@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0149: (2016-03-12 )
MNIVITGAKGFVGKNLKADLTSTTDHHIFEVHRQTKEEELESALLKADFIVHLAGVNRPEHDKEFSLGNVSYLDHVLDILTRNTKKPAILLSSSIQATQDNPYGESKLQGEQLLREYAEEYGNTVYIYRWPNLFGKWCKPNYNSVIATFCYKIARNEEIQVNDRNVELTLNYVDDIVAEIKRAIEGTPTIENGVPTVPNVFKVTLGEIVDLLYKFKQSRLDRTLPKLDNLFEKDLYSTYLSYLPSTDFSYPLLMNVDDRGSFTEFIKTPDRGQVSVNISKPGITKGNHWHHTKNEKFLVVSGKGVIRFRHVNDDEIIEYYVSGDKLEVVDIPVGYTHNIENLGDTDMVTIMWVNEMFDPNQPDTYFLEV
Atome Classification :
(20 SA)
.........10........20..-..-.------...30.....-------------------------.------------------------------------------.-------------------------.40.----..--.--....50........-----60------.........70........80........90........----------------------------100-----------------------------.........110.......120.......130.......140--------------.---.......150.-----.---.-----.--..--.160-........170.......180......-------.--190........200.-........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
V
I
TGAKGFVGKNLKADLTST-TD-
H
------
H
I
F
E
V
H
R
Q
T
K
-------------------------
E
------------------------------------------
E
-------------------------
E
L
E
S
----
A
L
--
L
--
K
A
D
F
I
V
H
L
AGVNRP-----E-------HDKEFSLG
N
V
S
Y
L
D
H
V
L
D
I
L
TRNTKK
P
A
I
L
L
SSSIQATQ----------------------------D-------------------------------NPYGESKL
Q
G
E
Q
L
L
R
E
Y
A
E
E
YG
N
T
V
Y
I
Y
RWPN
L
F
G
KWCKP
N
---------------
Y
---
N
S
V
I
A
T
F
C
Y
K
I-----A---R-----N--
E
E
--
I
Q
-V-NDR
N
V
E
L
T
L
N
Y
V
D
D
I
V
A
E
I
K
R
AIEGTP-------T--I-ENGVPTV
P
N
V
--
F
-
K
V
T
L
G
E
I
V
D
L
L
Y
K
F
K
Q
S
R
L
D
R
T
L
P
K
L
D
N
L
F
E
K
D
L
Y
S
T
Y
L
S
YLPSTDFSY
P
L
L
M
NVDDRG
S
F
T
E
F
IKTPDR
G
Q
V
S
V
NISKPGITKGNH
W
H
HTKN
E
K
F
L
V
V
SG
K
G
V
I
R
F
R
HV
N
D
D
E
I
I
E
Y
YVSGD
K
L
E
V
V
D
IPVGYTHNIENLGDT
D
M
V
T
I
M
W
V
N
E
MFDPNQP
D
T
Y
F
L
EV
2
PsiBlast_PDB
95.59
98%
-113
- C1 -
3ST7
3
?
