@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0621: (2015-12-03 )
MSYIQILPETFSIISSLVLLLLGIVFNRRTINLLALGCTVITLIILILSAKDSGFFPFNSLLKLDLYIRSAQGLILIAGILVLLLLNLSKYDYEYEFSILILFTLFGMITLVSANNLISFYLSFELMSIPLYVLASFNKDSVYSCEAGVKYFTLSALSSCIMLYGMSLLYGYTGLVNFSELSSFLENHQMTYGIVFGLVLILIGLCFKLAIAPFHMWAPDVYQGAPTIVTAFFSTVPKAALVTFLIRFFMGEELVGVEKYFQPVLLYISALSVLISAFGALRQRNLKRLLAYSSIGHIGFILASLSIFTRMGTDSSLIYLVIYIITNIGLFSYFIQIDDDDCSVANLSGIGKKRPVLAFHLSILLFSMAGIPPLAGFFAKLFIFKSLVNSGFIGMSLIFIVASVISCYYYLSIIKAMYFDKPSDSKVIYSKSLFIVTSVASLINIVLFMCVEDLYSLIHLVTKSL
Atome Classification :
(20 SA)
---.........10........20........-----30.-.......40........50.----------.......60.....-----...70........80.....--...90-----.---....------....100......---------..110.......120.......130.......140---........150..-.....160....-..----.170...--.....180......--.190.--...-...200.......210.......220.......230..-.....240........250.......260.-......270..-.....280.......290.......300.....-..--310.....-..320-..--....--.330.......-----340.........350.......360-.......370.-.-.....380.-......390-...-------.....400.......410---........420..-..--...-----430..----------.......440...-----....450--........460...---------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
S
Y
I
Q
I
L
P
E
T
F
S
I
I
S
S
L
V
L
L
L
L
G
I
V
FNR
R
-----
T
I
N
-
L
L
A
L
G
C
T
V
I
T
L
I
I
L
I
LSAKD----------SGFF
P
F
N
S
L
L
K
L
D
L
-----
Y
I
RSAQ
G
L
I
L
I
A
G
I
L
V
L
L
L
L
--NLSK------Y---
D
Y
E
Y
------
E
F
S
I
L
I
-
L
F
T
L
F
G
---------
M
I
T
L
VSANN
L
I
S
F
Y
L
S
F
E
L
M
S
I
P
L
Y
V
L
A
SFNKD
S
----
V
Y
SCEAG
V
K
Y
F
T
L
-
S
A
L
S
S
C
I
M
L
Y
G
M
-
S
L
----
L
Y
-GYTG--LV
N
F
S
E
L
S
S
F
L
E
NH--Q
M
T
Y
G
--
I
V
F
-
G
L
V
L
I
L
I
G
L
C
F
K
L
A
IA
P
F
HMWA
P
D
V
YQG
A
P
T
I
V
T
A
F
F
S-TV
P
K
A
A
-
L
V
T
F
L
I
R
F
F
MG
E
E
L
V
G
V
E
K
Y
F
Q
P
-
V
L
L
Y
I
S
A
L
S
V
L
-
I
S
A
F
G
A
L
R
Q
R
N
L
K
R
L
L
A
Y
SSI
G
H
I
G
F
I
L
A
S
L
S
I
-
F
T
--RMGTD
S
S
L
-
I
Y
L
V
I
-
Y
I
--
I
TNI--G
L
F
S
Y
F
I
Q
IDD-----D--DCSVANLSGIGKKRP
V
L
A
F
H
L
S
-
I
L
L
F
S
MAGI
P
P
-
L
-
A
G
F
F
A
K
L
F
I
-
F
K
S
L
V
NSG--
F
I
G
-------
M
S
L
I
F
I
V
A
S
V
I
S
C
Y
Y
Y
L
----
S
I
I
K
A
M
YFDKPSD-S
K
--
V
I
Y
-----
S
--KS----------
L
F
I
V
T
S
V
A
S
L
I
N
I
-----
V
L
F
M
C
V
---
E
D
L
Y
S
L
I
H
L
V
TKSL---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.78
30%
-168
- C7 -
3RKO
4
?
