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G
R
R
A
P
S
R
Y
--
R
----
D
----
D
D--
V
-----
R
----
G
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A
--
S
---
D
---------
E
R
-
L
V
A
E
-
L
R
----
K
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L
----
G
---
G
----
S
D
A
A
--
M
---
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---
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P
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L
L
A
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--------
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--
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----
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--------
I
---------
R
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----
D
Y
---
R
-
A
V
---------
E
--
T
Y
-------
R
----
H
-
E
P
G
R
--
R
V
D
C
P
V
T
V
F
T
G
D
H
D
P
R
-
V
S
V
G
E
A
R
-----------
A
W
E
E
-
H
T
T
G
P
A
D
L
R
V
L
P
-
G
-
G
H
F
F
L
V
D
-
Q
A
---------------------
3
PsiBlast_PDB
57.26
30%
-113
- C1 -
3FLB
2
?
A:
[20-235]
------------------------------------------------------
R
A
R
L
V
C
L
P
--
H
A
G
G
S
A
S
F
F
F
P
L
A
K
-
A
L
A
P
A
V
E
V
L
A
V
Q
Y
P
G
-
R
Q
D
R
R
H
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P
----
P
V
D
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G
L
T
N
R
L
L
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V
L
-
R
P
-
F
G
---
D
R
P
L
A
L
F
G
H
A
M
G
A
I
I
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Y
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L
A
L
R
-
M
-
P
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A
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L
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A
P
V
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L
F
A
S
G
R
R
A
P
S
R
Y
--
R
----
D
----
D
D--
V
-----
R
----
G
-
A
--
S
---
D
---------
E
R
-
L
V
A
E
-
L
R
----
K
-
L
----
G
---
G
----
S
D
A
A
--
M
---
L
---
A
-
D
-
P
E
L
L
A
M
--------
V
--
L
---
P
----
A
--------
I
---------
R
-
S
----
D
Y
---
R
-
A
V
---------
E
--
T
Y
-------
R
----
H
-
E
P
G
R
--
R
V
D
C
P
V
T
V
F
T
G
D
H
D
P
R
-
V
S
V
G
E
A
R
-----------
A
W
E
E
-
H
T
T
G
P
A
D
L
R
V
L
P
-
G
-
G
H
F
F
L
V
D
-
Q
A
---------------------
55
HHSearch
56.55
99%
-26
- C1 -
2K2Q
-
SRFAD_BACSU
B:
[1-242]
----------------------------------------
M
S
Q
L
F
K
S
F
D
A
--
S
E
K
T
Q
L
I
C
F
P
--
F
A
G
G
Y
S
A
S
F
R
P
L
H
A
-
F
L
Q
G
E
C
E
M
L
A
A
E
P
P
G
-
H
G
T
N
Q
-
T
S
----
A
I
E
D
L
E
E
L
T
D
L
Y
K
Q
E
L
-
N
L
-
R
P
---
D
R
P
F
V
L
F
G
H
S
M
G
G
M
I
T
F
R
L
A
Q
K
-
L
-
E
R
E
G
I
-
F
P
Q
A
V
I
I
S
A
I
Q
P
P
H
I
Q
--
R
----
