@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52K2_HUMAN: (2016-01-12 )
MSASNITLTHPTAFLLVGIPGLEHLHIWISIPFCLAYTLALLGNCTLLLIIQADAALHEPMYLFLAMLAAIDLVLSSSALPKMLAIFWFRDREINFFACLAQMFFLHSFSIMESAVLLAMAFDRYVAICKPLHYTKVLTGSLITKIGMAAVARAVTLMTPLPFLLRCFHYCRGPVIAHCYCEHMAVVRLACGDTSFNNIYGIAVAMFIVVLDLLLVILSYIFILQAVLLLASQEARYKAFGTCVSHIGAILAFYTTVVISSVMHRVARHAAPHVHILLANFYLLFPPMVNPIIYGVKTKQIRESILGVFPRKDM
Atome Classification :
(20 SA)
------------.......-..10........20-------.....------....30........40........50-........60........-70......-----..-80........90..-.--.....100.....----..110----....--...120.......130-------.......-----.140.......150...---------------....160------------...-....-----.170-----------..--......180.......190..-..-.-..-.---.200....--...210..--.....220-..-----.---------------------......230-----------.------------..------------------------------------------------------------------------------------------------------------------------------------------------------------------......240.......250.---......260......-.----------270.--....----....280.......290.....--..300........310..----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MSAS
N
I
T
-
L
THP
T
A
F
L
L
V
GIP--------G
L
E
H
L
------
H
I
W
I
S
I
P
F
C
L
A
Y
T
L
A
L
LGN
C
T
L
L
L
I
I
-QAD
A
A
LH
E
P
M
Y
L
F
L
A
M
L
A
-
A
I
D
L
V
LSS-----S
A
-
L
P
K
M
L
A
I
F
W
F
RDRE-
I
--
N
F
F
A
C
L
A
Q
M
F
F
L
H
----
S
F
S
I
M
----
E
S
A
V
--
L
L
A
M
A
F
D
R
Y
V
A
I
CKP--------
L
H
Y
T
K
V
L
-----
T
G
S
L
I
T
K
I
G
M
A
A
V
A
R
A
V
---------------
T
LMT
P
L
-------------
P
F
L
-
L
R
C
F
-----
H
Y
C------------RG--P
V
I
A
H
C
Y
C
E
H
M
A
V
V
RLA--CG-DT-S-F
N
-
N
---
I
Y
G
I
A
V
A
M
--
F
I
V
V
L
D
L
L
--
L
V
I
L
S
Y
---
I
F
-----
I
---------------------
L
Q
A
V
L
L
L-------------A------------SQ------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
Y
K
A
F
G
T
C
V
S
H
I
G
A
I
L
A
F
---
Y
T
T
V
V
I
S
S
V
M
H
R
V
A
R
-H----------A--A--
P
H
V
H
----
I
L
LA
N
F
Y
LLFPPM
V
N
P
I
I
YGV
K
--
T
K
Q
I
-
R
E
S
I
L
GVFPRKDM----------------------
26
HHSearch
91.25
20%
-168
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-469]
-----------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
-
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
----
V
L
T
Q
S
----
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
--------
L
R
Y
N
G
L
V
-----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---------------
A
I
G
L
T
P
-------------
M
L
G
-
W
N
N
C
-----
G
Q
---------------------
S
Q
G
C
G
E
G
Q
V
---
A
--
C
L
-
F
E
-
D
V
V
P
M
N
---
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
---
L
R
-----
I
---------------------
F
L
A
A
R
R
Q
-------------
L
------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
---
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
CS--------
H
--
A
--
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
--
I
R
E
F
-
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
27
HHSearch
89.46
17%
-161
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
-
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
-
F
A
E
A
S
M
A
A
-----
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
-
Y
--
G
L
F
Y
C
K
F
H
N
F
F
P
I
----
A
A
V
F
A
----
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
--------
L
Q
P
R
L
-------
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
---------------
L
L
A
F
P
Q
-------------
G
Y
Y
-
S
T
T
E
-----
T
-------------------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
-----
P
-
N
K
-
I
-
Y
E
-
K
---
V
Y
H
I
C
V
T
V
--
L
I
Y
F
L
P
L
L
--
V
I
G
Y
A
Y
---
T
V
-----
V
---------------------
G
I
T
L
W
A
S
-------------
E
------------
I
P
GDSSDRYH
E
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
---
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
-
D
----------
L
YL
K
KF
I
Q
Q
V
----
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
--
N
D
R
F
-
R
L
G
F
K
H
A
F
R
C
C
P
F
----------------------
22
HHSearch
88.22
15%
-160
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
-------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
-
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
-
V
A
D
L
I
V
G
A
-----
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
-
L
--
G
R
P
L
C
L
F
W
L
S
M
D
Y
----
V
A
S
T
A
----
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
--------
L
R
Y
L
K
Y
R
-----
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
