@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0363: (2015-11-30 )
MKPKHYPDTISSPDFSSLEKEIIKFWQENKIFEQSVEKRSKDNCFVFYDGPPFANGLPHYGHLLTGFIKDAFARYQTMLQKKVERRFGWDCHGLPAEMGAEKELGISGRTEIEKFGIEKFNNYCRTSVMKFSSEWEKYVNRQARWVDFHNDYKTMDRSFMESVIWAFKQLYDKGLVYESVRVVPYSWACETPLSNFETRLDTAYRKKTSKAVTVAFELLENPQQFKQKCKLLAWTTTPWTLPSNLALAIGKDIEYCAVSVHSSVSFQHVTLESREKETWIPLSRTGMTEEGTETVTEDNEVSLVNNEIYIFAEDYLEKFIGHCEQNNIPYENCNTKLKADDLAGLSYKPLFNYFKGTKNAFRVFIADYVTGEDGTGVVHTAPGFGEEDFYLCQSHDIPAICPIDNSGRFTAEVSDLTGIHVFDTNDAIIKKLKEQGNWFKTEQYIHNYPHCWRTDTPLIYRAMPSWYVAVTKFKERMIELNKRVNWIPTHIRDGQFGKWLERAHDWSISRNRFWGTPIPIWKSDNARYPRVDVYGSIAELERDFNVKVNDLHRPFIDSLTRPNPDDPTGKSIMRRVPDVFDCWFESGSVPFAQVHYPFENKEWFESNFPADFITEYIAQTRGWFYTLFVLSTALFDSEPFKNCICHGVVLDVKGQKLSKRLNNYADPMEVFDKYGSDALRFLMLSGSIVCGGNLFLNKEGSSIRDVLKNVMKPIWNSYHFFTMYANADGIKAEVCKDYKSTIDSYMIFKCFEAVESIQASMSNYNSQEACKILIDFFEVLNNWYIRRSRERFWKSNLDQDKTDAYNVLYTVFYYILRAAVPLLPLITETIWQGLKYKEISVHLADFPQLERYDSELIAKMDLVREICNSALSIRNTFNIRVRQPLGSMTVYHQSSCSFLESKPLSVVIPKFSPVIPMRDTGTQKEKKWSNAEMKTSMNEYQEMIKDEVNVKELKLVNSLEGIASLELKLNFPMLGKRIPDKVKKLVQYVKEGKWKQVDNEQVFLGNESESYIIEKDEYELLLKTNSEYSSVFGDNKGIVILNTALDDALVLEGLARDVVRLIQEARKQADFHISDRIRVIIKTEDEKIKRAINTWGEYIREQTLSLSLEINIEIGDNFYSKEYQDLIVGIELNC
Atome Classification :
(20 SA)
.........10..--------......20........30.....-...40........50........60........70........80........90........100.......110-.........120--.........130.......140.......150-....--...160....---...170.......180.......190......------.200.....--.-----.210.......220.......230.......240..-.....250.......260.......270.......280....-...290.......300.......310.......320-.......330.......340.......350....----...360.......370.......380.......390--------.......---..---400----....--------...-------------------------..410----------------------.--.--......420.......430.......440.......450...-....460.......470-........----480--.......490.......500.......510.......520-.........530.-..----.-----.....540.....---..---550.--......560-.......-.-570-......-----..580.......590------.------......----600--.......-----..610.......620-----........630...-....640.......650-----------------------.....------------------....660.......670.......680.......690...--....700.......710.......720.....-.--.730..---.--.....740.......750.......760.......770..-.-.-.-.-.-780.......790....-..-.800........810.......820.......830.------...-.-----..840.......850-.......----.----860....---...870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKPKHYPDTISSP--------
D
F
S
S
L
E
K
E
I
I
K
F
W
Q
EN
K
I
F
E
Q
S
V
-
E
KRSKD
N
C
F
V
F
YDGPPFANGLP
H
Y
G
H
L
L
T
G
F
I
K
D
A
F
A
R
Y
Q
T
M
L
Q
K
K
V
E
R
RFGWDCHGL
P
A
EMGAEKELGISG
R
T
---
E
I
E
K
F
G
I
E
K
F
----
N
N
Y
C
R
T
S
V
M
K
F
S
S
E
W
E
K
Y
V
N
RQ
A
R
W
V
D
FHN
D
Y
-
K
T
M
D
--
R
S
F
M
E
S
V
I
W
A
---
F
K
Q
L
Y
DKGL
V
Y
E
S
V
R
V
V
P
Y
S
W
ACETP
L
S
N
F
E
T
------
R
L
D
T
A
Y
R
KK--T-----S
K
A
V
T
V
A
F
E
L
LE
N
P
Q
Q
F
K
Q
KC
K
L
L
A
WTTTPWTLPS
N
-
L
A
L
A
IGKD
I
E
Y
C
A
V
S
VHSS
V
S
F
Q
H
V
T
LESREKET
W
I
PLSRTG-MTEEGTETVTEDN
E
V
S
L
VN
N
E
I
Y
I
F
A
E
D
Y
L
E
K
F
I
G
H
-
C
EQNNIPYENCNTKLKADDLAGL
S
Y
K
P
L
F
N
Y
F
KG----TK
N
A
F
R
V
F
I
A
D
Y
VTGEDGT
G
V
V
HTAPGFGEE
D
F
Y
----------
L
CQSHDI---
P
A
---
I
------
C
PID--------NSG-------------------------
R
F
T
A
-----------------------
E
--V--SD
L
T
G
I
H
V
FDT
N
D
A
I
I
K
K
L
K
EQGNW
F
K
T
E
Q
Y
I
H
NYPHCWRTD-TP
L
I
Y
RAMP
S
W
Y
V
A
V
T
--
K
F
K
E
R
M
I
E
----
L
NK--RVNWIPTHIRDG
Q
F
G
K
W
L
E
R
AHDWSISRNRFWGTPI
P
I
---WKSDNARYPR--
V
-
D
V
----
Y
-----
G
S
I
A
E
L
E
R
DFN
V
K
---VN---DL
H
R
--
P
F
I
D
S
LTR--PNPDDP
T
-
G
-
K
S
--
I
M
R
RV
P
-----
D
V
F
D
C
W
F
ESGSV
P
F
A
------
Q
------
V
H
YPFE----N----
K
E
W
F
ESN-----F
P
A
D
F
I
T
E
Y
I
A
QTR------GW
F
Y
T
L
F
V
L
S
T
A
LF-DS
E
P
F
K
N
C
ICH
G
V
V
L-------------------------DVK
G
Q
------------------
K
L
S
K
R
L
NNYA
D
P
M
E
V
F
D
KYG
S
D
A
L
R
F
L
M
LS
G
S
I
V
CG
G
N
L
F
--LNKEG
S
S
I
R
D
V
L
K
N
V
M
K
P
I
WNS
Y
H
F
F
T
M
Y
ANA-D--G
I
-
K
A
E
---
V
--
C
K
D
Y
K
S
T
I
D
S
Y
M
I
F
K
C
F
E
A
V
E
S
I
Q
A
S
M
SNY
N
S
Q
E
A
C
K
I
L
I
-
D
-
F
-
F
-
E
-
V
-
L
N
N
W
Y
I
R
R
S
R
E
R
F
W
K
SN-LD-QD-K
T
D
A
Y
N
V
L
Y
T
V
F
Y
Y
I
L
R
A
AV
P
L
L
P
L
I
T
E
T
I
WQG------L
K
Y
-
K
-----
E
I
S
V
H
LAD
F
P
Q
L
E
R
--
Y
D
S
E
L
I
A
----
K
----
M
D
L
V
R
E
I
---
C
N
S
A
L
SIR
N
T
F
N
I
R
VRQPLG
S
M
T
V
Y
HQSSCSFLESK
P
L
S
V
V
IPKFSPVIPMRDTGT
Q
K
E
KKWSN
A
E
M
K
T
S
M
N
E
Y
Q
E
M
I
K
DEV
N
V
K
E
L
K
L
V
N
S
LEG
I
A
S
L
E
L
K
LNFPMLGKRI
P
D
K
V
K
K
L
V
Q
Y
V
KEGKWKQVDNE
Q
V
F
LGNESE
S
Y
I
I
EKD
E
Y
E
L
L
L
KTNS
E
Y
S
S
VFGDNK
G
I
V
I
L
NTALD
D
A
L
V
L
E
G
L
A
R
D
V
V
R
L
I
Q
E
A
R
K
QADFHIS
D
R
I
R
V
I
I
KTE
D
E
K
I
K
R
A
I
N
T
W
G
E
Y
I
R
E
QT
L
S
L
S
L
E
I
N
I
E
IGDNF
Y
S
K
E
Y
Q
D
L
I
V
G
I
E
LNC
43
HHSearch
98.96
39%
-93
- C1 -
1ILE
2
SYI_THET8
A:
[5-821]
---------
V
G
E
P
--------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
-
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
G
L
K
S
K
R
---
E
I
E
A
Y
G
I
E
R
F
----
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
-
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
---
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
------
A
