@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0358: (2015-11-30 )
MDIENNLQDLKRKFNYIERKLENPTNLSQKEFINLSKEYSELRPIIKIINEYDTLKKEILDLEEIIKDENSEYDIKELAKEEFFEKQKVLLPQVKAKLKLALLPKDEDDSRNAILEIRAGTGGEEAALFAAMLFRMYQKYAERRNWKFEPISISSTGIGGYKEASALINGTEVFARLKFESGVHRVQRVPETESSGRLHTSAATVAILPEVEEVDFKIEEKDLRIDVYRSSGPGGQSVNTTDSAVRVTHLPTEMVVIQQDEKSQHKNKAKALKVLRARLYEIERQKKEIERSTMRKSQIGSGDRSERIRTYNFPQSRITDHRINLTSHQLEQIIKEGELDEFIEVLISRNEAERLAGES
Atome Classification :
(20 SA)
--------------------------.....---....10........20......-.-.30...-.....40.----.......50-...--------------.....60.---------......-.70.---.......80........-90........-----100.-......110..------.....120------------------..--------------......130---.....-...-----140.---------------------------------.------------.....150.....-----..160.......170.------....---..180-----.......------.190.---....--------------------..200.......210-----------..-.-.-...-..220......-.230.......---240---.....--------------------.---------------------.------250---.-----------------.---.-------------------------.-----.....260....-...270....-....280.-......290----------.-..--.....300.......310--------...-----....320.......330.......340.-----------......350.---.--.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------MDI
E
N
---
N
L
Q
D
L
K
R
K
F
N
Y
I
E
R
K
LENPTNL-
S
-
Q
K
E
F
I
N
-
L
S
K
E
Y
S
E
L
----
R
P
I
I
K
I
I
N
E
-
Y
D
T
--------------
L
K
K
E
I
L
D
L
---------
E
E
I
IKD-ENSE---Y
D
I
K
E
L
A
K
E
E
F
F
E
K
Q
K
V
-
L
L
P
Q
V
K
A
K
L
K
-----
L
A
L
L-PKDEDDSR
N
A
I
------
L
E
I
RAGT-------------------GG--------------
E
E
A
A
L
F
A
A
----
M
L
F
R
M
-
Y
Q
K
-----
Y
A
E
R---------------------------------R------------NWKF
E
P
I
S
I
SSTG-----IGG
Y
K
E
A
S
A
L
I
N
G
T
E
V
------
F
A
R
L
---
K
F
E
S------
G
V
H
R
V
Q
R------VPETE---SSG
R
--------------------
L
HTS
A
A
T
V
A
ILPE-------------VE-E-V-
D
F
K
-
I
EEK
D
L
R
I
D
V
Y
-RSSGPGGQSVN---TTD---
S
A
V
R
V
--------------------T---------------------H------L-----P-----------------
T
---
E
-------------------------
M
-----
V
V
I
QQD
E
K
S
Q
H
K
-
N
K
A
K
A
-
L
K
V
L
-
R
A
R
L
Y
E
I
E
-
R
Q
K
K
E
I
E
R
-----------
S
-
T
M
--
R
K
SQIGSGDRS
E
R
I
R
TYN--------F
P
Q
-----
S
RITD
H
R
INL
T
S
H
Q
L
E
Q
I
I
KEG
E
L
D
E
F
I
-----------
E
V
L
I
SRN
E
A
E
---
R
--LAGES-
26
HHSearch
90.01
49%
-63
- C11 -
2B3T
-
RF1_ECOLI
B:
[7-354]
------------------------------
A
---
K
L
E
A
L
H
E
R
H
E
E
V
Q
A
L
L
G
D
A
Q
T
I
-
A
D
Q
E
R
F
R
A
-
L
S
R
E
Y
A
Q
L
----
S
D
V
S
R
C
F
T
D
-
W
Q
Q
--------------
V
------------------------------------------------------
Q
Q
L
Q
-----
V
L
L
L
-
P
K
D
P
D
D
E
R
N
A
F
------
L
E
V
R
A
G
T
-------------------
G
G
--------------
D
E
A
A
L
F
A
G
----
D
L
F
R
M
-
Y
S
R
-----
Y
A
E
A
---------------------------------
