@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5BH_HUMAN: (2016-01-13 )
MENNTEVSEFILLGLTNAPELQVPLFIMFTLIYLITLTGNLGMIILILLDSHLHTPMYFFLSNLSLAGIGYSSAVTPKVLTGLLIEDKAISYSACAAQMFFCAVFATVENYLLSSMAYDRYAAVCNPLHYTTTMTTRVCACLAIGCYVIGFLNASIQIGDTFRLSFCMSNVIHHFFCDKPAVITLTCSEKHISELILVLISSFNVFFALLVTLISYLFILITILKRHTGKGYQKPLSTCGSHLIAIFLFYITVIIMYIRPSSSHSMDTDKIASVFYTMIIPMLSPIVYTLRNKDVKNAFMKVVEKAKYSLDSVF
Atome Classification :
(20 SA)
-----------------------------------------------.........10......---------------..20...----------------.....30........40.......---------.50.....----...60........70....-....80.......-..90..-----....--.----.100-.........110--.........120.......130...-....140.......150.......160.......-170......-.180-.......-------.-------.190.....-----...200-----.---......210..-----------.....220------..---.....230---------.--------------------......-------------..240.......250.-------.....-------.260.--.------------.------....270---------.........280.......290.......300.......310..------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------MENNT
E
V
S
E
F
I
L
L
GLTN---------------APELQ
V
P
----------------
L
F
I
M
F
T
L
I
Y
L
I
TLTGNL
G
M
I
I
L
I
L---------LDSHLH
T
P
----
M
Y
F
F
L
SNLSLAGIGYSSAV-
T
P
K
V
L
-
T
G
L
L
IED-KAI
S
Y
S
-----
A
C
A
A
--
Q
----
M
F
---
F
C
A
V
F
A
T
V
E
N
----
Y
L
L
S
S
M
A
Y
D
R
Y
A
A
V
CNPL
H
Y
T
T
T
M
T
-
T
R
V
C
A
C
L
A
I
G
C
Y
V
I
G
FLN
A
S
I
Q
IG
D
T
F
R
L
S
F
C
M
S
-
N
V
I
H
H
F
FCD-KP---
A
V
I
T
L
TC-------
S
-------
E
K
-
H
I
S
E
L
I
-----
L
V
L
I
S
S
-----
F
---
N
V
F
F
A
L
L
V
T
L
I
-----------
S
Y
L
F
I
L
I
T
------
I
L
---
K
R
HTGK-----------
G
--------------------
Y
Q
K
P
L
S
-------------
T
C
G
S
H
L
I
A
I
F
L
F
Y
I
T
V
-------
I
I
M
Y
I-------RPSSS--H------------S------M
D
T
D
K
-----------
I
A
S
V
F
Y
T
M
I
I
P
M
L
S
P
I
V
Y
T
L
RNK
D
V
K
N
A
F
M
K
V
V
E
K
A
K
YSLDSVF------------------------------
5
PsiBlast_PDB
88.33
23%
-159
- C2 -
3REY
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----------
L
-
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
--------
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
A
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
8
PsiBlast_PDB
87.79
23%
-158
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----------
L
-
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
--------
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
A
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
7
PsiBlast_PDB
87.70
23%
-158
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----------
L
-
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
--------
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
A
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
6
PsiBlast_PDB
86.78
23%
-158
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----------
L
-
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
--------
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
A
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
4
PsiBlast_PDB
86.62
23%
-162
- C2 -
3PWH
1
?
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----------
L
-
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
--------
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
A
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
17
PsiBlast_PDB
85.95
22%
-153
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
----------
S
A
A
-
A
A
D
I
L
-
V
G
V
L
A
I
P
-
F
A
I
A
I
S
TGFCA
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
KEG
K
A
---
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------
10
PsiBlast_PDB
85.49
23%
-157
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-
T
---------
I
S
T
G
-----
F
C
A
A
C
H
G
----
C
L
---
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
-------
S
Q
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
GERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
------------------------------------
9
PsiBlast_PDB
85.49
23%
-157
- C2 -
3VG9
8
?
