@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40250: (2016-08-07 )
MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVNRKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGDIVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYADFQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAHSAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDCVGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIRFGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFDKGAAKKFVIDPHGTLK
Atome Classification :
(25 SA)
.........10.......-.-20........30........40........50--........60...-...------..70-..---------......80........90........100.......110.......120.....----.---.130.-------.-------------------..---------------.--------------..140-...---------..----....150.........--160.......170...----...----.180.......190..-.-....200.......-210.......220.......230.......240....-...250...-....260...--....---270.......280--...--....---.290-.........300..-.-....310.......320.......330.......340......-.--350-.--.--.......360.....-..370...-....380.......390..-.....400......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGG
M
A
LTGN
K
A
V
V
Y
KGK
G
-
T
-
V
A
V
EDIGYPE
L
I
L
RDGPGVPKANVNRKCEH
G
V
--
I
L
K
V
I
TTNICGSD-QHM------VRGR-TT---------APE
G
L
V
LG
H
E
I
T
G
E
V
I
ETGRD
V
E
F
IKKG
D
I
V
SVPFNIACG
R
C
V
M
CKTQK
T
H
V
C
L
----N---VNPDR-------P-------------------GS---------------A--------------Y
G
Y
---
V
D
M---------GG----WVGGQ--S
E
Y
V
M
V
PYA--
D
F
Q
L
L
V
FP
D
K
E
Q
A
L
E
K
----
I
L
D
----
L
T
M
L
S
D
IFPTGFHG
A
Y
-
T
-AGVQTG
S
T
V
Y
I
AGA-GPV
G
L
A
A
A
H
S
A
QLLG
A
S
T
V
I
V
GDL
N
E
D
R
L
A
Q
A
R
SFGC-ETVN
V
Q
K
H
D
-
R
L
G
E
Q
I
E
Q
I
L--GEPT---
V
D
A
A
V
D
C
V
G
FEA---SGH--GNQG---E
A
---
P
A
A
V
L
N
S
I
M
D
V
T
QV-G-GSLGI
P
G
L
Y
VTEDPGAKDADAKTG
S
L
K
I
R
F
G
LGW
A
K
A
H
T
F
VTG-Q--T---P--A--MTY
N
R
N
L
M
K
A
I
LS
G
R
-
A
Q
I
A
K
AV
N
-
A
T
V
I
SLDDAPKGYS
D
F
DKG-AA
K
K
F
V
IDPHGTLK-
23
PsiBlast_CBE
98.15
66%
-83
- C1 -
4JLW
6
?
B:
[3-397]
-------
G
N
R
G
V
V
Y
L
G
P
G
-
K
-
V
E
V
Q
N
I
P
Y
P
K
M
--
Q
D
P
Q
G
-------
R
Q
I
D
H
G
V
--
I
L
R
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
P
E
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
G
----
W
V
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
S
G
SQQ
E
A
---
P
A
T
V
L
N
S
L
M
G
I
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
H
G
A
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
-
I
K
I
A
D
I
V
G
-
V
E
V
I
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-
22
PsiBlast_CBE
98.07
66%
-84
- C1 -
4JLW
6
?
C:
[3-397]
-------
G
N
R
G
V
V
Y
L
G
P
G
-
K
-
V
E
V
Q
N
I
P
Y
P
K
M
--
Q
D
P
Q
G
-------
R
Q
I
D
H
G
V
--
I
L
R
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
P
E
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
G
----
W
V
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
S
G
SQQ
E
A
---
P
A
T
V
L
N
S
L
M
G
I
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
H
G
A
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
-
I
K
I
A
D
I
V
G
-
V
E
V
I
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-
21
PsiBlast_CBE
97.91
66%
-83
- C1 -
4JLW
5
?
