@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PRLHR_HUMAN: (2016-01-14 )
MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......-120..---..-...130.......140.......150.......160.......170.-----........---180-.---........190.....-...-200-..-..----.--..210....----...--220-........230.......240......--.250..-.....260----.---------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------.....270.......--------280.......290.......---300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASSTTRGP
R
V
S
D
L
FSGLPPAVTTPANQSAEASAGNGSVAGADAPAVT
P
F
Q
S
L
Q
L
V
H
Q
L
K
G
L
I
V
L
L
Y
S
V
V
V
V
V
G
L
V
G
N
C
L
L
V
L
V
I
A
R
V
R
R
L
H
N
V
T
N
F
L
I
G
N
L
A
L
S
D
V
L
M
C
T
ACV
P
L
T
L
A
-
Y
AFEP---R
G
-
W
V
FG
G
G
L
C
H
L
V
F
F
LQP
V
T
V
Y
V
S
V
F
T
L
T
T
I
AV
D
R
Y
V
V
L
V
H
P
L
R
R
R
--
I
-----
S
L
R
L
S
A
Y
A
---
V
---
L
---
A
I
W
A
L
S
A
V
L
A-LP
A
A
V
-
H
T
Y
-
H
V
E
-LK-P
H
----
D
--
V
R
L
C
E
E
F
WG----
S
Q
E
--
R
Q
--
R
Q
L
Y
A
W
G
L
L
L
V
T
Y
L
L
P
L
L
V
I
L
L
S
Y
V
R
V
--
S
V
K
LRN-RVVPGCV-----T---------------------------------------------------------------------------------------------------------------------------------------Q-----------------------------------------------------------------------------------------------------------------------------------------------------S------------------------------------------------------------------------------------------------QA
D
W
D
R
A
R
R
R
R
T
F
C
L
--------
L
V
V
I
V
V
V
F
A
V
C
W
L
P
L
H
V
F
N
L
---
L
R
DLDPHAI
D
P
Y
A
F
G
L
V
Q
L
L
C
H
W
L
A
M
S
S
ACYN
P
F
I
Y
A
W
L
H
D
S
F
R
E
E
L
R
K
L
L
V
A
W
P
R
KIAPHGQ
N
M
T
V
S
V
VI
32
HHSearch
90.30
23%
-161
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
-------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
-
Y
T
V
-
I
---
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
VK
R
-----
T
T
K
M
A
G
M
M
---
I
---
A
---
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
-
F
W
Q
-
F
I
V
-
G
V
R
T
V
----
E
--
D
G
E
C
Y
I
Q
F
F
----
S
--------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
--
S
R
A
S
K
S
-
R
I
N
I
F
E
M
L
R
I
D
E
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
---------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
--------
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
---
I
N
T
F
C
A
P
C
I
-
P
---
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------
1
PsiBlast_PDB
89.61
33%
-162
- C5 -
4EA3
3
C562_ECOLX (first)
A:
[124-405]
----------------------------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
-----
V
L
L
T
L
P
-
F
Q
G
T
D
I
L
L
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
---------------
T
S
S
K
A
---
Q
A
V
N
V
---
A
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
-
M
G
--
S
A
Q
-
V
E
-
D
E
----
E
--
I
E
C
L
V
E
I
P
T
----
P
Q
D
--
Y
W
--
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
--
I
R
R
L
R
G
V
R
L
L
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
D
R
N
L
R
R
I
T
R
L
V
--------
L
V
V
V
A
V
F
V
G
-
C
W
T
P
V
Q
V
F
V
L
---
A
Q
G
L
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
-
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------
33
HHSearch
88.92
26%
-164
* C5 *
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
-
H
I
L
-
M
---
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
SL
L
-----
T
K
N
K
A
R
V
I
---
I
---
L
---
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
-
R
A
T
-
H
Q
-
E
A
I
N
C
Y
A
--
E
E
T
C
C
D
F
F
-----------
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
--
F
Q
E
A
K
R
-
Q
L
N
I
F
E
M
-----
L
---------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
------------------------------------------------------------------------------------------------
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
--------
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------
21
PsiBlast_CBE
88.60
33%
-164
- C5 -
4EA3
3
C562_ECOLX (first)
B:
[124-407]
----------------------------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
-----
V
L
L
T
L
P
-
F
Q
G
T
D
I
L
L
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
-
R
A
--
L
-----
D
V
R
T
S
S
K
A
---
Q
A
V
N
V
---
A
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
-
M
G
--
S
A
-----------
E
--
I
E
C
L
V
E
I
P
T
----
P
Q
D
--
Y
W
--
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
--
I
R
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
N
L
R
R
I
T
R
L
V
--------
L
V
V
V
A
V
F
V
G
-
C
W
T
P
V
Q
V
F
V
L
---
A
Q
G
L
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
-
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
---------------------
40
HHSearch
88.27
23%
-160
- C5 -
3EML
13
ENLYS_BPT4
A:
[23-472]
-------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
-
I
S
T
------
G
-
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
-----
T
G
T
R
A
K
G
I
---
I
---
A
---
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
-
G
W
N
-
N
C
G
-
Q
-----------
S
Q
G
C
G
E
G
Q
V
ACLF
E
D
V
--
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
R
R
-
Q
L
N
I
F
E
M
-----
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--------------------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
--------
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------
26
PsiBlast_CBE
87.39
31%
-167
- C5 -
4RWA
2
C562_ECOLX (first)
A:
[125-405]
--------------------------------------------------------------