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-
T
---------
I
S
T
G
-----
F
C
A
A
C
H
G
----
C
L
---
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
-------
S
Q
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
NYMVY
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
P
L
P
GERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------
30
HHSearch
83.94
18%
-139
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-------------------------------------------------------------------------------------
L
----------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
---------
A
H
K
R
M
R
T
V
----
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
-
T
Y
A
V
H
N
E
-
W
Y
Y
G
L
F
-----
Y
C
K
F
--
H
----
N
F
---
F
P
I
A
A
V
F
A
S
I
----
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
-
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
------
M
P
S
R
V
V
C
M
-
I
E
---
W
P
E
H
----------
P
-------
N
K
-
I
Y
E
K
V
Y
-----
H
I
C
V
T
V
-----
L
---
I
Y
F
L
P
L
L
V
I
G
Y
-----------
A
Y
T
V
V
G
I
T
------
L
W
---
A
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
V
K
-------------
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-------
H
I
F
F
L
-------
L
P
Y
I
N
--
P
------------
D
LYLKKF
I
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
------------------------------
15
PsiBlast_PDB
82.55
22%
-156
- C2 -
2YDV
6
?
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
----------
S
A
A
-
A
A
D
I
L
-
V
G
V
L
A
I
P
-
F
A
I
A
I
S
T
GFCA
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
Q
---S
T
L
Q
K
E
V
H
-----
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------
14
PsiBlast_PDB
81.90
22%
-153
- C2 -
2YDO
3
?
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
----------
S
A
A
-
A
A
D
I
L
-
V
G
V
L
A
I
P
-
F
A
I
A
I
S
T
GFCA
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
K
Q
-----------
M
--------------------
E
S
----T
L
Q
K
E
V
H
------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------
16
PsiBlast_PDB
80.72
22%
-161
- C2 -
4UG2
3
?
A:
[16-304]
-------------------------------------------------------------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
---------
L
N
S
N
L
Q
N
V
----
T
N
Y
F
V
V
----------
S
A
A
-
A
A
D
I
L
-
V
G
V
L
A
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
--
C
----
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
----
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
-----
A
I
G
L
T
P
M
L
G
W
--
N
-
N
------
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
-
Q
V
A
C
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
R
R
Q
L
----------------------------------------A
R
S
T
L
Q
K
E
V
H
---
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------
39
Fugue
80.29
16%
-125
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
---------
Q
H
K
K
L
R
T
P
----
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-
Y
T
S
L
H
G
Y
-
F
V
F
G
P
T
-----
G
C
N
L
--
E
----
G
F
---
F
A
T
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
---
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
-
T
N
N
E
S
F
-----
V
I
Y
M
F
V
-----
V
---
H
F
I
I
P
L
I
V
I
F
F
-----------
C
Y
G
Q
L
V
F
T
------
V
K
---
E
A
A
A
S
A
-----------
T
--------------------
T
Q
K
A
E
K
-------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-------
W
L
P
Y
A
-------
G
V
A
