@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5B3_HUMAN: (2016-01-13 )
MENKTEVTQFILLGLTNDSELQVPLFITFPFIYIITLVGNLGIIVLIFWDSCLHNPMYFFLSNLSLVDFCYSSAVTPIVMAGFLIEDKVISYNACAAQMYIFVAFATVENYLLASMAYDRYAAVCKPLHYTTTMTTTVCARLAIGSYLCGFLNASIHTGDTFSLSFCKSNEVHHFFCDIPAVMVLSCSDRHISELVLIYVVSFNIFIALLVILISYTFIFITILKMHSASVYQKPLSTCASHFIAVGIFYGTIIFMYLQPSSSHSMDTDKMAPVFYTMVIPMLNPLVYSLRNKEVKSAFKKVVEKAKLSVGWSV
Atome Classification :
(20 SA)
.........10......---------------..20...----------------.....30........40........50........60........70....-....80---........90......-..100-...-----.....110........120.......130.......140.......150.......160.....---..170......-.180.....-------.-------.190-.-...-...200....----...210.......220.-----------...------------...-----------230------------------.........240.......250..-------.....260----.---.---.--.--...270.......280.......290.......300.......310..----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
N
K
T
E
V
T
Q
F
I
L
L
GLTN---------------DSE
L
Q
V
P
----------------
L
F
I
T
F
P
F
I
Y
I
I
T
L
VGNL
G
I
I
V
L
I
F
W
D
S
C
LH
N
P
M
Y
F
F
L
SN
L
S
L
V
D
F
C
Y
SSA
V
-
T
P
I
V
M
A
---
G
F
L
IEDKVIS
Y
N
A
C
A
A
-
Q
M
Y
I
--
F
V
A
-----
F
A
T
V
E
N
-
Y
L
L
A
S
M
A
Y
D
R
Y
A
A
V
CKPLHYTT
T
M
T
T
T
V
C
A
R
L
A
I
G
S
Y
L
C
G
F
L
NASIHTGD
T
F
S
L
S
F
C---KSNE
V
H
H
F
FCD-I
P
A
V
M
V
L
SC-------S-------D
R
H
I
-
S
-
E
L
V
-
L
I
Y
V
V
S
F
N
I
F
----
I
A
L
L
V
I
L
I
S
Y
T
F
I
F
I
T
I
-----------
L
K
M------------HS
A
-----------
S
--------------------
V
Y
Q
K
P
L
S
T
C
A
S
H
F
I
A
V
G
I
F
Y
G
T
I
I
-------
F
M
Y
LQPSS----S---H---S--M--D
T
D
KM
A
P
V
F
Y
T
M
V
I
P
M
L
N
P
L
V
Y
S
L
R
N
K
E
V
K
S
A
F
K
K
V
V
E
K
AKLSVGWSV----------------
33
HHSearch
88.13
17%
-153
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-----------------------------------
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
---
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
F
I
--
G
G
I
-----
F
G
F
M
S
I
-
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
-------
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
-------------------
R
D
S
T
-
T
-
R
S
N
-
I
L
C
M
F
I
L
G
F
F
----
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
H
------------
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
-------
V
V
A
L
L
A
Q
F
----
G
PLE
W
---
V
--
T
--
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
----------------
9
PsiBlast_PDB
86.98
23%
-156
- C1 -
2YDV
6
?
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
--------
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP
K
E
G
K
A
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
ESQ-------------------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
----------------
8
PsiBlast_PDB
86.59
23%
-149
- C1 -
2YDO
3
?
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
--------
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP
K
E
G
K
A
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S-----------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
----------------
10
PsiBlast_PDB
84.93
23%
-153
- C1 -
4UG2
3
?