A:
[2-369]
-
N
I
V
I
T
G
A
K
G
F
V
G
K
N
L
K
A
D
L
T
S
T
-
T
D
-
H
------
H
I
F
E
V
H
R
Q
T
K
-------------------------
E
------------------------------------------
E
-------------------------
E
L
E
S
----
A
L
--
L
--
K
A
D
F
I
V
H
L
A
G
V
N
R
P
-----
E
-------
H
D
K
E
F
S
L
G
N
V
S
Y
L
D
H
V
L
D
I
L
T
R
N
T
K
K
P
A
I
L
L
S
S
S
I
Q
A
T
Q
----------------------------
D
-------------------------------
N
P
Y
G
E
S
K
L
Q
G
E
Q
L
L
R
E
Y
A
E
E
Y
G
N
T
V
Y
I
Y
R
W
P
N
L
F
G
K
W
C
K
P
N
---------------
Y
---
N
S
V
I
A
T
F
C
Y
K
I
-----
A
---
R
-----
N
--
E
E
--
I
Q
-
V
-
N
D
R
N
V
E
L
T
L
N
Y
V
D
D
I
V
A
E
I
K
R
A
I
E
G
T
P
-------
T
--
I
-
E
N
G
V
P
T
V
P
N
V
--
F
-
K
V
T
L
G
E
I
V
D
L
L
Y
K
F
K
Q
S
R
L
D
R
T
L
P
K
L
D
N
L
F
E
K
D
L
Y
S
T
Y
L
S
Y
L
P
S
T
D
F
S
Y
P
L
L
M
N
V
D
D
R
G
S
F
T
E
F
I
K
T
P
D
R
G
Q
V
S
V
N
I
S
K
P
G
I
T
K
G
N
H
W
H
H
T
K
N
E
K
F
L
V
V
S
G
K
G
V
I
R
F
R
H
V
N
D
D
E
I
I
E
Y
Y
V
S
G
D
K
L
E
V
V
D
I
P
V
G
Y
T
H
N
I
E
N
L
G
D
T
D
M
V
T
I
M
W
V
N
E
M
F
D
P
N
Q
P
D
T
Y
F
L
E
V
37
Fugue
94.91
99%
-114
- C1 -
2ZKL
2
?
A:
[1-369]
M
N
I
V
I
T
G
A
K
G
F
V
G
K
N
L
K
A
D
L
T
S
T
-
T
D
-
H
------
H
I
F
E
V
H
R
Q
T
K
-------------------------
E
------------------------------------------
E
-------------------------
E
L
E
S
----
A
L
--
L
--
K
A
D
F
I
V
H
L
A
G
V
F
S
L
--------------------
G
N
V
S
Y
L
D
H
V
L
D
I
L
T
R
N
T
K
K
P
A
I
L
L
S
S
S
I
Q
A
T
Q
----------------------------
D
-------------------------------
N
P
Y
G
E
S
K
L
Q
G
E
Q
L
L
R
E
Y
A
E
E
Y
G
N
T
V
Y
I
Y
R
W
P
N
L
F
G
K
W
C
K
P
N
---------------
Y
---
N
S
V
I
A
T
F
C
Y
K
I
-----
A
---
R
-----
N
--
E
E
--
I
Q
-
V
-
N
D
R
N
V
E
L
T
L
N
Y
V
D
D
I
V
A
E
I
K
R
A
I
E
G
T
P
-------
T
--
I
-
E
N
G
V
P
T
V
P
N
V
--
F
-
K
V
T
L
G
E
I
V
D
L
L
Y
K
F
K
Q
S
R
L
D
R
T
L
P
K
L
D
N
L
F
E
K
D
L
Y
S
T
Y
L
S
Y
L
P
S
T
D
F
S
Y
P
L
L
M
N
V
D
D
R
G
S
F
T
E
F
I
K
T
P
D
R
G
Q
V
S
V
N
I
S
K
P
G
I
T
K
G
N
H
W
H
H
T
K
N
E
K
F
L
V
V
S
G
K
G
V
I
R
F
R
H
V
N
D
D
E
I
I
E
Y
Y
V
S
G
D
K
L
E
V
V
D
I
P
V
G
Y
T
H
N
I
E
N
L
G
D
T
D
M
V
T
I
M
W
V
N
E
M
F
D
P
N
Q
P
D
T
Y
F
L
E
V
1
PsiBlast_PDB
94.04
100%
-115
- C1 -
2ZKL
2
?