F
Y
--
I
------------
F
------
T
H
Q
G
S
DFGPIFM----
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A--------------------
33
HHSearch
79.34
14%
-144
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
----------------------------------------------------------------------------------
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
---------
K
T
K
S
L
Q
T
P
----
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
-
I
S
C
F
L
K
K
-
W
I
F
G
F
A
-----
A
C
K
V
--
Y
----
G
F
---
I
G
G
I
F
G
F
M
S
I
----
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
-----
E
G
V
L
C
N
C
S
-
F
D
---
Y
I
------------
S
-------
R
D
-
S
T
T
R
S
N
-----
I
L
C
M
F
I
-----
L
---
G
F
F
G
P
I
L
I
I
F
F
-----------
C
Y
F
N
I
V
M
S
------
V
S
---
N
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
-------------
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-------
A
V
V
A
L
-------
L
A
Q
F
G
--
P
LEW---------
V
------
T
P
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
------------------------------
42
Fugue
74.74
25%
-160
- C2 -
5AHR
2
A:
[1-343]
S
M
T
C
P
FYKKIPGTGFTVDAFQYGVVEGCT
A
Y
F
L
THFHSDHYAGLSKH
F
T
F
P
V
Y
C
S
E
I
T
G
N
L
L
K
N
---------------
K
L
H
V
Q
E
Q
----------------
Y
I
H
P
L
P
L
D
T
E
C
I
V
N
G
----
V
K
V
V
L
---------
L
D
A
N
-
H
C
P
G
A
V
M
I
L
F
Y
L
P
N
G
T
-------------
V
I
L
H
T
G
D
F
R
A
D
-
P
S
M
E
R
S
-----
L
L
A
D
--
Q
K
V
H
M
L
Y
---
L
D
T
T
Y
C
S
P
E
Y
----
T
F
P
S
Q
Q
E
V
I
R
F
A
I
--
N
T
A
F
E
A
V
T
L
N
-
P
H
--
A
L
V
V
C
G
T
Y
S
I
G
K
E
K
V
F
L
A
I
A
D
V
L
G
S
K
V
G
M
S
-----------
Q
E
---
K
Y
K
T
L
Q
C
L------
N
-------
I
P
-
E
I
N
S
L
I
-----
T
--------------
T
D
M
C
S
S
L
V
H
L
L
-----------
P
M
M
Q
I
N
F
K
------
G
L
---
Q
S
H
L
K
K
----------------------------------------------------
C
G
G
K
Y
N
Q
I
L
A
F
R
P
T
V
I
P
Q
T
K
GN
I
S
I
Y
G
-------
I
P
Y
S
E
--
H
------------
S
--------
S
Y
L
-----------
E
M
K
R
F
V
Q
W
L
K
P
--
Q
K
I
I
P
T
V
N
V
G
T
W
K
S
R
S
T
M
E
K
Y
F
R
E
W
K
L
E
A
G
Y
------------------------------
31
HHSearch
73.67
15%
-125
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
------------------------------------------------------------------------------------
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
---------
Q
H
K
K
L
R
T
P
----
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-
Y
T
S
L
H
G
Y
-
F
V
F
G
P
T
-----
G
C
N
L
--
E
----
G
F
---
F
A
T
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-----
E
G
M
Q
C
S
C
G
-
I
D
---
Y
Y
T
---
P
-------
H
-------
E
E
-
T
N
N
E
S
F
-----
V
I
Y
M
F
V
-----
V
---
H
F
I
I
P
L
I
V
I
F
F
-----------
C
Y
G
Q
L
V
F
T
------
V
K
---
E
A
A
A
Q
Q
-----------
Q
ESA
T
T
Q
K
A
------------
E
K
E
V
T
R
-------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-------
A
G
V
A
F
-------
Y
I
F
T
H
QG
S
D-----------
F
------
G
P
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
------------------------------
29
HHSearch
70.79
17%
-122
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
---------------------------------------------------------------------------------
L
N
K
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
---------
Y
S
R
V
G
R
S
V
----
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
-
A
S
K
-
V
N
G
-
W
I
F
G
T
F
-----
L
C
K
V
--
V
----
S
L
---
L
K
E
V
N
F
Y
S
G
I
----
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
