@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACKR4_HUMAN: (2016-01-08 )
MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
Atome Classification :
(20 SA)
.........10..----......20........30........40........50-------.........60........70........80........90..--..---....100--..--.--.....110.......120.......130.......140--.--------.-......150---...--..-....160.--........170..----.-..-----.---.180---..---..---.-----.-..--.190-......---...-----200.....---..210.......220------.....--.---------------------------------.230----------------.------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------...-----------------------------------------------...240---.........250.......-------------260-..-......270---.........280.......---290.......300--------.......310.......--------320.......330.......340.......350------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALEQNQST
D
Y
Y
Y
----EENEMNGTYDYS
Q
Y
E
L
I
C
I
K
E
D
V
R
E
F
A
K
V
F
L
P
V
F
L
T
I
--------
V
F
V
I
GLAGN
S
M
V
V
A
I
Y
A
Y
Y
K
KQRTKT
D
V
Y
I
L
N
L
A
V
A
D
L
L
L
L
F
T
--
L
P
---
F
W
A
V
N
-
A
--
V
H
--
G
--
W
V
L
G
K
I
M
C
K
I
T
S
A
L
Y
T
L
N
F
VSG
M
Q
F
L
A
C
ISID
R
Y
V
A
V
---T--------K-VPSQSGV-----GK
P
--
C
W
-
I
I
C
F
C
--
V
--
W
M
A
A
I
L
L
SIP
Q
L
V
----
F
-
Y
T
-----V---ND-----N
A
---
R
C
---
I
-----
P
-I
F
--
P
R
---
Y
L
G
T
S
M
---
K
A
L
-----
I
Q
M
L
E
I
C
I
---
G
F
V
V
P
F
L
I
M
G
V
C
Y
F
I
------
T
A
R
T
L
--
M
---------------------------------KM------------------P------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--------------
K
IS-----------------------------------------------
R
P
L
K
-----
V
L
L
T
V
V
I
V
F
I
V
T
QL
P
Y
N
I
V
-------------
K
F
--
C
R
-
A
I
D
I
I
Y
S
-----
L
I
T
SCNMSK
R
M
D
I
A
I
Q
V
T
E
---
S
I
A
L
F
H
S
C
L
N
P
I
L
--------
Y
V
F
MG
A
S
F
K
N
Y
V
M
K
V
A
K
--------
K
Y
G
S
W
R
R
Q
R
Q
S
V
E
EFPFDSEGPTEPTSTFSI--------------------------------------------------------------------------------------------------------------
28
HHSearch
89.42
33%
-144
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-498]
---------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
--------
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
---
F
W
A
V
D
-
A
--
V
A
--
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
---
V
--------
H
-
A
T
N
S
Q
R
P
R
K
---
L
L
A
--
E
K
-
V
V
Y
V
G
--
V
--
W
I
P
A
L
L
L
T
I
P
D
F
I
----
F
-
A
N
-----
V
---
S
E
A
D---
D
R
---
Y
I
---
C
-----
D
-
R
F
-------
Y
P
N
D
L
W
---
V
V
V
-----
F
Q
F
Q
H
I
M
V
---
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
------
I
I
S
K
L
--
S
---------------------------------
H
S
------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
--------------
Q
K
R
-----------------------------------------------
K
A
L
K
-----
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
-------------
I
S
--
I
D
-
S
F
I
L
L
E
I
-----
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
---
A
L
A
F
F
H
C
C
L
N
P
I
L
--------
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
--------
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.62
28%
-149
- C4 -
4MBS
8
CCR5_HUMAN (first)
A:
[22-366]
----------------------------------
C
Q
K
I
N
V
K
Q
I
A
A
R
L
L
P
P
L
Y
S
L
--------
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
--
V
P
---
F
W
A
H
Y
-
A
--
A
A
--
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
---
V
--------
H
-
A
V
F
A
L
K
A
-----
R
T
V
--
T
F
-
G
V
V
T
S
--
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
----
F
-
T
R
-----
S
---
Q
K
-----
E
G
L
H
Y
T
C
---
S
-----
S
-
H
F
--
P
----
Y
S
Q
Y
Q
F
---
W
K
N
-----
F
Q
T
L
K
I
V
I
L
--
G
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
------
I
L
K
T
L
--
L
---------------------------------
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGD
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--------------
G
V
N
PGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
E
E
EK
K
R
H
-------------
R
D
V
R
-----
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
-------------
L
L
--
L
N
-
T
F
Q
E
F
F
G
-----
L
-
N
N
C
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
---
T
L
G
M
T
H
C
C
I
N
P
I
I
--------
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
78.29
28%
-150
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------