A:
[1-369]
M
N
I
V
I
T
G
A
K
G
F
V
G
K
N
L
K
A
D
L
T
S
T
-
T
D
-
H
------
H
I
F
E
V
H
R
Q
T
K
-------------------------
E
------------------------------------------
E
-------------------------
E
L
E
S
----
A
L
--
L
--
K
A
D
F
I
V
H
L
A
G
V
--------------------
F
S
L
G
N
V
S
Y
L
D
H
V
L
D
I
L
T
R
N
T
K
K
P
A
I
L
L
S
S
S
I
Q
A
T
Q
----------------------------
D
-------------------------------
N
P
Y
G
E
S
K
L
Q
G
E
Q
L
L
R
E
Y
A
E
E
Y
G
N
T
V
Y
I
Y
R
W
P
N
L
F
G
K
W
C
K
P
N
---------------
Y
---
N
S
V
I
A
T
F
C
Y
K
I
-----
A
---
R
-----
N
--
E
E
--
I
Q
-
V
-
N
D
R
N
V
E
L
T
L
N
Y
V
D
D
I
V
A
E
I
K
R
A
I
E
G
T
P
-------
T
--
I
-
E
N
G
V
P
T
V
P
N
V
--
F
-
K
V
T
L
G
E
I
V
D
L
L
Y
K
F
K
Q
S
R
L
D
R
T
L
P
K
L
D
N
L
F
E
K
D
L
Y
S
T
Y
L
S
Y
L
P
S
T
D
F
S
Y
P
L
L
M
N
V
D
D
R
G
S
F
T
E
F
I
K
T
P
D
R
G
Q
V
S
V
N
I
S
K
P
G
I
T
K
G
N
H
W
H
H
T
K
N
E
K
F
L
V
V
S
G
K
G
V
I
R
F
R
H
V
N
D
D
E
I
I
E
Y
Y
V
S
G
D
K
L
E
V
V
D
I
P
V
G
Y
T
H
N
I
E
N
L
G
D
T
D
M
V
T
I
M
W
V
N
E
M
F
D
P
N
Q
P
D
T
Y
F
L
E
V
3
PsiBlast_PDB
92.46
98%
-127
- C1 -
3VHR
3
?
A:
[2-369]
-
N
I
V
I
T
G
A
K
G
F
V
G
K
N
L
K
A
D
L
T
S
T
-
T
D
-
H
------
H
I
F
E
V
H
R
Q
T
K
-------------------------
E
------------------------------------------
E
-------------------------
E
L
E
S
----
A
L
--
L
--
K
A
D
F
I
V
H
L
A
-----------------------
S
L
G
N
V
S
Y
L
D
H
V
L
D
I
L
T
R
N
T
K
K
P
A
I
L
L
S
S
S
--------------------------------------------------------------------------
G
E
Q
L
L
R
E
Y
A
E
E
Y
G
N
T
V
Y
I
Y
R
W
P
N
L
F
G
K
W
C
K
P
N
---------------
Y
---
N
S
V
I
A
T
F
C
Y
K
I
-----
A
---
R
-----
N
--
E
E
--
I
Q
-
V
-
N
D
R
N
V
E
L
T
L
N
Y
V
D
D
I
V
A
E
I
K
R
A
I
E
G
T
P
-------
T
--
I
-
E
N
G
V
P
T
V
P
N
V
--
F
-
K
V
T
L
G
E
I
V
D
L
L
Y
K
F
K
Q
S
R
L
D
R
T
L
P
K
L
D
N
L
F
E
K
D
L
Y
S
T
Y
L
S
Y
L
P
S
T
D
F
S
Y
P
L
L
M
N
V
D
D
R
G
S
F
T
E
F
I
K
T
P
D
R
G
Q
V
S
V
N
I
S
K
P
G
I
T
K
G
N
H
W
H
H
T
K
N
E
K
F
L
V
V
S
G
K
G
V
I
R
F
R
H
V
N
D
D
E
I
I
E
Y
Y
V
S
G
D
K
L
E
V
V
D
I
P
V
G
Y
T
H
N
I
E
N
L
G
D
T
D
M
V
T
I
M
W
V
N
E
M
F
D
P
N
Q
P
D
T
Y
F
L
E
V
68
HHSearch
56.43
21%
-85
- C1 -
3EHE
1
?
