@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1052: (2016-03-21 )
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDHLRERLVGRGTESNEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
Atome Classification :
(39 SA)
.........10........20.......-.30.-.......40........50........60........70........80--..--......90........100.......110...--.-.--..120.......130.......140.......150.......---160.---..--......170.......180.......190.......200.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDNEK
G
L
L
I
V
LSGPSGVG
K
G
T
V
R
K
R
IFE-DPST-
S
Y
K
Y
S
I
S
M
T
T
R
Q
MREGEVDG
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
IKDD
Q
F
I
E
Y
A
E
Y
V
G
N
--YY--G
T
P
V
Q
Y
V
K
D
T
MDEG
H
D
V
F
L
E
I
E
VE
G
A
K
Q
V
R
K
K--F-P--
D
A
L
F
I
F
LAPP
S
L
D
H
L
R
E
R
L
VGRGTES
N
E
K
I
Q
S
R
I
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
VN
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
LEAKK
23
PsiBlast_CBE
91.82
99%
-102
- C2 -
4QRH
3
?
B:
[5-209]
-
D
N
E
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
L
E
H
L
-------------------
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
L
E
A
K
-
1
PsiBlast_PDB
91.62
99%
-109
- C2 -
4QRH
1
?
A:
[6-204]
--
N
E
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
L
E
H
L
-------------------
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
------
24
PsiBlast_CBE
90.78
99%
-108
- C2 -
2J41
4
KGUA_STAAC
D:
[5-206]
----
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
------------------------
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
L
E
A
K
-
21
PsiBlast_CBE
90.73
99%
-99
- C2 -
4QRH
6
?
D:
[6-203]
--
N
E
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
L
E
H
L
--------------
I
Q
S
R
I
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
-------
22
PsiBlast_CBE
90.59
99%
-100
- C2 -
4QRH
4
?
C:
[6-208]
--
N
E
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
L
E
H
L
------------------
I
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
L
E
A
--
26
PsiBlast_CBE
87.18
99%
-108
- C2 -
2J41
3
KGUA_STAAC
B:
[5-205]
----
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
----------------------------
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
L
E
A
--
25
PsiBlast_CBE
86.60
99%
-103
- C2 -
2J41
3
KGUA_STAAC
C:
[5-197]
----
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
-------------------
Q
S
R
I
N
E
A
R
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
----------
50
HHSearch
85.42
61%
-96
- C2 -
3TAU
3
KGUA_LISMO
A:
[5-204]
--
T
E
R
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
E
A
V
F
K
-
D
P
E
T
-
S
F
D
Y
S
I
S
M
T
T
R
L
P
R
E
G
E
Q
D
G
V
D
Y
Y
F
R
S
R
E
V
F
E
Q
A
I
K
D
G
K
M
L
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
L
E
Y
V
E
E
K
L
A
A
G
V
D
I
F
L
E
I
E
V
Q
G
A
M
Q
V
R
K
A
--
M
-
P
--
E
G
I
F
I
F
L
T
P
P
D
L
S
E
L
K
N
R
-------
S
M
E
V
V
E
E
R
M
E
T
A
K
K
E
I
E
---
M
--
M
---
A
S
--
Y
D
Y
A
V
V
N
D
V
V
A
N
A
V
Q
K
I
K
G
I
V
E
T
E
H
L
K
T
E
R
V
I
H
R
Y
K
K
M
L
-----
2
PsiBlast_PDB
85.35
99%
-110
- C2 -
2J41
1
KGUA_STAAC
A:
[4-197]
---
E
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
-
D
P
S
T
-
S
Y
K
Y
S
I
S
M
T
T
R
Q
M
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
K
--
F
-
P
--
D
A
L
F
I
F
L
A
P
P
S
---------------------------
K
E
V
E
---
M
--
M
---
N
L
--
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
----------
3
PsiBlast_PDB
85.20
60%
-96
- C2 -
3TAU
3
KGUA_LISMO
A:
[5-204]
--
T
E
R
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
