@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LPAR2_HUMAN: (2016-01-10 )
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
Atome Classification :
(20 SA)
.........10........20........30........40......---..50........60........70........80.....-...90....--.---...100........110.-.....-.120.......130...-....140----....-....150.......160...--------------..-..170-----.-..------...--.-------180-------------.........-190.......200........210.......220.....-------------------------------------------------------------------------------------------------------------------------------------------------------..230.......240-.........250.......260.......270........280-.--.......290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
I
M
G
Q
C
Y
Y
N
E
T
I
G
F
F
YNNSGK
E
L
S
SHWRP
K
D
V
V
V
V
A
L
G
L
T
V
S
V
L
V
L
---
L
T
N
L
L
V
I
A
A
IASNRRFHQ
P
I
Y
Y
L
L
G
N
L
A
A
A
D
L
F
A
G
V
A
Y
L
-
F
L
M
FHTGP
R
--
T
---
A
R
L
S
-L
E
G
W
F
L
RQGLLD
T
-
S
L
T
A
S
-
V
A
T
L
L
A
I
A
V
E
RHR
S
V
M
A
-
V
Q
L
H
S-R----LPRG-
R
V
V
M
L
I
V
G
V
W
V
A
A
L
G
L
GLLP--------------AH-S
W
H
C
L
-----
C
-
A
L
------
D
R
C
--
S
-------
R
---------------
M
A
P
L
L
S
R
S
Y
-
L
A
V
W
A
L
S
S
L
L
V
-
F
L
L
M
V
A
V
Y
T
R
I
F
F
Y
V
R
R
R
V
Q
R
M
A
E
HVS-------------------------------------------------------------------------------------------------------------------------------------------------------CHP
R
Y
R
E
T
T
L
S
L
V
---
K
T
V
V
I
I
L
G
A
F
V
V
C
WTP
G
Q
V
V
L
L
L
DGLGCES-C
N
V
L
A
V
E
K
Y
F
L
--
L
--
L
AE
A
N
S
L
V
N
A
A
V
YSCR
D
A
E
M
R
R
T
F
R
R
L
L
C
C
A
C
L
R
Q
STRE
S
V
H
YTSSAQGGA
S
T
R
I
M
LPENGHPLMDSTL
46
HHSearch
86.19
34%
-145
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[57-495]
-------------------------
A
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
---
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
T
-
A
N
L
L
L
S
G
A
T
--
T
---
Y
K
L
T
-
P
A
Q
W
F
L
R
E
G
S
M
F
V
-
A
L
S
A
S
-
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-------------
N
N
F
-
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
--------------
I
M
-
G
W
N
C
I
-----
S
-
A
L
------
S
S
C
--
S
-------
T
---------------
V
L
P
L
Y
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
-
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
A
S
R
S
S
E
N
V
A
L
L
---
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
C
D
I
L
F
R
A
E
Y
F
L
--
V
--
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-------------------------------------
10
PsiBlast_PDB
76.96
29%
-138
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[8-311]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
A
I
S
--
T
---
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
-
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
MLGWNNCGQPKEGK
A
----
G
C
G
-----
E
-
G
Q
------
V
A
C
LF
E
-------
D
---------------
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
-
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
-------------------------
7
PsiBlast_PDB
76.63
29%
-140
- C2 -
2YDO
3
?
A:
[8-311]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
A
I
S
--
T
---
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
-
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
MLGWNNCGQPK
E
G
K
A
H
-
S
Q
G
C
G
-----
E
-
G
Q
------
V
A
C
LF
E
-------
D
---------------
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
--------------------
56
HHSearch
76.35
23%
-135
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
-
P
F
G
A
A
H
I
L
M
K-
M
---
W
T
F
G
-
N
F
W
C
E
F
W
T
S
I
D
V
L
-
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-
P
F
K
Y
Q
S
L
----
L
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--------------
I
Q
M
H
W
Y
R
A
TH---
Q
-
E
A
I
N
C
Y
A
E
E
T
C
--
C
-------
D
---------------
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
K
F
C
L
K
E
H
K
A
L
---
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
--
W
--
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------
9
PsiBlast_PDB
76.30
29%
-139
- C2 -
4UG2
3
?
A:
[8-309]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
A
I
S
--
T
---
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
-
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
MLGWNNCGQPK
E
G
K
A
H
-
S
Q
G
C
G
-----
E
-
G
Q
------
V
A
C
LF
E
-------
D
---------------
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------
8
PsiBlast_PDB
76.23
29%
-139
- C2 -
2YDV
6
?
A:
[8-311]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
A
I
S
--
T
---
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
-
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
MLGWNNCGQPK
E
G
K
A
H
-
S
Q
G
C
G
-----
E
-
G
Q
------
V
A
C
LF
E
-------
D
---------------
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
-------------------
18
PsiBlast_PDB
76.05
27%
-143
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[8-305]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
------
P
-------------GCGEGQVACL
F
E
D
--
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
3
PsiBlast_PDB
75.92
56%
-156
- C2 -
4Z36
2
C562_ECOLX (first)
A:
[41-250]
-----
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
---
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
F
-
Y
L
M
F
N
T
G
P
N
--
T
---
R
R
L
T
-
V
S
T
W
L
L
R
Q
G
L
I
D
T
-
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
F
R
-
M
Q
L
H
T
-
R
----
M
S
N
R
-
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
--------------
S
V
-
G
W
N
C
I
-----
C
-
D
I
------
E
N
C
--
S
-------
N
---------------
M
A
P
L
Y
S
C
S
Y
-
L
V
F
W
A
I
F
N
L
V
T
-
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
G
M
K
D
F
R
H
G
F
D
I
L
V
-
G
Q
I
D
D
A
L
K
L
A
N
--
E
--
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
C
C
C
P
Q
C
D
V
L
A
17
PsiBlast_PDB
75.53
27%
-144
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[8-305]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
------
P
-------------GCGEGQVACL
F
E
D
--
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
14
PsiBlast_PDB
75.47
27%
-141
- C2 -
3PWH
1
?
