@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0128: (2015-11-28 )
MYKISKLILSALKANKYTKVIVLFSSIFVILFSVIYCNYSLRDNFLSSYRDSSVSLKSVLENSIIKKYHYLLIEKHHIKYKSFDYINQLVKLRAELLQSVGEVKDLGLILYDQNSRIIFSHFNTQDHDYEQLLTNDEIDKLLNNQEIFYTIGHTLISIFPIFHENDTKPSFFLKIIQNHDNFYVMVYSLFLTFLGLLLIILILVMLYLHFSNTQMLVKQHKTNIELQQMKEALEQENTNKLKFFASVTHELRTPLNAIIGFAELIKNETLGSMDNYQYKEYVDDIYNAGTHLLALINDVLDFSKAESSSLTVEKVKFNLNKIIDSCLNMLSPKLKETGISLEKEIPNRQLLVIADPKRMKQVIINLLSNSIKFTPKDGLIRMVIKENIEKNLLTIEFHDNGIGIMQQDIYKVMSVFGQADSGYRNEGTGIGLPLSKKLVELMGGTFNIKSEAKLGTTITLNFFYEEQTCEDLIDF
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190---.......200.......210.......220....-...230.......240.......250.......260.......270---.....-...280.......--.290........300.......---310....-------..--.320.......330.....-----.--------.---340-..-----....-..350.......360.......370....------.-------.-------.380.......390.......400.......410.......420-.--------....--...430.......440........450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MY
K
I
S
K
L
I
L
S
A
L
KANK
Y
T
K
V
I
V
L
F
S
S
I
F
V
I
L
F
S
V
I
YCNY
S
L
R
D
N
F
L
S
S
YRDSS
V
S
L
K
S
V
L
E
N
S
I
I
K
K
Y
H
Y
L
L
I
E
K
HHIKYK
S
F
D
Y
I
N
Q
L
V
K
L
R
A
E
L
L
Q
S
V
GEVK
D
L
G
L
I
L
Y
DQN
S
R
I
I
F
S
HFNTQD
H
D
Y
E
Q
LL
T
N
D
E
I
D
K
L
LNNQ
E
I
F
Y
T
I
G
H
T
L
I
S
I
F
P
I
FHENDT
K
P
S
F
F
L
K
I
I
QNHD
N
F
Y
V
M
V
Y
S
L
F
L
T
---
F
L
G
L
L
L
I
I
L
I
L
V
M
L
Y
L
HFS
N
T
Q
M
L
V
K
Q
HKTNI
E
L
-
Q
Q
M
K
E
A
L
E
QENTN
K
L
K
F
F
A
S
V
T
H
E
L
R
T
P
L
N
A
I
I
G
F
A
E
L
I
K
NETLG----SMD
N
Y
-
Q
Y
K
E
-
Y
V
D
D
I
Y
N
A
--
G
T
-
H
L
L
A
L
I
N
D
V
L
D
FSKAESSS---
L
T
V
E
K
V
K
-------
F
N
--
L
N
K
I
I
D
S
C
L
N
MLS
P
K
L
K
ET-----G--------I---S
L
--
E
K-----EIPN-
R
Q
L
L
V
IA
D
P
K
R
M
K
Q
V
I
I
N
L
L
SNS
I
K
FTPK------D-------
G
-------
L
I
R
M
V
I
K
ENIEKN
L
L
T
I
E
FHDNGI
G
I
M
Q
Q
D
I
Y
K
V
M
S
V
FGQADS--G--------YRNE--GTGIGL
P
L
S
K
K
L
V
E
-LMGG
T
F
N
IKSEAKL
G
T
T
I
T
L
N
F
F
YE
E
Q
T
C
E
D
L
IDF
7
PsiBlast_PDB
91.12
26%
-90
- C3 -
4U7O
1
?
A:
[25-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
-
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
----
A
W
K
D
P
-
E
V
A
P
-
G
F
L
K
V
T
Q
E
--
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
---
T
R
V
D
M
E
L
-------
V
N
--
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
-----
D
NPA
K
Y
---
Y
---
T
I
--
K
R
-----
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
------
G
-------
G
-------
V
V
T
C
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
---------------QG
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
----------
4
PsiBlast_PDB
86.84
34%
-60
- C3 -
4JAV
6
?