E
A
V
F
K
-
D
P
E
T
-
S
F
D
Y
S
I
S
M
T
T
R
L
P
R
E
G
E
Q
D
G
V
D
Y
Y
F
R
S
R
E
V
F
E
Q
A
I
K
D
G
K
M
L
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
L
E
Y
V
E
E
K
L
A
A
G
V
D
I
F
L
E
I
E
V
Q
G
A
M
Q
V
R
K
A
--
M
-
P
--
E
G
I
F
I
F
L
T
P
P
D
L
S
E
L
K
N
R
-------
S
M
E
V
V
E
E
R
M
E
T
A
K
K
E
I
E
---
M
--
M
---
A
S
--
Y
D
Y
A
V
V
N
D
V
V
A
N
A
V
Q
K
I
K
G
I
V
E
T
E
H
L
K
T
E
R
V
I
H
R
Y
K
K
M
L
-----
12
PsiBlast_PDB
80.67
40%
-85
- C2 -
1S96
2
KGUA_ECOLI
A:
[15-213]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
27
PsiBlast_CBE
80.35
40%
-82
- C2 -
2F3T
1
KGUA_ECOLI
F:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
62
HHSearch
80.22
39%
-86
- C2 -
1S96
2
KGUA_ECOLI
A:
[15-214]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
-
T
Q
P
L
Y
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
----
8
PsiBlast_PDB
79.41
40%
-83
- C2 -
2F3T
1
KGUA_ECOLI
A:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
29
PsiBlast_CBE
79.38
40%
-85
- C2 -
2F3T
1
KGUA_ECOLI
B:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
---
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
28
PsiBlast_CBE
78.73
40%
-83
- C2 -
2F3T
1
KGUA_ECOLI
E:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
61
HHSearch
78.14
40%
-101
- C2 -
1ZNW
-
KGUA_MYCTU
A:
[20-201]
----
V
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
E
-
R
I
P
--
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
L
H
R
S
--
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
V
----------------------
6
PsiBlast_PDB
77.59
40%
-83
- C2 -
2ANC
-
KGUA_ECOLI
A:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
7
PsiBlast_PDB
76.85
40%
-81
- C2 -
2F3R
1
KGUA_ECOLI
A:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
----
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
16
PsiBlast_PDB
76.80
42%
-92
- C2 -
1ZNW
-
KGUA_MYCTU
A:
[21-192]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
4
PsiBlast_PDB
76.02
40%
-78
- C2 -
2AN9
3
KGUA_ECOLI
A:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
19
PsiBlast_PDB
75.85
42%
-86
- C2 -
1ZNZ
1
KGUA_MYCTU
A:
[20-191]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
18
PsiBlast_PDB
75.72
42%
-90
- C2 -
1ZNY
1
KGUA_MYCTU
A:
[20-191]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
31
PsiBlast_CBE
75.03
40%
-77
- C2 -
2AN9
3
KGUA_ECOLI
B:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
30
PsiBlast_CBE
74.98
40%
-85
- C2 -
2F3R
1
KGUA_ECOLI
B:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
----
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
17
PsiBlast_PDB
74.63
42%
-92
- C2 -
1ZNX
1
KGUA_MYCTU
A:
[20-191]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
20
PsiBlast_PDB
74.40
42%
-90
- C2 -
1Z8F
2
KGUA_MYCTU
A:
[23-194]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
C
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
C
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
15
PsiBlast_PDB
73.59
42%
-88
- C2 -
1S4Q
4
KGUA_MYCTU
A:
[23-194]
-----
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
-
V
R
C
L
R
-
E
R
I
P
-
N
L
H
F
S
V
S
A
T
T
R
A
P
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
T
--
M
-
P
--
E
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
---
G
D
--
F
D
K
V
V
V
N
R
R
L
E
S
A
-------------------------------
14
PsiBlast_PDB
73.51
39%
-81
- C2 -
3TR0
3
KGUA_COXBU
A:
[6-204]
----
K
A
N
L
F
I
I
S
A
P
S
G
A
G
K
T
S
L
V
R
A
L
V
K
--
A
L
A
-
E
I
K
I
S
I
S
H
T
T
R
P
K
R
P
G
D
Q
E
G
V
D
Y