K
----
K
---
V
-----
S
----
H
-
L
--
P
---
D
---------
D
Q
-
F
L
D
H
-
I
I
----
Q
-
L
----
G
---
G
----
M
P
A
E
--
L
---
V
---
E
-
N
-
K
E
V
M
S
F
--------
F
--
L
---
P
----
S
--------
F
---------
R
-
S
----
D
Y
---
R
-
A
L
---------
E
--
Q
F
-------
E
----
L
-
Y
D
L
A
--
Q
I
Q
S
P
V
H
V
F
N
G
L
D
D
K
K
C
I
-
R
-
D
A
E
-----------
G
W
K
K
-
W
A
K
D
-
I
T
F
H
Q
F
D
-
G
-
G
H
M
F
L
L
S
-
Q
T
--
E
E
V
A
E
R
I
F
A
I
L
N
Q
H
P
I
I
Q
P
45
Fugue
56.52
100%
-33
* C1 *
2RON
-
SRFAD_BACSU
A:
[1-242]
----------------------------------------
M
S
Q
L
F
K
S
F
D
A
--
S
E
K
T
Q
L
I
C
F
P
--
F
A
G
G
Y
S
A
S
F
R
P
L
H
A
-
F
L
Q
G
E
C
E
M
L
A
A
E
P
P
G
-
H
G
T
N
Q
-
T
S
----
A
I
E
D
L
E
E
L
T
D
L
Y
K
Q
E
L
-
N
L
-
R
P
---
D
R
P
F
V
L
F
G
H
S
M
G
G
M
I
T
F
R
L
A
Q
K
-
L
-
E
R
E
G
I
-
F
P
Q
A
V
I
I
S
A
I
Q
P
P
H
I
Q
--
R
----
K
----
K
---
V
-----
S
----
H
-
L
--
P
---
D
---------
D
Q
-
F
L
D
H
-
I
I
----
Q
-
L
----
G
---
G
----
M
P
A
E
--
L
---
V
---
E
-
N
-
K
E
V
M
S
F
--------
F
--
L
---
P
----
S
--------
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---------
R
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S
----
D
Y
---
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-
A
L
---------
E
--
Q
F
-------
E
----
L
-
Y
D
L
A
--
Q
I
Q
S
P
V
H
V
F
N
G
L
D
D
K
K
-
C
-
I
R
D
A
E
-----------
G
W
K
K
-
W
A
K
D
-
I
T
F
H
Q
F
D
-
G
-
G
H
M
F
L
L
S
-
Q
T
--
E
E
V
A
E
R
I
F
A
I
L
N
Q
H
P
I
I
Q
P
2
PsiBlast_PDB
56.27
100%
-24
- C1 -
2K2Q
-
SRFAD_BACSU
B:
[1-242]
----------------------------------------
M
S
Q
L
F
K
S
F
D
A
--
S
E
K
T
Q
L
I
C
F
P
--
F
A
G
G
Y
S
A
S
F
R
P
L
H
A
-
F
L
Q
G
E
C
E
M
L
A
A
E
P
P
G
-
H
G
T
N
Q
-
T
S
----
A
I
E
D
L
E
E
L
T
D
L
Y
K
Q
E
L
-
N
L
-
R
P
---
D
R
P
F
V
L
F
G
H
S
M
G
G
M
I
T
F
R
L
A
Q
K
-
L
-
E
R
E
G
I
-
F
P
Q
A
V
I
I
S
A
I
Q
P
P
H
I
Q
--
R
----
K
----
K
---
V
-----
S
----
H
-
L
--
P
---
D
---------
D
Q
-
F
L
D
H
-
I
I
----
Q
-
L
----
G
---
G
----
M
P
A
E
--
L
---
V
---
E
-
N
-
K
E
V
M
S
F
--------
F
--
L
---
P
----
S
--------
F
---------
R
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S
----
D
Y
---
R
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A
L
---------
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--
Q
F
-------
E
----
L
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Y
D
L
A
--
Q
I
Q
S
P
V
H
V
F
N
G
L
D
D
K
K
-
C
-
I
R
D
A
E
-----------
G
W
K
K
-
W
A
K
D
-
I
T
F
H
Q
F
D
-
G
-
G
H
M
F
L
L
S
-
Q
T
--
E
E
V
A
E
R
I
F
A
I
L
N
Q
H
P
I
I
Q
P
1
PsiBlast_PDB
56.27
100%
-33
- C1 -
2RON
-
SRFAD_BACSU
A:
[1-242]
----------------------------------------
M
S
Q
L
F
K
S
F
D
A
--
S
E
K
T
Q
L
I
C
F
P
--
F
A
G
G
Y
S
A
S
F
R
P
L
H