S
F
K
C
-
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
--------
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
---
A
L
I
F
Y
-
Y
--
F
N
--
K
TD
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
---
V
--------
Y
-
P
K
S
L
G
R
L
-----
K
K
K
--
N
A
-
I
C
I
S
V
--
L
--
V
W
L
I
V
V
V
A
I
S
P
I
L
----
F
-
Y
S
G
T
G
V
R
K
---
N
K
-----
T
I
---
T
C
---
Y
DTTSD
E
-
Y
L
--
R
S
---
Y
F
I
Y
S
M
---
C
T
T
-----
V
A
M
---------
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
------
I
V
R
A
L
--
I
Y
--------------------------------
K
M
------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--------------
T
C
T
VCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
-----
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
-------------
K
T
--
M
N
L
R
A
R
L
D
F
Q
-----
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.09
28%
-155
- C4 -
4XT1
15
US28_HCMVA
A:
[23-318]
--------------------------
D
Y
D
E
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
V
T
L
F
L
Y
G
V
--------
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
--
L
P
---
L
W
M
Q
Y
-
L
--
L
D
---------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
---
V
--------
Y
-
M
R
Y
R
P
-
V
-----
K
Q
A
--
C
L
-
F
S
I
F
---
W
--
W
I
F
A
V
I
I
A
I
P
H
F
M
----
V
-
V
T
-----
K
---
K
D
-----
N
----
Q
C
---
M
-----
T
-
D
Y
--
D
----
Y
L
E
V
S
Y
---
P
I
I
-----
L
N
V
E
L
M
L
G
---
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
------
I
S
R
I
V
--
A
---------------------------------
V
S
------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
H
K
G
-----------------------------------------------
R
I
V
R
-----
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
-------------
L
F
--
V
D
-
T
L
K
L
L
K
W
-----
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
---
S
L
A
F
C
H
C
C
L
N
P
L
L
--------
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
--------
E
F
----
R
--------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
77.02
27%
-127
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
--------
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
---
F
W
A
V
D
-
A
--
V
A
--
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
---
V
H-------
A
-
T
N
S
Q
R
P
R
-----
K
L
L
--
A
E
K
V
V
Y
V
G
--
V
--
W
I
P
A
L
L
L
T
I
P
D
F
I
----
F
-
A
N
-----
V
---
S
E
-----
A
D
---
D
R
---
Y
-----
I
-
C
D
--
R
F
---
Y
P
N
D
L
W
---
V
V
V
-----
F
Q
F
Q
H
I
M
V
---
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
------
I
I
S
K
L
--
S
---------------------------------
H
-------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------
N
I
F
-----------------------------------------------
E
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
--
K
S
-
E
L
D
K
A
I
G
RNTNG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
---
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
16
PsiBlast_PDB
76.65
27%
-147
- C4 -
4N6H
22
OPRD_HUMAN
A:
[133-411]
----------------------------------------------------
S
A
--------
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
---
F
Q
S
A
K
Y
L
--
M
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
---
C
HPVKALDF
R
-
T
P
A
K
A
K
--------------
L
I
N
I
C
--
I
--
W
V
L
A
S
G
V
G
V
P
I
M
V
----
M
-
A
V
-----
T
R
P
-
R
D
-----
G
A
V--
V
C
---
M
-----
L
-
Q
F
--
P
S
P
S
W
Y
W
D
T
V
T
---
K
------------
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
------
M
L
L
R
L
--
R
S
V
RLLSGS-------------------------
K
E
------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
S
L
R
-----------------------------------------------
R
I
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
-------------
V
---------
I
V
W
T
-----
L
V
D
I
D
R
R
D
P
L
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
--------
K
P
C
G
-----------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
75.93
17%
-122
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
E
G
P
N
F
Y
V
PFSN
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
--------
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
---
T
T
T
L
Y
-
T
--
S
L
H
G
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
---
C
--------
K
P
M
S
N
F
R
F
G
-----
E
N
H
--
A
I
-
M
G
V
A
F
--
T
--
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
-
I
P
-----
E
---
G