R
------------
R
W
R
V
E
I
M
S
A
S
E
G
E
-----
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
------
Y
G
R
L
---
K
F
E
S
------
G
G
H
R
V
Q
R
------
V
P
A
T
E
---
S
Q
G
R
--------------------
I
H
T
S
A
C
T
V
A
V
M
P
E
-------------
L
P
-
D
-
A
E
L
P
D
-
V
N
P
A
D
L
R
I
D
T
F
-
R
S
S
G
A
G
G
Q
H
V
N
---
T
T
D
---
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
V
E
C
Q
D
E
R
S
Q
H
K
-
N
K
A
K
A
-
L
S
V
L
-
G
A
R
I
H
A
A
E
-
M
A
K
R
Q
--------------------
R
R
N
-------
S
D
R
N
R
T
Y
N
--------
F
P
Q
-----
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
E
V
M
-
E
G
K
L
D
M
L
I
-----------
E
P
I
I
Q
E
H
Q
A
D
---
Q
--
L
A
----
1
PsiBlast_PDB
88.10
51%
-63
- C11 -
2B3T
-
RF1_ECOLI
B:
[28-354]
-----------------------------------------------------
T
I
A
-
D
-
Q
E
R
F
R
A
-
L
S
R
E
Y
A
Q
L
----
S
D
V
S
R
C
F
T
D
-
W
Q
Q
--------------
V
------------------------------------------------------
Q
Q
L
Q
-----
V
L
L
L
-
P
K
D
P
D
D
E
R
N
A
F
------
L
E
V
R
A
G
T
-------------------
G
G
--------------
D
E
A
A
L
F
A
G
----
D
L
F
R
M
-
Y
S
R
-----
Y
A
E
A
---------------------------------
R
------------
R
W
R
V
E
I
M
S
A
S
E
G
E
-----
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
------
Y
G
R
L
---
K
F
E
S
------
G
G
H
R
V
Q
R
------
V
P
A
T
E
---
S
Q
G
R
--------------------
I
H
T
S
A
C
T
V
A
V
M
P
E
-------------
L
P
-
D
-
A
-
E
L
P
D
V
N
P
A
D
L
R
I
D
T
F
-
R
S
S
G
A
G
G
Q
H
V
N
---
T
T
D
---
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
V
E
C
Q
D
E
R
S
Q
H
K
-
N
K
A
K
A
-
L
S
V
L
-
G
A
R
I
H
A
A
E
-
M
A
K
R
Q
--------------------
R
R
N
-------
S
D
R
N
R
T
Y
N
--------
F
P
Q
-----
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
E
V
M
-
E
G
K
L
D
M
L
I
-----------
E
P
I
I
Q
E
H
Q
A
D
---
Q
--
L
A
----
30
HHSearch
85.31
50%
-50
* C11 *
1RQ0
-
RF1_THEMA
A:
[1-333]
--------------------------------------
M
K
E
K
K
K
E
I
E
K
L
L
A
R
P
D
L
T
-
P
--
E
Q
M
K
N
-
Y
G
M
E
Y
A
K
I
----
E
E
I
E
N
I
T
N
R
-
I
K
E
--------------
T
Q
E
F
I
-------------
E
L
L
R
---
E
E
------
G
--
E
N
E
L
E
I
-
E
K
Y
E
K
-
E
L
D
Q
L
Y
Q
E
L
L
-----
F
L
L
S
----
P
E
A
S
D
K
A
I
------
V
E
I
R
P
G
T
-------------------
G
G
--------------
E
E
A
A
L
F
A
R
----
D
L
F
R
M
-
Y
T
R
-----
Y
A
E
R
---------------------------------
K
------------
G
W
N
L
E
V
A
E
I
H
E
T
D
-----
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
------
Y
G
I
L
---
K
Y
E
S
------
G
V
H
R
V
Q
R
------
V
P
V
T
E
---
S
G
G
R
--------------------
I
H
T
S
T
A
T
V
A
V
L
P
E
-------------
I
E
-
E
-
K
-
D
I
E
-
I
R
P
E
D
L
K
I
E
T
F
-
R
A
S
G
----
Y
V
N
---
K
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
V
S
C
Q
N
E
R
S
Q
Y
Q
-
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
L
Y
Q
L
Q
-
K
E
Q
K
E
R
E
I
-----------
S