A
-
F
L
Q
G
E
C
E
M
L
A
A
E
P
P
G
-
H
G
T
N
Q
-
T
S
----
A
I
E
D
L
E
E
L
T
D
L
Y
K
Q
E
L
-
N
L
-
R
P
---
D
R
P
F
V
L
F
G
H
S
M
G
G
M
I
T
F
R
L
A
Q
K
-
L
-
E
R
E
G
I
-
F
P
Q
A
V
I
I
S
A
I
Q
P
P
H
I
Q
--
R
----
K
----
K
---
V
-----
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----
H
-
L
--
P
---
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---------
D
Q
-
F
L
D
H
-
I
I
----
Q
-
L
----
G
---
G
----
M
P
A
E
--
L
---
V
---
E
-
N
-
K
E
V
M
S
F
--------
F
--
L
---
P
----
S
--------
F
---------
R
-
S
----
D
Y
---
R
-
A
L
---------
E
--
Q
F
-------
E
----
L
-
Y
D
L
A
--
Q
I
Q
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P
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H
V
F
N
G
L
D
D
K
K
-
C
-
I
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A
E
-----------
G
W
K
K
-
W
A
K
D
-
I
T
F
H
Q
F
D
-
G
-
G
H
M
F
L
L
S
-
Q
T
--
E
E
V
A
E
R
I
F
A
I
L
N
Q
H
P
I
I
Q
P
63
HHSearch
54.37
17%
-119
- C1 -
4CCY
2
YBFK_BACSU
A:
[46-295]
--------------------------------------------
I
I
A
S
G
P
--
K
D
A
P
S
L
I
L
L
H
--
G
G
L
F
S
S
A
M
W
Y
P
N
I
A
-
A
W
S
S
Q
F
R
T
Y
A
V
D
I
I
G
-
D
K
N
K
S
I
P
S
A---
A
M
E
T
R
A
D
F
A
E
W
M
K
D
V
F
-
D
S
-
L
G
---
L
E
T
A
H
L
A
G
L
S
L
G
G
S
H
I
V
N
F
L
L
R
-
A
-
P
E
----
R
V
E
R
A
V
V
I
S
P
A
E
A
F
I
S
F-
H
----
P
----
D
---
V
-----
Y
K
Y
A
A
E
-
L
--
T
---
G
A
R
G
A
-----
E
S
-
Y
I
K
W
-
I
T
----
G
-
D
----
S
---
Y
----
D
L
H
P
--
L
---
L
---
Q
---
R
Q
I
V
A
G
--------
V
E
W
Q
DEQ
R
----
S
--------
L
---------
K
-
P
----
T
E
---
N
-
G
F
---------
P
--
Y
V
F
------
T
----
D
-
Q
E
L
K
--
S
I
Q
V
P
V
L
L
M
F
G
E
H
E
A
M
Y
H
-
Q
Q
M
A
F
E
----------
R
A
S
V
-
L
V
P
G
-
I
Q
A
E
I
V
K
-
N
A
G
H
L
L
S
L
E
-
Q
P
--
E
Y
V
N
Q
R
V
L
S
F
L
C
G
G
I
----
65
HHSearch
54.10
15%
-133
- C1 -
3BF7
-
YBFF_ECOLI
A:
[14-254]
----------------------------------------------------
H
N
N
S
P
I
V
L
V
H
--
G
L
F
G
S
L
D
N
L
G
V
L
A
R
-
D
L
V
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D
H
N
I
I
Q
V
D
V
R
N
-
H
G
L
S
P
-
R
E
----
P
V
M
N
Y
P
A
M
A
Q
D
L
V
D
T
L
-
D
A
-
L
Q
---
I
D
K
A
T
F
I
G
H
S
M
G
G
K
A
V
M
A
L
T
A
L
-
A
-
P
D
----
R
I
D
K
L
V
A
I
D
I
A
P
V
D
Y
H
V-
R
RH
D
-
E
----
I
F
A
A
I
-----
N
----
A
-
V
--
S
---
E
S
--------
D
A
Q
T
R
Q
Q
-
A
A
----
A
-
I
-------------
M
-
R
Q
--
H
---
L
---
N
-
E
-
E
G
V
I
Q
F
--------
L
--
L
---
K
----
S
--------
F
VDGEW----
R
-
F
----
N
V
---
P
V
L
W
---------
D
--
Q
Y
-------
P
H
I
V
G
W
-
E
K
I
P
--
A
W
D
H
P
A
L
F
I
P
G
G
N
S
P
Y
V
S
-
E
Q
Y
R
D
-----------
D
L
L
A
-
Q
F
P
Q
-
A
R
A
H
V
I
A
G
A
-
G
H
W
V
H
A
E
-
K
P
--
D
A
V
L
R
A
I
R
R
Y
L
N
D
------
72
HHSearch
52.99
12%
-137
- C1 -
3QVM
4
?
