@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0111: (2015-12-12 )
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAKQKIIELLENVDATEIDVLKIRSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADVAVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCLASLFTDRAISYRASRGFDHLKVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVFKPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKYAIEIEKHYSKEAKQYRPMDIEWAKDGESGEIFIVQARPETVQSQKTKEENQVFEKFKFKNPNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEILVTDNTDPDWEPCMKKASAVITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEIERVELSNMQETQTKIYINIGNPEKAFSFSQLPNHGVGLARMEMIILNQIKAHPLALVDLHHKKSVKEKNEIENLMAGYANPKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRMLGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALALVREEMGLTNMKVMIPFLRTIEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTLGVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGITSISLNPDSVIPTWNAVAKLEKELKDHGLTAR
Atome Classification :
(20 SA)
.........----10---.........20........30........40........50.....-----.-----.-----.----60.....----...70----.-----------------------------.------.---..-----...80.------.------.....--.90........100---------..----------..------...---..110-------------..------------------------------.------------------....-.------120.......130.--......-140.....-----..-------.-------150.......160.......170.......180......-----.190..---..---.---..---200.......210...--......220.......230.....-------------..240.......250...--...---------.260.......270.-----......280....---...---290-......---------------------...300.......310......-.320.......330...------..------.-------------.340--------.......350------------------------.---.--------...----..---------360-..-......370......------.380...-.-...390.-....---...--400.......--410...--....420.......430.......440.....-------.------------.450----------...--......460..----------.....470--------...---....-.-------480----------.----..-------.-------.---------------....-----490--------.----.--------......500.......510.......520....---..---.530........540.......550.......560.......570.....------..580...--....590..-..---..-------.------------600-------..-------------------.----.-.-------.--------.610----------........620..--.--......630.......640..---.----...-----.-650-----........660.-..----...---.670-....---..-----.----.-----680-.-.-----....----...690.......700.......710.......720..-------.-----------...--.-730-------.-------.-------..------.-----------.----..740-----........750--.--...------..--.760.......770.......780.......790.......800.......810
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
Y
I
K
F
F
K
E
----L----NNK
N
V
N
L
VGGKNA
S
I
G
E
M
F
Q
E
LVP
I
G
I
KVPD
G
F
A
IT
S
E
A
Y
W
Y
L
LEQ-----G-----G-----
A
----
K
Q
K
I
I
E
L
----
L
ENVD----A-----------------------------T------E---
I
D
-----
V
L
K
I
R
S
------
K
------
Q
I
R
E
L
--IFGTPF
P
S
D
L
R
D
-----------
E
I
----------
F
Q
------
A
Y
E
---
I
L
S
Q
--------------
Q
Y------------------------------H------------------MKEA-
D
------
V
A
VRSSATAEDLPD--ASFAGQ-QD-
T
Y
L
N
I-----KG-------
K
-------
T
E
L
I
H
Y
I
K
S
C
L
A
S
L
F
TDRAISYRASRGF
D
H
L
K
V
A
L
S
V
G
V
-----
Q
K
M
V
R
A---DK---G---SA---
G
V
M
F
S
IDTETG--FK
D
--
A
V
F
I
TSAWGLGENVVGGTI
N
P
D
E
F
-------------
Y
V
FKPTLEQNKR
P
I
I
K
R
Q
--LGN---------KT
Q
K
M
V
YAPRGSEHP-----TRNI
K
T
T
K
K
E
W
Q
S---FSL---S---DE
D
V
L
I
---------------------
L
A
K
Y
A
I
E
I
E
K
H
Y
S
K
E
A
K
QYRPM-D
I
E
WAKDGESG
E
I
F
I
V
Q------AR------P-------------E
T
V
Q
--------
S
QKT
K
E
E
N
Q
V
------------------------
F
---
E
--------
K
FK----FK---------N-P-N
E
-
K
K
E
I
I
L
QGRAIGSKI------GSG
K
V
R
I
-
I
-
N
D
L
E
H
-
M
-NSFK---EG
E
--
I
L
V
TDNTDP
D
--
W
E
P
C
M
K
--
K
A
S
A
V
ITNRGG
R
T
C
H
A
A
I
V
A
R
EIGV
P
A
I
V
GVS-------G------------AT------------DSL--YTG
M
E
I
T
V
S
CA----------EGEEG
Y
V
---------
Y
A
G
---
I
Y
EH-E-------
I
------------
E
----
R
V
-------
E
-------L---------------SNMQ-----ET---------
Q
----
T
--------
K
I
Y
I
N
IG
N
P
E
KAFSFSQLPNHGV
G
L
A
R
M
E
M
I
I
L
---
N
Q---IKA-H
P
L
A
L
V
D
LH
H
K
KSV
K
E
K
N
E
I
E
N
L
M
AGYA
N
P
K
D
F
F
V
K
K
I
A
E
G
I
G
M
I
S
------AAFYPK
P
V
--
I
V
RTSDFKS-
N
E
---
Y
M
-------
R
------------
M
LG-------GS-------------------S----Y-E-------P--------NEE-----------NPMLGYR
G
A
--
S
R
--
Y
--
Y
S
E
SYNEAFSW
E
C
E
A
L
A
L
V
R
E
---
E
----MGL-----T-
N
M
------
K
V
M
I
P
F
L
R
T
I
E
E
-
G
K
----
K
V
L
---
E
I
L
--
R
KNN---LE-----S----G-----K---N-
G
-----
L
E
I
Y
----
I
M
C
ELP
V
N
V
I
L
A
D
D
F
L
S
L
F
DGFSIGSN
D
L
T
Q
L
T
LGVDR-------
D
-----------
S
E
L
--
V
-
S
H
--------
V
-------
F
-------
D
E------
R
-----------
N
----
E
A
M
L
------
K
M
F
K
K
A
I
E
A
C
K
--R--HNK------YC--GICGQAPSD
Y
P
E
V
T
E
F
L
V
KEGI
T
S
ISLNPDSVIP
T
W
N
A
V
A
K
L
E
K
E
L
K
DHGLTAR
33
HHSearch
85.36
25%
-66
- C1 -
1VBG
4
PPDK1_MAIZE
A:
[3-875]
K
K
R
V
F
H
F
G
K
GKSE
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
----
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
CALP
A
-----
G
-----
L
----
W
A
E
I
V
D
G
----
L
Q
W
V
E
----
E
Y
M
GATLGDP--------------------
Q
------
R
---
P
L
-----
L
L
S
V
R
S
------
G
A
AVSMP
G
M
M
D
T
--
V
L
N
L
G
L
N
D
E
V
A
A
-----------
G
L
----------
A
A
KSG
E
R
F
A
Y
D
S
F
R
R
F
L
D
--------------
M
F