N:
[20-480]
------------------
T
V
V
V
V
M
L
S
I
A
W
R
R
N
HFLNA
T
L
S
-
V
I
G
L
N
A
A
L
V
S
L
W
F
V
----
G
Q
----------
A
G
A
M
D
V
T
P
L
M
R
V
D
G
-----
F
A
M
L
Y
T
G
L
V
L
L
A
S
L
A
T
C
T
F
A
YP
W
L
E
G
------
Y
N--
D
N
K
D
------
E
F
Y
L
L
V
-
L
I
A
A
L
G
---------
G
I
L
L
A
N
A
N
H
L
A
S
L
F
L
G
I
E
L
I
S
L
P
L
F
G
L
V
G
Y
A
F
R
Q
----
K
R
S
L
E
A
S
I
K
Y
T
I
L
-
S
A
A
A
S
S
F
L
L
F
G
M
-
A
L
----
V
Y
-
A
Q
S
G
--
D
L
S
F
V
A
L
G
K
---------
N
E
P
--
L
L
L
A
G
F
G
L
M
I
V
G
L
G
F
K
L
S
L
V
P
F
H
L
W
T
P
D
V
Y
Q
G
A
P
A
P
V
S
T
F
L
A
-
T
A
S
K
I
A
-
I
F
G
V
V
M
R
L
F
L
Y
A
P
-
V
G
D
S
E
A
I
R
V
-
V
L
A
I
I
A
F
A
S
I
I
-
F
G
N
L
M
A
L
S
Q
T
N
I
K
R
L
L
G
Y
S
S
I
S
H
L
G
Y
L
L
V
A
L
I
A
-
L
Q
TG
E
M
S
M
E
A
V
G
-
V
Y
L
A
G
-
Y
L
--
F
S
S
L
--
G
A
F
G
V
V
S
L
M
S
S
PYRGP
D
--
A
D
S
L
F
S
Y
R
G
L
F
W
H
R
P
I
L
A
A
V
M
T
-
V
M
M
L
S
L
A
G
I
P
M
-
T
-
L
G
F
I
G
K
F
Y
V
-
L
A
V
G
V
Q
A
H
--
L
W
W
-------
L
V
G
A
V
V
V
G
S
A
I
G
L
Y
Y
Y
L
----
R
V
A
V
S
L
Y
L
H
A
P
E
Q
P
S
N
--
W
Q
Y
-----
S
--
A
G
-----------
G
I
V
V
L
I
S
A
L
L
V
L
-----
V
L
G
V
W
P
---
Q
P
L
I
S
I
V
R
L
A
M
P
L
M
---------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
95.47
31%
-162
- C7 -
3RKO
4
?
N:
[7-484]
----
N
L
I
A
L
L
P
L
L
I
V
G
L
T
V
V
V
V
M
L
S
I
A
W
R
R
N
H
-----
F
L
N
A
T
L
S
V
I
G
L
N
A
A
L
V
S
L
W
F
-
V
G
Q
----------
A
G
A
M
D
V
T
P
L
M
R
V
D
G
-----
F
A
M
L
Y
T
G
L
V
L
L
A
S
L
A
T
C
T
F
A
Y-
P
-
W
L
------
E
GYN
D
N
K
D
------
E
F
Y
L
L
V
-
L
I
A
A
L
G
---------
G
I
L
L
A
N
A
N
H
L
A
S
L
F
L
G
I
E
L
I
S
L
P
L
F
G
L
V
G
Y
A
F
R
Q
----
K
R
S
L
E
A
S
I
K
Y
T
I
L
-
S
A
A
A
S
S
F
L
L
F
G
M
-
A
L
----
V
Y
-
A
Q
S
G
--
D
L
S
F
V
A
L
G
K
-------
N
-
E
P
L
--
L
L
A
-
G
F
G
L
M
I
V
G
L
G
F
K
L
S
L
V
P
F
H
L
W
T
P
D
V
Y
Q
G
A
P
A
P
V
S
T
F
L
A
-
T
A
S
K
I
A
-
I
F
G
V
V
M
R
L
F
L
Y
A
-
P
V
G
D
S
E
A
I
R
V
-
V
L
A
I
I
A
F
A
S
I
I
-
F
G
N
L
M
A
L
S
Q
T
N
I
K
R
L
L
G
Y
S
S
I
S
H
L
G
Y
L
L
V
A
L
I
A
-
L
Q
TG
E
M
S
M
E
A
V
G
-
V
Y
L
A
G
-
Y
L
--
F
S
S
L
--
G
A
F
G
V
V
S
L
M
S
S
PYRGP
D
--
A
D
S
L
F
S
Y
R
G
L
F
W
H
R
P
I
L
A
A
V
M
T
-
V
M
M
L
S
L
A
G
I
P
M
-
T
-
L
G
F
I
G
K
F
Y
V
-
L
A
V
G
V
Q
A
H
--
L
W
W
-------
L
V
G
A
V
V
V
G
S
A
I
G
L
Y
Y
Y
L
----
R
V
A
V
S
L
Y
L
H
A
P
E
Q
-
P
------------SN
W
Q
YSA-------
G
G
I
V
V
L
I
S
A
L
L
V
L
-----
V
L
G
V
W
P
---
Q
P
L
I
S
I
V
R
L
A
M
P
L
M
---------------------------------------------------------------------------------------------------------------------------------
14
Fugue
78.64
18%
-160
- C7 -
3RKO
4
?
