@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CNR2_HUMAN: (2016-01-09 )
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100---.......110.--.....-.120........130.......140..---.....150.......160.......170...--------------...-------..---------.180----..-------.-...---..190.......-200-......--..210.......220......------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------230---------------------------------------------------------------------------------------------.--------------..---......240.......250.......260.......270..-.....-280....--...290.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEE
C
W
V
T
E
IANGSKDGLDSNPMK
D
Y
M
I
LSGP
Q
K
T
A
V
A
V
L
C
T
L
L
G
L
L
S
A
L
E
N
V
A
V
L
Y
L
I
LS
S
H
Q
LRRKP
S
Y
L
F
I
GSLA
G
A
D
F
L
A
S
V
V
F
A
C
S
F
V
N
F
H
V
FHGVDS---
K
A
V
F
L
L
K
IG
S
V
--
T
M
T
F
T
-
A
S
-
V
G
S
L
L
L
T
A
I
D
R
Y
L
CLRYPP
S
Y
K
A
L
---
L
TRGR
A
L
V
T
L
G
I
M
W
V
L
S
A
L
V
S
YLPLM--GWT--------------CCP-------R
P
---------
C
S
E
-----
L
F-------P-LI
P
---
N
D
Y
L
L
S
W
L
L
F
I
A
-
F
-
L
-
F
S
G
I
I
Y
--
T
Y
G
H
V
L
W
K
A
H
Q
H
V
A
S
LSGHQD------------------------------R----------------------------------------------------------------------------------------------------------------------------------------------------Q-----------------------------------------------------------------------------------------------V--------------PG---
M
A
R
M
R
L
D
V
R
L
A
K
T
L
G
L
V
L
A
V
L
L
I
C
W
F
P
V
L
A
L
M
A
H
S
L
A
T
T
L
S
-
D
Q
V
K
K
-
A
F
A
F
C
S
M
--
L
C
L
I
N
S
M
V
N
P
V
I
Y
A
LRSGE
I
R
S
S
A
H
H
C
L
A
H
W
K
K
C
V
R
GLG
S
E
A
K
EEAPRSSVTETEADGKITPWPDSRDLDLSDC
37
HHSearch
94.84
26%
-151
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
-
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
-
Y
T
A
N
L
L
L
S
G
A
T
T
Y
K
L
T--
P
A
Q
W
F
L
R
E
G
S
M
--
F
V
A
L
S
-
A
S
-
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
--
G
W
N
--------------
C
I
S
AL-----
S
S
---------
C
S
T
-----
V
L
-------
P
-
L
Y
H
---
K
H
Y
I
L
F
C
T
T
V
F
T
-
L
-
L
-
L
L
S
I
V
I
--
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
------------------------------
E
GLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT--
W
-----------------------------------------------------------------------------------------------
D
--------------
A
Y
---
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
C
D
I
L
F
-
R
A
E
Y
F
L
V
--
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
------------------------------------------
38
HHSearch
88.74
23%
-141
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-472]
-------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
---
C
H
G
C
L
F
I
A
C
F
V
--
L
V
L
T
Q
-
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
QS-----
Q
G
---------
C
G
E
-----
G
Q
VACLFED
V
-
V
P
M
---
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
-
L
L
L
M
L
G
--
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
------------------------------
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT-
W
-----------------------------------------------------------------------------------------------
D
--------------
A
Y
---
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
-
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------------
19
PsiBlast_PDB
87.65
26%
-157
- C2 -
3VG9
8
?
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
L
A
A
A
D
-
I
A
V
G
V
L
A
I
P
F
A
-
I
T
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
-SQG------
C
G
E
GQV
A
C
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
---
E
S
------------------------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------
L
--------------
P
G
ERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
----------------------------------------
11
PsiBlast_PDB
86.96
27%
-139
- C2 -
2YCW
7
ADRB1_MELGA
A:
[5-299]
--------------------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------
R
--------------
V
M
---
L
M
R
---
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------
20
PsiBlast_PDB
86.92
26%
-151
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
L
A
A
A
D
-
I
A
V
G
V
L
A
I
P
F
A
-
I
T
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
-SQG------
C
G
E
GQ
V
A
C
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
---
E
S
------------------------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------
L
--------------
P
G
ERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-----------------------------------------
15
PsiBlast_PDB
86.62
26%
-165
- C2 -
2YDO
3
?
