@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22140: (2016-07-04 )
MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSHTSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREKAEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYTASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGRWGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR
Atome Classification :
(25 SA)
.........10........20........30........40..-..-....50........60..-......70----...---.....80.-.-.-.....90........100.......110.......120.......130....-..-.-140.......150.--......160.......170.......180.......190.......200....---...210.......220.......230.......240.......250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGYLH
D
A
FSLKG
K
T
A
L
V
TGPGT
G
I
G
Q
G
I
A
K
A
L
AGAGA
D
I
IGTS-HT-
S
S
L
S
E
T
Q
Q
L
V
E
QEG
R
I
F
T
-
S
F
T
LDMSK----
P
E
A
---
I
K
D
S
A
A
E
L
-
F
-E-NR
Q
I
D
I
L
VNNAG
I
I
H
R
E
K
A
EDF
P
E
E
N
W
Q
H
V
L
NVNL
N
S
L
F
I
L
T
Q
L
A
G
R
H
M
L
K
R-GH-
G
-
K
I
I
N
I
A
S
L
L
SFQG
G
--
I
L
V
P
AYTAS
K
H
A
V
A
G
L
T
K
S
F
A
N
E
W
A
AS
G
I
Q
V
N
A
IAPGYISTANTKPIRD
D
E
KR---
N
E
D
I
L
K
RIPAGRWGQADDIGG
T
A
V
F
L
A
S
R
A
S
DYVN
G
H
I
L
A
VDGGWLSR
123
HHSearch
91.82
49%
-107
- C1 -
3UF0
1
?
A:
[26-272]
------
P
F
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
-
D
G
V
K
E
V
A
D
E
I
A
D
G
G
G
S
A
E
-
A
V
V
A
D
L
A
D
----
L
E
G
---
A
A
N
V
A
E
E
L
-
A
-
A
-
T
R
R
V
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
-
G
S
-
G
-
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
--
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
---
A
A
E
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-
4
PsiBlast_PDB
91.46
49%
-107
- C1 -
3UF0
1
?
A:
[27-272]
-------
F
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
-
D
G
V
K
E
V
A
D
E
I
A
D
G
G
G
S
A
E
-
A
V
V
A
D
L
A
D
----
L
E
G
---
A
A
N
V
A
E
E
L
-
A
-
A
-
T
R
R
V
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
-
G
S
-
G
-
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
--
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
---
A
A
E
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-
26
PsiBlast_CBE
91.24
49%
-106
- C1 -
3UF0
1
?
B:
[27-272]
-------
F
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
-
D
G
V
K
E
V
A
D
E
I
A
D
G
G
G
S
A
E
-
A
V
V
A
D
L
A
D
----
L
E
G
---
A
A
N
V
A
E
E
L
-
A
-
A
-
T
R
R
V
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
-
G
S
-
G
-
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
--
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
---
A
A
E
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-
114
HHSearch
86.61
55%
-48
- C1 -
4ZA2
-
?
A:
[5-253]
------
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
K
-
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
----
V
S
G
---
H
A
E
L
V
E
K
A
-
V
-
A
E
F
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
G
K
G
-
G
-
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
22
PsiBlast_CBE
86.21
54%
-35
- C1 -
4Z9Y
1
?
D:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSGH
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
25
PsiBlast_CBE
85.92
54%
-55
- C1 -
4HP8
1
?
B:
[2-247]
----
K
N
P
F
S
L
E
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
A
G
A
E
V
V
C
A
A
-
R
R
-
A
P
-
D
E
T
L
D
I
I
A
K
D
G
G
N
A
S
-
A
L
L
I
D
F
A
D
----
P
L
A
---
A
K
D
S
-----
F
-
T
-
D
A
G
F
D
I
L
V
N
N
A
G
I
I
R
R
A
D
S
V
E
F
S
E
L
D
W
D
E
V
M
D
V
N
L
K
A
L
F
F
T
T
Q
A
F
A
K
E
L
L
A
K
-
G
R
S
G
-
K
V
V
N
I
A
S
L
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
T
E
A
L
R
A
D
A
A
R
---
N
K
A
I
L
E
R
I
P
A
G
R
W
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
A
A
A
D
Y
V
H
G
A
I
L
N
V
D
G
G
W
L
A
R
3
PsiBlast_PDB
85.76
54%
-55
- C1 -
4HP8
2
?