A:
[27-278]
-----------------------------------------------------
G
E
K
T
V
L
L
A
H
--
G
F
G
C
D
Q
N
M
W
R
F
M
L
P
-
E
L
E
K
Q
F
T
V
I
V
F
D
Y
V
G
-
S
G
Q
S
D
L
E
S
FSTK
R
Y
S
S
L
E
G
Y
A
K
D
V
E
E
I
L
-
V
A
-
L
D
---
L
V
N
V
S
I
I
G
H
S
V
S
S
I
I
A
G
I
A
S
T
H
-
V
-
G
D
----
R
I
S
D
I
T
M
I
C
P
S
P
C
F
M
N
FP
P
----
D
YVG-
G
---
F
-----
E
----
R
-
D
--
D
---
L
---------
E
E
-
L
I
N
L
-
M
D
K
N
Y
I
G
-
W
----
A
---
N
Y
---
L
A
P
L
--
V
MGA
S
---
H
-
S
-
S
E
L
I
G
E
--------
L
--
S
---
G
----
S
--------
F
---------
C
T
T
----
D
P
I
V
A
K
-
T
F
A
--------
K
A
T
F
F
-------
S
D---
Y
R
S
L
L
E
--
D
I
S
T
P
A
L
I
F
Q
S
A
K
D
S
L
A
S
-
P
E
V
G
Q
-----------
Y
M
A
E
-
N
I
P
N
-
S
Q
L
E
L
I
Q
-
A
E
G
H
C
L
H
M
T
-
D
A
--
G
L
I
T
P
L
L
I
H
F
I
Q
N
N
-----
64
HHSearch
52.94
17%
-115
- C1 -
4PW0
6
?
A:
[28-282]
--------------------------------------------
Y
R
S
L
G
A
--
P
S
D
I
P
L
I
C
F
Q
--
H
F
T
G
T
L
D
N
W
D
P
L
I
T
N
G
L
S
K
G
R
Q
L
I
I
F
D
N
K
G
-
V
G
L
S
S
-
G
T
----
T
P
D
N
V
A
A
M
T
A
D
A
L
E
F
I
-
T
A
-
L
G
---
I
R
Y
F
D
V
L
G
F
S
L
G
G
F
I
V
Q
Y
M
A
H
I
-
Q
-
P
D
----
M
I
R
K
I
I
I
V
G
A
A
P
Q
G
V
K
V-
L
HT
F
-
P
D
---
L
---
I
-----
A
R
A
M
-
Q
-
L
--
E
P--
K
---------
E
R
-
F
L
F
I
-
F
F
----
E
-
Q
S---
E
---
H
----
S
R
S
K
--
G
---
L
---
A
T
L
-
G
R
L
Y
E
R
TTDRDQDA
S
--
A
---
Q
----
A
--------
I
---------
G
-
A
----
Q
L
---
T
-
A
I
---------
T
--
N
W
-------
G
K
KTP
S
-
F
E
I
T
--
S
I
Q
H
P
V
F
V
V
Q
G
S
N
D
E
M
M
D
-
T
Y
N
S
Y
-----------
E
L
F
K
-
Q
L
P
D
-
A
I
L
S
L
Y
P
-
D
A
A
H
G
S
F
Y
Q
-
Y
P
--
E
L
F
V
S
Q
T
E
Y
F
L
D
S
------
58
HHSearch
52.63
14%
-105
- C1 -
2XUA
-
?