B:
[1-612]
MNM
L
A
L
T
I
I
L
P
L
I
G
F
V
L
L
A
F
S
R
G
R
W
S
E
N
V
S
A
I
-----
V
G
V
-
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
N
GE
Q
T
Y
S
Q
P
LW
T
W
M
S
V
G
D
F
N
I
G
F
N
L
-----
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
--
H
M
Y
A
------
S
---
W
Y
M
R
GEEG
Y
S
R
F
F
A
Y
T
-
N
L
F
I
A
S
---------
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
Y
T
D
----
P
K
N
G
A
A
A
M
K
A
F
V
V
-
T
R
V
G
D
V
F
L
A
F
A
L
-
F
I
----
L
Y
-
N
E
L
G
--
T
L
N
F
R
E
M
V
E
L
A
P
A
H
--
F
A
D
G
N
N
M
L
M
W
-
A
T
L
M
L
L
G
G
A
V
G
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
A
G
-
P
T
P
V
S
A
L
I
H
-
A
A
T
M
V
T
-
A
G
V
Y
L
I
A
R
T
--
H
G
L
F
L
M
T
P
E
V
L
H
-
L
V
G
I
V
G
A
V
T
L
L
-
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
Q
A
W
--
D
A
A
I
F
H
L
M
-
T
H
A
F
F
-
K
A
--
L
L
F
L
--
A
S
G
S
V
I
L
A
C
H
H
-----
E
--
Q
-
N
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
-
V
G
G
A
A
L
S
A
L
P
L
-
V
T
A
G
F
F
S
K
D
E
I
-
L
A
G
A
M
A
N
G
--
H
I
N
-------
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
----
R
M
I
F
I
V
F
H
G
K
E
Q
--
I
H
--
A
H
A
-----
V
--
K
G
----------
V
T
H
S
L
P
L
I
V
L
L
I
L
-----
S
T
F
V
G
A
---
L
I
V
P
P
L
Q
G
V
L
P
Q
T
T
ELAH
G
S
M
L
T
L
E
I
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
WLGKR
T
L
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
AWG
F
D
W
L
Y
D
K
VF
V
K
P
F
L
G
I
A
W
L
L
KRD
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
LSENGY
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
2
PsiBlast_PDB
78.55
36%
-159
- C7 -
4HE8
-
NQO14_THET8
N:
[81-390]
--------------------------------------------------------------------------------------------------------------------------------
R
F
------
E
F
Y
L
L
V
-
L
Y
A
A
L
G
---------
M
H
L
L
A
S
T
R
H
L
L
L
M
L
V
A
L
E
A
L
S
L
P
L
Y
A
L
A
T
W
R
R
G
Q
------
G
L
E
A
A
L
K
Y
F
L
L
-
G
A
L
A
A
A
F
F
L
Y
G
A
-
A
L
----
F
Y
-
G
A
T
G
---------
S
L
V
L
G
A
P
--
G
E
G
P
L
--
Y
A
L
-
A
L
G
L
L
L
V
G
L
G
F
K
A
A
L
A
P
F
H
F
W
T
P
D
V
Y
Q
G
S
P
T
P
V
V
L
F
M
A
-
T
S
V
K
A
A
-
A
F
A
A
L
L
R
V
A
A
P
P
E
-----------
A
L
A
L
L
V
A
L
S
V
V
-
V
G
N
L
A
A
L
A
Q
K
E
A
K
R
L
L
A
Y
S
S
I
A
H
A
G
Y
M
--
A
L
A
L
-
Y
T
----
G
N
A
Q
A
L
G
F
Y
L
L
T
-
Y
V
--
L
A
T
G
--
L
A
F
A
V
L
S
Q
I
S
P
-----
D
--
R
V
P
L
E
A
L
R
G
L
Y
R
K
D
P
L
L
G
L
A
F
L
-
V
A
M
L
S
L
L
G
L
P
P
-
L
-
A
G
F
W
G
K
Y
L
A
-
F
A
E
A
A
R
A
G
--
A
W
G
-------
V
L
V
L
A
L
V
T
S
A
V
S
A
Y
Y
Y
L
----
G
L
G
L
A
V
-
F
A
R
P
E
E
-
T
P
--
F
R
P
-----
G
--
P
P
----------
W
A
R
A
A
V
V
A
A
G
V
L
L
-----
L
A
L
G
L
L
---
P
G
L
V
L
P
A
L
A
A
G
G
-----------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
78.14
20%
-159
- C7 -
3RKO
5
?