L
--
G
Y
K
E
I
--
Q
-----
D
P
S
V
Y
V
R
F
P
L
K
E
P
K
K
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
-
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
G
---------------------------------------------
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
-
G
------
T
Q
V
L
K
-
T
F
P
G
K
A
L
E
G
L
P
Y
T
P
P
Y
P
Q
A
L
------
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
---
P
L
---
L
------
K
T
V
D
--------
E
E
G
-------------------------
K
L
L
V
-----------------------------
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
-
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
R
----
N
N
Q
--
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
Q
--
A
C
G
K
--
E
-
E
A
----
I
-----
G
S
F
Q
E
L
K
A
R
A
T
K
P
LPE
P
F
---
D
P
H
R
--
P
Y
V
D
Q
V
E
L
--
A
C
-
A
----
C
-
G
G
--
T
M
R
R
V
P
-----
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
------
S
------
L
H
Y
P
F
E
----
H
----
E
E
V
F
R
E
S
-----
F
P
A
D
F
I
A
E
G
I
D
Q
T
R
------
G
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
-
P
P
E
A
D
R
R
--
F
G
P
N
L
--
V
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
-
D
--
R
P
-
D
L
K
---
N
PP
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
-
D
-
F
-
V
-
V
E
D
-
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
-
D
A
-
L
D
-
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
------
L
V
R
-
S
VRLEA
K
E
S
V
H
L
A
D
W
P
E
A
D
P
AL
A
D
E
A
L
V
A
----
Q
----
M
R
A
V
L
K
V
---
V
D
L
A
R
A
A
R
A
K
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.65
37%
-89
- C1 -
1ILE
2
SYI_THET8
A:
[5-816]
---------
V
G
E
P
--------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
-
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
G
L
K
S
K
R
---
E
I
E
A
Y
G
I
E
R
F
----
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
-
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
---
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
------
A
L
--
G
Y
K
E
I
--
Q
-----
D
P
S
V
Y
V
R
F
P
L
K
E
P
K
K
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
-
V
A
A
A
V
H
P
E
Y
T
Y
A
A
--------
F
Q
-------------------------------------
V
G
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
-
G
T
Q
-------
V
L
K
T
F
P
G
K
A
L
E
G
L
P
Y
T
P
--
P
Y
P
Q
A
----
L
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
---
P
L
---
L
------
K
T
V
D
--------
E
E
G
-------------------------
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
-
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
R
----
N
N
Q
--
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
Q
A
C
G
--
K
--
E
-
E
A
----
I
-----
G
S
F
Q
E
L
K
A
R
A
T
K
P
---
L
P
EPF
D
P
H
R
--
P
Y
V
D
Q
V
E
L
--
A
C
----
A
-
C
-
G
G
--
T
M
R
R
V
P
-----
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
------
S
------
L
H
Y
P
F
E
----
H
----
E
E
V
F
R
E
S
-----
F
P
A
D
F
I
A
E
G
I
D
Q
T
R
------
G
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
-----
G
P
N
L
V
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
-
D
RP
D
L
-
K
N
P
---
P
--
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
-
D
-
F
V
V
-
E
-
D
-
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
-
D
A
-
L
D
-
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
LVRSVR
L
E
A
-
K
-----
E
-
S
V
H
L
A
D
W
P
E
A
D
P
AL
A
D
E
A
L
V
A
----
Q
----
M
R
A
V
L
K
V
---
V
D
L
A
R
A
A
R
A
K
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.44
37%
-89
- C1 -
1JZQ
3
SYI_THET8
A:
[5-816]
---------
V
G
E
P
--------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
-
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
G
L
K
S
K
R
---
E
I
E
A
Y
G
I
E
R
F
----
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
-
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
---
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
------
A
L
--
G
Y
K
E
I
--
Q
-----
D
P
S
V
Y
V
R
F
P
L
K
E
P
K
K
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
-
V
A
A
A
V
H
P
E
Y
T
Y
A
A
--------
F
Q
-------------------------------------
V
G
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
-
G
T
Q
-------
V
L
K
T
F
P
G
K
A
L
E
G
L
P
Y
T
P
--
P
Y
P
Q
A
----
L
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
---
P
L
---
L
------
K
T
V
D
--------
E
E
G
-------------------------
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
-
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
R
----
N
N
Q
--
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
Q
A
C
G
--
K
--
E
-
E
A
----
I
-----
G
S
F
Q
E
L
K
A
R
A
T
K
P
---
L
P
EPF
D
P
H
R
--
P
Y
V
D
Q
V
E
L
--
A
C
----
A
-
C
-
G
G
--
T
M
R
R
V
P
-----
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
------
S
------
L
H
Y
P
F
E
----
H
----
E
E
V
F
R
E
S
-----
F
P
A
D
F
I
A
E
G
I
D
Q
T
R
------
G
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
-----
G
P
N
L
V
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
-
D
RP
D
L
-
K
N
P
---
P
--
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
-
D
-
F
V
V
-
E
-
D
-
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
-
D
A
-
L
D
-
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
LVRSVR
L
E
A
-
K
-----
E
-
S
V
H
L
A
D
W
P
E
A
D
P
AL
A
D
E
A
L
V
A
