@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0629: (2015-12-03 )
MVGAVQIKKTGGPEVLEFIDKSIGEPKGEEVLIRHTAIGLNRYDLEHRKGVRKIKGLPSVLGVEAVGVIEKLGKKIDDSLQIGDRVGYCTAPPGAYCEKRVIHQKYLVKIPDEIPDEVVAAVLFKGMTAHYLINQSYKIKPGAFVLVHGANGGLGQIICQWAKDKKGVVIGSVSSDKKMEVALQNGCTYAINYNDKNFVSKIMEITQNRGVGAVYDPIGYSTSRLSFESLSKFGIYVSYGQISGIAPVSFSLLSSRSLFATGTSIYHYKRDRFALVLTAMEIFEMVKKKLLTVRINKKYKFDEIIKAHHDMENRKVSGLNIIKVF
Atome Classification :
(20 SA)
.........10...-.....20........30........40........50---....-...----..60........70.....-----...80...----------...---..90-------------------------..-------.......100-..-.....110...-..---.-.--120.---......130.......140.......150.......160.....-..170.......180.......190....--...200.......210.......220.......--230.......240..-..-...250......-.-..260-...------....--270---------.......280.......290..--.--....300.......310..-.....320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
G
A
V
Q
I
KKTG
G
P
E
-
V
L
E
F
I
D
K
S
IGEPKG
E
E
V
L
I
R
H
TAIGLNRY
D
L
E
H
R
K
G
----
V
R
K
I
-KGL----
P
S
V
L
G
V
E
A
V
G
V
I
E
K
L
G
K
KI-----DDSLQIGD----------RVG---YCT--------------------------AP-------
P
G
A
Y
C
E
K
R
V
I
-
H
Q
-
K
Y
L
V
KIPDEI
P
-
D
E
---
V
-
V
--
A
A
V
L
---
F
KGM
T
A
H
Y
L
INQ
S
Y
K
IKP
G
A
F
V
L
V
HGANG
G
L
G
Q
I
I
C
Q
WAKDKK
G
-
V
V
I
G
SVSSD
K
K
M
E
V
A
LQNG
C
T
Y
A
I
NYN
D
K
--
N
F
V
S
K
I
M
E
I
T
QNRGVG
A
V
YDPIGYSTSRL
S
F
E
S
--
L
SKF
G
I
Y
V
S
YGQISG-IA-
P
V
S
F
--
S
L
LSSR-S-
L
F
ATG-
T
S
I
------
Y
H
YK--R
D
R
---------
F
A
L
V
L
T
A
M
E
I
F
E
M
V
K
KK
L
L
T
V
R
--I--NKKY
K
F
D
E
I
I
K
A
HHDMENR-KVSG
L
N
I
I
K
VF
1
PsiBlast_PDB
93.66
36%
-105
- C1 -
1WLY
-
CAA43_BURSP
A:
[2-325]
-
V
M
A
A
V
I
H
K
K
G
G
P
D
-
N
F
V
W
E
E
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
------------
P
----
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
-----
T
D
-
F
T
V
G
E
----------
R
V
C
---
T
C
L
--------------------------
P
P
-------
L
G
A
Y
S
Q
E
R
L
Y
-
P
A
-
E
K
L
I
K
V
P
K
D
L
D
L
D
D
---
V
H
L
--
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
-
T
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
--
D
F
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
I
G
K
D
T
L
Q
K
S
L
D
C
--
L
R
P
R
G
M
C
A
A
Y
G
H
A
S
G
-
V
A
D
P
I
R
V
VE
D
L
G
V
R
G
-
S
-
L
F
I
T
R
-
P
A
L
------
W
H
Y
M
--
S
N
R
---------
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
S
S
--
V
--
A
K
T
F
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
R
-
Q
T
I
G
S
I
V
L
L
P
Q
5
PsiBlast_PDB
92.41
34%
-109
- C1 -
4RVS
-
?