---------------
L
W
V
I
P
I
-------------
L
G
W
--
N
H
---------------------------
R
R
E
D
K
C
E
T
D
F
Y
D
--------------
V
-
T
---
W
F
K
V
M
T
A
I
--
I
N
F
Y
L
P
T
L
--
L
M
L
W
F
Y
---
A
K
-----
I
---------------------
Y
K
A
V
R
Q
H
-------------
C
------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM-
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
---
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
-
N
----------
C
--
C
--
N
E
H
L
----
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
--
N
E
N
F
-
K
K
T
F
K
R
I
L
H
I
-------------------------
39
Fugue
87.62
16%
-155
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
-
V
R
S
P
F
E
A
P
Q
Y
Y
L
---------
A
E
P
W
Q
------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-----
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
-
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
----
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--------
M
S
N
F
R
F
G
-----
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
---------------
C
A
A
P
P
L
-------------
V
G
W
-
S
R
-------
Y
I
P
------------
E
G
---------------
M
Q
C
S
--
C
G
I
D
Y
Y
T
-
P
H
-
E
---
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
---
I
F
-----
F
---------------------
C
Y
G
Q
L
V
F
-------------
T
VKEAAASATTQK
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
-
S
----------
D
--
F
--
G
P
I
F
----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
--
N
K
Q
F
-
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A------
17
PsiBlast_PDB
87.07
24%
-175
- C4 -
4QKX
2
ADRB2_HUMAN
A:
[197-447]
-------------------------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
T
-
F
--
G
N
F
W
C
E
----
F
W
T
----
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
L
-----
T
K
N
---------
K
A
R
V
I
---------------
I
L
M
V
W
I
-------------
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
W
Y
------------
R
A
TH
Q
E
A
I
N
C
Y
A
E
E
------
T
--
C
C
-
D
F
-
F
-
T
N
-
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
---
V
F
Q
E
A
K
R
Q
---------------------
L
Q
---
K
F
-------------
A
------------
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
---
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L---------
I
--
R
--
K
E
V
Y
----
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
--
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------------
32
HHSearch
86.51
16%
-161
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-332]
--------------------------------------------
A
V
------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
-
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
-
F
S
D
F
T
F
S
L
-----
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
-
F
--
G
F
A
A
C
K
V
Y
G
F
I
G
G
----
I
F
G
F
M
----
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
--------
M
A
A
S
K
K
M
-----
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
---------------
L
W
A
I
G
P
-------------
I
F
G
-
W
G
A
Y
-----
T
L
------------------
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------
R
D
-
S
-
T
T
-
R
---
S
N
I
L
C
M
F
I
--
L
G
F
F
G
P
I
L
--
I
I
F
F
C
Y
---
F
N
-----
I
---------------------
V
M
S
V
S
N
H
-------------
E
------------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
---
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
E---------
W
--
V
--
T
P
Y
A
----
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
--
H
P
K
F
-
R
E
A
I
S
Q
T
F
P
W
V
L
T
----------------------
18
PsiBlast_PDB
85.70
24%
-173
- C4 -
4LDE
3
A:
[197-447]
-------------------------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
--
G
N
F
W
C
E
----
F
W
T
----
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
L
-----
T
K
N
---------
K
A
R
V
I
---------------
I
L
M
V
W
I
-------------
V
S
G
-
L
T
S
F
LPIQM
H
W
Y
------------
R
A
TH
Q
E
A
I
N
C
Y
A
E
E
------
T
--
C
C
-
D
F
-
F
-
T
N
-
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
---
V
F
Q
E
A
K
R
Q
---------------------
L
Q
---
K
F
-------------
A
------------
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
---
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L---------
I
--
R
--
K
E
V
Y
----
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
--
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------------
19
PsiBlast_PDB
85.62
24%
-171
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[197-447]