A:
[17-264]
---------------------------------------------
R
I
D
G
E
RH
G
N
A
P
W
I
V
L
S
N
--
S
L
G
T
D
L
S
M
W
A
P
Q
V
A
-
A
L
S
K
H
F
R
V
L
R
Y
D
T
R
G
-
H
G
H
S
E
A
P
K
----
G
P
Y
T
I
E
Q
L
T
G
D
V
L
G
L
M
-
D
T
-
L
K
---
I
A
R
A
N
F
C
G
L
S
M
G
G
L
T
G
V
A
L
A
A
R
-
H
-
A
D
----
R
I
E
R
V
A
L
C
N
T
A
A
R
I
G
S
--
P
----
E
V
W
V
P
R
---
A
-----
V
----
K
A
R
T
-
E
G--
M
---------
H
A
-
L
A
D
A
V
L
P
----
R
-
W
----
F
---
T
----
A
-
D
Y
--
M
---
E
---
R
-
E
-
P
V
V
L
A
M
--------
I
--
R
---
D
----
V
F
V
H
TD
K
E
G
Y
---------
A
-
S
----
N
C
---
E
-
A
I
---------
D
--
A
A
-------
D
L---
R
-
P
E
A
P
--
G
I
K
V
P
A
L
V
I
S
G
T
H
D
L
A
A
T
-
P
A
Q
G
R
-----------
E
L
A
Q
-
A
I
A
G
-
A
R
Y
V
E
L
D
-
A
-
S
H
I
S
N
I
E
-
R
A
--
D
A
F
T
K
T
V
V
D
F
L
T
E
------
7
PsiBlast_PDB
51.72
29%
-140
- C1 -
4XJV
1
SAST_HUMAN
A:
[31-252]
-------------------------------------------------
A
--
T
F
K
--
L
I
C
F
P
--
W
M
G
G
G
S
T
H
F
A
K
W
G
Q
-
D
T
H
D
L
L
E
V
H
S
L
-----------------------
Q
L
V
D
--
E
V
V
C
-
A
L
-
Q
P
VIQ
D
K
P
F
A
F
F
G
H
S
M
G
S
Y
I
A
F
R
T
A
L
G
-
L
K
E
N
N
Q
P
-
E
P
L
H
L
F
L
S
S
A
T
P
V
H
S
K
--
A
WHRI
P
----
K
---
D
-----
D
----
E
-
L
--
S
---
E
---------
E
Q
-
I
S
H
Y
-
L
M
----
E
-
F
-----------------------
A
---
E
-
A
-
K
E
F
V
K
Q
--------
C
--
S
---
P
----
I
--------
I
---------
R
-
A
----
D
L
---
N
-
I
V
---------
R
--
S
C
T
S-----
N
----
V
-
P
S
K
A
--
V
L
S
C
D
L
T
C
F
V
G
S
E
D
---
I
-
A
K
D
M
E
-----------
A
W
K
D
V
T
S
G
N
-
A
K
I
Y
Q
L
P
-
G
-
G
H
F
Y
L
L
D
-
P
A
--
N
E
-----------------
71
HHSearch
51.42
16%
-129
- C1 -
3V48
5
RUTD_ECOSE
A:
[8-261]
---------------------------------------------
S
P
P
P
Y
--
A
D
A
P
V
V
V
L
I
S
--
G
L
G
G
S
G
S
Y
W
L
P
Q
L
A
-
V
L
E
Q
E
Y
Q
V
V
C
Y
D
Q
R
G
-
T
G
N
N
P
D
T
L
A
---
E
D
Y
S
I
A
Q
M
A
A
E
L
H
Q
A
L
-
V
A
-
A
G
---
I
E
H
Y
A
V
V
G
H
A
L
G
A
L
V
G
M
Q
L
A
L
D
-
Y
-
P
A
----
S
V
T
V
L
I
S
V
N
G
W
L
R
I
N
A
H
-
T
R
---
R
----
C
---
F
-----
Q
V
R
E
-
R
-
L
--
L
---
Y
S
GG
A
-----
Q
A
-
W
V
E
A
-
Q
P
----
L
-
F
LYP
A
D
---