M
-----
Q
C
---
S
C
---
G
-----
I
D
Y
Y
--
T
P
---
H
E
E
T
N
N
---
E
S
F
-----
V
I
Y
M
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
--
K
---------------------------------
E
A
------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------
A
T
T
-----------------------------------------------
Q
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
-------------
P
Y
--
A
G
-
V
A
F
Y
I
F
T
-----
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
---
T
S
A
V
----
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
--------
C
------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.68
28%
-148
- C4 -
4XT3
2
US28_HCMVA
A:
[26-316]
-----------------------------
E
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
V
T
L
F
L
Y
G
V
--------
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
--
L
P
---
L
W
M
Q
Y
-
L
--
L
D
--
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
---
V
--------
Y
-
M
R
Y
R
P
-
V
-----
K
Q
A
--
C
L
-
F
S
I
F
---
W
--
W
I
F
A
V
I
I
A
I
P
H
F
M
----
V
-
V
T
-----
K
---
K
D
-----
N
----
Q
C
---
M
-----
T
-
D
Y
--
D
----
Y
L
E
V
S
Y
---
P
I
I
-----
L
N
V
E
L
M
L
G
---
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
------
I
S
R
I
V
--
A
---------------------------------
V
S
------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
H
K
G
-----------------------------------------------
R
I
V
R
-----
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
-------------
L
F
--
V
D
-
T
L
K
L
L
K
W
-----
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
---
S
L
A
F
C
H
C
C
L
N
P
L
L
--------
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
--------
E
--------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
75.47
20%
-152
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
-------------------------------------------
E
V
V
F
I
V
L
V
A
G
S
--------
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
L
Y
-
T
V
-
I
G
--
Y
--
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
---
T
--------
K
-
P
L
T
Y
P
V
K
RT---
T
K
M
--
A
G
-
M
M
I
A
A
--
A
--
W
V
L
S
F
I
L
W
A
P
A
I
L
----
F
-
W
Q
-----
F
---
I
V
GVRTV
E
D
---
G
E
---
C
-----
Y
-
I
Q
-------
F
F
---
S
---
N
A
A
-----
V
T
F
G
T
A
I
A
---
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
------
I
S
R
A
S
--
K
---------------------------------
S
R
------------------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------
R
E
K
-----------------------------------------------
K
V
T
R
-----
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
-------------
V
L
--
I
N
-
T
F
C
A
P
C
I
---------------
P
N
T
V
W
T
I
G
Y
---
W
L
C
Y
I
N
S
T
I
N
P
A
C
--------
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.10
27%
-149
- C4 -
4RWD
6
C562_ECOLX (first)
A:
[130-406]
----------------------------------------------------
S
A
--------
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
---
F
Q
S
A
K
Y
L
--
M
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
---
C
H
P
V
K
A
L
D
F
R
-
T
P
A
K
A
K
--------------
L
I
N
I
C
--
I
--
W
V
L
A
S
G
V
G
V
P
I
M
V
----
M
-
A
V
-----
T
R
P
-
R
D
-----
G
A
V
--
V
C
---
M
-----
L
-
Q
F
--
P
S
P
S
W
Y
W
D
T
V
T
---
K
------------
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
------
M
L
L
R
L
--
R
S
V
RLLSGS-------------------------
K
E
------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
S
L
R
-----------------------------------------------
R
I
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
-------------
V
---------
I
V
W
T
-----
L
V
D
I
D
R
R
D
P
L
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.80
26%
-144
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[121-401]
------------------------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
--
L
P
---
F
Q
G
T
D
-
I
--
L
L
--
G
F-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
---
C
--------
H
-
P
------T----
S
S
K
--
A
Q
-
A
V
N
V
A
--
I
--
W
A
L
A
S
V
V
G
V
P
V
A
I
----
M
-
G
S
-----
A
Q
VE
D
E
-----
E
I
---
E
C
L
V
E
I
-----
P
-
T
P
--
Q
D
---
Y
W
G
P
---------------
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
------
M
I
R
R
L
--
R
---------------------------------
G
V
------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------
S
G
S
-----------------------------------------------
R
E
K
D
-----
R
N
L