----
Q
----
M
R
A
V
L
K
V
---
V
D
L
A
R
A
A
R
A
K
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.95
37%
-89
- C1 -
1JZS
3
SYI_THET8
A:
[5-816]
---------
V
G
E
P
--------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
-
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
G
L
K
S
K
R
---
E
I
E
A
Y
G
I
E
R
F
----
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
-
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
---
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
------
A
L
--
G
Y
K
E
I
--
Q
-----
D
P
S
V
Y
V
R
F
P
L
K
E
P
K
K
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
-
V
A
A
A
V
H
P
E
Y
T
Y
A
A
--------
F
Q
-------------------------------------
V
G
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
-
G
T
Q
-------
V
L
K
T
F
P
G
K
A
L
E
G
L
P
Y
T
P
--
P
Y
P
Q
A
----
L
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
---
P
L
---
L
------
K
T
V
D
--------
E
E
G
-------------------------
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
-
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
R
----
N
N
Q
--
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
Q
A
C
G
--
K
--
E
-
E
A
----
I
-----
G
S
F
Q
E
L
K
A
R
A
T
K
P
---
L
P
EPF
D
P
H
R
--
P
Y
V
D
Q
V
E
L
--
A
C
----
A
-
C
-
G
G
--
T
M
R
R
V
P
-----
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
------
S
------
L
H
Y
P
F
E
----
H
----
E
E
V
F
R
E
S
-----
F
P
A
D
F
I
A
E
G
I
D
Q
T
R
------
G
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
-----
G
P
N
L
V
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
-
D
RP
D
L
-
K
N
P
---
P
--
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
-
D
-
F
V
V
-
E
-
D
-
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
-
D
A
-
L
D
-
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
VRSVR
L
E
A
-
K
-----
E
-
S
V
H
L
A
D
W
P
E
A
D
P
AL
A
D
E
A
L
V
A
----
Q
----
M
R
A
V
L
K
V
---
V
D
L
A
R
A
A
R
A
K
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
84.48
27%
-76
* C1 *
1FFY
4
SYI1_STAAU
A:
[9-864]
-
M
P
K
T
D
--
F
P
M
R
G
--------
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
-
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
I
E
Q
A
L
T
K
K
-
G
V
D
R
-------
K
K
M
S
T
A
E
F
----
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
-
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
---
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
Y
H
D
K
--
R
-----
S
A
S
I
Y
V
A
F
N
V
K
D
D
K
G
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
-
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
N
---------------------------------------------
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
-
I
K
L
E
K
-
E
Y
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
L
D
---------
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
---
P
V
---
I
------
S
P
I
D
--------
D
K
G
-------------------------
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
-
K
P
V
I
F
R
A
T
P
Q
W
F
A
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--
K
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----
A
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--
N
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---
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G
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-
I
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-----
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H
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-
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L
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-----
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------
V
------
L
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R
--------------
P
E
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-----
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P
A
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M
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------
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W
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-
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-------------------------
D
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------------------
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L
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----
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---
N
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-
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I
A
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N
D
K
------------------------------------
F
N
A
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A
L
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L
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C
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D
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L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
--------------------------------------------------------------------------------------------------------------------------
64
Fugue
83.10
25%
-67
- C1 -
1QU2
5
SYI1_STAAU
A:
[1-917]
---
M
D
Y
E
K
T
