@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PE2R2_HUMAN: (2016-01-14 )
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
Atome Classification :
(20 SA)
.........10-....-.....20....--.--...30........40........50........60...-.....70........80....-....90........100.......110.......120.......130.......140.....---..150.......160.......170..-.-.----...180..-----..-----------...-------..-------190---..-------.-------.-----.--.-..200.......210.......220.......230......---------------------------.-----------------------------------------------240------.---------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------.-------------------------------------------------------------.-----------------------------------------------------------------------------.------------------.-------------------.-------------..-------------250.......260.......270.......280---......-.290-----------.----.------.--.....300...-.-..-.310.......320....-...330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGNASNDSQS--EDCE-TRQWLPPGES
P
--
A
--
I
S
S
V
M
F
S
A
G
V
L
G
N
L
I
A
L
A
L
L
A
R
R
WRGDVGCSAGRRS
S
L
-
S
L
F
H
V
L
V
T
E
L
V
F
T
D
L
L
G
T
C
L
I
-
S
P
V
V
L
A
S
YARN
Q
T
L
V
A
LAPESRA
C
T
Y
F
A
F
A
M
T
F
F
S
L
A
T
M
L
M
L
F
A
M
A
L
E
R
Y
L
SIGH
P
Y
F
Y
Q
R
R
---VSRSG
G
L
A
V
L
P
V
I
Y
A
V
S
L
L
F
CS
L
P
L
LD-Y-G----
Q
Y
V
Q--YC-----PG-----------
T
W
C
-------
F
I
-------RH----G
R
-------
T
-------
A
-----
Y
--
L
-
Q
L
Y
A
T
L
L
L
L
L
I
V
S
V
L
AC
N
F
S
V
I
L
N
L
I
R
M
H
R
R
S
R
R
SRCGPSL---------------------------G-----------------------------------------------S--------G---------------------------------------------------------------------------------------------------------------------------R------------------------------------------------------------G-------------------------------------------------------------G-----------------------------------------------------------------------------P------------------G-------------------A-------------RR-------------RGERVSMAEETDH
L
I
L
L
A
I
M
T
I
T
F
A
V
C
SL
P
F
T
I
---
F
A
Y
MNE-TSS------------
R
----
K
------
E
--
K
W
D
L
Q
A
L
R
F
L
S
-
I
-
N
S-II
D
P
W
V
F
A
ILR
P
P
V
L
R
L
M
-
R
S
V
L
C
C
R
I
S
LRTQDATQTSCSTQSDASKQADL
24
HHSearch
94.55
18%
-144
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------
V
V
G
M
G
--
I
--
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-----------
E
R
L
Q
-
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
---
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
----
R
A
T
H
--
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
-------
C
D
-------
F
F
----
T
N
-------
Q
-------
A
-----
Y
--
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GR------------------------------------
N
--------
T
---------------------------------------------------------------------------------------------------------------------------
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
--------------------------------------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
-----------------------------------------------------------------------------
K
S
R
W
Y
N
-------------
Q
-------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
-------------
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
---
V
N
I
V
H
V
-
I
Q
D
NL----------
I
----
R
------
K
--
E
V
Y
I
L
L
N
W
I
G
Y
-
V
-
N
S
-
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
--------------------------
30
HHSearch
88.59
16%
-141
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------
Y
A
--
L
--
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
-----------
R
A
L
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
---
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
-
N
----
T
T
G
----------
D
P
-----------
T
V
C
-------
S
I
-------
S
N
----
P
D
---------------
F
-----
V
--
I
-
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
---------------------------
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
--------
D
E
--------------------------------------------------------------------------------------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
-------------------------------------------------------------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
---------------------------------------------------------------
N
------------------
Q
-------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
-------------
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
---
T
H
V
L
N
T
-
H
C
Q
TCH---------
V
----
S
------
P
--
E
L
Y
S
A
T
T
W
L
G
Y
-
V
-
N
S
-
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
-
L
K
I
L
S
C
--------------------------
29
HHSearch
87.85
17%
-149
- C3 -
3EML
13
ENLYS_BPT4
A:
[20-472]
----------------------
