@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37730: (2016-08-02 )
MNLTDKTVLITGGASGIGYAAVQAFLNQQANVVVADIDEAQGEAMIRKENNDRLHFVHTDITDEPACQNAIRSAVDKFGGLDVLINNAGIEIVAPIHEMELSNWNKVLNVNLTGMFLMSKHALKYMLKSGKGNIINTCSVGGVVAWPDIPAYNASKGGVLQLTRSMAVDYAKHNIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ
Atome Classification :
(47 SA)
.........10........20........30...----.....40........50....--....60........70........80........90....----....100.......110.......120.......-130.-.......140..--.....150.......160.......170-........180.......190..---..--..---.---200.......210.-......220.......230.......240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNLT
D
K
T
V
L
I
TGGASG
I
G
Y
A
A
V
Q
A
F
L
NQQA
N
V
V
V
----
A
DIDEAQG
E
A
M
I
RKENND
R
L
H
--
F
V
HTDITD
E
P
A
C
Q
N
A
I
R
S
A
V
D
KFGG
L
D
V
L
I
NNA
G
I
E
I
V
A
P
----
I
H
E
MELSNW
N
K
V
L
N
V
N
L
T
G
M
F
L
M
S
K
H
A
L
K
Y
M
L
K
S-G-KG-
N
I
I
N
TCSVG
G
V
V
--AWPDIPAYNASKG
G
V
L
Q
L
T
R
S
M
A
V
D
Y
A--KH
N
I
R
V
N
C
VCPGIIDTPLN
E
K
S
F---LE--NN---E---G
T
L
E
E
I
K
K
E
K
AKVN-
P
L
LRLG
K
P
E
E
I
A
N
V
M
L
F
L
A
S
D
L
S
S
Y
MTG
S
A
I
TADGGYTAQ
37
PsiBlast_CBE
85.49
40%
-109
- C1 -
4NBU
1
?
C:
[11-247]
--
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
----
A
D
F
N
E
A
A
G
K
E
A
V
--
E
A
N
P
G
V
V
--
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
----
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
--
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
---
A
E
--
V
P
---
E
---
K
V
I
E
---
K
M
K
A
Q
V
--
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
----
70
PsiBlast_CBE
84.60
37%
-107
- C1 -
1NFQ
2
HSD_MYCTU
A:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
69
PsiBlast_CBE
84.05
37%
-107
- C1 -
1NFQ
2
HSD_MYCTU
B:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
122
HHSearch
84.02
43%
-124
* C1 *
4NI5
1
?
A:
[10-254]
-
R
F
K
D
K
V
V
I
V
T
G
G
A
S
G
I
G
E
A
T
A
R
A
F
I
R
E
G
A
K
V
V
I
----
A
D
F
S
D
--------------
A
L
--
F
I
K
T
D
V
A
D
T
R
A
V
Q
A
L
I
A
R
T
V
E
N
Y
G
R
L
D
I
M
F
A
N
A
G
I
A
A
D
A
P
----
I
D
E
L
D
E
A
A
W
Q
K
T
I
D
I
N
L
T
G
V
Y
L
C
D
K
Y
A
I
D
Q
M
R
S
Q
-
G
-
G
G
-
V
I
V
N
C
G
S
I
H
S
H
V
--
G
K
S
G
V
T
A
Y
A
A
A
K
G
G
V
K
L
L
T
Q
T
L
A
I
D
Y
G
--
P
Q
N
I
R
V
N
A
V
C
P
G
Y
I
D
T
------
P
---
D
D
--
K
--------------
K
Q
A
L
V
A
L
H
-
P
M
G
R
L
G
R
A
E
E
V
A
N
A
V
L
F
L
A
S
D
E
A
S
F
V
N
G
A
S
L
L
V
D
G
G
Y
T
A
Q
67
PsiBlast_CBE
83.94
37%
-107
- C1 -
1NFQ
2
HSD_MYCTU
D:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
38
PsiBlast_CBE
83.78
40%
-108
- C1 -
4NBU
2
?