M:
[79-493]
------------------------------------------------------------------------------
I
H
L
A
I
D
G
-----
L
S
L
L
M
V
V
L
T
G
L
L
G
V
L
A
V
L
C
S
W-
K
-
E
I
------
E
---
K
Y
Q
G
------
F
F
H
L
N
L
-
M
W
I
L
G
G
---------
V
I
G
V
F
L
A
I
D
M
F
L
F
F
F
F
W
E
M
M
L
V
P
M
Y
F
L
I
A
L
W
G
H
K
ASDG
K
T
R
I
T
A
A
T
K
F
F
I
Y
-
T
Q
A
S
G
L
V
M
L
I
A
I
-
L
A
LVFV
H
Y
-
N
A
T
G
VW
T
F
N
Y
E
E
L
L
N
T
P
M
----
S
-
S
G
V
--
E
Y
L
-
L
M
L
G
F
F
I
A
F
A
V
K
M
P
V
V
P
L
H
G
W
L
P
D
A
H
S
Q
A
P
T
A
G
S
V
D
L
A
-
G
I
L
L
K
T
-
A
A
Y
G
L
L
R
F
S
L
P
L
-
F
P
N
A
S
A
E
F
A
P
-
I
A
M
W
L
G
V
I
G
I
F
-
Y
G
A
W
M
A
F
A
Q
T
D
I
K
R
L
I
A
Y
T
S
V
S
H
M
G
F
V
L
I
A
I
Y
T
-
G
S
--
Q
L
A
Y
Q
G
A
V
-
I
Q
M
I
A
-
H
G
--
L
S
A
A
--
G
L
F
I
L
C
G
Q
L
Y
E
RI---
H
--
T
R
D
M
R
M
M
G
G
L
W
S
K
M
K
W
L
P
A
L
S
L
-
F
F
A
V
A
T
L
G
M
P
G
-
T
-
G
N
F
V
G
E
F
M
I
-
L
F
G
S
F
Q
V
V
--
P
-
V
-------
I
T
V
I
S
T
F
G
L
V
F
A
S
V
Y
S
L
----
A
M
L
H
R
A
Y
F
G
K
A
K
S
-
Q
I
--
A
S
Q
ELPGM
S
--
L
R
----------
E
L
F
M
I
L
L
L
V
V
L
L
V
-----
L
L
G
F
Y
P
---
Q
P
I
L
D
T
S
H
S
A
I
G
N
I
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.79
36%
-160
- C7 -
4HEA
-
NQO14_THET8
N:
[81-390]
--------------------------------------------------------------------------------------------------------------------------------
R
F
------
E
F
Y
L
L
V
-
L
Y
A
A
L
G
---------
M
H
L
L
A
S
T
R
H
L
L
L
M
L
V
A
L
E
A
L
S
L
P
L
Y
A
L
A
T
W
R
R
G
Q
------
G
L
E
A
A
L
K
Y
F
L
L
-
G
A
L
A
A
A
F
F
L
Y
G
A
-
A
L
----
F
Y
-
G
A
T
G
---------
S
L
V
L
G
A
P
--
G
E
G
P
L
--
Y
A
L
-
A
L
G
L
L
L
V
G
L
G
F
K
A
A
L
A
P
F
H
F
W
T
P
D
V
Y
Q
G
S
P
T
P
V
V
L
F
M
A
-
T
S
V
K
A
A
-
A
F
A
A
L
L
R
V
A
A
P
P
E
-----------
A
L
A
L
L
V
A
L
S
V
V
-
V
G
N
L
A
A
L
A
Q
K
E
A
K
R
L
L
A
Y
S
S
I
A
H
A
G
Y
M
--
A
L
A
L
-
Y
T
----
G
N
A
Q
A
L
G
F
Y
L
L
T
-
Y
V
--
L
A
T
G
--
L
A
F
A
V
L
S
Q
I
S
P
-----
D
--
R
V
P
L
E
A
L
R
G
L
Y
R
K
D
P
L
L
G
L
A
F
L
-
V
A
M
L
S
L
L
G
L
P
P
-
L
-
A
G
F
W
G
K
Y
L
A
-
F
A
E
A
A
R
A
G
--
A
W
G
-------
V
L
V
L
A
L
V
T
S
A
V
S
A
Y
Y
Y
L
----
G
L
G
L
A
V
-
F
A
R
P
E
E
-
T
P
--
F
R
P
-----
G
--
P
P
----------
W
A
R
A
A
V
V
A
A
G
V
L
L
-----
L
A
L
G
L
L
---
P
G
L
V
L
P
A
L
A
A
G
G
-----------------------------------------------------------------------------------------------------------------------------------
15
Fugue
76.64
18%
-167
- C7 -
4HE8
1
NQO13_THET8
G:
[1-467]
--------
M
V
V
L
A
V
L
L
P
V
V
F
G
A
L
L
L
--
L
