@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1211: (2016-03-23 )
MIELKHVTFGYNKKQMVLQDINITIPDGENVGILGESGCGKSTLASLVLGLFKPVKGEIYLSDNAVLTIFQHPLTSFNPDWTIETSLKEALYYYRGLTDNTAQDQLLLQHLSTFELNAQLLTKLPSEVSGGQLQRFNVMRSLLAQPRVLICDEITSNLDVIAEQNVINILKAQTITNLNHFIVISHDLSVLQRLVNRIIVLKDGMIVDDFAIEELFNVDRHPYTKELVQTFSY
Atome Classification :
(22 SA)
.........10..----......20.---.......30........40........50........60..--------------.---------------.--------------.-------------------------...70.....-----..--.80...---......90....--...-----.100....---...110..-----.....120..---------.-----------....130.......140.......150.......160....----...170.......180---.........190.......200.......210.......220.......230.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
E
L
K
H
V
TFGYN
K
----
K
Q
M
V
L
Q
DI
N
---
I
T
IPDGE
N
V
G
I
L
GESGC
G
K
S
T
L
A
S
L
V
L
G
L
FKPVK
G
E
I
Y
LSD--------------N---------------
A
--------------
V
-------------------------
L
T
IFQHPLTS-----FN--PD-
W
T
I
---
E
T
S
L
K
E
A
L
Y
Y
YR--GLT-----DN
T
A
Q
D
Q
L
---
L
L
Q
H
L
S
T
F
-----
E
L
N
A
Q
L
L
T
KL---------P-----------SEVSGG
Q
L
Q
R
F
N
V
M
R
S
L
LAQP
R
V
L
I
C
D
E
ITSN
L
D
V
I
A
E
Q
N
V
----
I
N
I
L
K
A
Q
T
ITNL
N
H
-----
F
I
V
I
SH
D
L
S
V
L
Q
R
L
V
N
R
I
I
V
LKD
G
M
I
V
D
D
F
A
I
E
E
L
FNVDRHP
Y
T
K
E
L
V
Q
TFSY
47
HHSearch
83.90
26%
-128
- C1 -
2OLJ
4
?
A:
[24-261]
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------------
I
---------------
N
--------------
L
KAKDTN
L
N
K
V
R
E
E
V
-----------
G
M
V
F
Q
R
F
N
-------
L
F
--
P
H
-
M
T
V
---
L
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
------
R
E
K
A
E
A
K
---
A
M
E
L
L
D
K
V
-----
G
L
K
-
D
K
A
H
A
Y
---------
P
-----------
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
----
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
---
35
HHSearch
80.88
26%
-126
- C1 -
3TUI
1
METN_ECOLI
C:
[24-264]
M
I
K
L
S
N
I
T
K
V
F
H
Q
GTR-
T
I
Q
A
L
N
N
V
S
---
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
--------------
Q
ELTTLSESELTKARR
Q
--------------
I
-------------------------
G
M
I
F
Q
H
F
N
-------
L
L
--
S
S
-
R
T
V
---
F
G
N
V
A
L
P
L
E
L
D
N
--
T
-------
P
K
D
E
V
K
R
R
---
V
T
E
L
L
S
L
V
-----
G
L
G
-
D
K
H
D
S
Y
---------
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
----
L
E
L
L
K
D
I
N
R
R
L
G
L
T
-----
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
-----
19
PsiBlast_PDB
80.69
29%
-119
- C1 -
4YMU
2
?
J:
[16-236]
--------------------
V
L
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKINNGKVNINKVR
Q
---------------
K
--------------
V
-------------------------
G
M
V
F
Q
H
---------
F
N
LF
P
H
-
L
T
A
---
I
E
N
I
T
L
A
P
V
K
V
K
--
K
M
N
-----
K
K
E
A
E
-------------------
E
L
A
V
D
L
L
A
K
V
GLLDKKDQY
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
----
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-----
18
PsiBlast_PDB
80.51
29%
-124
- C1 -
4YMT
-
?