-
Q
------------
R
S
E
K
I
R
T
Y
N
--------
F
P
Q
-----
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
E
I
L
-
D
G
D
L
D
E
I
I
-----------
S
K
L
I
E
H
D
I
E
N
---
N
--
L
E
E
V
L
-
3
PsiBlast_PDB
80.19
56%
-58
- C11 -
1RQ0
-
RF1_THEMA
A:
[69-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
L
Y
Q
E
L
L
-----
F
L
L
S
-
P
E
A
S
D
---
K
A
I
------
V
E
I
R
P
G
T
-------------------
G
G
--------------
E
E
A
A
L
F
A
R
----
D
L
F
R
M
-
Y
T
R
-----
Y
A
E
R
---------------------------------
K
------------
G
W
N
L
E
V
A
E
I
H
E
T
D
-----
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
------
Y
G
I
L
---
K
Y
E
S
------
G
V
H
R
V
Q
R
------
V
P
V
T
E
---
S
G
G
R
--------------------
I
H
T
S
T
A
T
V
A
V
L
P
E
-------------
I
E
-
E
-
K
-
D
I
E
-
I
R
P
E
D
L
K
I
E
T
F
-
R
A
S
G
----
Y
V
N
---
K
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
V
S
C
Q
N
E
R
S
Q
Y
Q
-
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
L
Y
Q
L
Q
-
K
E
Q
K
E
R
E
I
-----------
S
-
Q
------------
R
S
E
K
I
R
T
Y
N
--------
F
P
Q
-----
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
E
I
L
-
D
G
D
L
D
E
I
I
-----------
S
K
L
I
E
H
D
I
E
N
---
N
--
L
E
E
V
L
-
27
HHSearch
68.45
48%
25
- C11 -
1ZBT
-
RF1_STRMU
A:
[2-358]
---------------------------
N
I
Y
D
---
Q
L
Q
A
V
E
D
R
Y
E
E
L
----------------------
R
E
E
A
N
S
----
R
E
T
V
A
V
Y
R
E
-
Y
K
Q
--------------
V
V
Q
N
I
A
D
A
---------
Q
E
M
------
P
E
---
L
E
E
--
M
A
K
E
E
L
-
K
N
S
K
V
-
A
K
E
E
Y
E
E
K
L
R
-----
F
L
L
L
-
P
K
D
P
N
D
D
K
N
I
I
------
L
E
I
R
G
A
A
-------------------
G
G
--------------
D
E
A
A
L
F
A
G
----
D
L
L
N
M
-
Y
Q
K
-----
Y
A
E
N
---------------------------------
Q
------------
G
W
K
F
E
V
M
E
A
S
A
N
G
-----
V
G
G
L
K
E
V
V
A
M
V
S
G
Q
S
V
------
Y
S
K
L
---
K
Y
E
S
------
G
A
H
R
V
Q
R
------
V
P
V
T
E
---
S
Q
G
R
--------------------
V
H
T
S
T
A
T
V
L
V
M
P
E
-------------
V
E
-
E
-
V
-
E
Y
E
-
I
D
P
K
D
L
R
V
D
I
Y
-
H
A
------------
K
V
A
---
T
A
V
R
I
--------------------
I
---------------------
H
------
L
-----
P
-----------------
T
---
N
-------------------------
I
-----
K
V
E
M
Q
E
E
R
T
Q
Q
K
-
N
R
D
K
A
-
M
K
I
I
-
R
A
R
V
A
D
H
F
-
A
Q
I
A
Q
D
E
Q
-----------
D
-
A
------
T
V
G
T
G
D
R
S
E
R
I
R
T
Y
N
--------
F
P
Q
-----
N
R
V
T
D
H
R
I
G
L
T
L
Q
K
L
D
S
I
L
-
S
G
K
L
D
E
V
I
-----------
D
A
L
I
L
Y
D
Q
T
Q
---
K
--
L
E
E
L
N
-
6
PsiBlast_PDB
62.53
36%
30
- C11 -
1GQE
-
RF2_ECOLI
A:
[31-359]
---------------------------------------
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
-
N
-
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
----
E
A
V
V
D
T
L
D
Q
-
M
K
Q
--------------
G
L
E
D
V
S
G
L
---------
L
E
L
A
V
E
-
A
D
D
E
---
E
T
F
N
E
A
V
A
E
L
D
A
L
E
E
K
L
-------
A
Q
L
E
-----
F
R
R
M
-
F
S
G
E