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
--------
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP
K
E
G
K
A
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L------------
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
31
HHSearch
84.65
18%
-145
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
--------------------------------------
L
----------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
---
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
-
H
N
F
F
--
P
I
A
-----
A
V
F
A
S
I
-
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
--------
M
P
S
R
V
V
C
M
-
I
E
W
P
E
H
P
-----------------
N
K
I
Y
-
E
-
K
V
Y
-
H
I
C
V
T
V
L
I
Y
F
----
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----------
W
A
S
------------
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
-------
I
F
F
L
L
P
Y
I
----
N
PD-
L
YL-
K
KF
I
--
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
----------------
2
PsiBlast_PDB
84.26
22%
-154
- C1 -
3REY
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
-----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP--------
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
7
PsiBlast_PDB
84.24
23%
-152
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQ-------
S
Q
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
11
PsiBlast_PDB
83.48
23%
-149
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
--------
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP
K
E
G
K
A
---
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--------
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
----------------
39
Fugue
82.64
17%
-125
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
--
A
T
L
-----
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------------
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
AASATTQ-----
K
A
E
-----------
K
--------------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
----
S
---
D
---
F
--
G
--
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A------
5
PsiBlast_PDB
82.60
22%
-153
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
-----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP--------
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
1
PsiBlast_PDB
82.60
22%
-152
- C1 -
3PWH
1
?
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
-----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP--------
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
3
PsiBlast_PDB
82.43
22%
-153
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
-----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP--------
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
6
PsiBlast_PDB
82.13
23%
-152
- C1 -
3VG9
8
?
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
-----
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
-
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQ-------
S
Q
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
4
PsiBlast_PDB
81.89
22%
-154
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[16-304]
--------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
-----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP--------
G
C
G
-
E
G
Q
V
A
C
L
--------------------
F
-
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
---
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
40
Fugue
77.31
16%
-111
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
--
A
T
L
-----
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
----------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
---
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
-
N
-
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
Q
------------
K
A
E
-----------
K
--------------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
----
S
---
D
---
F
--
G
--
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
30
HHSearch
73.87
15%
-124
- C1 -
1U19
14
OPSD_BOVIN
A:
[42-329]
--------------------------------------
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
--
A
T
L
-----
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
-
N
-
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
------------
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
-------
G
V
A
F
Y
I
F
T
H
---
Q
GS-
D
---
F
--
G
--
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
----------------
27
HHSearch
67.23
15%
-126
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
---------------------------------
T
L
N
K
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
---
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
-
V
S
L
L
--
K
E
V
-----
N
F
Y
S
G
I
-
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
-------
N
N
S
S
P
V
C
Y
-
E
V
L
G
N
-----------
D
-------
T
A
K
W
-
R
-
M
V
L
-
R
I
L
P
H
T
F
G
F
I
----
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----------
F
K
A
------------
H
M
------------
G
--------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
-------
L
V
L
L
A
D
T
L
M
RTQ
V
IQE
S
C
E
R
R
--
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------
23
HHSearch
64.10
19%
-145
* C1 *
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
-------------------------------------
V
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
---
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
--
D
V
L
-----
C
V
T
A
S
I
-
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-------
Q
E
A
I
N
C
Y
-
A
----
E
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
----
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
------------
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
----
P
---
S
---
L
--
N
--
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
----------------
26
HHSearch
60.75
17%
-155
- C1 -
3EML
8
ENLYS_BPT4
A:
[22-222]
-------------------------------------
S
V
----------------
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
--
T
G
F
C
A
A
C
H
G
C
L
F
-
I
A
C
F
--
V
L
V
-----
L
T
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
----------
S
Q
G
C
G
-
E
G
Q
---
V
A
C
-------
L
-------
F
E
D
V
V
P
M
N
Y
M
-
V
Y
F
N
F
F
A
C
V
L
----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
------------
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
----
P
---
S
---
L
--
N
--
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
----------------
22
HHSearch
59.67
18%
-149
- C1 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-201]
-------------------------------------
M
P
----------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
---
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
-
W
L
S
M
--
D
Y
V
-----
A
S
T
A
S
I
-
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
------------
R
R
E
D
K
-----------
C
-------
E
-------
T
D
F
Y
-
D
V
T
W
F
-
K
V
M
T
A
I
I
N
F
Y
----
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-----------
R
Q
H
------------
C
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
----
P
---
S
---
L
--
N
--
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
----------------