@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0068: (2016-03-11 )
MSIVLFLIVFILLSLIVSRYLYSVALNVPSKIDVVFNPIEKLIYQLIGTKLEHMSGKTYIKHFLLFNGLMGGLSFVLLLIQQWLFLNPNHNLNQSVSLAFNTMASFLTNTNLQHYAGETDLSYLTQMCVITFLMFTSAASGYAVCIAMLRRLTGMTDVIGNFYQDITRFIVRVLIPFALIISLFLISQGTPQTLKGNLVIETLSGVKQTIAYGPMASLESIKHLGTNGGGFLGANSSTPFENPTYWSNYAEALSMMLIPGSLVFLFGRMLKTKLQIHPHAIMIFVAMFVMFIGFLVTCLYFEFAGNPVLHHLGIAGGNMEGKETRFGIGLSALFTTITTAFTTGTVNNMHDSLTPLGGMVPMVLMMLNAVFGGEGVGLMNMLIYVMLTVFICSLMIGKTPSYLGMKIEGKEMKLIALSFLVHPLLILVFSALAFIVPGASDALTNPQFHGVSQVLYEFTSSSANNGSGFEGLGDNTVFWNISTGIVMLLARYIPIVLQILIVSSLVNKKTYQQHTQDVPINNLFFSSVLIIFIILLSGLTFLPDLMLGPIGEQLLLHA
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10---........20--......-..30-----......---..40--........---------.50........60...--.....70-........80.....-------...90---........100-........110.--.------.....120-....---.--------...130..-.....140-------.........-150---.....------..160.....-..170..----.....180-------.....---....190.......-------200.-.----.....210..-.....220.......230.......240.......250----........--260.....-..270.---..--....280........290.-......300.....-..--.---------310......-.320.....--.--.330.......340.......350....----...360....-....370.-..-....380.....----------..390..-..----..-------.400...-....410.......420.......430..-.-.-..--.440.......450.....-..460.......470.----......480.......------.490.-...--------...500.......-510...-....520.......530.....---..540..-------..-..-..550......----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
I
V
L
F
L
I
V
F
I
---
L
L
S
L
I
V
S
R
Y
L
--
Y
S
V
ALN-VPSK-----
I
D
V
V
F
N
---
P
I
E
---
K
L
I
Y
Q
L
I
G
---------
T
K
L
E
HMS
G
K
T
Y
I
K
H
F
L
--
L
F
N
G
L
M
G
-
G
L
S
F
V
L
L
L
I
Q
Q
W
L
F
L-------NPNHN---LN
Q
S
V
S
L
A
F
N
--
T
M
A
S
F
L
TNTN
L
Q
--H------YAGE
T
D
L
--
S
Y
L
T
---
Q
--------
M
C
V
I
T
F
L
M
-
F
TSAAS---------
G
Y
A
V
C
I
A
M
L
-
R
R
L---TG
M
T
D
------
V
I
G
N
F
Y
Q
D
I
T
-
R
F
I
V
R
V
L
----
I
P
F
A
L
I
---------
I
S
L
F
L
---ISQGTPQTLKG
N
L
V
-------
I
E
T
L
-
S
----
G
V
K
Q
T
I
AYGP-
M
A
S
L
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H
LGTNGGGFLGANSSTPFEN
P
T
Y
W
S
N
Y
A
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-----
A
L
S
M
M
LIP--
G
S
L
V
F
L
F
G
-
R
M
L
K
T
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---LQ--IH
P
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A
-
I
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M
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M
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-EFAGN-
P
V
--
L
---------
H
HLGIAGGN-MEGKE
T
R
FG--
I
--
G
L
S
A
L
F
T
T
I
T
T
A
F
TTGTVNNMHDSLTPL----
G
G
M
V
-
P
M
V
L
M
-
M
L
N
A
VFGG-E
G
-
V
G
L
M
N
M
L
I
Y
V
M
L
----------
T
V
F
I
C
S
L
-
M
I----GK-------TPSY
L
G
M
-
K
IEGK
E
M
K
L
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A
L
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F
L
V
H
P
L
L
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L
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F
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A
L
A
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-I-V-PG--ASDALTNPQFH
G
V
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L
Y
E
-
F
TSSSANNGSGFEGLG----D
N
T
V
F
W
N-I
S
T
G
I
V
M
L
------
L
A
R
Y
I
-
P
I
V
--------
L
Q
I
L
I
V
S
S
L
VN
K
K
-
T
Y
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Q
HT-QDVPI
N
N
L
F
F
S
S
V
L
I
I
F
I
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L
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---
G
L
T
F
-
L
P
-------
D
L
-
M
L-GP
I
G
E
Q
L
LLHA----------------------
14
Fugue
88.42
19%
-106
* C8 *
4J0D
6
?