A:
[4-323]
---
A
I
E
V
T
E
T
G
G
P
G
-
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
-----
Q
Y
P
-
R
E
L
----
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
TAA--
D
T
A
I
S
V
G
D
----------
R
V
V
---
S
A
S
--------------------------
A
N
--------
G
A
Y
A
E
F
C
T
A
-
P
A
-
S
L
T
A
K
V
P
D
D
V
T
-
S
E
---
V
-
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
--
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
--
Q
R
L
N
A
A
G
S
-
V
Y
L
T
R
-
P
S
L
------
F
H
F
T
--
R
T
G
---------
E
E
F
S
W
R
A
A
E
L
F
D
A
I
G
N
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
T
V
G
S
V
V
L
L
P
-
25
HHSearch
91.59
35%
-106
- C1 -
3JYN
1
?
A:
[1-325]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
-
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
----
L
Y
P
A
-
P
F
L
----
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
------
T
R
F
K
V
G
D
----------
R
V
A
---
Y
G
T
--------------------------
G
P
-------
L
G
A
Y
S
E
V
H
V
L
-
P
E
-
A
N
L
V
K
L
A
D
S
V
S
-
F
E
---
Q
-
A
--
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
--
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
-
P
V
S
G
V
N
L
--
G
I
L
A
Q
K
D
S
-
V
Y
V
T
R
-
P
T
L
------
G
S
Y
A
--
N
N
A
---------
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
T
T
G
S
T
I
L
I
P
-
3
PsiBlast_PDB
90.77
35%
-108
- C1 -
3JYN
1
?
A:
[1-323]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
-
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
----
L
Y
P
A
-
P
F
L
----
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
-----
T
-
R
F
K
V
G
D
----------
R
V
A
---
Y
G
T
--------------------------
G
P
-------
L
G
A
Y
S
E
V
H
V
L
-
P
E
-
A
N
L
V
K
L
A
D
S
V
S
-
F
E
---
Q
-
A
--
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
--
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
P
V
S
-
G
V
N
L
--
G
I
L
A
Q
K
D
S
-
V
Y
V
T
R
-
P
T
L
------
G
S
Y
A
--
N
N
A
---------
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
T
T
G
S
T
I
L
I
P
-
4
PsiBlast_PDB
90.25
34%
-98
- C1 -
4RVU
1
?
A:
[7-326]
---
A
I
E
V
T
E
T
G
G
P
G
-
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
-----
Q
Y
P
-
R
E
L
----
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
--
D
T
A
I
S
V
G
D
----------
R
V
V
---
S
A
S
--------------------------
A
N
--------
G
A
Y
A
E
F
C
T
A
-
P
A
-
S
L
T
A
K
V
P
D
D
V
T
-
S
E
---
V
-
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
--
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
--
Q
R
L
N
A
A
G
S
-
V
Y
L
T
R
-
P
S
L
------
F
H
F
T
--
R
T
G
---------
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
T
V
G
S
V
V
L
L
P
-
6
PsiBlast_PDB
89.89
33%
-108
- C1 -
1QOR
2
QOR1_ECOLI
A:
[2-325]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
-
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
----
L
Y
P
P
-
P
S
L
----
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
-----
K
H
-
I
K
A
G
D
----------
R
V
V
---
Y
A
Q
--------------------------
S
A
-------
L
G
A
Y
S
S
V
H
N
I
-
I
A
-
D
K
A
A
I
L
P
A
A
I
S
-
F
E
---
Q
-
A
--
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
--
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
A
V
T
-
G
V
N
L
--
G
I
L
N
Q
K
G
S
-
L
Y
V
T
R
-
P
S
L
------
Q
G
Y
I
--
T
T
R
---------
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
--
V
A
E
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
-
A
T
Q
G
S
S
L
L
I
P
-
2
PsiBlast_PDB
89.89
35%
-108
- C1 -
3JYL
-
?
A:
[1-323]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
-
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
----
L
Y
P
A
-
P
F
L
----
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
-----
T
-
R
F
K
V
G
D
----------
R
V
A
---
Y
G
T
--------------------------
G
P
-------
L
G
A
Y
S
E
V
H
V
L
-
P
E
-
A
N
L
V
K
L
A
D
S
V
S
-
F
E
---
Q
-
A
--
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
--
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
P
V
S
-
G
V
N
L
--
G
I
L
A
Q
K
D
S
-
V
Y
V
T
R
-
P
T
L
------
G
S
Y
A
--
N
N
A
---------
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
T
T
G
S
T
I
L
I
P
-
22
PsiBlast_CBE
89.27
34%
-102
- C1 -
4RVU
1
?