A:
[3-264]
-
L
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
S
E
S
-
N
--
E
-------
I
V
V
I
D
N
L
S
S
-------------------------
G
NEEFVNEA
A
R
L
V
KADLAA------------------------
D
-------------------------
D
I
K
D
----
Y
L
--
K
--
G
A
E
E
V
W
H
I
A
A
N
P
D
V
RGA--
E
-------
N
P
D
E
I
Y
R
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
G
-
V
S
R
I
V
F
T
S
T
S
T
V
Y
G
EAKVIPTPED
Y
P
T
H
P
-------------
I
-------------------------------
S
L
Y
G
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
H
T
F
D
M
Q
A
W
I
Y
R
F
A
N
V
I
G
R
R
S
T
H
G
---------------------
V
I
Y
D
F
I
M
K
L
-----
K
---
R
N----
P
--
E
E
--
L
E
-
I
L
G
N
G
E
Q
N
K
S
Y
I
Y
I
S
D
C
V
D
A
M
L
F
G
L
R
G
D
E
-------
R
-----
V
N
I
F
N
I
G
S
E
--
D
-
Q
I
K
V
K
R
I
A
E
I
V
C
E
E
L
G
L
S
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
56.36
23%
-86
- C1 -
2B69
3
UXS1_HUMAN
A:
[28-285]
K
R
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
D
-
G
--
H
------
E
V
T
V
V
D
N
F
F
T
-------------------------
G
RKRNVEHWIGHEN
F
E
L
I
NH-----------------------
D
-------------------------
V
V
E
P
----
L
Y
--
I
--
E
V
D
Q
I
Y
H
L
A
S
P
A
S
P
-----
P
N
Y
M
Y
---
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
G
--
A
R
L
L
L
A
S
T
S
E
V
Y
G
DPEVHPQSEDYW
G
H
V
N
PIGP--------
R
-------------------------------
A
C
Y
D
E
G
K
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
E
G
V
E
V
R
V
A
R
I
F
N
T
F
G
P
R
M
H
M
N
---------------
D
---
G
R
V
V
S
N
F
I
L
Q
A
-----
L
---
Q
-----
G
--
E
P
--
L
T
-
V
Y
G
S
G
S
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
G
L
V
A
L
M
N
S
N
V
-------------
S
S
P
V
N
L
G
N
P
--
E
-
E
H
T
I
L
E
F
A
Q
L
I
K
N
L
V
G
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.20
21%
-99
- C1 -
1R6D
2
?
A:
[1-264]
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
-
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
Y
AGNRANLAPVDADPR
L
R
F
V
HGDIRD
A
------------------------------------------
G
-------------------------
L
L
A
R
----
E
L
--
R
--
G
V
D
A
I
V
H
F
A
A
E
S
H
V
-----
D
R
S
I
A
---
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
G
-
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
SID
S
G
S
W
T
ESSPLEP-------------
N
-------------------------------
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
E
--------------------
K
L
I
P
L
F
V
T
N
L
-----
L
---
D
-----
G
--
G
T
--
L
P
-
L
Y
G
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
G
R
-------
A
-----
G
E
I
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
56.08
16%
-85
- C1 -
1E6U
7
FCL_ECOLI
A:
[4-267]
Q
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
R
-
G
--
D
------
V
E
L
V
L
R
T
R
D
E
LNLLD--------------------
S
------------------------------------------
R
-------------------------
A
V
H
D
----
F
F
A
S
E
--
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
-----
I
V
A
N
N
T
--
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
KLAKQPMAESELLQGTLEPT--------
N
-------------------------------
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
PS-------------
N
---
S
H
V
I
P
A
L
L
R
R
F
-----
H
---
E
A
T
A
Q
K
A
--
P
D
--
V
V
V
W
-
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
L
A
H
E
V
W
L
E
N
T
Q
--
P
-
M
L
S
H
I
N
V
G
T
G
--
V
-
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
56.07
22%
-96
- C1 -
3SC6
3
?