R
R
I
T
R
L
V
L
V
V
--
V
A
V
F
-------------
V
G
--
C
W
-
T
P
V
Q
V
F
V
-----
L
A
Q
G
L
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
--------
Y
A
F
L
D
E
N
F
K
A
C
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
72.56
33%
-119
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
--------
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
---
I
W
A
A
S
-
K
--
V
N
--
G
--
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
---
V
--------
H
-
A
T
R
T
L
T
Q
K
----
R
H
L
--
V
K
-
F
V
C
L
G
--
C
--
W
G
L
S
M
N
L
S
L
P
F
F
L
----
F
-
R
Q
-----
A
---
Y
H
PNN--
S
S
---
P
V
---
C
-----
Y
-
E
V
--
L
G
---
N
D
T
A
K
W
---
R
M
V
-----
L
R
I
L
P
H
T
F
---
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
------
T
L
R
T
L
--
F
---------------------------------
K
A
------------------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------
Q
K
H
-----------------------------------------------
R
A
M
R
-----
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
-------------
L
L
--
A
D
-
T
L
M
R
T
Q
V
-----
I
Q
E
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
---
I
L
G
F
L
H
S
C
L
N
P
I
I
--------
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
--------
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
72.51
20%
-140
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------
Y
A
L
S
Y
C
A
--------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V-
M
P
---
W
V
V
Y
L
-
E
V
T
G
G
--
V
--
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
---
V
--------
M
-
P
V
H
Y
Q
H
G
T
G
Q
SS
C
R
R
--
V
A
-
L
M
I
T
A
--
V
--
W
V
L
A
F
A
V
S
C
P
L
L
F
----
G
-
F
N
-----
T
---
T
G
-----
D
P
---
T
V
---
C
-----
S
-
I
S
-------
N
---------
P
D
-----
F
V
I
Y
S
S
V
V
---
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
------
I
Y
V
V
L
--
K
---------------------------------
Q
R
------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
--------------
R
E
K
-----------------------------------------------
K
A
T
Q
-----
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
-------------
H
V
--
L
N
-
T
H
C
Q
T
C
--------------
H
V
S
P
E
L
Y
S
A
T
T
---
W
L
G
Y
V
N
S
A
L
N
P
V
I
--------
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
--------
C
--------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.04
27%
-146
- C4 -
4RWA
2
C562_ECOLX (first)
A:
[130-406]
----------------------------------------------------
S
A
--------
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
---
F
Q
S
A
K
Y
L
--
M
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
---
C
H
P
V
K
A
L
D
F
R
-
T
P
A
K
A
K
--------------
L
I
N
I
C
--
I
--
W
V
L
A
S
G
V
G
V
P
I
M
V
----
M
-
A
V
-----
T
R
P
-
R
D
-----
G
A
V
--
V
C
---
M
-----
L
-
Q
F
--
P
S
P
S
W
Y
W
D
T
V
T
---
K
------------
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
------
M
L
L
-----GS-------------------------------
K
E
------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
S
L
R
-----------------------------------------------
R
I
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
-------------
V
---------
I
V
W
T
-----
L
V
D
I
D
R
R
D
P
L
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.01
35%
-117
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[47-324]
----------------------------------------------------
A
L
--------
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
---
I
W
A
A
S
-
K
--
V
N
--
G
--
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
VHA
T
--------
R
-
T
L
T
Q
K
-------
R
H
L
--
V
K
-
F
V
C
L
G
--
C
--
W
G
L
S
M
N
L
S
L
P
F
F
L
----
F
-
R
Q
-----
A
---
Y
H
-----
P
N
---
N
S
---
S
-----
P
-
V
C
--
Y
E
---
V
L
G
N
D
T
AKW
R
M
V
-----
L
R
I
L
P
H
T
F
---
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
------
T
L
R
T
L
--
F
---------------------------------
K
A
------------------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------
Q
K
H
-----------------------------------------------
R
A
M
R
-----
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
-------------
L
L
--
A
D
-
T
L
M
R
T
Q
V
-----
I
Q
E
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
---
I
L
G
F
L
H
S
C
L
N
P
I
I
--------
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
--------
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.77
31%
-145
- C4 -
5C1M
7
?