B:
[11-247]
--
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
----
A
D
F
N
E
A
A
G
K
E
A
V
--
E
A
N
P
G
V
V
--
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
----
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
--
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
---
A
E
--
V
P
---
E
---
K
V
I
E
---
K
M
K
A
Q
V
--
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
----
77
PsiBlast_CBE
83.35
34%
-98
- C1 -
2DTD
2
?
B:
[5-249]
-
D
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
----
L
S
I
H
D
P
-
G
E
A
--------
K
Y
D
--
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
E
S
Y
G
K
----
I
E
S
M
S
M
G
E
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
-
D
P
-
S
I
V
N
I
S
S
V
Q
A
S
I
--
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
--
P
L
-
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E--
L
E
VG
S
D
---
P
---
M
R
I
E
K
K
I
S
E
W
G
H
E
H
-
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
71
PsiBlast_CBE
83.32
37%
-105
- C1 -
1NFF
1
HSD_MYCTU
B:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
73
PsiBlast_CBE
82.61
34%
-95
- C1 -
2DTX
2
?
B:
[5-249]
-
D
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
----
L
S
I
H
D
P
-
G
E
A
--------
K
Y
D
--
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
E
S
Y
G
K
----
I
E
S
M
S
M
G
E
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
-
D
P
-
S
I
V
N
I
S
S
V
Q
A
S
I
--
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
--
P
L
-
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E--
L
E
VG
S
D
---
P
---
M
R
I
E
K
K
I
S
E
W
G
H
E
H
-
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
68
PsiBlast_CBE
82.61
37%
-106
- C1 -
1NFQ
2
HSD_MYCTU
C:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
113
HHSearch
82.54
35%
-73
- C1 -
3WDS
4
?
A:
[9-262]
-
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
----
A
D
L
D
V
M
A
A
Q
A
V
V
A
-
G
L
E
N
G
G
F
--
A
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
R
P
----
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
-
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
--
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
---
I
W
--
E
A
E
L
R
G
---
M
T
P
E
A
V
R
A
E
Y
V
S
L
T
-
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
M
-
72
PsiBlast_CBE
82.49
37%
-107
- C1 -
1NFF
1
HSD_MYCTU
A:
[4-240]
-
R
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
----
G
D
I
L
D
E
E
G
K
A
M
A
A
E
L
A
D
-
A
A
R
--
Y
V
H
L
D
V
T
Q
P
A
Q
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
L
N
I
G
T
----
I
E
D
Y
A
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
-
G
-
R
G
-
S
I
I
N
I
S
S
I
E
G
L
A
--
G
T
V
A
C
H
G
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
--
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
M
T
D
W
-------------------
V
P
E
D
I
F
Q
-----
T
-
A
L
G
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
-
48
PsiBlast_CBE
82.19
35%
-69
- C1 -
3AK4
1
?
D:
[8-259]
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
----
A
D
L
D
V
M
A
A
Q
A
V
V
A
G
L
E
N
G
G
F
A
---
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
R
P
----
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
-
N
T
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
--
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
---
I
W
--
E
A
---
E
LRG
M
T
P
E
A
V
R
A
E
Y
V
S
L
T
-
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
----
36
PsiBlast_CBE
82.12
40%
-109
- C1 -
4NBU
2
?
D:
[11-247]
--
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
----
A
D
F
N
E
A
A
G
K
E
A
V
--
E
A
N
P
G
V
V
--
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
----
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
--
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
---
A
E
--
V
P
---
E
---
K
V
I
E
---
K
M
K
A
Q
V
--
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
----
45
PsiBlast_CBE
82.11
35%
-72
- C1 -
3WDS
2
?
D:
[8-259]
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
----
A
D
L
D
V
M
A
A
Q
A
V
V
A
G
L
E
N
G
G
F
A
---
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
R
P
----
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
-
N
T
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
--
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
---
I
W
--
E
A
---
E
LRG
M
T
P
E
A
V
R
A
E
Y
V
S
L
T
-
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
----
15
PsiBlast_PDB
81.87
35%
-66
- C1 -
3WDS
4
?
A:
[8-259]
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
----
A
D
L
D
V
M
A
A
Q
A
V
V
A
G
L
E
N
G
G
F
A
---
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
R
P
----
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
-
N
T
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
--
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
---
I
W
--
E
A
---
E
L
R
G
M
T
P
E
A
V
R
A
E
Y
V
S
L
T
-
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
----
7
PsiBlast_PDB
81.77
40%
-87
- C1 -
3VTZ
-
?