A:
[6-235]
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
-
E
--
Y
------
D
I
Y
P
F
D
K
K
L
L
DITN---------------------
I
------------------------------------------
S
-------------------------
Q
V
Q
Q
----
V
V
--
Q
E
I
R
P
H
I
I
I
H
C
A
A
Y
T
K
V
-----
D
QAEK---
E
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
--
A
K
L
V
Y
I
S
T
D
Y
V
F
Q
GDRPEGYDEF
H
N
P
A
P
-------------
I
-------------------------------
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
----
H
N
K
Y
F
I
V
R
T
S
W
L
Y
G
K
Y
G
N
N
----------------------
F
V
K
T
M
I
R
L
G
-----
K
---
E
-----
R
--
E
E
--
I
S
-
V
--
V
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
N
K
L
I
H
T
S
L
-------------
Y
G
T
Y
H
V
S
N
T
--
G
-
S
C
S
W
F
E
F
A
K
K
I
F
S
Y
A
N
M
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
55.90
28%
-96
* C1 *
2PK3
2
RMD_ANETH
A:
[13-270]
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
-
N
--
V
------
E
V
F
G
T
S
R
N
N
E
-------------------------
A
K
L
P
NVE
M
I
S
L
DIMD
S
---------------------------
Q
-------------------------
R
V
K
K
----
V
I
--
S
D
I
K
P
D
Y
I
F
H
L
A
A
K
S
S
V
-----
K
D
S
W
L
---
N
K
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
N
L
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
MILPEESPVSEE
N
Q
L
R
P
-----------
M
-------------------------------
S
P
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
G
Q
S
L
G
--------------------
F
V
T
Q
D
F
A
K
Q
I
V
D
I
E
M
E
---
K
-----
Q
--
E
P
--
I
I
K
V
-
G
N
L
E
A
V
R
D
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
K
-------
T
-----
G
D
V
Y
N
V
C
S
G
--
I
-
G
T
R
I
Q
D
V
L
D
L
L
L
A
M
A
N
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
55.61
19%
-98
- C1 -
2HUN
1
?
A:
[4-264]
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
-
H
P
D
W
------
E
V
I
N
I
D
K
L
G
Y
GSNPANLKDLEDDPR
Y
T
F
V
K
G
D
VAD
Y
------------------------------------------
E
-------------------------
L
V
K
E
----
L
V
--
R
--
K
V
D
G
V
V
H
L
A
A
E
S
H
V
-----
D
R
S
I
S
---
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N
P
E
V
R
F
V
H
V
S
T
D
E
V
Y
G
DIL
K
G
S
F
T
EN
D
R
L
M
P
-------------
S
-------------------------------
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
P
Y
Q
F
P
E
--------------------
K
L
I
P
K
T
I
I
R
A
-----
S
---
L
-----
G
--
L
K
--
I
P
-
I
Y
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
G
E
-------
S
-----
R
E
I
Y
N
I
S
A
G
--
E
-
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
55.51
16%
-86
- C1 -
1OC2
4
?