G
L
P
R
-----
A
L
G
-
V
L
G
A
G
L
S
F
L
L
N
L
Y
L
F
L
T
H
P
G
----------
G
V
A
H
A
F
Q
A
P
L
L
P
G
A
-----
G
V
Y
W
A
F
G
L
D
G
L
S
A
L
F
F
L
T
I
A
--
L
T
V
F
------
L
---
G
A
L
V
ARVEG-
R
F
L
G
L
A
-
L
L
M
E
G
L
---------
L
L
G
L
F
A
A
R
D
L
L
V
F
Y
V
F
F
E
A
A
L
I
P
A
L
L
M
L
Y
L
Y
G
G
E
-----
G
R
T
R
A
L
Y
T
F
V
L
F
-
T
L
V
G
S
L
P
M
L
A
A
V
-
L
G
----
A
R
-
L
L
S
G
--
S
P
T
F
-
L
L
E
D
L
L
A
H
P
--
L
Q
E
E
A
--
A
F
W
-
V
F
L
G
F
A
L
A
F
A
I
K
T
P
L
F
P
L
H
A
W
L
P
P
F
H
Q
E
N
H
P
S
G
L
A
D
A
L
-
G
T
L
Y
K
V
-
G
V
F
A
F
F
R
F
A
I
P
L
-
A
P
E
G
F
A
Q
A
Q
G
-
L
L
L
F
L
A
A
L
S
A
L
-
Y
G
A
W
V
A
F
A
A
K
D
F
K
T
L
L
A
Y
A
G
L
S
H
M
G
V
A
A
L
G
V
F
S
-
G
T
--
P
E
G
A
M
G
G
L
-
Y
L
L
A
A
-
S
G
--
V
Y
T
G
--
G
L
F
L
L
A
G
R
L
Y
E
-----
R
TG
T
L
E
I
G
R
Y
R
G
L
A
Q
S
A
P
G
L
A
A
L
A
L
-
I
L
F
L
A
M
V
G
L
P
G
-
L
-
S
G
F
P
G
E
F
L
T
-
L
L
G
A
Y
K
A
S
--
P
W
L
-------
A
A
L
A
F
-
L
S
V
I
A
S
A
A
Y
A
L
----
T
A
F
Q
K
T
F
W
E
E
G
G
S
-
G
V
--
K
D
L
-----
A
--
G
A
----------
E
W
G
F
A
L
L
S
V
L
A
L
L
-----
L
M
G
V
F
P
---
G
Y
F
A
R
G
L
H
P
L
A
E
A
F
AKLLGG---------------------------------------------------------------------------------------------------------------------------
6
HHSearch
74.52
22%
-162
- C7 -
3RKO
4
?
L:
[75-444]
----------------------------------------------------------------------------
I
G
F
N
L
V
L
D
G
-----
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S-
W
-
Y
M
RG----
E
---
E
G
Y
S
------
R
F
F
A
Y
T
-
N
L
F
I
A
S
---------
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
Y
T
D
----
P
K
N
G
A
A
A
M
K
A
F
V
V
-
T
R
V
G
D
V
F
L
A
F
A
L
-
F
I
----
L
Y
-
N
E
L
G
--
T
L
N
F
R
E
M
V
E
L
A
P
A
H
FA
D
G
N
N
M
--
L
M
W
-
A
T
L
M
L
L
G
G
A
V
G
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
A
-
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
-
G
V
Y
L
I
A
R
T
H
G
L
F
-
L
M
--
T
P
E
V
L
H
-
L
V
G
I
V
G
A
V
T
L
L
-
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
-
Q
-----
A
W
D
A
A
I
-
F
H
L
M
T
-
H
A
--
F
F
K
A
--
L
L
F
L
A
S
G
S
V
I
L
ACH--
H
--
E
Q
N
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
-
V
G
G
A
A
L
S
A
L
P
L
V
T
-
A
G
F
F
S
K
D
E
I
-
L
A
G
A
M
A
N
G
--
H
I
N
-------
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
----
R
M
I
F
I
V
F
H
G
K
E
Q
I
-
H
A
--
H
A
V
-----
K
--
G
V
----------
T
H
S
L
P
L
I
V
L
L
I
L
S
-----
T
F
V
G
A
L
---
I
V
P
P
L
Q
G
V
L
P
Q
T
T
E