-------------------------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
--
G
N
F
W
C
E
----
F
W
T
----
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
L
-----
T
K
N
---------
K
A
R
V
I
---------------
I
L
M
V
W
I
-------------
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
W
Y
------------
R
A
TH
Q
E
A
I
N
C
Y
A
E
E
------
T
--
C
C
-
D
F
-
F
-
T
N
-
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
---
V
F
Q
E
A
K
R
Q
---------------------
L
Q
---
K
F
-------------
A
------------
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
---
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L---------
I
--
R
--
K
E
V
Y
----
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
--
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------------
20
PsiBlast_PDB
85.47
24%
-171
- C4 -
4LDO
3
A:
[197-447]
-------------------------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
--
G
N
F
W
C
E
----
F
W
T
----
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
L
-----
T
K
N
---------
K
A
R
V
I
---------------
I
L
M
V
W
I
-------------
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
W
Y
------------
R
A
TH
Q
E
A
I
N
C
Y
A
E
E
------
T
--
C
C
-
D
F
-
F
-
T
N
-
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
---
V
F
Q
E
A
K
R
Q
---------------------
L
Q
---
K
F
-------------
A
------------
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
---
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L---------
I
--
R
--
K
E
V
Y
----
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
--
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------------
41
Fugue
85.03
17%
-151
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
-
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
--------
E
P
W
Q
F
------
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-----
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
-
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
----
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--------
M
S
N
F
R
F
G
-----
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
---------------
C
A
A
P
P
L
-------------
V
G
W
-
S
R
-------
Y
I
P
------------
E
G
---------------
M
Q
C
S
--
C
G
-
I
D
-
Y
-
Y
T
-
P
---
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
---
I
F
-----
F
---------------------
C
Y
G
Q
L
V
F
TVKEAAAQQQESA
T
------------
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
---
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
----------
D
--
F
--
G
P
I
F
----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
--
N
K
Q
F
-
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA
21
HHSearch
83.97
16%
-163
* C4 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
-
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
-
C
A
D
L
I
I
G
V
-----
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
-
L
--
G
P
V
V
C
D
L
W
L
A
L
D
Y
----
V
V
S
N
A
----
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
--------
L
T
Y
P
V
K
R
-----
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
---------------
I
L
W
A
P
A
-------------
I
L
F
-
W
Q
F
I
-----
V
G
V
------------
R
----
T
V
E
D
G
E
C
Y
I
Q
F
F
--------------
S
N
-
A
---
A
V
T
F
G
T
A
I
--
A
A
F
Y
L
P
V
I
--
I
M
T
V
L
Y
---
W
H
-----
I
---------------------
S
R
A
S
K
S
R
-------------
I
------------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP-
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
---
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
-
P
----------
C
--
I
--
P
N
T
V
----
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
--
N
A
T
F
-
K
K
T
F
K
H
L
L
M
--------------------------
45
Fugue
82.07
18%
-177
* C3 *
3ES5
-
?
A:
[42-420]
------------
M
R
L
G
W
I
D
P
L
P
Q
V
D
T
I
F
P
L
G
L
E
PNVESIPA
G
E
V
E
L
------
D
F
N
L
P
E
T
I
A
K
P
F
A
D
T
V
T
S
V
G
D
R
I
Q
L
V
-
D
D
D
K
E
N
I
A
T
S
I
Y
G
L
S
F
F
K
-
A
A
R
Q
L
Y
S
T
ML
D
H
E
K
A
-
V
N
Q
P
L
K
A
V
Y
Y
D
E
T
P
-
I
P
A
H
M
S
G
A
L
G
I
I
G
H
M
K
T
KVG
D
V
L
V
K
----
D
A
G
V
--
L
F
K
R
G
T
A
A
G
V
T
K
F
S
E
I
DNDKTWN
L
D
C
S
K
L
V
WAD
H
S
S
L
S
M
I
K
R
L
A
S
E
K
I
S
Q
L
V
K
Q
R
Y
R
V
T
D
AQGHVYS
V
S
M
P
Q
L
-------------
T
D
Q
-
A
L
P
D
-----
Y
Y
D
------------
S
I
--
P
D
V
A
P
-
N
S
D
Q
L
R
V
L
T
A
A
L
Q
M
S
-
L
A
-
Q
-
F
R
-
N
DEL
P
H
D
E
D
R
S
D
--
L
L
T
T
L
D
L
L
--
Y
A
D
G
A
Y
E
I
S
A
L
-----
R
---------------------
D
Q
F
E
L
L