J:
[16-236]
--------------------
V
L
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKINNGKVNINKVR
Q
---------------
K
--------------
V
-------------------------
G
M
V
F
Q
H
---------
F
N
LF
P
H
-
L
T
A
---
I
E
N
I
T
L
A
P
V
K
V
K
--
K
M
N
-----
K
K
E
A
E
-------------------
E
L
A
V
D
L
L
A
K
V
GLLDKKDQY
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
----
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-----
17
PsiBlast_PDB
80.37
29%
-123
- C1 -
4YMS
-
?
J:
[16-236]
--------------------
V
L
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKINNGKVNINKVR
Q
---------------
K
--------------
V
-------------------------
G
M
V
F
Q
H
---------
F
N
LF
P
H
-
L
T
A
---
I
E
N
I
T
L
A
P
V
K
V
K
--
K
M
N
-----
K
K
E
A
E
-------------------
E
L
A
V
D
L
L
A
K
V
GLLDKKDQY
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
----
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-----
20
PsiBlast_PDB
80.33
29%
-123
- C1 -
4YMV
1
?
J:
[16-236]
--------------------
V
L
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKINNGKVNINKVR
Q
---------------
K
--------------
V
-------------------------
G
M
V
F
Q
H
---------
F
N
LF
P
H
-
L
T
A
---
I
E
N
I
T
L
A
P
V
K
V
K
--
K
M
N
-----
K
K
E
A
E
-------------------
E
L
A
V
D
L
L
A
K
V
GLLDKKDQY
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
----
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-----
39
HHSearch
80.29
27%
-130
- C1 -
2YYZ
3
?
A:
[4-228]
-
I
R
V
V
N
L
K
K
Y
F
G
-----
K
V
K
A
V
D
G
V
S
---
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
--------------
V
---------------
L
VNDIPPKYRE----
V
-------------------------
G
M
V
F
Q
N
Y
A
-------
L
Y
--
P
H
-
M
T
V
---
F
E
N
I
A
F
P
L
R
A
R
R
--
I
-------
S
K
D
E
V
E
K
R
---
V
V
E
I
A
R
K
L
-----
L
I
D
-
N
L
L
D
R
K
---------
P
-----------
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
----
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
-----
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
-----------
36
HHSearch
79.84
29%
-119
- C1 -
1OXX
22
?
K:
[3-239]
R
I
I
V
K
N
V
S
K
V
F
K
K
G---
K
V
V
A
L
D
N
V
N
---
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------------
R
---------------
L
--------------
V
ASNGKLIVPPEDRKI----------
G
M
V
F
Q
T
W
--
A
-----
L
Y
--
P
N
-
L
T
A
---
F
E
N
I
A
F
P
L
T
N
M
K
--
M
-------
S
K
E
E
I
R
K
R
---
V
E
E
V
A
K
I
L
-----
D
I
H
-
H
V
L
N
H
F
---------
P
-----------
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
----
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
-----
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
-------
6
PsiBlast_PDB
79.41
30%
-121
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-226]
-
I
K
V
E
N
V
S
F
I
Y
N
E
GTPY
A
T
V
A
L
K
D
I
N
---
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
IDITDKKVS
L
K
D
I
R
K
---------------
Q
--------------
V
-------------------------
G
L
V
F
Q
Y
-------------
P
E
-
Y
Q
L
FE-
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
S
-----
E
E
E
V
K
E
R
----
V
Y
E
A
M
E
I
V
-----
G
I
S
K
E
L
A
D
K
S
---------
P
-----------
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
----
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
-----
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
---------------------------
33
HHSearch
78.42
28%
-121
- C1 -
2IT1
-
?
A:
[4-234]
-
I
K
L
E
N
I
V
K
K
F
G
-----
N
F
T
A
L
N
N
I
N
---
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
--------------
K
DVTELPPKDR-----
N
--------------
V
-------------------------
G
L
V
F
Q
N
W
--
A
-----
L
Y
--
P
H
-
M
T
V
---
Y
K
N
I
A
F
P
L
E
L
R
K
--
A
-------
P
R
E
E
I
D
K
K
---
V
R
E
V
A
K
M
L
-----
H
I
D
-
K
L
L
N
R
Y
---------
P
-----------
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
----
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
-----
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-----
48
HHSearch
77.60
25%
-127
- C1 -
1B0U
4
HISP_SALTY
A:
[7-255]
-
L
H
V
I
D
L
H
K
R
Y
G
-----
G
H
E
V
L
K
G
V
S
---
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
--------------
Q
---------------
N
--------------
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
-------
L
W
--
S
H
-
M
T
V
---
L
E
N
V
M
E
A
P
I
Q
V
L
--
G
L
------
S
K
H
D
A
R
E
R
---
A
L
K
Y
L
A
K
V
-----
G
I
D
E
R
A
Q
G
K
Y
---------
P
-----------
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
----
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
-----
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
---
31
HHSearch
76.98
25%
-125
- C1 -
1Z47
1
?