A:
[4-248]
--
F
T
D
K
V
A
I
V
T
G
G
S
S
G
I
G
L
A
V
V
D
A
L
V
R
Y
G
A
K
V
V
S
----
V
S
L
D
E
---------
D
V
N
V
S
D
H
--
F
-
K
I
D
V
T
N
E
E
E
V
K
E
A
V
E
K
T
T
K
K
Y
G
R
I
D
I
L
V
N
N
A
G
I
E
Q
Y
S
P
----
L
H
L
T
P
T
E
I
W
R
R
I
I
D
V
N
V
N
G
S
Y
L
M
A
K
Y
T
I
P
V
M
L
A
I
-
G
-
H
G
-
S
I
I
N
I
A
S
V
Q
S
Y
A
--
A
T
K
N
A
A
A
Y
V
T
S
K
H
A
L
L
G
L
T
R
S
V
A
I
D
Y
A
--
P
-
K
I
R
C
N
A
V
C
P
G
T
I
M
T
P
M
V
I
K
A
A
K
M
E
V
G
--
E
D
---
E
---
N
A
V
E
R
K
I
E
E
W
G
R
Q
H
-
P
M
G
R
I
G
R
P
E
E
V
A
E
V
V
A
F
L
A
S
D
R
S
S
F
I
T
G
A
C
L
T
V
D
G
G
L
L
S
K
47
PsiBlast_CBE
81.42
35%
-68
- C1 -
3WDS
3
?
B:
[8-259]
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
----
A
D
L
D
V
M
A
A
Q
A
V
V
A
G
L
E
N
G
G
F
A
---
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
R
P
----
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
-
N
T
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
--
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
---
I
W
--
E
A
---
E
LRG
M
T
P
E
A
V
R
A
E
Y
V
S
L
T
-
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
----
74
PsiBlast_CBE
81.40
34%
-96
- C1 -
2DTX
2
?
A:
[5-249]
-
D
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
----
L
S
I
H
D
P
-
G
E
A
--------
K
Y
D
--
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
E
S
Y
G
K
----
I
E
S
M
S
M
G
E
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
-
D
P
-
S
I
V
N
I
S
S
V
Q
A
S
I
--
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
--
P
L
-
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E
--
L
E
VG
S
D
---
P
---
M
R
I
E
K
K
I
S
E
W
G
H
E
H
-
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
11
PsiBlast_PDB
81.40
40%
-109
- C1 -
4NBU
1
?
A:
[11-247]
--
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
----
A
D
F
N
E
A
A
G
K
E
A
V
--
E
A
N
P
G
V
V
--
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
----
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
--
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
---
A
E
--
V
P
---
E
---
K
V
I
E
---
K
M
K
A
Q
V
--
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
----
75
PsiBlast_CBE
80.37
34%
-96
- C1 -
2DTE
1
?
B:
[5-249]
-
D
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
----
L
S
I
H
D
P
-
G
E
A
--------
K
Y
D
--
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
E
S
Y
G
K
----
I
E
S
M
S
M
G
E
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
-
D
P
-
S
I
V
N
I
S
S
V
Q
A
S
I
--
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
--
P
L
-
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E--
L
E
VG
S
D
---
P
---
M
R
I
E
K
K
I
S
E
W
G
H
E
H
-
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
95
PsiBlast_CBE
80.03
36%
-88
- C1 -
2HSD
1
HSD_STREX
A:
[2-242]
-
D
L
S
G
K
T
V
I
I
T
G
G
A
R
G
L
G
A
E
A
A
R
Q
A
V
A
A
G
A
R
V
V
L
----
A
D
V
L
D
E
E
G
A
A
T
A
R
-
E
L
G
D
A
A
R
--
Y
Q
H
L
D
V
T
I
E
E
D
W
Q
R
V
V
A
Y
A
R
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
S
T
G
M
F
----
L
E
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
M
K
T
V
I
P
A
M
K
D
A
-
G
-
G
G
-
S
I
V
N
I
S
S
A
A
G
L
M
--
G
L
A
L
T
S
S
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
--
T
D
R
I
R
V
N
S
V
H
P
G
M
T
Y
T
P
M
T
A
E
T
G
---
I
R
--
Q
G
---
E
---
G
N
Y
P
N
--------
T
-
P
M
G
R
V
G
E
P
G
E
I
A
G
A
V
V
K
L
L
S
D
T
S
S
Y
V
T
G
A
E
L
A
V
D
G
G
W
T
--
76
PsiBlast_CBE
79.92
34%
-96
- C1 -
2DTE
1
?