A:
[11-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT------
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
----------
21
PsiBlast_CBE
86.28
34%
-60
- C3 -
4JAV
6
?
B:
[11-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT------
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
----------
1
PsiBlast_PDB
86.23
34%
-62
- C3 -
4JAS
2
?
A:
[13-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
T
I
I
E
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
------
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
---------
2
PsiBlast_PDB
85.99
34%
-72
- C3 -
4JAU
1
?
A:
[11-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
T
I
I
E
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
-------------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
-----------
5
PsiBlast_PDB
84.78
34%
-71
- C3 -
2C2A
2
?
A:
[11-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-------------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
--------
6
PsiBlast_PDB
84.31
26%
-91
- C3 -
4U7N
-
?
A:
[39-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
----
A
W
K
D
P
-
E
V
A
P
-
G
F
L
K
V
T
Q
E
--
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
---
T
R
V
D
M
E
L
-------
V
N
--
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
-----
D
NY------
Y
---
T
I
--
K
R
-----
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
------
G
-------
G
-------
V
V
T
C
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
---------------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
----------
3
PsiBlast_PDB
84.11
34%
-64
- C3 -
3DGE
3
?
A:
[14-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
L
F
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
PD
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT------
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
--------
8
PsiBlast_PDB
83.01
27%
-65
- C3 -
4Q20
-
DIVL_CAUCR
A:
[25-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
-
A
D
R
S
A
A
L
A
E
A
E
R
L
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
-------
D
--
S
E
-
R
G
R
N
-
H
V
A
A
V
R
A
A
--
A
T
-
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
---
M
A
L
E
I
E
D
-------
I
-----
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
G
--
G
--------
V
---
T
L
--
A
V
-----
E
C
E
E
-
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
------
G
-------
G
-------
R
V
T
L
S
A
R
R
A
L
G
E
--
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
--
G
--------------
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
Q
---------
22
PsiBlast_CBE
82.35
34%
-64
- C3 -
3DGE
2
?
B:
[14-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
LF
E
S
-----
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
PDK----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT------
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
--------
55
HHSearch
81.35
31%
-39
- C- -
2C2A
2
?
A:
[13-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
----
L
-
D
L
S
-
T
L
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
-
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
---
L
Q
I
N
R
E
K
-------
V
D
--
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
--------
V
---
N
V
--
L
F
-----
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
------
D
-------
A
P
D
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-------------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
--------
44
Fugue
79.10
19%
-64
- C3 -
4I5S
-
?
A:
[37-432]
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
----------------------------------------
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
--------------
N
D
M
A
Q
K
Q
L
N
-------
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
---
F
----------
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
-
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
---
G
----
A
L
T
E
S
-
V
A
P
S
-
F
I
K
V
S
L
D
E
--
T
N
-
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
--------
L
D
V
E
L
-------
T
N
--
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
-----
S
--------
T
---
E
I
--
I
R
-----
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
------
G
-------
G
-------
K
V
T
I
T
M
Q
T
T
--
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
---------------
R
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
------------
56
HHSearch
75.66
27%
-83
- C3 -
3A0R
1
?