G
S
S
V
Y
I
--
T
--
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
-----------
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
----
N
C
G
Q
----------
S
QGCGEGQ----
V
A
C
-------
L
F
-------
E
D
----
V
V
-------
P
M
------
N
-----
Y
M
V
Y
-
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
D
TEGYYTIGIGHLL-------
T
-----------------------------------------------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
---------------------------------------------
Q
------------------------------------------------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
--------------------------------------------
T
-----------------------------------------------------------------------------
P
------------------
N
R
A
K
R
V
I
T
T
F
R
T--------
G
-------------
T
W
-------------
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
---
I
N
C
F
T
F
-
F
C
P
DCSH--------
A
----
P
------
L
--
W
L
M
Y
L
A
I
V
L
S
H
-
T
-
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
-
R
K
I
I
R
S
H
V
L
R
Q
---------------------
43
Fugue
87.08
20%
-132
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------
S
--
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
--
A
--
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
-----------
P
W
-
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
-
Y
V
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
---
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
--
P
I
L
F
-
Y
S
G
----
T
G
V
R
--
K
N
-----
K
T
-----------
I
T
C
YDTTSDE
Y
L
-------
R
S
----
Y
F
-------
I
-------
Y
-----
S
--
M
-
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
---------------------------
N
-----------------------------------------------
P
--------
E
---------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------
G
-------------------------------------------------------------
D
-----------------------------------------------------------------------------
P
------------------
D
NGVNPGTDFKDIVCPLCGV
G
-------------
K
D
-------------
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
---
M
K
T
M
N
L
-
R
A
R
------------
L
----
D
------
F
--
Q
--------
T
P
-
A
-
M
C
-
A
F
N
D
R
V
Y
A
T
Y
Q
--
V
T
R
G
L
-
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------
26
HHSearch
85.27
15%
-142
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------
P
L
V
--
V
--
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
-----------
R
K
L
H
-
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
---
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
-
W
-
N
----
H
------
R
-----
R
E
-----------
D
K
C
-------
E
T
-------
D
F
----
Y
D
-------
V
-------
T
W
----
F
K
-
V
-
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
-
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVI-----------------------------
T
--------
K
---------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------
E
-------------------------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
-------------------
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-------------------
T
-------------
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
---
F
F
M
V
I
A
-
F
C
K
------------
N
CC--
N
------
E
--
H
L
H
M
F
T
I
W
L
G
Y
-
I
-
N
S
-
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
-
K
R
I
L
H
I
--------------------------
32
HHSearch
81.62
16%
-147
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-328]
------------------------
V
L
W
A
--
A
--
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
-----------
K
R
M
R
-
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
---
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
------
T
T
E
T
--
M
P
-----
S
R
-----------
V
V
C
-------
M
I
-------
E
W
----
P
E
-------
H
PNKIY
E
K
V
-----
Y
--
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
---
F
F
L
L
P
Y
-
I
N
P
------------
D
----
L
YLKKFI
Q
--
Q
V
Y
L
A
I
M
W
L
A
M
-
S
-
S
T
-
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
-
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
28
HHSearch
81.19
14%
-140
* C3 *
2Z73
5
OPSD_TODPA
A:
[31-334]
--------------------
D
A
V
Y
Y
S
L
G
--
I
--
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-----------
K
S
L
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
---
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
-
G
----
A
Y
T
L
--
E
G
-----
V
L
-----------
C
N
C
-------
S
F
-------
D
Y
----
I
S
-------
R
D
S
T
T
R
S
-
N
-----
I
--
L
-
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------
K
-------------
E
L
-------------
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
---
V
A
L
L
A
Q
-
F
G
P
------------
L
EWV-
T
------
P
--
Y
A
A
Q
L
P
V
M
F
A
K
-
A
-
S
A
-
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