L
L
M
P
KTDFPMRG
G
L
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N
K
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---
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---
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---------------------------------------------
N
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---
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-------------------------
V
F
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-----------------------
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--
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---
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----
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----
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-----------
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D
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K
S
L
G
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V
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A
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I
S
---
D
E
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---
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L
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T
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W
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------
T
P
H
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K
-----
E
E
S
V
H
L
A
D
M
P
K
V
V
E
--
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D
Q
A
L
L
D
----
K
----
W
R
T
F
M
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L
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D
D
V
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R
A
L
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T
A
R
N
E
K
V
I
G
K
S
L
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A
K
V
T
I
A
S
N
D
K
------------------------------------------
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
-------------------------------------------
Q
V
K
V
V
D
K
L
D
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Q
A
T
A
Y
E
H
G
D
I
V
I
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H
----------------------------------------------------------
A
D
G
E
K
C
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R
C
W
N
Y
S
E
D
L
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D
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L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
---------------
5
PsiBlast_PDB
82.43
26%
-73
- C1 -
1QU3
2
SYI1_STAAU
A:
[24-817]
--------------------------
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
-
E
K
N
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G
N
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G
P
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Y
A
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G
W
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G
L
P
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G
V
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R
K
-------
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M
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A
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----
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L
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---
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G
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S
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L
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A
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------
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----
Y
H
D
K
--
R
-----
S
A
S
I
Y
V
A
F
N
V
K
D
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K
G
V
V
D
A
D
A
K
F
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W
T
I
P
S
N
-
V
A
I
T
V
H
P
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L
K
Y
G
Q
Y
N
---------------------------------------------
V
N
G
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K
Y
I
I
A
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-----
A
L
S
D
-
A
V
A
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A
L
D
W
D
K
A
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C
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----------
V
G
Q
Q
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---
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---
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------
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P
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--------
D
K
G
-------------------------
V
F
T
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-----------------------
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--
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--
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M
F
Y
D
K
A
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N
T
N
F
--
K
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N
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K
T