A:
[22-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
S
N
R
L
I
--
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A
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W
L
-
V
P
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Q
-----
V
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A
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Q
---
A
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---
Y
Y
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-------------------
N
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-------
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---
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---
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----
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Y
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---------
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---------------------------------
A
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----
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-----
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---------
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----
G
---------------
M
G
S
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Q
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L
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T
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D
I
----
H
K
----------
Y
A
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F
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V
V
T
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D
L
D
L
S
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L
K
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F
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D
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--
L
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N
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K
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T
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T
A
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A
----
D
-------------
A
E
------
L
I
Q
A
I
-
N
P
L
--------
S
Y
L
T
T
T
S
S
Q
V
A
K
H
-
W
R
I
R
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G
---
A
A
D
R
D
T
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F
A
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A
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G
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G
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WDIPHSG
D
Y
-
D
L
-
G
D
L
F
S
W
I
D
G
L
C
Q---------------------
18
Fugue
84.06
18%
-98
- C3 -
4OO2
1
?
A:
[18-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRPLT
G
E
E
Y
L
E
S
L
R
D
A
R
E
V
Y
L
DGS
R
V
K
D
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--
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N
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A
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---
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---
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L
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P
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--
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A
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A
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K
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S
P
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Y
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---
A
S
F
L
G
T
L
G
A
N
AD
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A
R
R
W
--
Y
------
R
E
S
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K
V
--
L
Y
W
N
---
H
--------
A
----
F
L
H
-
P
P
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D