D:
[3-397]
-------
G
N
R
G
V
V
Y
L
G
P
G
-
K
-
V
E
V
Q
N
I
P
Y
P
K
M
--
Q
D
P
Q
G
-------
R
Q
I
D
H
G
V
--
I
L
R
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
P
E
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
G
----
W
V
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
S
G
SQQ
E
A
---
P
A
T
V
L
N
S
L
M
G
I
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
H
G
A
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
-
I
K
I
A
D
I
V
G
-
V
E
V
I
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-
73
Fugue
97.58
67%
-80
- C1 -
1KOL
4
FADH_PSEPU
A:
[2-397]
-------
G
N
R
G
V
V
Y
L
G
S
G
-
K
-
V
E
V
Q
K
I
D
Y
P
K
M
Q
D
P
R
G
K
---------
K
I
E
H
G
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
D
----
W
T
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
E
G
---
A
K
H
EA
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
I
G
S
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
-
I
N
I
A
E
V
V
G
-
V
Q
V
I
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
K
T
F
S
A
24
PsiBlast_CBE
97.49
66%
-80
- C1 -
1KOL
4
FADH_PSEPU
B:
[2-395]
-------
G
N
R
G
V
V
Y
L
G
S
G
-
K
-
V
E
V
Q
K
I
D
Y
P
K
M
--
Q
D
P
R
G
-------
K
K
I
E
H
G
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
D
----
W
T
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
E
G
AKH
E
A
---
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
I
G
S
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
-
I
N
I
A
E
V
V
G
-
V
Q
V
I
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
K
T
F
--
1
PsiBlast_PDB
97.40
66%
-82
* C1 *
4JLW
5
?
A:
[3-397]
-------
G
N
R
G
V
V
Y
L
G
P
G
-
K
-
V
E
V
Q
N
I
P
Y
P
K
M
--
Q
D
P
Q
G
-------
R
Q
I
D
H
G
V
--
I
L
R
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
P
E
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
G
----
W
V
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
S
G
S
Q
Q
E
A
---
P
A
T
V
L
N
S
L
M
G
I
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
H
G
A
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
-
I
K
I
A
D
I
V
G
-
V
E
V
I
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-
2
PsiBlast_PDB
96.28
66%
-77
- C1 -
1KOL
4
FADH_PSEPU
A:
[2-395]
-------
G
N
R
G
V
V
Y
L
G
S
G
-
K
-
V
E
V
Q
K
I
D
Y
P
K
M
--
Q
D
P
R
G
-------
K
K
I
E
H
G
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
D
----
W
T
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
K
----
I
R
D
----
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
-
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
---
R
G
H
--
G
H
E
G
A
K
H
E
A
---
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
I
G
S
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
-
I
N
I
A
E
V
V
G
-
V
Q
V
I
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
K
T
F
--
82
HHSearch
