@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1747: (2016-03-28 )
MNAIELSNVNYSSDQFNLKNISFKVPQGFVTGFIGRNGAGKTTIIRLIMDLYQPQTGVIRVLEEDMALNPIELKNSIGFVYSENYFNERWTTKQLEKMIAPFYRKWDHQVFEFYLEKFDLPINKSIKTFSTGMKMKLSLAVAFSHHAELYIFDEPTSGLDPLARNELLEIIQQELIDENKTIFMSTHIISDLEKIADYIIHLSDGEVILNGSKEQLLQRYQVVSGATEDLDDELASLLIYEEHKRTGFIGLTEHAQVFKEILGHKVNITTPSIENLMVYLEKRKPKYHENIKLMEEGF
Atome Classification :
(21 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.----.--.-----.....20........30........40........50....---....---60.....----.-.--------------.----70.-.-.......80---------....-----.-....-90.----......---------------.100----..--------.---.----.---..-.110.......-120---.-------------.-------------...---....130.......140.......150.......160.......170.......180.......190...--...--.200.......210.......----220.......230.......240..---------------.....250.......260..---.....270...--------....280.......290......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN
A
I
E
LSNVNYS----S--D-----QFNLKN
I
S
F
KV
P
Q
G
F
V
T
G
FIGRNGA
G
K
T
T
I
I
R
L
I
M
D
L
YQPQ---
T
G
V
I
---
R
V
L
E
E
DM----A-L--------------N----
P
-
I
-
E
-LKNSI
G
F
V
----------
Y
SEN-----Y-FNER-W
T
T
----
K
Q
L
E
K
M
---------------
I
A
P
-----
F
Y
--------
R
---
K
----
W
---
D
H
-
Q
V
F
E
F
Y
L
E
K
FD-L-----P-------------I-------------NKS---
I
K
T
FSTG
M
K
M
K
L
S
L
A
V
A
FSHH
A
E
L
Y
I
F
DEPTSGLD
P
L
A
R
N
E
L
L
E
I
I
Q
Q
E
LIDEN
K
T
I
F
M
S
T
H
I
I
S
D
L
E
K
I
--
A
D
Y
--
I
I
HLSDG
E
V
I
LNG
S
K
E
Q
L
L
Q
R
----
Y
Q
VVSGATE
D
L
D
D
E
L
A
S
L
L
I
Y
E
EHK---------------RTGFIG
L
T
E
H
A
Q
V
F
K
E
I
LG
H
---
K
V
NITTP
S
I
E
N
--------
L
M
V
Y
L
E
KRKP
K
Y
H
EN
I
K
L
M
EEGF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
89.89
32%
-100
- C1 -
1VPL
2
?
A:
[14-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
V
V
V
K
D
L
R
K
R
----
I
G-
K
-----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
---
S
G
I
V
---
T
V
F
G
K
N
V
----
V
-
E
--------------
E
----
P
-
H
-
E
-
V
R
K
L
I
S
Y
L
----------
P
E
E
A
-----
G
-
A
Y
R
N
-
M
Q
G
----
I
E
Y
L
R
F
---------------
V
A
G
-----
F
Y
--------
A
---
S
----
S
S
S
E
I
E
-
E
M
V
E
R
A
T
E
I
A
G
-
L
-----
G
EK-----------
I
-------------
K
D
R
---
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
--
C
D
R
--
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
----
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.49
28%
-103
- C1 -
4RVC
-
?