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
------
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
--
L
-----
D
F
R
T
P
A
K
A
---
K
---
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
-
M
A
V
-
T
----
R
-
P
R
----
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
--
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
--
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
S
K
E
K
D
R
S
L
R
R
I
T
R
-
M
--------
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
--
D
P
L
V
V
A
A
L
H
-
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------
41
HHSearch
87.25
24%
-164
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
-
L
E
V
T
G
---
G
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
--
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
---
I
---
T
---
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
-
G
F
N
-
T
T
G
----------
D
--
P
T
V
C
S
I
S
N
---------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
--
Y
V
V
L
K
Q
-
R
R
R
K
N
I
F
-----
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW--------------------------------------------------------------------------------
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
--------
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
---
L
N
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------
34
HHSearch
87.05
30%
-158
- C5 -
2KS9
1
NK1R_HUMAN
A:
[34-327]
-------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
-
Y
A
V
-
H
---
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--
L
-----
S
A
T
A
T
K
V
V
---
I
---
C
---
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
-
Y
S
T
-
T
E
T
-
M
---
P
----
S
--
R
V
V
C
M
I
E
W
P
----
E
H
P
NK
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
--
G
I
T
L
W
A
-
S
E
I
P
G
D
S
-----
S
---------------------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
--------
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
25
PsiBlast_CBE
86.85
31%
-164
- C5 -
4RWA
1
C562_ECOLX (first)
B:
[125-403]
--------------------------------------------------------------
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
------
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
--
L
-----
D
F
R
T
P
A
K
A
---
K
---
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
-
M
A
V
-
T
----
R
-
P
R
----
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
--
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
--
L
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
S
K
E
K
D
R
S
L
R
R
I
T
R
-
M
--------
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
--
D
P
L
V
V
A
A
L
H
-
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-----------------------
22
PsiBlast_CBE
86.27
31%
-164
- C5 -
4N6H
22
OPRD_HUMAN
A:
[128-408]
--------------------------------------------------------------
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
------
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
--
L
-----
D
F
R
T
P
A
K
A
---
K
---
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
-
M
A
V
-
T
----
R
-
P
R
----
D
GA
V
V
C
M
L
Q
F
P
S
----
P
S
W
--
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
--
L
L
R
L
R
S
-
V
R
----
L
-----
L
---------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
S
K
E
K
D
R
S
L
R
R
I
T
R
-
M
--------
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
--
D
P
L
V
V
A
A
L
H
-
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
---------------
24
PsiBlast_CBE
85.77
31%
-161
- C5 -
4RWD
6
C562_ECOLX (first)
A:
[125-405]
--------------------------------------------------------------
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
------
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
--
L
-----
D
F
R
T
P
A
K
A
---
K
---
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
-
M
A
V
-
T
----
R
-
P
R
----
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
--
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
--
L
L
R
L
R
S
-
V
R
----
L
-----
L
---------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
S
K
E
K
D
R
S
L
R
R
I
T
R
-
M
--------
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
--
D
P
L
V
V
A
A
L
H
-
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------
36
HHSearch
85.60
21%
-166
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
--------------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
-
Y
L
L
-
M
---
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
KY
R
-----
T
K
T
R
A
S
A
T
---
I
---
L
---
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
--
G
W
N
-
H
-------
R
----
R
--
E
D
K
C
E
T
D
F
Y
----
D
V
--------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
--
Y
K
A
V
R
Q
-
H
C
N
I
F
E
M
-----
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLT------------------------------------------------------------------------------------------------------------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--------------------------------------------------------------------------------
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
--------
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
---
V
I
A
F
C
K
N
C
C
N
----
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------
23
PsiBlast_CBE
85.34
31%
-161
- C5 -
4RWD
5
C562_ECOLX (first)
B:
[125-405]
--------------------------------------------------------------