A:
[3-247]
-----
N
P
F
S
L
E
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
A
G
A
E
V
V
C
A
A
-
R
R
-
A
P
-
D
E
T
L
D
I
I
A
K
D
G
G
N
A
S
-
A
L
L
I
D
F
A
D
----
P
L
A
---
A
K
D
S
-----
F
-
T
-
D
A
G
F
D
I
L
V
N
N
A
G
I
I
R
R
A
D
S
V
E
F
S
E
L
D
W
D
E
V
M
D
V
N
L
K
A
L
F
F
T
T
Q
A
F
A
K
E
L
L
A
K
-
G
R
S
G
-
K
V
V
N
I
A
S
L
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
T
E
A
L
R
A
D
A
A
R
---
N
K
A
I
L
E
R
I
P
A
G
R
W
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
A
A
A
D
Y
V
H
G
A
I
L
N
V
D
G
G
W
L
A
R
2
PsiBlast_PDB
84.87
54%
-36
- C1 -
4ZA2
-
?
A:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSG
H
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
24
PsiBlast_CBE
84.12
54%
-37
- C1 -
4Z9Y
1
?
B:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSGH
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
23
PsiBlast_CBE
84.12
54%
-35
- C1 -
4Z9Y
1
?
C:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSGH
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
1
PsiBlast_PDB
83.98
54%
-33
- C1 -
4Z9Y
1
?
A:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSG
H
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
21
PsiBlast_CBE
83.12
54%
-37
- C1 -
4ZA2
1
?
D:
[4-253]
-----
N
S
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
-
I
V
-
E
P
-
K
D
T
I
E
K
V
T
A
L
G
R
R
F
L
-
S
L
T
A
D
M
S
N
VSGH
A
E
L
---
V
E
K
A
V
A
E
F
------
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
------
E
R
---
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
R
126
HHSearch
82.58
55%
-55
- C1 -
4HP8
2
?
A:
[4-246]
------
P
F
S
L
E
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
A
G
A
E
V
V
C
A
A
-
R
R
-
A
P
D
-
E
T
L
D
I
I
A
K
D
G
G
N
A
S
-
A
L
L
I
D
F
A
D
----
P
L
A
---
A
K
D
S
F
T
D
-------
A
G
F
D
I
L
V
N
N
A
G
I
I
R
R
A
D
S
V
E
F
S
E
L
D
W
D
E
V
M
D
V
N
L
K
A
L
F
F
T
T
Q
A
F
A
K
E
L
L
A
K
G
R
S
-
G
-
K
V
V
N
I
A
S
L
L
S
F
Q
G
G
--
I
R
V
P
S
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
T
E
A
L
R
A
D
A
A
R
---
N
K
A
I
L
E
R
I
P
A
G
R
W
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
A
A
A
D
Y
V
H
G
A
I
L
N
V
D
G
G
W
L
A
-
32
PsiBlast_CBE
74.95
41%
-25
- C1 -
4G81
1
?
A:
[5-253]
-------
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
-
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
-
G
V
A
F
D
V
T
D
----
E
L
A
---
I
E
A
A
F
S
K
L
D
A
-
E
-
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
-
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
--
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
F
---
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
-
30
PsiBlast_CBE
74.76
41%
-24
- C1 -
4G81
1
?
C:
[5-253]
-------
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
-
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
-
G
V
A
F
D
V
T
D
----
E
L
A
---
I
E
A
A
F
S
K
L
D
A
-
E
-
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
-
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
--
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
F
---
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
-
121
HHSearch
74.60
43%
-16
- C1 -
4J2H
7
?
A:
[6-255]
-----
P
I
F
D
L
S
G
R
R
A
L
V
T
G
A
S
R
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
T
A
-
R
T
V
E
G
L
A
E
T
R
A
L
I
E
K
T
G
R
R
A
V
-
A
L
A
Q
D
V
R
D
----
V
E
A
---
C
A
S
V
T
R
A
A
-
A
-
E
G
L
G
G
L
D
I
L
V
N
N
A
G
F
E
N
V
R
P
S
F
D
V
D
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
I
M
A
D
A
-
N
G
-
G
-
A
I
V
N
L
C
S
L
T
S
Y
V
G
I
--
P
T
A
V
P
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
W
A
A
H
N
I
R
V
N
A
I
A
P
G
Y
F
R
T
A
M
T
A
G
F
Y
E
D
E
D
W
---
Q
S
R
M
L
E
K
I
P
Q
R
R
F
G
K
E
S
D
I
G
G
V
A
V
F
L
C
S
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
Y
L
A
-
10
PsiBlast_PDB
74.51
42%
-41
- C1 -
4J2H
7
?
A:
[8-255]
-------
F
D
L
S
G
R
R
A
L
V
T
G
A
S
R
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
T
A
-
R
T
V
E
G
L
A
E
T
R
A
L
I
E
K
T
G
R
R
A
V
-
A
L
A
Q
D
V
R
D
----
V
E
A
C
A
S
V
T
R
A
A
A
E
G
-
L
-
G
-
G
--
L
D
I
L
V
N
N
A
G
F
E
N
V
R
P
S
F
D
V
D
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
I
M
A
D
A
-
N
G
-
G
-
A
I
V
N
L
C
S
L
T
S
Y
V
G
I
--
P
T
A
V
P
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
W
A
A
H
N
I
R
V
N
A
I
A
P
G
Y
F
R
T
A
M
T
A
G
F
Y
E
D
E
D
W
---
Q
S
R
M
L
E
K
I
P
Q
R
R
F
G
K
E
S
D
I
G
G
V
A
V
F
L
C
S
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
Y
L
A
-
31
PsiBlast_CBE
74.41
41%
-24
- C1 -
4G81
3
?
