@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0753: (2015-12-04 )
MLSNLWKKGTDFLGSEFAIMGGAMSWVSERNLVSAISNAGGFGVIACGAMSSDLLEKEIIETQKLTNKPFGVNLITMHPNLSELIDVCIETKVSHIVLAGGLPVKPNIEKIKNVGIEVMCFAPSLSLAKRLVKMGVDALIIEGMEAGGHIGPVSTSVLSQEILPYFKDERVPVFVAGGIGRGEMIVNYLEMGASGCQIGTLFVCTNESIAHKNFKEVFIKSAARDAISSVQISADFPVIPVRAIANKASDDFMQYQKEIIDKYHKGQISKEDGQLEIEKFWAGALRGAVIEGDIETGSLMAGQSVGMVDKEKPVKEVIDILIQQASNYIESKSVKVGDLIISKASS
Atome Classification :
(20 SA)
.........10........20......------..30........40....-....-50.........60....-....70...---------------.----.---..-----------------.----80----...--------------------------------------......90........100....------------------------------...---..110.-.--.....-120........130.......140.......150-------.......160.......-170-----------------.........180.......190.......200.......210.......-220....-...230.......240.......250.......260.......270.....-..280..-.....290.........300.......310.......320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
S
N
L
W
K
K
G
T
D
FLGS
E
F
A
I
MG
G
A
M
S
W
V
------
S
E
R
N
L
V
S
A
I
SNAGG
F
G
V
I
-
A
CGA-M-
S
S
D
L
L
E
K
E
I
I
E
T
Q
K
L-TNKPF
G
V
N
L
---------------
I
----
T
---MH-----------------P----
N
-----
L
S
E
--------------------------------------
L
I
D
V
C
I
ETKV
S
H
I
V
L
AG--GLPV------------------------------KP
N
---
I
E
K
I
K
N-V--G
I
E
V
M
-
C
F-AP
S
L
S
L
A
K
R
L
V
K
MG
V
D
A
L
I
I
E
G
M
EAGGHIGP-------
V
S
T
S
V
L
S
Q
E
I
L
P
Y
F
KDE-R-------------------
V
P
V
F
V
AGGIG
R
G
E
M
I
V
N
Y
L
E
MGASG
C
Q
I
G
T
L
F
V
CTNE
S
I
A
H
K
N
F
K
E
V
F
I
-
K
S
A
A
R
D
A
-
I
S
S
V
Q
I
SADFPVI
P
V
R
A
I
ANKA
S
D
D
F
M
Q
Y
Q
K
E
I
I
D
K
Y
HKGQISKEDGQ
L
E
I
-
E
K
F
W
A
G
A
-LRG
A
V
I
--EGDIETG
S
L
MAGQSVGMVDKEK
P
V
K
E
V
I
D
I
L
I
Q
Q
A
S
N
Y
I
ESKS
V
K
V
G
D
L
I
I
SKASS
1
PsiBlast_PDB
93.01
38%
-116
* C2 *
2Z6J
5
?
A:
[6-316]
---------
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
------
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
-
T
D
K
P
F
G
V
N
I
---------------
M
----
L
---
L
S
-----------------
P
----
F
-----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
--
G
N
P
S
------------------------------
K
-
Y
---
M
E
R
F
H
E
-
A
--
G
I
I
V
I
-
P
V
-
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
-----------------------
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
-
K
--
A
R
D
I
-
D
T
T
--
I
S
A
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
--------
A
F
----------
E
Q
M
G
A
G
A
-
L
A
K
A
V
V
--
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
-------
21
PsiBlast_CBE
91.98
38%
-114
- C2 -
2Z6J
4
?
B:
[6-316]
---------
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
------
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
-
T
D
K
P
F
G
V
N
I
---------------
M
----
L
---
L
S
-----------------
P
----
F
-----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
--
G
N
P
S
------------------------------
K
-
Y
---
M
E
R
F
H
E
-
A
--
G
I
I
V
I
-
P
V
-
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
-----------------------
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
-
K
--
A
R
D
I
-
D
T
T
--
I
S
A
Q
----
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
--------
A
F
----------
E
Q
M
G
A
G
A
-
L
A
K
A
V
V
--
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
V
------
57
HHSearch
91.41
37%
-101
- C2 -
2Z6I
5
?