C:
[7-326]
---
A
I
E
V
T
E
T
G
G
P
G
-
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
-----
Q
Y
P
-
R
E
L
----
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
TAA--
D
T
A
I
S
V
G
D
----------
R
V
V
---
S
A
S
--------------------------
A
N
--------
G
A
Y
A
E
F
C
T
A
-
P
A
-
S
L
T
A
K
V
P
D
D
V
T
-
S
E
---
V
-
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
--
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
--
Q
R
L
N
A
A
G
S
-
V
Y
L
T
R
-
P
S
L
------
F
H
F
T
--
R
T
G
---------
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
T
V
G
S
V
V
L
L
P
-
21
PsiBlast_CBE
89.10
34%
-101
- C1 -
4RVU
1
?
D:
[7-326]
---
A
I
E
V
T
E
T
G
G
P
G
-
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
-----
Q
Y
P
-
R
E
L
----
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
--------
A
I
S
V
G
D
----------
R
V
V
---
S
A
S
--------------------------
A
N
--------
G
A
Y
A
E
F
C
T
A
-
P
A
-
S
L
T
A
K
V
P
D
D
V
T
-
S
E
---
V
-
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
--
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
--
Q
R
L
N
A
A
G
S
-
V
Y
L
T
R
-
P
S
L
------
F
H
F
T
--
R
T
G
---------
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
T
V
G
S
V
V
L
L
P
-
30
HHSearch
88.75
33%
-105
- C1 -
1QOR
2
QOR1_ECOLI
A:
[2-327]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
-
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
----
L
Y
P
P
-
P
S
L
----
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
------
K
H
I
K
A
G
D
----------
R
V
V
---
Y
A
Q
--------------------------
S
A
-------
L
G
A
Y
S
S
V
H
N
I
-
I
A
-
D
K
A
A
I
L
P
A
A
I
S
-
F
E
---
Q
-
A
--
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
--
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
-
A
V
T
G
V
N
L
--
G
I
L
N
Q
K
-
G
S
L
Y
V
T
R
-
P
S
L
------
Q
G
Y
I
--
T
T
R
---------
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
V
A
E
--
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
-
A
T
Q
G
S
S
L
L
I
P
-
24
PsiBlast_CBE
88.56
33%
-109
- C1 -
1QOR
2
QOR1_ECOLI
B:
[2-325]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
-
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
----
L
Y
P
P
-
P
S
L
----
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
-----
K
H
-
I
K
A
G
D
----------
R
V
V
---
Y
A
Q
--------------------------
S
A
-------
L
G
A
Y
S
S
V
H
N
I
-
I
A
-
D
K
A
A
I
L
P
A
A
I
S
-
F
E
---
Q
-
A
--
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
-
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
--
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
A
V
T
-
G
V
N
L
--
G
I
L
N
Q
K
G
S
-
L
Y
V
T
R
-
P
S
L
------
Q
G
Y
I
--
T
T
R
---------
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
--
V
AE
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
-
A
T
Q
G
S
S
L
L
I
P
-
32
HHSearch
87.85
36%
-102
- C1 -
1WLY
-
CAA43_BURSP
A:
[2-331]
-
V
M
A
A
V
I
H
K
K
G
G
P
D
-
N
F
V
W
E
E
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
------------
P
----
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
------
T
D
F
T
V
G
E
----------
R
V
C
---
T
C
L
--------------------------
P
P
-------
L
G
A
Y
S
Q
E
R
L
Y
-
P
A
-
E
K
L
I
K
V
P
K
D
L
D
-
L
D
---
D
-
V
H
L
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
-
T
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
--
D
F
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
I
G
K
D
T
L
Q
K
S
L
D
C
--
L
R
P
R
G
M
C
A
A
Y
G
H
A
S
G
-
V
A
D
P
I
R
------
V
V
E
-
D
-
L
G
V
R
G
-
S
L
F
I
T
RPA
L
W
H
Y
M
--
S
N
R
---------
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
S
S
--
V
--
A
K
T
F
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
R
-
Q
T
I
G
S
I
V
L
L
P
Q
23
PsiBlast_CBE
85.21
34%
-99
- C1 -
4RVU
1
?