W
----
M
A
A
R
A
P
R
---
L
---
E
-
A
-
E
D
A
L
A
L
A
H
------
F
--
Q
---
G
K
N
--
N
--------
L
---------
L
-
R
----
R
L
---
N
-
A
L
---------
K
--
R
A
-------
D
----
F
S
H
H
A
D
--
R
I
R
C
P
V
Q
I
I
C
A
S
D
D
L
L
V
P
-
T
A
C
S
S
-----------
E
L
H
A
-
A
L
P
D
-
S
Q
K
M
V
M
P
Y
G
-
G
H
A
C
N
V
T
-
D
P
--
E
T
F
N
A
L
L
L
N
G
L
A
S
L
L
----
66
HHSearch
51.34
12%
-117
- C1 -
4CFS
6
HOD_ARTNT
A:
[29-285]
--------------------------------------------
Y
I
D
N
Q
R
D-
T
D
G
P
A
I
L
L
L
P
--
G
W
C
H
D
H
R
V
Y
K
Y
L
I
Q
-
E
L
D
A
D
F
R
V
I
V
P
N
W
R
G
-
H
G
L
S
P
S
E
V
----
P
D
F
G
Y
Q
E
Q
V
K
D
A
L
E
I
L
-
D
Q
-
L
G
---
V
E
T
F
L
P
V
S
H
S
H
G
G
W
V
L
V
E
L
L
E
Q
A
G
-
P
E
----
R
A
P
R
G
I
I
M
D
W
L
M
W
A
P
K
--
P
D
F
A
-
K
----
S
---
L
-----
T
----
L
-
L
--
K
---
D
PER
W
-----
R
E
G
T
H
G
L
-
F
D
----
V
-
W
L
---
D
---
G
----
H
D
E
K
--
R
---
V
---
R
---
H
H
L
L
E
E
--------
M
--
A
---
D
YG
Y
D
C
--------
W
---------
G
-
R
----
S
G
---
R
V
I
E
---------
D
--
A
Y
-------
G
R
NGS
P
M
Q
M
M
A
N
L
T
K
T
R
P
I
R
H
I
F
S
Q
P
T
E
P
E
Y
-
E
K
I
N
S
-----------
D
F
A
E
-
Q
H
P
W
-
F
S
Y
A
K
L
G
-
G
P
T
A
F
P
A
I
D
-
V
P
--
D
R
A
A
V
H
I
R
E
F
A
T
A
I
R
Q
---
56
HHSearch
50.76
17%
-120
- C1 -
3OM8
2
?
A:
[19-266]
--------------------------------------------
Y
R
L
D
G
A
--
A
E
K
P
L
L
A
L
S
N
--
S
I
G
T
T
L
H
M
W
D
A
Q
L
P
-
A
L
T
R
H
F
R
V
L
R
Y
D
A
R
G
-
H
G
A
S
S
V
P
P
----
G
P
Y
T
L
A
R
L
G
E
D
V
L
E
L
L
-
D
A
-
L
E
---
V
R
R
A
H
F
L
G
L
S
L
G
G
I
V
G
Q
W
L
A
L
H
-
A
-
P
Q
----
R
I
E
R
L
V
L
A
N
T
S
A
W
L
G
P
A-
A
Q
W
D
-
E
----
R
---
I
-----
A
----
A
V
L
--
Q
---
A
---------
E
D
-
M
S
E
T
-
A
A
----
G
F
L
----
G
---
N
W
---
F
P
P
A
--
L
---
L
E
--
R
-
A
-
E
P
V
V
E
R
--------
F
--
R
---
A
----
M
L
M
A
T----
N
---------
R
-
H
G
L
A
G
S
F
---
A
-
A
V
---------
R
--
D
T
-------
D
L---
R
-
A
Q
L
A
--
R
I
E
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
-
A
S
H
G
E
-----------
L
I
A
A
-
S
I
A
G
-
A
R
L
V
T
L
P
-
A
-
V
H
L
S
N
V
E
-
F
P
--
Q
A
F
E
G
A
V
L
S
F
L
G
A
------
14
PsiBlast_PDB
50.75
21%