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
------
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
--
L
-----
D
F
R
T
P
A
K
A
---
K
---
L
INI
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
-
M
A
V
-
T
----
R
-
P
R
----
D
GA
V
V
C
M
L
Q
F
P
S
----
P
S
W
--
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
--
L
L
R
L
R
S
-
V
R
----
L
-----
L
---------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
S
K
E
K
D
R
S
L
R
R
I
T
R
-
M
--------
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
VWT
L
V
D
I
D
R
R
--
D
P
L
V
V
A
A
L
H
-
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---------------------
4
PsiBlast_PDB
82.98
32%
-153
- C5 -
2KSB
1
NK1R_HUMAN
A:
[39-313]
------------------------------------------------------------------
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
-
Y
A
V
H
----
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--
L
-----
S
A
T
A
T
K
V
V
---
I
---
C
---
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
-
Y
S
--
T
T
E
-
T
M
-
P
S
----
R
--
V
-
V
C
M
I
E
W
P
----
E
H
P
--
N
K
IY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
--
G
I
T
L
W
A
-
S
E
I
P
G
D
S
-----
S
---------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
-
M
--------
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
3
PsiBlast_PDB
82.98
32%
-153
- C5 -
2KSA
1
NK1R_HUMAN
A:
[39-313]
------------------------------------------------------------------
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
-
Y
A
V
H
----
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--
L
-----
S
A
T
A
T
K
V
V
---
I
---
C
---
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
-
Y
S
--
T
T
E
-
T
M
-
P
S
----
R
--
V
-
V
C
M
I
E
W
P
----
E
H
P
--
N
K
IY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
--
G
I
T
L
W
A
-
S
E
I
P
G
D
S
-----
S
---------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
-
M
--------
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
2
PsiBlast_PDB
82.98
32%
-153
- C5 -
2KS9
1
NK1R_HUMAN
A:
[39-313]
------------------------------------------------------------------
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
-
Y
A
V
H
----
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--
L
-----
S
A
T
A
T
K
V
V
---
I
---
C
---
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
-
Y
S
--
T
T
E
-
T
M
-
P
S
----
R
--
V
-
V
C
M
I
E
W
P
----
E
H
P
--
N
K
IY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
--
G
I
T
L
W
A
-
S
E
I
P
G
D
S
-----
S
---------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
-
M
--------
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
7
PsiBlast_PDB
82.95
25%
-173
- C5 -
3SN6
1
R:
[187-490]
----------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
-
H
I
L
-
T
---
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
SL
L
-----
T
K
N
K
A
R
V
I
---
I
---
L
---
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
Y
R-
Q
E
A
I
N
-
C
Y
----
A
--
E
E
T
C
C
D
F
F
T
----
N
Q
A
---------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
--
F
Q
E
A
K
R
-
Q
L
Q
K
I
D
K
-----
S
---------------------------------------------------------------------------------------------------------------------------------------
E
GR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
KEHKALKT
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---
V
H
V
I
Q
D
N
L
I
R
K
E
V
Y
----
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
-
F
R
I
A
F
Q
E
L
L
C
-------------------
10
PsiBlast_PDB
82.69
28%
-161
- C5 -
2Y02
13
ADRB1_MELGA
A:
[6-300]
------------------------------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
--
F
G
-
A
T
L
V
V
---
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
--------
S
L
M
T
R
A
R
A
K
V
I
I
---
C
---
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
-
P
Q
----
A
--
L
K
C
Y
Q
D
P
G
C
----
C
D
F
--
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
--------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
---
V
N
V
F
N
R
D
L
V
P
D
W
L
F
----
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-
F
R
K
A
F
K
R
L
L
-
A
------------------
8
PsiBlast_PDB
82.63
28%
-162
- C5 -
2Y00
13
ADRB1_MELGA
A:
[6-300]
------------------------------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
--
F
G
-
A
T
L
V
V
---
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
--------
S
L
M
T
R
A
R
A
K
V
I
I
---
C
---
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
-
P
Q
----
A
--
L
K
C
Y
Q
D
P
G
C
----
C
D
F
--
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
--------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
---
V
N
V
F
N
R
D
L
V
P
D
W
L
F
----
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-
F
R
K
A
F
K
R
L
L
-
A
------------------
13
PsiBlast_PDB
82.57
28%
-158
- C5 -
4AMJ
12
ADRB1_MELGA
A:
[6-300]
------------------------------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
--
F
G
-
A
T
L
V
V
---
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
--------
S
L
M
T
R
A
R
A
K
V
I
I
---
C
---
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
-
P
Q
----
A
--
L
K
C
Y
Q
D
P
G
C
----
C
D
F
--
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
--------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
---
V
N
V
F
N
R
D
L
V
P
D
W
L
F
----
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-
F
R
K
A
F
K
R
L
L
-
A
------------------