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I
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N
-----
M
V
R
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R
G
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Q
R
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W
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---
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-----
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-
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-----
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G
S
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------
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------
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----
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----
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----
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--
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L
S
-----
F
P
A
D
M
Y
L
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G
S
D
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Y
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------
G
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
-------------------------
D
G
E
G
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
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Q
K
G
A
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M
L
G
N
I
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D
F
N
--
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--
S
I
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---
L
--
L
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-----
V
D
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Y
L
L
N
R
L
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T
A
S
T
I
N
N
Y
E
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F
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Y
L
N
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Y
Q
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V
Q
-
N
-
F
-
I
-
N
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V
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S
N
F
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D
I
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Q
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H
I
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M
Q
T
V
L
Y
Q
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L
V
D
M
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K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
------
T
P
H
V
K
-----
E
E
S
V
H
L
A
D
M
P
K
V
V
E
--
V
D
Q
A
L
L
D
----
K
W
R
T
F
M
N
L
R
D
D
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---
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
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A
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A
S
N
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K
F
N
A
S
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F
L
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A
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Q
V
K
V
V
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K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.27
26%
-73
- C1 -
1FFY
4
SYI1_STAAU
A:
[24-817]
--------------------------
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
-
E
K
N
K
G
N
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L
H
D
G
P
P
Y
A
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G
N
L
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A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
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F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
I
E
Q
A
L
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K
K
-
G
V
D
R
K
-------
K
M
S
T
A
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F
----
R
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K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
-
I
T
L
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--
P
E
Y
E
A
A
Q
I
R
I
---
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
------
E
----
Y
H
D
K
--
R
-----
S
A
S
I
Y
V
A
F
N
V
K
D
D
K
G
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
-
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
---------------------------------------------
V
N
G
E
K
Y
I
I
A
E
-----
A
L
S
D
-
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
-
Y
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
----
L
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
---
P
V
---
I
------
S
P
I
D
--------
D
K
G
-------------------------
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
-
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
--
K
V
N
W
G
K
T
R
I
Y
N
-----
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
N
G
E
I
I
M
--
T
K
E
T
----
V
-----
N
H
V
A
D
L
F
A
E
H
G
S
N
---
I
W
----
F
E
R
--
E
A
K
D
L
L
P
E
GF
T
H
P
G
S
P
N
-
G
-----
T
F
T
K
E
T
-----
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
------
V
------
L
----
E
----
T
----
R
P
--
E
L
S