82.26
67%
-33
- C1 -
1KOL
4
FADH_PSEPU
A:
[2-394]
-------
G
N
R
G
V
V
Y
L
G
S
G
-
K
-
V
E
V
Q
K
I
D
Y
P
K
M
Q
D
------
P
R
G
K
---
K
I
E
H
G
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
M
------
V
R
G
R
-
T
T
---------
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
----
T
---
V
N
P
A
R
-------
A
-------------------
G
G
---------------
A
--------------
Y
G
Y
---
V
D
M
---------
G
D
----
W
T
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
DF
N
--
L
L
K
L
P
D
R
----
D
K
----
A
M
E
K
I
R
D
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
-
T
-
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
-
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
E
I
A
D
L
S
L
D
T
--
P
L
H
E
Q
I
A
A
L
L
--
G
E
P
E
---
V
D
C
A
V
D
A
V
G
F
E
A
R
G
H
G
H
E
--
G
A
K
H
---
E
A
---
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
-
G
K
I
G
I
P
G
L
Y
V
T
E
D
P
G
A
V
D
A
A
A
K
I
G
S
L
S
I
R
F
G
L
G
W
A
K
S
H
S
F
H
T
G
-
Q
--
T
---
P
--
V
--
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
-
I
N
I
A
E
V
V
G
V
Q
V
I
S
-
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
-
V
P
K
K
F
V
I
D
P
H
K
T
---
3
PsiBlast_PDB
79.57
54%
-24
- C1 -
2DPH
4
FDM_PSEPU
A:
[2-396]
-------
G
N
K
S
V
V
Y
H
G
T
R
-
D
-
L
R
V
E
T
V
P
Y
P
K
L
----------
E
H
N
N
R
K
L
E
H
A
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
I
------
Y
R
G
R
-
F
I
---------
V
P
K
G
H
V
L
G
H
E
I
T
G
E
V
V
E
K
G
S
D
V
E
L
M
D
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
N
C
K
E
A
R
S
D
V
C
E
----
N
NL-
V
N
P
D
A
-------
D
-------------------
L
G
---------------
A
--------------
F
G
F
----
D
L
---------
K
G
----
W
S
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
Y
M
L
L
K
F
G
D
K
E
Q
A
M
E
K
----
I
K
D
----
L
T
L
I
S
D
I
L
P
T
G
F
H
G
C
V
-
S
-
A
G
V
K
P
G
S
H
V
Y
I
A
G
A
-
G
P
V
G
R
C
A
A
A
G
A
R
L
L
G
A
A
C
V
I
V
G
D
Q
N
P
E
R
L
K
L
L
S
D
A
G
F
-
E
T
I
D
L
R
N
S
A
-
P
L
R
D
Q
I
D
Q
I
L
--
G
K
P
E
---
V
D
C
G
V
D
A
V
G
F
E
A
---
H
G
L
--
G
D
E
A
NT-
E
T
---
P
N
G
A
L
N
S
L
F
D
V
V
R
A
-
G
-
G
A
I
G
I
P
G
I
Y
V
G
S
D
P
D
P
V
N
K
D
A
G
S
G
R
L
H
L
D
F
G
K
M
W
T
K
S
I
R
I
M
T
G
-
M
--
A
---
P
--
V
--
T
N
Y
N
R
H
L
T
E
A
I
L
W
D
Q
M
P
Y
L
S
K
V
M
N
-
I
E
V
I
T
L
D
Q
A
P
D
G
Y
A
K
F
D
K
G
-
S
P
A
K
F
V
I
D
P
H
G
M
L
K
-
25
PsiBlast_CBE
78.79
54%
-25
- C1 -
2DPH
4
FDM_PSEPU
B:
[2-396]
-------
G
N
K
S
V
V
Y
H
G
T
R
-
D
-
L
R
V
E
T
V
P
Y
P
K
L
----------
E
H
N
N
R
K
L
E
H
A
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
I
------
Y
R
G
R
-
F
I
---------
V
P
K
G
H
V
L
G
H
E
I
T
G
E
V
V
E
K
G
S
D
V
E
L
M
D
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
N
C
K
E
A
R
S
D
V
C
E
----
N
NL-
V
N
P
D
A
-------
D
-------------------
L
G
---------------
A
--------------
F
G
F
----
D
L
---------
K
G
----
W
S