A:
[1-319]
----
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
------
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
-
T
D
K
P
F
G
V
N
I
---------------
M
----
L
---
L
S
-----------------
P
----
F
-----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
--
G
N
P
-------------------------------
S
K
Y
---
M
E
R
F
H
E
-
A
--
G
I
I
V
I
-
P
V
-
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
-----------------------
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
-
K
A
R
D
I
D
T
-
T
I
S
----
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
-
F
K
Q
---------
D
L
E
I
F
-
E
Q
M
G
A
G
A
-
L
A
K
A
V
V
--
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
-------
58
HHSearch
91.16
37%
-109
- C2 -
3BO9
13
?
A:
[14-325]
---
T
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
------
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
-
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
-
T
D
K
P
F
G
V
N
I
---------------
I
----
L
---
V
S
-----------------
P
----
W
-----
A
D
D
--------------------------------------
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
--
G
N
P
-------------------------------
T
K
Y
---
I
R
E
L
K
E
-
N
--
G
T
K
V
I
-
P
V
-
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
-------
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
-----------------------
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
-
K
A
S
I
R
D
T
-
V
V
T
----
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
E
N
--------
P
------
M
Q
A
-
E
E
M
L
V
G
S
-
L
R
R
A
V
V
--
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
E
---------
3
PsiBlast_PDB
90.95
37%
-110
- C2 -
2Z6I
5
?
A:
[6-316]
---------
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
------
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
-
T
D
K
P
F
G
V
N
I
---------------
M
----
L
---
L
S
-----------------
P
----
F
-----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
--
G
N
P
S
------------------------------
K
-
Y
---
M
E
R
F
H
E
-
A
--
G
I
I
V
I
-
P
V
-
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
-----------------------
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
-
K
--
A
R
D
I
-
D
T
T
--
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
--------
A
F
K
Q
---
D
L
E
I
F
E
Q
M
G
A
G
A
-
L
A
K
A
V
V
--
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
-------
4
PsiBlast_PDB
88.95
32%
-113
- C2 -
4IQL
7
?
A:
[26-319]
----------
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
------
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
-
G
A
G
S
-
M
-
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
-
T
D
K
P
F
G
V
N
V
---------------
P
----
L
---
L
Y
-----------------
P
----
E
-----
M
D
K
--------------------------------------
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
--
G
S
P
-------------------------------
K
V
W
---
T
A
K
L
K
A
-
A
--
G
S
K
V
I
-
H
V
-
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
-------
E
E
T
T
T
L
C
--
L
I
P
E
V
V
D
A
V
N
-------------------
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
-
R
S
V
E
G
D
T
-
M
L
S
L
K
-----
A
V
S
P
T
R
L
L
K
N
K
-------
F
Y
Q
D
V
F
A
A
E
Q
R
G
A
S
V
E
E
L
R
E
L
-----
L
G
R
G
R
-
A
K
Q
G
I
F
--
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
E
I
----------
22
PsiBlast_CBE
87.67
32%
-112
- C2 -
4IQL
6
?
B:
[26-319]
----------
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
------
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
-
G
A
G
S
-
M
-
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
-
T
D
K
P
F
G
V
N
V
---------------
P
----
L
---
L
Y
-----------------
P
----
E
-----
M
D
K
--------------------------------------
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
--
G
S
P
-------------------------------
K
V
W
---
T
A
K
L
K
A
-
A
--
G
S
K
V
I
-
H
V
-
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
-------
E
E
T
T
T
L
C
--
L
I
P
E
V
V
D
A
V
N
-------------------
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
-
R
S
V
E
G
D
T
-
M
L
S
L
K
-----
A
V
S
P
T
R
L
L
K
N
K
-------
F
Y
Q
D
V
F
A
A
E
Q
R
G
A
S
V
E
E
L
R
E
L
-----
L
G
R
G
R
-
A
K
Q
G
I
F
--
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
E
I
----------
2
PsiBlast_PDB
86.99
35%
-107
- C2 -
3BO9
13
?