---------------------------------------------------------------------------------------------------------------------------------
18
Fugue
59.84
15%
-166
- C4 -
4JS1
3
SIAT1_HUMAN
A:
[1-318]
---------------------------------------------------------------------------
P
E
A
S
F
Q
V
W
N
K
-----
D
S
S
S
K
N
-------
L
I
P
R
L
Q
K
--
I
W
K
N
------
Y
---
L
S
M
N
------
K
Y
K
V
S
---
Y
K
G
P
G
---------
P
G
I
K
F
S
A
E
A
L
R
C
H
L
R
D
H
V
N
V
S
M
V
E
V
T
D
F
P
F
N
T
S
E
----
W
E
G
Y
L
P
K
E
S
I
R
T
K
A
G
P
W
G
R
C
A
V
V
S
S
A
-
G
S
----
L
K
-
S
---------
S
Q
L
G
R
E
I
D
D
H
--
D
------------------
A
V
L
R
F
N
G
A
P
T
A
N
F
Q
Q
D
V
--
G
T
K
T
-------------------
T
I
R
L
M
N
S
Q
L
V
T
T
E
K
R
F
L
K
D
-
S
L
Y
N
E
G
I
L
I
V
W
D
P
S
V
Y
H
S
----
D
I
P
K
W
Y
Q
N
P
D
Y
N
----
F
F
N
N
Y
K
T
-
Y
R
--
K
L
H
P
N
Q
P
F
-
Y
I
L
---------------------------------------------
K
P
Q
M
P
W
E
L
W
-
D
I
L
Q
E
I
S
P
E
E
------------
I
-
Q
P
N
P
P
S
S
G
--
M
L
G
-------
I
I
I
M
M
T
L
C
D
Q
V
D
I
Y
E
F
L
PSKR
K
T
D
V
C
Y
Y
Y
Q
K
F
F
D
-
S
A
--
C
T
M
-----
G
---
A
----------
Y
H
P
L
L
Y
E
K
N
L
V
K
H
-----
L
N
Q
G
T
D
---
E
D
I
Y
L
L
G
K
A
T
L
P
G
F
RTIHC----------------------------------------------------------------------------------------------------------------------------
16
Fugue
58.25
22%
-146
* C4 *
1XIP
-
NU159_YEAST
A:
[1-381]
--A
S
S
L
K
D
E
V
P
T
E
T
S
E
---------------------------
D
F
G
F
K
F
L
G
Q
K
Q
I
L
P
S
F
N
E
----------
K
--
L
P
F
A
S
L
Q
N
L
D
I
S
NSKS
L
F
V
A
A
S
G
S
K
A
V
V
G
E
L
Q
L
L
R
D
--
H
I
T
S
DS
T
P
L
T
F
---
K
W
E
K
------
E
I
P
D
V
I
-
F
V
C
F
H
G
---------
D
Q
V
L
V
S
T
R
N
--------
A
L
Y
S
L
D
L
E
E
L
S
E
F
R
T
V
T
----
S
F
E
----
K
P
V
F
Q
L
-
K
N
V
N
N
--
T
L
V
I
L
-
N
S
----
V
N
-
D
L
S
A
--
L
D
L
R
T
K
S
T
K
Q
L
A
Q
N
--
V
T
S
F
D
--
V
T
N
-
S
Q
L
A
V
L
L
K
D
------
R
S
F
Q
S
F
A
W
R
------------------
N
G
E
M
E
K
Q
F
E
F
S
L
P
S
E
L
E
E
L
P
V
E
E
Y
-
S
P
-
L
S
V
T
I
L
S
P
Q
D
F
-
L
A
V
F
G
N
V
I
S
E
-------------------------------
T
D
D
E
V
-
S
Y
D
Q
K
M
Y
I
--
I
K
H
I
--
D
G
S
A
S
F
Q
E
T
F
D
---------------------------------------
I
T
P
-
P
-
F
G
Q
I
V
R
F
P
Y
M
Y
K
V
T
L
S
G
L
--
I
E
P
-------
D
A
N
V
N
V
L
A
S
--
S
C
S
S
E
V
----
S
I
W
D
S
K
Q
V
I
E
P
S
Q
-
D
S
E
R
A
V
L
-----
P
--
I
S
EETD
K
D
T
N
P
I
G
V
A
V
D
V
V
T
S
G
L
P
L
-----
V
Y
I
L
N
N
---
E
G
S
L
Q
I
V
G
L
F
H
------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
57.56
17%
-144
* C5 *
4OC8
4
?