A:
[5-274]
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
-
H
P
D
V
------
H
V
T
V
L
D
K
L
T
Y
AGNKANLEAILGD------------
R
V
E
L
V
V
G
D
IAD
A
-------------------------------
E
-------------------------
L
V
D
K
----
L
A
--
A
--
K
A
D
A
I
V
H
Y
A
A
E
S
H
N
-----
D
N
S
L
N
---
D
P
S
P
F
I
H
T
N
F
I
G
T
Y
T
L
L
E
A
A
R
K
Y
D
--
I
R
F
H
H
V
S
T
D
E
V
Y
G
DLPLREDLPGHGEGPGEKFTAET
N
Y
N
P
-
S
-------------------------------
S
P
Y
S
S
T
K
A
A
S
D
L
I
V
K
A
W
V
R
S
F
G
V
K
A
T
I
S
N
C
S
N
N
Y
G
P
Y
Q
H
I
E
--------------------
K
F
I
P
R
Q
I
T
N
I
-----
L
---
A
-----
G
--
I
K
--
P
K
-
L
Y
G
E
G
K
N
V
R
D
W
I
H
T
N
D
H
S
T
G
V
W
A
I
L
T
K
G
R
-------
M
-----
G
E
T
Y
L
I
G
A
D
--
G
-
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
54.56
19%
-98
- C1 -
2C5A
13
GME_ARATH
A:
[30-294]
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
E
-
G
--
H
------
Y
V
I
A
S
D
W
K
K
N
-------------------------
E
HMTEDMFCDEFHLVDLRV
M
-----------------------
E
-------------------------
N
C
L
K
----
V
T
--
E
--
G
V
D
H
V
F
N
L
A
A
D
M
G
G
MGFIQ
S
-------
N
H
S
V
I
M
Y
N
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
G
-
I
K
R
F
F
Y
A
S
S
A
C
I
Y
P
EFKQLETTNVSLKESDAWPAEP------
Q
-------------------------------
D
A
F
G
L
E
K
L
A
T
E
E
L
C
K
H
Y
N
K
D
F
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
P
F
G
T
W
K
---------------
G
GR-
E
K
A
P
A
A
F
C
R
K
A
-----
Q
---
T
-----
S
T-
D
R
--
F
E
-
M
W
G
D
G
L
Q
T
R
S
F
T
F
I
D
E
C
V
E
G
V
L
R
L
T
K
S
D
F
-------------
R
E
P
V
N
I
G
S
D
--
E
-
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
K
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
54.12
16%
-100
- C1 -
1VL0
2
?
A:
[13-241]
M
K
I
L
I
T
G
A
N
G
Q
L
G
R
E
I
Q
K
Q
L
K
G
K
-
N
--
V
------
E
V
I
P
T
D
V
Q
D
L
DITN---------------------
V
------------------------------------------
L
-------------------------
A
V
N
K
----
F
F
--
N
E
K
K
P
N
V
V
I
N
C
A
A
H
T
A
V
-----
D
K
C
E
E
---
Q
Y
D
L
A
Y
K
I
N
A
I
G
P
K
N
L
A
A
A
A
Y
S
V
G
-
A
-
E
I
V
Q
I
S
T
D
Y
V
F
D
GEAKEPITEF
D
E
V
N
P
-------------
Q
-------------------------------
S
A
Y
G
K
T
K
L
E
G
E
N
F
V
K
A
----
L
N
P
K
Y
Y
I
V
R
T
A
W
L
Y
G
D
G
N
N
-----------------------
F
V
K
T
M
I
N
L
G
-----
K
---
T
-----
H
--
D
E
--
L
K
-
V
--
V
H
D
Q
V
G
T
P
T
S
T
V
D
L
A
R
V
V
L
K
V
I
D
E
K
N
-------------
Y
G
T
F
H
C
T
C
K
--
G
-
I
C
S
W
Y
D
F
A
V
E
I
F
R
L
T
G
I
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
53.83
24%
-85
- C1 -
3KO8
2
?