A:
[20-318]
---------
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
------
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
-
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
-
T
D
K
P
F
G
V
N
I
---------------
I
----
L
---
V
S
-----------------
P
----
W
-----
A
D
D
--------------------------------------
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
--
G
N
P
T
------------------------------
K
-
Y
---
I
R
E
L
K
E
-
N
--
G
T
K
V
I
-
P
V
-
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
-------
V
T
T
F
V
L
V
N
K
V
---
S
R
S
V
-
N
-------------------
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
-
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
-----
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
E
--------------
N
P
M
Q
A
-
E
E
M
L
V
G
S
-
L
R
R
A
V
V
--
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
E
---------
5
PsiBlast_PDB
85.84
28%
-104
- C2 -
2GJL
1
2NPD_PSEAE
A:
[9-320]
---------
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
------
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
-
T
D
R
P
F
G
V
N
L
--------------------
T
---
L
L
-----------------
P
----
T
QKPVP
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
--
N
D
P
G
------------------------------
E
-
H
---
I
A
E
F
R
R
-
H
--
G
V
K
V
I
-
H
K
-
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
--
P
-------
G
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
-------------------
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
-----
V
-
K
A
A
I
R
----
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
---
E
V
L
A
I
E
A
R
G
G
A
----
G
Y
A
D
I
-
A
A
L
V
S
G
Q
--
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
--------
6
PsiBlast_PDB
85.75
28%
-102
- C2 -
2GJN
2
2NPD_PSEAE
A:
[9-320]
---------
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
------
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
-
T
D
R
P
F
G
V
N
L
--------------------
T
---
L
L
-----------------
P
----
T
QKPVP
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
--
N
D
P
G
------------------------------
E
-
H
---
I
A
E
F
R
R
-
H
--
G
V
K
V
I
-
H
K
-
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
--
P
-------
G
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
-------------------
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
-----
V
-
K
A
A
I
R
----
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
---
E
V
L
A
I
E
A
R
G
G
A
----
G
Y
A
D
I
-
A
A
L
V
S
G
Q
--
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
--------
59
HHSearch
84.58
27%
-106
- C2 -
2GJL
1
2NPD_PSEAE
A:
[3-320]
---
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
------
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
-
S
A
L
T
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
-
T
D
R
P
F
G
V
N
L
---------------
T
----
L
---
L
P
-----------------
T
QKPV
P
-----
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
--
N
D
P
-------------------------------
G
E
H
---
I
A
E
F
R
R
-
H
--
G
V
K
V
I
-
H
K
-
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
DD-----
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
-----------------------
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
-
A
A
D
E
R
S
T
-
D
L
I
----
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
G
A
G
Y
-----------
A
D
I
-
A
A
L
V
S
G
Q
R
G
R
Q
V
Y
Q
--
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
--------
80
Fugue
83.31
25%
-98
- C2 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
V
F
R
T
---
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
------
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
-
S
A
L
T
-
Q
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
-
T
D
R
P
F
G
V
N
L
---------------
T
L
L
PT
Q
---
K
P
-----------------
V
----
P
-----
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
--
N
D
P
-------------------------------
G
E
H
---
I
A
E
F
R
R
-
H
--
G
V
K
V
I
-
H
K
-
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
-------
D
D
I
P
--
G
L
V
L
L
P
A
A
A
N
R
L
R
-------------------
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
-
A
A
D
E
R
S
-----
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
----------
G
G
A
G
Y
A
D
I
A
-
A
L
V
S
G
Q
R
-
G
R
Q
V
Y
Q
--
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
--------
9
PsiBlast_PDB
74.70
27%
-126
- C2 -
4QIT
2
?