R
S
---------
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F
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V
-
E
R
E
---
T
D
A
G
L
------
V
V
S
G
A
K
V
V
A
T
-
G
------------
S
A
L
T
---------
H
A
A
F
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---
S
H
W
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L
P
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D
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K
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A
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-------
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D
A
-------------
D
G
L
K
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A
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P
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L
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ND
A
I
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V
L
D
Q
V
L
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--
W
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N
V
F
V
Y
G
-
N
L
G
K
V
H
---
L
L
--
A
G
Q
S
G
M
I
-----
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A
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F
H
G
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C
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R
L
A
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L
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F
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L
L
--
A
---------
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A
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D
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D
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Q
T
R
L
G
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--
A
W
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S
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D
A
A
A
R
N
P
V
P
W
K
N
G
T
L
L
P
N
----
P
Q
A
G
M
A
Y
R
W
F
M
Q
-----------
I
G
Y
P
R
V
L
E
I
V
Q
Q
----------
D
V
-
A
S
G
L
M
Y
V
----
N
S
-------
S
T
E
D
F
R
N
-
P
E
T
G
P
Y
L
E
K
Y
L
R
G
S
D
G
A
G
------
A
V
E
R
V
-
K
-
V
M
K
L
--
L
W
D
A
V
G
S
--
D
F
G
G
R
H
E
L
Y
E
-
R
N
Y
S
G
N
H
E
N
T
R
I
E
L
L
L
----
S
Q
T
A
-----------------------------------------
S
G
K
L
D
S
Y
M
D
F
A
Q
A
C
M
D
E
Y
D
L
D
G
W
T
A
P
D
------------------
L
E
-------
S
F
-
H
A
M
R
S
A
S
R
D
L
L
G
G
L
----------------------
15
Fugue
72.61
15%
-118
- C8 -
3J5P
-
TRPV1_RAT
A:
[1-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYD
R
R
S
I
F
D
A
V
A
Q
S
N
C
Q
E
L
E
S
L
L
---
P
F
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Q
R
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K
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--
T
D
S
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K
-
D
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GKT
C
L
L
K
A
M
L
N
---
L
H
N
GQN
D
T
I
A
L
L
L
D
---------
V
A
R
K
T
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S
L
K
Q
F
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N
A
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Y
--
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V
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---
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A
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G
D
F
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K
K
T
K
G
R
P
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F
G
E
L
P
L
--
S
L
A
A
C
T
N
Q
--------
L
A
I
V
K
F
L
L
-
Q
N
S
W
Q
P
ADISARDSV
G
N
T
V
L
H
A
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V
-
E
V
A
DNT
V
D
N
T
K
------
F
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M
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N
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I