-139
- C1 -
3TEJ
-
ENTF_ECOLI
A:
[1068-1293]
---------------------------------------------------------
L
F
C
F
H
--
P
A
S
G
F
A
W
Q
F
S
V
L
S
R
-
Y
L
D
P
Q
W
S
I
I
G
I
Q
S
P
R
P
N
G
P
M
Q
-
T
A
----
A
--
N
L
D
E
V
C
E
A
H
L
A
T
L
L
E
Q
-
Q
P
---
H
G
P
Y
Y
L
L
G
Y
S
L
G
G
T
L
A
Q
G
I
A
A
R
-
L
-
R
A
R
G
E
-
Q
V
A
F
L
G
L
L
D
T
W
P
P
E
T
Q
NW
Q
--------------------------
G
--
L
---
D
---------
P
E
-
V
L
A
E
-
I
-------------------------------------
N
-
R
E
R
E
A
F
--------
L
--
A
---
A
QQG-
S
--------
T
---------
S
-
T
----
E
L
---
F
-
T
T
---------
I
--
E
G
-------
N
----
Y
-
A
D
A
V
--
R
L
L
T
T
A
H
S
V
P
-
F
D
G
K
A
-
T
-
L
F
V
A
E
RTLQEGMS
P
E
R
A
W
S
P
-
W
I
A
E
-
L
D
I
Y
R
Q
D
-
C
-
A
H
V
D
I
I
S
-
P
G
TF
E
K
I
G
P
I
I
R
A
T
L
N
R
------
73
HHSearch
50.35
15%
-131
- C1 -
1WOM
10
RSBQ_BACSU
A:
[14-270]
---------------------------------------------
K
V
K
G
S
---
G
K
A
S
I
M
F
A
P
--
G
F
G
C
D
Q
S
V
W
N
A
V
A
P
-
A
F
E
E
D
H
R
V
I
L
F
D
Y
V
G
-
S
G
H
S
D
L
R
A
YDLN
R
Y
Q
T
L
D
G
Y
A
Q
D
V
L
D
V
C
-
E
A
-
L
D
---
L
K
E
T
V
F
V
G
H
S
V
G
A
L
I
G
M
L
A
S
I
R
-
R
-
P
E
----
L
F
S
H
L
V
M
V
G
P
S
P
C
Y
L
N
D-
P
P---
E
YYG-
G
---
F
-----
E
----
E
-
E
--
Q
---
L
---------
L
G
-
L
L
E
M
-
M
E
----
K
N
Y
----
I
---
G
W
A
T
V
F
A
A
T
--
V
---
L
NQP
D
-
R
-
P
E
I
K
E
E
--------
L
--
E
---
S
----
R
--------
F
---------
C
S
T
----
D
P
---
V
-
I
A
---------
R
--
Q
F
A
K
A
A
F
F
S
D
H---
R
-
E
D
L
S
--
K
V
T
V
P
S
L
I
L
Q
C
A
D
D
I
I
A
P
-
A
T
V
G
K
-----------
Y
M
H
Q
-
H
L
P
Y
-
S
S
L
K
Q
M
E
-
A
R
G
H
C
P
H
M
S
-
H
P
--
D
E
T
I
Q
L
I
G
D
Y
L
K
A
H
-----
74
HHSearch
49.95
15%
-125
- C1 -
3WI7
3
DHAA_AGRFC
A:
[34-302]
--------------------------------------------
T
V
E
H
G
----
S
G
A
P
I
V
F
L
H
--
G
N
P
T
S
S
Y
L
W
R
H
I
F
R
-
R
L
H
G
H
G
R
L
L
A
V
D
L
I
G
-
Y
G
Q
S
S
K
P
D
----
I
E
Y
T
L
E
N
Q
Q
R
Y
V
D
A
W
F
-
D
A
-
L
D
---
L
R
N
V
T
L
V
L
Q
D
Y
G
A
A
F
G
L
N
W
A
S
R
-
N
-
P
D
----
R
V
R
A
V
A
F
F
E
P
V
L
R
N
I
D
S-
V
DLS-
P
----
E
---
F
V
T
R
R
-
A
----
K
-
L
R
Q
P
---
G
E
G
E
I
F
V
QQE
N
