@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2149: (2016-04-01 )
MALVVKDIVKNFGEGLSETKVLKGINFEVEQGEFVILNGASGSGKTTLLTILGGLLSQTSGTVLYNDAPLFDKQHRPSDLRLEDIGFIFQSSHLVPYLKVIEQLTLVGQEAGMTKQQSSTRAIQLLKNIGLEDRLNVYPHQLSGGEKQRVAIMRAFMNNPKIILADEPTASLDADRATKVVEMIRQQIKEQQMIGIMITHDRRLFEYADRVIELEDGKITD
Atome Classification :
(40 SA)
-.........10........20........30........40........50........60.....--...70..-...-....80........90........100--....-...110.-.---......120.......130.-..-.--------...140--........150.......160.......170.......180.......190..--------.....200-...-....210.......220----------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
A
L
V
V
K
D
I
V
K
N
F
G
E
G
L
S
E
T
K
V
LKGI
N
F
E
V
EQG
E
F
V
I
L
NGASGSG
K
T
T
L
L
T
I
L
G
G
L
L
SQTS
G
T
V
L
YN--DAPL-FD-KQH-RPSDL
R
L
E
D
I
G
F
I
F
QSSHL
V
P
Y
L
K
V
I
E
--
Q
L
T
L
-
V
G
QEA-G-M---TKQQS
S
T
R
A
I
Q
L
L
K
NIGLED-RL-N--------VYPHQ---LSGG
E
K
Q
R
V
A
I
M
R
A
F
MNNP
K
I
I
L
ADEPTASL
D
A
D
R
A
T
K
V
V
E
M
I
R
Q
Q
I
K
EQQ
M
I
--------
G
I
M
I
THD
R
-
R
L
F
-
E
Y
A
D
R
V
I
E
LEDGKITD-----------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
85.71
36%
-102
- C1 -
3TIF
7
Y796_METJA
A:
[1-224]
--
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
I
K
T
-
N
D
-
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
V
E
L
-
P
L
I
F
K
-
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
--------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
--------
V
V
V
V
T
H
D
I
-
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.54
36%
-112
- C1 -
4YMV
1
?
A:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
84.49
39%
-104
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[3-218]
-
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
--
G
K
E
V
-
D
Y
-
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
--
N
V
I
V
-
P
M
L
K
M
-
G
-
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
-
S
--------
R
K
P
Y
E
---
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
G
T
S
--------
I
V
M
V
T
H
E
R
-
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.08
36%
-112
- C1 -
4YMV
1
?
J:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.05
37%
-103
- C1 -
1L2T
4
Y796_METJA
B:
[4-223]
-----
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
I
K
T
-
N
D
L
D
D
D
-
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
NV
E
L
P
L
-
I
F
K
Y
R
-
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
--------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
--------
V
V
V
V
T
H
D
I
-
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
83.97
36%
-107
* C1 *
2OLJ
4
?
A:
[24-238]
--
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
--
G
I
N
L
-
K
A
-
K
D
T
-
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
I
T
L
-
A
P
M
K
V
-
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
--------
A
Y
P
D
S
---
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.80
36%
-112
- C1 -
4YMU
2
?
J:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.85
36%
-115
- C1 -
4YMS
-
?
J:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.69
36%
-116
- C1 -
4YMW
-
?
J:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.63
37%
-105
- C1 -
3TIF
7
Y796_METJA
B:
[4-223]
-----
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
I
K
T
-
N
D
L
D
D
D
-
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
NV
E
L
P
L
-
I
F
K
Y
R
-
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
--------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
--------
V
V
V
V
T
H
D
I
-
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
82.19
34%
-103
- C1 -
4U00
3
?
A:
[7-218]
---------
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
--
G
L
S
V
-
K
D
-
D
R
A
-
L
-
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
--
N
V
T
L
-
A
P
M
R
V
-
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
-
R
--------
K
Y
P
A
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
-
D
L
A
Q
G
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.84
37%
-100
- C1 -
3TIF
7
Y796_METJA
A:
[4-223]
-----
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
I
K
T
-
N
D
L
D
D
D
-
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
Y
R
-
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
--------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
--------
V
V
V
V
T
H
D
I
-
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.82
36%
-111
- C1 -
4YMU
2
?
A:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.73
36%
-111
- C1 -
4YMT
-
?