A:
[5-249]
-
D
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
----
L
S
I
H
D
P
-
G
E
A
--------
K
Y
D
--
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
E
S
Y
G
K
----
I
E
S
M
S
M
G
E
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
-
D
P
-
S
I
V
N
I
S
S
V
Q
A
S
I
--
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
--
P
L
-
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E
--
L
E
VG
S
D
---
P
---
M
R
I
E
K
K
I
S
E
W
G
H
E
H
-
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
30
PsiBlast_CBE
78.73
40%
-22
- C1 -
1GEE
1
DHG_BACME
F:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
32
PsiBlast_CBE
78.35
40%
-21
- C1 -
1GEE
1
DHG_BACME
B:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
93
PsiBlast_CBE
78.24
36%
-86
- C1 -
2HSD
1
HSD_STREX
C:
[2-242]
-
D
L
S
G
K
T
V
I
I
T
G
G
A
R
G
L
G
A
E
A
A
R
Q
A
V
A
A
G
A
R
V
V
L
----
A
D
V
L
D
E
E
G
A
A
T
A
R
-
E
L
G
D
A
A
R
--
Y
Q
H
L
D
V
T
I
E
E
D
W
Q
R
V
V
A
Y
A
R
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
S
T
G
M
F
----
L
E
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
M
K
T
V
I
P
A
M
K
D
A
-
G
-
G
G
-
S
I
V
N
I
S
S
A
A
G
L
M
--
G
L
A
L
T
S
S
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
--
T
D
R
I
R
V
N
S
V
H
P
G
M
T
Y
T
P
M
T
A
E
T
G
---
I
R
--
Q
G
---
E
---
G
N
Y
P
N
--------
T
-
P
M
G
R
V
G
E
P
G
E
I
A
G
A
V
V
K
L
L
S
D
T
S
S
Y
V
T
G
A
E
L
A
V
D
G
G
W
T
--
94
PsiBlast_CBE
78.07
36%
-89
- C1 -
2HSD
1
HSD_STREX
B:
[2-242]
-
D
L
S
G
K
T
V
I
I
T
G
G
A
R
G
L
G
A
E
A
A
R
Q
A
V
A
A
G
A
R
V
V
L
----
A
D
V
L
D
E
E
G
A
A
T
A
R
-
E
L
G
D
A
A
R
--
Y
Q
H
L
D
V
T
I
E
E
D
W
Q
R
V
V
A
Y
A
R
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
S
T
G
M
F
----
L
E
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
M
K
T
V
I
P
A
M
K
D
A
-
G
-
G
G
-
S
I
V
N
I
S
S
A
A
G
L
M
--
G
L
A
L
T
S
S
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
--
T
D
R
I
R
V
N
S
V
H
P
G
M
T
Y
T
P
M
T
A
E
T
G
---
I
R
--
Q
G
---
E
---
G
N
Y
P
N
--------
T
-
P
M
G
R
V
G
E
P
G
E
I
A
G
A
V
V
K
L
L
S
D
T
S
S
Y
V
T
G
A
E
L
A
V
D
G
G
W
T
--
31
PsiBlast_CBE
77.84
40%
-21
- C1 -
1GEE
1
DHG_BACME
E:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
33
PsiBlast_CBE
77.82
40%
-20
- C1 -
1GCO
1
DHG_BACME
F:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
35
PsiBlast_CBE
77.75
40%
-20
- C1 -
1GCO
1
DHG_BACME
B:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
41
PsiBlast_CBE
77.67
40%
-22
- C1 -
1G6K
1
DHG_BACME
B:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
A
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
9
PsiBlast_PDB
77.54
40%
-21
- C1 -
1GEE
1
DHG_BACME
A:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
10
PsiBlast_PDB
77.42
40%
-20
- C1 -
1GCO
1
DHG_BACME
A:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
34
PsiBlast_CBE
77.10
40%
-20
- C1 -
1GCO
1
DHG_BACME
E:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
27
PsiBlast_CBE
76.17
40%
-23
- C1 -
1RWB
1
DHG_BACME
F:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
12
PsiBlast_PDB
76.01
40%
-21
- C1 -
1G6K
1
DHG_BACME
A:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
A
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
8
PsiBlast_PDB
75.83
40%
-21
- C1 -
1RWB
1
DHG_BACME
A:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
28
PsiBlast_CBE
75.04
40%
-24
- C1 -
1RWB
1