-----
F
P
A
D
M
Y
L
E
G
S
D
Q
Y
R
------
G
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
-------------------------
D
G
E
G
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
D
V
R
I
S
D
E
I
L
K
Q
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
--
P
D
T
-
D
--
S
I
P
E
S
E
---
L
--
L
E
-----
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
-
N
-
F
-
I
-
N
-
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
-
R
D
-
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
------
T
P
H
V
K
-----
E
E
S
V
H
L
A
D
M
P
K
V
V
E
--
V
D
Q
A
L
L
D
----
K
W
R
T
F
M
N
L
R
D
D
V
---
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.27
26%
-73
- C1 -
1QU2
4
SYI1_STAAU
A:
[24-817]
--------------------------
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
-
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
I
E
Q
A
L
T
K
K
-
G
V
D
R
K
-------
K
M
S
T
A
E
F
----
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
-
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
---
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
------
E
----
Y
H
D
K
--
R
-----
S
A
S
I
Y
V
A
F
N
V
K
D
D
K
G
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
-
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
---------------------------------------------
V
N
G
E
K
Y
I
I
A
E
-----
A
L
S
D
-
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
-
Y
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
----
L
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
---
P
V
---
I
------
S
P
I
D
--------
D
K
G
-------------------------
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
-
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
--
K
V
N
W
G
K
T
R
I
Y
N
-----
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
N
G
E
I
I
M
--
T
K
E
T
----
V
-----
N
H
V
A
D
L
F
A
E
H
G
S
N
---
I
W
----
F
E
R
--
E
A
K
D
L
L
P
E
GF
T
H
P
G
S
P
N
-
G
-----
T
F
T
K
E
T
-----
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
------
V
------
L
----
E
----
T
----
R
P
--
E
L
S
-----
F
P
A
D
M
Y
L
E
G
S
D
Q
Y
R
------
G
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
-------------------------
D
G
E
G
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
D
V
R
I
S
D
E
I
L
K
Q
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
--
P
D
T
-
D
--
S
I
P
E
S
E
---
L
--
L
E
-----
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
-
N
-
F
-
I
-
N
-
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
-
R
D
-
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
------
T
P
H
V
K
-----
E
E
S
V
H
L
A
D
M
P
K
V
V
E
--
V
D
Q
A
L
L
D
----
K
W
R
T
F
M
N
L
R
D
D
V
---
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
80.27
22%
-63
- C1 -
1GAX
3
SYV_THETH
A:
[1-862]
------
M
D
L
P
K
A
Y
--------
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
F
V
---
A
-
N
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
L
K
E
G
K
T
---
R
-
H
D
L
G
R
E
K
F
----
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
-
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
---
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
----------
V
E
T
E
P
T
--
P
-----
G
K
L
Y
T
L
R
Y
E
V
E
G
G
G
-------
F
I
E
I
A
T
V
R
P
E
T
V
F
A
D
-
Q
A
I
A
V
H
P
E
---------------------------------------------
D
E
R
Y
R
H
L
L
G
K
R
A
R
I
---------------------------------------------
P
L
----
T
E
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
---
K
P
---
V
------
S
V
I
N
--------
L
E
G
-------------------------
R
M
E
G
-----------------------
E
--
R
VP
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
-
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
----
G
L
R
R
G
D
I
A
F
V
P
E
R
-
W
K
K
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
D
C
Q
-------
A
V
----
N
-----
V
P
R
P
E
R
Y
L
-------------------------
E
D
--
P
T
S
C
E
A
C
-
G
-
S
P
--
R
L
K
R
D
E
-----
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
------
T
------
L
G
W
P
-
E
----
E
----
T
E
D
L
K
A
F
-----
Y
P
G
D
V
L
V
T
G
Y
D
I
L
F
------
L
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
-
G
Q
D
I
R
--
L
D
---
L
R
W
L
E
M
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
-
F
--
Q
A
-
K
---------
E
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
-
E
-
L
-
V
-
W
-
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
--------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
------
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
E
E
A
E
R
----
A
----
F
E
A
L
K
Q
A
---
V
T
A
V
R
A
L
K
A
E
A
G
L
P
-------------------
P
A
Q
E
V
R
V
Y
L
E
G
----------------------
E
T
A
P
V
E
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
-
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
------------------------
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----------------------------------------------------------------
42
HHSearch
79.69
24%
-83
- C1 -
1GAX
3
SYV_THETH
A:
[2-745]
-------
D
L
P
K
A
Y
--------
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
-
F
V
A
N
---
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
L
K
E
-
G
K
---
T
R
H
D
L
G
R
E
K
F
----
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
-