Y
D
S
A
D
C
Y
------
L
D
I
Q
A
G
S
-------------------
G
G
--------------
T
E
A
Q
D
W
A
S
----
M
L
E
R
M
-
Y
L
R
-----
W
A
E
S
---------------------------------
R
------------
G
F
K
T
E
I
I
E
E
S
E
G
E
-----
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
------
Y
G
W
L
---
R
T
E
T
------
G
V
H
R
L
V
R
------
K
S
P
F
D
---
S
G
G
R
--------------------
R
H
T
S
F
S
S
A
F
V
Y
P
E
-------------
V
D
-
D
D
I
-
D
I
E
-
I
N
P
A
D
L
R
I
D
V
Y
-
R
A
S
G
A
G
G
Q
H
V
N
---
R
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
T
Q
C
Q
N
D
R
S
Q
H
K
-
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
L
Y
E
V
E
-
M
Q
K
K
N
A
E
K
-----------
Q
-
A
M
ED
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
--------
L
D
D
-----
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
A
V
L
-
D
G
S
L
D
Q
F
I
-----------
E
A
S
L
K
A
G
L
--------------
28
HHSearch
61.95
36%
27
- C11 -
1GQE
-
RF2_ECOLI
A:
[25-363]
------------------------------
L
---
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
-
N
E
P
E
R
A
Q
A
-
L
G
K
E
R
S
S
L
----
E
A
V
V
D
T
L
D
Q
-
M
K
Q
--------------
G
L
E
D
V
S
G
L
---------
L
E
L
A
V
E
A
D
D
E
E
---
T
F
N
--
E
A
V
A
E
L
-
D
A
L
E
E
-
K
L
A
Q
L
E
F
R
---------
R
M
-
F
S
G
E
Y
D
S
A
D
C
Y
------
L
D
I
Q
A
G
S
-------------------
G
G
--------------
T
E
A
Q
D
W
A
S
----
M
L
E
R
M
-
Y
L
R
-----
W
A
E
S
---------------------------------
R
------------
G
F
K
T
E
I
I
E
E
S
E
G
E
-----
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
------
Y
G
W
L
---
R
T
E
T
------
G
V
H
R
L
V
R
------
K
S
P
F
D
---
S
G
G
R
--------------------
R
H
T
S
F
S
S
A
F
V
Y
P
E
-------------
V
D
D
D
-
I
-
D
I
E
-
I
N
P
A
D
L
R
I
D
V
Y
-
R
A
S
G
A
G
G
Q
H
V
N
---
R
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
T
Q
C
Q
N
D
R
S
Q
H
K
-
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
L
Y
E
V
E
-
M
Q
K
K
N
A
E
K
-----------
Q
-
A
M
--
E
-
D
N
K
S
D
I
G
W
G
S
Q
I
R
S
Y
V
--------
L
D
D
-----
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
A
V
L
-
D
G
S
L
D
Q
F
I
-----------
E
A
S
L
K
A
G
L
--------------
38
Fugue
59.22
34%
29
- C11 -
1GQE
-
RF2_ECOLI
A:
[4-365]
---------IN
P
V
N
N
R
I
Q
D
L
T
E
R
S
D
V
L
R
G
Y
L
---
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
N
E
-
P
E
R
A
Q
A
-
L
G
K
E
R
S
S
L
----
E
A
V
V
D
T
L
D
Q
M
K
Q
G
--------------
L
E
D
V
S
G
L
L
---------
E
L
A
V
E
A
-
D
D
-----
E
E
T
F
N
E
A
V
A
E
L
D
A
L
E
E
K
-
L
A
Q
L
E
F
R
-----------
R
M
F
S
G
E
Y
D
S
A
D
C
Y
------
L
D
I
Q
A
G
S
-------------------
G
G
--------------
T
E
A
Q
D
W
A
S
M
---
L
--
E
R
M
Y
L
R
-----
W
A
E
S
---------------------------------
R
------------
G
F
K
T
E
I
I
E
E
S
E
G
E
-----
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
------
Y
G
W
L
---
R
T
E
T
------
G
V
H
R
L
V
R
------
K
S