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
Y
M
L
L
K
F
G
D
K
E
Q
A
M
E
K
----
I
K
D
----
L
T
L
I
S
D
I
L
P
T
G
F
H
G
C
V
-
S
-
A
G
V
K
P
G
S
H
V
Y
I
A
G
A
-
G
P
V
G
R
C
A
A
A
G
A
R
L
L
G
A
A
C
V
I
V
G
D
Q
N
P
E
R
L
K
L
L
S
D
A
G
F
-
E
T
I
D
L
R
N
S
A
-
P
L
R
D
Q
I
D
Q
I
L
--
G
K
P
E
---
V
D
C
G
V
D
A
V
G
F
E
A
---
H
G
L
--
G
D
E
A
NT-
E
T
---
P
N
G
A
L
N
S
L
F
D
V
V
R
A
-
G
-
G
A
I
G
I
P
G
I
Y
V
G
S
D
P
D
P
V
N
K
D
A
G
S
G
R
L
H
L
D
F
G
K
M
W
T
K
S
I
R
I
M
T
G
-
M
--
A
---
P
--
V
--
T
N
Y
N
R
H
L
T
E
A
I
L
W
D
Q
M
P
Y
L
S
K
V
M
N
-
I
E
V
I
T
L
D
Q
A
P
D
G
Y
A
K
F
D
K
G
-
S
P
A
K
F
V
I
D
P
H
G
M
L
K
-
98
HHSearch
70.99
52%
-17
- C1 -
2DPH
4
FDM_PSEPU
A:
[2-395]
-------
G
N
K
S
V
V
Y
H
G
T
R
-
D
-
L
R
V
E
T
V
P
Y
P
K
L
E
----------
H
N
N
R
K
L
E
H
A
V
--
I
L
K
V
V
S
T
N
I
C
G
S
D
-
Q
H
I
------
Y
R
G
R
-
F
I
---------
V
P
K
G
H
V
L
G
H
E
I
T
G
E
V
V
E
K
G
S
D
V
E
L
M
D
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
N
C
K
E
A
R
S
D
V
C
E
----
N
---
N
L
V
N
P
DA-----
D
-------------------
L
G
---------------
A
--------------
F
G
F
---
D
-
L
---------
K
G
----
W
S
G
G
Q
--
A
E
Y
V
L
V
P
Y
A
--
D
Y
M
L
L
K
F
G
D
K
----
E
Q
A
M
E
K
I
K
D
----
L
T
L
I
S
D
I
L
P
T
G
F
H
G
C
V
-
S
-
A
G
V
K
P
G
S
H
V
Y
I
A
G
A
-
G
P
V
G
R
C
A
A
A
G
A
R
L
L
G
A
A
C
V
I
V
G
D
Q
N
P
E
R
L
K
L
L
S
D
A
G
F
-
E
T
I
D
L
R
N
S
A
-
P
L
R
D
Q
I
D
Q
I
L
--
G
K
P
E
---
V
D
C
G
V
D
A
V
G
F
E
A
---
H
G
L
GD
E
A
N
T
---
E
T
---
P
N
G
A
L
N
S
L
F
D
V
V
R
A
-
G
-
G
A
I
G
I
P
G
I
Y
V
G
S
D
P
D
P
V
N
K
D
A
G
S
G
R
L
H
L
D
F
G
K
M
W
T
K
S
I
R
I
M
T
G
-
M
--
A
PVT
N
--
Y
--
N
R
H
L
T
E
A
I
L
W
D
Q
M
P
Y
-
L
S
-
K
V
M
N
I
-
E
V
I
T
-
L
D
Q
A
P
D
G
Y
A
K
F
D
K
G
-
S
P
A
K
F
V
I
D
P
H
G
M
L
--
89
HHSearch
59.41
26%
-83
- C1 -
4EJ6
19
?
A:
[21-363]
-----
Q
S
M
M
K
A
V
R
L
E
S
V
G
-
N
-
I
S
V
R
N
V
G
I
P
E
P
G
----------------
P
D
D
L
--
L
V
K
V
E
A
C
G
I
C
G
T
D
-
R
H
L
------
L
H
G
E
-
F
P
---------
S
T
P
P
V
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
S
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
----
N
---
L
R
A
-------------------------------------------------------------
I
G
I
----------------
H
----
R
D
G
G
F
--
A
E
Y
V
L
V
P
R
K
--
Q
--
A
F
E
I
P
L
T
----
L
D
----
P
V
H
----
G
A
F
C
-
E
P
L
A
C
C
L
H
G
V
D
-
L
-
S
G
I
K
A
G
S
T
V
A
I
L
G
G
-
G
V
I
G
L
L
T
V
Q
L
A
R
L
A
G
A
T
T
V
I
L
S
T
R
Q
A
T
K
R
R
L
A
E
E
V
G
A
T
A
T
V
D
P
S
A
G
--
D
V
V
E
A
I
A
G
P
V
GL
V
P
G
G
---
V
D
V
V
I
E
C
A
G
V
A
-----------------------
E
T
V
K
Q
S
T
R
L
A
K
A
-
G
-
G
T
V
V
I
L
G
V
L
P
Q
G
E
-----------
K
V
E
I
E
P
F
D
I
L
F
R
E
L
R
V
L
G
S
-
F
--
I
------
N
--
P
F
V
H
R
R
A
A
D
L
V
A
T
G
A
-
I
E
I
D
R
M
I
S
-
R
R
I
S
-
L
D
E
A
P
D
V
I
S
N
P
A
A
A
-
G
E
V
K
V
L
V
I
P
S
-----
4
PsiBlast_PDB
57.40
29%
-40
- C1 -
4CPD
3
?