A:
[2-388]
------
T
F
F
T
G
E
T
L
G
Q
V
D
----
L
I
V
D
A
V
Y
A
G
Y
-----
K
T
E
-
R
---
G
G
M
A
D
P
L
V
P
L
V
G
V
S
R
Q
----------
G
G
F
R
Y
R
G
T
R
E
R
--------------------
P
T
L
L
V
L
T
S
--
N
L
A
E
------
P
---
E
W
P
D
------
Q
L
D
E
T
T
G
T
F
I
Y
Y
G
DNRHPGRLL
H
D
T
P
R
F
G
N
Q
L
L
R
Q
I
F
D
W
A
H
L
G
Q
R
H
L
V
P
P
-----------------
I
L
V
F
T
T
-
E
A
T
G
R
T
F
R
F
R
G
L
-
A
V
----
P
-----
G
--
S
P
A
L
A
A
T
E
D
L
V
A
L
W
--
K
T
T
E
G
--
Q
R
F
-
Q
N
Y
K
A
V
F
T
I
-
L
D
E
A
V
I
P
-
R
A
W
V
H
A
V
G
R
G
E
T
-------
S
-
G
L
A
P
V
A
-
W
N
A
W
L
S
A
G
-------
G
I
R
P
L
M
A
P
R
S
L
L
V
R
S
K
A
E
Q
L
-
P
A
--
T
P
E
D
Q
A
L
I
E
V
I
R
Q
R
Y
K
E
N
P
F
G
F
E
A
C
A
G
A
L
-
T
R
--
L
L
L
P
D
V
A
R
-
L
D
L
----------------
T
R
P
W
R
D
G
G
-----
R
--
D
-------
G
I
G
R
L
R
I
---------------
G
Q
S
P
-
A
-
A
I
E
V
D
F
A
L
E
-
A
K
C
Y
G
A
N
N
--
A
V
G
-------
V
K
E
V
S
R
L
I
S
R
I
K
H
R
E
F
G
----
V
L
V
T
T
S
Y
V
D
R
Q
A
Y
-
Q
E
--
V
T
D
-----
D
--
G
H
----------
P
V
I
L
T
T
A
Q
D
I
V
G
L
-----
L
R
S
A
G
V
RT
P
T
Q
V
D
A
W
L
D
G
I
T
A
S
V
---------------------------------------------------------------------------------------------------------------------------------
22
Fugue
53.94
19%
-156
- C2 -
4FDW
19
?
A:
[21-401]
---
A
S
L
E
D
F
S
I
E
Q
---
L
P
A
K
T
I
Y
A
L
G
E
N
I
D
L
T
-----
G
L
N
-
V
T
G
K
Y
D
D
G
K
Q
R
P
V
K
V
T
S
E
Q
I
----------
S
G
F
-------
S
S
S
V
-----
P
V
D
K
Q
E
V
T
I
T
I
E
G
K
Q
K
S
F
S
V
--
H
I
S
P
------
V
---
R
V
E
N
------
G
---
V
L
-
T
E
I
L
K
G
---------
Y
N
E
I
I
L
P
N
S
V
-----------------
K
S
I
P
K
D
A
--------------
F
R
N
-
S
Q
I
A
K
V
V
L
N
E
G
L
K
S
I
----
G
D
M
A
F
F
N
S-
T
V
Q
E
I
V
F
P
S
T
L
E
----
Q
L
K
E
D
--
I
F
Y
-
Y
--------
C
Y
N
L
K
K
A
D
L
S
--------------
K
T
K
I
T
-
K
L
P
A
S
T
-
F
V
Y
-----------
A
G
I
E
E
V
L
L
P
-
V
T
L
K
------
E
-
I
G
S
Q
A
F
L
K
T
S
Q
L
K
T
I
E
I
P
E
N
V
S
T
I
G
-------------
Q
E
A
F
R
E
S
G
-
I
T
T
V
K
-
L
P
NG
V
T
N
I
AS
R
A
F
Y
Y
C
P
E
L
A
-----------
E
V
T
T
Y
G
S
T
F
N
D
D
P
E
-----
A
M
I
H
P
Y
C
L
E
G
C
P
K
-
L
-
A
R
F
E
I
P
E
S
I
---
R
I
L
G
Q
G
--
L
L
G
GNRKVT
Q
L
T
I
P
A
N
V
T
Q
I
N
F
S
A
F
N
N
----
T
G
I
K
E
V
K
V
E
G
T
T
P
-
P
Q
--
V
-
F
-----
E
--
K
V
----------
W
Y
G
F
P
D
D
I
T
V
I
R
V
P
AES
V
E
K
Y
K
N
A
---
N
G
W
R
D
F
T
N
K
I
T
T
F
----------------------------------------------------------------------------------------------------------------------------------
19
Fugue
50.98
15%
-139
- C5 -
4UPC
-
NICA_HUMAN
A:
[42-655]
---
I
P
L
N
K
T
A
P
C
V
C
Q
S
S
I
S
G
D
T
G
V
I
H
V
V
E
K
E
E
-----
D
L
Q
-
W
V
L
T
D
G
P
N
P
P
Y
M
V
L
L
E
S
K
H
F
----------
T
-----
R
D
L
M
E
-
K
L
-----
K
G
R
T
S
R
--------
I
A
A
V
S
L
--
T
K
P
S
------
P
---
A
S
G
F
------
S
P
N
G
L
A
-
Y
E
D
F
S
F
---------
P
I
F
L
L
E
D
E
N
E
T
K
V
I
N
L
S
Q
N
G
S
C
A
M
Q
L
F
S
H
M
T
A
T
C