DHG_BACME
E:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
29
PsiBlast_CBE
74.56
40%
-21
- C1 -
1RWB
1
DHG_BACME
B:
[4-251]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
NYR-
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
--
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
V
S
----
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
--
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
---
A
D
--------------
P
E
Q
R
A
D
V
E
S
M
I
-
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
--
92
PsiBlast_CBE
74.18
36%
-87
- C1 -
2HSD
1
HSD_STREX
D:
[2-242]
-
D
L
S
G
K
T
V
I
I
T
G
G
A
R
G
L
G
A
E
A
A
R
Q
A
V
A
A
G
A
R
V
V
L
----
A
D
V
L
D
E
E
G
A
A
T
A
R
-
E
L
G
D
A
A
R
--
Y
Q
H
L
D
V
T
I
E
E
D
W
Q
R
V
V
A
Y
A
R
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
S
T
G
M
F
----
L
E
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
M
K
T
V
I
P
A
M
K
D
A
-
G
-
G
G
-
S
I
V
N
I
S
S
A
A
G
L
M
--
G
L
A
L
T
S
S
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
--
T
D
R
I
R
V
N
S
V
H
P
G
M
T
Y
T
P
M
T
A
E
T
G
---
I
R
--
Q
G
---
E
---
G
N
Y
P
N
--------
T
-
P
M
G
R
V
G
E
P
G
E
I
A
G
A
V
V
K
L
L
S
D
T
S
S
Y
V
T
G
A
E
L
A
V
D
G
G
W
T
--
43
PsiBlast_CBE
73.22
39%
-29
- C1 -
4WEC
5
?
C:
[27-272]
-
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
----
G
D
I
D
P
T
T
G
K
A
A
-----
A
D
E
L
E
GL
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
--
P
P
EDDL
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
GS
A
T
S
Q
I
-
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
--
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
L
Q
E
L
F
---
A
K
--
D
P
---
E
---------
R
A
A
R
R
L
V
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
-
44
PsiBlast_CBE
72.52
39%
-28
- C1 -
4WEC
5
?
B:
[27-272]
-
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
----
G
D
I
D
P
T
T
G
K
A
A
-----
A
D
E
L
E
G
L
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
--
P
P
EDDL
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
GS
A
T
S
Q
I
-
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
--
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
L
Q
E
L
F
---
A
K
--
D
P
---
E
---------
R
A
A
R
R
L
V
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
-
13
PsiBlast_PDB
72.16
39%
-25
- C1 -
4WEC
5
?
A:
[27-272]
-
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
----
G
D
I
D
P
T
T
G
K
A
A
-----
A
D
E
L
E
G
L
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
--
P
P
EDDL
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
GS
A
T
S
Q
I
-
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
--
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
L
Q
E
L
F
---
A
K
--
D
P
---
E
---------
R
A
A
R
R
L
V
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
-
42
PsiBlast_CBE
70.74
39%
-29
- C1 -
4WEC
5
?
D:
[27-272]
-
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
----
G
D
I
D
P
T
T
G
K
A
A
-----
A
D
E
L
E
GL
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
--
P
P
EDDL
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
GS
A
T
S
Q
I
-
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
--
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
L
Q
E
L
F
---
A
K
--
D
P
---
E
---------
R
A
A
R
R
L
V
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
-
91
PsiBlast_CBE
69.72
35%
-18
- C1 -
4RF2
2
?