------------------------------
G
N
VVMDIP
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
-
G
------
L
K
N
D
T
D
L
T
A
S
D
L
K
----
E
L
V
G
Q
-
Y
K
E
V
Y
L
S
A
-----
K
G
-------
E
PFPSD
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
-
L
R
G
T
A
V
N
V
-----
Q
C
M
V
F
G
---
N
M
GNT
S
---
G
T
---
G
V
L
F
T
R
N
P
N
T
G
--
E
K
K
--
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
-------------
D
A
M
K
-----------------------------------------------------------------
N
L
---
M
---
P
Q
A
Y
D
E
---------------------
L
V
E
N
C
N
I
L
E
S
H
Y
K
------
E
M
Q
-
D
I
E
F
T
V
Q
--
E
N
R
L
W
M
L
Q
------
C
R
------
T
-------------
G
K
R
T
--------
G
K
S
A
V
K
-
I
A
V
D
M
V
N
E
GLVE
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
---
L
--------
H
P
Q
----
F
E
---------
N
-
P
S
A
Y
-
K
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
------
A
V
G
Q
V
V
F
-
T
-
A
E
D
A
E
A
W
-
H
S
Q
G
---
K
A
A
--
I
L
V
R
A
E
T
S
P
E
--
D
V
G
G
M
H
--
A
A
V
G
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
-------
G
------------
I
R
VNDAEK
L
V
T
I
GG
H
V
L
--
R
E
G
E
W
L
---
S
L
----------
N
G
S
T
G
E
V
---------
I
L
G
---
K
Q
P
L
-
S
-------
P
------------
P
----
A
L
SG
D
L
G
T
F
M
-------
A
---------------
W
V
D
D
-----
V
R
---------
K
----
L
--------
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
---
A
S
----
D
E
-
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
----------
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
------
R
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
-
H
E
---
F
L
-------
P
------------
E
G
N
-------
I
E
D
I
V
S
E
L
C
A
E
TGAN
Q
E
D
A
L
A
R
----
I
E
K
-------
L
--------
S
E
V
-----------
N
P
M
L
G
F
R
G
C
--
R
L
--
G
--
I
S
Y
--
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
---
A
M
T
N
-
Q
G
V
Q----
V
-
F
P
------
E
I
M
V
P
L
V
G
T
P
Q
E
-
L
G
----
H
Q
V
---
T
L
I
--
R
Q
V
A
---
E
K
V
F
A
N
V
G
----
K
-----
T
---
I
-
G
-----
Y
K
V
G
----
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-------
D
-----------
D
V
G
--
K
F
I
P
V
Y
L
A
Q
GIL
Q
-------
H
-------
D
P
------
F
-----------
E
VLDQ
R
G
V
G
------
E
L
V
K
F
A
T
E
R
G
R
--
K
A
R
P
N
L
------
K
V
--
G
I
C
G
E
H
G
G
-
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
----------
32
HHSearch
83.22
25%
-61
- C1 -
1KBL
6
PPDK_CLOSY
A:
[1-872]
A
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
----
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
----
I
T
W
L
E
----
E
L
N
GKKF-----------------------
G
------
D
T
E
D
P
L
-----
L
V
S
V
R
S
------
G
A
R
A
S
M
P
G
M
M
D
T
--
I
L
N
L
G
L
N
D
V
A
V
E
-----------
G
F
A
K
K
T
GN
P
R
F
A
Y
D
------
S
Y
R
---
R
F
I
Q
--------------
M
Y
------------------------------
S
D
VVMEVPK
S
H
F
E
K
I
I
D
A
M
K
E
E
K
-
G
------
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
K
-
E
A
M
N
G
EEFPQ
E
P
-------
K
-------
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
-
D
W
G
T
A
V
N
V
-----
Q
T
M
V
F
G
---
N
K
GET
S
---
G
T
---
G
V
A
F
T
R
N
P
S
T
G
--
E
K
G
--
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
-------------
T
Q
L
E
N
-----------------------------------------------------------------
D
---
M
---
P
D
C
Y
K
Q
---------------------
F
M
D
L
A
M
K
L
E
K
H
F
R
------
D
M
Q
-
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
------
T
R
------
N
-------------
G
K
R
T
--------
A
P
A
A
L
-
Q
I
A
C
D
L
V
D
E
GMIT
E
E
E
A
V
V
R
IEAKS---
L
DQL
L
--------
H
P
T
----
F
N
P
--------
A
-
A
-
L
K
-
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
------
A
A
G
K
V
Y
F
-
T
-
A
D
E
A
K
-
A
A
H
E
K
G
---
E
R
V
--
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
-------
E
------------
I
K
INEEAK
T
F
E
L
GG
H
T
F
--
A
E
G
D
Y
I
---
S
L
----------
D
G
S
T
G
K
I
---------
Y
K
G
---
D
I
E
T
-
Q
-------
E
------------
A
----
S
V
-------
S
G
S
F
E
R
I
M
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
----
D
R
-
I
M
-
K
I
R
K
M
I
L
S
D
S
V
----------
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
------
K
A
L
E
G
R
P
M
--
T
V
R
Y
L
D
P
P
L
-
H
E
---
F
V
-------
P
------------
H
T
E
-------
E
E
Q
A
E
L
A
K
N
M
GLT
L
A
E
V
K
A
--
K
V
---
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
--
R
L
--
A
--
V
T
Y
--
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
---
E
V
K
E
E
T
G
I
D
----
I
-
V
P
------
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
----
F
V
K
---
D
V
V
--
V
E
V
A
---
E
Q
V
K
K
E
K
G
----
S
-----
D
---
M
-
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-------
D
-----------
D
A
G
KF
L
-
D
S
--------
Y
-------
Y
K
A
KIYES
D
P
FARL--
D
-----------
Q
----
T
G
V
G
------
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
-
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
--------
10
PsiBlast_PDB
78.95
24%
-54
- C1 -
2R82
2
PPDK_CLOSY
A:
[3-856]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
PK
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
E
A
I
V
Y
R
R
--
M
N
D
IP
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
D
T
G
E
K
G
I
Y
G
---
R
Y
L
I
NA
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
------
T
R
N
G
K
R
T
A
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SL
D
Q
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
EIKINEE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
---------
Y
K
G
---
D
I
E
T
-
Q
E
ASVS