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
---
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
T
E
P
T
--
P
-----
G
K
L
Y
T
L
R
Y
E
V
E
G
-------
G
G
F
I
E
I
A
T
V
R
P
E
T
V
F
A
D
-
Q
A
I
A
V
H
P
E
D
E
R
----------------------------------------------------------------------------
Y
---------
R
H
L
L
G
K
R
A
R
I
P
L
T
E
---------
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
---
K
P
---
V
------
S
V
I
N
--------
L
E
G
-------------------------
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
-
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
----
G
L
R
R
G
D
I
A
F
V
P
E
R
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
--
D
C
Q
A
--
V
-
N
V
----
P
-----
R
P
E
---------------------
R
--
Y
L
E
--
D
P
T
--
S
C
E
A
----
C
-
G
S
P-
R
L
K
R
D
E
-----
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
------
T
------
L
G
W
P
E
E
----
T
-----
E
D
L
K
A
F
-----
Y
P
G
D
V
L
V
T
G
Y
D
I
L
F
------
L
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
-------------------------
D
E
K
G
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
-
T
G
G
Q
D
I
R
--
L
D
L
R
W
--
L
E
M
A
R
N
-
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
-----
G
F
-
Q
A
K
-------
E
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
-
E
-
L
V
W
-
S
-
E
-
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
--------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
------
L
T
G
-------
K
E
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
E
E
A
E
R
----
A
----
F
E
A
L
K
Q
A
---
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
76.04
21%
-78
- C1 -
1WZ2
-
SYL_PYRHO
A:
[4-866]
------------
L
--------
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
-
R
D
K
P
K
E
K
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
I
V
G
I
A
E
R
I
K
N
R
D
P
K
T
I
W
I
Y
R
D
V
Y
K
V
P
E
E
I
L
W
T
F
E
D
P
I
N
I
V
K
Y
F
M
K
A
A
K
E
T
F
I
R
A
G
F
S
V
D
W
S
R
E
F
-
Y
T
T
S
LF
P
P
F
S
K
F
I
E
W
Q
---
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
------
M
E
---
G
E
D
V
P
-
I
-----
L
D
Y
I
I
I
K
F
E
L
R
E
N
G
----
E
V
I
Y
L
P
A
A
T
L
R
P
E
T
V
Y
G
V
-
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
-----------------------------------------
K
D
K
E
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
-
D
R
---
E
-
I
E
V
I
E
-
E
F
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
S
G
---------
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
ALEDL
K
R
E
T
E
I
L
E
K
Y
D
I
---
D
P
R
I
V-----------FPAVEEVN
K
L
G
IKSQKDKEKLEQATK
T
I
Y
K
A
E
YHK
G
I
F
K
---------------------------
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
M
L
E
K
G
I
A
E
I
M
Y
E
F
A
E
K
N
V
I
S
-
R
F
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
G
N
P
E
W
K
E
K
A
R
K
----
A
L
E
--
R
M
K
I
L
P
E
T
R
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
A
C
A
R
K
I
G
L
G
T
P
L
P
W
DPE
W
V
I
E
S
L
S
D
S
T
--
I
-
Y
M
----
A
Y
----
Y
T
I
S
R
-----------------------
H
I
N
K
L
-----
R
-
Q
----
E
-
G
K
LD
P
E
K
L
T
P
-----
E
F
F
D
Y
I
F
L
E
E
F
S
E
D
K
E
K
E
L
E
K
K
------
T
G
I
P
A
E
----
I
I
H
E
M
K
E
E
F
E
Y
W
-----
Y
P
L
D
W
R
C
S
G
K
D
L
I
P
------
N
H
L
T
F
F
I
F
N
H
V
A
I
F
R
E
E
H
W
P
K
G
I
A
V
N
G
F
G
T
-------------------------
L
-
E
G
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
M
S
L
A
-
E
H
D
S
D
F
D
--
W
R
R
K
E
--
V
G
K
L
R
K
-
Q
I
E
R
F
Y
E
L
I
S
Q
F
A
E
Y
E
-------
V
-
K
G
--------
N
V
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
Y
S
-
I
-
M
-
N
-
D
-
L
-
R
W
Y
L
R
R
T
E
G
--
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
------
L
G
G
-------
E
G
F
V
S
L
A
K
W
P
E
P
V
E
EW
W
N
E
T
I
E
A
----
E
----
E
E
F
I
R
S
V
---
M
E
D
I
K
E
I
I
E
V
A
K
I
E
---
N
A
K
R
A
Y
I
Y
T
A
E
D
W
K
W
K
V
A
E
V
V
S
E
K
R
D
F
K
S
S
M
E
E
L
M
K
D
S
E
I
R
K
H
G
K
E
V
A
K
I
V
Q
K
L
I
K
E
R
T
F
D
V
K
R
I
N
E
E
K
A
L
R
E
A
K
E
F
M
E
K
E
L
G
I
E
I
I
I
N
P
T
E
D
K
G
G
K
K
K
Q
A
M
P
L
K
P
A
I
F
I
E
--------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
74.96
21%
-74
- C1 -
1WKB
8
SYL_PYRHO
A:
[4-810]
------------
L
--------
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
-
R
D
K
P
K
E
K
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
I
V
G
I
A
E
R
I
K
N
R
D
P
K
T
I
W
I
Y
R
D
V
Y
K
V
P
E
E
I
L
W
T
F
E
D
P
I
N
I
V
K
Y
F
M
K
A
A
K
E
T
F
I
R
A
G
F
S
V
D
W
S
R
E
F
-
Y
T
T
S
LF
P
P
F
S
K
F
I
E
W
Q
---
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
----------
M
E
G
E
D
V
P
I
-----
L
D
Y
I
I
I
K
F
E
L
R
E
N
G
----
E
V
I
Y
L
P
A
A
T
L
R
P
E
T
V
Y
G
V
-
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
-----------------------------------------
K
D
K
E
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
-
D
R
---
E
-
I
E
V
I
E
-
E
F
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
S
G
---------
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
A
L
E
D
L
K
R
E
TE
I
L
E
K
Y
D
I
---
D
P
---
R
IVFPAV
E
E
V
N
--------
K
L
G
-------------------------
I
K
S
Q
KDKEK
L
E
Q
A
T
K
T
I
Y
K
A
E
Y
H
K
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
M
L
E
K
G
I
A
E
I
M
Y
E
F
A
E
K
N
V
I
S
R
F
G
N
-
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
G
N
P
E
W
K
E
K
A
R
K
----
A
L