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
-
I
A
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
-
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
GQVAC
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
---
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
-------------------------
35
HHSearch
86.48
19%
-138
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
--------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
-
S
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
PLG
P
V
V
C
D
L
W
L
A
L
D
--
Y
V
V
S
N
-
A
S
-
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
--
F
W
Q
--------------
F
I
V
GVRTVED
G
E
---------
C
Y
I
-----
Q
F
-------
F
-
S
-
N
---
A
A
V
T
F
G
T
A
I
A
A
F
-
Y
L
P
-
V
I
I
M
T
V
--
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
------------------------------
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
-------------------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
--------------
D
A
---
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
I
P
N
T
-
V
W
T
I
G
Y
W
--
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------
9
PsiBlast_PDB
86.31
28%
-144
- C2 -
4BVN
11
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------
T
--------------
S
R
---
V
M
L
M
R
-
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
--
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
K
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------
17
PsiBlast_PDB
86.22
26%
-164
- C2 -
4UG2
3
?
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
-
I
A
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
-
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
GQVAC
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
----------------------------------------
18
PsiBlast_PDB
85.91
26%
-161
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
-
I
A
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
-
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
P
KEGKAG---
C
G
E
GQVAC
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
---
E
S
------------------------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------
L
--------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
------------------------------
43
HHSearch
85.76
21%
-141
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
-
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
NFS
R
I
C
C
D
V
F
V
T
L
D
--
V
M
M
C
T
-
A
S
-
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
--
G
F
N
--------------
T
T
G
DP-----
T
V
---------
C
S
I
-----
S
N
---------------
P
D
F
V
I
Y
S
S
V
V
S
F
-
Y
-
L
P
F
G
V
T
V
L
--
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
------------------------------
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
-----------------------------------------------------------------------------------------------
W
--------------
D
A
---
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
S
P
E
-
L
Y
S
A
T
T
W
--
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------
16
PsiBlast_PDB
84.77
26%
-164
- C2 -
2YDV
6
?
A:
[16-298]
------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
-
I
A
I
S
T
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
-
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
--------------
N
C
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
GQVAC
L
F
-------
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
-
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
---
E
S
------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
-
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
------------------------
13
PsiBlast_PDB
84.57
27%
-144
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------
R
--------------
V
M
---
L
M
R
---
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------
3
PsiBlast_PDB
83.83
27%
-148
- C2 -
2Y02
13
ADRB1_MELGA
A:
[5-300]
--------------------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
---
V
M
L
M
R
-
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------
12
PsiBlast_PDB
83.74
27%
-142
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------
R
--------------
V
M
---
L
M
R
---
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-------------------------------------------------
6
PsiBlast_PDB
83.32
27%
-147
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[5-300]
--------------------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
---
V
M
L
M
R
-
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------
2
PsiBlast_PDB
83.28
27%
-150
- C2 -
2Y01
12
ADRB1_MELGA
A:
[5-300]
--------------------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
D
PG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
---
V
M
L
M
R
-
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------
1
PsiBlast_PDB
83.28
27%
-150
- C2 -
2Y00
13
ADRB1_MELGA
A:
[5-300]
--------------------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
-
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
---
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
-
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
DED
P
Q
A
L
K
C
Y
Q
DPG
C
C
D
-------
F
V
---------
T
N
R
-----
A
Y
-------
A
-
I
A
S
---
S
--
I
I
S
--
F
Y
I
P
-
L
-
L
-
I
--
M
I
F
--
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
---
V
M
L
M
R
-
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
---
N
I
V
N
V
F
N
-
R
D
L
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------
34
HHSearch
82.82
19%
-136
* C2 *
2Z73
5
OPSD_TODPA
A:
[27-336]
-------------------------
D
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
IFG
F
A
A
C
K
V
Y
G
F
I
G
--
G
I
F
G
F
-
M
S
-
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
--
G
W
G
--------------
A
Y
T
L
E
GVL--
C
N
---------
C
S
F
-----
D
Y
-------
I
-
S
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
-
F
-
G
P
I
L
I
I
F
F
--
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
------------------------------
R
LNAKE-----------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------------------------------------------------------------------------------------
R
--------------
K
A
---
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
-
W
V
T
P
Y
-
A
A
Q
L
P
V
M
--
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------------------
39
HHSearch
82.78
22%
-149
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
---------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
-
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
-
V
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
SLG
R
P
L
C
L
F
W
L
S
M
D
--
Y
V
A
S
T
-
A
S
-
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
---
G
W
N
--------------
H
--RRE----
D
K
---------
C
E
T
-----
D
F
-------
Y
-
D
V
----
T
W
F
K
V
M
T
A
I
I
N
F
-
Y
L
P
-
T
L
L
M
L
W
--
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------------------------------------
T
P
----------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
---
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
C
N
E
H
-
L
H
M
F
T
I
W
--
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------