@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR6_HUMAN: (2016-01-10 )
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.-----......130.----...-----.-----...140......----.150-------------.......160.......170.......---180.......190.......200..-.--..---------..--210---.-.--.------.....-------.220--.----.----------......230.......240-.......250.......--260-----------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------.--------------....270...-----....280.......290.......300.---.---.----.....--310....---...320...---.....330.......340.......350.......360---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNASAASLND
S
Q
V
V
V
V
AAEGAAAAATAAGGPDTGEWGP
P
A
A
A
ALGAGGGANG
S
L
E
L
SSQLSAGPP
G
L
L
L
PAVNP
W
D
V
L
L
C
VS
G
T
V
IAGE
N
A
L
V
V
A
L
IASTPALRTP
M
F
V
L
V
G
S
L
A
T
A
D
L
L
A
G
C
-----
G
L
I
L
H
F
V
F
-
Q
----
Y
LV-----P-----S
E
T
V
S
L
L
T
V
G
F
L
----
V
A
S
F
-------------
A
A
S
V
S
S
L
L
A
I
T
V
D
R
Y
L
S
L
Y
N
A
L
T
Y
Y
SR---
R
T
L
L
G
V
H
L
L
L
A
A
T
W
T
V
SLG
L
G
L
L
P
V-L--
G
W
---------
N
C
--
L
-----
A
-
E
--
R
------
A
A
C
S
V
-------
V
R
P
---
L
----
A
----------
R
S
H
V
A
L
L
S
A
A
F
F
M
V
F
G
I
M
L
-
H
L
Y
V
R
I
C
Q
V
V
W
R
H
A
H
Q
I
--
A
L
Q
-----------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------H-----------------------------------------------------------------------------------------------C--------------LAPP
H
L
A
A
T
R-----KG
V
G
T
L
A
V
V
L
G
TFGASWL
P
F
A
I
Y
C
V
-VG---S---H----EDP
A
V
--
Y
T
Y
A
T
LL---
P
A
T
Y
-
N
S
M
I
---
N
P
I
I
Y
A
F
R
N
Q
E
I
Q
R
A
L
W
L
L
L
C
G
C
F
QSKVPFRSRSPSEV---
16
PsiBlast_PDB
91.99
27%
-160
- C1 -
2Y01
12
ADRB1_MELGA
A:
[3-299]
----------------------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
15
PsiBlast_PDB
91.86
27%
-161
- C1 -
2Y00
13
ADRB1_MELGA
A:
[3-299]
----------------------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
17
PsiBlast_PDB
91.16
27%
-161
- C1 -
2Y02
13
ADRB1_MELGA
A:
[3-299]
----------------------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
20
PsiBlast_PDB
91.14
27%
-158
- C1 -
4AMJ
12
ADRB1_MELGA
A:
[2-299]
---------------------------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
19
PsiBlast_PDB
90.56
27%
-158
- C1 -
2Y04
13
ADRB1_MELGA
A:
[3-299]
----------------------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
18
PsiBlast_PDB
89.56
27%
-159
- C1 -
2Y03
9
ADRB1_MELGA
A:
[3-299]
----------------------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
-
S
L
L
M
A
L
V
----
V
L
L
I
V
A
G
------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
----
W
L
W
-----
G
-----
S
F
L
C
E
L
W
T
-
S
L
D
----
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
--
Y
-----
Q
-
D
--
P
------
G
C
C
D
F
-------
V
T
N
---
R
----
A
----------
Y
A
-
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
---
V
---
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
---
W
L
G
Y
A
N
S
A
M
---
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
36
HHSearch
86.92
24%
-139
* C1 *
3PBL
2
DRD3_HUMAN (first)
A:
[42-472]
---------------------------------------------------------------------------
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
LV
M
--
P
W
V
V
Y
L
E
V
T
G
----
G
V
W
-----
N
FS
R
I
C
C
D
V
F
V
T
L
D
V
M
M
--------
C
-------------
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-
F
--
G
F
---------
N
T
--
T
-----
G
-
D
--
P
------
T
V
C
S
I
-------
S
N
P
---
D
F
---
V
----------
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
--
L
R
I
-----------------------------
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
--------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GT--------------------------------------------------------------------------------
W
--------------
D
A
Y
G
V
P
L
R
E
K
-----
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
-
L
N
---
T
H
C-
Q
TC--
H
V
S
P
E
--
L
Y
S
A
T
T
W
---
L
G
Y
V
-
N
S
A
L
---
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------
30
HHSearch
86.50
23%
-133
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-477]
----------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
AV
V
--
P
F
G
A
A
H
I
L
-
M
----
K
M
W
-----
T
FG
N
F
W
C
E
F
W
T
S
I
D
V
L
C
--------
V
-------------
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