----
M
R
R
S
S
I
Q
S
T
F
S
I
V
-
C
D
P
L
S
D
Y
N
V
W
S
M
-----------------
L
N
V
V
V
A
A
T
R
L
D
S
R
--
S
F
F
W
N
--
V
A
P
-
G
A
E
S
A
V
A
S
F
V
T
Q
L
A
A
A
E
A
L
Q
K
A
P
D
V
T
T
L
P
R
N
V
M
F
V
F
F
Q
-
G
E
T
F
D
Y
-
I
--
G
S
S
R
M
V
Y
D
M
E
K
G
P
V
S
Q
K
N
E
S
-
V
R
L
E
K
S
G
A
G
V
----
P
A
V
I
L
R
R
P
N
Q
S
Q
P
L
P
P
R
A
R
N
I
S
G
V
V
L
A
D
H
S
--------
G
A
F
H
N
K
-
Y
Y
Q
S
I
-
Y
D
--
T
A
E
N
--
I
N
V
S
Y
P
E
W
L
S
P
-----
E
--
E
----
D
L
N
F
V
T
D
T
A
K
A
L
A
D
V
A
T
-
V
L
G
R
A
L
Y
E
D
T
V
-
Q
-
A
D
P
Q
T
V
T
L
L
-
Y
G
F
L
I
K
P
L
QH
Y
I
A
-------
V
-
V
Q
Y
A
L
A
N
L
T
G
T
V
V
N
L
----
C
V
R
S
T
A
R
L
A
R
A
W
S
-
S
T
----------
E
--
Y
S
----------
T
W
T
E
S
R
W
--------------------
K
D
I
R
A
R
I
F
L
--------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
34.91
19%
-5
- C7 -
3RKO
-
NUOK_ECOBD
K:
[12-48]
---------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
L
F
V
L
G
---------
L
T
G
L
V
I
R
R
N
L
L
F
M
L
I
G
L
E
I
M
I
N
A
S
A
L
A
F
V
V
A
G
S
Y
----
W
G
Q
T
D
G
Q
V
M
Y
I
L
A
-
I
S
L
A
A
A
E
A
S
I
G
L
-
A
L
----
L
L
-
Q
L
H
R
--
R
R
Q
N
L
N
I
D
S
V
S
E
M
R
--
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
34.61
64%
708
- C7 -
2L3I
-
A:
[11-24]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
K
Q
R
V
L
K
R
L
L
A
M
L
R
Q
H
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
27.46
26%
291
* C6 *
3OBQ
1
TS101_HUMAN
A:
[69-91]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
P
I
C
L
W
L
L
D
T
Y
P
Y
N
P
P
I
C
F
V
K
P
T
-
S
S
M
T
I
K
-
T
G
K
H
V
D
A
N
G
K
I
Y
L
P
Y
L
H
E
W
K
H
P
Q
-
S
D
L
L
G
L
I
Q
V
M
I
-
V
V
F
G
D
E
P
P
V
F
S
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
25.17
30%
412
* C7 *
1WNN
-
?
A:
[1-23]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
A
Q
R
Q
A
R
L
L
R
M
S
A
Y
A
A
K
R
Q
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
22.81
33%
535
- C6 -
3R3Q
-
STP22_YEAST
A:
[81-98]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
I
P
V
I
M
W
V
P
S
M
Y
P
V
K
P
P
F
I
S
I
N
L
E
-
N
F
D
M
N
T
-
I
S
S
S
L
P
I
Q
E
Y
I
D
S
N
G
W
I
A
L
P
I
L
H
-
A
W
D
P
A
A
M
N
L
I
M
-
V
V
Q
E
L
M
S
L
L
H
E
P
P
Q
D
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
14.31
11%
580
- C3 -
3KV0
-
?
A:
[138-155]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
R
V
T
L
-
P
H
H
S
F
L
V
-
P
I
F
S
A
A
M
S
A
C
P
Y
R
D
-
F
Y
A
L
G
D
-
D
E
Q
V
Q
E
E
L
R
E
Y
L
V
A
L
D
I
V
N
I
L
R
F
-
L
E
S
E
A
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
11.70
21%
873
- C6 -
2P08
-
?
A:
[9-22]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
P
F
H
F
A
F
S
R
N
R
E
I
V
Q
T
G
E
V
L
E
R
I
-
S
P
E
P
L
V
-
G
K
L
I
E
Q
H
F
Q
I
N
R
P
K
I
L
I
D
F
D
A
I
S
-
K
Q
P
R
A
L
F
I
L
E
F
-
L
H
N
G
M
Q
L
K
G
Q
M
M
Y
Q
P
E
E
E
V
I
F
F
L
G
S
P
W
I
T
D
T
T
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------