@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MTR1B_HUMAN: (2016-01-11 )
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
Atome Classification :
(20 SA)
.........10........20........30...----.----....-40........50.-----.......60........70........80........90..-......100-.......110.......120.......130.......140.......150--........160..----....-.170..-----.....180-..---.-..--.------..-------190-------.--------....------.----..-200---.........210.......220.......230.---....--------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------------------------------------.240.......---------250.-......-260.......270.......280.......290-----.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSENGS
F
A
N
C
C
EAGG
W
A
VRPGWSGAGSARPSRTP----R----PP
W
V
-
A
P
A
L
S
A
V
L
I
V
T
T
A
-----
V
D
V
V
G
N
L
L
V
I
L
S
V
L
RNRKLRNAG
N
L
F
L
V
S
L
A
L
A
D
L
V
V
A
FYP-
Y
P
L
I
L
V
A
I
F-YDGWAL
G
E
E
H
C
K
A
S
A
F
V
M
G
L
S
V
I
G
S
V
F
N
I
T
A
I
A
I
N
R
Y
C
Y
I
C
H
S
M
A
Y
H
R
I
---
Y
R
R
WH
T
P
L
H
I
C
L
I
----
W
L
L
T
-
V
V
A
L
L
P
-----
N
F
FVGS-L-EY---D-
P
R
--
I
------
Y
S
-------
C
T
--------
F
--------
I
QTA------S----TQ-
Y
-----
T
A
A
V
V
V
I
H
F
L
L
P
I
A
V
V
S
F
C
Y
L
R
I
W
V
L
V
L
Q
A
R
RK---AKPE--------------------------------------------------------------------------------------------------------------------------------------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
CL
K
P
S
D
L
R
S
---------
F
L
T
M
-
F
V
V
F
V
I
-
F
A
I
C
W
A
P
L
N
C
I
G
L
A
V
A
I
N
P
Q
E
MAPQIPE
G
L
F
V
T
-----
S
Y
L
L
A
Y
F
N
S
C
L
N
A
I
V
Y
G
L
L
N
Q
N
F
R
R
E
Y
K
R
I
L
L
A
LW
N
P
R
H
C
I
QDASKGSHAEGLQSPAP
P
I
I
G
V
QHQADAL
25
HHSearch
89.48
25%
-149
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------------------
L
V
V
V
L
S
T
I
C
L
-----
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
----
W
F
L
S
-
F
L
W
V
I
P
-----
I
L
G
W
N
H
----------
R
R
--
E
------
D
K
-------
C
E
--------
T
--------
D
F
Y
D
------
V
----
T
W
-
F
-----
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
---
F
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
H
M
N
R
E
R
K
A
---------
A
K
Q
L
-
G
F
I
M
A
A
-
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
----
C
N
E
H
L
H
M
F
-----
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------
24
HHSearch
88.26
20%
-157
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
-----
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
----
W
I
V
S
-
G
L
T
S
F
L
-----
P
I
Q
M
H
W
-
Y
-
R
A
---
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
-------
C
C
--------
D
--------
F
F
-
T
------
N
----
Q
A
-
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
---
F
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
K
F
C
L
K
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
T
-
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
-----
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------
32
HHSearch
87.97
25%
-160
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
-----
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
----
W
V
L
A
-
F
A
V
S
C
P
-----
L
L
F
G
F
N
-
T
------
T
-
G
D
--
P
------
T
V
-------
C
S
--------
I
--------
S
N
P
-------------
D
-
F
-----
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
---
N
I
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
V
P
L
R
E
K
K
A
---------
T
Q
M
V
-
A
I
V
L
G
A
-
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