A:
[25-293]
----------------------------------------------------
S
I
--------
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
---
F
Q
S
V
N
-
Y
--
L
M
--
G
T-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
---
C
--------
H
-
P
V
K
A
L
D
F
-----
R
T
P
R
N
A
K
-
I
V
N
V
C
--
N
--
W
I
L
S
S
A
I
G
L
P
V
M
F
----
M
-
A
T
-----
T
K
Y
R
Q
G
-----
S
I
---
D
C
---
T
-----
L
-
T
F
S
H
P
T
---
W
Y
W
E
--------------
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
K
S
V
R
M
L
SG
S
---------------------------------
K
E
------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
N
L
R
-----------------------------------------------
R
I
T
R
-----
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
-------------
V
I
--
I
K
-
A
L
-
I
T
I
P
-----
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
---------
N
S
C
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
C
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.51
24%
-142
- C4 -
4XNW
2
RUBR_CLOPA
A:
[52-382]
----------------------------------------------
Y
L
P
A
V
Y
I
L
--------
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
-
K
--
T
D
-----
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
---
V
--------
Y
-
P
L
K
S
L
G
R
-----
L
K
K
--
K
N
-
A
I
C
I
S
V
L
V
--
W
L
-
I
V
V
V
A
I
S
P
I
L
----
F
-
Y
S
---------
G
T
-----
G
V
---
R
K
---
N
-----
K
-
T
I
--
T
C
---
Y
D
T
T
S
D
---
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
---
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
------
I
V
R
A
L
--
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFK
D
I
------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
WVCPLCGVGKDQ
F
E
E
V
E
-----------------------------------------------
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
-------------
K
T
M
N
L
R
-
A
-
R
L
D
F
Q
-----
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
71.41
20%
-124
- C4 -
2Z73
5
OPSD_TODPA
A:
[25-336]
-----------------------------------
E
F
D
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
--------
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
-
C
F
-
L
K
--
K
--
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
---
G
--------
R
-
P
M
A
A
S
K
K
M
S
---
H
R
R
--
A
F
-
I
M
I
I
F
--
V
--
W
L
W
S
V
L
W
A
I
G
P
I
F
----
G
-
W
G
-----
A
---
Y
T
L
E
G--
V
L
---
C
N
---
C
-----
S
-
F
D
--
Y
I
---
S
-
R
D
S
T
---
T
R
S
-----
N
I
L
C
M
F
I
L
---
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
------
I
V
M
S
V
--
S
---------------------------------
N
H
------------------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--------------
A
E
M
-----------------------------------------------
R
L
A
K
-----
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
-------------
A
L
--
L
A
-
Q
F
G
P
L
E
--------------
W
V
T
P
Y
A
A
Q
L
P
V
---
M
F
A
K
A
S
A
I
H
N
P
M
I
--------
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
--------
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------------------------------------------------------------------------------------------------------------------
36
HHSearch
71.08
19%
-140
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------
P
L
V
V
V
L
S
T
--------
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
L
Y
-
L
L
-
M
S
--
K
--
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
---
Q
--------
Q
-
P
L
R
Y
L
K
Y
RT---
K
T
R
--
A
S
-
A
T
I
L
G
--
A
--
W
F
L
S
F
L
W
V
I
P
I
L
G
----
W
-
N
H
-----------R----
R
E
---
D
K
---
C
-----
E
-
T
D
-------
F
Y
D
V
------
T
W
-----
F
K
V
M
T
A
I
I
---
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
------
I
Y
K
A
V
--
R
---------------------------------
Q
H
------------------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--------------
R
E
R
-----------------------------------------------
K
A
A
K
-----
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
-------------
F
M
--
V
I
-
A
F
C
K
N
C
C
---------------
N
E
H
L
H
M
F
T
I
---
W
L
G
Y
I
N
S
T
L
N
P
L
I
--------
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
--------
I
--------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
71.04
21%
-146
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
-----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
--------
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V-
V
P
---
F
G
A
A
H
-
I
L
-
M
K
--
M
--
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
--------
S
-
P
F
K
Y
Q
S
L
LT---
K
N
K
--
A
R
-
V
I
I
L
M
--
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
----
M
H
W
Y
-----
R
---
A
T
H
Q
---
E
A
---
I
N
---
C
-----
Y
-
A
E
--
E
T
---
C
C
D
F
F
T
---
N
Q
A
-----
Y
A
I
A
S
S
I
V
---
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
--
K
---------------------------------
R
Q
------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
--------------
K
E
H
-----------------------------------------------
K
A
L
K
-----
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
-------------
N
I
--
V
H
-
V
I
Q
D
N
L
I
---------------
R
K
E
V
Y
I
L
L
N
---
W
I
G
Y
V
N
S
G
F
N
P
L
I
--------
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------
L
--------------------------------------------------------------------------------------------------------------------------------------------