L
-
I
L
G
A
K
L
H
----
P
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EITNRKGLT
P
L
A
L
A
---
A
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H
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PE
C
R
H
L
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----
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K
F
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M
L
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------
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N
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L
L
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---
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F
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I
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Y
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F
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M
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I
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F
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A
A
A
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--
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---------
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L
K
N
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G
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I
L
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S
G
G
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Y
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F
F
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Q
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S
V
D
S
Y
S
E
I
L
----
F
F
V
Q
-
S
L
F
M
L
-
V
S
V
V
L
Y
F
S
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R
-
K
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Y
V
A
S
M
V
F
S
L
A
----------
M
G
W
T
N
M
L
-
Y
Y
----
T
R
-------
G
F
Q
Q
M
G
I
Y
A
V
M
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K
M
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L
R
D
L
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M
F
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Y
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L
F
G
F
S
T
A
-
V
-
V
-
T
L
--
I
E
D
G
K
Y
N
S
-
L
Y
S
T
C
L
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L
F
K
-
F
T
I
G
M
G
D
L
------------
E
F
T
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N
Y
D
-
F
K
A
V
F
I
I
L
------
L
L
A
Y
V
-
I
L
T
--------
Y
I
L
L
L
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M
L
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I
-
A
Q
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I
W
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L
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R
A
I
T
I
L
D
T
E
K
S
---
F
L
K
C
-
M
R
-------
K
A
-------------------------------------
12
Fugue
72.48
17%
-125
- C9 -
4EPQ
1
?
A:
[34-472]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Q
F
P
L
P
Q
K
N
S
---
E
L
W
I
I
Q
K
K
T
L
--
Q
D
L
S
S
G
--
K
Q
K
-----
L
D
S
-
F
Q
---
S
L
E
---
S
I
L
E
I
L
R
D
---------
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K
N
Q
N
------
D
E
K
Y
F
--
N
L
K
A
V
F
E
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Q
L
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----
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Y
F
L
-------
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---
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I
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Q
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I
K
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K
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Q
I
P
K
--
E
------
S
K
I
Y
E
A
A
--
F
S
R
E
---
E
--------
I
S
Y
Y
V
S
C
M
-
F
-----------------
L
C
I
------------
L
K
D
------