A:
[8-305]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
------
P
-------------GCGEGQVACLFED--
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
15
PsiBlast_PDB
75.42
27%
-143
- C2 -
3REY
1
AA2AR_HUMAN
A:
[8-305]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
------
P
-------------GCGEGQVACL
F
E
D
--
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
52
HHSearch
75.27
24%
-140
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-472]
------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
-
P
F
A
I
T
I
S
T
G
------
F
C
A
A
-
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
----
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
C
-----
G
Q-
S
------
Q
G
C
--
G
EGQVACL
F
---------------
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
R
S
T
L
Q
K
E
V
H
A
A
---
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
--
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
16
PsiBlast_PDB
75.03
27%
-140
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[8-305]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
------
P
-------------GCGEGQVACL
F
E
D
--
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
54
HHSearch
74.95
22%
-135
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
---
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
-
P
W
V
V
Y
L
E
V
T
GG
V
---
W
N
F
S
-
R
I
C
C
D
V
F
V
T
L
D
V
M
-
M
C
T
A
S
-
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-
P
V
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
-
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
--------------
L
F
-
G
F
N
T
T
-----
G
-
D
P
------
T
V
C
--
S
-------
I
---------------
S
N
P
D
---
F
V
-
I
Y
S
S
V
V
S
F
Y
L
P
-
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
G
V
P
L
R
E
K
K
A
T
---
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
S
P
E
L
Y
S
A
T
T
--
W
--
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------
2
PsiBlast_PDB
74.77
56%
-155
- C2 -
4Z35
2
?
A:
[41-250]
-----
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
---
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
F
-
Y
L
M
F
N
T
G
P
N
--
T
---
R
R
L
T
-
V
S
T
W
L
L
R
Q
G
L
I
D
T
-
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
F
R
-
M
Q
L
H
T
-
R
----
M
S
N
R
-
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
--------------
S
V
-
G
W
N
C
I
-----
C
-
D
I
------
E
N
C
--
S
-------
N
---------------
M
A
P
L
Y
S
D
S
Y
-
L
V
F
W
A
I
F
N
L
V
T
-
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
M
K
D
F
R
H
G
F
D
I
L
V
-
G
Q
I
D
D
A
L
K
L
A
N
--
E
--
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
V
C
C
P
Q
C
D
V
L
A
20
PsiBlast_PDB
74.60
27%
-146
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[8-308]
---------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
--
L
-
A
I
P
F
A
I
T
I
S
--
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
-
G
----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------------
M
L
-
G
W
N
N
------
C
-
G
Q
--------------------SQGCGEGQ
V
A
C
L
F
ED
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
-
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
-
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
------------------------------------
48
HHSearch
74.42
22%
-129
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
---
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
-
N
L
Y
T
L
Y
T
V
I
G-
Y
---
W
P
L
G
-
P
V
V
C
D
L
W
L
A
L
D
Y
V
-
V
S
N
A
S
-
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-
P
L
T
Y
P
V
K
----
R
T
T
K
-
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
--------------
I
L
-
F
W
Q
F
I
V
GVRT
V
-
E
D
------
G
E
C
--
Y
-------
I
---------------
Q
F
F
S
N
A
A
V
T
-
F
G
T
A
I
A
A
F
Y
L
P
-
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
P
P
P
S
R
E
K
K
V
T
---
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
--
I
P
N
T
V
W
T
I
G
Y
--
W
--
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------
6
PsiBlast_PDB
74.26
28%
-148
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[1-286]
------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
--
T
---
W
T
F
G
--
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
-
L
----
L
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HWYRA------
T
H
-
Q
E
A
I
N
-----
C
Y
A
E
------
E
T
C
--
C
-------
D
---------------
F
--
F
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
I
D
K
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
K
E
H
K
A
-----
L
---
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
-
D
N
L
I
R
K
E
V
Y
I
L
--
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
------------------------------------
1
PsiBlast_PDB
74.12
56%
-154
- C2 -
4Z34
2
C562_ECOLX (first)
A:
[41-250]
-----
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
---
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
F
-
Y
L
M
F
N
T
G
P
N
--
T
---
R
R
L
T
-
V
S
T
W
L
L
R
Q
G
L
I
D
T
-
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
F
R
-
M
Q
L
H
T
-
R
----
M
S
N
R
-
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
--------------
S
V
-
G
W
N
C
I
-----
C
-
D
I
------
E
N
C
--
S
-------
N
---------------
M
A
P
L
Y
S
D
S
Y
-
L
V
F
W
A
I
F
N
L
V
T
-
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
M
K
D
F
R
H
G
F
D
I
L
V
-
G
Q
I
D
D
A
L
K
L
A
N
--
E
--
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
V
C
C
P
Q
C
D
V
L
A
12
PsiBlast_PDB
73.94
28%
-169
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[178-463]
------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
--
T
WTF
G
N
F
W
-
C
E
F
W
T
S
I
D
V
L
----
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
-
L
----
L
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HWYRA------
T
H
-
Q
E
A
I
N
-----
C
Y
A
E
------
E
T
C
--
C
-------
D
---------------
F
--
F
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
K
A
L
---
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
-
D
N
L
I
R
K
E
V
Y
I
L
--
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
------------------------------------