E
--
R
M
K
I
L
P
E
T
R
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
A
C
A
R
K
I
G
L
G
T
P
L
P
W
DPE
W
V
I
E
--
S
L
S
D
S
T
I
-
Y
M
----
A
Y
Y
T
I
S
R
H
I
N
K
L
R
Q
E
-
G
K
---------------------------------
L
-
D
---
P
E
K
L
T
P
-----
E
F
F
D
Y
I
F
L
E
E
F
S
E
D
K
------
E
K
E
L
E
K
K
T
G
I
P
A
E
I
I
H
E
M
----
K
E
E
F
E
Y
W
-----
Y
P
L
D
W
R
C
S
G
K
D
L
I
P
------
N
H
L
T
F
F
I
F
N
H
V
A
I
F
R
E
E
H
W
P
K
G
I
A
V
N
G
F
G
T
-------------------------
L
-
E
G
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
M
S
L
A
-
E
H
D
S
D
F
D
--
W
R
R
K
E
--
V
G
K
L
R
K
-
Q
I
E
R
F
Y
E
L
I
S
Q
F
A
E
Y
E
V
--------
K
G
--------
N
V
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
-
Y
S
I
-
M
-
N
-
D
-
L
-
R
W
Y
L
R
R
T
E
G
--
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
------
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.98
21%
-58
- C1 -
4AQ7
3
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
N
E
Q
V
IDGCCW
R
C
D
T
K
V
E
R
K
--
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
T
K
V
A
E
A
E
M
A
T
M
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
N
I
K
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
ET
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAGHELVYTGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.68
21%
-56
- C1 -
3ZGZ
2
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
N
E
Q
V
IDGCCW
R
C
D
T
K
V
E
R
K
--
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
T
K
V
A
E
A
E
M
A
T
M
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
NIK
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
ET
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAGHELVYTGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.47
21%
-58
- C1 -
4CQN
3
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
N
E
Q
V
IDGCCW
R
C
D
T
K
V
E
R
K
--
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
T
K
V
A
E
A
E
M
A
T
M
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
NIK
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
E
T
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVDAI
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAGHELVYTGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.15
21%
-63
- C1 -
3ZJU
1
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
--------------------------------
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
T
----------
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
N
I
K
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
E
T
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAG
H
E
L
V
Y
TGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.76
21%
-64
- C1 -
4ARI
4
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
--------------------------------
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
T
----------
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
N
I
K
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
E
T
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAG
H
E
L
V
Y
TGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.37
21%
-62
- C1 -
3ZJV
-
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
K
Y
Y
C
L
S
M
L
---
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
-------------------------
N
N
---
T
A
P
A
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
--
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
--------------------------------
E
I
P
Q
W
F
I
K
I
T
A
Y
A
D
E
L
L
N
D
L
D
------
K
L
D
H
W
P
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
D
N
T
L
T
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
A
G
H
P
L
A
Q
K
A
A
E
N
N
P
E
------------------
L
A
A
F
I
D
E
-
C
R
---------
N
---------
T
M
E
K
K
G
V
D
T
G
F
K
A
V
HPL
T
G
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
A
S
K
Y
G
L
N
I
K
P
V
---
I
------
L
A
A
D
--------
G
S
---------------------------------------------------------------------
E
P
D
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
------------
N
G
L
D
H
E
A
A
---
F
N
A
I
A
--
D
K
L
T
A
M
G
V
----
G
E
R
--
K
V
N
Y
---------------
R
L
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
T
L
E
D
---------------------
G
T
V
M
P
T
P
D
D
-
Q
L
P
---
V
I
---
L
P
E
D
--
V
V
M
D
G
I
T
S
--
P
I
K
A
D
P
E
W
A
-
K
T
--
T
V
N
G
M
P
A
L
R
ET
D
T
F
D
T
F
M
E
S
-
S
W
Y
Y
A
------
R
------
Y
T
C
P
Q
Y
----
K
----
E
G
M
L
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
H
A
I
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVDAI
V
E
R
D
E
K
G
R
IV
K
A
K
D
AAG
H
E
L
V
Y
TGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
---
P
A
D
M
T
--
L
E
W
Q
E
S
G
V
E
G
A
-
N
R
F
L
K
R
V
W
K
L
V
Y
E
H
T
A
K
G
D
V
-
A
--
A
L
-
N
V
D
---
A
--
L
T
E
N
Q
K
A
L
-
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
-------
I
-
M
-
E
-
L
-
M
N
---------
K
L
A
K
A
P
-
T
D
-
G
E
-
Q
D
R
A
--
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
------
L
K
G
-
E
-----
G
D
I
D
N
A
P
W
P
V
A
D
E
K
--
A
M
V
E
D
S
T
----
L
----
V
V
V
Q
V
N
G
---
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.27
21%
-62
- C1 -
3ZJT
1
SYL_ECOLI
A:
[30-797]
-------------------------
I
E
S
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