Q
D
R
K
I
Y
K
D
F
R
-
L
I
Y
L
K
D
L
----
V
--------------------------
Q
Q
I
N
I
R
R
Q
E
K
-------
I
K
C
F
Y
E
----
Y
L
K
Q
A
L
D
F
S
E
-
K
E
S
K
E
V
V
I
F
Q
R
I
N
C
G
------------
Q
L
E
D
Y
E
N
W
V
D
-----
K
L
K
A
I
K
L
K
--
N
--
V
Q
L
T
D
-
D
K
L
------
I
E
--
D
F
P
G
T
-
L
Q
V
D
F
A
N
--
C
D
I
G
-
G
-------------------------------
G
I
L
G
N
G
-
L
V
Q
E
E
I
R
F
C
--
V
--
C
P
E
M
L
V
S
L
L
V
----------
F
D
Q
S
M
E
A
----------
N
E
V
I
I
-
M
K
-----------
G
I
K
Q
Y
S
D
Y
Q
G
Y
----------
S
N
S
F
R
F
V
-
K
M
----
G
N
-------
S
-------
K
I
Q
K
Q
K
R
T
--------
N
P
Q
T
I
L
A
I
D
A
L
C
F
-
N
-
S
-
S
D
NQ
F
S
E
V
N
V
S
R
E
L
N
-
K
S
Y
M
G
F
K
-
Q
E
D
Q
L
K
T
I
S
T
G
K
W
G
C
G
----
A
F
L
G
V
F
D
-
L
K
F
A
I
Q
W
I
------
A
S
S
R
S
-
N
K
K
--------
M
I
I
C
T
F
Q
D
E
Q
T
T
K
-
Q
I
Q
Q
V
F
-
D
L
Y
K
Q
K
N
---
A
S
I
F
L
K
L
V
M
D
Y
P
---
N
S
K
Y
-
M
E
-------
D
Y
T
L
L
-
E
Y
L
I
E
L
G
K
E
K
A
----------------------
2
HHSearch
69.38
14%
-102
- C10 -
3PJZ
1
TRKH_VIBPA
A:
[61-484]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
L
K
S
R
D
G
F
----------
L
I
V
-
V
L
F
W
T
V
L
G
S
A
G
S
L
P
F
-------
L
I
A
D
N
---
P
N
I
S
V
T
D
A
F
F
--
E
S
F
S
A
L
T
T
T
G
A
T
--
V
------
I
V
G
L
D
E
L
--
P
K
A
I
---
L
F
Y
R
Q
F
L
Q
W
F
G
G
M
G
I
I
V
-
L
A
---
V
---------
A
I
--
L
P
V
L
G
I
G
G
----------------
M
T
P
R
I
A
E
T
A
-
K
A
L
W
Y
I
Y
----
L
S
L
T
I
A
---------
C
A
V
A
F
---
W
L
A
G
------------------------------
M
T
P
F
D
----
A
I
S
H
S
F
S
T
I
A
I
G
G
F
S
T
H
D
-
A
S
M
-
G
Y
F
D
-
S
Y
A
I
N
L
I
T
-----
V
V
F
L
L
I
S
A
--
C
N
F
T
L
H
F
A
-
A
F
A
S
G
G
VHP
K
Y
YW
K
D
P
E
F
-
R
A
F
I
F
I
Q
V
L
L
F
L
V
-
C
F
--
L
L
L
L
-
K
H
H
S
------------------------
Y
-
T
S
P
Y
D
-
A
-------
F
D
Q
A
L
F
Q
T
V
S
I
S
T
T
A
G
F
T
T
T
G
F
A
D
W
P
L
F
----
L
P
V
L
-
L
L
F
S
S
-
F
I
G
G
C
A
G
S
-
T
G
-
G
G
M
K
V
I
R
I
L
L
L
T
-----------
L
Q
G
A
R
E
-
L
K
----
R
L
V
HPR
A
V
Y
T
I
K
V
G
G
S
-
A
L
P
Q
R
V
V
D
A
V
W
G
F
F
S
A
Y
A
L
V
F
V
V
C
M
-
L
G
L
-
I
-
A
-------------
T
G
M
D
E
L
S
A
F
S
A
-
V
A
A
T
L
N
N
L
G
P
G
L
G
E
V
A
LHFG
D
V
N
D
K
A
K
-
W
V
L
I
V
S
M
L
------
F
G
R
L
E
-
I
F
T
--------
L
L
I
L
L
T
P
T
F
W
R
----------------------------------------------------------------------------------------
19
Fugue
63.70
15%
-119
- C4 -
4XMM
-
NUP85_YEAST
D:
[18-715]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
P
M
T
V
N
D
Q
---
P
I
E
K
N
G
D
K
M
P
--
L
K
F
K
L
G
-
P
L
S
Y
-----
Q
N
M
A
F
I
---
T
A
K
---
D
K
-
Y
K
L
Y
P
---------
V
R
I
P
R
L
D
T
S
K
E
F
S
A
Y
V
S
G
L
F
E
I
Y
R
D
L
G
D
D
R
V
F
N
V
V
N
S
N
F
A
K
-------
E
H
N
A
T
---
V
N
L
A
M
E
A
I
L
N
--
E
L
E
V
F
I
G
R
V
K
D
Q
--
D
GRV
N
R
F
Y
E
L
E
E
S
L
--
T
V
L
N
---
C
--------
L
R
T
M
Y
F
I
L
D
G
Q
D
V
E
E
---------
N
R
S
E
F
I
E
S
L
-
L
N
W
---
I
N
R
S
D
GEPD
E
E
Y
I
E
Q
V
F
S
V
A
G
-
K
K
V
F
E
T
Q
----
Y
F
W
K
L
L
---------
N
Q
L
V
L
R
GL
L
S
Q
A
I
G
C
I
E
R
S
D
L
--------
L
P
Y
L
-
S
----
D
T
C
A
V
S
F
D
A
V
-
S
D
S
I
E
L
L
K
Q
Y
P
K
D
S
S
S
T
F
R
E
W
K
N
L
V
L
K
L
S
Q
A
F
G
S
S
A
T
-----
D
I
S
G
E
L
R
D
Y
I
E
D
F
L
L
V
I
G
-
G
N
Q
R
K
I
---
L
Q
--
Y
S
R
T
W
-
Y
E
S
F
C
G
F
L
L
Y
Y
I
P
S
L
E
L
S
A
E
Y
L
-
Q
M
S
L
E
-
A
N
--
V
VDITNDW
E
Q
P
C
V
D
I
I
S
G
K
-
I
H
S
I
L
P
V
M
E
--
S
L
D
S
C
T
A
A
F
T
A
M
I
C
E
A
K
-
G
L
I
E
N
I
F
E
G
L
E
D
L
FSYR
N
G
M
A
-
S
Y
M
L
N
-
S
F
A
F
E
L
C
S
-
L
G
D
K
E
L
W
P
V
A
I
G
L
I
A
L
SATGT
R
S
A
K
K
M
V
I
A
E
L
-
L
P
HYPF
V
T
-------
N
D
D
I
E
W
M
-
L
S
I
C
V
E
W
R
L
P
E
I
A
K
E
I
Y
T
T
L
G
N
I
E
S
I
A
N
F
S
L
-
V
-
K
S
--
Y
S
W
L
L
F
E
A
S
C
M
E
G
Q
K
V
L
N
A
-
I
V
S
K
D
-
D
V
I
I
P
Q
D
I
L
V
----
T
N
S
M
R
Q
T
-
L
A
P
Y
A
V
L
S
------
Q
F
Y
D
R
-
E
D
W
--------
G
Q
A
L
R
L
L
L
L
L
I
E
F
-
H
Y
L
V
L
L
-
V
A
K
F
L
Y
P
I
F
E
D
S
V
A
T
V
I
E
V
I
E
T
---
K
W
S
N
-
L
Y
-------
E
T
-
I
I
-
E
A
D
K
S
A
T
L
L
K
N
L
R
K
K
L
N
F
K
L
C
Q
A
F
M--------
21
Fugue
62.49
14%
-125
- C5 -
4ZUZ
-
?
A:
[7-863]
D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGDE
I
G
L
D
N
TC
Q
T
A
V
E
L
I
T
F
F
YGSAHSGVTKYS
A
E
H
Q
L
S
E
Y
K
R
Q
L
E
E
D
I
K
A
I
N
S
Q
KKISPHAY
D
D
L
L
K
E
K
I
E
R
L
Q
Q
I
E
K
Y
I
E
L
I
Q
V
L
K
K
QYDEQN
D
I
R
Q
L
R
TGGIPQLP
S
G
V
K
E
I
I
K
S
SEN
A
F
A
V
R
L
S
P
YDNDKFTRFDDPL
F
N
V
K
R
N
ISKYDTPSRQ
A
P
I
P
I
YEG
L
G
Y
R
L
R
S
T
L
FPEDK
T
P
T
P
I
N
K
K
S
L
R
D
K
V
K
S
T
V
L
S
HYKDEDRIDGEK
K
D
E
K
L
N
E
L
I
T
N
L
Q
N
E
L
V
K
E
L
V
K
S
DPQYSKLSLSKDPRG
K
E
I
N
YDYLVNSLMLVDNDSE
I
G
D
W
I
D
T
I
L
D
A
T
VDSTVWAVQASSPFYQGAKEISS
D
R
D
A
D
K
I
S
I
R
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
K
---
L
S
D
A
N
F
G
E
F
F
D
K
E
P
H
A
T
E
-
I
A
K
R
-----
V
K
E
G
F
T
Q
GA
D
I
E
---
P
I
I
Y
D
Y
I
N
S
NHAELGLK
S
P
L
T
G
K
Q
Q
Q
E
I
T
D
K
F
T
--
K
H
Y
N
T
I
K
-
E
S
P
H
F
D
----
E
F
F
V
A
-------
D
P
D
K
K
GN
I
F
S
H
Q
G
R
I
S
C
H
--
F
L
D
F
F
T
R
Q
T
K
G
K
--
H
------
P
L
G
D
L
A
---
S
H
Q
E
---
A
--------
L
Q
E
G
T
---------------------------
S
-
N
R
L
---
H
H
K
N
E
------
V
V
A
Q
G
Y
E
K
L
D
-
Q
F
K
K
E
V
V
----
K
L
L
A
---------------------
E
N
K
P
K
E
L
L
D
Y
L
V
-------
A
T
S
P
-
T
----
G
V
---
P
N
Y
S
M
-
L
-
S
K
E
T
Q
N
Y
I
A
Y
N
R
N
--
W
P
A
I
Q
K
E
L
E
K
A
T
S
I
P
E
S
Q
K
Q
-----
D
L
S
R
L
L
S
R
--
D
N
L
Q
H
--
D
-
N
L
S
A
I
T
---
W
S
--
K
Y
S
S
K
-
P
L
L
D
V
E
L
N
K
I
A
E
G
-
L
E
L
T
A
K
I
Y
-
N
E
K
R
G
-
R
E
--
W
---------
W
F
---
A
G
S
R
-
N
E
A
R
K
T
Q
C
E
--
E
---
L
Q
R
V
S
K
E
I
N
T
L
L
Q
S
E
S
L
T
--
K
S
Q
V
L
E
K
----
V
L
N
S
-
I
E
T
L
D
-
K
I
D
R
D
I
S
A
-
E
S
-
N
W
F
Q
S
---
T
L
Q
K
----------
E
V
R
L
F
R
D
-
Q
L
----
K
D
-------
I
C
Q
L
D
K
Y
-
Y
F
K
S
T
K
L
D
E
I
I
S
L
E
M
E
E
Q
F
Q
K
I
Q
D
P
A
V
Q
Q
-
I
-
V
-
R
D
--
L
P
S
H
C
H
N
------
D
E
A
I
E
F
-
F
K
T
-------------------------
L
N
P
E
E
A
A
K
------
V
A
S
Y
L
-
S
L
E
--------
Y
R
E
------
I
N
K
S
-
T
D
K
K
T
L
-
L
E
Q
D
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
---
E
-------------------
K
A
I
D
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T
13
Fugue
57.96
16%
-121
- C9 -
3GN6
6
?
A:
[22-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
P
W
T
D
-----
A
A
L
D
T
I
V
N
--
Q
A
L
T
L
Y
A
E
M
R
V
V
P
A
H
---
H
D
--
A
F
L
A
A
-
I
D
T
V
S
A
K
L
R
V
L
P
G
-
F
L
S
L
A
L
K
Q
M
S
G
D
S
T
M
V
K
--
N
---------
Y
P
E
T
Y
K
G
V
L
-
A
T
A
Y
L
D
G
V
A
--
A
--
G
T
Q
P
Y
F
Y
N
L
F
V
R
F
A
D
G
R
A
A
R
A
-----------
A
G
F
E
-
A
L
F
E
T
-
H
I
H
P
L
L
H
A
M
A
D
-
G
P
E
L
-----
L
A
Y
----------
R
A
V
L
Q
S
V
-
V
A
----
G
D
-------
R
H
A
I
Y
R
----
G
A
E
E
I
R
S
F
L
R
R
P
V
E
L
P
E
R
E
-
T
V
T
V
E
N
H
-
V
M
V
-
P
E
--
D
K
H
A
A
W
E
P
Q
V
A
I
L
L
Q
V
A
Q
D
T
F
E
P
Q
D
E
P
S
G
V
G
L
P
G
A
R
----
D
N
R
Y
Y
R
K
A
L
S
T
E
I
L
R
N
AHADGG
L
R
A
Y
I
M
H
G
V
W
ES
V
W
D
H
E
N
S
H
L
D
P
R
F
L
A
A
A
G
-
P
V
G
A
A
A
-
V
V
G
P
V
E
P
F
Y
L
T
R
R
L
V
V
A
D
------------------------------------------------------------
3
HHSearch
43.83
11%
-42
- C10 -
3PJZ
1
TRKH_VIBPA
A:
[204-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
P
F
D
A
I
S
--
H
S
F
S
T
I
A
I
G
G
F
S
--
T
------
H
D
A
S
M
G
Y
FD
S
Y
A
I
---
N
--------
L
I
-
T
V
V
F
L
-
L
I
-
S
A
C
---------
N
F
T
L
H
F
A
A
F
-
A
S
G
---
G
V
H
---------
P
K
Y
Y
W
K
D
P
E
F
R
A
F
I
F
I
Q
----
V
L
L
F
L
V
---------
C
F
L
L
L
----
L
K
H
-
H
S
Y
T
S
----------------------
P
Y
D
A
F
D
Q
----
A
L
F
Q
T
V
S
I
S
T
T
A
G
F
T
T
T
G
F
A
D
W
------
P
L
F
L
P
V
L
L
-----
L
F
S
S
F
I
G
G
--
C
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
42.04
20%
-46
* C10 *
1PU1
-
Y677_METTH
A:
[1-91]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
L
-
R
K
L
T
E
-
G
D
L
D
E
------
I
S
S
F
L
H
N
T
I
S
-
D
F
I
L
K
R
V
SAKE
I
V
D
I
D
I
---------
T
V
L
V
E
---
Y
T
D
E
L
K
V
D
I
S
A
E
L
Y
-------
L
D
E
L
-
S
D
A
D
P
G
I
V
D
E
A
V
D
A
A
-
Y
R
S
L
E
S
F
L
D
G
F
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
39.73
19%
-7
* C9 *
2KON
-
?