-----
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------
28
HHSearch
86.88
22%
-151
- C1 -
3EML
13
ENLYS_BPT4
A:
[20-472]
----------------------------------------------
G
-
S
S
V
Y
I
T
V
E
L
A
I
A
V
-----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
----
W
V
L
S
-
F
A
I
G
L
T
-----
P
M
L
G
W
N
-
N
C
G
Q
---------
S
------
Q
G
CGEGQVA
C
L
--------
F
--------
E
D
V
V
------
P
----
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
---
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
S
T
L
Q
K
E
V
H
A
---------
A
K
S
L
-
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
-----
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------------
23
HHSearch
85.57
23%
-151
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
-----
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
----
W
V
L
S
-
F
I
L
W
A
P
-----
A
I
L
F
W
Q
-
F
-
I
V
GVR
T
-
V
E
--
D
------
G
E
-------
C
Y
--------
I
--------
Q
F
F
S
------
N
----
A
A
-
V
-----
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
---
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
P
P
P
S
R
E
K
K
V
---------
T
R
T
I
-
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
----
I
P
N
T
V
W
T
I
-----
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------
42
Fugue
84.69
20%
-127
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
QYYL
A
----
E
P
W
Q
-
F
S
M
L
A
A
Y
M
F
L
L
I
M
-----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
----
W
V
M
A
-
L
A
C
A
A
P
-----
P
L
V
-
G
W
-
S
-
R
Y
---
I
-
P
E
GM
Q
------
C
S
-------
C
G
I
DY-----
Y
--------
T
P
H
E
------
E
TN
N
-
E
S
-
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
A
---
A
A
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
Q
K
A
E
K
E
V
---------
T
R
M
V
-
I
I
M
V
I
A
-
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
F
G
P
I
F
M
T
I
-----
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------
16
PsiBlast_PDB
83.81
26%
-177
- C1 -
4MQT
2
ACM2_HUMAN
A:
[36-333]
-------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
----
W
V
L
S
-
F
I
L
W
A
P
AILF
W
Q
F
I
V
G
V
-
R
-
T
V
---
E
-
D
G
--
E
------
C
Y
-------
I
Q
--------
F
--------
F
S
N
A
------
A
----
V
T
-
F
-----
G
T
A
I
A
A
--
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSRE
K
K
V
--
T
R
T
I
-
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
M
---
V
L
I
N
-
T
F
C
A
P
C
I
P
N
T
V
W
T
I
-----
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
C
-------------------------------------
14
PsiBlast_PDB
82.76
26%
-169
- C1 -
5C1M
7
?
A:
[1-294]
-----------------------
G
S
H
S
L
-
P
-
Q
T
G
----
S
----
P
S
M
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
-----
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
-
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
-------
A
L
D
F
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
-
S
A
I
G
L
P
-----
V
M
F
M
A
T
-
T
-
K
Y
---
R
-
Q
G
--
S
------
I
D
-------
C
T
--------
L
--------
T
F
S
H
------
P
----
T
W
-
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
-
G
L
M
I
L
R
L
K
S
V
R
M
---
L
S
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
D
R
N
L
R
R
---------
I
T
R
M
V
L
V
V
V
A
V
-
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
------
I
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-------------------------------------------
15
PsiBlast_PDB
82.40
26%
-173
- C1 -
4MQS
1
?
