@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2S1_HUMAN: (2016-01-13 )
MEKANETSPVMGFVLLRLSAHPELEKTFFVLILLMYLVILLGNGVLILVTILDSRLHTPMYFFLGNLSFLDICFTTSSVPLVLDSFLTPQETISFSACAVQMALSFAMAGTECLLLSMMAFDRYVAICNPLRYSVIMSKAAYMPMAASSWAIGGAASVVHTSLAIQLPFCGDNVINHFTCEILAVLKLACADISINVISMEVTNVIFLGVPVLFISFSYVFIITTILRIPSAEGRKKVFSTCSAHLTVVIVFYGTLFFMYGKPKSKDSMGADKEDLSDKLIPLFYGVVTPMLNPIIYSLRNKDVKAAVRRLLRPKGFTQ
Atome Classification :
(20 SA)
....---------.....10........20........30........40.---.......50........60........70.......-.80........90......--..100.......110.......120.......130.......140.......150.......160......-----.---170.......180.......190.......200.......210.....----..---------220---------.......230.-----------.-----------------..---------..-.240...---....250.......260.......270..-----..-...280..--.....290.......300.......310.----......----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKA---------NETS
P
V
M
G
F
V
L
L
RLSAHP
E
L
E
K
T
F
F
V
L
I
L
L
M
Y
L
V
I
L
LG---N
G
V
L
I
L
V
T
I
L
DSRLHT
P
M
Y
F
FLGN
L
S
F
L
D
I
C
FTTSS-
V
P
L
V
L
D
S
FL
T
P
Q
E
TI
S
F
S
A
--
C
A
V
Q
M
A
L
S
F
A
M
A
G
T
E
C
L
L
L
S
M
M
A
F
D
R
Y
V
A
I
C
N
P
L
R
Y
S
V
I
M
SKAAYMPMAASSWAIG
G
A
A
S
V
V
H
T
S
L
A
I
QLP-----F---CG
D
N
V
I
N
H
F
T
C
E
I
L
A
V
L
K
L
ACA
D
I
S
I
N
V
I
S
M
E
V
T
N
V
I
F
LG
V
P
V
L
F
I
S
F
----
S
Y
---------
V
F
I
---------
I
T
T
I
L
RIPSAE-----------
G
-----------------
R
K
---------
K
V
-
F
S
T
CSA
H
---
L
T
V
V
I
V
F
Y
G
T
L
F
F
MYGKPKSKDSMGA
D
K
E
-----
D
L-S
D
K
L
I
P
L
F
--
Y
G
V
V
T
P
M
L
N
P
I
I
Y
S
LRNK
D
V
K
A
A
V
R
R
L
LR----PKGFTQ----------------
12
PsiBlast_PDB
86.49
24%
-135
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
K
I
D
R
A
S
-----------
K
-----------------
R
K
---------
R
V
M
L
M
R
E
H
K
A
---
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----
F
---------------------
10
PsiBlast_PDB
86.30
24%
-134
- C3 -
2YCW
7
ADRB1_MELGA
A:
[9-297]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
K
I
D
R
A
S
-----------
K
-----------------
R
K
---------
R
V
M
L
M
R
E
H
K
A
---
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----
F
---------------------
13
PsiBlast_PDB
86.08
24%
-133
- C3 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
--------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
--
D
R
A
S
-----------
K
-----------------
R
K
---------
R
V
M
L
M
R
E
H
K
A
---
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----
F
---------------------
16
PsiBlast_PDB
85.26
23%
-144
- C3 -
2Y01
12
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
---------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
20
PsiBlast_PDB
84.91
23%
-144
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
---------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
11
PsiBlast_PDB
84.77
24%
-127
- C3 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
K
I
D
R
A
S
-----------
K
-----------------
R
K
---------
R
V
M
L
M
R
E
H
K
A
---
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------------
17
PsiBlast_PDB
84.75
23%
-146
- C3 -
2Y02
13
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
---------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
15
PsiBlast_PDB
84.64
23%
-145
- C3 -
2Y00
13
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
---------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
9
PsiBlast_PDB
83.77
24%
-141
- C3 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
--------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
----------------------------------------------------
E
H
K
A
---
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
19
PsiBlast_PDB
83.58
23%
-147
- C3 -
2Y04
13
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
---------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
18
PsiBlast_PDB
83.25
23%
-146
- C3 -
2Y03
9
ADRB1_MELGA
A:
[9-299]
-------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
--
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
----
L
P
I
M
M
H
-----
W
---
W
R
D
E
D
P
Q
A
L
K
C
----
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---------
R
E
A
---------
K
E
Q
I
R
-------------------------------------S
R
V
M
L
M
R
E
H
K
A
-
L
K
T
L
G
I
I
---
M
G
V
F
T
L
C
W
L
P
F
F
L
V
-------
N
I
V
N
V
F
N
R