A:
[1-82]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
V
-
A
H
Y
---
R
G
Y
E
I
------
E
P
G
H
Q
Y
R
D
D
-----
I
R
K
Y
----
V
P
Y
A
L
I
---------
R
K
V
G
V
---
P
D
R
T
P
I
P
T
T
Y
P
E
F
Y
-------
D
L
E
A
-
D
----
A
E
R
V
S
I
A
----
C
A
K
I
I
I
D
S
H
L
D
R
H
D
Q
G
L
A
D
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
38.93
22%
-44
- C10 -
1LNQ
-
MTHK_METTH
A:
[19-101]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
-
T
R
I
L
L
L
V
L
A
V
I
I
Y
-
G
T
A
G
F
H
F
I
-
E
G
E
---------------------------------
S
-------
W
T
V
S
L
Y
W
T
F
V
T
I
A
T
V
G
Y
G
D
Y
--
S
P
S
T
P
L
----
G
M
Y
F
-
T
V
T
L
I
-
V
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
34.63
11%
88
- C10 -
3SPC
4
KCJ12_CHICK
A:
[93-155]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
F
V
A
A
F
L
F
-
S
I
E
T
Q
T
T
I
G
Y
G
F
R
C
V
T
----
E
E
C
P
L
A
V
-
F
M
V
V
V
Q
S
I
------
V
G
C
I
I
-
D
S
F
--------
M
I
G
A
I
M
A
K
M
A
R
P
K
-
K
R
-----------------------------------------------------------------------------------
9
HHSearch
30.69
10%
89
- C10 -
2QKS
5
KCNJ3_MOUSE
A:
[77-135]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
F
G
G
A
F
F
F
-
S
V
E
T
L
A
T
V
G
Y
--
G
D
M
H
----
P
Q
T
V
Y
A
H
-
W
I
A
T
L
E
I
F
------
V
G
M
S
S
-
I
A
L
--------
A
T
G
C
A
F
I
K
M
S
Q
P
K
--------------------------------------------------------------------------------------
7
HHSearch
30.56
12%
87
- C10 -
2Q67
3
?
A:
[48-104]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
P
I
D
A
L
Y
F
-
S
V
V
T
L
T
T
V
G
A
--
G
N
F
S
----
P
Q
T
D
F
G
K
-
I
F
T
I
L
Y
I
F
------
I
G
I
G
L
-
V
F
G
--------
F
I
H
K
L
A
V
N
V
Q
L
----------------------------------------------------------------------------------------
1
PsiBlast_PDB
29.93
36%
156
- C7 -
1G5G
1
FUS_NDVD
A:
[210-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
G
G
N
-
M
D
Y
L
L
T
K
L
G
--
V
--
G
N
N
Q
L
S
S
L
I
S
S
G
L
I
T
G
N
-
P
I
L
Y
D
S
Q
T
Q
L
----
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
26.68
27%
127
- C10 -
3UKM
5
KCNK1_HUMAN
A:
[94-140]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
S
A
L
F
F
A
S
T
V
L
S
T
T
G
Y
G
H
T
--
V
P
L
S
D
G
----
G
K
A
F
-
C
I
I
Y
S
-
V
I
G
I
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
21.09
33%
3108
- C2 -
2HWN
-
?
E:
[2-7]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
A
W
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
17.98
10%
2446
- C1 -
3EWT
-
E:
[8-14]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
M
T
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
16.95
35%
787
- C6 -
4RJF
-
?
B:
[3-22]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
Q
---
T
S
M
T
D
------
F
F
H
S
K
R
R
L
I
F
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------