-
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
41
Fugue
79.38
15%
-104
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
VP
F
S
N
K
-
T
G
V
V
R
S
P
F
E
A
P
--
Q
YY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
----
R
Y
I
P
--
E
G
-----
M
Q
-----------
C
S
C
-------
G
I
----------------------
D
-------
Y
-----
Y
--
T
-
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-------
G
Q
L
V
---------------------------
F
-----------------------------------------------
T
--------
V
---------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------
E
-------------------------------------------------------------
A
-----------------------------------------------------------------------------
A
------------------
A
-------------------
Q
-------------
Q
Q
-------------
E
S
A
-
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
---
V
A
F
Y
I
F
-
T
H
Q
------------
G
----
S
------
D
FG
P
I
F
M
T
I
P
A
F
F
A
-
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
-
V
T
T
L
C
C
G
K
N
-
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
42
Fugue
78.69
13%
-129
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VP
F
S
N
K
-
T
G
V
V
R
S
P
F
E
A
P
QY
Y
--
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
----
R
Y
I
P
--
E
G
-----
M
Q
-----------
C
S
C
-------
G
I
DYYTPHE
E
T
----
N
N
-------
E
-------
S
-----
F
--
V
-
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
---
V
A
F
Y
I
F
-
T
H
-------------
Q
----
G
------
S
--
D
F
G
P
I
F
M
T
I
P
A
-
F
-
F
A
-
K
T
S
A
----
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
25
HHSearch
75.54
14%
-133
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
--------------------
E
N
S
I
K
L
T
S
--
V
--
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
-----------
K
K
F
H
-
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
---
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
-
N
----
C
I
S
----------
A
L
-----------
S
S
C
-------
S
T
-------
V
L
----
P
L
YH-----
K
-------
H
-----
Y
--
I
-
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
E
G
L
R
---------------------------
L
-----------------------------------------------
K
--------
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
--------------------------------------------------
T
-------------------------------------------------------------
F
-----------------------------------------------------------------------------
R
------------------
T
-------------------
G
-------------
T
W
-------------
D
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
---
L
L
L
L
D
V
-
G
C
K
------------
V
KTC
D
I
------
L
--
F
R
A
E
Y
F
L
V
L
A
V
-
L
-
N
S
-
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
-
I
R
I
M
G
R
P
L
------------------------
22
HHSearch
74.18
16%
-123
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-498]
-------------------
A
N
F
N
K
I
F
L
P
--
T
--
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
-----------
K
K
L
R
-
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
---
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
-
N
----
V
S
E
---
A
D
-----
D
R
-----------
Y
I
C
-------
D
R
-------
F
Y
----
P
N
-------
D
-------
L
W
V
V
V
F
Q
--
F
-
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
---------------------------
L
-----------------------------------------------
R
--------
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
-----------------
Q
------------------------------------------------------------
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------------------------
F
-----------------------------------------------------------------------------
R
------------------
T
-------------------
G
-------------
T
W
-------------
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
---
G
I
S
I
D
S
-
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
----
V
------
H
--
K
W
I
S
I
T
E
A
L
A
F
-
F
-
H
C
-
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
-
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------
31
HHSearch
73.50
15%
-128
- C3 -
1U19
14
OPSD_BOVIN
A:
[37-329]
--------------------
P
W
Q
F
S
M
L
A
--
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-----------
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
---
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
----
R
Y
I
P
--
E
G
-----
M
Q
-----------
C
S
C
-------
G
I
-------
D
Y
----
Y
T
PHEETN
N
E
-------
S
-----
F
V
-
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
---
V
A
F
Y
I
F
-
T
H
Q
GSD---------
F
----
G
------
P
--
I
F
M
T
I
P
A
F
F
A
K
-
T
-
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
-
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
16
PsiBlast_PDB
73.44
21%
-146
- C3 -
3VG9
7
?