J:
[2-216]
---
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
-
N
N
-
G
K
V
-
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
I
T
L
-
A
P
V
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
--------
Q
Y
P
I
K
---
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.93
37%
-102
- C1 -
1L2T
4
Y796_METJA
A:
[4-223]
-----
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
I
K
T
-
N
D
L
D
D
D
-
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
Y
R
-
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
--------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
--------
V
V
V
V
T
H
D
I
-
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
80.53
34%
-109
- C1 -
3C4J
4
?
B:
[27-239]
-----
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
--
G
I
N
L
-
K
A
-
K
D
T
-
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
I
T
L
-
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
--------
A
Y
P
D
S
---
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
-----------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
79.71
34%
-101
- C1 -
4U02
1
?
C:
[7-218]
---------
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
--
G
L
S
V
-
K
D
-
D
R
A
-
L
-
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
--
N
V
T
L
-
A
P
M
R
V
-
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
-
R
--------
K
Y
P
A
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
-
D
L
A
Q
G
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
117
Fugue
79.55
29%
-98
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
--
D
R
L
V
-
A
S
-
N
G
K
-
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
--
N
I
A
F
-
P
L
T
N
M
-
K
-
M
---
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
-
N
--------
H
F
P
R
E
---
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
--------
L
L
V
V
S
H
D
P
A
D
I
F
-
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
VGKPEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
15
PsiBlast_PDB
79.42
34%
-107
- C1 -
3C4J
3
?
A:
[27-239]
-----
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
--
G
I
N
L
-
K
A
-
K
D
T
-
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
I
T
L
-
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
--------
A
Y
P
D
S
---
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
--------
M
V
V
V
T
H
E
M
-
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
-----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.36
41%
-102
- C1 -
2PCL
12
LOLD_AQUAE
A:
[18-217]
--------------------
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
--
G
K
E
V
D
Y
T
-
N
E
K
-
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
--
N
V
I
V
-
P
M
L
K
M
-
G
-
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
-
S
--------
R
K
P
Y
E
---
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
-
I
F
L
K
I
N
E
G
G
T
S
--------
I
V
M
V
T
H
E
R
-
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
-------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
73.41
31%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-223]
--
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
-
F
S
-
K
N
T
-
N
L
P
V
R
-
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
--
N
I
A
Y
-
G
L
G
N
G
-
K
-
G
---
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
-
G
--------
R
Y
P
H
E
---
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
--------
A
V
F
V
S
H
D
R
-
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.69
32%
-94
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-222]
--
A
L
H
I
G
H
L
S
K
S
F
----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
-
F
S
-
K
N
T
-
N
-
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
--
N
I
A
Y
G
L
G
N
G
K
-
G
-
R
---
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
-
G
--------
R
Y
P
H
E
---
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
--------
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
69.05
32%
-99
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-217]
--
A
L
H
I
G
H
L
S
K
S
F
----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
-
F
S
-
K
N
T
-
N
-
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
--
N
I
A
Y
G
L
G
N
G
K
-
G
-
R
---
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
-
G
--------
R
Y
P
H
E
---
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
--------
E
Q
L
R
R
Q
I
R
E
D
M
I
A
ALRANGKS
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.10
31%
-113
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.32
31%
-108
- C1 -
2FGK
2
D:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
58.75
31%
-118
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[18-217]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
58.38
31%
-114
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[18-217]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYN
T
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
58.28
31%
-107
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
58.02
31%
-111
- C1 -
2FGJ
2
D:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
57.59
31%
-113
- C1 -
1XEF
3
D:
[18-217]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
56.71
31%
-107
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
56.32
31%
-107
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.18
31%
-105
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
55.87
31%
-111
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYN
T
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
54.08
31%
-109
- C1 -
3B5J
1
A:
[20-219]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
53.82
31%
-111
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[18-217]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
ELREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
53.65
31%
-111
- C1 -
2PMK
1
A:
[20-219]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
52.83
31%
-107
- C1 -
2FFB
1
A:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
52.52
31%
-111
- C1 -
2FF7
1
A:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
H
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
52.49
31%
-107
- C1 -
2FFA
2
A:
[24-223]
---------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
GH
D
L
A
L
-
A
D
------
P
N
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
--
N
I
S
L
-
A
--
N
P
-
G
-
M
-------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
-
S
E
LREGYNT
I
V
G
E
Q
GAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
----------
I
I
I
A
A
R
L
-
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
-----------------------------------------------------------------------------------------------------------------------------------