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQTG
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
--------
6
PsiBlast_PDB
78.75
24%
-49
- C1 -
1KBL
6
PPDK_CLOSY
A:
[2-855]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
PK
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
R
A
I
V
Y
R
R
--
M
N
D
IPGDW
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
EYL
I
N
A
---
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
------
T
R
N
G
K
R
T
A
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SLDQ
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
EIKINEE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
---------
Y
K
G
---
D
I
E
T
-
Q
E
A
S
V
S
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQTG
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
--------
12
PsiBlast_PDB
78.58
23%
-47
- C1 -
1VBH
3
PPDK1_MAIZE
A:
[15-861]
--------
E
----
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
----
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
-----
G
CALPA
G
-----
L
----
W
A
E
I
V
D
G
----
L
Q
W
V
E
E
Y
M
G
A
-----------------------------
T
------
L
---
G
D
PQR
P
L
L
L
S
V
R
S
------
G
------
A
A
V
S
M
PG
M
M
D
T
V
L
N
L
G
L
N
D
-----------
E
V
----------
A
A
------
G
L
A
---
A
K
S
G
--------------
E
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
VVMDIP
R
S
L
F
E
E
K
L
E
H
------------------
M
K
E
S
K
G
------
L
K
N
D
T
D
L
T
A
S
D
L
K
E
----
L
V
G
Q
Y
K
E
-
V
Y
L
S
A
-----
K
G
EPFPSD
P
K
-------
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
-
G
T
A
V
N
V
-----
Q
C
M
V
F
G
---
N
M
---
G
---
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
--
E
K
K
L
Y
G
E
F
L
V
N
A
-----------
R
T
P
E
D
L
-------------
D
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
---------
H
Y
K
E
M
----------------
Q
D
I
E
F
T
V
Q
E
N
R
L
---
W
M
L
---
Q
---
C
R
T
G
K
R
---------------------
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
---------------------
L
V
E
------
P
R
--------------------
S
A
I
K
--------
M
V
E
P
G
H
L
D
Q
L
------------------------
L
---
H
--------
P
-
Q
----
F
E
---------
N
-
P
-
S
A
Y
K
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
------
A
V
G
Q
V
V
F
-
T
A
E
D
A
E
A
-
W
-
H
S
Q
G
---
K
A
A
--
I
L
V
R
A
E
T
S
P
E
--
D
V
G
G
M
H
--
A
A
V
G
I
L
T
E
---
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
-------
G
I
R
V
N
DAEK
L
V
T
I
G
G
------------
H
V
L
--
R
E
G
E
W
L
S
L
N
G
S
----------
T
G
E
---
V
---------
I
L
G
-----
K
Q
-
P
-------
L
------------
S
----
P
P
-------
A
-------
L
---------------
S
G
D
L
-----
G
T
F
M
A
W
V
D
D
V
R
K
----
L
--------
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
AS
D
E
R
---
I
K
A
-----
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
-
S
D
F
------
E
G
I
---
F
------
R
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
-
H
E
---
F
L
-------
P
E
G
N
I
E
D
I
V
S
E
L
C
A
E
T
-------
G
A
-------------------
N
----
Q
-
E
-------
D
A
L
A
R
I
E
K
L
S
E
V
-----------
N
P
M
L
G
F
R
G
C
--
R
------
L
G
I
S
Y
P
E
L
T
--
E
M
Q
A
R
A
I
F
E
A
---
A
----
I
A
M
-----
T
-
N
Q
GVQVF
P
E
I
M
V
P
L
V
G
T
P
Q
E
L
G
H
----
Q
V
T
L
I
R
Q
V
A
--
E
K
V
F
---
A
N
-----
V
----
G
-----
K
---
T
I
G
-----
Y
K
V
G
----
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-------
D
DVGKF
I
P
V
Y
L
A
Q
G
I
--
L
-
Q
H
DPFE----
V
-------
L
-------
D
Q
------
R
-----------
G
----
V
G
E
L
------
V
K
F
A
T
E
R
G
R
K
A
--
R
--
P
N
L
------
K
V
--
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
----------
11
PsiBlast_PDB
77.97
23%
-48
- C1 -
1VBG
4
PPDK1_MAIZE
A:
[15-861]
--------
E
----
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
----
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
-----
G
CALPA
G
-----
L
----
W
A
E
I
V
D
G
----
L
Q
W
V
E
E
Y
M
G
A
-----------------------------
T
------
L
---
G
D
PQR
P
L
L
L
S
V
R
S
------
G
------
A
A
V
S
M
PG
M
M
D
T
V
L
N
L
G
L
N
D
-----------
E
V
----------
A
A
------
G
L
A
---
A
K
S
G
--------------
E
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
VVMDIP
R
S
L
F
E
E
K
L
E
H
------------------
M
K
E
S
K
G
------
L
K
N
D
T
D
L
T
A
S
D
L
K
E
----
L
V
G
Q
Y
K
E
-
V
Y
L
S
A
-----
K
G
EPFPSD
P
K
-------
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
-
G
T
A
V
N
V
-----
Q
C
M
V
F
G
---
N
M
---
G
---
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
--
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
--
E
D
V
V
A
G
I
R
T
P
E
D
L
-------------
D
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
---------
H
Y
K
E
M
----------------
Q
D
I
E
F
T
V
Q
E
N
R
L
---
W
M
L
---
Q
---
C
R
T
G
K
R
---------------------
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
---------------------
L
V
E
------
P
R
--------------------
S
A
I
K
--------
M
V
E
P
G
H
L
D
Q
L
------------------------
L
---
H
--------
P
-
Q
----
F
E
---------
N
-
P
-
S
A
Y
K
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
------
A
V
G
Q
V
V
F
-
T
A
E
D
A
E
A
-
W
-
H
S
Q
G
---
K
A
A
--
I
L
V
R
A
E
T
S
P
E
--
D
V
G
G
M
H
--
A
A
V
G
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
-------
G
IRVNDAEK
L
V
T
I
G
G
------------
H
V
L
--
R
E
G
E
W
L
S
L
N
G
S
----------
T
G
E
---
V
---------
I
L
G
-----
K
Q
-
P
-------
L
------------
S
----
P
P
-------
A
-------
L
---------------
S
G
D
L
-----
G
T
F
M