A:
[75-289]
-------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
NCGQ--
S
Q
--
G
C
GE---
G
Q
-----------
V
A
C
-------
L
F
-------
E
D
VVPM
N
Y
-------
M
-------
V
-----
Y
--
F
-
N
F
F
A
C
V
L
V
P
L
L
L
M
L
-----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------
G
-------------------
E
-------------
R
A
-------------
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
S
------------
H
----
A
------
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
-
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
-
R
K
I
I
R
S
H
V
L
R
----------------------
17
PsiBlast_PDB
72.85
21%
-144
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[75-289]
-------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
NCGQ--
S
Q
--
G
C
GE---
G
Q
-----------
V
A
C
-------
L
F
-------
E
D
VVP
M
N
Y
-------
M
-------
V
-----
Y
--
F
-
N
F
F
A
C
V
L
V
P
L
L
L
M
L
-----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------
G
-------------------
E
-------------
R
A
-------------
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
S
------------
H
----
A
------
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
-
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
-
R
K
I
I
R
S
H
V
L
-----------------------
21
HHSearch
72.06
12%
-142
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
----------------------
E
V
V
F
I
V
--
L
--
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
-----------
R
H
L
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
---
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
-
Q
----
F
I
V
G
VR
T
V
-----
E
D
-----------
G
E
C
-------
Y
I
-------
Q
F
----
F
S
-------
N
A
------
A
-----
V
T
-
F
-
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
L
---------------------------
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT--
K
--------
D
---------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------
A
-------------------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
------------------
P
-------------------
N
R
A
K
R
V
I
T
T
F
R
T--
G
T
-------------
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
---
M
V
L
I
N
T
-
F
C
A
PC----------
I
----
P
------
N
--
T
V
W
T
I
G
Y
W
L
C
Y
-
I
-
N
S
-
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
-
K
H
L
L
M
---------------------------
8
PsiBlast_PDB
71.78
22%
-129
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[97-292]
----------------------------------------------------------------------------------------------------------------------------------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
----
W
R
D
E
--
D
P
-----
Q
A
-----------
L
K
C
-------
Y
Q
-------
D
P
----
G
C
-------
C
-------
D
-----
F
--
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
D
------------
L
----
V
------
P
--
D
W
L
F
V
A
F
N
W
L
G
-
Y
A
N
S
-
A
M
N
P
I
I
Y
C
--
R
S
P
D
F
R
K
A
-
F
K
R
L
L
A
--------------------------
18
PsiBlast_PDB
71.60
21%
-160
- C3 -
2YDO
3
?
A:
[75-289]
-------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
----
N
C
G
Q
--
P
K
-----
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
-------
L
F
-------
E
D
VVP
M
N
Y
-------
M
-------
V
-----
Y
--
F
-
N
F
F
A
C
V
L
V
P
L
L
L
M
L
-----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
S
------------
H
----
A
------
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
-
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
-
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
-------
3
PsiBlast_PDB
71.36
22%
-128
- C3 -
2Y01
12
ADRB1_MELGA
A:
[97-292]
----------------------------------------------------------------------------------------------------------------------------------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
----
W
R
D
E
--
D
P
-----
Q
A
-----------
L
K
C
-------
Y
Q
-------
D
P
----
G
C
-------
C
-------
D
-----
F
--
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
D
------------
L
----
V
------
P
--
D
W
L
F
V
A
F
N
W
L
G
-
Y
A
N
S
-
A
M
N
P
I
I
Y
C
--
R
S
P
D
F
R
K
A
-
F
K
R
L
L
A
--------------------------
20
PsiBlast_PDB
70.99
21%
-159
- C3 -
4UG2
3
?
A:
[75-289]
-------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
----
N
C
G
Q
--
P
K
-----
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
-------
L
F
-------
E
D
VVP
M
N
Y
-------
M
-------
V
-----
Y
--
F
-
N
F
F
A
C
V
L
V
P
L
L
L
M
L
-----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
S
------------
H
----
A
------
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
-
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
-
R
K
I
I
R
S
H
V
L
R
----------------------
6
PsiBlast_PDB
70.86
22%
-130
- C3 -
2Y04
13
ADRB1_MELGA
A:
[97-292]
----------------------------------------------------------------------------------------------------------------------------------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
----
W
R
D
E
--
D
P
-----
Q
A
-----------
L
K
C
-------
Y
Q
-------
D
P
----
G
C
-------
C
-------
D
-----
F
--
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
D
------------
L
----
V
------
P
--
D
W
L
F
V
A
F
N
W
L
G
-
Y
A
N
S
-
A
M
N
P
I
I
Y
C
--
R
S
P
D
F
R
K
A
-
F
K
R
L
L
A
--------------------------