P
F
D
---
S
G
G
R
--------------------
R
H
T
S
F
S
S
A
F
V
Y
P
E
-------------
V
D
-
D
D
I
-
D
I
E
-
I
N
P
A
D
L
R
I
D
V
Y
-
R
A
S
G
A
G
G
Q
H
V
N
---
R
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
T
Q
C
Q
N
D
R
S
Q
H
K
-
N
K
D
Q
A
M
K
Q
--
M
K
A
K
L
Y
E
V
E
M
Q
K
K
N
A
E
K
Q
-----------
A
M
E
D
--
N
K
S
D
I
G
W
G
S
---
Q
I
R
S
Y
V
--------
L
D
D
-----
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
A
V
L
-
D
G
S
L
D
Q
F
I
-----------
E
A
S
L
K
A
G
L
--------------
2
PsiBlast_PDB
52.22
56%
154
- C- -
2FVO
-
RF1_THEMA
A:
[69-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
L
Y
Q
E
L
L
-----
F
L
L
S
-
P
E
A
S
D
---
K
A
I
------
V
E
I
R
P
G
T
-------------------
G
G
--------------
E
E
A
A
L
F
A
R
----
D
L
F
R
M
-
Y
T
R
-----
Y
A
E
R
---------------------------------
K
------------
G
W
N
L
E
V
A
E
I
H
E
T
D
-----
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
------
Y
G
I
L
---
K
Y
E
S
------
G
V
H
R
V
Q
R
------
V
P
V
T
E
---
S
G
G
R
--------------------
I
H
T
S
T
A
T
V
A
V
L
P
E
-------------
I
E
-
E
-
K
-
D
I
E
-
I
R
P
E
D
L
K
I
E
T
F
-
R
A
S
G
------------
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
V
S
C
Q
N
E
R
S
Q
Y
Q
-
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
L
Y
Q
L
Q
-
K
E
Q
K
E
R
E
I
-----------
S
-
Q
------------
R
S
E
K
I
R
T
Y
N
--------
F
P
Q
-----
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
E
I
L
-
D
G
D
L
D
E
I
I
-----------
S
K
L
I
E
H
D
I
E
N
---
N
--
L
E
E
V
L
-
35
HHSearch
48.68
32%
-36
- C11 -
2JY9
-
?
A:
[7-102]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
-
I
A
D
N
E
L
E
I
T
A
I
-
R
A
Q
G
A
G
G
Q
H
V
N
---
K
T
S
---
S
A
I
H
L
--------------------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
-----
I
-----------------
S
DDG
V
-------------------------
I
-----
I
I
K
A
Q
E
F
R
S
Q
E
L
-
N
R
E
A
A
-
I
A
R
L
-
V
A
V
I
K
E
L
T
-
A
E
Q
K
S
R
R
A
-----------
T
-
R
P
--
T
R
A
S
K
E
R
R
L
S
S
K
A
Q
K
S
S
V
--------
K
A
L
-----
R
G
K
V
R
R
P
L
D
L
E
H
H
H
H
H
H
--------------------------------------------
4
PsiBlast_PDB
48.09
37%
199
- C- -
1MI6
-
RF2_ECOLI
A:
[31-359]
---------------------------------------
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
-
N
-
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
----
E
A
V
V
D
T
L
D
Q
-
M
K
Q
--------------
G
L
E
D
V
S
G
L
---------
L
E
L
A
V
E
-
A
D
D
E
---
E
T
F
N
E
A
V
A
E
L
D
A
L
E
E
K
L
-------
A
Q
L
E
-----
F
R
R
M
-
F
S
G
E
Y
D
S
A
D
C
Y
------
L
D
I
Q
A
G
S
-------------------
G
G
--------------
T
E
A
Q
D
W
A
S
----
M
L
E
R
M
-
Y
L
R
-----
W
A
E
S
---------------------------------
R
------------
G
F
K
T
E
I
I
E
E
S
E
G
E
-----
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
------
Y
G
W
L
---
R
T
E
T
------
G
V
H
R
L
V
R
------
K
S
P
F
D
---