A
W
V
D
D
V
R
K
----
L
--------
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
AS
D
E
R
---
I
K
A
-----
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
-
S
D
F
------
E
G
I
---
F
------
R
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
-
H
E
---
F
L
-------
P
E
G
N
I
E
D
I
V
S
E
L
C
A
E
T
-------
G
A
-------------------
N
----
Q
-
E
-------
D
A
L
A
R
I
E
K
L
S
E
V
-----------
N
P
M
L
G
F
R
G
C
--
R
------
L
G
I
S
Y
P
E
L
T
--
E
M
Q
A
R
A
I
F
E
A
---
A
----
I
A
M
-----
T
-
N
Q
GVQVF
P
E
I
M
V
P
L
V
G
T
P
Q
E
L
G
H
----
Q
V
T
L
I
R
Q
V
A
--
E
K
V
F
---
A
N
-----
V
----
G
-----
K
---
T
I
G
-----
Y
K
V
G
----
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-------
D
DVGKF
I
P
V
Y
L
A
Q
G
I
--
L
-
Q
H
DPFE----
V
-------
L
-------
D
Q
------
R
-----------
G
----
V
G
E
L
------
V
K
F
A
T
E
R
G
R
K
A
--
R
--
P
N
L
------
K
V
--
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
----------
7
PsiBlast_PDB
77.65
24%
-48
- C1 -
1KC7
6
PPDK_CLOSY
A:
[2-855]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
TED
P
L
L
V
S
V
R
S
G
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
PK
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
R
A
I
V
Y
R
R
--
M
N
D
IPGDW
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
EYL
I
N
A
---
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
------
T
R
N
G
K
R
T
A
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SLDQ
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
EIKINEE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
---------
Y
K
G
---
D
I
E
T
-
Q
E
A
S
V
S
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQTG
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
--------
34
HHSearch
77.44
23%
-53
* C1 *
2X0S
-
?
A:
[3-903]
K
K
W
V
Y
Y
F
G
G
----
G
NADG
N
K
N
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
V
N
----
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
E
T
-----
E
-----
T
-----
I
----
P
Q
E
V
A
D
Q
V
R
E
N
V
S
R
V
E
----
K
-----------------------------
E
M
GAKFG
D
PA
N
P
L
-----
L
F
S
V
R
S
G
A
AASM----------
D
T
--
V
L
N
L
G
L
N
K
V
T
V
D
A
W
V
R
R
APRL
E
R
F
V
----------
Y
D
------
S
Y
R
---
R
F
I
T
--------------
M
Y
------------------------------
A
D
IVMQVGR
E
D
F
E
E
A
L
S
R
M
K
E
R
R
-
G
------
T
K
F
D
T
D
L
T
A
S
D
L
K
E
--
L
-
C
D
G
Y
-
L
E
-
L
F
E
L
K
-----
T
G
CSFPQD
P
V
-------
M
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
-
L
L
G
T
A
V
N
V
-----
Q
A
M
V
F
G
---
N
I
NDR
S
---
A
T
---
G
V
A
F
S
R
S
P
S
T
G
--
E
N
F
--
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
-------------
N
H
S
L
S
L
R
W
-----
A
--------
K
---------
A
H
------------
G
-----
V
G
E
---
E
E
R
R
K
R
Y
---
P
S
M
---
E
EAM
P
E
N
Y
R
L
---------------------
L
C
D
V
R
K
R
L
E
N
H
Y
R
------
D
M
Q
-
D
L
E
F
T
V
Q
--
D
G
R
L
W
L
L
Q
------
C
R
------
N
-------------
G
K
R
T
--------
I
H
A
A
V
R
-
I
A
I
D
M
V
N
E
GLIS
R
E
E
A
V
L
R
--------
I
---
D
PYQ
V
D
H
L
M
H
P
N
----
L
E
---------
P
G
A
-
E
K
-
A
N
K
P
I
G
R
G
L
A
A
S
P
G
A
------
A
V
G
Q
V
V
F
-
D
A
E
S
A
K
E
-
W
-
S
G
R
G
---
K
K
V
--
I
M
V
R
L
E
T
S
P
E
--
D
L
A
G
M
D
--
A
A
C
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
-------
D
------------
M
V
I
R
G
KSFKLNG--
S
V
F
--
R
E
G
D
Y
I
---
T
I
----------
D
G
S
K
G
L
I
---------
Y
A
G
---
K
L
K
L
-
R
-------
S
------------
P
DLKG
S
F
Q
T
I
----
L
-------
Q
---------------
W
C
Q
E
-----
M
K
---------
R
----
L
--------
G
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
H
M
F
F
---
E
G
---
S
R
I
N
F
I
R
E
M
I
----
L
A
D
S
A
---------
S
G
R
K
A
A
L
D
K
L
L
P
I
Q
R
A
D
F
V
G
I
L
------
R
A
M
R
G
L
P
V
--
T
I
R
L
L
D
P
P
L
-
H
E
---
F
V
-------
P
------------
H
D
A
-------
A
A
QFELAQKLGMPAE------
K
V
R
N
R
V
N
A
-------
L
--------
H
E
L
-----------
N
P
M
L
G
H
R
G
C
--
R
L
--
G
--
I
T
Y
--
P
E
I
Y
N
M
Q
V
R
A
I
I
E
A
A
I
A
V
S
E
----
E
G
S
S
----
V
-
I
P
------
E
I
M
V
P
L
V
G
K
K
E
E
-
L
S
----
L
I
R
---
E
E
V
--
V
K
T
A
E
A
V
I
T
-----
K
S
G--
K
-----
R
---
V
-
H
-----
Y
T
V
G
----
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
-------
D
-----------
D
A
G
PF
L
-
R
H
--------
Y
G
N
L
GIYA
Q
-------
D
P
------
F
-----------
Q
----
S
I
D
Q
------
E
G
I
G
E
L
V
R
I
A
V
--
T
--
K
G
R
R
V
KPM
L
K
M
--
G
I
C
G
E
H
G
G
-
D
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
D
R
R
A
A
M
K
--
54
Fugue
77.10
22%
-39
- C1 -
1JDE
2
PPDK_CLOSY
A:
[1-873]
A
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
A
G
C
N
L
A
E
M
T
I
L
----
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q
I
T
Q
E
I
----
Q
D
Q
I
F
E
A
----
I
T
W
L
E
----
E
L
N
G
K
K
F
GDTED
P
L
L
V
S
V
R
S
G
A
RASMPG
M
M
D
------
T
---
I
L
-----
N
L
G
L
N
D
------
V
------
A
V
E
G
F
--
A
K
K
T
G
N
P
R
F
A
Y
D
-----------
S
Y
----------
R
R
------
F
I
Q
---
M
Y
S
D
V
V
MEVPK
S
H
F
E
K
I
I
D
A
------------------------------
M
------------------
K
E
E
K
-
G
------
V
H
F
D
T
D
L
T
A
D
D
L
K
E
--
L
A
E
K
F
K
-
A
V
-
Y
K
E
A
M
-----
N
G
EEFPQEP
K
-------
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
-
D
W
G
T
A
V
N
V
-----
Q
T
M
V
F
G
---
N
K
---
G
ET
S
G
T
---
G
V
A
F
T
R
N
P
S
T
G
--
E
K
G
--
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
-------------
T
Q
L
E
N
D
M
-----
P
D
C
Y
K
Q
--
F
M
D
---------
L
A
M
K
L
E
K
H
F
R
D
M
Q
-----------------
D
M
E
---
F
T
I
---
E