F
F
I
D
E
T
R
F
Q
A
M
V
K
E
G
A
F
L
E
H
A
T
I
Y
E
R
--
H
Y
--
G
T
E
K
D
W
V
L
R
Q
L
K
A
G
R
D
V
L
L
E
I
D
W
Q
G
A
R
Q
I
R
E
L
--
F
-
P
--
P
A
L
S
I
F
I
L
P
P
S
I
E
A
L
R
E
R
L
I
K
R
R
Q
D
D
T
A
I
I
E
Q
R
L
A
L
A
R
E
E
M
A
---
H
--
Y
---
K
E
--
F
D
Y
L
V
V
N
D
N
F
D
Q
A
V
Q
N
L
I
H
I
I
S
A
E
R
L
Q
R
D
V
Q
E
K
K
L
S
R
L
L
A
E
---
11
PsiBlast_PDB
72.51
42%
-79
- C2 -
1GKY
3
KGUA_YEAST
A:
[4-185]
--------
I
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
A
-
E
Y
P
D
-
S
F
G
F
S
V
S
S
T
T
R
T
P
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
-
K
A
--
I
-
P
EL
N
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
---
Y
A
E
T
---
G
A
--
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
A
E
--------------------
5
PsiBlast_PDB
72.39
40%
-73
- C2 -
2ANB
2
KGUA_ECOLI
A:
[3-201]
----
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
K
T
Q
P
L
Y
-
D
T
Q
V
S
V
S
H
T
T
R
Q
P
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
K
--
M
-
P
--
H
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
---
A
E
--
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
-----
57
HHSearch
71.83
41%
-80
- C2 -
1EX7
3
KGUA_YEAST
A:
[1-183]
-----
S
R
P
I
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
A
-
E
Y
P
D
-
S
F
G
F
S
V
S
S
T
T
R
T
P
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
K
A
I
--
P
E
L
--
N
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
---
Y
A
E
T
---
G
A
--
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
----------------------
53
HHSearch
71.69
39%
-80
* C2 *
3TR0
3
KGUA_COXBU
A:
[5-200]
---
N
K
A
N
L
F
I
I
S
A
P
S
G
A
G
K
T
S
L
V
R
A
L
V
K
-
A
L
-
A
-
E
I
K
I
S
I
S
H
T
T
R
P
K
R
P
G
D
Q
E
G
V
D
Y
F
F
I
D
E
T
R
F
Q
A
M
V
K
E
G
A
F
L
E
H
A
T
I
Y
E
R
--
H
Y
--
G
T
E
K
D
W
V
L
R
Q
L
K
A
G
R
D
V
L
L
E
I
D
W
Q
G
A
R
Q
I
R
E
L
--
F
-
P
--
P
A
L
S
I
F
I
L
P
P
S
I
E
A
L
R
E
R
L
I
K
R
R
Q
D
D
T
A
I
I
E
Q
R
L
A
L
A
R
E
E
M
A
---
H
--
Y
---
K
E
--
F
D
Y
L
V
V
N
D
N
F
D
Q
A
V
Q
N
L
I
H
I
I
S
A
E
R
L
Q
R
D
V
Q
E
K
K
L
S
R
-------
10
PsiBlast_PDB
71.67
42%
-82
- C2 -
1EX7
3
KGUA_YEAST
A:
[4-185]
--------
I
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
A
-
E
Y
P
D
-
S
F
G
F
S
V
S
S
T
T
R
T
P
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
-
K
A
--
I
-
P
EL
N
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
---
Y
A
E
T
---
G
A
--
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
A
E
--------------------
55
HHSearch
68.35
37%
-68
- C2 -
1LVG
3
KGUA_MOUSE
A:
[5-192]
------
R
P
V
V
L
S
G
P
S
G
A
G
K
S
T
L
L
K
K
L
F
Q
-
E
H
S
S
-
I
F
G
F
S
V
S
H
T
T
R
N
P
R
P
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
M
Q
R
D
I
A
A
G
D
F
I
E
H
A
E
F
S
G
N
--
L
Y
--
G
T
S
K
E
A
V
R
A
V
Q
A
M
N
R
I
C
V
L
D
V
D
L
Q
G
V
R
S
I
K
K
T
--
D
-
L
--
C
P
I
Y
I
F
V
Q
P
P
S
L
D
V
L
E
Q
R
L
R
L
R
N
T
E
T
E
E
S
L
A
K
R
L
A
A
A
R
T
D
M
E
SSK
E
--
P
---
G
L
--
F
D
L
V
I
I
N
D
D
L
D
K
A
Y
A
T
L
K
Q
A
L
S
E
E
I
K
K
A
----------------
33
PsiBlast_CBE
67.53
39%
-67
- C2 -
1LVG
3
KGUA_MOUSE
A:
[7-177]
--------
V
V
L
S
G
P
S
G
A
G
K
S
T
L
L
K
K
L
F
Q
-
E
H
S
S
-
I
F
G
F
S
V
S
H
T
T
R
N
P
R
P
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
M
Q
R
D
I
A
A
G
D
F
I
E
H
A
E
F
S
G
N
--
L
Y
--
G
T
S
K
E
A
V
R
A
V
Q
A
M
N
R
I
C
V
L
D
V
D
L
Q
G
V
R
S
I
K
K
T
--
D
-
L
--
C
P
I
Y
I
F
V
Q
P
P
S
L
D
V
L
E
Q
R
L
R
L
R
N
T
E
T
E
E
S
L
A
K
R
L
A
A
A
R
T
D
M
E
---
S
--
S
KEP
G
L
--
F
D
L
V
I
I
N
D
D
L
D
K
A
-------------------------------
34
PsiBlast_CBE
65.11
36%
-78
- C2 -
1Z6G
6
?