A:
[130-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
D
D
-------
P
E
-
T
L
K
K
-
Y
I
N
I
I
T
N
E
--
L
S
-
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
-------
V
L
E
F
T
E
-------
F
N
--
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
M
-----
N
--------
I
---
D
F
--
C
F
-----
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
------
N
-------
G
-------
K
I
K
I
T
S
E
D
--
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
----------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
P
E
K
R
------
49
Fugue
73.80
16%
-63
- C3 -
1GKZ
8
BCKD_RAT
A:
[38-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
T
P
T
M
M
L
Y
S
G
R
S
Q
D
G
S
H
L
L
K
S
G
R
Y
L
Q
Q
E
L
P
V
R
I
A
H
R
I
K
G
F
R
S
L
P
F
I
I
G
C
N
P
T
I
L
H
V
H
E
L
Y
I
R
A
F
Q
K
L
T
D
F
P
P
I
K
D
Q
A
D
E
A
Q
Y
C
Q
L
V
R
Q
L
L
D
D
H
K
D
V
V
T
L
L
A
E
G
L
R
E
S
R
K
----
H
I
E
D
E
K
L
V
R
Y
-
F
L
D
K
T
L
T
S
--
R
L
-
G
I
R
M
L
A
T
H
H
L
A
L
H
E
D
K
P
D
F
---
V
G
I
I
C
T
R
-------
L
S
--
P
K
K
I
I
E
K
W
V
D
F
A
R
R
L
C
E
H
K
YG
N
A
P
R
--------
V
---
R
I
--
N
G
-----
H
V
A
A
-
R
---
F
P
F
I
P
M
P
L
D
Y
I
L
P
E
L
L
K
N
A
M
R
A
T
M
E
S
H
LDTP
Y
-------
N
-------
V
P
D
V
V
I
T
I
A
N
N
D
V
D
L
I
I
R
I
S
D
R
G
G
G
I
A
H
K
D
L
D
R
V
M
D
Y
H
---
F
T
--
T
--------
A
P
M
H
--
G
F
G
F
G
L
P
T
S
R
A
Y
A
E
-
Y
L
G
G
S
L
Q
L
Q
S
L
Q
G
I
G
T
D
V
Y
L
R
L
R
H
I
D
G
R
E
E
-----
10
PsiBlast_PDB
73.74
25%
-67
- C3 -
3D36
4
?
A:
[19-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
S
H
E
I
R
N
P
L
T
A
A
R
G
F
I
Q
L
I
E
E
Q
P
L
A
----
A
D
K
R
R
-
Q
Y
A
R
I
A
I
E
E
L
D
R
A
--
E
-----
A
I
I
T
D
Y
L
T
F
A
K
P
A
P
E
T
---
P
E
K
L
N
V
K
-------
L
E
--
I
E
R
V
I
D
----
I
L
R
P
L
A
N
M
S
-----
C
--------
V
---
D
I
--
Q
A
-----
T
L
A
---
P
F
S
V
I
G
E
R
E
K
F
R
Q
C
L
L
N
V
M
K
N
A
I
E
A
M
P
N
------
G
-------
G
-------
T
L
Q
V
Y
V
--
S
I
D
N
G
R
V
L
I
R
I
A
D
T
G
V
G
M
T
K
E
Q
L
E
R
L
G
E
P
Y
F
T
T
K
G
-------------
V
K
--
G
T
G
L
G
M
M
V
V
Y
R
I
I
E
-
S
M
N
G
T
I
R
I
E
S
E
I
H
K
G
T
T
V
S
I
Y
L
P
L
A
S
---------
12
PsiBlast_PDB
70.85
23%
-49
- C3 -
4KP4
4
ENVZ_ECOLI
A:
[9-218]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
R
T
L
L
M
A
G
V
S
H
D
L
R
T
P
L
T
R
I
R
A
Y
A
E
T
I
Y
N
-
S
L
G
----
E
L
D
L
S
-
T
L
K
E
-
L
A
E
S
I
N
K
D
--
I
E
-
E
C
N
A
I
I
E
Q
F
I
D
Y
L
R
T
-
G
Q
E
---
M
P
M
E
M
A
---------
D
--
L
N
A
V
L
G
E
V
I
A
A
E
S
G
Y
E
R
E
--------------------
I
--
E
T
-----
A
L
Y
P
-
G
S
I
E
V
K
M
H
P
L
S
I
K
R
A
V
A
N
M
V
V
N
A
A
R
Y
--
G
------
N
-------
G
-------
W
I
K
--
V
S
S
G
T
E
P
N
R
A
W
F
Q
V
E
D
D
G
P
G
I
A
P
E
Q
R
K
H
L
F
Q
P
F
V
R
G
D
S
--
A
--------
R
T
I
S
--
G
T
G
L
G
L
A
I
V
Q
R
I
V
D
-
N
H
N
G
M
L
E
L
G
T
S
E
R
G
G
L
S
I
R
A
W
L
P
V
P
V
T
--------
9
PsiBlast_PDB
70.54
26%
-48
- C3 -
4I5S
-
?