---
E
G
K
L
Y
F
---------------------
L
Q
----------
T
R
N
G
K
R
T
A
P
A
-
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
------
E
A
------
V
-------------
V
R
I
E
--------
A
K
S
L
D
Q
L
L
H
--------------------------------------
P
T
F
----
N
P
---------
A
-
A
-
L
K
-
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
------
A
A
G
K
V
Y
F
T
A
-
D
E
A
K
A
-
A
-
H
E
K
G
---
E
R
V
--
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
-------
E
------------
I
K
INEEAK
T
F
E
L
GG
H
T
F
--
A
E
G
D
Y
I
S
L
D
G
S
----------
T
G
K
I
-
E
T
---------
Q
E
A
---
S
V
S
G
-
S
-------
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
---
D
R
I
-
M
K
I
R
K
M
I
L
S
-
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
------
Y
L
D
P
P
L
H
E
--
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
K
N
M
GLT
L
A
------------
E
V
K
-------
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
--
R
L
--
A
VT
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
I
V
P
------
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
----
F
V
K
---
D
V
V
--
V
E
V
A
---
E
Q
-----
V
----
K
-----
K
---
E
-
K
GSD
M
Q
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-------
D
DA---------
G
K
F
--
L
-
D
S
--------
Y
-------
Y
-------
K
A
------
K
IYESDPFARLD
Q
----
T
G
V
G
------
Q
L
V
E
M
A
V
K
K
G
R
--
Q
--
T
R
P
G
L
----
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
-------
8
PsiBlast_PDB
76.38
24%
-44
- C1 -
1GGO
2
PPDK_CLOSY
A:
[2-855]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
TED
P
L
L
V
S
V
R
S
G
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
R
A
I
V
Y
R
R
--
M
N
D
IPGD
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
---
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
------
T
R
NGKRT
A
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SLDQ
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
A
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
EE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
----------------
I
E
T
-
Q
E
A
S
V
S
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQTG
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
-------
5
PsiBlast_PDB
75.61
24%
-47
- C1 -
1DIK
3
PPDK_CLOSY
A:
[3-856]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
TE
D
P
L
L
V
S
V
R
S
A
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
R
A
I
V
Y
R
R
--
M
N
D
IPGD
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
---
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
------
T
R
NGKRT
A
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SLDQ
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
EIKINEE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
----------------
I
E
T
-
Q
E
A
S
V
S
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQT
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
-------
9
PsiBlast_PDB
74.95
24%
-41
- C1 -
2DIK
2
PPDK_CLOSY
A:
[2-855]
-
K
W
V
Y
K
F
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
------------------------------------------------------------------------------------------------
K
------
Q
I
T
Q
-----------
E
I
Q
D
-----------
Q
I
----------
F
E
------
A
I
T
---
W
L
E
E
--------------
L
N
------------------------------
G
------------------
K
K
F
G
-
D
TE
D
P
L
L
V
S
V
R
S
A
A
R
--------
A
S
M
P
G
M
-
M
D
-
T
I
L
N
L
-----
G
------------------
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
PK
S
H
F
E
K
I
I
D
A
---
M
K
---
E
---
E
K
---
G
V
H
F
--
D
T
D
L
T
--
A
D
D
--
L
K
E
L
A
E
K
F
---
K
A
V
Y
K
E
A
M
N
G
E
E
F
PQE
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
--
D
N
P
R
A
I
V
Y
R
R
--
M
N
D
IPGDW
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
---
Q
---
G
E
D
V
V
A
GVRTPQPITQLENDM
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
-------
F
R
D
M
Q
D
M
E
F
T
I
--
E
E
G
K
L
Y
F
L
Q
TANGKR
T
A
------
P
-------------
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
------------------------
R
---
I
--------
E
A
K
SLDQ
L
L
---------
H
-
P
-
T
F
-
N
P
A
A
L
K
A
G
E
V
I
G
S
A
L
PA
S
P
G
A
A
A
G
K
V
Y
F
-
T
-
A
D
-
E
A
-
K
-
A
A
H
E
---
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
--
D
I
E
G
M
H
--
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
EE
A
------------
K
T
------------
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
----------
D
G
S
T
G
K
I
----------------
I
E
T
-
Q
E
A
SVS
G
S
F
------------
E
----
R
I
-------
M
-------
V
---------------
W
A
D
K
-----
F
R
---------
T
----
L
--------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
DR
I
M
K
I
-
R
K
M
I
L
S
D
-----
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
------
R
Y
L
D
P
-
P
L
HE
F
V
P
H
T
E
E
E
Q
-
A
E
---
L
A
-------
K
------------
N
M
G
LT
L
A
E
V
K
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
---
E
----
T
G
I
-----
D
-
I
V
P
-----
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
F
V
K
D
V
V
V
---
E
V
A
--
E
Q
V
K
---
K
E
-----
K
----
G
-----
S
---
D
M
Q
-----
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
DDAGKF
L
D
-----------
S
Y
Y
--
K
-
A
K
--------
I
-------
Y
-------
E
S
------
D
-----------
P
----
F
A
R
L
DQTG
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
--
P
G
L
------
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
-------
16
PsiBlast_PDB
70.44
22%
-50
- C1 -
2X0S
-
?