-----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
5
PsiBlast_PDB
79.96
23%
-120
- C3 -
3PDS
4
ADRB2_HUMAN (first)
A:
[14-285]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
-----
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
---------
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
--
E
-----------
G
L----------------
R
L
---------
K
I
-
Y
K
D
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------
6
PsiBlast_PDB
79.94
23%
-120
- C3 -
2RH1
9
ADRB2_HUMAN (first)
A:
[45-316]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
-----
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
---------
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
--
E
-----------
G
L
----------------
R
L
---------
K
I
-
Y
K
D
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------
34
HHSearch
79.63
17%
-132
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-332]
---------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
--
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-----------
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
----
C
Y
---------
F
N
I
---------
V
M
S
V
S
N
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
---------
A
E
-
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
---
V
-----
T
P
-
Y
A
A
Q
L
P
V
M
--
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
----
W
V
L
T
C
C
----------------
28
HHSearch
79.20
16%
-130
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
--
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
-------
T
---
E
--
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
----
A
Y
---------
T
V
V
---------
G
I
T
L
W
A
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
-----------------
K
R
---------
K
V
-
V
K
M
M
I
V
V
---
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
Y
L
K
K
F
-----
I
Q
-
Q
V
Y
L
A
I
M
W
--
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
----
C
C
P
F
I
S
----------------
8
PsiBlast_PDB
77.99
23%
-108
- C3 -
4EJ4
1
ENLYS_BPT4 (first)
A:
[27-288]
----------------------------------------------
V
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
L
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
--
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
Q
P
-----
R
---
D
G
---------
A
V
V
C
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
----
C
Y
G
L
M
L
L
R
L
RS
V
R
N
---------
I
F
E
M
L
R
I
D
--
E
-----------
G
L----------------
R
L
---------
K
I
-
Y
K
N
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------
1
PsiBlast_PDB
77.75
23%
-126
- C3 -
3D4S
6
ENLYS_BPT4
A:
[46-317]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
-----
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
---------
S
R
V
F
Q
E
A
K
R
QLN
I
F
E
M
L
R
I
D
--
E
-----------
G
L----------------
R
L
---------
K
I
-
Y
K
D
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------
40
Fugue
77.41
19%
-94
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
---
C
G
---
I
D
Y
Y
T
P
H
----------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
---------
G
Q
L
---------
V
F
T
V
K
E
A
A
A
Q
Q
-----------
Q
-----------------
E
S
---------
A
T
-
T
Q
K
A
E
K
E
---
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGSDF
G
P
-
I
F
M
T
I
P
A
F
--
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKN
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
3
PsiBlast_PDB
77.02
23%
-120
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[46-317]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
-----
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
---------
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
--
E
-----------
G
L----------------
R
L
---------
K
I
-
Y
K
D
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------
4
PsiBlast_PDB
76.63
23%
-122
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[46-317]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
-----
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
---------
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
--
E
-----------
G
L----------------
R
L
---------
K
I
-
Y
K
D
T
E
G
Y
---
Y
T
I
-----
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
-----
E
L
-
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
P
----------------