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
E
V
K
D
L
S
G
G
Y---
T
--
A
-----
Q
N
V
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
---
R
G
A
I
---
S
I
N
G
Y
R
L
----
A
-
D
--------------
G
----
P
-
E
-
T
-
Y
R
R
Q
F
A
Y
I
----------
P
E
T
P
-----
V
-
L
Y
E
E
-
L
T
L
----
E
E
H
L
R
L
---------------
A
A
M
-----
A
Y
GLS
E
A
E
Y
E
R
---
R
----
L
---
P
P
-
L
L
R
E
F
R
L
E
R
R
----------------------
L
-------------
S
S
F
---
P
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
R
M
N
E
Q
K
A
-
K
G
A
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
--
C
D
S
--
F
V
I
L
H
N
G
R
V
K
A
K
G
T
L
D
D
I
R
R
Q
----
F
G
L
R
G
A
S
L
D
E
L
Y
V
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
81.45
22%
-80
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKI
K
G
D
I
T
V
E
N
V
H
F
T
Y
PSR
P
--
D
-----
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
---
T
I
D
G
V
D
V
R---
D
-
I
--------------
N
----
L
-
E
-
F
-
L
R
K
N
V
A
V
V
----------
S
Q
E
P
A
L
F
NC
T
-
I
E
E
N
-
I
S
L
G
KEG
I
T
R
E
E
M
---------------
V
A
A
-----
C
K
--------
M
---
A
----
N
---
A
E
-
K
F
I
K
T
L
P
N
G
Y
N
-
T
-----
L
-------------
V
-------------
G
D
R
---
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
-----
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
RN
A
D
L
--
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
--------
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
---------------
E
G
E
R
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
N
---
N
A
Q
K
T
-----
N
--------
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
43
Fugue
81.00
24%
-87
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------------------------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRA
T
G
D
L
E
F
R
N
V
T
F
T
Y
PG-
R
--
E
-----
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
---
L
M
D
G
H
D
L
----
R
E
Y
--------------
T
----
L
-
A
-
S
-
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
NDT
V
A
N
N
-----
I
-
A
Y
A
R
-
T
E
E
----
Y
S
R
E
Q
I
---------------
E
E
A
-----
A
R
--------
M
---
A
----
Y
---
A
M
-
D
F
I
N
K
M
D
N
G
L
D
-
T
-----
I
-------------
I
-------------
G
E
N
---
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
---
A
D
E
--
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
----------------------------------------------------------------------------------------------
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
80.60
22%
-93
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
----
F
--
H
QGTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
---
L
V
D
G
Q
E
L
TTLS
E
-
S
--------------
E
----
L
-
T
-
K
-
A
R
R
Q
I
G
M
I
----------
F
Q
H
F
-----
N
-
L
L
S
S
-
R
T
V
----
F
G
N
V
A
L
---------------
P
L
E
-----
L
D
--------
N
---
T
----
P
---
K
D
-
E
V
K
R
R
V
T
E
L
L
S
-
L
VGLGD
K
-------------
H
-------------
D
S
Y
---
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
--
C
D
C
--
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
----
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
ERLQAEPFTDCVPML
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
FNV
N
N
N
I
I
S
A
Q
M
D
Y
AGGVKFGI
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
VKVEV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.66
32%
-96
- C1 -
1VPL
2
?
A:
[31-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
---
S
G
I
V
---
T
V
F
G
K
N
V
----
V
-
E
--------------
E
----
P
-
H
-
E
-
V
R
K
L
I
S
Y
L
----------
P
E
E
A
-----
G
-
A
Y
R
N
-
M
Q
G
----
I
E
Y
L
R
F
---------------
V
A
G
-----
F
Y
--------
A
---
S
----
S
---
S
S
-
E
I
E
E
M
V
E
R
A
T
E
-
I
-----
A
GLGEK--------
I
-------------
K
D
R
---
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
--
C
D
R
--
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
----
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
78.29
26%
-106
- C1 -
1B0U
4
HISP_SALTY
A:
[5-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
H
V
I
D
L
H
K
R
----
Y
G-
G
-----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
---
E
G
A
I
---
I
V
N
G
Q
N
I
----
N
-
L
V
R
D
KDGQLKVAD
K
N
Q
----
L
-
R
-
L
-
L
R
T
R
L
T
M
V
----------
F
Q
H
F
-----
N
-
L
W
S
H
-
M
T
V
----
L
E
N
V
M
E
---------------
A
P
I
-----
Q
V
L-------
G
LS
K
H
----
D
---
A
R
-
E
R
A
L
K
Y
L
A
K
V
G
-
I
-----
D
ERA----------
Q
-------------
G
K
Y
---
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
--
S
S
H
--
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
----
P
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.15
24%
-102
* C1 *
2OLJ
4
?
A:
[22-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
----
F
G-
S
-----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
---
I
I
D
G
I
N
L
----
K
-
A
KDT-----------
N
----
L
-
N
-
K
-
V
R
E
E
V
G
M
V
----------
F
Q
R
F
-----
N
-
L
F
P
H
-
M
T
V
----
L
N
N
I
T
L
---------------
A
P
M
-----
K
V
--------
R
---
K
WP
R
E
K
---
A
E
-
A
K
A
M
E
L
L
D
K
V
G
-
L
-----
K
DK-----------
A
-------------
H
A
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.59
29%
-106
- C1 -
4YMS
-
?