A:
[1-265]
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
-
G
--
Y
------
E
V
V
V
V
D
N
L
S
S
-------------------------
G
------------------------------------------
R
REFVNPS
A
E
L
H
VR------------
D
L
K
D
YSWG
A
G
--
I
--
K
G
D
V
V
F
H
F
A
A
N
P
E
V
-----
R
LSTT---
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
G
-
V
R
T
V
V
F
A
S
S
S
T
V
Y
G
DADVIPTPEEEPYKP-------------
I
-------------------------------
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
F
G
V
R
C
L
A
V
R
Y
A
N
V
V
G
P
R
L
R
H
G
---------------------
V
I
Y
D
F
I
M
K
L
-----
R
---
R
-----
N
P-
N
V
--
L
E
V
L
-----
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
-----
D
--
A
-
P
F
L
A
L
N
V
G
N
V
--
D
-
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
L
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
53.63
16%
-105
- C1 -
2BLL
-
ARNA_ECOLI
A:
[316-600]
M
R
V
L
I
L
G
V
N
G
F
I
G
N
H
L
T
E
R
L
L
R
E
-
D
H
-
Y
------
E
V
Y
G
L
D
I
G
S
D
-------------------------
A
ISRFLNHPH
F
H
F
V
E
G
D
ISIHS---------------------
E
-------------------------
W
I
E
Y
----
H
V
--
K
--
K
C
D
V
V
L
P
L
V
A
I
A
T
P
-----
I
E
Y
T
R
---
N
P
L
R
V
F
E
L
D
F
E
E
N
L
R
I
I
R
Y
C
V
K
Y
--
R
K
R
I
I
F
P
S
T
S
E
V
Y
G
MCSDKYFDED
H
S
N
L
I
V
G
P
VNKP------
R
-------------------------------
W
I
Y
S
V
S
K
Q
L
L
D
R
V
I
W
A
Y
G
E
K
E
G
L
Q
F
T
L
F
R
P
F
N
W
M
G
P
R
L
D
N
L
NAARIG---------
S
---
S
R
A
I
T
Q
L
I
L
N
L
-----
V
---
E
-----
G
--
S
P
--
I
K
-
L
I
D
G
G
K
Q
K
R
C
F
T
D
I
R
D
G
I
E
A
L
Y
R
I
I
E
N
A
G
N------
R
--
C
-
D
G
E
I
I
N
I
G
N
P
--
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
E
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
52.59
20%
-84
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-290]
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
-
G
--
I
------
D
L
I
V
F
D
N
L
S
R
-------------------------
K
G
A
T
D
N
L
H
W
L
S
S
L
G
N
F
E
F
V
H
G
D
IRN
K
-----------------
N
-------------------------
D
V
T
R
----
L
I
--
T
K
Y
M
P
D
S
C
F
H
L
A
G
Q
V
A
M
-----
T
T
S
I
D
---
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
N
S
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
----------------------------
D
LEQ
Y
K
Y
N
E
T
ETRYTCVDKPNGYDEST
Q
L
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
G
R
Q
F
A
T
---------------
Y
D--
Q
G
W
V
G
W
F
C
Q
K
A
-----
V
E
I
K
N
-----
G
IN
K
P
--
F
T
-
I
S
G
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
S
-------
K
--
I
-
R
G
N
A
F
N
I
G
G
T
IV
N
-
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
52.35
21%
-80
- C1 -
2YY7
6
?