A:
[26-202]
--------
L
V
I
C
G
P
S
G
V
G
K
G
T
L
I
K
K
L
L
N
-
E
F
P
N
-
Y
F
Y
F
S
V
S
C
T
T
R
K
K
R
E
K
E
K
E
G
V
D
Y
Y
F
I
D
K
T
I
F
E
D
K
L
K
N
E
D
F
L
E
Y
D
N
Y
A
N
N
--
F
Y
--
G
T
L
K
S
E
Y
D
K
A
K
E
Q
N
K
I
C
L
F
E
M
N
I
N
G
V
K
Q
L
K
K
S
TH
I
-
K
--
N
A
L
Y
I
F
I
K
P
P
S
T
D
V
L
L
S
R
L
L
T
R
N
T
E
N
Q
E
Q
I
Q
K
R
M
E
Q
L
N
I
E
L
H
---
E
--
A
---
N
L
L
N
F
N
L
S
I
I
N
D
D
L
T
L
T
Y
Q
Q
L
K
--------------------------
60
HHSearch
62.95
33%
-75
- C2 -
1Z6G
6
?
A:
[22-209]
----
N
I
Y
P
L
V
I
C
G
P
S
G
V
G
K
G
T
L
I
K
K
L
L
N
-
E
F
P
N
-
Y
F
Y
F
S
V
S
C
T
T
R
K
K
R
E
K
E
K
E
G
V
D
Y
Y
F
I
D
K
T
I
F
E
D
K
L
K
N
E
D
F
L
E
Y
D
N
Y
A
N
N
--
F
Y
--
G
T
L
K
S
E
Y
D
K
A
K
E
Q
N
K
I
C
L
F
E
M
N
I
N
G
V
K
Q
L
K
K
S
--
T
-
H
IK
N
A
L
Y
I
F
I
K
P
P
S
T
D
V
L
L
S
R
L
L
T
R
N
T
E
N
Q
E
Q
I
Q
K
R
M
E
Q
L
N
I
E
L
H
---
E
A
N
L
---
L
N
--
F
N
L
S
I
I
N
D
D
L
T
L
T
Y
Q
Q
L
K
N
Y
L
L
N
S
Y
-------------------
51
HHSearch
59.80
35%
-68
- C2 -
2QOR
2
?
A:
[9-198]
--
M
A
R
I
P
P
L
V
V
C
G
P
S
G
V
G
K
G
T
L
I
K
K
V
L
S
-
E
F
P
S
-
R
F
R
F
S
I
S
C
T
T
R
N
K
R
E
K
E
T
N
G
V
D
Y
Y
F
V
D
K
D
D
F
E
R
K
L
K
E
G
Q
F
L
E
F
D
K
Y
A
N
N
--
F
Y
--
G
T
L
K
S
E
Y
D
L
A
V
G
E
G
K
I
C
L
F
E
M
N
I
N
G
V
K
Q
L
K
E
S
--
K
-
H
IQ
D
G
I
Y
I
F
V
K
P
P
S
I
D
I
L
L
G
R
L
K
N
R
N
T
E
K
P
E
E
I
N
K
R
M
Q
E
L
T
R
E
M
D
E
A
-
D
--
K
---
V
G
--
F
N
Y
F
I
V
N
D
D
L
A
R
T
Y
A
E
L
R
E
Y
L
L
G
S
Y
-------------------