S
G
G
R
--------------------
R
H
T
S
F
S
S
A
F
V
Y
P
E
-------------
V
D
-
D
D
I
-
D
I
E
-
I
N
P
A
D
L
R
I
D
V
Y
-
R
A
S
G
A
G
G
Q
H
V
N
---
R
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
T
Q
C
Q
N
D
R
S
Q
H
K
-
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
L
Y
E
V
E
-
M
Q
K
K
N
A
E
K
-----------
Q
-
A
M
ED
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
--------
L
D
D
-----
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
A
V
L
-
D
G
S
L
D
Q
F
I
-----------
E
A
S
L
K
A
G
L
--------------
5
PsiBlast_PDB
47.71
37%
199
- C- -
1ML5
1
RF2_ECOLI
Z:
[31-359]
---------------------------------------
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
-
N
-
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
----
E
A
V
V
D
T
L
D
Q
-
M
K
Q
--------------
G
L
E
D
V
S
G
L
---------
L
E
L
A
V
E
-
A
D
D
E
---
E
T
F
N
E
A
V
A
E
L
D
A
L
E
E
K
L
-------
A
Q
L
E
-----
F
R
R
M
-
F
S
G
E
Y
D
S
A
D
C
Y
------
L
D
I
Q
A
G
S
-------------------
G
G
--------------
T
E
A
Q
D
W
A
S
----
M
L
E
R
M
-
Y
L
R
-----
W
A
E
S
---------------------------------
R
------------
G
F
K
T
E
I
I
E
E
S
E
G
E
-----
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
------
Y
G
W
L
---
R
T
E
T
------
G
V
H
R
L
V
R
------
K
S
P
F
D
---
S
G
G
R
--------------------
R
H
T
S
F
S
S
A
F
V
Y
P
E
-------------
V
D
-
D
D
I
-
D
I
E
-
I
N
P
A
D
L
R
I
D
V
Y
-
R
T
S
G
A
G
G
Q
H
V
N
---
R
T
E
---
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-------------------------
I
-----
V
T
Q
C
Q
N
D
R
S
Q
H
K
-
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
L
Y
E
L
E
-
M
Q
K
K
N
A
E
K
-----------
Q
-
A
M
ED
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
--------
L
D
D
-----
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
A
V
L
-
D
G
S
L
D
Q
F
I
-----------
E
A
S
L
K
A
G
L
--------------
32
HHSearch
45.80
27%
-26
- C11 -
2JVA
-
?
A:
[7-101]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
H
-
L
P
D
A
E
I
E
L
T
A
I
-
R
A
Q
G
A
G
G
Q
N
V
N
---
K
V
S
---
S
A
M
H
L
--------------------
R
---------------------
F
DINASS
L
-----
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
---
G
V
------------------------
I
-----
V
L
K
A
Q
Q
Y
R
T
Q
E
Q
-
N
R
A
D
A
-
L
L
R
L
-
S
E
L
I
V
N
A
A
-
K
L
E
H
H
H
H
H
-----------
H
----------------------------------------------------------------------------------------------------
45
Fugue
43.04
13%
16
- C4 -
1CB7
2
GLME_CLOCO
B:
[1-483]
--------------------------
M
E
L
K
N
KKW
T
D
E
E
F
H
K
Q
R
E
E
V
L
Q
Q
W
P
T
G
K
E
V
-
D
-
L
Q
E
A
V
D
-
Y
L
K
K
I
P
A
E
----
K
N
F
A
E
K
L
V
L
-
A
K
K
K
G
I
T
M
A
Q
P
R
A
G
V
AL
L
D
E
H
I
E
L
L
---------
R
Y
L
Q
D
E
-
G
G
A
D
F
L
P
S
T
I
D
A
Y
T
R
Q
N
R
Y
D
E
C
E
N
-
G
I
K
E
S
E
K
A
G
R
SLLNG
F
P
G
V
-
N
F
G
V
K
G
C
R
K
V
L
E
A
V
N
L
P
L