R
-
F
L
T
E
-
L
F
----
P
-
W
----
F
---
F
----
L
--
T
--
P
---
L
---
A
---
P
E
D
L
R
Q
--------
Y
--
Q
---
T
----
P
--------
F
PTPHSR
K
A
I
L
-
A
----
G
P
---
R
-
N
L
PVDGEP
A
S
T
V
--
A
F
L
E
-----
Q
A---
V
-
N
W
L
N
--
T
S
D
T
P
K
L
L
L
T
F
K
P
G
F
L
L
T
-
D
A
I
L
K
-----------
W
S
Q
V
-
T
I
R
N
-
L
E
I
E
A
A
G
-
A
G
I
H
F
V
Q
E
E
-
Q
P
--
E
T
I
A
R
L
L
D
A
W
L
T
R
I
A
----
68
HHSearch
49.84
15%
-127
- C1 -
4NMW
2
BIOH_SALTY
A:
[9-258]
--------------------------------------------
W
Q
T
Y
G
E
---
G
N
C
H
L
V
L
L
H
--
G
W
G
L
N
A
E
V
W
H
C
I
R
E
-
E
L
G
S
H
F
T
L
H
L
V
D
L
P
G
-
Y
G
R
S
S
-
G
F
----
G
A
M
T
L
E
E
M
T
A
Q
V
A
K
N
------
A
---
P
D
Q
A
I
W
L
G
W
S
L
G
G
L
V
A
S
Q
M
A
L
T
-
H
-
P
E
----
R
V
Q
A
L
V
T
V
A
S
S
P
C
F
S
A
R-
E
GW--
P
----
G
---
I
K
P
E
I
L
G
----
G
-
F
--
Q
Q
Q
L
S
---------
D
D
-
F
Q
R
T
-
V
E
----
R
-
F
----
L
A
L
Q
T
----
L
G
T
E
--
T
---
A
R
--
Q
-
D
A
R
T
L
K
S
V
--------
V
L
-
A
Q
PM
P
D
V
E
-
V
--------
L
---------
N
-
G
----
G
L
---
E
-
I
L
---------
K
--
T
V
-------
D
----
L
R
E
A
L
K
--
N
V
N
M
P
F
L
R
L
Y
G
Y
L
D
G
L
V
P
-
R
K
I
V
P
-----------
L
L
D
T
-
L
W
P
H
-
S
T
S
Q
I
M
A
-
K
A
A
H
A
P
F
I
S
-
H
P
--
A
A
F
C
Q
A
L
M
T
L
K
S
S
------
54
Fugue
49.03
17%
-120
- C1 -
1KEZ
-
ERYA3_SACER
A:
[15-281]
SSA
L
R
D
G
Y
R
Q
A
G
V
S
GRV
R
S
Y
L
D
L
L
A
G
L
S
D
F
REHFDGS
D
G
F
S
L
D
L
V
D
M
A
D
G
--
P
G
E
V
T
V
I
C
C
A
G
T
A
A
I
S
G
P
H
E
F
T
R
L
A
G
-
A
L
R
G
I
A
P
V
R
A
V
P
Q
P
G
-
Y
E
E
G
E
--
P
----
L
P
S
S
M
A
A
V
A
A
V
Q
A
D
A
V
-
I
R
T
Q
G
---
D
K
P
F
V
V
A
G
H
S
A
G
A
L
M
A
Y
A
L
A
T
E
-
L
-
L
D
R
G
H
-
P
P
R
G
V
V
L
I
D
V
Y
P
P
G
H
Q
--
D
----
A
----
M
---
N
-----
A
----
W
-
L
--
E
---
E
---------
L
T
-
A
T
L
F
---------------------------------------
D
-
R
E
T
V
R
M
--------
D
--
D
---
T
----
R
--------
L
---------
T
-
A
----
L
G
---
A
-
Y
D
---------
R
--
L
T
-------
G
----
Q
-
W
R
P
R
--
E
T
G
L
P
T
L
L
V
S
A
G
E
P
M
G
-
P
-
W
P
D
D
S
-----------
W
K
P
T
-
W
P
F
E
-
H
D
T
V
A
V
P
-
G
-
D
H
F
T
M
V
Q
E
H
A
--
D
A
I
A
R
H
I
D
A
W
L
G
G
G
-----