-
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
-----
N
N
S
S
P
V
C
Y
-
E
V
---
L
G
------------
N
-------
D
T
A
K
W
R
M
V
L
-----
R
I
L
P
H
T
-----
F
---
G
F
I
V
P
L
F
V
M
L
F
-----------
C
Y
G
F
T
L
R
T
------
L
F
---
K
A
H
M
G
------------
Q
--------------------
K
H
R
A
M
R
-------------
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
-------
N
L
V
L
L
-------
A
D
T
L
M
--
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
-----------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-------------------------------------
40
Fugue
70.59
14%
-107
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
---------
Q
H
K
K
L
R
T
P
----
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-
Y
T
S
L
H
G
Y
-
F
V
F
G
P
T
-----
G
C
N
L
--
E
----
G
F
---
F
A
T
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
-
T
N
N
E
S
F
-----
V
I
Y
M
F
V
-----
V
---
H
F
I
I
P
L
I
V
I
F
F
-----------
C
Y
G
Q
L
V
F
T
------
V
K
---
E
A
A
A
Q
Q
-----------
Q
--------------------
E
S
A
T
T
Q
-------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
-------
L
P
Y
A
G
--
V
------------
A
------
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------
2
PsiBlast_PDB
70.30
23%
-146
- C2 -
4IB4
9
5HT2B_HUMAN (first)
A:
[38-224]
------------------------------------------------------------------------------------------------------------
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
---------
L
E
K
K
L
Q
Y
A
----
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
-
L
T
I
M
F
E
A
M
W
P
L
P
L
V
-----
L
C
P
A
--
W
----
L
F
---
L
D
V
L
F
S
T
A
S
I
----
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
-
A
N
Q
Y
N
-
S
R
A
T
A
F
I
K
I
T
--
V
V
W
L
I
--
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
-----------
N
P
---
N
N
I
T
C
V
L
-------
T
-------
K
E
-
R
F
G
D
F
M
-------
L
F
G
S
-----
L
---
A
A
F
F
T
P
L
A
I
M
I
-----------
V
T
Y
F
L
T
I
H
------
A
L
---
Q
K
K
A
A
D
-----------
L
--------------------
E
D
N
W
E
T
-------------
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
-------
V
K
D
A
L
-------
T
K
M
R
A
--
A
------------
A
------
L
D
A
Q
K
-----------
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
------------------------------
45
Fugue
68.14
15%
-138
- C1 -
4PG7
9
?
A:
[20-446]
--------------H
M
K
K
L
N
I
A
L
LGLG
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
K
D
I
V
I
K
H
I
L
V
R
D
K
S
K
---------------
K
R
P
L
N
I
S
----------------
Q
Y
H
L
T
E
D
V
N
E
I
L
N
D
D
S
L
D
I
I
V
E
V
M
GGI
E
P
T
V
D
W
L
R
T
A
L
K
N
K
----
K
H
V
I
T
A
N
K
D
L
L
A
V
H
L
K
L
L
E
-
D
L
A
E
E
-
N
G
V
A
L
K
F
-
E
A
S
V
A
G
-----
G
P
N
N
--
I
----
S
K
---
F
M
G
I
L
N
G
T
S
N
----
F
I
L
S
K
M
T
K
E
Q
-----
T
T
F
E
E
A
L
D
E
A
-
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
--
N
-
Q
V
I
K
L
N
D
V
K
-
R
R
---
G
I
S
G
V
T
L
-------
T
-------
D
I
-
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
-----
Y
E
NG
K
V
N
A
S
V
E
P
T
L
I
DKKHQLAAVED
E
Y
N
A
I
Y
V
I
GDAV
G
D
T
M
---
F
Y
G
K
G
A
-----------
G
--------------------
S
L
A
T
G
S
-------------
A
V
V
S
D
L
L
N
V
A
L
F
F
E
S
T
-------
L
P
P
H
F
-------
E
L
K
T
D
--
K
------------
T
------
R
E
M
E
K
-------------
S
N
F
F
V
V
V
N
H
V
K
G
S
I
E
N
F
E
N
E
L
K
A
I
L
P
F
H
R
S
L
R
V
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
GLESSP
E
E
L
I
T
K
H
GYEVD
K
V
Y
P
V
E
GV