B:
[7-326]
---
A
I
E
V
T
E
T
G
G
P
G
-
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
-----
Q
Y
P
-
R
E
L
----
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
--
D
T
A
I
S
V
G
D
----------
R
V
V
---
S
A
S
--------------------------
A
N
--------
G
A
Y
A
E
F
C
T
A
-
P
A
-
S
L
T
A
K
V
P
D
D
V
T
-
S
E
---
V
-
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
-
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
--
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
--
Q
R
L
N
A
A
G
S
-
V
Y
L
T
R
-
P
S
L
------
F
H
F
T
--
R
T
G
---------
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
T
V
G
S
V
V
L
L
P
-
7
PsiBlast_PDB
84.94
30%
-105
- C1 -
3QWA
-
QOR_YEAST
A:
[12-332]
----
I
L
I
D
E
I
G
G
Y
D
-
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
----
I
Y
P
C
-
E
K
-----
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
-----
T
N
-
F
E
V
G
D
----------
Q
V
A
---
Y
I
S
--------------------------
N
S
-------
T
F
A
Q
Y
S
K
-
I
S
-
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
-
D
E
E
L
K
L
-
Y
--
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
-
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
--
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
L
I
P
-
P
F
S
I
--
T
R
L
S
P
K
-
N
-
I
T
L
V
R
-
P
Q
L
------
Y
G
Y
I
--
A
D
P
---------
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
-
K
T
V
G
K
L
V
L
E
I
P
8
PsiBlast_PDB
84.04
30%
-101
- C1 -
3QWB
3
QOR_YEAST
A:
[12-332]
----
I
L
I
D
E
I
G
G
Y
D
-
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
----
I
Y
P
C
-
E
K
-----
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
-----
T
N
-
F
E
V
G
D
----------
Q
V
A
---
Y
I
S
--------------------------
N
S
-------
T
F
A
Q
Y
S
K
-
I
S
-
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
-
D
E
E
L
K
L
-
Y
--
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
-
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
--
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
L
I
P
-
P
F
S
I
--
T
R
L
S
P
K
-
N
-
I
T
L
V
R
-
P
Q
L
------
Y
G
Y
I
--
A
D
P
---------
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
-
K
T
V
G
K
L
V
L
E
I
P
28
HHSearch
83.46
29%
-104
- C1 -
3QWB
3
QOR_YEAST
A:
[8-332]
Q
Q
K
V
I
L
I
D
E
I
G
G
Y
D
-
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
----
I
Y
P
C
--
E
K
----
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
------
T
N
F
E
V
G
D
----------
Q
V
A
---
Y
I
S
-----------------------------------
N
S
T
F
A
Q
Y
S
K
I
-
S
S
Q
G
P
V
M
K
L
P
K
G
T
S
-
D
E
---
E
-
L
--
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
-
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
--
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
-
L
I
P
P
F
S
I
--
T
R
L
S
P
K
-
N
-
I
T
L
V
R
-
P
Q
L
------
Y
G
Y
I
--
A
D
P
---------
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
-
K
T
V
G
K
L
V
L
E
I
P
34
HHSearch
77.52
23%
-99
- C1 -
3GMS
-
?
A:
[2-330]
H
G
K
L
I
Q
F
H
K
F
G
N
P
K
D
V
L
Q
V
E
Y
K
N
I
E
P
L
K
D
N
E
V
F
V
R
M
L
V
R
P
I
N
P
S
D
L
I
P
I
T
G
----
A
Y
A
H
R
I
P
L
----
P
N
I
P
G
Y
E
G
V
G
I
V
E
N
V
G
A
F
V
------
S
R
E
L
I
G
K
----------
R
V
L
---
P
L
R
---------------------------
G
-------
E
G
T
W
Q
E
Y
V
K
T
-
S
A
-
D
F
V
V
P
I
P
D
S
I
D
-
D
F
---
T
-
A
--
A
Q
M
Y
---
I
N
P
L
T
A
W
V
T
C
T
E
T
L
N
L
Q
R
N
D
V
L
L
V
N
A
C
G
S
A
I
G
H
L
F
A
Q
L
S
Q
I
L
N
F
-
R
L
I
A
V
T
R
N
N
K
H
T
E
E
L
L
R
L
G
A
A
Y
V
I
D
T
S
T
A
--
P
L
Y
E
T
V
M
E
L
T
N
G
I
G
A
D
A
A
I
D
S
I
G
G
P
D
G
N
E
L
A
F
S
--
L
R
P
N
G
H
F
L
T
I
G
L
L
S
G
-
I
Q
--
V
N
W
--
A
E
I
V
T
K
-
A
-
K
V
H
A
N
I
F
H
L
------
R
H
W
N
D
E
V
S
P
---------
Y
K
W
Q
E
T
F
R
H
L
I
R
L
V
E
N
E
Q
L
R
F
M
K-
V
--
H
S
T
Y
E
L
A
D
V
K
A
A
V
D
V
V
Q
S
A
E
K
T
K
G
K
V
F
L
T
S
Y
31
HHSearch
75.24
27%
-97
- C1 -
2EIH
1
?