B:
[5-253]
-------
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
-
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
-
G
V
A
F
D
V
T
D
----
E
L
A
---
I
E
A
A
F
S
K
L
D
A
-
E
-
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
-
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
--
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
F
---
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
-
115
HHSearch
74.27
41%
-23
- C1 -
4G81
2
?
D:
[3-253]
-----
A
L
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
-
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
-
G
V
A
F
D
V
T
D
----
E
L
A
---
I
E
A
A
F
S
K
L
-
D
-
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
G
-
G
-
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
--
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
F
---
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
-
11
PsiBlast_PDB
73.65
41%
-23
- C1 -
4G81
2
?
D:
[5-253]
-------
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
-
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
-
G
V
A
F
D
V
T
D
----
E
L
A
---
I
E
A
A
F
S
K
L
D
A
-
E
-
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
-
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
--
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
F
---
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
-
88
PsiBlast_CBE
70.17
34%
-63
- C1 -
2EKQ
4
?
A:
[3-238]
------------
R
K
A
L
V
T
G
G
S
R
G
I
G
R
A
I
A
E
A
L
V
A
R
G
Y
R
V
A
I
A
S
-
R
N
-
P
-----
E
E
A
A
Q
S
L
G
A
V
P
L
-
P
T
D
L
E
K
D
D
----
P
K
G
---
L
V
K
R
A
L
E
A
-
L
-
G
-
G
--
L
H
V
L
V
H
A
A
A
V
N
V
R
K
P
A
L
E
L
S
Y
E
E
W
R
R
V
L
Y
L
H
L
D
V
A
F
L
L
A
Q
A
A
A
P
H
M
A
E
A
-
G
W
-
G
-
R
V
L
F
I
G
S
V
T
T
F
T
A
G
GP
V
P
I
P
A
Y
T
T
A
K
T
A
L
L
G
L
T
R
A
L
A
K
E
W
A
R
L
G
I
R
V
N
L
L
C
P
G
Y
V
E
T
E
F
T
L
P
L
R
Q
N
P
E
L
---
Y
E
P
I
T
A
R
I
P
M
G
R
W
A
R
P
E
E
I
A
R
V
A
A
V
L
C
G
D
E
A
E
Y
L
T
G
Q
A
V
A
V
D
G
G
F
L
A
-
6
PsiBlast_PDB
69.49
42%
-33
- C1 -
3O03
3
?
A:
[28-283]
-----
D
Q
F
S
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
-
I
N
-
Q
E
L
V
D
R
G
M
A
A
Y
K
A
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
----
E
D
G
---
I
Q
A
M
V
A
Q
I
E
S
-
E
-
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
M
I
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
-
G
H
-
G
-
K
I
I
N
I
C
S
M
M
S
E
L
G
R
--
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
---------H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
-
58
PsiBlast_CBE
69.01
38%
-42
- C1 -
4I08
9
FABG_VIBCH
B:
[8-248]
-------
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
----
T
S
E
S
G
A
Q
A
I
S
D
Y
L
G
D
N
G
K
-
G
M
A
L
N
V
T
N
----
P
E
S
---
I
E
A
V
L
K
A
I
-
T
D
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
Q
-
G
-
R
I
I
N
V
G
S
V
V
G
T
M
G
N
--
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
--
T
K
A
L
N
D
E
Q
R
-----
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
---
62
PsiBlast_CBE
67.89
38%
-41
- C1 -
3RRO
13
FABG_VIBCH
B:
[8-248]
-------
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
----
T
S
E
S
G
A
Q
A
I
S
D
Y
L
G
D
N
G
K
-
G
M
A
L
N
V
T
N
----
P
E
S
---
I
E
A
V
L
K
A
I
-
T
D
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
Q
-
G
-
R
I
I
N
V
G
S
V
V
G
T
M
G
N
--
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
-----
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
---
63
PsiBlast_CBE
67.41
38%
-41
- C1 -
3RRO
11
FABG_VIBCH
A:
[8-248]
-------
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
----
T
S
E
S
G
A
Q
A
I
S
D
Y
L
G
D
N
G
K
-
G
M
A
L
N
V
T
N
----
P
E
S
---
I
E
A
V
L
K
A
I
-
T
D
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
Q
-
G
-
R
I
I
N
V
G
S
V
V
G
T
M
G
N
--
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
-----
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
---