A:
[2-343]
---------
R
A
V
V
F
E
N
K
E
-
R
-
V
A
V
K
E
V
N
A
P
R
L
-----------------
Q
H
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
-
L
H
L
------
Y
H
G
K
-
I
P
---------
V
L
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
Q
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
------------
E
R
---------------------------
G
G
---------------
V
--------------
Y
G
Y
---
G
P
M
F--------
G
N
----
L
Q
G
A
Q
--
A
E
I
L
R
V
P
F
S
--
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
A
----
I
F
A
--------
G
D
I
L
S
T
A
Y
G
G
L
I
-
Q
-
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
-
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
-
I
P
I
N
A
E
Q
E
N
-----
P
V
R
R
V
R
--
S
E
-
T
---
N
D
E
G
P
D
L
V
-
L
E
A
---
V
G
G
---------------
A
A
T
L
S
L
A
L
E
M
V
R
P
-
G
-
G
R
V
S
A
V
G
--
V
D
N
A
P
----------
S
F
P
F
P
L
A
S
G
L
V
K
D
L
T
F
R
I
G
-
L
--
A
---
N
--
V
--
H
L
Y
I
D
A
V
L
A
L
L
A
S
G
R
-
L
Q
P
E
R
I
V
--
S
H
Y
L
P
L
E
E
A
P
R
G
Y
E
L
F
D
R
K
-
E
A
L
K
V
L
L
--------
87
HHSearch
47.60
25%
-40
- C1 -
1E3I
4
ADH4_MOUSE
A:
[4-367]
---
G
K
V
I
K
C
K
A
A
I
A
W
K
T
G
-
S
P
L
C
I
E
E
I
E
V
S
P
P
K
----------------
A
C
E
V
--
R
I
Q
V
I
A
T
C
V
C
P
T
D
-
I
N
A
------
T
D
P
K
-
K
K
---------
A
L
F
P
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
N
F
K
P
G
D
K
V
I
P
F
F
A
P
Q
C
K
R
C
K
L
C
L
S
P
L
T
N
L
C
G
----
K
---
L
R
N
F
K
-------
Y
PTIDQELMEDRTSRFTCKG
R
S
---------------
I
--------------
Y
H
F
----------------
M
----
G
V
S
S
F
--
S
Q
Y
T
V
V
S
E
A
--
N
--
L
A
R
V
D
D
E
----
A
N
----
L
E
R
----
V
C
L
I
G
C
G
F
S
S
G
Y
G
A
A
I
-
N
T
A
K
V
T
P
G
S
T
C
A
V
F
G
L
-
G
C
V
G
L
S
A
I
I
G
C
K
I
A
G
A
S
R
I
I
A
I
D
I
N
G
E
K
F
P
K
A
K
A
L
G
A
T
D
C
L
N
P
R
E
L
D
K
P
V
Q
D
V
I
T
E
L
T
--
A
-
G
G
---
V
D
Y
S
L
D
C
A
G
T
A
-----------------------
Q
T
L
K
A
A
V
D
C
T
V
L
-
G
W
G
S
C
T
V
V
G
A
K
V
D
E
-------------
M
T
I
P
T
V
D
V
I
-
L
G
R
S
I
N
G
T
F
F
GG
W
---
K
--
S
--
V
D
S
V
P
N
L
V
S
D
Y
K
N
K
K
-
F
D
L
D
L
L
V
T
-
H
A
L
P
-
F
E
S
I
N
D
A
I
D
L
M
K
E
G
----------------
77
Fugue
46.18
25%
-38
- C1 -
1TEH
3
ADHX_HUMAN
A:
[1-373]
-
A
N
E
V
I
K
C
K
A
A
V
A
W
E
A
G
K
-
P
-
L
S
I
E
E
I
E
V
A
P
---------
P
K
A
-------
H
E
V
--
R
I
K
I
I
A
T
A
V
C
H
T
D
-
A
Y
T
------
L
S
G
A
D
P
E
---------
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
----
K
---
I
R
V
T
Q
-------
G
-------------------
K
G
LMPDGTSRF------
T
--------------
C
K
G
---
K
T
I
---------
L
H
----
Y
M
G
T
S
TF
S
E
Y
T
V
V
A
D
I
--
S
---
V
A
K
I
D
P
L
A
P
L
D
K
----
V
C
L
----
L
G
C
---
G
I
S
T
G
Y
G
A
A
V
N
T
-
A
K
L
E
P
G
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
-
K
P
I
Q
E
V
L
I
E
M
--
T
D
G
G
---
V
D
Y
S
F
E
C
I
G
-----------------------
N
V
K
V
M
R
A
A
L
E
A
C
H
K
-
G
-
W
-----
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
---
G
-
G
--
W
---
K
--
S
--
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
-
I
K
V
D
E
F
V
T
-
H
N
L
S
-
F
D
E
I
N
K
A
F
E
L
M
H
S
G
-
K
S
I
R
T
V
V
K
I
------
95
HHSearch
44.98
22%
-22
- C1 -
1F8F
6
?