A:
[15-247]
-
I
E
F
V
G
V
E
K
I
Y
P
G
----
G
A
R
S
V
R
G
V
S
---
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
--------------
K
RVTDLPPQKR-----
N
--------------
V
-------------------------
G
L
V
F
Q
N
Y
A
-------
L
F
--
Q
H
-
M
T
V
---
Y
D
N
V
S
F
G
L
R
E
K
R
--
V
-------
P
K
D
E
M
D
A
R
---
V
R
E
L
L
R
F
M
-----
R
L
E
-
S
Y
A
N
R
F
---------
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
----
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
-----
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
----
2
PsiBlast_PDB
76.95
31%
-131
- C1 -
4RY2
-
?
A:
[489-724]
-
I
E
F
R
N
V
D
F
R
Y
G
L
----
R
K
P
V
L
K
N
I
N
---
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
--------------
H
---------------
S
--------------
I
KNIS---------------------
L
E
L
I
R
K
K
I
A
F
-----
V
S
--
Q
D
V
F
I
F
---
S
G
T
V
K
E
N
L
C
L
G
-----
N
-----
E
N
V
D
M
D
E
I
---
I
--
K
A
A
K
M
-----
A
N
A
H
D
F
I
E
K
L
---------
P
LKYDTFLNESG
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
----
K
D
A
I
Y
G
--
L
E
D
D
V
T
-----
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
---
13
PsiBlast_PDB
76.44
25%
-131
- C1 -
3TUI
1
METN_ECOLI
C:
[24-266]
M
I
K
L
S
N
I
T
K
V
F
H
Q
----
G
T
R
T
I
Q
A
L
N
NVS
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
--------------
Q
---------------
E
--------------
L
-------------------------
T
T
L
S
E
S
E
L
T
K
-----
A
R
--
R
Q
-
I
G
M
IFQ
H
F
N
L
L
S
S
R
T
V
F
G
--
N
V
A
LPLEL
D
N
T
P
K
D
E
V
KRR
V
T
E
L
L
S
L
V
-----
G
L
G
D
K
H
-
D
S
Y
---------
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
----
L
E
L
L
K
-----
D
I
N
R
RLGLT
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
---
37
HHSearch
76.00
27%
-132
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-235]
S
V
Q
L
Q
N
V
T
K
A
W
G
-----
E
V
V
V
S
K
D
I
N
---
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
--------------
K
RMNDTPPAER-----
G
--------------
V
-------------------------
G
M
V
F
Q
S
Y
--
A
-----
L
Y
--
P
H
-
L
S
V
---
A
E
N
M
S
F
G
L
K
L
A
G
--
A
-------
K
K
E
V
I
N
Q
R
---
V
N
Q
V
A
E
V
L
-----
Q
L
A
-
H
L
L
D
R
K
---------
P
-----------
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
----
R
I
E
I
S
R
L
H
K
R
L
G
R
T
-----
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
----
14
PsiBlast_PDB
75.48
25%
-129
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-266]
M
I
K
L
S
N
I
T
K
V
F
H
Q
----
G
T
R
T
I
Q
A
L
N
NVS
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
--------------
Q
---------------
E
--------------
L
-------------------------
T
T
L
S
E
S
E
L
T
K
-----
A
R
--
R
Q
-
I
G
M
IFQ
H
F
N
L
L
S
S
R
T
V
F
G
--
N
V
A
LPLEL
D
N
T
P
K
D
E
V
KRR
V
T
E
L
L
S
L
V
-----
G
L
G
D
K
H
-
D
S
Y
---------
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
----
L
E
L
L
K
-----
D
I
N
R
RLGLT
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
---
4
PsiBlast_PDB
74.99
31%
-128
- C1 -
4S0F
2
?