A:
[207-880]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
L
-
L
G
T
A
V
N
V
-----
Q
A
M
V
F
G
NIN
D
R
---
S
---
A
T
---
G
V
A
F
S
R
S
P
S
T
G
EN
F
F
F
--
G
E
Y
L
V
N
A
Q
G
--
E
D
V
V
A
G
I
R
T
P
Q
Q
I
-----------------------------------
N
---------
H
S
L
S
L
R
W
A
---
K
A
H
G
-----
V
G
E
E
E
R
R
K
R
Y
P
S
M
---
E
E
A
---
M
---
P
E
N
Y
R
L
---------------------
L
C
D
V
R
K
R
L
E
N
H
Y
-------
R
D
M
Q
D
L
E
F
T
V
--
Q
D
G
R
L
W
L
L
Q
------
C
R
------
N
G
K
R
T
I
H
A
A
V
R
I
A
I
D
M
V
N
--------
E
G
L
I
S
R
E
E
A
V
------------------------
L
---
R
--------
I
D
P
----
Y
Q
V
D
H
L
M
H
P
N
L
E
-
P
-
G
A
-
E
K
A
N
K
P
I
G
R
G
L
A
A
S
P
------
G
A
A
V
G
Q
V
-
V
-
F
D
A
E
S
-
A
-
K
E
W
S
GRG
K
K
V
--
I
M
V
R
L
E
T
S
P
E
--
D
L
A
G
M
D
--
A
A
C
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
---
V
S
-------
G
------------
C
G
------------
D
M
V
--
I
R
G
K
S
F
K
L
N
G
S
V
F
R
E
G
D
Y
I
T
I
D
G
S
K
G
L
I
---------
Y
A
G
KLK
L
R
S
P
-
D
-------
L
------------
K
----
G
S
-------
F
-------
Q
---------------
T
I
L
Q
-----
W
C
---------
Q
E
M
KR
L
--------
G
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
H
M
F
F
---
E
G
---
S
R
I
-
N
F
I
R
E
M
I
L
A
D
S
A
S
G
R
-
K
A
A
L
D
K
L
L
P
--
I
Q
R
A
D
F
--------
V
G
I
L
R
-------
A
M
R
G
L
P
V
--
T
I
R
L
L
D
P
P
L
-
H
E
---
F
V
-------
P
------------
H
D
A
-------
A
A
-------------------
Q
----
F
-
E
LAQKLGM
P
--------
A
E
K
V
R
N
R
V
N
ALHEL
N
P
M
L
G
H
R
G
C
--
R
L
G
I
T
--
Y
P
E
I
Y
N
M
Q
V
R
A
I
I
E
A
A
I
A
V
S
E
---
E
----
G
S
S
-----
V
-
I
P
------
E
I
M
V
P
L
V
G
K
K
E
E
---------
L
---
S
L
I
--
R
E
E
V
---
V
K
-----
T
----
A
E
A
V
I
T
K
---
S
-
G
-----
K
R
V
H
Y
T
V
G
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
-------
D
DA---------
G
P
F
--
L
-
R
H
Y
G
N
L
G---
I
-------
Y
-------
A
Q
DPFQSI
D
-----------
Q
----
E
G
I
G
------
E
L
V
R
I
A
V
T
K
G
R
--
R
--
V
K
P
------
M
L
K
M
G
I
C
G
E
H
G
G
D
-
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
D
R
R
A
A
M
K
--
36
HHSearch
66.82
28%
-80
- C1 -
2WQD
1
PT1_STAAU
A:
[152-552]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
D
---
E
S
V
--
V
I
V
G
N
D
L
T
P
S
--
D
T
A
Q
L
N
KE
F
V
Q
G
F
A
T
N
I
G
G
R
T
S
A
S
A
I
M
S
R
S
L
E
I
P
A
I
V
G
T
K
-------
S
------------
I
T
------------
Q
E
V
--
K
Q
G
D
M
I
---
I
V
----------
D
G
L
N
G
D
V
---------
I
V
N
---
P
T
E
D
-
E
-------
L
------------
I
----
A
Y
-------
Q
-------
D
K
R
E
R
Y
F
A
D
K
K
E
L
Q
K
L
R
D
A
D
T
V
T
VD
G
V
---------
H
----
A
--------
E
L
A
A
N
I
G
T
P
N
D
L
P
G
V
I
E
N
G
A
Q
G
I
G
L
Y
R
T
E
F
L
Y
M
---
G
R
----
D
Q
-
M
P
--------------------------
T
E
E
-----
E
Q
F
E
A
Y
K
E
V
L
------
E
A
M
G
G
K
R
V
--
V
V
R
T
L
D
I
G
G
-
D
K
---
E
L
-------
S
------------
Y
L
N
-----------------------------------
L
-------
P
--------
E
E
M
-----------
N
P
F
L
G
Y
R
A
I
--
R
L
--
S
--
L
A
Q
--
Q
D
I
F
R
P
Q
L
R
A
L
L
R
A
S
V
--------
Y
-------
G
-
K
L
------
N
I
M
F
P
M
V
A
T
I
N
E
-
F
R
----
E
A
K
---
A
I
L
--
L
E
E
K
---
E
N
L
K
---
N
E
G
H
D
I
-----
S
---
D
-
D
-----
I
E
L
G
----
I
M
V
E
I
P
A
T
A
A
L
A
D
V
F
A
K
E
V
D
F
F
S
I
G
T
N
D
L
I
Q
Y
T
L
A
A
D
R
-------
M
-----------
S
E
R
--
V
-
S
Y
--------
L
-------
Y
-------
Q
P
------
Y
-----------
N
----
P
S
I
L
------
R
L
V
K
Q
V
I
E
A
S
H
--
K
--
E
G
K
------
W
T
--
G
M
C
G
E
M
A
G
-
D
E
T
A
I
P
L
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
L
K
A
R
R
Q
I
N
G
L
S
K
N
E
M
T
E
L
A
N
R
A
3
PsiBlast_PDB
61.09
26%
-70
- C1 -
2XDF
-
PT1_ECOLI
A:
[149-530]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
A
I
Q
---
D
E
V
--
I
L
V
A
A
D
L
T
P
S
E
T
A
Q
L
N
L
K
--
K
V
L
G
F
I
T
D
A
G
G
R
T
S
H
T
S
I
M
A
R
S
L
E
L
P
A
I
V
G
-
T
-------
G
------------
S