A:
[12-275]
---------
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
------
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
-
T
D
K
P
F
N
V
N
L
---------------
F
----
C
---
H
R
-----------------
P
----
G
-----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
--
G
A
P
P
------------------------------
R
D
Q
---
V
R
A
L
Q
A
-
V
--
G
I
R
V
L
-
V
C
-
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
--------------------
V
F
E
P
E
-
R
GDAAIG
T
L
A
L
V
R
L
L
A
A
R
GS
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
-
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
-
H
D
F
A
A
Q
W
-
A
G
Q
G
A
A
--
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
-------------------------------------
7
PsiBlast_PDB
73.79
27%
-124
- C2 -
4Q4K
1
?
A:
[6-269]
---------
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
------
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
-
T
D
K
P
F
N
V
N
L
---------------
F
----
C
---
H
R
-----------------
P
----
G
-----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
--
G
A
P
P
------------------------------
R
D
Q
---
V
R
A
L
Q
A
-
V
--
G
I
R
V
L
-
V
C
-
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
--------------------
V
F
E
P
E
-
R
GDAAIG
T
L
A
L
V
R
L
L
A
A
RGS
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
-
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
-
H
D
F
A
A
Q
W
-
A
G
Q
G
A
A
--
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
------------------------------------
10
PsiBlast_PDB
73.51
27%
-126
- C2 -
4QIU
2
?
A:
[11-274]
---------
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
------
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
-
T
D
K
P
F
N
V
N
L
---------------
F
----
C
---
H
R
-----------------
P
----
G
-----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
--
G
A
P
P
------------------------------
R
D
Q
---
V
R
A
L
Q
A
-
V
--
G
I
R
V
L
-
V
C
-
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
--------------------
V
F
E
P
E
-
R
GDAAIG
T
L
A
L
V
R
L
L
A
A
RGS
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
-
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
-
H
D
F
A
A
Q
W
-
A
G
Q
G
A
A
--
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
------------------------------------
8
PsiBlast_PDB
73.36
27%
-129
- C2 -
4QIS
1
?
A:
[11-274]
---------
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
------
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
-
T
D
K
P
F
N
V
N
L
---------------
F
----
C
---
H
R
-----------------
P
----
G
-----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
--
G
A
P
P
------------------------------
R
D
Q
---
V
R
A
L
Q
A
-
V
--
G
I
R
V
L
-
V
C
-
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
--------------------
V
F
E
P
E
-
R
GDAAIG
T
L
A
L
V
R
L
L
A
A
RGS
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
-
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
-
H
D
F
A
A
Q
W
-
A
G
Q
G
A
A
--
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
--------------------------------------
74
HHSearch
62.41
15%
-142
- C2 -
3SGZ
2
HAOX2_RAT
A:
[67-321]
-------------
E
I
S
A
P
I
C
I
S
P
T
A
F
H
SIAWPD
G
E
K
S
T
A
R
A
A
Q
E
A
N
I
C
Y
V
I
-
S
S
Y
A
-
S
-
Y
--
S
L
E
-
D
I
V
A
A
--
A
-
P
E
G
F
R
W
F
Q
L
---------------
Y
----
M
---
K
S