A:
[3-262]
P
K
I
L
I
I
G
A
C
G
Q
I
G
T
E
L
T
Q
K
L
R
K
L
Y
G
T
-
E
------
N
V
I
A
S
D
I
R
K
L
-------------------------
N
T
D
V
V
N
S
G
P
F
E
V
V
N
ALD
F
-------------------------
N
-------------------------
Q
I
E
H
----
L
V
E
V
H
--
K
I
T
D
I
Y
L
M
A
A
L
L
S
A
-----
T
A
E
K
----
N
P
A
F
A
W
D
L
N
M
N
S
L
F
H
V
L
N
L
A
K
A
K
K
-
I
K
K
I
F
W
P
S
S
I
A
V
F
G
PTTPKENTPQY
T
I
M
E
P
------------
S
-------------------------------
T
V
Y
G
I
S
K
Q
A
G
E
R
W
C
E
Y
Y
H
N
I
Y
G
V
D
V
R
S
I
R
Y
P
G
L
I
S
W
S
T
P
P
G
---------------
G
GTT
D
Y
A
V
D
I
F
Y
K
A
I
-----
A
---
D
-----
K
--
K
Y
--
E
C
-
F
-
L
S
S
E
T
K
M
P
M
M
Y
M
D
D
A
I
D
A
T
I
N
I
M
K
A
P
V
-------
E
KI
K
-
I
H
S
S
Y
N
L
A
A
M
----
S
F
T
P
T
E
I
A
N
E
I
K
K
H
I
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
52.09
15%
-83
- C1 -
1I24
4
SQD1_ARATH
A:
[12-324]
S
R
V
M
V
I
G
G
D
G
Y
C
G
W
A
T
A
L
H
L
S
K
K
-
N
--
Y
------
E
V
C
I
V
D
N
L
V
R
-------------------------
R
L
F
D
H
Q
L
GLESL
T
P
I
A
S
I
H
D
R
I
S
R
W
K
A
L
TG
K
S
I
E
L
Y
V
G
D
ICD
F
E
-------------------------
F
L
A
E
----
S
F
--
K
S
F
E
P
D
S
V
V
H
F
G
E
Q
R
S
A
-----
P
Y
S
M
ID
R
S
R
A
V
Y
T
Q
H
N
N
V
I
G
T
L
N
V
L
F
A
I
K
E
F
G
E
E
C
H
L
V
K
L
G
T
M
G
E
Y
G
TPNIDIEEG
Y
I
T
I
T
H
NG
R
T
D
T
L
P
Y
P
K
Q
A
S
-------------------------------
S
F
Y
H
L
S
K
V
H
D
S
H
N
I
A
F
T
C
K
A
W
G
I
R
A
T
D
L
N
Q
G
V
V
Y
G
V
K
T
D
E
T
EMHEEL
R
N
R
L
D
YDAV
F
---
G
T
A
L
N
R
F
C
V
Q
A
-----
A
---
V
-----
G
--
H
P
--
L
T
-
V
Y
G
K
G
G
Q
T
R
G
Y
L
D
I
R
D
T
V
Q
C
V
E
I
A
I
A
N
P
A
-------
K
--
A
G
E
F
R
V
F
N
Q
F
T
---
E
-
Q
F
S
V
N
E
L
A
S
L
V
T
K
A
G
S
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
50.69
13%
-86
- C1 -
1RPN
3
GM4D_PSEAE
A:
[15-279]
R
S
A
L
V
T
G
I
T
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
-
G
--
Y
------
R
V
H
G
L
V
A
R
R
S
-------------------------
S
------------------------------------------
D
TR
W
R
L
R
E
L
GIEGDIQ
Y
E
D
G
D
MAD
A
C
S
V
Q
R
----
A
V
--
I
K
A
Q
P
Q
E
V
Y
N
L
A
A
Q
S
F
V
-----
G
ASWN---
Q
P
V
T
T
G
V
V
D
G
L
G
V
T
H
L
L
E
A
I
R
Q
F
S
P
E
T
R
F
Y
Q
A
S
T
S
E
M
F
G
LIQAERQDENT
P
F
Y
P
-------------
R
-------------------------------
S
P
Y
G
V
A
K
L
Y
G
H
W
I
T
V
N
Y
R
E
S
F
G
L
H
A
S
S
G
I
L
F
N
H
E
S
P
L
R
G
I
E
F--------------
V
---
T
R
K
V
T
D
A
V
A
R
I
-----
K
---
L
-----
G
--
K
Q
Q
E
L
R
-
L
-
G
N
V
D
A
K
R
D
W
G
F
A
G
D
Y
V
E
A
M
W
L
M
L
Q
Q
D
K
-------------
A
D
D
Y
V
V
A
T
G
--
V
-
T
T
T
V
R
D
M
C
Q
I
A
F
E
H
V
G
L
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------