A:
[4-370]
-----
L
K
D
I
I
A
A
V
T
P
C
K
G
-
A
D
F
E
L
Q
A
L
K
I
R
Q
P
Q
----------------
G
D
E
V
--
L
V
K
V
V
A
T
G
M
C
H
T
D
-
L
I
V
------
R
D
Q
K
-
Y
P
---------
V
P
L
P
A
V
L
G
H
E
G
S
G
I
I
E
A
I
G
P
N
V
T
E
L
Q
V
G
D
H
V
V
L
S
Y
G
-
Y
C
G
K
C
T
Q
C
N
T
G
N
P
A
Y
C
S
----
E
---
F
F
G
R
N
FSGADSE
G
-------------------
N
H
---------------
A
LCVN----------
D
H
F
----------------
F
----
A
Q
S
S
F
--
A
T
Y
A
L
S
R
E
N
--
N
--
T
V
K
V
T
K
D
----
V
P
----
I
E
L
----
L
G
P
L
G
C
G
I
Q
T
G
A
G
A
C
I
-
N
A
L
K
V
T
P
A
S
S
F
V
T
W
G
A
-
G
A
V
G
L
S
A
L
L
A
A
K
V
C
G
A
S
I
I
I
A
V
D
I
V
E
S
R
L
E
L
A
K
Q
L
G
A
T
H
V
I
N
S
K
T
Q
--
D
P
V
A
A
I
K
E
I
T
--
D
-
G
G
---
V
N
F
A
L
E
S
T
G
S
P
-----------------------
E
I
L
K
Q
G
V
D
A
L
G
I
-
L
-
G
K
I
A
V
V
G
A
P
Q
L
G
T
-----------
T
A
Q
F
D
V
N
D
L
L
L
G
G
K
T
I
L
G
V
V
E
GS
G
---
S
--
P
--
K
K
F
I
P
E
L
V
R
L
Y
Q
Q
G
K
-
F
P
F
D
Q
-
L
V
-
K
F
Y
A
-
F
D
E
I
N
Q
A
A
I
D
S
R
K
G
-
I
T
L
K
P
I
I
K
I
------
97
HHSearch
44.75
24%
-6
- C1 -
4RQT
6
ADH1_ARATH
A:
[1-374]
---
S
Q
I
I
R
C
K
A
A
V
A
W
E
A
G
-
K
P
L
V
I
E
E
V
E
V
A
P
P
Q
----------------
K
H
E
V
--
R
I
K
I
L
F
T
S
L
C
H
T
D
-
V
Y
F
------
W
E
A
K
-
G
Q
T--------
P
L
F
P
R
I
F
G
H
E
A
G
G
I
V
E
S
V
G
E
G
V
T
D
L
Q
P
G
D
H
V
L
P
I
F
T
G
E
C
G
E
C
R
H
C
H
S
E
E
S
N
M
C
D
----
L
---
L
R
I
N
T
-------
E
RG-----------------
G
M
---------------
I
HDGESRFSING
K
P
I
Y
H
F
----------------
L
----
G
T
S
T
F
--
S
E
Y
T
V
V
H
S
G
--
Q
--
V
A
K
I
N
P
D
----
A
P
----
L
D
K
----
V
C
I
V
S
C
G
L
S
T
G
L
G
A
T
L
-
N
V
A
K
P
K
K
G
Q
S
V
A
I
F
G
L
-
G
A
V
G
L
G
A
A
E
G
A
R
I
A
G
A
S
R
I
I
G
V
D
F
N
S
K
R
F
D
Q
A
K
E
F
G
V
T
E
C
V
N
P
K
D
H
D
K
P
I
Q
Q
V
I
A
E
M
T
---
D
G
G
---
V
D
R
S
V
E
C
T
G
S
V
-----------------------
Q
A
M
I
Q
A
F
E
C
V
H
D
-
G
W
G
V
A
V
L
V
G
V
P
S
K
D
D
-----------
A
F
K
T
H
P
-
M
N
F
L
N
E
R
T
L
K
G
T
F
F
--
G
---
N
--
Y
KP
K
T
D
I
P
G
V
V
E
K
Y
M
N
K
E
-
L
E
L
E
K
F
I
T
-
H
T
V
P
-
F
S
E
I
N
K
A
F
D
Y
M
L
K
G
-
E
S
I
R
C
I
I
T
M
G
-----
91
HHSearch
44.57
24%
-14
- C1 -
3UKO
10
ADHX_ARATH
A:
[4-377]
---
G
Q
V
I
T
C
K
A
A
V
A
Y
E
P
N
-
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
----------------
A
G
E
V
--
R
I
K
I
L
Y
T
A
L
C
H
T
D
-
A
Y
T
------
W
S
G
K
-
D
P
E--------
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
----
K
---
V
R
S
A
T
-------
G
-------------------
V
G
---------------
I
--------------
M
M
N
DRK
S
R
F
S
V
NG
K
P
I
Y
H
F
M
----
G
T
S
T
F
--
S
Q
Y
T
V
V
H
D
V
--
S
--
V
A
K
I
D
P
T
----
A
P
----
L
D
K
----
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
-
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
-
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
---
D
G
G
---
V
D
Y
S
F
E
C
I
G
N
V
-----------------------
S
V
M
R
A
A
L
E
C
C
H
K
-
G
W
G
T
S
V
I
V
G
V
A
A
S
G
Q
-----------
E
I
S
T
R
P
F
Q
-
L
V
T
G
R
V
W
K
G
T
A
F
--
G
GF-
K
--
S
--