J:
[17-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
FID
G
V
K
I
N
N
G
----
K
-
V
--------------
N
----
I
-
N
-
K
-
V
R
Q
K
V
G
M
V
----------
F
Q
-------
H
-
F
N
L
F
-
P
H
L
----
T
A
I
E
N
I
T--------------
L
A
P
VKVKK
M
N
--------
K
---
K
----
E
---
A
E
-
E
L
A
V
D
L
L
A
K
V
G
-
L
-----
L
-------------
D
-------------
K
K
D
QYP
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
----
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
73.56
27%
-102
- C1 -
1JI0
1
?
A:
[5-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
E
V
Q
S
L
H
V
Y
----
Y
G-
A
-----
I
H
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
---
K
G
K
I
---
I
F
N
G
Q
D
I
----
T
-
N
--------------
K
----
P
A
H
V
I
-
N
R
M
G
I
A
L
V
----------
P
E
G
R
-----
R
-
I
F
P
E
-
L
T
V
----
Y
E
N
L
M
M
---------------
G
A
Y
-----
N
R
--------
K
---
D
K
E
--
G
---
I
K
-
R
D
L
E
W
I
F
S
L
F
P
R
L
-----
K
E
R
-----------
L
-------------
K
Q
L
---
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
-
E
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
--
A
H
Y
--
G
Y
V
L
E
T
G
Q
I
V
L
E
G
K
A
S
E
L
L
D
N
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.77
29%
-109
- C1 -
4YMW
-
?
J:
[17-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
FID
G
V
K
I
N
N
G
----
K
-
V
--------------
N
----
I
-
N
-
K
-
V
R
Q
K
V
G
M
V
----------
F
Q
-------
H
-
F
N
L
F
-
P
H
L
----
T
A
I
E
N
I
T--------------
L
A
P
VKVKK
M
N
--------
K
---
K
----
E
---
A
E
-
E
L
A
V
D
L
L
A
K
V
G
-
L
-----
L
-------------
D
-------------
K
K
D
QYP
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
----
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.75
24%
-102
- C1 -
3TUI
1
METN_ECOLI
C:
[23-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
----
F
H-
Q
GTRT-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
---
L
V
D
G
Q
E
L
----
T
-
T
--------------
L
SESE
L
-
T
-
K
-
A
R
R
Q
I
G
M
I
----------
F
Q
H
F
-----
N
-
L
L
S
S
-
R
T
V
----
F
G
N
V
A
L
---------------
P
L
E
-----
L
D
--------
N
---
T
PKD-
E
---
V
K
-
R
R
V
T
E
L
L
S
L
V
G
-
L
-----
G
DK-----------
H
-------------
D
S
Y
---
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
--
C
D
C
--
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.51
29%
-108
- C1 -
4YMV
1
?
J:
[17-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
FID
G
V
K
I
N
N
G
----
K
-
V
--------------
N
----
I
-
N
-
K
-
V
R
Q
K
V
G
M
V
----------
F
Q
-------
H
-
F
N
L
F
-
P
H
L
----
T
A
I
E
N
I
T--------------
L
A
P
VKVKK
M
N
--------
K
---
K
----
E
---
A
E
-
E
L
A
V
D
L
L
A
K
V
G
-
L
-----
L
-------------
D
-------------
K
K
D
QYP
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
----
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.30
29%
-107
- C1 -
4YMT
-
?
J:
[17-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
FID
G
V
K
I
N
N
G
----
K
-
V
--------------
N
----
I
-
N
-
K
-
V
R
Q
K
V
G
M
V
----------
F
Q
-------
H
-
F
N
L
F
-
P
H
L
----
T
A
I
E
N
I
T--------------
L
A
P
VKVKK
M
N
--------
K
---
K
----
E
---
A
E
-
E
L
A
V
D
L
L
A
K
V
G
-
L
-----
L
-------------
D
-------------
K
K
D
QYP
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
----
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.97
29%
-106
- C1 -
4YMU
2
?
J:
[17-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
FID
G
V
K
I
N
N
G
----
K
-
V
--------------
N
----
I
-
N
-
K
-
V
R
Q
K
V
G
M
V
----------
F
Q
-------
H
-
F
N
L
F
-
P
H
L
----
T
A
I
E
N
I
T--------------
L
A
P
VKVKK
M
N
--------
K
---
K
----
E
---
A
E
-
E
L
A
V
D
L
L
A
K
V
G
-
L
-----
L
-------------
D
-------------
K
K
D
QYP
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
--
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
----
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
70.69
24%
-88
- C1 -
1Z47
1
?