M
-------------
A
------------
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
D
F
K
W
R
V
E
S
I
F
K
V
G
P
P
P
A
G
TTG
Y
G
A
Q
T
V
S
S
T
-
G
N
T
A
R
-
W
----------
Q
--
F
--
P
L
S
D
----
A
D
I
N
I
G
Y
L
F
S
P
S
K
S
F
S
L
F
P
K
M
V
G
Y
S
K
R
A
-
R
E
D
A
S
A
S
F
A
N
S
D
A
KKFYAD----------------
31
HHSearch
80.03
17%
-160
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------
L
N
------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
-
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
-
L
A
D
L
L
F
A
L
------
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
-
F
--
G
T
F
L
C
K
V
V
S
L
L
K
E
----
V
N
F
Y
S
----
G
I
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
--------
T
R
T
L
T
-
Q
-----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
---------------
N
L
S
L
P
F
-------------
F
L
F
-
R
Q
A
Y
-----
H
P
------------------
N
N
S
S
P
V
C
Y
E
V
L
G
N
------
D
-
T
A
-
K
-
W
R
-
M
---
V
L
R
I
L
P
H
T
--
F
G
F
I
V
P
L
F
--
V
M
L
F
C
Y
---
G
F
-----
T
---------------------
L
R
T
L
F
K
A
-------------
H
------------
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
---
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
-
T
QVIQE
S
C
E
R
R
N
--
N
--
I
G
R
A
----
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
--
G
Q
N
F
-
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------
30
HHSearch
79.61
16%
-148
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-326]
-----------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-----
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
-
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
----
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--------
M
S
N
F
R
F
------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---------------
A
C
A
A
P
P
-------------
L
V
G
-
W
S
R
Y
-----
I
P
------------------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
-----
H
-
E
E
-
T
-
N
N
-
E
---
S
F
V
I
Y
M
F
V
--
V
H
F
I
I
P
L
I
--
V
I
F
F
C
Y
---
G
Q
-----
L
---------------------
V
F
T
V
K
E
A
-------------
A
------------
A
Q
QQESA
T
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
---
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-
G
S---------
D
--
F
--
G
P
I
F
----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
--
N
K
Q
F
-
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
33
HHSearch
78.33
18%
-159
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
--------------------------------------------
N
S
------
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
-
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
-
L
S
D
L
L
A
G
V
-----
A
Y
-
T
A
N
L
L
L
S
G
A
-
T
T
Y
K
-
L
--
T
P
A
Q
W
F
L
R
E
G
S
M
F
----
V
A
L
S
A
----
S
V
F
S
--
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
---------------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
---------------
I
L
G
G
L
P
-------------
I
M
G
-
W
N
C
I
-----
S
---------------------
A
L
S
S
C
S
T
V
L
P
L
-------------
Y
H
-
K
---
H
Y
I
L
-
F
C
T
--
T
V
F
T
L
L
L
L
--
S
I
V
I
L
Y
---
C
R
-----
I
---------------------
Y
S
L
V
R
T
R
-------------
N
------------
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
-
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
---
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
-
V
----------
K
TC
D
--
I
L
F
R
----
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
--
N
K
E
M
-
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------
23
HHSearch
71.30
19%
-159
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
-----------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
-
F
--
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
----
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
L
-----
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
---------------
L
T
S
F
L
P
-------------
I
Q
M
H
W
Y
R
A
-----
T
H
Q
-------------------
E
A
I
N
C
Y
A
E
----
E
T
--
C
C
-
D
F
-
F
-
T
N
-
Q
---
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
--
I
M
V
F
V
Y
---
S
R
-----
V
---------------------
F
Q
E
A
K
R
Q
-------------
L
------------
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
---
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
-
L
----------
N
--
A
--
A
K
S
E
----
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--
N
Q
D
V
-
D
A
A
V
R
G
I
L
R
N
A
K
L
----------------------
42
Fugue
68.95
20%
-141
- C2 -
4RDQ
9
?