Q
A
R
H
G
T
PDS
R
L
L
A
E
I
I
H
A
G
GWTSNE
G
G
G
I
S
Y
N
V
PYAKNVT
I
E
K
S
L
L
D
W
Q
----
Y
C
D
R
L
-
V
G
F
-----
Y
E
E
Q
G
V
H
I
N
R
E
P
FGPLTGTLVP
P
S
M
S
N
A
V
G
I
T
E
A
L
L
A
A
------------
E
Q
G
V
K
N
I
T
V
G
Y
G
E
-----
C
G
N
M
I
Q
D
I
A
A
L
R
C
L
E
E
------
Q
T
N
E
---
Y
L
K
A
Y
GYND
V
F
V
T
T
V
F
H
Q
WMGGF
P
Q
D
E
S
---
K
A
F
G
--------------------
V
I
V
T
A
T
T
I
A
A
L
A
G
-------------
A
T
-
K
-
V
-
I
V
K
-
T
P
H
E
A
I
G
I
P
T
K
-
E
A
N
A
A
G
I
K
A
T
K
---
M
A
L
---
N
M
L
E
G
--------------------
Q
---------------------
R
------
M
-----
P
-----------------
M
---
S
-------------------------
K
-----
E
L
E
T
E
M
A
V
I
K
A
E
-
T
K
C
I
L
-
D
K
M
F
-
E
L
G
K
G
D
L
A
-
I
G
T
V
K
A
F
E
T
GV
M
D
I
P
FGPS
K
-
Y
N
--
A
G
K
M
M
P
V
R
D
N
L
G
C
V
R
Y
L
E
--------
F
G
N
-----
V
P
F
T
E
E
I
K
N
Y
N
R
E
R
L
Q
E
R
A
K
F
E
G
R
D
V
S
F
-----------
Q
M
V
I
D
D
I
F
A
V
GKG
R
--
L
I
G
R
P
E
40
Fugue
43.02
19%
5
- C7 -
3LRV
3
PRP19_YEAST
A:
[11-343]
----------------------------------------------
A
P
K
W
P
I
L
K
N
L
-
E
-
L
L
Q
A
Q
N
-
Y
S
R
N
-------------------------------------------------------
I
K
T
--------
F
P
Y
K
E
L
N
K
S
M
Y
Y
D
K
W
V
C
-
M
C
R
C
E
D
G
A
L
H
-----
F
T
Q
L
-
K
D
S
K
T
I
T
T
I
T
T
------
P
N
P
R
--
T
-------------------
G
G
--------------
E
H
P
A
I
I
S
R
G
P
CN
R
L
L
L
L
-
Y
P
G
N
Q
I
T
I
L
D
S
K
---------------------------------
T
------------
N
K
V
L
R
E
I
E
V
D
S
A
N
EII
Y
M
Y
G
H
N
T
E
Y
F
I
W
A
D
N
R
G
T
------
I
G
F
Q
---
S
Y
E
D
------
D
S
Q
Y
I
V
H
------
S
A
K
S
D
VEY
S
S
G
V
--------------------
L
H
K
D
S
L
L
L
A
L
Y
----------------------------
S
P
D
G
I
L
D
V
Y
-
N
L
S
S
P
D
Q
A
S
S
R
F
P
V
D
E
E
---
A
K
I
K
E
--------------------
V
---------------------
K
------
F
-----
A
-----------------
D
---
N
GY-----------------------
W
-----
M
V
V
E
C
D
Q
T
V
V
C
F
-
D
L
R
K
D
-
V
G
T
L
-
A
Y
P
T
Y
T
I
G
-
T
V
T
Y
D
I
D
D
-----------
S
-----
G
K
N
M
I
A
Y
S
N
E
S
N
S
L
T
I
Y
K
--------
F
D
K
KTK
N
W
T
K
D
E
E
S
A
L
C
L
A
D
F
T
D
M
D
V
V
C
G
D
--
G
G
I
A
-----------
A
I
L
K
T
N
D
S
F
N
---
I
--
V
A
L
T
P
-
7
PsiBlast_PDB
41.98
32%
-28
- C11 -
2RSM
-
CL065_MOUSE
A:
[43-104]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
E
S
E
L
E
E
Q
F
V
-
K
G
H
G
P
G
G
Q
A
T
N
---
K
T
S
---
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-------------------------
I
-----
V
V
K
C
H
Q
T
R
S
V
D
Q
-
N
R
K
I
A
-
R
K
V
L
-
Q
E
K
V
D
V
F
Y
-
N
S
G
P
S
S
G
-----------------------------------------------------------------------------------------------------------------
47
Fugue
41.94
18%
-2
- C5 -
4TWA
11
SYP_PLAF7
A:
[3-497]
MAITSKKIEN
F
S
D
W
Y
T
Q
V
I
V
K
S
EL
I
E
Y
Y
D
I
S
---
G
C
Y
I
L
R
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
-
E
-
I
K
K
-
L
N
-
V
E
N
S
Y
F
P
L
FVTK
N
K
L
E
K