A:
[489-724]
-
I
E
F
R
N
V
D
F
R
Y
G
L
----
R
K
P
V
L
K
N
I
N
---
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
--------------
H
---------------
S
--------------
I
KNIS---------------------
L
E
L
I
R
K
K
I
A
F
-----
V
S
--
Q
D
V
F
I
F
---
S
G
T
V
K
E
N
L
C
L
G
-----
N
-----
E
N
V
D
M
D
E
I
---
I
--
K
A
A
K
M
-----
A
N
A
H
D
F
I
E
K
L
---------
P
LKYDTFLNESG
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
----
K
D
A
I
Y
G
--
L
E
D
D
V
T
-----
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
---
32
HHSearch
73.74
26%
-131
- C1 -
1V43
-
?
A:
[13-250]
-
V
K
L
E
N
L
T
K
R
F
G
-----
N
F
T
A
V
N
K
L
N
---
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
--------------
R
---------------
D
VTYLPPKDRN----
I
-------------------------
S
M
V
F
Q
---------------
H
-
M
T
V
---
Y
E
N
I
A
F
P
L
--
K
K
--
F
-------
P
K
D
E
I
D
K
R
---
V
R
W
A
A
E
L
L
-----
Q
I
E
-
E
L
L
N
R
Y
---------
P
-----------
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
----
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
-----
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
----
21
PsiBlast_CBE
73.16
31%
-130
- C1 -
4S0F
2
?
B:
[489-724]
-
I
E
F
R
N
V
D
F
R
Y
G
L
----
R
K
P
V
L
K
N
I
N
---
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
--------------
H
---------------
S
--------------
I
KNIS---------------------
L
E
L
I
R
K
K
I
A
F
-----
V
S
--
Q
D
V
F
I
F
---
S
G
T
V
K
E
N
L
C
L
G
-----
N
-----
E
N
V
D
M
D
E
I
---
I
--
K
A
A
K
M
-----
A
N
A
H
D
F
I
E
K
L
---------
P
LKYDTFLNESG
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
----
K
D
A
I
Y
G
--
L
E
D
D
V
T
-----
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
---
38
HHSearch
72.90
27%
-116
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-243]
-
L
H
I
G
H
L
S
K
S
F
Q
-----
N
T
P
V
L
N
D
I
S
---
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
--------------
K
---------------
T
IFSKN
T
N
L
P
VRERR
L
-------------------------
G
Y
L
V
Q
E
G
V
-------
L
F
--
P
H
-
L
T
V
---
Y
R
N
I
A
Y
G
L
G
N
G
K
--
G
-------
R
T
A
Q
E
R
Q
R
---
I
E
A
M
L
E
L
T
-----
G
I
S
-
E
L
A
G
R
Y
---------
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
----
R
E
D
M
I
A
A
L
R
A
N
G
K
S
-----
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
------
10
PsiBlast_PDB
66.12
31%
-116
- C1 -
3QF4
1
Y288_THEMA
B:
[355-569]
-
I
E
F
K
N
V
W
F
S
Y
D
K
----
K
K
P
V
L
K
D
I
T
---
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
--------------
I
---------------
D
--------------
I
-------------------------
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
-
I
L
F
---
S
T
T
V
K
E
N
L
K
Y
G
N
P-
G
A
T
-----
D
E
E
I
K
E
A
A
---
K
L
T
H
S
D
H
F
I
K
H
LP
E
G
Y
E
T
V
L
T
D
N
---------
G
-----------
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
-----------
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
-------------------------
11
PsiBlast_PDB
65.88
31%
-120
- C1 -
4Q4A
1
Y288_THEMA
B:
[355-569]
-
I
E
F
K
N
V
W
F
S
Y
D
K
----
K
K
P
V
L
K
D
I
T
---
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
--------------
I
---------------
D
--------------
I
-------------------------
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
-
I
L
F
---
S
T
T
V
K
E
N
L
K
Y
G
N
P-
G
A
T
-----
D
E
E
I
K
E
A
A
---
K
L
T
H
S
D
H
F
I
K
H
LP
E
G
Y
E
T
V
L
T
D
N
---------
G
-----------
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
-----------
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
-------------------------