V
------------
T
S
Q
--
V
K
N
D
D
Y
L
I
L
D
A
----------
V
N
N
Q
V
Y
V
NPT
N
E
V
I
D
K
M
R
A
---
V
Q
E
Q
V
A
-------
S
------------
E
----
K
A
-------
E
-------
L
---------------
A
K
L
K
-----
D
L
PAITLD
G
H
-
Q
----
V
--------
E
V
C
A
N
I
G
T
V
R
D
V
E
G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
---
D
R
----
D
A
-
L
P
T
E
----------------
E
E
Q
F
A
A
Y
--------
K
A
V
A
E
A
C
G
-------------
S
Q
A
V
--
I
V
R
T
M
D
I
G
G
-
D
K
ELP
Y
M
-------
N
------------
F
---------------------------------------------
P
--------
K
E
E
-----------
N
P
F
L
G
W
R
A
I
--
R
------
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
---
I
L
R
---
A
----
S
A
F
-----
G
-
K
L
------
R
I
M
F
P
M
I
I
S
V
E
E
-
V
R
A
L
R
-
K
E
I
---
E
I
Y
--
K
Q
E
L
---
R
D
-----
E
----
G
-----
K
AFD
E
-
S
-----
I
E
I
G
----
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
G
-----------
N
D
M
--
I
-
S
H
--------
L
-------
Y
-------
Q
P
------
M
-----------
S
----
P
S
V
L
------
N
L
I
K
Q
V
I
D
A
S
H
--
A
--
E
G
K
------
W
T
--
G
M
C
G
E
L
A
G
D
-
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
K
V
L
A
E
Q
A
4
PsiBlast_PDB
60.49
26%
-69
- C1 -
2L5H
-
PT1_ECOLI
A:
[149-530]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
A
I
Q
---
D
E
V
--
I
L
V
A
A
D
L
T
P
S
E
T
A
Q
L
N
L
K
--
K
V
L
G
F
I
T
D
A
G
G
R
T
S
Q
T
S
I
M
A
R
S
L
E
L
P
A
I
V
G
-
T
-------
G
------------
S
V
------------
T
S
Q
--
V
K
N
D
D
Y
L
I
L
D
A
----------
V
N
N
Q
V
Y
V
NPT
N
E
V
I
D
K
M
R
A
---
V
Q
E
Q
V
A
-------
S
------------
E
----
K
A
-------
E
-------
L
---------------
A
K
L
K
-----
D
L
P
AITLD
G
H
-
Q
----
V
--------
E
V
C
A
N
I
G
T
V
R
D
V
E
G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
---
D
R
----
D
A
-
L
P
T
E
----------------
E
E
Q
F
A
A
Y
--------
K
A
V
A
E
A
C
G
-------------
S
Q
A
V
--
I
V
R
T
M
D
I
G
G
-
D
K
ELP
Y
M
-------
N
------------
F
---------------------------------------------
P
--------
K
E
E
-----------
N
P
F
L
G
W
R
A
I
--
R
------
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
---
I
L
R
---
A
----
S
A
F
-----
G
-
K
L
------
R
I
M
F
P
M
I
I
S
V
E
E
-
V
R
A
L
R
-
K
E
I
---
E
I
Y
--
K
Q
E
L
---
R
D
-----
E
----
G
-----
K
AFD
E
-
S
-----
I
E
I
G
----
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
G
-----------
N
D
M
--
I
-
S
H
--------
L
-------
Y
-------
Q
P
------
M
-----------
S
----
P
S
V
L
------
N
L
I
K
Q
V
I
D
A
S
H
--
A
--
E
G
K
------
W
T
--
G
M
C
G
E
L
A
G
D
-
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
K
V
L
A
E
Q
A
2
PsiBlast_PDB
60.11
26%
-68
- C1 -
2KX9
-
PT1_ECOLI
A:
[149-530]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
A
I
Q
---
D
E
V
--
I
L
V
A
A
D
L
T
P
S
E
T
A
Q
L
N
L
K
--
K
V
L
G
F
I
T
D
A
G
G
R
T
S
H
T
S
I
M
A
R
S
L
E
L
P
A
I
V
G
-
T
-------
G
------------
S
V
------------
T
S
Q
--
V
K
N
D
D
Y
L
I
L
D
A
----------
V
N
N
Q
V
Y
V
NPT
N
E
V
I
D
K
M
R
A
---
V
Q
E
Q
V
A
-------
S
------------
E
----
K
A
-------
E
-------
L
---------------
A
K
L
K
-----
D
L
PAITLD
G
H
-
Q
----
V
--------
E
V
C
A
N
I
G
T
V
R
D
V
E
G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
---
D
R
----
D
A
-
L
P
T
E
----------------
E
E
Q
F
A
A
Y
--------
K
A
V
A
E
A
C
G
-------------
S
Q
A
V
--
I
V
R
T
M
D
I
G
G
-
D
K
ELP
Y
M
-------
N
------------
F
---------------------------------------------
P
--------
K
E
E
-----------
N
P
F
L
G
W
R
A
I
--
R
------
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
---
I
L
R
---
A
----
S
A
F
-----
G
-
K
L
------
R
I
M
F
P
M
I
I
S
V
E
E
-
V
R
A
L
R
-
K
E
I
---
E
I
Y
--
K
Q
E
L
---
R
D
-----
E
----
G
-----
K
AFD
E
-
S
-----
I
E
I
G
----
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
G
-----------
N
D
M
--
I
-
S
H
--------