E
K
N
H
-
I
E
G
--------------
F
S
P
E
V
A
W
V
TKYGDSNLP
E
E
I
A
I
R
-
P
T
S
E
---
T
I
M
Y
S
V
F
P
K
W
I
R
S
Y
R
D
L
P
L
K
L
N
Q
W
N
T
V
V
-----
R
W
E
F
-
K
Q
P
T
P
F
I
R
T
R
E
------
F
L
W
Q
E
G
H
-------------------
T
A
H
KN
E
----------
E
E
A
V
K
L
V
F
----
D
I
L
D
L
-
Y
R
R
-----
W
Y
E
E
---------------------------------
Y
LA
V
P
I
I
K
G
I
K
S
E
G
E
K
F
G
G
A
N
F
T
S
T
A
-----
E
A
F
I
S
E
N
G
R
A
I
Q
A
A
T
S
H
YLGT
N
F
A
K
M
F
KI
E
F
E
D
------
E
N
E
V
K
Q
Y
------
V
H
Q
T
S
---
W
G
C
T
T
R
S
I
G
I
M
I
M
T
HGDDKGLVLP
P
N
V
S
K
Y
K
V
V
I
V
P
I
F
Y
K
TTD
E
N
A
I
H
S
Y
C
K
-
D
-
I
-
E
K
I
-
L
K
N
A
Q
I
N
C
V
Y
D
D
R
A
S
Y
S
P
G
Y
K
F
N
---
H
W
E
L
R
G
I
P
I
R
I
--------------------
E
---------------------
V
------
G
-----
P
-----------------
K
---
D
-------------------------
L
Q
N
N
S
C
V
I
V
R
R
D
N
N
E
K
C
N
V
K
K
E
S
V
-
L
L
E
T
-
Q
Q
M
L
V
D
I
H
-
K
N
L
F
L
K
A
K
-----------
K
-
K
L
--
D
D
S
I
V
Q
V
T
S
F
S
E
V
M
N
A
L
N
K
K
K
M
V
L
A
P
W
C
E
-----
D
I
A
T
E
E
E
I
K
K
E
T
Q
R
L
S
L
T
L
S
G
A
M
K
P
L
C
I
PLDQPPMPPNM
K
C
F
W
S
G
K
P
A
K
---
R
W
C
L
F
G
R
S
Y
31
HHSearch
41.09
25%
-29
- C11 -
2RSM
-
CL065_MOUSE
A:
[4-110]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
S
S
G
K
------
W
G
L
R
L
Q
E
------
K
P
A
L
L
---
F
P
G
---------------------
M
A
A
S
T
V
Q
V
A
G
R
K
D
-------------
Y
P
---
A
-
L
L
P
-
L
N
E
S
E
L
E
E
Q
F
V
-
K
G
H
G
P
G
G
Q
A
T
N
---
K
T
S
---
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-------------------------
I
-----
V
V
K
C
H
Q
T
R
S
V
D
Q
-
N
R
K
I
A
-
R
K
V
L
-
Q
E
K
V
D
V
F
Y
-
N
S
G
P
S
S
G
-----------------------------------------------------------------------------------------------------------------
39
Fugue
40.97
25%
6
- C11 -
1J26
-
ICT1_MOUSE
A:
[1-112]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
G
E
H
-------------
A
K
-
Q
-
A
-
S
S
Y
-
I
P
L
D
R
L
S
I
S
Y
C
-
R
S
S
G
P
G
G
Q
N
V
N
---
K
V
N
---
S
K
A
E
V
--------------------
R
---------------------
F
------
H
-----
L
-----------------
A
---
S
ADWIE
E
P
V
R
Q
K
I
A
L
T
HKNKINKAG
E
L
-----
V
L
T
S
E
S
S
R
Y
Q
F
R
-
N
L
A
E
C
-
L
Q
K
I
-
R
D
M
I
A
E
A
S
-
G
P
S
S
G
-------------------------------------------------------------------------------------------------------------------
34
HHSearch
40.88
35%
12
- C11 -
1J26
-
ICT1_MOUSE
A:
[13-108]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
S
S
Y
-
I
P
L
D
R
L
S
I
S
Y
C
-
R
S
S
G
P
G
G
Q
N
V
N
---
K
V
N
---
S
K
A
E
V
R
F
HLASADWIE
E
P
V
R
Q
K
I
A
L
T
---------------------
H
------
K
NKINK
A
-----------------
G
---
E
-------------------------
L
-----
V
L
T
S
E
S
S
R
Y
Q
F
R
-
N
L
A
E
C
-
L
Q
K
I
-
R
D
M
I
A
E
A
S
-
G
P
S
S
G
-------------------------------------------------------------------------------------------------------------------