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
-
I
K
V
D
E
Y
I
T
-
H
N
L
T
-
L
G
E
I
N
K
A
F
D
L
L
H
E
G
-
T
C
L
R
C
V
L
D
T
S
-----
83
HHSearch
42.85
24%
-25
- C1 -
1JVB
2
ADH_SULSO
A:
[1-347]
--------
M
R
A
V
R
L
V
E
I
G
-
K
P
L
S
L
Q
E
I
G
V
P
K
P
K
----------------
G
P
Q
V
--
L
I
K
V
E
A
A
G
V
C
H
S
D
-
V
H
M
------
R
Q
G
R
-
F
G
NLRIVEDLG
V
K
L
P
V
T
L
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
G
Y
S
K
G
D
L
V
A
V
N
P
W
Q
G
E
G
N
C
Y
Y
C
R
I
G
E
E
H
L
C
D
----
S
---
P
R
W
-------------------------------------------------------------
L
G
I
----------------
N
----
F
D
G
A
Y
--
A
E
Y
V
I
V
P
H
Y
--
K
--
Y
M
Y
K
L
R
R
----
L
N
----
A
V
E
----
A
A
P
L
T
C
S
G
I
T
T
Y
R
A
V
R
-
K
-
A
S
L
D
P
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
Q
--
D
P
L
A
E
I
R
R
I
T
--
E
S
K
G
---
V
D
A
V
I
D
L
N
N
S
E
-----------------------
K
T
L
S
V
Y
P
K
A
L
A
K
-
Q
-
G
K
Y
V
M
V
G
L
F
G
A
D
L
-------------
H
Y
H
A
P
L
I
T
L
S
E
I
Q
F
V
G
S
-
L
--
V
---
G
--
N
--
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
-
V
K
P
--
M
I
T
-
K
T
M
K
-
L
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
I
P
------
99
HHSearch
42.17
24%
-20
- C1 -
2FZW
6
ADHX_HUMAN
A:
[3-364]
----
E
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
-
L
S
I
E
E
I
E
V
A
P
P
K
----------------
A
H
E
V
--
R
I
K
I
I
A
T
A
V
C
H
T
D
-
A
Y
T
------
L
S
G
A
-
D
P
E--------
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
----
K
---
I
R
V
T
Q
-------
G
-------------------
K
G
LMPDGTSRFTCKG
K
T
I
--------------
L
H
Y
----------------
M
----
G
T
S
T
F
--
S
E
Y
T
V
V
A
D
I
--
S
--
V
A
K
I
D
P
L
----
A
P
----
L
D
K
----
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
-
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
---
D
G
G
---
V
D
Y
S
F
E
C
I
G
N
V
-----------------------
K
V
M
R
A
A
L
E
A
C
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
-----------
E
I
A
T
R
P
F
Q
-
L
V
T
G
R
T
W
K
G
T
A
F
--
G
---
G
WK
S
--
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
-
I
K
V
D
E
F
V
T
-
H
N
L
S
-
F
D
E
I
N
K
A
F
E
L
M
H
S
G
----------------
53
PsiBlast_CBE
33.55
31%
-22
- C1 -
1CDO
3
ADH1_GADMC
B:
[6-271]
------------
V
I
K
C
K
A
-
A
-
V
A
W
E
-
A
N
K
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
---------
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
H
L
------
F
E
G
K
-
H
K
---------
D
G
F
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
KGWA
N
---
E
S
P
D
V
-------
M
-------------------
S
P
---------------
K
--------------
E
T
R
---
F
T
C
---------
K
G
RKVL
Q
F
L
G
T
--
S
T
F
S
Q
Y
T
V
V
--
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
----
V
-------
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
-
A
K
V
E
P
G
S
T
C
A
V
F
G
L
-
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
D
H
S
----
E
P
I
S
Q
V
L
--
S
K
M
T
NGG
V
D
F
S
L
E
C
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