-----------------
D
W
D
--
F
-----
N
K
Q
--------------------------------------
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
--
D
T
P
V
LGNR
R
R
D
K
R
N
Q
L
N
L
E
A
N
I
L
K
A
ALFPKASFC
W
N
D
---
L
S
L
L
Q
S
I
T
--
R
L
P
I
I
-
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
-------
S
A
S
I
D
A
L
R
E
V
V
A
A
V
K
-
G
-
K
-------------------
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
-
I
L
T
A
E
L
H
-
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
D
L
I
Q
F
S
R
-----------------------------------------------------------------------------------------------------
62
HHSearch
61.24
22%
-123
- C2 -
1EEP
1
IMDH_BORBU
A:
[30-303]
---
S
L
K
T
Q
L
T
K
N
I
S
L
N
I
P
F
L
S
S
A
M
D
T
V
------
T
E
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
-
H
K
N
M
---
S
I
E
A
Q
R
K
E
I
E
K
V
K
T
Y
K---------DFPN
A
C
K
D
LNN
K
L
R
V
G
----
A
A
V
S
I
D
-----------------
I
----
D
-----
T
I
E
--------------------------------------
R
V
E
E
L
V
K
A
H
V
D
I
L
V
I
D
S
AH
G
H
S
T
R
I
----------------------------
I
E
L
---
I
K
K
I
K
T
-
K
YP
N
L
D
L
I
A
G
N
-
I
V
T
K
E
A
A
L
D
L
I
S
V
G
A
D
C
L
K
V
-
G
I
G
P
G
S
I
C
T
T
R
I
V
AG
V
G
V
P
Q
I
T
A
I
C
D
V
Y
E
A
C
N
N
T
-
N
-------------------
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
A
G
A
D
S
V
M
I
G
N
L
F
A
G
T
K
E
S
P
S
E
E
I
I
Y
N
G
K
K
-
F
K
S
M
V
P
Y
-
S
G
K
L
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
A
T
I
S
D
L
K
I
N
S
K
F
V
K
I
S
H
S
----------------------------------------------------------------------------------
63
HHSearch
58.88
22%
-125
- C2 -
3FFS
-
IMDH_CRYPV
A:
[30-293]
---
S
L
E
T
K
L
T
K
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
------
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
-
H
K
N
M
-
D
-
M
E
S
Q
V
-
N
E
V
L
K
V
K
N
W
I-----------------------------
A
---
Y
S
N
E
N
L
D
NKG
R
L
R
V
G
A
A
I
G
V
----
N
------
I
E
--------------------------------------
R
A
K
L
L
V
E
A
G
V
D
V
I
V
L
D
S
--
A
H
G
H
S-----------------------------
L
N
I
I
R
T
L
K
E
I
K
S
K
M
--
N
I
D
V
I
-
V
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
-
G
I
--------IVAGVG-
V
P
Q
I
T
A
I
E
K
C
S
S
V
A
S
K
F
-
G
-------------------
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
I
G
D
T
V
-
Y
K
Y
R
V
K
Y
-
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
S
S
Y
V
E
I
T
T
S
----------------------------------------------------------------------------------
89
Fugue
57.98
18%
-108
- C2 -
4QCC
-
DGOA_ECOLI
A:
[5-274]
--
T
K
L
---------
P
L
I
A
I
L
R
G
I
T
P
D
E
------
A
L
A
H
V
G
A
V
I
D
A
--
G
F
D
A
V
-
E
I
P
--
L
-
N
S
P
Q
W
E
Q
S
I
P
A
I
V
D
A
-
Y
G
D
K
A
L
I
G
A
---------------
G
----
T
---
V
L
-----------------
K
-----------
P
E
--------------------------------------
Q
V
D
A
L
A
R
M
G
C
-
Q
L
I
V
T
P
--
N
I
H
-------------------------------
S
E
V
---
I
R
R
A
V
G
-
Y
--
G
M
T
V
C
-
P
G
-
C
A
T
A
T
E
A
F
T
A
L
E
A
G
A
Q
A
L
K
I
F
---
P
S
S
A
F
G
P
-------
Q
Y
I
K
A
L
K
A
-
V
L
P
----
S
-
D
-------------------
I
A
V
F
A
V
G
G
V
T
P
-
E
N
L
A
Q
W
I
D
A
G
C
A
G
A
G
L
G
S
D
L
Y
R
A
G
Q
S
------------------------------------------
V
E
R
T
A
Q
Q
A
A
A
F
V
K
A
Y
R
E
A
Q
K
Q
K
E
Q
R
Q
D
Q
K
-
S
A
Y
A
L
G
A
-
S
L
G
R
Y
M
--
E
N
S
L
K
E
Q
E
K
L
G
I
K
----
L
D
K
D
Q
L
I
A
G
V
Q
D
A
F
A
D
K
S
K
L
-----
S
D
Q
E
I
E
Q
T
L
Q
A
F
E
A