A:
[13-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
E
F
V
G
V
E
K
I
----
Y
PG
G
-----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
---
K
G
D
V
---
W
I
G
G
K
R
V
----
T
-
D
--------------
L
----
P
---
P
-
Q
K
R
N
V
G
L
V
----------
F
Q
N
Y
-----
A
-
L
F
Q
H
-
M
T
V
----
Y
D
N
V
S
F
---------------
G
L
R
-----
E
K
--------
R
---
V
P
K
D
-
E
---
M
D
-
A
R
V
R
E
L
L
R
F
M
R
-
L
-----
E
SY-----------
A
-------------
N
R
F
---
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
--
A
D
R
--
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
----
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.27
28%
-77
- C1 -
4MYC
-
ATM1_YEAST
A:
[347-581]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
H
----
P
--
D
-----
R
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
---
L
I
N
G
R
D
I
----
K
-
E
--------------
Y
----
D
-
I
-
D
A
L
R
K
V
I
G
V
V
----------
P
Q
D
T
P
----
L
-
F
N
D
T
I
W
E
N
----
V
K
F
G
R
I
DAT
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
-----
L
I
--------
K
---
K
----
L
---
P
---------
Q
G
F
D
-
T
-----
I
-------------
V
-------------
G
E
R
---
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
T
S
G
S
R
T
---
S
V
Y
I
A
H
R
L
R
T
I
--
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
PGS
L
Y
R
E
L
W
T
I
Q
E
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
70.02
24%
-96
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
L
K
V
E
E
L
N
Y
N
----
Y
S-
D
G----
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
---
S
G
R
I
---
L
F
D
N
K
P
I
----
D
-
Y
S
R
K
-----------
G
----
I
-
M
-
K
-
L
R
E
S
I
G
I
V
----------
F
Q
D
P
-----
D
N
Q
L
F
S
-
A
S
V
----
Y
Q
D
V
S
F
---------------
G
A
V
-----
N
M
--------
K
LP
E
D
----
E
---
I
R
-
K
R
V
D
N
A
L
K
R
T
G
-
I
-----
E
HL-----------
K
-------------
D
K
P
---
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
--
C
D
N
--
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
----
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
69.84
24%
-98
- C1 -
3ZDQ
-
ABCBA_HUMAN
A:
[341-571]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
F
K
N
V
H
F
A
----
Y
P-
A
RPE--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
---
S
L
D
G
H
D
I
----
R
-
Q
L-------------
N
----
P
-
V
-
W
-
L
R
S
K
I
G
T
V
----------
S
Q
E
P
-----
I
-
L
F
S
C
--
S
I
----
A
E
N
I
A
Y
---------------
G
A
D
-----
D
P
--------
S
---
S
----
V
---
T
A
-
E
E
I
Q
R
V
A
E
V
A
N
-
A
-----
V
A
F
I
R
N
FPQGFN
T
V
V
-------------
G
E
K
---
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
-
N
--
A
N
M
--
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.26
25%
-91
- C1 -
3WMG
1
?
A:
[350-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
V
F
E
N
V
H
F
R
----
Y
P-
T
RMN--
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
---
L
F
D
G
T
P
A
----
W
-
N
Y-------------
D
----
F
-
H
-
A
-
L
R
S
Q
I
G
L
V
----------
S
Q
E
P
-----
V
-
L
F
S
G
--
T
I
----
R
D
N
I
L
Y
---------------
G
K
R
-----
D
A
---------------------
T
D
-
E
E
V
I
Q
A
L
R
E
A
N
-
A
-----
Y
S
F
V
M
A
LPDGLD
T
E
V
-------------
G
E
R
---
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
-
R
--
A
D
L
--
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
36.57
30%
-12
- C1 -
4YER
4
?
A:
[21-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
---
S
G
K
A
---
W
V
A
G
H
D
V
----
L
-
K
--------------
E
----
P
-
R
-
E
-
V
R
R
K
I
G
I
V
----------
F
Q
D
--------------------
Q
S
L
D
R
E
---------------
L
T
A
-----
Y
E
--------
N
---
M
----
Y
---
I
H
G
K
I
Y
G
Y
G
G
E
K
L
K
-
K
-----
R
-------------
I
L
E
L
L
E
F
V
ELLEFK
D
K
P
---
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
--
A
D
R
--
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------