29.16
31%
-42
- C1 -
2EJV
3
TDH_THET8
B:
[28-246]
----------------------------------------------------
I
--
L
V
R
V
E
A
A
S
I
C
G
T
D
-
L
H
I
WKWDAW
A
R
G
R
-
I
R
---------
P
P
--
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
----
N
TQI
L
G
V
D
R
-------
D
-------------------
G
----------------------------------------------------------
G
F
--
A
E
Y
V
V
V
P
A
E
--
N
A
W
V
-------
N
P
K
D
L
----
P
F
E
----
V
A
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
-
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
A
D
-
R
L
V
N
P
L
E
E
D
-
L
L
-
E
V
V
R
R
V
T
--
G
S
-
G
---
V
E
V
L
L
E
F
S
G
N
E
A
---
A
I
H
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
28.94
31%
-45
- C1 -
2EJV
3
TDH_THET8
A:
[28-246]
----------------------------------------------------
I
--
L
V
R
V
E
A
A
S
I
C
G
T
D
-
L
H
I
W
K
WD
A
W
A
R
G
R
-
I
R
---------
P
P
--
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
----
N
T
Q
I
L
G
V
D
R
-------
D
-------------------
G
----------------------------------------------------------
G
F
--
A
E
Y
V
V
V
P
A
E
--
N
A
W
V
-------
N
P
K
D
L
----
P
F
E
----
V
A
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
-
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
A
D
-
R
L
V
N
P
L
E
E
D
-
L
L
-
E
V
V
R
R
V
T
--
G
S
-
G
---
V
E
V
L
L
E
F
S
G
N
E
A
---
A
I
H
----------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
28.52
31%
-44
- C1 -
2DQ4
3
TDH_THET8
A:
[28-246]
----------------------------------------------------
I
--
L
V
R
V
E
A
A
S
I
C
G
T
D
-
L
H
I
W
K
WD
A
W
A
R
G
R
-
I
R
---------
P
P
--
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
----
N
T
Q
I
L
G
V
D
R
-------
D
-------------------
G
----------------------------------------------------------
G
F
--
A
E
Y
V
V
V
P
A
E
--
N
A
W
V
-------
N
P
K
D
L
----
P
F
E
----
V
A
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
-
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
A
D
-
R
L
V
N
P
L
E
E
D
-
L
L
-
E
V
V
R
R
V
T
--
G
S
-
G
---
V
E
V
L
L
E
F
S
G
N
E
A
---
A
I
H
----------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
26.48
31%
-44
- C1 -
2DQ4
3
TDH_THET8
B:
[28-246]
----------------------------------------------------
I
--
L
V
R
V
E
A
A
S
I
C
G
T
D
-
L
H
I
WKWDAW
A
R
G
R
-
I
R
---------
P
P
--
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
----
N
TQI
L
G
V
D
R
-------
D
-------------------
G
----------------------------------------------------------
G
F
--
A
E
Y
V
V
V
P
A
E
--
N
A
W
V
-------
N
P
K
D
L
----
P
F
E
----
V
A
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
-
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
A
D
-
R
L
V
N
P
L
E
E
D
-
L
L
-
E
V
V
R
R
V
T
--
G
S
-
G
---
V
E
V
L
L
E
F
S
G
N
E
A
---
A
I
H
----------------------------------------------------------------------------------------------------------------------------------------------------