A:
[24-272]
-
R
L
K
G
K
V
A
I
V
T
G
G
T
L
G
I
G
L
A
I
A
D
K
F
V
E
E
G
A
K
V
V
I
T
G
RH
A
D
V
G
E
K
A
A
K
S
I
---
G
G
T
D
V
I
R
--
F
V
Q
H
D
A
S
D
E
A
G
W
T
K
L
F
D
T
T
E
E
A
F
G
P
V
T
T
V
V
N
N
A
G
I
A
V
S
K
S
----
V
E
D
T
T
T
E
E
W
R
K
L
L
S
V
N
L
D
G
V
F
F
G
T
R
L
G
I
Q
R
M
K
N
K
-
G
-
L
G
A
S
I
I
N
M
S
S
I
E
G
F
V
--
G
D
P
T
L
G
A
Y
N
A
S
K
G
A
V
R
I
M
S
K
S
A
A
L
D
C
A
L
K
D
Y
D
V
R
V
N
T
V
H
P
G
Y
I
K
T
P
L
--------
V
D
--
D
L
---
E
---
G
A
-
E
E
M
M
S
Q
R
T
K
-
T
-
P
M
G
H
I
G
E
P
N
D
I
A
W
I
C
V
Y
L
A
S
D
E
S
K
F
A
T
G
A
E
F
V
V
D
G
G
Y
T
A
Q
90
PsiBlast_CBE
68.94
35%
-19
- C1 -
4RF2
1
?
B:
[24-272]
-
R
L
K
G
K
V
A
I
V
T
G
G
T
L
G
I
G
L
A
I
A
D
K
F
V
E
E
G
A
K
V
V
I
TGRH
A
D
V
G
E
K
A
A
K
S
I
---
G
G
T
D
V
I
R
--
F
V
Q
H
D
A
S
D
E
A
G
W
T
K
L
F
D
T
T
E
E
A
F
G
P
V
T
T
V
V
N
N
A
G
I
A
V
S
K
S
----
V
E
D
T
T
T
E
E
W
R
K
L
L
S
V
N
L
D
G
V
F
F
G
T
R
L
G
I
Q
R
M
K
N
K
-
G
-
L
G
A
S
I
I
N
M
S
S
I
E
G
F
V
--
G
D
P
T
L
G
A
Y
N
A
S
K
G
A
V
R
I
M
S
K
S
A
A
L
D
C
A
LK
D
Y
D
V
R
V
N
T
V
H
P
G
Y
I
K
T
P
L
--------
V
D
--
D
L
---
E
---
G
A
-
E
E
M
M
S
Q
R
T
K
-
T
-
P
M
G
H
I
G
E
P
N
D
I
A
W
I
C
V
Y
L
A
S
D
E
S
K
F
A
T
G
A
E
F
V
V
D
G
G
Y
T
A
Q
108
HHSearch
66.32
30%
-126
- C1 -
3GED
4
?
A:
[2-230]
----
N
R
G
V
I
V
T
G
G
G
H
G
I
G
K
Q
I
C
L
D
F
L
E
A
G
D
K
V
C
F
----
I
D
I
D
E
K
R
S
A
D
F
A
K
-
E
-
R
P
N
L
F
--
Y
F
H
G
D
V
A
D
P
L
T
L
K
K
F
V
E
Y
A
M
E
K
L
Q
R
I
D
V
L
V
N
N
A
C
R
G
S
K
G
I
----
L
S
S
L
L
Y
E
E
F
D
Y
I
L
S
V
G
L
K
A
P
Y
E
L
S
R
L
C
R
D
E
L
I
K
--
N
-
K
G
-
R
I
I
N
I
A
S
T
R
A
F
Q
--
S
E
P
D
S
E
A
Y
A
S
A
K
G
G
I
V
A
L
T
H
A
L
A
M
S
L
G
--
P
-
D
V
L
V
N
C
I
A
P
G
W
I
N
V
T
---
E
F
T
---
Q
E
--------------------
D
C
A
A
I
-
P
A
G
K
V
G
T
P
K
D
I
S
N
M
V
L
F
L
C
Q
Q
--
D
F
I
T
G
E
T
I
I
V
D
G
G
M
S
--