L
-------
Y
-------
Q
P
------
M
-----------
S
----
P
S
V
L
------
N
L
I
K
Q
V
I
D
A
S
H
--
A
--
E
G
K
------
W
T
--
G
M
C
G
E
L
A
G
D
-
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
K
V
L
A
E
Q
A
1
PsiBlast_PDB
59.97
28%
-66
- C1 -
2WQD
1
PT1_STAAU
A:
[183-544]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
I
G
G
R
T
S
A
S
A
I
M
S
R
S
L
E
I
P
A
I
V
G
T
K
-------
S
------------
I
T
------------
Q
E
V
--
K
Q
G
D
M
I
I
V
-------------
D
G
L
N
G
D
V
---------
I
V
N
---
P
T
E
D
-
E
-------
L
I
A
Y
Q
D
K
R
E
R
Y
F
A
D
----
K
K
-------
E
-------
L
---------------
Q
K
L
R
-----
D
A
---------
D
----
T
V
T
VDG
V
H
A
E
L
A
A
N
I
G
T
P
N
D
L
P
G
V
I
E
N
G
A
Q
G
I
G
L
Y
R
T
E
F
L
Y
M
---
G
R
-----------------
D
Q
M
P
T
E
E
E
Q
F
E
----
A
Y
--------
K
E
V
L
E
A
M
G
-------------
G
K
R
V
--
V
V
R
T
L
D
I
G
G
-
D
K
---
E
L
-------
S
------------
Y
L
N
-----------------------------------
L
-------
P
--------
E
E
M
-----------
N
P
F
L
G
Y
R
A
I
--
R
------
L
S
L
A
Q
Q
D
I
F
R
P
Q
L
R
A
L
--
L
R
A
---
S
----
V
-
Y
-----
G
-
K
L
------
N
I
M
F
P
M
V
A
T
I
N
E
-
F
R
----
E
A
K
---
A
I
L
L
E
E
K
E
N
---
L
K
-----
N
----
E
G
H
D
I
-
S
---
D
-
D
-----
I
E
L
G
----
I
M
V
E
I
P
A
T
A
A
L
A
D
V
F
A
K
E
V
D
F
F
S
I
G
T
N
D
L
I
Q
Y
T
L
A
A
D
R
-------
M
-----------
S
E
R
--
V
-
S
Y
--------
L
-------
Y
-------
Q
P
------
Y
-----------
N
----
P
S
I
L
------
R
L
V
K
Q
V
I
E
A
S
H
--
K
--
E
G
K
------
W
T
--
G
M
C
G
E
M
A
G
D
E
T
A
I
P
-
L
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
L
K
A
R
R
Q
I
N
G
L
S
K
N
E
M
T
E
L
A
N
R
A
37
HHSearch
58.13
28%
-67
- C1 -
2XZ9
2
?
A:
[18-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
K
----
V
--------
M
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
F
L
Y
M
---
D
R
----
N
S
-
L
P
S
--------------------------
E
E
-----
E
Q
F
E
A
Y
K
E
V
V
------
E
K
M
G
G
R
P
V
--
T
I
R
T
L
D
I
G
G
-
D
K
---
E
L
-------
P
------------
Y
L
D
-------
M
-----------------------------------
P
--------
K
E
M
-----------
N
P
F
L
G
Y
R
A
I
--
R
L
--
C
--
L
D
R
--
P
D
I
F
K
T
Q
L
R
A
I
L
R
A
S
A
--------
Y
-------
G
-
N
V
------
Q
I
M
Y
P
M
I
S
S
V
E
E
-
V
R
----
K
A
N
---
S
I
L
--
E
E
V
K
---
A
E
L
D
R
--
E
GVK-
Y
-----
D
---
K
-
E
-----
I
K
V
G
----
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
M
-----------
N
E
H
--
V
-
K
E
--------
Y
-------
Y
-------
Q
P
------
F
-----------
H
----
P
A
I
L
------
R
L
V
K
M
V
I
D
A
A
H
--
K
--
E
G
K
------
F
A
--
A
M
C
G
E
M
A
G
-
D
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
K
A
K
E
I
A
E
K
A
59
Fugue
49.77
21%
-51
- C1 -
1DIK
2
?
?:
[510-874]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
---------
T
Q
E
---
A
S
V
S
-
G
-------
S
------------
F
----
E
R
-------
I
-------
M
---------------
V
W
A
D
-----
K
F
---------
R
----
T
L
-------
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
---
E
A
---
D
R
I
-
M
K
I
R
K
M
I
L
S
-
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
LDPPL
H
E
F
V
P
H
T
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
---
T
L
-------
A
------------
E
V
K
-------
A
K
-------------------
V
----
D
-
E
-------
L
--------
H
E
F
-----------
N
P
M
M
G
H
R
G
----
C
--
R
--
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
---
E
----
V
K
E
E
T
GID
I
-
V
P
------
E
I
M
I
P
L
V
G
E
K
K
E
-
L
K
----
F
V
K
---
D
V
V
--
V
E
V
A
---
E
Q
-----
V
----
K
-----
K
---
E
-
K
GSD
M
Q
Y
H
I
G
----
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-------
D
DA---------
G
K
F
--
L
-
D
S
--------
Y
-------
Y
-------
K
A
------
K
IYESDPFARLD
Q
----
T
G
V
G
------
Q
L
V
E
M
A
V
K
K
G
R
--
Q
--
T
R
P
G
L
----
K
C
--
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
-------