A:
[1-366]
----------------
T
V
T
-
Y
T
N
R
V
A
D
A
R
L
G
T
F
--------
S
Q
L
L
L
QWKGS
I
Y
K
L
L
Y
S
E
F
L
I
F
I
S
L
Y
F
A
I
S
L
V
Y
R
L
I
L
S
E
S
Q
R
L
M
F
E
K
L
A
L
Y
C
N
S
Y
A
E
L
I
P
V
S
F
V
L
-----
G
F
-
Y
V
S
L
V
V
S
R
W
W
A
Q
Y
E
S
I
--
P
W
P
D
R
I
M
N
L
V
S
C
N
----
V
D
G
E
D
----
E
Y
G
R
--
L
L
R
R
T
L
M
R
Y
S
N
L
C
S
V
--------
L
I
L
R
S
V
S
-----
T
A
V
Y
K
R
F
P
S
M
E
H
V
V
R
A
----------------
G
L
M
T
P
E
E
H
K
K
F
E
S
LNSPHN
K
F
W
-
I
P
C
V
-----
W
F
S
N
L
A
V
K
A
R
N
E
GRI
R
D
--
S
V
L
L
Q
G
I
L
N
E
L
N
T
L
R
S
Q
--
C
G
-
R
L
-
Y
-
G
Y
-
D
---
W
I
S
I
P
L
V
Y
--
T
Q
V
V
T
V
A
V
--
Y
S
F
F
L
A
---
C
L
-----
I
G
RQFLDPEKAYPGHELDLFVP
V
F
T
F
L
Q
F
-------------
F
------------
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
W
L
K
V
A
E
Q
L
I
N
P
F
G
E
D
D
D
D
---
F
E
T
N
W
L
I
D
R
N
L
Q
V
S
L
-
M
----------
A
--
V
--
D
E
M
H
QDLP
I
L
E
K
D
L
Y
W
N
E
P
D
P
Q
P
P
--
Y
T
A
A
--
T
A
E
Y
K
R
P
S
F
L
G
S
T
F
D
I
S
-----------------------
3
PsiBlast_PDB
65.44
25%
-174
- C4 -
4EIY
19
AA2AR_HUMAN (first)
A:
[24-191]
------------------------------
G
A
P
--------
P
I
M
G
S
------
S
V
Y
I
T
V
E
L
A
I
A
-
V
L
A
I
L
G
N
V
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
F
A
I
T
I
------
S
-
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
----
C
F
V
L
V
L
T
--
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
--------
L
R
Y
N
G
L
V
-----
T
G
T
R
A
K
--
G
I
I
A
I
C
W
V
L
---------------
S
F
A
I
G
L
-------------
T
P
M
-
L
G
-
W
-----
N
N
C
------------
G
Q
--
P
K
E
G
K
N
H
S
Q
G
C
G
E
G
Q
V
A
--
C
L
-
F
E
-
D
-
V
V
-
P
---
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
--
L
L
L
M
L
G
---
V
Y
-----
L
---------------------
R
I
F
L
A
A
R
-------------
R
------------
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
---
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
-
A
----------
A
--
L
--
D
A
Q
K
----
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
--
N
E
G
K
-
V
K
E
A
Q
A
A
A
E
Q
L
K
T
----------------------
44
Fugue
63.50
18%
-170
- C1 -
3W6S
2
?
A:
[19-243]
----------------
S
I
E
-
W
K
-
L
T
A
N
L
R
N
G
P
T
--------
F
F
Q
P
L
------
A
D
S
I
E
P
---
L
Q
F
K
L
I
G
S
D
T
V
A
T
A
F
P
V
-
F
D
T
K
Y
I
P
D
S
L
I
N
Y
L
F
K
L
F
-
N
L
E
I
E
S
G
K
-----
T
----------
Y
P
Q
L
H
S
-
L
--
T
K
Q
G
F
L
N
Y
W
F
H
S
F
----
A
V
V
V
L
----
Q
T
D
---------
E
K
F
I
Q
--
D
N
--------
Q
D
W
N
S
V
L
-----
L
G
T
F
Y
I
K
P
N
Y
A
--------------------------------------------
P
R
C
S
-----
H
N
C
------------
N
A
--
G
F
L
V
-------------------
N
-
G
-
A
H
-
R
---
G
Q
K
V
G
Y
R
L
--
A
Q
V
Y
L
N
W
A
--
P
L
L
G
Y
K
---
Y
S
-----
I
---------------------
F
N
L
V
F
V
---------------------------
T
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
S
W
K
I
W
D
K
--------
L
N
F
---
Q
R
I
G
L
V
P
---------------------------
H
A
G
----
I
L
N
G
-----
F
S
E
P
V
D
A
I
I
Y
G
K
D
--
L
T
K
I
-
E
P
E
F
L
S
M
E
---------------------------
1
PsiBlast_PDB
63.50
25%
-175
- C4 -
3EML
8
ENLYS_BPT4
A:
[18-181]
------------------------------------------
I
M
G
S
------
S
V
Y
I
T
V
E
L
A
I
A
-
V
L
A
I
L
G
N
V
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
F
A
I
T
I
------
S
-
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
----
C
F
V
L
V
L
T
--
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
--------
L
R
Y
N
G
L
V
-----
T
G
T
R
A
K
--
G
I
I
A
I
C
W
V
L
---------------
S
F
A
I
G
L
-------------
T
P
M
-
L
-
G
W
-----
N
N
C
------------
G
Q
---------
S
Q
G
C
G
E
G
Q
V
A
--
C
L
-
F
E
-
D
-
V
V
-
P
---
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
--
L
L
L
M
L
G
---
V
Y
-----
L
---------------------
R
I
F
L
A
A
R
-------------
R
------------
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
---
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
----------
S
--
L
--
N
A
A
K
----
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
--
L
F
N
Q
-
D
V
D
A
A
V
R
G
I
L
R
N
A
----------------------