-
H
W
---------
Y
R
--
A
TH---
Q
-
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
-------
F
F
T
N
Q
A
Y
----
A
----------
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
--
I
D
E
-----------------------------
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TG-
T
-----------------------------------------------------------------------------------------------
W
--------------
D
A
Y
K
F
C
L
K
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
I
QD
N
----
L
I
R
K
E
--
V
Y
I
L
L
N
W
---
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
29
HHSearch
86.29
26%
-134
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[64-495]
------------------------------------------------------------------------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
T
--
A
N
L
L
L
S
G
A
-
T
TYKL
T
P
A
-----
Q
-----
W
F
L
R
E
G
S
M
F
V
A
--------
L
-------------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
-
M
--
G
W
---------
N
C
--
I
-----
S
-
A
--
L
------
S
S
C
S
T
-------
V
L
P
---
L
----
Y
H
K
H
Y
------
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
--
D
E
G
-----------------------------
L
RL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT-
W
-----------------------------------------------------------------------------------------------
D
--------------
A
Y
A
S
R
S
S
E
N
V
-----
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
-
L
D
---
V
G
CK
V
KT--
C
D
I
L
F
--
R
A
E
Y
F
L
V
---
L
A
V
L
-
N
S
G
T
---
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------
28
HHSearch
86.09
22%
-128
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[27-457]
---------------------------------------------------------------------------
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
--
N
L
Y
T
L
Y
T
V
-
I
----
G
Y
W
-----
P
LG
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
--------
S
-------------
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-
L
--
F
W
---------
Q
F
--
I
V
GVRT
V
-
E
--
D
------
G
E
C
Y
I
-------
Q
F
F
---
S
N
A
A
V
T
----------
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
--
I
D
E
-----------------------------
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
------------------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
--------------
D
A
Y
P
P
P
S
R
E
K
-----
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
-
I
N
---
T
F
CA
P
----
C
I
P
N
T
--
V
W
T
I
G
Y
W
---
L
C
Y
I
-
N
S
T
I
---
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------
34
HHSearch
85.29
20%
-130
- C1 -
3EML
13
ENLYS_BPT4
A:
[23-472]
-------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
--
P
F
A
I
T
I
S
T
-
G
FCA-
A
C
H
-----
G
-----
C
L
F
I
A
C
F
V
L
V
L
--------
T
-------------
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
---------
N
N
--
C
-----
G
Q---
S
------
Q
G
C
G
E
GQVACLF
E
D
V
---
V
----
P
M
N
Y
M
V
-----
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
--
I
D
E
-----------------------------
G
LRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
-----------------------------------------------------------------------------------------------
D
--------------
A
Y
R
S
T
L
Q
K
E
V
-----
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
-
F
T
---
F
FC-
P
DCS-
H
A
P
L
W
--
L
M
Y
L
A
I
V
---
L
S
H
T
-
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------
7
PsiBlast_PDB
84.37
28%
-147
- C1 -
4GBR
1
ADRB2_HUMAN
A:
[23-285]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
V
P
F
G
A
A
-
H
----
I
L
T
-----
K
-----
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
-------------
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
I
----
D
-----------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------
F
-----------------------------------------------------------------------------------------------
C
--------------
L
K
E
------
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
45
Fugue
81.18
19%
-119
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
----------------
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
---------------
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
----
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
--
T
T
T
L
Y
T
S
L
-
H
G---
Y
F
V
-----
F
-----
G
P
T
G
C
N
L
E