A:
[211-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
---
G
----
A
L
T
E
S
-
V
A
P
S
-
F
I
K
V
S
L
D
E
--
T
N
-
R
M
M
R
M
I
T
D
L
L
S
L
S
R
---
S
H
---
L
D
V
E
L
T
N
-------
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
S
T
--------------------
E
I
--
I
R
-----
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
------
G
-------
G
-------
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
--
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
--------
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
------------
54
HHSearch
69.49
16%
-51
- C3 -
2E0A
2
PDK4_HUMAN
A:
[82-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
E
F
H
E
K
S
P
D
D
Q
K
A
L
S
D
F
V
D
T
L
I
K
V
R
N
R
H
H
N
V
V
P
T
M
A
Q
G
I
I
E
Y
K
D
A
C
T
V
D
P
V
T
N
Q
-
N
L
Q
Y
-
F
L
D
R
F
Y
M
N
R
I
S
T
-
R
M
L
-
M
N
Q
H
I
L
I
F
S
D
S
Q
T
G
N
PSH
I
G
S
I
D
P
N
-------
C
D
--
V
V
A
V
V
Q
D
A
F
E
C
S
R
M
L
C
D
Q
Y
-----
Y
L
S
S
P
E
L
K
L
T
---
Q
V
--
N
G
-----
K
F
P
D
-
Q
P
I
H
I
V
Y
V
P
S
H
L
H
H
M
L
F
E
L
F
K
N
A
M
R
A
T
V
E
------
H
-------
Q
E
NQP
S
L
T
P
I
E
V
I
V
V
L
--
G
K
E
D
L
T
I
K
I
S
D
R
G
G
G
V
P
L
R
I
I
D
R
L
F
S
Y
T
Y
S
T
A
P
TP
N
--------
A
P
L
A
--
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
-
Y
F
Q
G
D
L
N
L
Y
S
L
S
G
Y
G
T
D
A
I
I
Y
L
K
A
L
S
S
E
S
I
E
K
L
P
V
62
HHSearch
68.41
31%
-84
- C3 -
3SL2
2
A:
[3-153]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
--
I
V
R
F
M
S
L
I
I
D
R
F
E
M
T
K
-
E
Q
------------------
E
F
--
I
R
-----
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
------
G
-------
G
-------
H
V
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
--------------
L
G
--
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
---------
57
HHSearch
68.35
16%
-65
- C3 -
2Q8G
1
PDK1_HUMAN
A:
[102-367]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
K
A
I
Y
D
F
T
D
T
V
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
I
E
Y
K
E
S
FD--
P
V
T
S
Q
-
N
V
Q
Y
-
F
L
D
R
F
Y
M
S
--
R
I
-
S
I
R
M
L
L
N
Q
H
S
L
L
F
G
-------------
K
H
IGSINPN
C
N
--
V
L
E
V
I
K
D
G
Y
E
N
A
R
R
L
C
D
L
Y
-----
Y
--------
I
N
S
P
E
L
--
E
L
E
E
L
NA
K
S
P
G
-
Q
P
I
Q
V
V
Y
V
P
S
H
L
Y
H
M
V
F
E
L
F
K
N
A
M
R
A
T
M
E
------
H
H
ANRG
V
Y
P
-------
P
I
Q
V
H
V
T
L
--
G
N
E
D
L
T
V
K
M
S
D
R
G
G
G
V
P
L
R
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
--
R
PRVETSRA
V
P
L
A
--
G
F
G
Y
G
L
P
I
S
R
L
Y
A
Q
-
Y
F
Q
G
D
L
K
L
Y
S
L
E
G
Y
G
T
D
A
V
I
Y
I
K
A
L
S
T
D
S
I
E
R
L
P
V