A:
[1-342]
-
M
R
A
V
V
M
R
A
R
G
G
P
E
-
V
L
E
V
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
----
V
A
S
P
K
L
P
L
----
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
------
E
G
F
A
P
G
D
----------
E
V
V
---
I
N
P
GLSCGRC
E
R
C
L
A
GEDNLCPRYQILGE
H
R
-------
H
G
T
Y
A
E
Y
V
V
L
-
P
E
-
A
N
L
A
P
K
P
K
N
L
S
-
F
E
---
E
-
A
--
A
A
I
P
---
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
-
R
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
P
--
D
W
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
Y
F
E
G
V
I
K
A
--
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
-
Y
E
G
T
L
P
F
--
A
H
V
F
Y
R
-
Q
-
L
S
I
L
G
-
S
T
M
------
A
-------------------
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
P
V
--
V
--
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
V
F
G
K
V
V
L
Q
V
G
19
PsiBlast_PDB
74.38
28%
-81
- C1 -
2EER
3
ADH_SULTO
A:
[3-345]
---
A
M
R
L
V
E
I
G
K
P
L
-
K
L
E
--
D
I
P
I
P
K
P
K
G
S
Q
V
L
I
K
I
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
RFGN
L
R
I
V
-
E
D
L
GVKL
P
V
T
L
G
H
E
I
A
G
R
I
E
E
V
G
D
E
V
VGYSK
G
D
L
V
A
V
N
P
WEGEGNC
Y
Y
C
R
I
G
EEH
L
C
D
--------------------------
S
P
RWLGINY
D
G
A
Y
A
E
Y
V
L
V
P
H
Y
-
K
Y
L
Y
K
L
-
R
R
L
S
-
A
V
---
E
-
A
--
A
P
L
T
---
C
S
G
V
T
T
Y
R
A
V
R
K
A
-
S
L
D
P
S
K
T
L
V
V
I
G
A
G
G
G
L
G
T
M
A
I
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
L
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
S
Q
--
D
P
V
S
E
I
R
R
I
T
Q
G
K
G
A
D
A
V
I
D
-
L
N
N
S
E
K
T
L
S
I
Y
P
YV
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
-
D
L
-
K
Y
H
A
--
P
L
I
T
L
N
-
E
-
V
Q
F
I
G
--
S
L
------
V
G
N
Q
--
S
D
F
---------
L
G
I
----
M
S
L
A
E
A
G
K
V
K
P
M
-----
V
--
T
K
T
M
K
L
E
E
A
N
E
A
I
D
N
L
E
N
F
-
K
A
V
G
R
Q
V
L
V
--
10
PsiBlast_PDB
73.30
27%
-91
- C1 -
2OBY
1
QORX_HUMAN
A:
[9-327]
---
A
V
H
F
D
K
P
G
G
P
E
-
N
L
Y
V
K
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
Q---
Y
D
P
P
-
P
G
A
----
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
-----
Q
G
H
W
K
I
G
D
-----------
T
A
---
M
A
L
--------------------------
L
P
-------
G
G
G
Q
A
Q
Y
V
T
V
-
P
E
-
G
L
L
M
P
I
P
E
G
L
T
-
L
T
---
Q
-
A
--
A
A
I
P
---
E
A
W
L
T
A
F
Q
L
L
H
L
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
-
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
--
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
--
G
-
D
I
N
G
--
P
L
F
-
S
K
-
L
-
L
F
K
R
G
-
S
L
I
------
T
S
L
L
--
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T
E
G
P
Q
R
L
L
P
V
--
L
--
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
-
K
N
I
G
K
I
V
L
E
L
P