A:
[36-333]
-------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
----
W
V
L
S
-
F
I
L
W
A
P
AILF
W
Q
F
I
V
G
V
-
R
-
T
V
---
E
-
D
G
--
E
------
C
Y
-------
I
Q
--------
F
--------
F
S
N
A
------
A
----
V
T
-
F
-----
G
T
A
I
A
A
--
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPPS
R
E
K
K
V
T
R
T
I
-
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
M
---
V
L
I
N
-
T
F
C
A
P
C
I
P
N
T
V
W
T
I
-----
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------
43
Fugue
82.19
21%
-114
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
----
Q
YYLA
E
P
W
Q
-
F
S
M
L
A
A
Y
M
F
L
L
I
M
-----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
----
W
V
M
A
-
L
A
C
A
A
P
-----
P
L
V
-
G
W
-
S
-
R
Y
---
I
-
P
E
--
G
------
M
Q
-------
C
S
--------
C
G
I
DYYTPH
E
E
T
N
------
N
----
E
S
-
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
---
A
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
---------
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
F
G
P
I
F
M
T
I
-----
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------
12
PsiBlast_PDB
82.06
26%
-155
- C1 -
4BVN
11
ADRB1_MELGA
A:
[13-299]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
DPGC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----
K
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
K
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------
11
PsiBlast_PDB
81.87
26%
-162
- C1 -
2YCY
6
ADRB1_MELGA
A:
[13-297]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
DPGC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-DR-
A
S
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-
R
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------
20
PsiBlast_PDB
81.78
22%
-139
- C1 -
1F88
7
OPSD_BOVIN
A:
[34-344]
--------------------------------------------
P
W
Q
-
F
S
M
L
A
A
Y
M
F
L
L
I
M
-----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
----
W
V
M
A
-
L
A
C
A
A
P
-----
P
-
L
V
G
W
-
S
-
R
Y
---
I
-
P
E
--
G
------
M
Q
-------
C
S
C
G
I
DYYTP
H
--------
E
E
T
N
------
N
----
E
S
-
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
---
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
---------
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
-----
A
F
-
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------
6
PsiBlast_PDB
81.32
26%
-162
- C1 -
3ZPR
11
ADRB1_MELGA
A:
[13-299]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
DPGC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
R
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
---------------------------------------
30
HHSearch
81.08
25%
-143
- C1 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
-----
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
----
W
V
L
A
-
L
L
L
A
F
P
-----
Q
G
Y
Y
S
T
-
T
-
E
T
---
M
-
P
S
--
R
------
V
V
-------
C
M
--------
I
--------
E
W
P
E
HPNKIY
E
----
K
V
-
Y
-----
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
---
G
D
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
R--------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
---------
V
K
M
M
-
I
V
V
V
C
T
-
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
-----
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
18
PsiBlast_PDB
81.05
22%
-157
- C1 -
3CAP
7
OPSD_BOVIN
A:
[34-326]
--------------------------------------------
P
W
Q
-
F
S
M
L
A
A
Y
M
F
L
L
I
M
-----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
----
W
V
M
A
-
L
A
C
A
A
P
-----
P
-
L
V
G
W
-
S
-
R
Y
---
I
-
P
E
--
G
------
M
Q
-------
C
S
CGIDYYTP
H
--------
E
E
T
N
------
N
----
E
S
-
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
---
A
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
---------
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
-----
A
F
-
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------------------
8
PsiBlast_PDB
80.82
26%
-158
- C1 -
2YCW
7
ADRB1_MELGA
A:
[13-297]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
D
P
GC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
IDR
A
S
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-
R
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------
33
HHSearch
80.22
20%
-152
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-334]
---------------------------------------------
A
V
-
Y
Y
S
L
G
I
F
I
G
I
C
G
I
-----
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
----
W
L
W
S
-
V
L
W
A
I
G
-----
P
I
F
G
W
G
A
Y
-
T
L
---
E
-
G
V
--
L
------
C
N
-------
C
S
--------
F
--------
D
Y
I
S
------
R
D
S
T
T
R
S
-
N
-----
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
---
M
A
A
M
A
K
RLNAKE
L
R
----------------------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
G
A
N
A
E
M
R
L
---------
A
K
I
S
-
I
V
I
V
S
Q
-
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
---
W
V
T
P
Y
A
A
Q
L
-----
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------
7
PsiBlast_PDB
80.14
26%
-165
- C1 -
2VT4
8
ADRB1_MELGA
A:
[13-297]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
DPGC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------
4
PsiBlast_PDB
80.13
26%
-165
- C1 -
2Y03
9
ADRB1_MELGA
A:
[13-299]
--------------------------------------------------
G
M
S
L
L
M
A
L
V
V
L
-----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
----
W
A
I
S
A
L
V
S
F
L
P
-----
I
M
M
H
W
W
-
R
-
D
E
---
D
-
P
Q
--
A
------
L
K
C
Y
Q
DPGC
C
D
--------
F
--------
V
T
N
R
------
A
-------
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
---------
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
----
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------