G
F
F
A
----
T
L
G
G
-------------
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-
V
--
G
W
S
--------
R
Y
--
I
-----
P
-
E
GM
Q
------
C
S
C
G
I
DYY----
T
P
H
---
E
----
E
----------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
-
I
V
I
F
F
C
Y
G
Q
L
V
-----
F
--
T
V
K
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------
A
--------------
A
S
A
T
T
Q
K
A
E
K
-----
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
---
H
----
Q
G
S
D
F
--
G
P
I
F
M
T
I
---
P
A
F
F
-
A
K
T
S
AVY
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
4
PsiBlast_PDB
80.92
27%
-142
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[200-462]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
--------------
V
-----
P
-----
F
G
A
A
H
I
L
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
H
-----------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
5
PsiBlast_PDB
80.91
27%
-142
- C1 -
4LDO
3
A:
[200-462]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
--------------
V
-----
P
-----
F
G
A
A
H
I
L
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
H
-----------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
8
PsiBlast_PDB
80.54
25%
-147
- C1 -
3SN6
1
R:
[200-490]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
--------------
V
-----
P
-----
F
G
A
A
H
I
L
T
K
T
W
T
----
F
G
N
F
WCEFWTSIDVLCV
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRQEAI---
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
I
--
D
K
S
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------
R
------------------------CLKEH
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
LNW
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------------------
3
PsiBlast_PDB
80.01
27%
-141
- C1 -
4LDE
3
A:
[200-462]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
--------------
V
-----
P
-----
F
G
A
A
H
I
L
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
H
-----------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
6
PsiBlast_PDB
79.53
27%
-144
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[200-462]
-----------------------------------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
--------------
V
-----
P
-----
F
G
A
A
C
I
L
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
--
Y
-----
A
-
E
--
E
------
T
C
C
D
F
-------
F
T
N
---
Q
----
A
----------
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
-----------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
H
-----------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
---
V
---
I
----
Q
D
N
L
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
31
HHSearch
78.57
19%
-130
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
---------------------------------------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
--
P
M
N
I
L
Y
L
L
-
M
----
S
K
W
-----
S
LG
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
--------
S
-------------
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
--
W
N
---------
H
---------
R
-
R
--
E
------
D
K
C
E
T
-------
D
F
Y
---
D
----
V
T
W
F
K
------
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
--
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------------------------------------------
T
P
----------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
H
M
N
R
E
R
-----
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
-
V
I
---
A
FCK
N
----
C
C
N
E
H
--
L
H
M
F
T
I
W
---
L
G
Y
I
-
N
S
T
L
---
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------
37
HHSearch
78.18
19%
-142
- C1 -
2KS9
1
NK1R_HUMAN
A:
[35-326]
--------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
--
V
V
N
F
T
Y
A
V
-
H
----
N
E
W
YYG
L
F
Y
-----
C
K
F
H
N
F
F
P
I
A
A
--------
V
-------------
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-
Y
--
Y
S
---------
T
T
ET
M
-----
P
-
S
--
R
------
V
V
C
M
I
-------
E
W
P
---
E
----
H
PNKIY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
----
W
A
S
E
I
P
G
--
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------
D
--------------
R
Y
H
E
Q
V
S
A
K
R
-----
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
-
L
P
Y
I
N
P
---
D
LYLK
K
F
I
Q
Q
--
V
Y
L
A
I
M
W
---
L
A
M
S
-
S
T
M
Y
---
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
---